miRTarBase - #MIRT513609


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pre-miRNA Information
pre-miRNA hsa-mir-378c   
Genomic Coordinates chr10: 130962588 - 130962668
Description Homo sapiens miR-378c stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-378c
Sequence 11| ACUGGACUUGGAGUCAGAAGAGUGG |35
Evidence Experimental
Experiments SOLiD
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 12 10 - 130962647 29233923 MiREDiBase
A-to-I 21 10 - 130962638 22327324, 27229138, 29165639 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1255712575 1 dbSNP
rs954998865 5 dbSNP
rs1476405711 7 dbSNP
rs1187159745 11 dbSNP
rs936928990 13 dbSNP
rs924224817 14 dbSNP
rs1031754294 22 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol VPS37B   
Synonyms -
Description VPS37B, ESCRT-I subunit
Transcript NM_024667   
Expression
Putative miRNA Targets on VPS37B
3'UTR of VPS37B
(miRNA target sites are highlighted)		 
>VPS37B|NM_024667|3'UTR
   1 GCGCCGGCGCGGTCCTTCCCGGGAGACTTCTTCCACCTGGCGTGTTGTGCTCTGCTCACGGGAAGGAGGCTGGAGGTCCG
  81 CTCTGTGCCAAGGGCTCTGGGGCCCTGGGCCAGCGTGTCTGTCTGATTTTAGAACTGTAGGTCAGTGGTGAGTAGTAGGA
 161 GCCCAGGCTTTGGGCATCAAGGCAGTTGTGTGTGCCGGGTTACAGCCTGACACCTGTGCGTTGCATCGGTTTGCATTATC
 241 CGTGTGATTTCTAAGTATCTTAGCGTTGATGAACTCATGTTTGGGAAGAAATAGGCCTCTCCCCCAGTCCCATTTAGAAT
 321 CGTGGTCCTTCTGTTGCAGCTTTATTTAATGAGCATGGTTCATGATACTTATTTTATTTTCGAAAGACAGTCCTATGTGT
 401 CTCACCCACCGGCCACTGCAGCCCTGGTGAGGGCGGGTGGGCGCCGGCCGGCCTGGAAGAGCGCCGTGGCTGGGCCACCA
 481 CCTGTGGCTGCGTTGTTGCTCACTGAATCTGTTGGGGAGAGGTCACCATAGTCACCGCCTGACCTGGCTGCTGCTCTTGC
 561 TTCAGAGCCACAAGCAAAGTTTGCACTGGGCCCACTGCCGAGTCCAGAGGCCGGAGAACGGCCACTGGTGTGGGAGGGGA
 641 GCGCACGAGTGGGACTTTGCACAGCAAATTGTGTCCCCAGCTCCTCCTCTCCCGCCTGCCTGGAGCCGGCCCTGAAGGTT
 721 TCTATGAAGAAATAATCCCCCAATATTTTTACTACGTGTGTGATTTTCCTGTTTTATATTGAAAAAACTTTTTTGACACT
 801 CCCAAGACCATTCAGGGAAATTTTATAAAAAATGCAGATACTGTCTTGAGCAGATCGAAATGCCGATGAAGTGGATGCAA
 881 TTTCCTTTTGTGCAAGCAGTGCACGGTGCCCCCCCCTCGGGTGTCCGTGCTGTGCCTTAGCTTCCCCAGGTGCCGGGACT
 961 CACACCTGCTAGGGGCTGGGCAAGGCCCCGGCTCTGCTTTCTCTGAAGGGCTTGTCCAAGTTCATTGCCCTGTTACAGGT
1041 GGTCAAGACGTCCGGCCGCCTTGACCCAGGCTACCCTTAGCCAATATCCTCTGCCCCTGGGTGGCTGGTGGCTGGGCCTC
1121 AGGGTGGGCAACGTTAGGGGTTTGGCGAAAGCCCGCCCCATGGGATTGAGGGACGGGGCTGCACTCCAACCGTCTGCACC
1201 TGCTCTTCCCCCACCCCTGTGGGACCTCATCTTCACGTGCCATGTGTGCTGAAGGCCCAGGGCCCAGCAGGGGGCAGTGG
1281 CACCTGTTGACGGAAAAGGCCGAGGTGCTTACCAGTGGACCTTCTGGCCCGCCCCTCCCCTGTCACTTGTCGGGCATCCA
1361 GGGCCCCGACCTGTGCCTAGCCGCCAGGGTGACAGAAGGCAGAACTGAAGCGGGGTCTGGGCCACGGGCCAGGCCACTGC
1441 CTTTTGTCCTCAGTGACCGTACATTCCTGCTCTCGGACTTGAACTCTACTGTAACTGTTTTCTTAAAGGAAATGAAGCTG
1521 TACAGGACGATTCACTGCCATGCCAGTCAGGCGGGCTTGCCATGTTCTGTGAATCTCGAGTGAGCGGTGCCACCCGCCCC
1601 CATACCTCCGCCACCGGCCGCTGTCGGGGATGCCACAGCCTGCCACGGTCGCAGCCAGACGTGAGCTTGGCATTGAAGTT
1681 GCAAAGCGGCCCCTGGCCGGGCTCGCCGTCGCTGTCCAGGGCCGTGTCCGGTGCTGTGGCTGTAAAGCTGTAGGACCCTT
1761 TTTAATAAATAGAGAATTATTAATAACAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' ggUGAGAAGACUGA-GGUUCAGGUCa 5'
            |||   |  ||| ||:||||||| 
Target 5' gcACTGGGCCCACTGCCGAGTCCAGa 3'
 583 - 608 163.00 -24.10
2 
miRNA  3' ggUGAGAAGAC--UGA-GGUUCAGGUca 5'
            |||:||:||  ||| ||||| |||  
Target 5' aaACTTTTTTGACACTCCCAAGACCAtt 3'
 785 - 812 137.00 -19.40
3 
miRNA  3' ggUGAGA-AGACU----G---AGGUUCAGGUca 5'
            :||:| |||||    |   |||||||:||  
Target 5' ctGCTTTCTCTGAAGGGCTTGTCCAAGTTCAtt 3'
 994 - 1026 137.00 -18.30
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30112520 14 COSMIC
COSN29081409 189 COSMIC
COSN30138134 197 COSMIC
COSN31536578 440 COSMIC
COSN31518022 450 COSMIC
COSN31589735 465 COSMIC
COSN31550946 526 COSMIC
COSN31487743 556 COSMIC
COSN31537918 643 COSMIC
COSN31537920 781 COSMIC
COSN31596795 839 COSMIC
COSN30176829 853 COSMIC
COSN31539170 904 COSMIC
COSN31556097 908 COSMIC
COSN31541959 954 COSMIC
COSN31960861 1267 COSMIC
COSN15411371 1475 COSMIC
COSN21489477 1475 COSMIC
COSN20110287 1505 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs758146488 2 dbSNP
rs765374829 2 dbSNP
rs755035600 3 dbSNP
rs542997491 4 dbSNP
rs766370328 5 dbSNP
rs531661708 6 dbSNP
rs750349526 8 dbSNP
rs745488944 9 dbSNP
rs767301365 9 dbSNP
rs371130963 10 dbSNP
rs774127047 11 dbSNP
rs763900367 13 dbSNP
rs1209675128 17 dbSNP
rs199569762 20 dbSNP
rs776775624 21 dbSNP
rs1047888269 23 dbSNP
rs775074332 24 dbSNP
rs377731980 25 dbSNP
rs747505752 26 dbSNP
rs1185397067 27 dbSNP
rs1417070149 30 dbSNP
rs1356497483 34 dbSNP
rs373117795 41 dbSNP
rs546041008 42 dbSNP
rs1057026666 47 dbSNP
rs1355870294 48 dbSNP
rs748566789 49 dbSNP
rs779100363 51 dbSNP
rs1279069076 54 dbSNP
rs1003132182 59 dbSNP
rs898050426 60 dbSNP
rs1036547565 70 dbSNP
rs572154337 79 dbSNP
rs926888750 80 dbSNP
rs1302971641 83 dbSNP
rs942181165 85 dbSNP
rs1045345753 86 dbSNP
rs191396248 89 dbSNP
rs1352149856 98 dbSNP
rs1166202991 100 dbSNP
rs1293718794 100 dbSNP
rs887557664 109 dbSNP
rs1050168467 110 dbSNP
rs1214921514 110 dbSNP
rs946947663 111 dbSNP
rs1486530467 114 dbSNP
rs553960730 115 dbSNP
rs1422365248 119 dbSNP
rs1444909003 124 dbSNP
rs989772761 126 dbSNP
rs1387417805 144 dbSNP
rs955780721 147 dbSNP
rs1399352148 148 dbSNP
rs1158933722 152 dbSNP
rs145054642 156 dbSNP
rs1455398718 158 dbSNP
rs189609691 163 dbSNP
rs574174294 164 dbSNP
rs1190440829 165 dbSNP
rs1488729177 173 dbSNP
rs965928371 175 dbSNP
rs1317451680 186 dbSNP
rs1202426838 192 dbSNP
rs1017842391 197 dbSNP
rs1317375378 198 dbSNP
rs760985855 199 dbSNP
rs1318732878 206 dbSNP
rs141247814 215 dbSNP
rs772482607 216 dbSNP
rs1461398215 219 dbSNP
rs1205131004 220 dbSNP
rs952053470 223 dbSNP
rs537031814 227 dbSNP
rs1177048936 231 dbSNP
rs1409346082 241 dbSNP
rs993426253 242 dbSNP
rs897928592 255 dbSNP
rs1282992421 258 dbSNP
rs1056451836 264 dbSNP
rs570005715 265 dbSNP
rs905390746 269 dbSNP
rs1279967290 275 dbSNP
rs1375417482 276 dbSNP
rs1035675009 277 dbSNP
rs1045635694 290 dbSNP
rs1323539201 296 dbSNP
rs946989630 305 dbSNP
rs558183722 306 dbSNP
rs1442202971 309 dbSNP
rs1054134165 310 dbSNP
rs1481834764 313 dbSNP
rs898107966 315 dbSNP
rs1197839232 318 dbSNP
rs748770301 321 dbSNP
rs1480799083 322 dbSNP
rs934290850 324 dbSNP
rs1015574531 332 dbSNP
rs1402877051 334 dbSNP
rs924254790 342 dbSNP
rs975858187 344 dbSNP
rs777431213 349 dbSNP
rs1006427270 353 dbSNP
rs1346136717 354 dbSNP
rs1224812661 359 dbSNP
rs1426776027 361 dbSNP
rs887935407 366 dbSNP
rs138200728 368 dbSNP
rs931722460 369 dbSNP
rs986329755 372 dbSNP
rs1220734035 381 dbSNP
rs761360321 381 dbSNP
rs1268798026 386 dbSNP
rs754038915 390 dbSNP
rs952005918 394 dbSNP
rs370919593 395 dbSNP
rs901569050 410 dbSNP
rs1027500876 411 dbSNP
rs565979285 412 dbSNP
rs150394734 419 dbSNP
rs1427091904 425 dbSNP
rs184836134 426 dbSNP
rs1422501854 429 dbSNP
rs1162768320 434 dbSNP
rs1366078793 435 dbSNP
rs923921555 442 dbSNP
rs567793215 443 dbSNP
rs1003666967 445 dbSNP
rs115857308 446 dbSNP
rs374430876 449 dbSNP
rs564067318 450 dbSNP
rs1011461821 462 dbSNP
rs894079367 463 dbSNP
rs990592657 465 dbSNP
rs879348213 466 dbSNP
rs1052709890 470 dbSNP
rs193052255 472 dbSNP
rs188684506 475 dbSNP
rs1040442333 478 dbSNP
rs560431574 484 dbSNP
rs962348885 489 dbSNP
rs944475016 491 dbSNP
rs910260339 492 dbSNP
rs1331352881 493 dbSNP
rs1015209092 501 dbSNP
rs542032163 503 dbSNP
rs1385577545 510 dbSNP
rs985996695 512 dbSNP
rs1156670001 515 dbSNP
rs1403342018 516 dbSNP
rs1400767591 517 dbSNP
rs1319767108 518 dbSNP
rs930450614 520 dbSNP
rs1006890155 522 dbSNP
rs920412067 525 dbSNP
rs1315352790 528 dbSNP
rs1383901039 530 dbSNP
rs1301896204 535 dbSNP
rs76742815 536 dbSNP
rs562185458 537 dbSNP
rs1360665369 540 dbSNP
rs961930827 544 dbSNP
rs1205755979 547 dbSNP
rs1270146773 550 dbSNP
rs1156691524 556 dbSNP
rs1034985055 560 dbSNP
rs1203224871 580 dbSNP
rs543864891 586 dbSNP
rs756132919 595 dbSNP
rs1446166145 599 dbSNP
rs550000193 600 dbSNP
rs1442840344 601 dbSNP
rs1024115132 612 dbSNP
rs1010971329 613 dbSNP
rs1484387681 614 dbSNP
rs901621352 619 dbSNP
rs3825142 620 dbSNP
rs894007188 622 dbSNP
rs1407921583 626 dbSNP
rs1398154326 630 dbSNP
rs902186498 642 dbSNP
rs1031167393 643 dbSNP
rs999818194 647 dbSNP
rs183229535 659 dbSNP
rs1321417991 660 dbSNP
rs1054914670 661 dbSNP
rs193000965 662 dbSNP
rs944343758 669 dbSNP
rs1249500078 671 dbSNP
rs1438219490 672 dbSNP
rs1184176693 679 dbSNP
rs1427131960 681 dbSNP
rs928764490 690 dbSNP
rs1176613931 693 dbSNP
rs754778502 693 dbSNP
rs1050624292 694 dbSNP
rs930384494 696 dbSNP
rs962117055 700 dbSNP
rs751331319 707 dbSNP
rs1392337741 719 dbSNP
rs920464515 727 dbSNP
rs1360991743 729 dbSNP
rs1404405242 731 dbSNP
rs1160377047 737 dbSNP
rs1314048154 739 dbSNP
rs971871254 755 dbSNP
rs1367943042 756 dbSNP
rs572388753 758 dbSNP
rs575818711 763 dbSNP
rs1199479897 764 dbSNP
rs1268778269 773 dbSNP
rs927839591 776 dbSNP
rs1426250807 777 dbSNP
rs982152007 778 dbSNP
rs969816082 781 dbSNP
rs916571745 786 dbSNP
rs1169226514 790 dbSNP
rs1193290529 791 dbSNP
rs990003940 792 dbSNP
rs187936690 793 dbSNP
rs1364216590 795 dbSNP
rs758334421 801 dbSNP
rs1288656331 803 dbSNP
rs1369741184 811 dbSNP
rs553972242 814 dbSNP
rs1295111099 819 dbSNP
rs1019080657 820 dbSNP
rs1031177479 830 dbSNP
rs750444162 832 dbSNP
rs1230303185 833 dbSNP
rs1289388594 838 dbSNP
rs767844133 840 dbSNP
rs765286983 842 dbSNP
rs1267151120 846 dbSNP
rs535674500 854 dbSNP
rs1007125530 856 dbSNP
rs151210557 857 dbSNP
rs142186858 864 dbSNP
rs994587859 865 dbSNP
rs1275895693 866 dbSNP
rs762296523 866 dbSNP
rs898883385 877 dbSNP
rs533206267 878 dbSNP
rs1166039233 880 dbSNP
rs1340861518 885 dbSNP
rs537897136 887 dbSNP
rs1288406868 889 dbSNP
rs570397238 892 dbSNP
rs1389929226 893 dbSNP
rs1313227281 895 dbSNP
rs940787319 897 dbSNP
rs1314750426 901 dbSNP
rs1315122356 902 dbSNP
rs927799378 904 dbSNP
rs1046772844 910 dbSNP
rs1465888936 913 dbSNP
rs947988011 914 dbSNP
rs952006669 914 dbSNP
rs552143485 915 dbSNP
rs182307500 916 dbSNP
rs1458889596 917 dbSNP
rs563133724 917 dbSNP
rs142166071 918 dbSNP
rs923993324 919 dbSNP
rs1197747976 926 dbSNP
rs1451468355 927 dbSNP
rs1223093417 929 dbSNP
rs754059998 932 dbSNP
rs1307627574 939 dbSNP
rs1330537052 948 dbSNP
rs978275489 949 dbSNP
rs1212208988 950 dbSNP
rs965561041 954 dbSNP
rs1019769127 955 dbSNP
rs1010569412 956 dbSNP
rs764528323 959 dbSNP
rs1479880119 970 dbSNP
rs1177066332 972 dbSNP
rs1413360659 980 dbSNP
rs1033271110 981 dbSNP
rs560460911 985 dbSNP
rs759299142 989 dbSNP
rs548478800 990 dbSNP
rs529930833 996 dbSNP
rs562663546 998 dbSNP
rs543557563 1003 dbSNP
rs576470876 1006 dbSNP
rs1308550942 1012 dbSNP
rs534240045 1013 dbSNP
rs189624936 1017 dbSNP
rs1004574432 1020 dbSNP
rs1324125022 1025 dbSNP
rs1388490845 1035 dbSNP
rs1323654760 1036 dbSNP
rs906391968 1037 dbSNP
rs564357421 1038 dbSNP
rs377329448 1044 dbSNP
rs1204336415 1049 dbSNP
rs761052804 1050 dbSNP
rs372468083 1051 dbSNP
rs147596034 1053 dbSNP
rs944967042 1054 dbSNP
rs554057123 1057 dbSNP
rs772642906 1058 dbSNP
rs1417713215 1079 dbSNP
rs1409154912 1082 dbSNP
rs1436627011 1084 dbSNP
rs936633022 1088 dbSNP
rs1197493171 1093 dbSNP
rs966903257 1095 dbSNP
rs1422615943 1105 dbSNP
rs1302508430 1106 dbSNP
rs1457888686 1108 dbSNP
rs1259576192 1109 dbSNP
rs535708283 1110 dbSNP
rs1217188959 1113 dbSNP
rs923921028 1115 dbSNP
rs770534528 1116 dbSNP
rs989196430 1116 dbSNP
rs959075088 1124 dbSNP
rs574693065 1132 dbSNP
rs1275853881 1133 dbSNP
rs944130614 1137 dbSNP
rs879682502 1138 dbSNP
rs912764412 1142 dbSNP
rs985609822 1146 dbSNP
rs1004491500 1147 dbSNP
rs888278366 1154 dbSNP
rs373493867 1157 dbSNP
rs1475237262 1159 dbSNP
rs1027167855 1163 dbSNP
rs1308535930 1166 dbSNP
rs1391745247 1169 dbSNP
rs760137696 1171 dbSNP
rs1162785358 1172 dbSNP
rs775059851 1174 dbSNP
rs974275458 1175 dbSNP
rs1315660719 1179 dbSNP
rs1402617545 1181 dbSNP
rs1332428548 1182 dbSNP
rs556711696 1188 dbSNP
rs930734383 1191 dbSNP
rs1299401153 1192 dbSNP
rs900559814 1192 dbSNP
rs1284122477 1193 dbSNP
rs1357724697 1197 dbSNP
rs1403328115 1202 dbSNP
rs769393941 1203 dbSNP
rs1350572574 1209 dbSNP
rs1014535079 1210 dbSNP
rs541133005 1212 dbSNP
rs1209528442 1213 dbSNP
rs186559244 1214 dbSNP
rs1459801510 1215 dbSNP
rs1182825635 1217 dbSNP
rs912172163 1219 dbSNP
rs1473764858 1220 dbSNP
rs1025235980 1223 dbSNP
rs1012053339 1225 dbSNP
rs895074056 1232 dbSNP
rs768221962 1236 dbSNP
rs145113475 1237 dbSNP
rs902551101 1242 dbSNP
rs1333979585 1243 dbSNP
rs1341472294 1244 dbSNP
rs1247579783 1257 dbSNP
rs183331099 1262 dbSNP
rs1328505749 1263 dbSNP
rs1229150671 1268 dbSNP
rs1270243170 1275 dbSNP
rs1441512474 1275 dbSNP
rs1460179857 1275 dbSNP
rs533794702 1279 dbSNP
rs566440615 1282 dbSNP
rs1256533119 1283 dbSNP
rs912616530 1291 dbSNP
rs746450154 1292 dbSNP
rs1351337864 1294 dbSNP
rs932855948 1301 dbSNP
rs566738683 1302 dbSNP
rs920066886 1308 dbSNP
rs1240866458 1314 dbSNP
rs529969541 1320 dbSNP
rs1033375153 1321 dbSNP
rs1468921890 1324 dbSNP
rs1172837473 1325 dbSNP
rs982208629 1329 dbSNP
rs1379165778 1330 dbSNP
rs974306174 1331 dbSNP
rs970415268 1334 dbSNP
rs1015960199 1337 dbSNP
rs534057522 1342 dbSNP
rs952715288 1343 dbSNP
rs1336483793 1346 dbSNP
rs1026833098 1349 dbSNP
rs996669708 1351 dbSNP
rs900613950 1352 dbSNP
rs1273790115 1354 dbSNP
rs879583142 1367 dbSNP
rs1266106514 1368 dbSNP
rs1479828538 1368 dbSNP
rs961569918 1375 dbSNP
rs117865374 1380 dbSNP
rs983131205 1382 dbSNP
rs1467894696 1383 dbSNP
rs550735130 1383 dbSNP
rs1370458172 1395 dbSNP
rs1304616869 1400 dbSNP
rs1430897129 1402 dbSNP
rs1310420803 1406 dbSNP
rs139523950 1411 dbSNP
rs144454269 1412 dbSNP
rs1050280 1417 dbSNP
rs1487185221 1425 dbSNP
rs1053907802 1428 dbSNP
rs1285097312 1429 dbSNP
rs1333089399 1430 dbSNP
rs545858749 1439 dbSNP
rs1224939938 1446 dbSNP
rs1273592600 1451 dbSNP
rs1032142634 1453 dbSNP
rs12255 1459 dbSNP
rs902427312 1463 dbSNP
rs1287766123 1474 dbSNP
rs561740809 1475 dbSNP
rs944037439 1476 dbSNP
rs891099782 1477 dbSNP
rs1357213074 1481 dbSNP
rs1187559866 1484 dbSNP
rs1286172196 1489 dbSNP
rs1049852413 1490 dbSNP
rs1398427946 1495 dbSNP
rs1170966145 1500 dbSNP
rs542161331 1501 dbSNP
rs1299213320 1502 dbSNP
rs111540677 1505 dbSNP
rs1457445821 1508 dbSNP
rs200642841 1508 dbSNP
rs773210338 1508 dbSNP
rs35135213 1509 dbSNP
rs764102802 1509 dbSNP
rs201541832 1512 dbSNP
rs1392998191 1514 dbSNP
rs1380705077 1524 dbSNP
rs149654682 1528 dbSNP
rs556516647 1529 dbSNP
rs952636284 1531 dbSNP
rs940312578 1533 dbSNP
rs1230414181 1536 dbSNP
rs908786211 1541 dbSNP
rs1321085547 1543 dbSNP
rs112048296 1545 dbSNP
rs1413978626 1548 dbSNP
rs970437833 1550 dbSNP
rs1484622417 1552 dbSNP
rs1207637930 1553 dbSNP
rs917544591 1574 dbSNP
rs1166611394 1577 dbSNP
rs1465617749 1578 dbSNP
rs996723792 1578 dbSNP
rs1476665169 1580 dbSNP
rs1423694904 1585 dbSNP
rs867276397 1585 dbSNP
rs959070006 1586 dbSNP
rs963867868 1588 dbSNP
rs80271217 1595 dbSNP
rs1000690911 1596 dbSNP
rs1389749345 1599 dbSNP
rs1008988082 1600 dbSNP
rs890511222 1601 dbSNP
rs1378196372 1602 dbSNP
rs966643347 1605 dbSNP
rs558637573 1609 dbSNP
rs1008535503 1610 dbSNP
rs1244923548 1611 dbSNP
rs891138123 1615 dbSNP
rs150902425 1616 dbSNP
rs996982043 1619 dbSNP
rs898578093 1620 dbSNP
rs1038533892 1622 dbSNP
rs1216974362 1623 dbSNP
rs754738329 1625 dbSNP
rs566478792 1626 dbSNP
rs1158579300 1628 dbSNP
rs1412941549 1631 dbSNP
rs908692264 1635 dbSNP
rs142195758 1646 dbSNP
rs1297133645 1647 dbSNP
rs138948256 1650 dbSNP
rs1371177537 1651 dbSNP
rs938214310 1658 dbSNP
rs146102479 1660 dbSNP
rs1046976031 1661 dbSNP
rs917592701 1664 dbSNP
rs908277231 1666 dbSNP
rs1311965359 1667 dbSNP
rs1437863097 1673 dbSNP
rs1211352856 1674 dbSNP
rs1258255188 1675 dbSNP
rs1349937440 1678 dbSNP
rs1182115971 1681 dbSNP
rs1252573781 1682 dbSNP
rs569111187 1686 dbSNP
rs550571978 1687 dbSNP
rs1424796112 1688 dbSNP
rs925008427 1698 dbSNP
rs532352372 1699 dbSNP
rs975338185 1700 dbSNP
rs979154783 1701 dbSNP
rs1422479077 1702 dbSNP
rs966548603 1704 dbSNP
rs571310436 1705 dbSNP
rs954844663 1707 dbSNP
rs1008150179 1710 dbSNP
rs552253561 1711 dbSNP
rs1220159061 1714 dbSNP
rs1303795719 1718 dbSNP
rs1422847788 1723 dbSNP
rs1275987959 1724 dbSNP
rs1028359676 1725 dbSNP
rs767984052 1728 dbSNP
rs996789676 1729 dbSNP
rs373356948 1730 dbSNP
rs527774952 1733 dbSNP
rs1038434826 1735 dbSNP
rs1002413160 1737 dbSNP
rs1169129616 1758 dbSNP
rs1254922235 1770 dbSNP
rs1403070097 1773 dbSNP
rs905414554 1774 dbSNP
rs1196830969 1776 dbSNP
rs1349988523 1776 dbSNP
rs1046588849 1777 dbSNP
rs1363392389 1783 dbSNP
rs1228204373 1785 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 79720.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM1065668. RNA binding protein: AGO1. Condition:4-thiouridine ...

- Memczak S; Jens M; Elefsinioti A; Torti F; et al., 2013, Nature.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' ggUGAGAAGACUGA-GGUUCAGGuca 5'
            |||   |  ||| ||:|||||   
Target 5' gcACUGGGCCCACUGCCGAGUCC--- 3'
 		4 - 26
Article - Memczak S; Jens M; Elefsinioti A; Torti F; et al.
- Nature, 2013
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.
LinkOut: [PMID: 23446348]
CLIP-seq Support 1 for dataset GSM4903833
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_a
Location of target site NM_024667 | 3UTR | UCCAGAGGCCGGAGAAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM4903834
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_b
Location of target site NM_024667 | 3UTR | CAGAGGCCGGAGAAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM4903835
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_c
Location of target site NM_024667 | 3UTR | CAGAGGCCGGAGAAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM1065668
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / 4-thiouridine, ML_MM_7
Location of target site ENST00000267202.2 | 3UTR | UUUGCACUGGGCCCACUGCCGAGUCC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
HNSC -0.442 0 -0.408 0 42 Click to see details
KICH -0.479 0.01 -0.431 0.02 25 Click to see details
PRAD 0.323 0.01 0.180 0.11 50 Click to see details
LIHC -0.286 0.02 -0.245 0.04 49 Click to see details
KIRC -0.238 0.03 -0.241 0.02 67 Click to see details
CESC 0.992 0.04 1.000 0.5 3 Click to see details
BLCA 0.36 0.07 0.321 0.1 18 Click to see details
PCPG 0.954 0.1 1.000 0.5 3 Click to see details
BRCA -0.143 0.1 -0.095 0.2 83 Click to see details
KIRP -0.238 0.11 -0.302 0.06 29 Click to see details
LUAD -0.348 0.13 -0.336 0.14 12 Click to see details
LUSC 0.154 0.18 0.205 0.11 38 Click to see details
STAD -0.165 0.18 -0.218 0.12 32 Click to see details
CHOL -0.215 0.29 -0.250 0.26 9 Click to see details
UCEC 0.082 0.37 -0.033 0.45 19 Click to see details
THCA 0.029 0.41 -0.061 0.32 59 Click to see details
ESCA 0.048 0.44 0.109 0.37 11 Click to see details
PAAD 0.033 0.48 0.400 0.3 4 Click to see details
PAAD 0.033 0.48 0.400 0.3 4 Click to see details
32 hsa-miR-378c Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT052829 DDX17 DEAD-box helicase 17 1 1
MIRT052830 RPS7 ribosomal protein S7 1 1
MIRT052831 SEC31A SEC31 homolog A, COPII coat complex component 1 1
MIRT052832 KDM8 lysine demethylase 8 1 1
MIRT052833 ANO4 anoctamin 4 1 1
MIRT463104 ZNF609 zinc finger protein 609 2 2
MIRT469375 REST RE1 silencing transcription factor 2 6
MIRT495444 KCNJ6 potassium voltage-gated channel subfamily J member 6 2 2
MIRT513609 VPS37B VPS37B, ESCRT-I subunit 2 2
MIRT520417 TXNL1 thioredoxin like 1 2 4
MIRT525114 PRKD2 protein kinase D2 2 2
MIRT525982 SPA17 sperm autoantigenic protein 17 2 2
MIRT527005 ARL8B ADP ribosylation factor like GTPase 8B 2 2
MIRT529218 CYP20A1 cytochrome P450 family 20 subfamily A member 1 2 2
MIRT529838 ARGFX arginine-fifty homeobox 2 2
MIRT532302 HAUS3 HAUS augmin like complex subunit 3 2 2
MIRT537579 ESYT2 extended synaptotagmin 2 2 2
MIRT543143 AKT1 AKT serine/threonine kinase 1 2 2
MIRT554927 RAP1B RAP1B, member of RAS oncogene family 2 2
MIRT564973 WTAP WT1 associated protein 2 2
MIRT570119 CACNG8 calcium voltage-gated channel auxiliary subunit gamma 8 2 2
MIRT652737 TGFB2 transforming growth factor beta 2 2 2
MIRT655951 NDST1 N-deacetylase and N-sulfotransferase 1 2 2
MIRT656000 MYRF myelin regulatory factor 2 2
MIRT684878 P4HB prolyl 4-hydroxylase subunit beta 2 2
MIRT692972 LGSN lengsin, lens protein with glutamine synthetase domain 2 2
MIRT693740 ACACA acetyl-CoA carboxylase alpha 2 2
MIRT710994 PPARGC1B PPARG coactivator 1 beta 2 2
MIRT712242 RCC2 regulator of chromosome condensation 2 2 2
MIRT718605 DCTPP1 dCTP pyrophosphatase 1 2 2
MIRT723502 WDR33 WD repeat domain 33 2 2
MIRT725450 HIPK3 homeodomain interacting protein kinase 3 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-378c Tamoxifen 2733525 NSC180973 approved resistant High Breast Cancer cell line (MCF-7, T47D)
hsa-mir-378c Cisplatin 5460033 NSC119875 approved resistant High Gastric Cancer cell line (BGC823)
hsa-miR-378c Fluorouracil 3385 NSC19893 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-miR-378c Gemcitabine 60750 NSC613327 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-miR-378c Gemcitabine 60750 NSC613327 approved resistant High Pancreatic Cancer cell line (SW1990)
hsa-miR-378c Gemcitabine 60750 NSC613327 approved sensitive High Pancreatic Cancer cell line (SW1990)
hsa-miR-378c Cisplatin 5460033 NSC119875 approved resistant High Ovarian Cancer cell line (A2780)
hsa-miR-378c Cisplatin 5460033 NSC119875 approved resistant High Ovarian Cancer cell line (A2780)
hsa-miR-378c Aromatase Inhibitor sensitive Low Breast Cancer cell line (MCF-7)
hsa-miR-378c Imatinib 5291 NSC743414 approved resistant High Chronic Myelogenous Leukemia tissue
hsa-miR-378c Palbociclib 5330286 NSC758247 approved sensitive High Breast Cancer cell line (T47D)
hsa-miR-378c Doxorubicin 31703 NSC123127 approved resistant High Breast Cancer tissue
hsa-miR-378c Paclitaxel 36314 NSC125973 approved resistant High Breast Cancer tissue
hsa-mir-378c Androstenedione 6128 NSC9563 sensitive cell line (MCF-7)
hsa-mir-378c Androstenedione+Anastrozole sensitive cell line (MCF-7)
hsa-mir-378c Tamoxifen 2733525 NSC180973 approved resistant cell line (MCF7)
hsa-mir-378c Cisplatin 5460033 NSC119875 approved resistant cell line (BGC-823)
hsa-miR-378c Temozolomide 5394 NSC362856 approved resistant cell line (U251)
hsa-miR-378c Palbociclib 5330286 NSC758247 approved sensitive tissue (breast cancer)
hsa-miR-378c Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-378c Doxorubicin 31703 NSC123127 approved sensitive cell line (BAS)
hsa-miR-378c Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-378c Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-miR-378c Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-378c Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)
hsa-miR-378c Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-miR-378c Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR4)

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