miRTarBase - #MIRT513093


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pre-miRNA Information
pre-miRNA hsa-mir-4260   
Genomic Coordinates chr1: 209623444 - 209623510
Description Homo sapiens miR-4260 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4260
Sequence 11| CUUGGGGCAUGGAGUCCCA |29
Evidence Experimental
Experiments SOLiD
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSM7908770 6 COSMIC
COSN30117883 7 COSMIC
COSN26730871 12 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs372999583 2 dbSNP
rs1367351910 8 dbSNP
rs1266505194 15 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol DYNAP   
Synonyms C18orf26
Description dynactin associated protein
Transcript NM_173629   
Expression
Putative miRNA Targets on DYNAP
3'UTR of DYNAP
(miRNA target sites are highlighted)		 
>DYNAP|NM_173629|3'UTR
   1 TTTGAACAGCCATAGCCATCACTTCAACTGAAACTTCAACCTCTACCACTTCAACTCAGTTTGCAACTATAATAGCTACT
  81 CCTATCACTTCAAGTGGAATCATGGCTGCAGTCACTTTAACAGACTCTATAACCGTTACAACTTCAACAAAATCAAGTCC
 161 TACTTCAACTTAAACTTACTTGACAACTCAAATAATCACCACTTCGACCATCTCTTTGACTGAATCAACAACTACATTCC
 241 CTTCAACTGAATCTGCAACCACTTCCACTTAACCTATAACTACTGTAACTTCTACTTAGCCTACAGTAACAATGCTCATC
 321 ACTCTTTTCCAACAATGTATAATCTCCACCTATTCATCTGAGGACTAAGCTCTGATTTTTCATCTTGCCCAAATTCCTTT
 401 CTAAGGGGTATGGGGAGTCATGCCCTACAAACCATAAATTCTCATCAGATGGGTTTTATTTAACCCTGTATATTGTGACT
 481 TACTTTCTAATCTGACTCTGGCATAACAAGGGAAAAAAATCAAAATGTTTTACCCCAAAATATATTTCCTTGCCATACCT
 561 TGAAATTGTCCTGCAAAGTCTCTTGTGGAGAAACTCCACATTCTGTAGAGAATATCCTTTCCCCTTTGTTTTCCTTCCTT
 641 TCTTTCCAGATCCAGGAGATAATCAACTAAGAGCCAGGCACCCTTTTAGGTCTAATAAGAAACACTTTACAACCTGCTCT
 721 CTCTCTGAAGTCTGCTTTCTGAGAGATTCCTCTGCACAATAAAACTTGATCTCCACAATCCTTTATCTTAACCTGAACAT
 801 TCCTTTCCATGGATCTCAGGTCTTCAGATAAACTAAACCAATTGTCAACCAGAACATGTTTAAATTTACCTATAGCCTGG
 881 AAGCCCCAACTTTGAGTTGTCCTGCCTTTCTGAACCAAGCCAATGTATTTCTTAAATGTATTTGATTGATGTCTCATGTC
 961 TCCCTAAAAATATATAAAACCAAACTGTACCTTAGCCACTTTGGACACATGTTCTCAGGACCTCCTGAGGGCTATGTCAT
1041 GAGCCATGGTCACTCATATTTGGCTCAGAATTAATCTCTTAAAATATTTTACAGAGTTTGACTCTTTTTGTCAACACATC
1121 CGAACCTGCAACTACAAATGCCACCATTACCACTTAAAACTTGATAGAACTAGCATCAGTCATCAAAATAACCTGTTCTA
1201 TATTAAGTTAACTTTTAGTTATCACCAGTAATACTAGCCTACAACTACTCGCCACACTGGCTCTTCCCCAAAATTGAAAT
1281 TGTACAATATGTGAGTCTAATTCTTGCTAACATAACATTATTGCCTACATTAAAAGCTTCTGCAAAGC
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' accCUGAGGUACGGGGUUc 5'
             | ||  | ||||||| 
Target 5' ataGCCTGGAAGCCCCAAc 3'
 872 - 890 148.00 -11.30
2 
miRNA  3' acCCUGAGGUACGGGGUuc 5'
            ||| | |||||||:|  
Target 5' ggGGAGT-CATGCCCTAca 3'
 412 - 429 128.00 -21.70
3 
miRNA  3' accCUGAGGUACGGGGUUc 5'
             |:|||  | |||||| 
Target 5' actGGCTC--TTCCCCAAa 3'
 1256 - 1272 124.00 -14.50
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN1207350 9 COSMIC
COSN30142735 21 COSMIC
COSN24878016 23 COSMIC
COSN30152933 38 COSMIC
COSN30108318 78 COSMIC
COSN31544585 80 COSMIC
COSN27600106 196 COSMIC
COSN20795780 308 COSMIC
COSN29419303 337 COSMIC
COSN6665193 469 COSMIC
COSN505937 526 COSMIC
COSN31967636 634 COSMIC
COSN16308763 1115 COSMIC
COSN5182342 1177 COSMIC
COSN8252546 1232 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs199676564 2 dbSNP
rs754976493 7 dbSNP
rs778648575 8 dbSNP
rs1209771917 10 dbSNP
rs752537435 12 dbSNP
rs758149342 13 dbSNP
rs1373409233 14 dbSNP
rs1192458814 15 dbSNP
rs375979123 18 dbSNP
rs746080132 19 dbSNP
rs1036673191 23 dbSNP
rs780336331 29 dbSNP
rs561029083 41 dbSNP
rs1435681804 48 dbSNP
rs1377702674 70 dbSNP
rs547472348 77 dbSNP
rs528208580 85 dbSNP
rs1419072858 98 dbSNP
rs567351492 98 dbSNP
rs1161172040 103 dbSNP
rs1409360200 111 dbSNP
rs7230876 121 dbSNP
rs988181628 126 dbSNP
rs1471866036 128 dbSNP
rs1257031827 129 dbSNP
rs917959179 130 dbSNP
rs752460267 131 dbSNP
rs1486515470 135 dbSNP
rs774560109 136 dbSNP
rs1045321392 139 dbSNP
rs926841683 159 dbSNP
rs931480422 163 dbSNP
rs571772972 179 dbSNP
rs759508722 180 dbSNP
rs953075674 185 dbSNP
rs1330897701 187 dbSNP
rs1398464470 188 dbSNP
rs768107134 194 dbSNP
rs1009065812 195 dbSNP
rs1416306090 198 dbSNP
rs1018589683 201 dbSNP
rs1453514215 202 dbSNP
rs755578264 206 dbSNP
rs1243296561 212 dbSNP
rs868854403 218 dbSNP
rs1041161715 219 dbSNP
rs1272242762 222 dbSNP
rs1459914850 237 dbSNP
rs1417311156 240 dbSNP
rs371891265 248 dbSNP
rs532635509 262 dbSNP
rs1340466003 266 dbSNP
rs1165903151 269 dbSNP
rs1198453651 275 dbSNP
rs1259916088 304 dbSNP
rs987853816 307 dbSNP
rs1486085099 309 dbSNP
rs915476488 323 dbSNP
rs1257021303 325 dbSNP
rs1456213419 332 dbSNP
rs1219332228 333 dbSNP
rs1333509243 335 dbSNP
rs1273344374 337 dbSNP
rs1234598734 342 dbSNP
rs1315621302 348 dbSNP
rs1294438289 349 dbSNP
rs550873780 354 dbSNP
rs150362771 363 dbSNP
rs980871104 376 dbSNP
rs1439410827 380 dbSNP
rs1393821458 389 dbSNP
rs568862749 393 dbSNP
rs996894400 397 dbSNP
rs753230267 398 dbSNP
rs1028253630 406 dbSNP
rs926794652 408 dbSNP
rs57537350 410 dbSNP
rs753698840 412 dbSNP
rs1170047147 419 dbSNP
rs1374764731 422 dbSNP
rs1428860587 424 dbSNP
rs11875607 429 dbSNP
rs1191665699 432 dbSNP
rs754134860 433 dbSNP
rs1467926159 435 dbSNP
rs1031504828 437 dbSNP
rs955865629 440 dbSNP
rs1479392015 441 dbSNP
rs1250385620 448 dbSNP
rs1421687104 450 dbSNP
rs1308434825 470 dbSNP
rs138201322 471 dbSNP
rs1232556899 472 dbSNP
rs1370828168 477 dbSNP
rs1303463387 482 dbSNP
rs1443142473 482 dbSNP
rs1025437943 484 dbSNP
rs970769608 493 dbSNP
rs534060078 495 dbSNP
rs1038413935 500 dbSNP
rs981150069 502 dbSNP
rs926629885 504 dbSNP
rs1401616152 506 dbSNP
rs1171460156 513 dbSNP
rs899075052 513 dbSNP
rs1453599941 516 dbSNP
rs1395573698 523 dbSNP
rs1195472110 555 dbSNP
rs994766395 560 dbSNP
rs931593449 561 dbSNP
rs984366339 587 dbSNP
rs1320809541 607 dbSNP
rs1050215231 616 dbSNP
rs1327594715 617 dbSNP
rs908720498 620 dbSNP
rs553104091 622 dbSNP
rs868844257 634 dbSNP
rs1040819399 635 dbSNP
rs1347648516 636 dbSNP
rs1276713318 646 dbSNP
rs1237205335 648 dbSNP
rs143933060 659 dbSNP
rs538889554 665 dbSNP
rs1009639345 667 dbSNP
rs1433836694 672 dbSNP
rs932407091 692 dbSNP
rs534835218 700 dbSNP
rs1198299397 703 dbSNP
rs968230797 706 dbSNP
rs1451632195 711 dbSNP
rs1263747507 714 dbSNP
rs535959326 715 dbSNP
rs1488584583 717 dbSNP
rs1186830969 720 dbSNP
rs1485536819 742 dbSNP
rs1281563059 744 dbSNP
rs1202549649 746 dbSNP
rs1349093734 751 dbSNP
rs1260676352 755 dbSNP
rs1239813853 756 dbSNP
rs981006807 758 dbSNP
rs1192588832 771 dbSNP
rs904194156 773 dbSNP
rs1421254484 777 dbSNP
rs926763239 779 dbSNP
rs1314408081 782 dbSNP
rs1000101678 786 dbSNP
rs557290134 788 dbSNP
rs1380322060 792 dbSNP
rs1031514977 800 dbSNP
rs758135294 807 dbSNP
rs891633458 810 dbSNP
rs1177033264 820 dbSNP
rs765932488 836 dbSNP
rs111457791 838 dbSNP
rs1415085026 849 dbSNP
rs1475368773 854 dbSNP
rs1259199223 872 dbSNP
rs1464603704 873 dbSNP
rs908619830 874 dbSNP
rs1261604687 875 dbSNP
rs1160425210 879 dbSNP
rs188577621 884 dbSNP
rs1271426767 887 dbSNP
rs1038744581 891 dbSNP
rs1399936173 891 dbSNP
rs571841818 893 dbSNP
rs1325677372 896 dbSNP
rs1318863490 897 dbSNP
rs919929474 902 dbSNP
rs971247373 906 dbSNP
rs980859136 907 dbSNP
rs1296693726 916 dbSNP
rs560753398 916 dbSNP
rs1034132330 923 dbSNP
rs754417717 926 dbSNP
rs1461530342 935 dbSNP
rs1387750660 943 dbSNP
rs1301537457 947 dbSNP
rs1419521992 956 dbSNP
rs984376506 957 dbSNP
rs908772763 958 dbSNP
rs1474620485 968 dbSNP
rs1311310008 975 dbSNP
rs1230363469 977 dbSNP
rs1261982372 980 dbSNP
rs572869729 988 dbSNP
rs1251694367 996 dbSNP
rs940184737 996 dbSNP
rs780810509 997 dbSNP
rs922777270 1019 dbSNP
rs1468987811 1020 dbSNP
rs889065859 1022 dbSNP
rs1213079754 1023 dbSNP
rs1338487684 1027 dbSNP
rs1261005037 1028 dbSNP
rs748122454 1031 dbSNP
rs373972042 1035 dbSNP
rs1490769663 1036 dbSNP
rs1049483715 1040 dbSNP
rs1040240822 1048 dbSNP
rs1191622895 1058 dbSNP
rs756061562 1081 dbSNP
rs1368636792 1082 dbSNP
rs1302620388 1086 dbSNP
rs777717247 1092 dbSNP
rs568265569 1098 dbSNP
rs1431668006 1100 dbSNP
rs1183997529 1103 dbSNP
rs1351167101 1108 dbSNP
rs1381035297 1115 dbSNP
rs112195632 1118 dbSNP
rs565437962 1122 dbSNP
rs1368081174 1135 dbSNP
rs1458723737 1140 dbSNP
rs1451740008 1146 dbSNP
rs1393760790 1153 dbSNP
rs1014158305 1160 dbSNP
rs1024581440 1164 dbSNP
rs1193601747 1165 dbSNP
rs868532407 1166 dbSNP
rs1248587009 1168 dbSNP
rs1021892590 1170 dbSNP
rs1437393889 1174 dbSNP
rs376086082 1176 dbSNP
rs1206980592 1184 dbSNP
rs1384751671 1185 dbSNP
rs537312132 1194 dbSNP
rs1279497905 1196 dbSNP
rs1310754762 1198 dbSNP
rs903540697 1200 dbSNP
rs1001853546 1201 dbSNP
rs1002708320 1202 dbSNP
rs144845589 1205 dbSNP
rs1238849272 1207 dbSNP
rs952711116 1212 dbSNP
rs1309502207 1213 dbSNP
rs1431979947 1215 dbSNP
rs1005527363 1222 dbSNP
rs1173545678 1229 dbSNP
rs1415608339 1230 dbSNP
rs1283788056 1251 dbSNP
rs550806528 1252 dbSNP
rs1175496600 1255 dbSNP
rs562830994 1258 dbSNP
rs530357336 1261 dbSNP
rs1469720988 1262 dbSNP
rs992731626 1267 dbSNP
rs771231254 1269 dbSNP
rs1484560892 1272 dbSNP
rs961648036 1279 dbSNP
rs1221951847 1281 dbSNP
rs977029671 1292 dbSNP
rs1462576647 1293 dbSNP
rs1313828865 1295 dbSNP
rs1015772168 1307 dbSNP
rs573509544 1328 dbSNP
rs974174069 1334 dbSNP
rs530008381 1337 dbSNP
rs191094707 1339 dbSNP
rs985616804 1341 dbSNP
rs1312579101 1349 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 284254.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM1065668. RNA binding protein: AGO1. Condition:4-thiouridine ...

- Memczak S; Jens M; Elefsinioti A; Torti F; et al., 2013, Nature.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' acccugagguaCGGGGUuc 5'
                     ||| ||  
Target 5' -----------GCCACAcu 3'
 		1 - 8
Article - Memczak S; Jens M; Elefsinioti A; Torti F; et al.
- Nature, 2013
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.
LinkOut: [PMID: 23446348]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HCT116
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in ERX177627. RNA binding protein: AGO2. Condition:p53_D_AGO_CLIP_4_5 ...

- Krell J; Stebbing J; Carissimi C; Dabrowska et al., 2016, Genome research.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' acccugagguaCGGGGUuc 5'
                     ||| ||  
Target 5' -----------GCCACAcu 3'
 		1 - 8
Article - Krell J; Stebbing J; Carissimi C; Dabrowska et al.
- Genome research, 2016
DNA damage activates TP53-regulated surveillance mechanisms that are crucial in suppressing tumorigenesis. TP53 orchestrates these responses directly by transcriptionally modulating genes, including microRNAs (miRNAs), and by regulating miRNA biogenesis through interacting with the DROSHA complex. However, whether the association between miRNAs and AGO2 is regulated following DNA damage is not yet known. Here, we show that, following DNA damage, TP53 interacts with AGO2 to induce or reduce AGO2's association of a subset of miRNAs, including multiple let-7 family members. Furthermore, we show that specific mutations in TP53 decrease rather than increase the association of let-7 family miRNAs, reducing their activity without preventing TP53 from interacting with AGO2. This is consistent with the oncogenic properties of these mutants. Using AGO2 RIP-seq and PAR-CLIP-seq, we show that the DNA damage-induced increase in binding of let-7 family members to the RISC complex is functional. We unambiguously determine the global miRNA-mRNA interaction networks involved in the DNA damage response, validating them through the identification of miRNA-target chimeras formed by endogenous ligation reactions. We find that the target complementary region of the let-7 seed tends to have highly fixed positions and more variable ones. Additionally, we observe that miRNAs, whose cellular abundance or differential association with AGO2 is regulated by TP53, are involved in an intricate network of regulatory feedback and feedforward circuits. TP53-mediated regulation of AGO2-miRNA interaction represents a new mechanism of miRNA regulation in carcinogenesis.
LinkOut: [PMID: 26701625]
CLIP-seq Support 1 for dataset GSM1065668
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / 4-thiouridine, ML_MM_7
Location of target site ENST00000321600.1 | 3UTR | GCCACACUGGCUCUUCCC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
66 hsa-miR-4260 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT074404 TNRC6A trinucleotide repeat containing 6A 2 2
MIRT289774 PER1 period circadian clock 1 2 2
MIRT442576 HOXD9 homeobox D9 2 2
MIRT443878 CNKSR3 CNKSR family member 3 2 2
MIRT449080 XPO6 exportin 6 2 2
MIRT450294 DRAXIN dorsal inhibitory axon guidance protein 2 2
MIRT461785 FXR2 FMR1 autosomal homolog 2 2 2
MIRT463931 WNT10B Wnt family member 10B 2 2
MIRT464860 UBB ubiquitin B 2 8
MIRT467619 SLC7A5 solute carrier family 7 member 5 2 2
MIRT469649 RAC1 Rac family small GTPase 1 2 2
MIRT473421 MDM4 MDM4, p53 regulator 2 2
MIRT473646 MARCKSL1 MARCKS like 1 2 2
MIRT474213 LCOR ligand dependent nuclear receptor corepressor 2 2
MIRT474335 KMT2D lysine methyltransferase 2D 2 2
MIRT474871 KDELR1 KDEL endoplasmic reticulum protein retention receptor 1 2 2
MIRT477440 ELOVL5 ELOVL fatty acid elongase 5 2 2
MIRT478432 DAZAP2 DAZ associated protein 2 2 2
MIRT479851 CCDC6 coiled-coil domain containing 6 2 2
MIRT482507 ACTB actin beta 2 2
MIRT485473 IGF1R insulin like growth factor 1 receptor 2 8
MIRT485670 CCDC64 BICD family like cargo adaptor 1 2 4
MIRT485902 PGPEP1 pyroglutamyl-peptidase I 2 4
MIRT488143 PRRC2B proline rich coiled-coil 2B 2 4
MIRT489455 MSC musculin 2 2
MIRT509568 HIST2H2AB histone cluster 2 H2A family member b 2 4
MIRT513093 DYNAP dynactin associated protein 2 2
MIRT513256 CALM3 calmodulin 3 2 2
MIRT514356 UBBP4 ubiquitin B pseudogene 4 2 6
MIRT522019 PAQR3 progestin and adipoQ receptor family member 3 2 4
MIRT523164 HIST3H3 histone cluster 3 H3 2 2
MIRT523297 HIST1H1B histone cluster 1 H1 family member b 2 2
MIRT524782 BAG5 BCL2 associated athanogene 5 2 2
MIRT530921 SCIN scinderin 2 2
MIRT533302 USP44 ubiquitin specific peptidase 44 2 2
MIRT552782 YIPF4 Yip1 domain family member 4 2 4
MIRT553981 SRPR SRP receptor alpha subunit 2 2
MIRT563126 ZNF215 zinc finger protein 215 2 2
MIRT569025 IL21R interleukin 21 receptor 2 2
MIRT573413 RPL18A ribosomal protein L18a 2 2
MIRT574877 Dnajc6 DnaJ heat shock protein family (Hsp40) member C6 2 3
MIRT607538 GLI2 GLI family zinc finger 2 2 2
MIRT607682 MAPK10 mitogen-activated protein kinase 10 2 3
MIRT623791 GK5 glycerol kinase 5 (putative) 2 2
MIRT628834 FAM151B family with sequence similarity 151 member B 2 2
MIRT635547 LEPREL1 prolyl 3-hydroxylase 2 2 2
MIRT635698 NMNAT2 nicotinamide nucleotide adenylyltransferase 2 2 2
MIRT635906 ARPC1B actin related protein 2/3 complex subunit 1B 2 2
MIRT649985 MSI1 musashi RNA binding protein 1 2 2
MIRT654900 POMGNT1 protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) 2 2
MIRT655116 PHF7 PHD finger protein 7 2 2
MIRT658958 DNAJC6 DnaJ heat shock protein family (Hsp40) member C6 2 3
MIRT659665 CDC42EP4 CDC42 effector protein 4 2 2
MIRT668946 CNBP CCHC-type zinc finger nucleic acid binding protein 2 2
MIRT691164 APOL6 apolipoprotein L6 2 2
MIRT692696 MEAF6 MYST/Esa1 associated factor 6 2 2
MIRT693245 HBS1L HBS1 like translational GTPase 2 2
MIRT695203 SCAMP3 secretory carrier membrane protein 3 2 2
MIRT701957 MINK1 misshapen like kinase 1 2 2
MIRT706802 APOL4 apolipoprotein L4 2 2
MIRT716899 CACNB2 calcium voltage-gated channel auxiliary subunit beta 2 2 2
MIRT717632 HLX H2.0 like homeobox 2 2
MIRT719052 ZNF281 zinc finger protein 281 2 2
MIRT722973 GDE1 glycerophosphodiester phosphodiesterase 1 2 2
MIRT723643 RPTN repetin 2 2
MIRT734708 NR3C2 nuclear receptor subfamily 3 group C member 2 4 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4260 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-4260 Neoadjuvant chemotherapy resistant tissue (breast cancer)
hsa-miR-4260 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)
hsa-miR-4260 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-miR-4260 Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide resistant cell line (Bads-200)

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