pre-miRNA Information | |
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pre-miRNA | hsa-mir-4436b-1 |
Genomic Coordinates | chr2: 110086433 - 110086523 |
Description | Homo sapiens miR-4436b-1 stem-loop |
Comment | None |
RNA Secondary Structure | ![]() |
pre-miRNA | hsa-mir-4436b-2 |
Genomic Coordinates | chr2: 110284853 - 110284943 |
Description | Homo sapiens miR-4436b-2 stem-loop |
Comment | None |
RNA Secondary Structure | ![]() |
Mature miRNA Information | |||||||
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Mature miRNA | hsa-miR-4436b-3p | ||||||
Sequence | 60| CAGGGCAGGAAGAAGUGGACAA |81 | ||||||
Evidence | Experimental | ||||||
Experiments | Illumina | ||||||
SNPs in miRNA |
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Putative Targets |
miRNA Expression profile | |
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Human miRNA Tissue Atlas | |
Circulating MicroRNA Expression Profiling |
Gene Information | |||||||||||||||||||||
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Gene Symbol | EVX1 | ||||||||||||||||||||
Synonyms | EVX-1 | ||||||||||||||||||||
Description | even-skipped homeobox 1 | ||||||||||||||||||||
Transcript | NM_001989 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on EVX1 | |||||||||||||||||||||
3'UTR of EVX1 (miRNA target sites are highlighted) |
>EVX1|NM_001989|3'UTR 1 GGGGCCGCCGGCTGGCTGCCGGCTCCATGACGCCCGTGGGGTCACCCCCCGGCCCCGGGACTCAGCCAGCCTCGCTCCTC 81 GCTCCTCGCTCCTCGCCCCTAGGACGCCAAGGGGGAAAGGAGAGGGCGGAAAAGGACCAGCGGGATCCGGCCGCAAGAAT 161 TGGAAAGCCTAGGAAGTGGCGGTGGCTGGCGCGTTTGGGGAGCAGGAGTGGGGATAGGGAAGCAGAGCTTGAGAGACCTT 241 CCTCCGGGGCAGCCTCCGGACCCACCGCCCCCCACCAGGGTCGAGGCTGTAGCTCCAAAGCTAAACAAAACTTAGCAGCA 321 ACAGCAACCAATATCCAGTCCCTCGGCCCCTCGGCCCCTCACCCTCCACCTCACACTCCCTTCTCACCGGGCCCCCTCTC 401 CCCAGCCAAGGCCCAAGCACTGGAAAGGGAAATTGCTGTCTCTCTGAACAAAATGCTGTGTATGCAGAGCAGGTAGAGAT 481 TAATCTTTGCCAGCTTTTCCAAGGCATGACAAGGGGCTGGTGGATGGCAACATACCAGTCATTTGGAGGAGAGAGTGAGA 561 GATGATTTACTACCAGGGAGAATCCAGCCCCTTGGCATGGGACCTGGAGCCTCGACTACACAGCATCTTCTGGGTCTGGC 641 GTCTGCCAGCACCTGATCTCTTTCCTCATTCCCAGCTTTGTGACACTTCTCAACTTGCGGCTCCATCTCTCCCTGCCCCC721 ACTTTTTTGTTGGCCAGGGAGGCTGCAGATGCCCCAGGAGCCCTTTGCCGCTTCTATGAGGCCAAGCCTTTTTTCCCTGG 801 GCCCAGCACACACCCTGATTAGCAAGTGATGTGTGCGAGGAGGGTTTGTGAATGTTGAATGTGTAATAATGATCACCATG 881 GAGCTGGCCACTGACCCCAGAGCTGAGCTGTTAACAAGGCGCCCAGGGAAGAGCTTAGGGAGTGGGAACTTCACCTCCCT 961 CTCTCGGTATCTGGCGGTAAATTAGAGGCAATTTTCATCCTTTGCTTGTTCACCTTCACTTCACCAGGAACTTTCTGGCC 1041 CTACCCTTTGCATTGGGTATTTTACAACTTTCTCTCATTTTCTTCCCAAGCTACCACTGGAGCTTGACTTTCAGATACCA 1121 GTGGGAGCCTTCTGTCCCTTTTGGGGACCCTGTCTGTGGCCTCCACCAGGGTTTGTTTAGAGCCACTCCCAAATCCTCAC 1201 TCCCACACTCATCCTTGCAGCCAGTTTTTGAGGAAGAGGAGAACGTGTAACCCCAATGCAAGCTTCACCCTGACTGAGAG 1281 GGAGTGGTTCTTCCTGTAGGGAATGAATTTGGTTTGATTTGGGGTTTTCCTTTGAAGCCCAAAGAACTTGCTGTTATGAT 1361 TCGTTAACCATATTGCAATAAAAGCTGGACATAA Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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DRVs in gene 3'UTRs | |||||||||||||||||||||
SNPs in gene 3'UTRs |
Experimental Support 1 for Functional miRNA-Target Interaction | |||||||
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miRNA:Target | ---- | ||||||
Validation Method |
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Conditions | HEK293 | ||||||
Disease | 2128.0 | ||||||
Location of target site | 3'UTR | ||||||
Tools used in this research | TargetScan , miRTarCLIP , Piranha | ||||||
Original Description (Extracted from the article) |
...
"PAR-CLIP data was present in GSM1065668. RNA binding protein: AGO1. Condition:4-thiouridine
... - Memczak S; Jens M; Elefsinioti A; Torti F; et al., 2013, Nature. |
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miRNA-target interactions (Provided by authors) |
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Article |
- Memczak S; Jens M; Elefsinioti A; Torti F; et al. - Nature, 2013
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.
LinkOut: [PMID: 23446348]
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CLIP-seq Support 1 for dataset GSM1065668 | |
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Method / RBP | PAR-CLIP / AGO1 |
Cell line / Condition | HEK293 / 4-thiouridine, ML_MM_7 |
Location of target site | ENST00000222761.3 | 3UTR | gcccuaccccuucccaucgc |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23446348 / GSE43573 |
CLIP-seq Viewer | Link |
MiRNA-Target Expression Profile | |||||||
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MiRNA-Target Expression Profile (TCGA) | |||||||
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87 hsa-miR-4436b-3p Target Genes:
Functional analysis:
ID![]() |
Target | Description | Validation methods |
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Strong evidence | Less strong evidence | |||||||||||
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MIRT066957 | ATXN7L3B | ataxin 7 like 3B | ![]() |
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2 | 8 | ||||||
MIRT119284 | NABP1 | nucleic acid binding protein 1 | ![]() |
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2 | 6 | ||||||
MIRT128915 | KMT2A | lysine methyltransferase 2A | ![]() |
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2 | 2 | ||||||
MIRT150116 | MIDN | midnolin | ![]() |
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2 | 2 | ||||||
MIRT173040 | YTHDF3 | YTH N6-methyladenosine RNA binding protein 3 | ![]() |
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2 | 2 | ||||||
MIRT253117 | BCL2L12 | BCL2 like 12 | ![]() |
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2 | 2 | ||||||
MIRT256997 | RGMB | repulsive guidance molecule family member b | ![]() |
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2 | 2 | ||||||
MIRT259746 | SNX12 | sorting nexin 12 | ![]() |
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2 | 2 | ||||||
MIRT267278 | TMEM109 | transmembrane protein 109 | ![]() |
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2 | 2 | ||||||
MIRT441934 | C1orf109 | chromosome 1 open reading frame 109 | ![]() |
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2 | 2 | ||||||
MIRT443625 | CPSF2 | cleavage and polyadenylation specific factor 2 | ![]() |
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2 | 2 | ||||||
MIRT445757 | AGO1 | argonaute 1, RISC catalytic component | ![]() |
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2 | 2 | ||||||
MIRT447835 | CTIF | cap binding complex dependent translation initiation factor | ![]() |
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2 | 2 | ||||||
MIRT451230 | ZNF444 | zinc finger protein 444 | ![]() |
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2 | 2 | ||||||
MIRT451966 | TMPRSS5 | transmembrane protease, serine 5 | ![]() |
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2 | 2 | ||||||
MIRT453127 | HOXC4 | homeobox C4 | ![]() |
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2 | 2 | ||||||
MIRT454604 | RPL13A | ribosomal protein L13a | ![]() |
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2 | 2 | ||||||
MIRT455176 | SUV39H1 | suppressor of variegation 3-9 homolog 1 | ![]() |
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2 | 2 | ||||||
MIRT455547 | GJB1 | gap junction protein beta 1 | ![]() |
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2 | 2 | ||||||
MIRT458197 | ATP6V0A2 | ATPase H+ transporting V0 subunit a2 | ![]() |
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2 | 2 | ||||||
MIRT458356 | NOC2L | NOC2 like nucleolar associated transcriptional repressor | ![]() |
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2 | 2 | ||||||
MIRT458923 | DNM2 | dynamin 2 | ![]() |
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2 | 2 | ||||||
MIRT461013 | SYT7 | synaptotagmin 7 | ![]() |
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2 | 2 | ||||||
MIRT461643 | ZSWIM4 | zinc finger SWIM-type containing 4 | ![]() |
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2 | 2 | ||||||
MIRT461997 | PACSIN1 | protein kinase C and casein kinase substrate in neurons 1 | ![]() |
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2 | 2 | ||||||
MIRT462367 | BCL7B | BCL tumor suppressor 7B | ![]() |
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2 | 2 | ||||||
MIRT464915 | TXNIP | thioredoxin interacting protein | ![]() |
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2 | 2 | ||||||
MIRT466311 | TIMM22 | translocase of inner mitochondrial membrane 22 | ![]() |
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2 | 2 | ||||||
MIRT466591 | TBC1D2B | TBC1 domain family member 2B | ![]() |
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2 | 2 | ||||||
MIRT467045 | SRSF1 | serine and arginine rich splicing factor 1 | ![]() |
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2 | 2 | ||||||
MIRT468750 | SDC2 | syndecan 2 | ![]() |
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2 | 2 | ||||||
MIRT468943 | RPS24 | ribosomal protein S24 | ![]() |
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2 | 2 | ||||||
MIRT469474 | REEP5 | receptor accessory protein 5 | ![]() |
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2 | 2 | ||||||
MIRT469913 | PTRF | caveolae associated protein 1 | ![]() |
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2 | 2 | ||||||
MIRT473325 | MEX3A | mex-3 RNA binding family member A | ![]() |
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2 | 2 | ||||||
MIRT473643 | MARK2 | microtubule affinity regulating kinase 2 | ![]() |
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2 | 2 | ||||||
MIRT474064 | LMNB2 | lamin B2 | ![]() |
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2 | 2 | ||||||
MIRT474357 | KMT2D | lysine methyltransferase 2D | ![]() |
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2 | 2 | ||||||
MIRT475394 | ICMT | isoprenylcysteine carboxyl methyltransferase | ![]() |
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2 | 4 | ||||||
MIRT476335 | GLTSCR1L | BRD4 interacting chromatin remodeling complex associated protein like | ![]() |
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2 | 2 | ||||||
MIRT478651 | CTDNEP1 | CTD nuclear envelope phosphatase 1 | ![]() |
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2 | 2 | ||||||
MIRT479585 | CDC42SE1 | CDC42 small effector 1 | ![]() |
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2 | 2 | ||||||
MIRT479943 | CBX5 | chromobox 5 | ![]() |
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2 | 2 | ||||||
MIRT482001 | AMOTL2 | angiomotin like 2 | ![]() |
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2 | 2 | ||||||
MIRT482043 | AMER1 | APC membrane recruitment protein 1 | ![]() |
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2 | 2 | ||||||
MIRT483070 | EXT2 | exostosin glycosyltransferase 2 | ![]() |
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2 | 6 | ||||||
MIRT484323 | KCNH1 | potassium voltage-gated channel subfamily H member 1 | ![]() |
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2 | 4 | ||||||
MIRT487528 | GXYLT2 | glucoside xylosyltransferase 2 | ![]() |
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2 | 2 | ||||||
MIRT489636 | ALS2CL | ALS2 C-terminal like | ![]() |
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2 | 2 | ||||||
MIRT490693 | SSTR1 | somatostatin receptor 1 | ![]() |
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2 | 2 | ||||||
MIRT490871 | UPK2 | uroplakin 2 | ![]() |
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2 | 2 | ||||||
MIRT492582 | PPM1L | protein phosphatase, Mg2+/Mn2+ dependent 1L | ![]() |
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2 | 2 | ||||||
MIRT492945 | NEUROD2 | neuronal differentiation 2 | ![]() |
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2 | 2 | ||||||
MIRT498675 | SOD2 | superoxide dismutase 2 | ![]() |
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2 | 4 | ||||||
MIRT499349 | RAB25 | RAB25, member RAS oncogene family | ![]() |
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2 | 2 | ||||||
MIRT502338 | GIGYF1 | GRB10 interacting GYF protein 1 | ![]() |
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2 | 4 | ||||||
MIRT502976 | CCNL1 | cyclin L1 | ![]() |
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2 | 8 | ||||||
MIRT503706 | NUP62 | nucleoporin 62 | ![]() |
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2 | 2 | ||||||
MIRT505567 | SMUG1 | single-strand-selective monofunctional uracil-DNA glycosylase 1 | ![]() |
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2 | 2 | ||||||
MIRT507808 | CDKN1B | cyclin dependent kinase inhibitor 1B | ![]() |
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2 | 2 | ||||||
MIRT513242 | FBXO41 | F-box protein 41 | ![]() |
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2 | 6 | ||||||
MIRT513586 | EVX1 | even-skipped homeobox 1 | ![]() |
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2 | 2 | ||||||
MIRT525036 | FRK | fyn related Src family tyrosine kinase | ![]() |
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2 | 2 | ||||||
MIRT531035 | TDGF1P3 | teratocarcinoma-derived growth factor 1 pseudogene 3 | ![]() |
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2 | 2 | ||||||
MIRT531939 | RBMS2 | RNA binding motif single stranded interacting protein 2 | ![]() |
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2 | 2 | ||||||
MIRT534912 | PUM2 | pumilio RNA binding family member 2 | ![]() |
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2 | 2 | ||||||
MIRT535717 | N4BP1 | NEDD4 binding protein 1 | ![]() |
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2 | 2 | ||||||
MIRT540498 | ZMAT4 | zinc finger matrin-type 4 | ![]() |
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2 | 4 | ||||||
MIRT541465 | AURKA | aurora kinase A | ![]() |
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2 | 2 | ||||||
MIRT554328 | SH3GLB1 | SH3 domain containing GRB2 like, endophilin B1 | ![]() |
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2 | 2 | ||||||
MIRT561572 | SLC6A9 | solute carrier family 6 member 9 | ![]() |
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2 | 2 | ||||||
MIRT564715 | ZNF322P1 | zinc finger protein 322 pseudogene 1 | ![]() |
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2 | 2 | ||||||
MIRT576176 | Hmox1 | heme oxygenase 1 | ![]() |
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2 | 2 | ||||||
MIRT629712 | XKR4 | XK related 4 | ![]() |
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2 | 2 | ||||||
MIRT636182 | THBD | thrombomodulin | ![]() |
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2 | 2 | ||||||
MIRT646315 | MPHOSPH8 | M-phase phosphoprotein 8 | ![]() |
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2 | 2 | ||||||
MIRT649174 | IQSEC1 | IQ motif and Sec7 domain 1 | ![]() |
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2 | 2 | ||||||
MIRT666945 | PMEPA1 | prostate transmembrane protein, androgen induced 1 | ![]() |
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2 | 2 | ||||||
MIRT684057 | FOLR1 | folate receptor 1 | ![]() |
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2 | 2 | ||||||
MIRT687585 | MAU2 | MAU2 sister chromatid cohesion factor | ![]() |
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2 | 2 | ||||||
MIRT689953 | ZNF185 | zinc finger protein 185 with LIM domain | ![]() |
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2 | 2 | ||||||
MIRT704071 | SRCAP | Snf2 related CREBBP activator protein | ![]() |
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2 | 2 | ||||||
MIRT704327 | DCUN1D5 | defective in cullin neddylation 1 domain containing 5 | ![]() |
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2 | 2 | ||||||
MIRT705406 | ATP1B3 | ATPase Na+/K+ transporting subunit beta 3 | ![]() |
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2 | 2 | ||||||
MIRT710488 | CDH5 | cadherin 5 | ![]() |
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2 | 2 | ||||||
MIRT718241 | LCE1A | late cornified envelope 1A | ![]() |
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2 | 2 | ||||||
MIRT723182 | CDCA4 | cell division cycle associated 4 | ![]() |
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2 | 2 |