miRTarBase - #MIRT513246


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pre-miRNA Information
pre-miRNA hsa-mir-3663   
Genomic Coordinates chr10: 117167678 - 117167774
Description Homo sapiens miR-3663 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-3663-5p
Sequence 21| GCUGGUCUGCGUGGUGCUCGG |41
Evidence Experimental
Experiments Northern
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs111525499 10 dbSNP
rs1186183324 11 dbSNP
rs1166397684 12 dbSNP
rs1391472885 17 dbSNP
rs1461514502 20 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol FBXO17   
Synonyms FBG4, FBX26, FBXO26, Fbx17
Description F-box protein 17
Transcript NM_024907   
Other Transcripts NM_148169   
Expression
Putative miRNA Targets on FBXO17
3'UTR of FBXO17
(miRNA target sites are highlighted)		 
>FBXO17|NM_024907|3'UTR
   1 CGACTGGACTACTGCCTGACGTTGTCAGTCAAGACCAGCCTTGCAGCCAGGTGCAGTGGCTCACACCTGTGGAATCCCAG
  81 CACTTCAGGAGGCCGAGGTGGGAGGATCACTGGAGCTCGGGAGTTCAAGACCAGCCTGGGCAACATAGTGAAACCGTCTC
 161 CACAAATAATTTTTAAAAAATTAGCCAGGCATGGTGGTGCCGCCTGTAGTCCCAGCTACTCAGGAGGCTTGGGTGGGAGG
 241 ATTGCCTGAGACCAGGAGGTTGAGGCTGCAGTGAGCCGTGATTTCACCACCACTCCAGCCTGGGTGAGAAAGCAAGACCC
 321 TATATCAATGAAAAAAAAAAAAAAAAAGACCAGCTTTGCAGCCAGAAGCCAGAGGATACCCAGGGACAGTAGGGCTCCCA
 401 GGTGGCTGGTTCTCAGCACACCTTCCATGAATCTGCTTGCTGCTGCTTCAGTGTGGTGGCCATCATGCTGTGTGACAAAC
 481 CAGGCTGTTCACAGCTTCCTCAGCCCCCCAGAAGGGGAGTGTCAGGAAGAGACATTTAGTTCATTTGCCTGCAAATTTTC
 561 TTCTCCTGCAAGGATCTCGGTGGACTCAGTCACAAAACAAAGGCTAAACCAGGATTTATAAGAGAGGGCTTATAAATCCC
 641 TCTGCCGACGCAGGGAGCAGAGACTTGCCGGCATGTTTTGGGGGTAATGATCGTGGGCAGGGAGCAGAGGTCCGCTGAGG
 721 CAGTCTGTCCTTGAGACTAACAAAGTCATCTGCTGTTTGGGGAAATCTCTGGTGTTGGGAACAGGCCCCCAAATCTGGCC
 801 ATAAACTGGCCCCAAAACTGGCCATAAACAAAATATCTGCAGCACTGTGACATGTTTGTGATGGCCATGACCCCCACCCT
 881 GAAGGTTGTGGGTTTACTGGAACGAGGGCGAGGAACACCTGGCCCACCCAGGGCGGAAAACCGCTTAAAGGGGTTCCTGA
 961 ACCACAAACCATAGCATAAGTGATCTGTGCCTTAACGACATGTTCCTGCTGCAGATAACTAGCCAGACCCATCCCTTTAT
1041 TTCAGCCCATCCCTTTATTTCCTGTAAGAAATGTTTTTAGTTAATCTATAATCTATAGAAATAATGCTTATCACTGGCTT
1121 GCTGTCAATAAATATGTGGGTAAATCTCTGTTCAAGGCTCTCAGCTCTGAAGGCCGTGAGACCCCTGATTTCCCACTCCA
1201 CACCCTAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' ggCUCGUGGUGCG-UCUGGUCg 5'
            ||| |:::| : ||||||| 
Target 5' ggGAGGATTGCCTGAGACCAGg 3'
 235 - 256 155.00 -16.30
2 
miRNA  3' ggCUCGUGGUGCGUCUGGUCg 5'
            |||: :||   ||||||| 
Target 5' ggGAGT-TCA---AGACCAGc 3'
 119 - 135 147.00 -16.60
3 
miRNA  3' ggcucGUGGUGCG-UCUGGUCg 5'
               :::||  | ||||||| 
Target 5' gacgtTGTCAGTCAAGACCAGc 3'
 18 - 39 144.00 -17.30
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30521298 7 COSMIC
COSN26600634 26 COSMIC
COSN30177842 67 COSMIC
COSN2532023 71 COSMIC
COSN30485021 90 COSMIC
COSN30185649 92 COSMIC
COSN31546249 108 COSMIC
COSN31525728 185 COSMIC
COSN20284028 201 COSMIC
COSN23781039 211 COSMIC
COSN9850118 277 COSMIC
COSN16647782 714 COSMIC
COSN26792119 903 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1408882408 1 dbSNP
rs373093662 2 dbSNP
rs763670613 4 dbSNP
rs762611266 6 dbSNP
rs1370038187 8 dbSNP
rs200982174 20 dbSNP
rs201740315 21 dbSNP
rs1049785390 27 dbSNP
rs1375800476 29 dbSNP
rs759489583 34 dbSNP
rs931888512 36 dbSNP
rs776379929 39 dbSNP
rs770930701 47 dbSNP
rs555856992 48 dbSNP
rs377179130 49 dbSNP
rs772408467 51 dbSNP
rs1040170475 56 dbSNP
rs761996057 58 dbSNP
rs1359391628 66 dbSNP
rs1213698308 77 dbSNP
rs180731503 78 dbSNP
rs1301350667 81 dbSNP
rs774522253 91 dbSNP
rs944515239 94 dbSNP
rs545309482 95 dbSNP
rs1465588088 100 dbSNP
rs1365650082 109 dbSNP
rs1012036615 112 dbSNP
rs398101208 112 dbSNP
rs77963530 112 dbSNP
rs1192052557 115 dbSNP
rs75826607 116 dbSNP
rs879897920 118 dbSNP
rs539729622 119 dbSNP
rs1457743729 123 dbSNP
rs1320039404 134 dbSNP
rs1343276034 136 dbSNP
rs142493335 142 dbSNP
rs1391915227 146 dbSNP
rs946496781 155 dbSNP
rs1221181314 156 dbSNP
rs1282140142 157 dbSNP
rs914885617 175 dbSNP
rs1230838051 178 dbSNP
rs1282575413 181 dbSNP
rs78169360 183 dbSNP
rs1041081893 187 dbSNP
rs1248703869 188 dbSNP
rs943998616 197 dbSNP
rs990542034 201 dbSNP
rs1252717719 202 dbSNP
rs959874533 203 dbSNP
rs1160241516 204 dbSNP
rs1405441857 207 dbSNP
rs1399929010 215 dbSNP
rs1164980754 232 dbSNP
rs1367024663 242 dbSNP
rs1402760513 249 dbSNP
rs1264572337 260 dbSNP
rs1301980455 275 dbSNP
rs1035239272 278 dbSNP
rs370849896 290 dbSNP
rs989365152 294 dbSNP
rs1350359192 303 dbSNP
rs1203413520 307 dbSNP
rs1484267039 308 dbSNP
rs377658792 318 dbSNP
rs1233239784 320 dbSNP
rs1310965365 321 dbSNP
rs1303432066 322 dbSNP
rs1219913617 323 dbSNP
rs1350062818 326 dbSNP
rs1306450033 327 dbSNP
rs1209940070 330 dbSNP
rs1275370314 331 dbSNP
rs1484081650 339 dbSNP
rs928852050 347 dbSNP
rs1231130479 348 dbSNP
rs1370562346 348 dbSNP
rs1491083581 348 dbSNP
rs35798218 348 dbSNP
rs547335471 348 dbSNP
rs752156890 348 dbSNP
rs868733729 348 dbSNP
rs151056469 349 dbSNP
rs139029236 350 dbSNP
rs1335662417 365 dbSNP
rs1449492251 375 dbSNP
rs981760376 382 dbSNP
rs1381057550 383 dbSNP
rs1245436731 397 dbSNP
rs1015777665 403 dbSNP
rs1375878868 409 dbSNP
rs756688719 421 dbSNP
rs1194131633 423 dbSNP
rs1177555374 432 dbSNP
rs970326558 451 dbSNP
rs1023347875 453 dbSNP
rs1244680512 457 dbSNP
rs561359285 462 dbSNP
rs575 465 dbSNP
rs1252910351 470 dbSNP
rs1476216970 474 dbSNP
rs1200256793 481 dbSNP
rs1165648613 482 dbSNP
rs767930105 484 dbSNP
rs763124405 486 dbSNP
rs1395218460 493 dbSNP
rs1482537097 495 dbSNP
rs952552341 504 dbSNP
rs1026848297 509 dbSNP
rs1452404233 510 dbSNP
rs1298867457 511 dbSNP
rs35871044 518 dbSNP
rs1328396895 533 dbSNP
rs1225601008 542 dbSNP
rs1269656670 544 dbSNP
rs1210869280 554 dbSNP
rs1328642382 556 dbSNP
rs1459774869 560 dbSNP
rs1286669354 565 dbSNP
rs528197721 579 dbSNP
rs564108203 582 dbSNP
rs1448358929 602 dbSNP
rs1190597941 604 dbSNP
rs897091477 609 dbSNP
rs368836332 610 dbSNP
rs1028723334 617 dbSNP
rs1427791695 619 dbSNP
rs370582189 628 dbSNP
rs1469779423 636 dbSNP
rs1321634937 638 dbSNP
rs996887508 641 dbSNP
rs1380685304 642 dbSNP
rs901195445 646 dbSNP
rs144577607 647 dbSNP
rs149327347 649 dbSNP
rs1281509400 650 dbSNP
rs1469852337 652 dbSNP
rs902323116 654 dbSNP
rs947515416 662 dbSNP
rs138779145 665 dbSNP
rs1156319367 669 dbSNP
rs1473336965 670 dbSNP
rs564402588 675 dbSNP
rs1364044796 679 dbSNP
rs893195752 680 dbSNP
rs1266237665 681 dbSNP
rs1480386636 683 dbSNP
rs1160563745 689 dbSNP
rs1187237985 690 dbSNP
rs770123264 692 dbSNP
rs1158160972 693 dbSNP
rs762180927 698 dbSNP
rs990986766 700 dbSNP
rs542154378 713 dbSNP
rs928892371 714 dbSNP
rs1404189147 718 dbSNP
rs1307658384 719 dbSNP
rs1321007454 724 dbSNP
rs79436048 734 dbSNP
rs1236589161 735 dbSNP
rs1259970733 737 dbSNP
rs927615598 747 dbSNP
rs982326669 748 dbSNP
rs948971745 751 dbSNP
rs1210694511 754 dbSNP
rs961655943 758 dbSNP
rs916272507 761 dbSNP
rs990434260 762 dbSNP
rs1265124101 763 dbSNP
rs1016175475 772 dbSNP
rs984328581 777 dbSNP
rs1253311970 778 dbSNP
rs952895030 780 dbSNP
rs1028379414 781 dbSNP
rs1243766950 784 dbSNP
rs7256293 786 dbSNP
rs1181496624 787 dbSNP
rs372696311 792 dbSNP
rs901143253 802 dbSNP
rs1314762563 809 dbSNP
rs919648738 822 dbSNP
rs1364386763 823 dbSNP
rs1161911015 830 dbSNP
rs1364996724 834 dbSNP
rs7257007 835 dbSNP
rs1300023835 837 dbSNP
rs1398508577 845 dbSNP
rs1008762615 847 dbSNP
rs902480385 849 dbSNP
rs1385192597 854 dbSNP
rs1306011555 857 dbSNP
rs1383270381 858 dbSNP
rs1162335346 864 dbSNP
rs1456701747 865 dbSNP
rs1247627080 867 dbSNP
rs1042597590 875 dbSNP
rs1010709258 877 dbSNP
rs1312500081 886 dbSNP
rs1358041560 887 dbSNP
rs573409438 892 dbSNP
rs1252594849 893 dbSNP
rs1479941382 899 dbSNP
rs1195786587 903 dbSNP
rs185507168 904 dbSNP
rs1446854664 909 dbSNP
rs539997056 910 dbSNP
rs1384821319 911 dbSNP
rs1054842769 912 dbSNP
rs1028354236 924 dbSNP
rs569356205 927 dbSNP
rs771381475 934 dbSNP
rs1011960538 935 dbSNP
rs1330591883 939 dbSNP
rs1296296038 942 dbSNP
rs1164614278 943 dbSNP
rs1381544901 955 dbSNP
rs1214864247 956 dbSNP
rs1297080497 964 dbSNP
rs746555827 972 dbSNP
rs1305263181 983 dbSNP
rs777191367 984 dbSNP
rs1449339367 986 dbSNP
rs1264331533 987 dbSNP
rs113378667 992 dbSNP
rs927605920 998 dbSNP
rs757906795 1000 dbSNP
rs1246759357 1005 dbSNP
rs557594898 1011 dbSNP
rs1202138040 1014 dbSNP
rs1190558742 1026 dbSNP
rs142589191 1027 dbSNP
rs1188523552 1028 dbSNP
rs1266921072 1030 dbSNP
rs1208351822 1033 dbSNP
rs747808810 1034 dbSNP
rs567693031 1051 dbSNP
rs1266927347 1062 dbSNP
rs908822833 1063 dbSNP
rs1429878030 1071 dbSNP
rs1246473033 1078 dbSNP
rs1173981148 1088 dbSNP
rs762320669 1089 dbSNP
rs546220786 1091 dbSNP
rs1290298653 1095 dbSNP
rs1295373446 1100 dbSNP
rs138300854 1103 dbSNP
rs1326563748 1104 dbSNP
rs112677105 1105 dbSNP
rs1322469202 1110 dbSNP
rs1134180 1112 dbSNP
rs1283415051 1113 dbSNP
rs1326277156 1122 dbSNP
rs1222288335 1128 dbSNP
rs1384650021 1128 dbSNP
rs1392447881 1131 dbSNP
rs1262850728 1146 dbSNP
rs753626982 1160 dbSNP
rs551987452 1161 dbSNP
rs975435647 1162 dbSNP
rs10418682 1164 dbSNP
rs1171102942 1171 dbSNP
rs930937535 1171 dbSNP
rs919696637 1172 dbSNP
rs1424157480 1175 dbSNP
rs181742085 1176 dbSNP
rs1343044126 1177 dbSNP
rs1377072530 1178 dbSNP
rs1418785566 1179 dbSNP
rs1303217479 1186 dbSNP
rs1346868609 1202 dbSNP
rs1419650120 1207 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 115290.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM1065668. RNA binding protein: AGO1. Condition:4-thiouridine ...

- Memczak S; Jens M; Elefsinioti A; Torti F; et al., 2013, Nature.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' ggcucguggugcgUCUGGUCg 5'
                       ||||||| 
Target 5' -----------ugAGACCAGg 3'
 		1 - 10
Article - Memczak S; Jens M; Elefsinioti A; Torti F; et al.
- Nature, 2013
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.
LinkOut: [PMID: 23446348]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084081. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep2_SantaCruzAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM4903833
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_a
Location of target site NM_024907 | 3UTR | AAGACCAGCUUUGCA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM4903835
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_c
Location of target site NM_148169 | 3UTR | AAGACCAGCUUUGCA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM4903838
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_c
Location of target site NM_024907 | 3UTR | AAGACCAGCUUUGCA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM1084081
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep2_SantaCruzAb
Location of target site ENST00000292852.4 | 3UTR | CAAUGAAAAAAAAAAAAAAAAAGAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM1065668
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / 4-thiouridine, ML_MM_7
Location of target site ENST00000292852.4 | 3UTR | UGAGACCAGGAGGUUGA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
203 hsa-miR-3663-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT222528 CRCP CGRP receptor component 2 2
MIRT442432 CACNG8 calcium voltage-gated channel auxiliary subunit gamma 8 2 6
MIRT450423 BCL2L14 BCL2 like 14 2 2
MIRT456341 RCSD1 RCSD domain containing 1 2 2
MIRT479763 CCND1 cyclin D1 2 2
MIRT487162 IFRD1 interferon related developmental regulator 1 2 8
MIRT495471 ALDOA aldolase, fructose-bisphosphate A 2 2
MIRT497193 DUSP18 dual specificity phosphatase 18 2 2
MIRT499717 PAGR1 PAXIP1 associated glutamate rich protein 1 2 10
MIRT502681 CSNK1G3 casein kinase 1 gamma 3 2 8
MIRT503641 POLR2F RNA polymerase II subunit F 2 4
MIRT510824 SBNO1 strawberry notch homolog 1 2 4
MIRT512347 ZNF665 zinc finger protein 665 2 4
MIRT512528 ATCAY ATCAY, caytaxin 2 4
MIRT513246 FBXO17 F-box protein 17 2 4
MIRT513502 NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit 2 6
MIRT516033 PTAFR platelet activating factor receptor 2 2
MIRT517669 TRIM72 tripartite motif containing 72 2 2
MIRT517691 FAM175A abraxas 1, BRCA1 A complex subunit 2 2
MIRT519524 ZNF8 zinc finger protein 8 2 2
MIRT520953 SRSF10 serine and arginine rich splicing factor 10 2 2
MIRT522074 ORAI2 ORAI calcium release-activated calcium modulator 2 2 4
MIRT525333 CNGB1 cyclic nucleotide gated channel beta 1 2 2
MIRT526504 POU5F1B POU class 5 homeobox 1B 2 2
MIRT527847 RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis) 2 2
MIRT529211 CYP20A1 cytochrome P450 family 20 subfamily A member 1 2 2
MIRT530071 VN1R1 vomeronasal 1 receptor 1 2 2
MIRT530639 PPIC peptidylprolyl isomerase C 2 4
MIRT530679 CHRNB1 cholinergic receptor nicotinic beta 1 subunit 2 4
MIRT532177 SEC14L5 SEC14 like lipid binding 5 2 2
MIRT532432 DHX33 DEAH-box helicase 33 2 2
MIRT532832 ZNF704 zinc finger protein 704 2 2
MIRT534236 SLC25A16 solute carrier family 25 member 16 2 4
MIRT535115 PLXNA2 plexin A2 2 2
MIRT535563 OMD osteomodulin 2 2
MIRT536487 KIAA1468 KIAA1468 2 2
MIRT538371 CRISPLD2 cysteine rich secretory protein LCCL domain containing 2 2 2
MIRT539931 NUCB1 nucleobindin 1 2 4
MIRT562305 GINM1 glycoprotein integral membrane 1 2 2
MIRT563280 BBS10 Bardet-Biedl syndrome 10 2 2
MIRT618205 C22orf39 chromosome 22 open reading frame 39 2 2
MIRT620113 HARBI1 harbinger transposase derived 1 2 2
MIRT621189 FAM153B family with sequence similarity 153 member B 2 2
MIRT623755 GRID1 glutamate ionotropic receptor delta type subunit 1 2 2
MIRT624059 EIF4E eukaryotic translation initiation factor 4E 2 2
MIRT625016 TMIGD2 transmembrane and immunoglobulin domain containing 2 2 2
MIRT626073 CWF19L1 CWF19 like 1, cell cycle control (S. pombe) 2 2
MIRT627875 PAN2 PAN2 poly(A) specific ribonuclease subunit 2 2
MIRT629306 PTPLAD2 3-hydroxyacyl-CoA dehydratase 4 1 1
MIRT630446 IDE insulin degrading enzyme 2 2
MIRT631000 ZNF573 zinc finger protein 573 2 2
MIRT631093 UQCRB ubiquinol-cytochrome c reductase binding protein 2 2
MIRT631282 SGSM1 small G protein signaling modulator 1 2 2
MIRT631530 MYO6 myosin VI 2 2
MIRT631642 WDR91 WD repeat domain 91 2 4
MIRT631825 TMEM154 transmembrane protein 154 2 2
MIRT632778 LZIC leucine zipper and CTNNBIP1 domain containing 2 2
MIRT633278 FGFR1OP2 FGFR1 oncogene partner 2 2 2
MIRT633658 SLC28A1 solute carrier family 28 member 1 2 2
MIRT634071 PLIN3 perilipin 3 2 2
MIRT634159 YME1L1 YME1 like 1 ATPase 2 2
MIRT634227 TMEM132B transmembrane protein 132B 2 2
MIRT636401 MYO5A myosin VA 2 2
MIRT638678 GCLM glutamate-cysteine ligase modifier subunit 2 2
MIRT640231 TOMM40 translocase of outer mitochondrial membrane 40 2 2
MIRT640304 PRR13 proline rich 13 2 2
MIRT641125 NPHP3 nephrocystin 3 2 2
MIRT643422 ERVMER34-1 endogenous retrovirus group MER34 member 1, envelope 2 2
MIRT643700 KIAA0586 KIAA0586 2 2
MIRT644314 NFKBID NFKB inhibitor delta 2 2
MIRT644345 MPV17L MPV17 mitochondrial inner membrane protein like 2 2
MIRT645736 POLR3A RNA polymerase III subunit A 2 2
MIRT648058 TRMT10C tRNA methyltransferase 10C, mitochondrial RNase P subunit 2 2
MIRT649462 UBA5 ubiquitin like modifier activating enzyme 5 2 2
MIRT650009 KLB klotho beta 2 2
MIRT650567 YIPF4 Yip1 domain family member 4 2 2
MIRT652639 TIMM10 translocase of inner mitochondrial membrane 10 2 2
MIRT653887 SGK3 serum/glucocorticoid regulated kinase family member 3 2 2
MIRT655369 PCBD2 pterin-4 alpha-carbinolamine dehydratase 2 2 2
MIRT659116 DENND6A DENN domain containing 6A 2 2
MIRT659520 CHST3 carbohydrate sulfotransferase 3 2 2
MIRT659946 C8orf44-SGK3 C8orf44-SGK3 readthrough 2 2
MIRT661384 RHCG Rh family C glycoprotein 2 2
MIRT662910 MED18 mediator complex subunit 18 2 2
MIRT663107 NPR1 natriuretic peptide receptor 1 2 2
MIRT663759 ZNF285 zinc finger protein 285 2 2
MIRT664554 MKI67IP nucleolar protein interacting with the FHA domain of MKI67 1 1
MIRT664611 LIMD1 LIM domains containing 1 2 2
MIRT666193 SMCR8 Smith-Magenis syndrome chromosome region, candidate 8 2 2
MIRT666794 PSMD1 proteasome 26S subunit, non-ATPase 1 2 2
MIRT668752 DDX19B DEAD-box helicase 19B 2 2
MIRT669601 AGO3 argonaute 3, RISC catalytic component 2 2
MIRT669704 AAK1 AP2 associated kinase 1 2 2
MIRT669812 STOML1 stomatin like 1 2 2
MIRT669927 LRPAP1 LDL receptor related protein associated protein 1 2 2
MIRT669951 FBXL2 F-box and leucine rich repeat protein 2 2 2
MIRT670005 GPR156 G protein-coupled receptor 156 2 4
MIRT670051 RPP14 ribonuclease P/MRP subunit p14 2 2
MIRT670301 RBBP4 RB binding protein 4, chromatin remodeling factor 2 2
MIRT670390 EMP2 epithelial membrane protein 2 2 2
MIRT670457 RSBN1L round spermatid basic protein 1 like 2 2
MIRT670486 DCUN1D2 defective in cullin neddylation 1 domain containing 2 2 2
MIRT670568 GLTP glycolipid transfer protein 2 2
MIRT671061 KIF1B kinesin family member 1B 2 2
MIRT671085 ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 2 2
MIRT671306 RABGAP1L RAB GTPase activating protein 1 like 2 2
MIRT671807 WISP3 WNT1 inducible signaling pathway protein 3 2 2
MIRT671956 SPPL3 signal peptide peptidase like 3 2 2
MIRT671993 OSTF1 osteoclast stimulating factor 1 2 2
MIRT672092 WDR5B WD repeat domain 5B 2 2
MIRT672273 SHE Src homology 2 domain containing E 2 2
MIRT672447 TTPAL alpha tocopherol transfer protein like 2 2
MIRT672451 SLC4A1 solute carrier family 4 member 1 (Diego blood group) 2 2
MIRT673652 CYCS cytochrome c, somatic 2 2
MIRT674003 KCNN3 potassium calcium-activated channel subfamily N member 3 2 2
MIRT674054 ATXN3 ataxin 3 2 2
MIRT674248 NUP62 nucleoporin 62 2 2
MIRT674437 MIOX myo-inositol oxygenase 2 4
MIRT674476 BCL2L15 BCL2 like 15 2 2
MIRT675472 NUBPL nucleotide binding protein like 2 2
MIRT675667 IVD isovaleryl-CoA dehydrogenase 2 2
MIRT675978 FAM126B family with sequence similarity 126 member B 2 2
MIRT676064 HSPE1-MOB4 HSPE1-MOB4 readthrough 2 2
MIRT676120 SCIMP SLP adaptor and CSK interacting membrane protein 2 2
MIRT676241 PARP2 poly(ADP-ribose) polymerase 2 2 2
MIRT676257 PBOV1 prostate and breast cancer overexpressed 1 2 2
MIRT676388 SEC24D SEC24 homolog D, COPII coat complex component 2 2
MIRT676744 SGTB small glutamine rich tetratricopeptide repeat containing beta 2 2
MIRT676880 ENSA endosulfine alpha 2 2
MIRT676905 PHLDA3 pleckstrin homology like domain family A member 3 2 2
MIRT676922 KLHDC8A kelch domain containing 8A 2 2
MIRT676968 RNF19B ring finger protein 19B 2 2
MIRT677048 ZNF34 zinc finger protein 34 2 2
MIRT677114 SS18L1 SS18L1, nBAF chromatin remodeling complex subunit 2 2
MIRT677324 PIGO phosphatidylinositol glycan anchor biosynthesis class O 2 2
MIRT677466 PDLIM3 PDZ and LIM domain 3 2 2
MIRT677584 TRIM65 tripartite motif containing 65 2 2
MIRT677646 HAUS2 HAUS augmin like complex subunit 2 2 2
MIRT677736 MOB4 MOB family member 4, phocein 2 2
MIRT677813 MRPS10 mitochondrial ribosomal protein S10 2 2
MIRT677830 TSPYL1 TSPY like 1 2 2
MIRT678083 EIF2A eukaryotic translation initiation factor 2A 2 2
MIRT678158 ZNF724P zinc finger protein 724 2 2
MIRT678256 FXN frataxin 2 2
MIRT678326 FBLIM1 filamin binding LIM protein 1 2 2
MIRT678419 ANKRD36 ankyrin repeat domain 36 2 2
MIRT678588 C15orf40 chromosome 15 open reading frame 40 2 2
MIRT678598 ARPC2 actin related protein 2/3 complex subunit 2 2 2
MIRT678831 PDE6A phosphodiesterase 6A 2 2
MIRT678945 MYADM myeloid associated differentiation marker 2 2
MIRT679046 CHCHD5 coiled-coil-helix-coiled-coil-helix domain containing 5 2 2
MIRT679201 FLVCR1 feline leukemia virus subgroup C cellular receptor 1 2 2
MIRT679205 FAM9B family with sequence similarity 9 member B 2 2
MIRT679223 MAN2A2 mannosidase alpha class 2A member 2 2 2
MIRT679270 POLM DNA polymerase mu 2 2
MIRT679288 DEGS1 delta 4-desaturase, sphingolipid 1 2 2
MIRT679316 NPHP1 nephrocystin 1 2 2
MIRT679485 CYTIP cytohesin 1 interacting protein 2 2
MIRT679551 LIPG lipase G, endothelial type 2 2
MIRT679625 TTC31 tetratricopeptide repeat domain 31 2 2
MIRT679649 MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 2 2
MIRT679761 TLR6 toll like receptor 6 2 2
MIRT680124 ZNF576 zinc finger protein 576 2 2
MIRT680186 ZNF554 zinc finger protein 554 2 2
MIRT684282 CDK9 cyclin dependent kinase 9 2 2
MIRT689671 RBM23 RNA binding motif protein 23 2 2
MIRT690031 CCDC90B coiled-coil domain containing 90B 2 2
MIRT691447 CXorf36 chromosome X open reading frame 36 2 2
MIRT691547 FLYWCH2 FLYWCH family member 2 2 2
MIRT691726 LARS leucyl-tRNA synthetase 2 2
MIRT692029 ARSK arylsulfatase family member K 2 2
MIRT692635 SUSD1 sushi domain containing 1 2 2
MIRT693823 BACE2 beta-site APP-cleaving enzyme 2 2 2
MIRT693864 IYD iodotyrosine deiodinase 2 2
MIRT693977 ZNF70 zinc finger protein 70 2 2
MIRT694145 CYP27C1 cytochrome P450 family 27 subfamily C member 1 2 2
MIRT695486 TRAT1 T-cell receptor associated transmembrane adaptor 1 2 2
MIRT695544 MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2 2 2
MIRT695599 TMEM199 transmembrane protein 199 2 2
MIRT696003 DNAJC10 DnaJ heat shock protein family (Hsp40) member C10 2 2
MIRT696020 TYRO3 TYRO3 protein tyrosine kinase 2 2
MIRT696039 KCNK6 potassium two pore domain channel subfamily K member 6 2 2
MIRT696310 NIP7 NIP7, nucleolar pre-rRNA processing protein 2 2
MIRT696400 CORO7 coronin 7 2 2
MIRT696595 ORMDL2 ORMDL sphingolipid biosynthesis regulator 2 2 2
MIRT698044 TRPM7 transient receptor potential cation channel subfamily M member 7 2 2
MIRT698139 TNRC6B trinucleotide repeat containing 6B 2 2
MIRT702561 KBTBD6 kelch repeat and BTB domain containing 6 2 2
MIRT703018 HEATR5A HEAT repeat containing 5A 2 2
MIRT705118 C4orf29 abhydrolase domain containing 18 2 2
MIRT706303 NT5C2 5'-nucleotidase, cytosolic II 2 2
MIRT706610 CYB5B cytochrome b5 type B 2 2
MIRT706729 RFK riboflavin kinase 2 2
MIRT707321 TMEM184B transmembrane protein 184B 2 2
MIRT708652 LYRM7 LYR motif containing 7 2 2
MIRT710520 NDUFV3 NADH:ubiquinone oxidoreductase subunit V3 2 2
MIRT714283 KIF1C kinesin family member 1C 2 2
MIRT720438 C19orf47 chromosome 19 open reading frame 47 2 2
MIRT720612 ZCCHC8 zinc finger CCHC-type containing 8 2 2
MIRT722756 SIRPB2 signal regulatory protein beta 2 2 2
MIRT723296 MOGAT1 monoacylglycerol O-acyltransferase 1 2 2
MIRT724380 NEK8 NIMA related kinase 8 2 2
MIRT725105 THRA thyroid hormone receptor, alpha 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-3663 Platinum-based doublet chemotherapy sensitive High Lung Adenocarcinoma tissue
hsa-mir-3663 Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-3663 Dabrafenib 44462760 NSC764134 approved resistant cell line (A375)
hsa-mir-3663 Cisplatin 5460033 NSC119875 approved sensitive cell line (CIS)
hsa-mir-3663 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-mir-3663 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-3663-5p Paclitaxel 36314 NSC125973 approved sensitive cell line (HS578T)
hsa-miR-3663-5p Doxorubicin 31703 NSC123127 approved sensitive cell line (HS578T)
hsa-miR-3663-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

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