miRTarBase - #MIRT513870


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pre-miRNA Information
pre-miRNA hsa-mir-4457   
Genomic Coordinates chr5: 1309310 - 1309377
Description Homo sapiens miR-4457 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4457
Sequence 43| UCACAAGGUAUUGACUGGCGUA |64
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1031676297 8 dbSNP
rs1249861366 14 dbSNP
rs115769169 17 dbSNP
rs968846507 19 dbSNP
rs540870271 20 dbSNP
rs993130937 22 dbSNP
Putative Targets

Gene Information
Gene Symbol HOXA5   
Synonyms HOX1, HOX1.3, HOX1C
Description homeobox A5
Transcript NM_019102   
Expression
Putative miRNA Targets on HOXA5
3'UTR of HOXA5
(miRNA target sites are highlighted)		 
>HOXA5|NM_019102|3'UTR
   1 GTATCTGAGCGTTTAAAGTACTGAGCAGTATTAGCGGATCCCGCGTAGTGTCAGTACTAAGGTGACTTTCTGAAACTCCC
  81 TTGTGTTCCTTCTGTGAAGAAGCCCTGTTCTCGTTGCCCTAATTCATCTTTTAATCATGAGCCTGTTTATTGCCATTATA
 161 GCGCCTGTATAAGTAGATCTGCTTTCTGTTCATCTCTTTGTCCTGAATGGCTTTGTCTTGAAAAAAAATAGATGTTTTAA
 241 CTTATTTATATGAAGCAAGCTGTGTTACTTGAAGTAACTATAACAAAAAAAGAAAAGAGAAAAAAAAACACACAAAAAGT
 321 CCCCCTTCAATCTCGTTTAGTGCCAATGTTGTGTGTTGCACTCAAGTTGTTTAACTGTGCATGTGCGTGGAAGTGTTCCT
 401 GTCTCAATAGCTCCAAGCTGTTAAAGATATTTTTATTCAAACTACCTATATTCCTTGTGTAATTAATGCTGTTGTAGAGG
 481 TGACTTGATGAGACACAACTTGTTCGACGTGTAGTGACTAGTGACTCTGTGATGAAAACTGTGACTCCAAGCGGTGTGTC
 561 CCTGCGTGCCTTTATAGGACCCTTTGCACGAACTCTGGAAGTGGCTCTTATAAGCGCAGCTTCAGTGATGTATGTTTTTG
 641 TGAACAAAGTTACAAATATTGTCCAAGTCTGGCTGTTTTAAGCAAACTGTGATCAGCTTTTTTTTTTTTTTTTTTTTTTT
 721 TGTATTTGTTTTTAAGGAAAAAATACTGACTGGAACAAAAAATAAACTTTCTATTGTAAGTTC
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' augcGGUCAGU-UAUGGAACACu 5'
              |:|  :| || ||||||| 
Target 5' caaaCTACCTATATTCCTTGTGt 3'
 438 - 460 150.00 -11.60
2 
miRNA  3' augcGGUCAGUUAUGGAACACu 5'
              :| |  | | ||||||| 
Target 5' acttTCTGAAACTCCCTTGTGt 3'
 65 - 86 146.00 -9.50
3 
miRNA  3' auGCGGUCAGU---UAU-GGAACACu 5'
            | :|||| |   ||: ::||||| 
Target 5' agCTTCAGTGATGTATGTTTTTGTGa 3'
 618 - 643 124.00 -12.10
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN17181822 10 COSMIC
COSN30137820 11 COSMIC
COSN30113191 17 COSMIC
COSN30694478 32 COSMIC
COSN31484642 40 COSMIC
COSN26979192 43 COSMIC
COSN30505617 45 COSMIC
COSN30530267 56 COSMIC
COSN31505570 56 COSMIC
COSN31562488 77 COSMIC
COSN26670735 106 COSMIC
COSN30156635 110 COSMIC
COSN30138266 129 COSMIC
COSN30148318 131 COSMIC
COSN30171080 145 COSMIC
COSN31575694 162 COSMIC
COSN28250115 183 COSMIC
COSN31488183 191 COSMIC
COSN31567024 211 COSMIC
COSN30174267 220 COSMIC
COSN8516347 269 COSMIC
COSN31589095 284 COSMIC
COSN20103996 299 COSMIC
COSN31517911 299 COSMIC
COSN26645238 309 COSMIC
COSN28250035 326 COSMIC
COSN28249890 331 COSMIC
COSN28250221 375 COSMIC
COSN6877149 387 COSMIC
COSN19129998 400 COSMIC
COSN7976343 517 COSMIC
COSN7976342 653 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1291982091 1 dbSNP
rs17472021 2 dbSNP
rs746464061 3 dbSNP
rs1224689844 6 dbSNP
rs1297855147 7 dbSNP
rs1436920804 8 dbSNP
rs544222737 11 dbSNP
rs1372868230 15 dbSNP
rs17472014 17 dbSNP
rs765056005 18 dbSNP
rs898140225 21 dbSNP
rs754744687 23 dbSNP
rs1404095484 25 dbSNP
rs754079768 30 dbSNP
rs200683571 35 dbSNP
rs1001305429 36 dbSNP
rs1047290 38 dbSNP
rs1170882007 39 dbSNP
rs1325345091 42 dbSNP
rs1340814126 43 dbSNP
rs555485879 45 dbSNP
rs535561992 46 dbSNP
rs1247665826 47 dbSNP
rs572966051 48 dbSNP
rs1001169296 51 dbSNP
rs907457854 53 dbSNP
rs1341409077 55 dbSNP
rs1218645187 58 dbSNP
rs1046046099 60 dbSNP
rs1459664648 61 dbSNP
rs1205147036 63 dbSNP
rs73290303 81 dbSNP
rs1434637296 84 dbSNP
rs945832269 89 dbSNP
rs1375227262 96 dbSNP
rs1478436702 102 dbSNP
rs913189013 107 dbSNP
rs1393073470 112 dbSNP
rs1054773560 113 dbSNP
rs936714820 118 dbSNP
rs1173374353 121 dbSNP
rs1384597869 134 dbSNP
rs868722960 136 dbSNP
rs1381385538 141 dbSNP
rs975355610 145 dbSNP
rs964103613 153 dbSNP
rs1454044696 161 dbSNP
rs1400563578 162 dbSNP
rs912606934 163 dbSNP
rs1320755152 168 dbSNP
rs1224886211 169 dbSNP
rs1210597132 170 dbSNP
rs911271565 173 dbSNP
rs1203689148 176 dbSNP
rs527398886 177 dbSNP
rs768855343 181 dbSNP
rs987024770 184 dbSNP
rs1484942119 190 dbSNP
rs1260603735 193 dbSNP
rs539680091 200 dbSNP
rs951621246 202 dbSNP
rs1025921941 203 dbSNP
rs1481452235 206 dbSNP
rs747208206 208 dbSNP
rs762390514 217 dbSNP
rs879077665 221 dbSNP
rs1451941818 227 dbSNP
rs1156546768 229 dbSNP
rs139068122 229 dbSNP
rs1420117612 234 dbSNP
rs1302462828 248 dbSNP
rs1034032543 256 dbSNP
rs183022466 263 dbSNP
rs1343623037 266 dbSNP
rs1387941968 274 dbSNP
rs1047294 292 dbSNP
rs1001169495 294 dbSNP
rs1334763269 296 dbSNP
rs201939031 299 dbSNP
rs869235274 299 dbSNP
rs967303762 299 dbSNP
rs397733321 300 dbSNP
rs1354864665 301 dbSNP
rs1011381505 308 dbSNP
rs1290148406 309 dbSNP
rs397700719 309 dbSNP
rs5883063 309 dbSNP
rs1184209636 310 dbSNP
rs1301761924 310 dbSNP
rs906955696 310 dbSNP
rs1045507426 313 dbSNP
rs1440057136 315 dbSNP
rs957118850 315 dbSNP
rs1299364298 326 dbSNP
rs1363565723 329 dbSNP
rs1459407666 334 dbSNP
rs1034063332 335 dbSNP
rs1293552358 335 dbSNP
rs1010106055 358 dbSNP
rs891611395 359 dbSNP
rs906894858 361 dbSNP
rs78899540 362 dbSNP
rs1222924315 363 dbSNP
rs1303318106 368 dbSNP
rs935929440 370 dbSNP
rs1479694668 372 dbSNP
rs1467558194 373 dbSNP
rs921817399 375 dbSNP
rs879284946 379 dbSNP
rs562682994 382 dbSNP
rs1390957672 384 dbSNP
rs537028257 385 dbSNP
rs1038950795 386 dbSNP
rs1426774646 387 dbSNP
rs1261182023 391 dbSNP
rs1459975382 397 dbSNP
rs568152628 398 dbSNP
rs1400523136 399 dbSNP
rs1451495006 402 dbSNP
rs889949527 405 dbSNP
rs548247202 410 dbSNP
rs1210525034 418 dbSNP
rs1381760801 419 dbSNP
rs1049835884 444 dbSNP
rs528578706 449 dbSNP
rs191986702 459 dbSNP
rs186277638 460 dbSNP
rs918766656 465 dbSNP
rs1220472859 471 dbSNP
rs1258831431 472 dbSNP
rs978096079 478 dbSNP
rs974241761 480 dbSNP
rs1325318815 483 dbSNP
rs1312866650 492 dbSNP
rs1397711067 505 dbSNP
rs962965765 508 dbSNP
rs1312213336 509 dbSNP
rs370019658 511 dbSNP
rs1372217038 520 dbSNP
rs745981430 521 dbSNP
rs913115587 525 dbSNP
rs556367512 526 dbSNP
rs1460706308 527 dbSNP
rs778968803 529 dbSNP
rs1034169653 532 dbSNP
rs1165651619 538 dbSNP
rs1449134137 541 dbSNP
rs1476228832 541 dbSNP
rs1288656457 543 dbSNP
rs1255950097 552 dbSNP
rs979869662 553 dbSNP
rs1187888124 555 dbSNP
rs879066570 556 dbSNP
rs1322870800 561 dbSNP
rs1221832145 562 dbSNP
rs1280931638 563 dbSNP
rs1313004104 566 dbSNP
rs1210510837 575 dbSNP
rs971111313 577 dbSNP
rs764234150 579 dbSNP
rs1195720562 580 dbSNP
rs1158410216 581 dbSNP
rs1024402935 582 dbSNP
rs1479815154 583 dbSNP
rs757278188 586 dbSNP
rs1253154041 590 dbSNP
rs1414710819 609 dbSNP
rs1193692952 611 dbSNP
rs183316972 616 dbSNP
rs971045228 629 dbSNP
rs1265669583 634 dbSNP
rs544159974 634 dbSNP
rs1421945173 649 dbSNP
rs1299338762 654 dbSNP
rs1345451515 658 dbSNP
rs1024088562 661 dbSNP
rs1403113122 663 dbSNP
rs1276720900 667 dbSNP
rs1223413917 669 dbSNP
rs763001791 672 dbSNP
rs1332060344 673 dbSNP
rs897401933 675 dbSNP
rs1286575504 683 dbSNP
rs1490166751 691 dbSNP
rs1228977493 692 dbSNP
rs1352075808 695 dbSNP
rs1326676226 696 dbSNP
rs1389883564 697 dbSNP
rs1395954385 698 dbSNP
rs1015287468 699 dbSNP
rs1294352570 702 dbSNP
rs200652151 704 dbSNP
rs1247968960 709 dbSNP
rs1415809828 710 dbSNP
rs1164796557 718 dbSNP
rs1473232492 719 dbSNP
rs1159634732 722 dbSNP
rs1176237503 722 dbSNP
rs1277993286 722 dbSNP
rs1309747601 722 dbSNP
rs1326172499 722 dbSNP
rs1350514635 722 dbSNP
rs1358576988 722 dbSNP
rs1365465243 722 dbSNP
rs1405424116 722 dbSNP
rs1423318500 722 dbSNP
rs1441657825 722 dbSNP
rs1441914687 722 dbSNP
rs1458839680 722 dbSNP
rs147485948 722 dbSNP
rs529614939 722 dbSNP
rs548741419 722 dbSNP
rs747465393 722 dbSNP
rs751650371 722 dbSNP
rs76984887 722 dbSNP
rs777876701 722 dbSNP
rs796119125 722 dbSNP
rs879161679 722 dbSNP
rs1365898130 723 dbSNP
rs6461989 723 dbSNP
rs1009957315 724 dbSNP
rs143765190 725 dbSNP
rs17449164 725 dbSNP
rs1415232790 726 dbSNP
rs17449157 727 dbSNP
rs1409395535 728 dbSNP
rs895626867 728 dbSNP
rs1437627943 729 dbSNP
rs1402673794 730 dbSNP
rs17449150 731 dbSNP
rs1267552941 734 dbSNP
rs1215210142 735 dbSNP
rs1336374558 735 dbSNP
rs1381729036 736 dbSNP
rs1466729019 736 dbSNP
rs1272048559 744 dbSNP
rs1209266118 745 dbSNP
rs1017225914 753 dbSNP
rs1213436888 774 dbSNP
rs891521094 776 dbSNP
rs1352837180 778 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 3202.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM1065668. RNA binding protein: AGO1. Condition:4-thiouridine ...

- Memczak S; Jens M; Elefsinioti A; Torti F; et al., 2013, Nature.

Article - Memczak S; Jens M; Elefsinioti A; Torti F; et al.
- Nature, 2013
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.
LinkOut: [PMID: 23446348]
CLIP-seq Support 1 for dataset GSM1065668
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / 4-thiouridine, ML_MM_7
Location of target site ENST00000222726.3 | 3UTR | AUAUUUUUAUUCAAACUACCUAUAUUC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
83 hsa-miR-4457 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT098032 SOBP sine oculis binding protein homolog 2 2
MIRT202580 PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 2 6
MIRT247137 WEE1 WEE1 G2 checkpoint kinase 2 4
MIRT349266 PTBP1 polypyrimidine tract binding protein 1 2 2
MIRT363756 EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 2 2
MIRT443586 FAM84B family with sequence similarity 84 member B 2 2
MIRT452333 EIF5AL1 eukaryotic translation initiation factor 5A-like 1 2 2
MIRT453864 ZBTB40 zinc finger and BTB domain containing 40 2 4
MIRT471486 PDE4D phosphodiesterase 4D 2 4
MIRT476290 GMFB glia maturation factor beta 2 8
MIRT479897 CCDC117 coiled-coil domain containing 117 2 4
MIRT484251 ANK1 ankyrin 1 2 2
MIRT491473 TMEM214 transmembrane protein 214 2 2
MIRT493804 GAN gigaxonin 2 6
MIRT499252 VAV3 vav guanine nucleotide exchange factor 3 2 4
MIRT502271 HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 2 4
MIRT504651 RPL9 ribosomal protein L9 2 6
MIRT505211 UBN2 ubinuclein 2 2 8
MIRT508952 SNRPB small nuclear ribonucleoprotein polypeptides B and B1 2 4
MIRT512691 POP1 POP1 homolog, ribonuclease P/MRP subunit 2 2
MIRT513320 SCUBE3 signal peptide, CUB domain and EGF like domain containing 3 2 2
MIRT513870 HOXA5 homeobox A5 2 2
MIRT517342 ZNF529 zinc finger protein 529 2 4
MIRT518947 LSG1 large 60S subunit nuclear export GTPase 1 2 2
MIRT520867 SUGT1 SGT1 homolog, MIS12 kinetochore complex assembly cochaperone 2 2
MIRT528325 GIGYF2 GRB10 interacting GYF protein 2 2 2
MIRT531990 SLCO1B3 solute carrier organic anion transporter family member 1B3 2 2
MIRT533298 USP46 ubiquitin specific peptidase 46 2 2
MIRT545257 TRIM36 tripartite motif containing 36 2 4
MIRT547038 POGZ pogo transposable element derived with ZNF domain 2 2
MIRT556103 MOAP1 modulator of apoptosis 1 2 2
MIRT558321 DR1 down-regulator of transcription 1 2 2
MIRT558521 CSRNP3 cysteine and serine rich nuclear protein 3 2 2
MIRT560906 TMED10 transmembrane p24 trafficking protein 10 2 2
MIRT568448 ARPP19 cAMP regulated phosphoprotein 19 2 2
MIRT570586 OTUD7B OTU deubiquitinase 7B 2 2
MIRT572799 SIGLEC14 sialic acid binding Ig like lectin 14 2 2
MIRT573863 C9orf78 chromosome 9 open reading frame 78 2 2
MIRT575058 P2ry1 purinergic receptor P2Y, G-protein coupled 1 2 5
MIRT609931 SLC38A1 solute carrier family 38 member 1 2 4
MIRT610836 ZNF585A zinc finger protein 585A 2 4
MIRT611474 P2RY1 purinergic receptor P2Y1 2 7
MIRT613569 YY2 YY2 transcription factor 2 2
MIRT618626 GREB1 growth regulation by estrogen in breast cancer 1 2 2
MIRT620606 SAP30 Sin3A associated protein 30 2 2
MIRT621017 CLSTN3 calsyntenin 3 2 4
MIRT635314 FAM179A TOG array regulator of axonemal microtubules 2 2 2
MIRT635919 GLTSCR2 NOP53 ribosome biogenesis factor 2 2
MIRT640598 TM9SF4 transmembrane 9 superfamily member 4 2 2
MIRT641784 YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta 2 4
MIRT644067 IQCE IQ motif containing E 2 2
MIRT648288 TRAPPC2L trafficking protein particle complex 2 like 2 2
MIRT658085 FOXR2 forkhead box R2 2 2
MIRT659077 DEPTOR DEP domain containing MTOR interacting protein 2 2
MIRT665307 ZBTB37 zinc finger and BTB domain containing 37 2 2
MIRT665975 SYTL4 synaptotagmin like 4 2 2
MIRT666302 SLC25A25 solute carrier family 25 member 25 2 2
MIRT674906 RASSF9 Ras association domain family member 9 2 2
MIRT680086 THAP1 THAP domain containing 1 2 2
MIRT681488 DIP2A disco interacting protein 2 homolog A 2 2
MIRT691244 DFNB59 pejvakin 2 2
MIRT692362 AGTRAP angiotensin II receptor associated protein 2 2
MIRT693035 MB21D1 Mab-21 domain containing 1 2 2
MIRT693837 STAT5A signal transducer and activator of transcription 5A 2 2
MIRT694479 LRTOMT leucine rich transmembrane and O-methyltransferase domain containing 2 2
MIRT696070 ZNF264 zinc finger protein 264 2 2
MIRT696578 TTC21B tetratricopeptide repeat domain 21B 2 2
MIRT696760 MTFMT mitochondrial methionyl-tRNA formyltransferase 2 2
MIRT697307 ZNF652 zinc finger protein 652 2 2
MIRT700152 RNF115 ring finger protein 115 2 2
MIRT701056 PARP2 poly(ADP-ribose) polymerase 2 2 2
MIRT701198 OTUD3 OTU deubiquitinase 3 2 2
MIRT701335 NSD1 nuclear receptor binding SET domain protein 1 2 2
MIRT702656 ITGA3 integrin subunit alpha 3 2 2
MIRT703618 FBXO45 F-box protein 45 2 2
MIRT704673 CHTOP chromatin target of PRMT1 2 2
MIRT708894 ZNF780A zinc finger protein 780A 2 2
MIRT711620 DGKH diacylglycerol kinase eta 2 2
MIRT713745 TMEM81 transmembrane protein 81 2 2
MIRT719712 CD101 CD101 molecule 2 2
MIRT720294 DLGAP3 DLG associated protein 3 2 2
MIRT722606 CCDC152 coiled-coil domain containing 152 2 2
MIRT724566 ACSBG1 acyl-CoA synthetase bubblegum family member 1 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4457 Dabrafenib 44462760 NSC764134 approved sensitive cell line (A375)
hsa-miR-4457 Gefitinib 123631 NSC715055 approved sensitive cell line (PC9)
hsa-miR-4457 Osimertinib 71496458 NSC779217 approved sensitive cell line (PC9)
hsa-miR-4457 Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)

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