miRTarBase - #MIRT514429


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pre-miRNA Information
pre-miRNA hsa-mir-19a   
Genomic Coordinates chr13: 91350891 - 91350972
Synonyms MIRN19A, hsa-mir-19a, miR-19a, miRNA19A, MIR19A
Description Homo sapiens miR-19a stem-loop
Comment This sequence maps to chromosome 13 and is named miR-19a precursor-13 in reference .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-19a-5p
Sequence 14| AGUUUUGCAUAGUUGCACUACA |35
Evidence Experimental
Experiments Cloned
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs756288295 2 dbSNP
rs1051963210 6 dbSNP
rs780315531 8 dbSNP
rs1162564162 9 dbSNP
rs1170543143 13 dbSNP
rs1388542964 15 dbSNP
rs1442807536 18 dbSNP
rs1403138754 20 dbSNP
rs764765453 21 dbSNP
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Biomarker Information
Biomarker ID Name Type Discovered From Mode Level Source Testing Methods
BST0O9 miR-19a Predictive Biomarker (PRD) Clinical/Experimental Data Expression Decrease Tumor tissue Quantitative real-time PCR
Gene Information
Gene Symbol SLC38A7   
Synonyms SNAT7
Description solute carrier family 38 member 7
Transcript NM_018231   
Expression
Putative miRNA Targets on SLC38A7
3'UTR of SLC38A7
(miRNA target sites are highlighted)		 
>SLC38A7|NM_018231|3'UTR
   1 CCACTGCCTCCCAGGGAACACAAGGCCTTTGCCATTGGTCGCAGGAACCCATCTCTTAGAGCTATGGGGCCATTCTTAGT
  81 CCACGATCATTCCAACTGGTGGGATGACATCCGGACATCCTCTTCCAGGGACTGGGGCAAACTCAGGCCCCACACCTCTG
 161 GACAGCTCAAATCCAGTCCCCTTCCTGCTCCCCAGTCCTGGCAGTGCCGTGGATGGCGGCAGGAAGTCTCACATCATAGA
 241 GGACCCCTCCTCCTCTCCCAGTTCTCAACTTCTCCATGCCTGGAATCCACGGGTGAAGAGAGTCGGTAGATCTCATAAGA
 321 AAGAATCCAGTCTGACTTCCCTCTGGAGAATGACTATGGACAGAAGGCCACCATCCTCCACAGAGCACCCTGTCCTGAGT
 401 AGGGGTTGTGCTCATTACCCCAGGCCAGTGGTAGCTTCCTCAGGAGCCTGGCCACTTCCAACGGTAGCACTGAAGTCATG
 481 CAAATGCATAGTCAGGTAGATTCAGACCTTGTCCACACCTTCCTGGGCAACCCCCACCATGAACCTGTCAGCCTCTTTCC
 561 CATAGCTAATAGACATTTCCCAGGCCTTGAGGGGCCCCACCCTGTCTCTTTCATCAAACCTGATGGTCCAGGCTGGGCAT
 641 CCCTCTCCTCCTCCATCCCCAGACATCACCAGGTCTAATGTTTACAAACGGTGCCAGCCCGGCTCTGAAGCCAAGGGCCG
 721 TCCCGTGCCACGGTGCTGTGAGTATTCCTCCGTTAGCTTTCCCCATAAGGTTGGGAGTATCTGCTTTTGTGTCTGAGATG
 801 GGCCCCTCTTTTCAGAGGCCGCAGGGTGGGTGATGGAGAAGGCTGAGAACCTTTCAGACCCTCTGTGTGGGCTGGGCTGG
 881 TCAGAATCAGGGTGTACCTCCCCGACACCTTCTTTTTCAGTGATGTTTTCTCTTCTTCCTGCCTTTCCTCTGCCTCCTCC
 961 CCTGCCAGCCCTAGCGTGACTACCCAGAGACAAAAAAAAAAAAAAAAAAAAAAGGCAGGGCTGGGCGCAGTGGCTCACGC
1041 CTGTAATCCCAGCACTTTGGGAGGCCAAGGCGGGCAGATGACTTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACACGG
1121 CAAAACCCCATCTCTACTAAAAATACAAAAAATTAACCGGGCATGGTGGCGGGCACCTGTAATCCCAGCTACTTGGGAGG
1201 CTGAGGCAGCAGAGCCGCTTAAACCCAGGAGGCAGAGACTGCAATGAGCTGAGATCGTGCCATTGCACTCCAGCTTGGGC
1281 AACAAGAGTGAAACTTCATCTCAAAAAAACAGAAACAAACAAAAAGGCAGCTGGGTTGTCACTGATGGGCAGCATTTGAG
1361 CCTGCCACACTGGCCTGGAAGTTTCCCTTCCAGTCTGGATTTTGTCTGCTCCTTCCTTCCCCCTCACCCCGTTACCTCTT
1441 CACCTCCCATCTCACTTCACTGTGTAGCTCAGTCTCTCCCACGCACATAATTGGGGACAGTGGGGGCTCTCTTACCAGCC
1521 TCCTCAGCAACGCACGTCCATCAGGCCTGGCCTCAGTGGCCAGCCACATTGATGTCACACTGGAATTGTTACCCCAGAGA
1601 GGGCGAAGAGATAGGCTATCTCCCCACCTCCCACCCTACTCCCCACTATATTCCCGTTTTGACCACCTCAGCCCCTCAGC
1681 TGCCCCCTCTCACTTTGGCCAATCCCAGGCACCAATCAGACTTCCTCCTCCACCTGGAGCCCCTAGCATTTCCTTGTCCC
1761 CTCTTCCCCAAAACCTCTGTAAAGGGTACGAGAGGGACCCCCTGCCGAGCCGCCCGCCACTCAGGGCAGTCCGATCTAAG
1841 AAGCAGAAGCTGGTTGGAGGCTGGCTGGGCCTCTGTCCAGTCCCCAGATGGATAAACTGCCTTTTCTCACATCCCCTCTT
1921 GGTGCCTGATCTTCTCTGCCCCCGGGGCCAGACCCACTGTGCTGTTTTCTGTCAGTCTGTGGCACAGCACCAAGCTCTGC
2001 CAGCACCAGTCCCTGACAGGGCTAGGAGGACAGCCTGGTCAGCAGGGCTGCAGTCCCCCAGTGCCGTGTTTCGGGGGTCA
2081 AGGGATGTAAGTGGAGTCATTGCACAGAGACAGACCAGTCAGGAGAAGGAGCTGGAATCTGGCCTCTTGTCCTAACCTCA
2161 GGAGCCCCCTCCCATCCTCTCCCCACCCTCCCTATCGGGGTACTTCACTGTTTCTTTTCTACTTGTGTATACTCGAGAAA
2241 GGGAAGATGGTTAATAAAAGGGATTTGTGCTGCTGA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' acaucacGUUGAUACGUUUUGa 5'
                 ||||   ||||||| 
Target 5' gcctggcCAACACGGCAAAACc 3'
 1106 - 1127 151.00 -9.90
2 
miRNA  3' acAUCACGUUGAU-ACGUUUUGa 5'
            | | ||||| |  |::|||| 
Target 5' gcTTGGGCAACAAGAGTGAAACt 3'
 1273 - 1295 128.00 -8.50
3 
miRNA  3' acAUC---ACGUUGAUACGUUUuga 5'
            |||   || |:: |||||||   
Target 5' ggTAGCACTGAAGTCATGCAAAtgc 3'
 463 - 487 124.00 -9.60
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30475098 10 COSMIC
COSN30728535 14 COSMIC
COSN19750659 23 COSMIC
COSN24872557 34 COSMIC
COSN30496339 40 COSMIC
COSN31541964 44 COSMIC
COSN26635082 62 COSMIC
COSN31517219 75 COSMIC
COSN30152449 76 COSMIC
COSN30530161 84 COSMIC
COSN30165813 99 COSMIC
COSN30533421 113 COSMIC
COSN31520050 656 COSMIC
COSN29116067 720 COSMIC
COSN31562018 767 COSMIC
COSN31551208 781 COSMIC
COSN6087872 1035 COSMIC
COSN6087871 1042 COSMIC
COSN6087870 1083 COSMIC
COSN8234262 1345 COSMIC
COSN7262210 1351 COSMIC
COSN32065550 1597 COSMIC
COSN32065235 1605 COSMIC
COSN21502771 1734 COSMIC
COSN17491074 1797 COSMIC
COSN19741440 1812 COSMIC
COSN1188520 1856 COSMIC
COSN32064357 1882 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1291367753 2 dbSNP
rs757387507 5 dbSNP
rs1422749811 8 dbSNP
rs1046183241 12 dbSNP
rs747105214 14 dbSNP
rs1460460098 18 dbSNP
rs777648494 19 dbSNP
rs1422767896 24 dbSNP
rs1194337966 25 dbSNP
rs1400781928 30 dbSNP
rs369506296 31 dbSNP
rs1448638567 34 dbSNP
rs1265017866 40 dbSNP
rs377338753 41 dbSNP
rs1488926330 45 dbSNP
rs1404280413 49 dbSNP
rs918961779 51 dbSNP
rs1378662485 58 dbSNP
rs1396805141 61 dbSNP
rs916275983 64 dbSNP
rs1196803711 66 dbSNP
rs372988602 68 dbSNP
rs779432472 69 dbSNP
rs539052273 70 dbSNP
rs765680985 71 dbSNP
rs1221013492 74 dbSNP
rs755361903 75 dbSNP
rs189625164 79 dbSNP
rs766114265 82 dbSNP
rs755459159 84 dbSNP
rs1327522985 85 dbSNP
rs1463566606 89 dbSNP
rs746566255 95 dbSNP
rs772849383 95 dbSNP
rs369443312 97 dbSNP
rs12447480 100 dbSNP
rs779741765 101 dbSNP
rs774128053 112 dbSNP
rs768565238 113 dbSNP
rs749071649 114 dbSNP
rs907667781 119 dbSNP
rs775209639 124 dbSNP
rs1457323994 126 dbSNP
rs754195568 128 dbSNP
rs1171049106 147 dbSNP
rs150400130 149 dbSNP
rs941965850 153 dbSNP
rs954608223 156 dbSNP
rs1426160255 164 dbSNP
rs1030154919 173 dbSNP
rs1192864576 177 dbSNP
rs910489632 179 dbSNP
rs568540637 180 dbSNP
rs766851321 184 dbSNP
rs1467015708 187 dbSNP
rs77543879 188 dbSNP
rs954575451 194 dbSNP
rs1466804288 198 dbSNP
rs558720388 201 dbSNP
rs976843946 208 dbSNP
rs377144499 209 dbSNP
rs1279412270 210 dbSNP
rs1011132029 214 dbSNP
rs894069477 217 dbSNP
rs1020937730 218 dbSNP
rs1276621172 221 dbSNP
rs1031128783 230 dbSNP
rs1210401648 232 dbSNP
rs1000099399 233 dbSNP
rs1484625705 236 dbSNP
rs906736538 243 dbSNP
rs1306916387 244 dbSNP
rs1010886259 245 dbSNP
rs372283137 247 dbSNP
rs1424277673 250 dbSNP
rs1388350481 252 dbSNP
rs1433498621 255 dbSNP
rs947825028 263 dbSNP
rs1343602213 264 dbSNP
rs1419301085 267 dbSNP
rs1302170955 268 dbSNP
rs894786428 287 dbSNP
rs1037338486 291 dbSNP
rs1403699622 293 dbSNP
rs1002831268 294 dbSNP
rs748508714 297 dbSNP
rs941914720 298 dbSNP
rs906741326 302 dbSNP
rs1302985971 303 dbSNP
rs907782573 304 dbSNP
rs1238935296 308 dbSNP
rs1286198846 308 dbSNP
rs1046595125 309 dbSNP
rs993275445 310 dbSNP
rs983423725 315 dbSNP
rs1192751782 321 dbSNP
rs761186846 322 dbSNP
rs1439391388 323 dbSNP
rs1159459283 341 dbSNP
rs113411129 342 dbSNP
rs571133332 348 dbSNP
rs1462930598 361 dbSNP
rs1373054242 362 dbSNP
rs143050050 367 dbSNP
rs1435313991 380 dbSNP
rs1350928754 390 dbSNP
rs115724372 397 dbSNP
rs964135080 398 dbSNP
rs1018252861 404 dbSNP
rs563737581 405 dbSNP
rs1445663346 407 dbSNP
rs1489861842 412 dbSNP
rs1050366749 413 dbSNP
rs750659058 418 dbSNP
rs1206033810 423 dbSNP
rs1226067480 430 dbSNP
rs1355237687 430 dbSNP
rs933235845 434 dbSNP
rs767681829 438 dbSNP
rs548683361 439 dbSNP
rs530243929 447 dbSNP
rs561727801 454 dbSNP
rs879206479 461 dbSNP
rs4784965 462 dbSNP
rs11860249 475 dbSNP
rs1457108366 478 dbSNP
rs4784964 486 dbSNP
rs1240217446 487 dbSNP
rs1442882142 491 dbSNP
rs1282169817 496 dbSNP
rs1414588588 498 dbSNP
rs1407640829 503 dbSNP
rs1168942693 504 dbSNP
rs914004299 518 dbSNP
rs989941430 524 dbSNP
rs1331658821 526 dbSNP
rs1378715496 530 dbSNP
rs867165164 531 dbSNP
rs958069284 533 dbSNP
rs1379246650 540 dbSNP
rs1221297826 547 dbSNP
rs1229971842 550 dbSNP
rs1025112160 559 dbSNP
rs1034096295 560 dbSNP
rs1011918638 575 dbSNP
rs894902542 576 dbSNP
rs112428565 593 dbSNP
rs185606330 596 dbSNP
rs1396360934 599 dbSNP
rs886136683 601 dbSNP
rs1238186672 628 dbSNP
rs1048090338 633 dbSNP
rs1473787012 649 dbSNP
rs933268201 651 dbSNP
rs1016024231 655 dbSNP
rs1173322494 657 dbSNP
rs1006344363 659 dbSNP
rs1412456445 679 dbSNP
rs888825771 683 dbSNP
rs762805484 687 dbSNP
rs754336462 689 dbSNP
rs1449530139 695 dbSNP
rs1276251501 698 dbSNP
rs1339817742 700 dbSNP
rs1176244625 701 dbSNP
rs1479571585 710 dbSNP
rs1050506349 714 dbSNP
rs933268331 719 dbSNP
rs775473918 720 dbSNP
rs1214484207 721 dbSNP
rs942721284 724 dbSNP
rs369531179 725 dbSNP
rs914354746 727 dbSNP
rs780772844 731 dbSNP
rs769567085 732 dbSNP
rs989597847 733 dbSNP
rs958265696 735 dbSNP
rs936746128 739 dbSNP
rs1171668935 744 dbSNP
rs1425374238 747 dbSNP
rs1415800122 748 dbSNP
rs1295856780 751 dbSNP
rs181246914 752 dbSNP
rs554758755 752 dbSNP
rs375066153 756 dbSNP
rs1025245236 758 dbSNP
rs368669763 761 dbSNP
rs538230050 761 dbSNP
rs574880588 763 dbSNP
rs971011647 764 dbSNP
rs1016840486 773 dbSNP
rs1025059695 774 dbSNP
rs1288619099 775 dbSNP
rs763635054 779 dbSNP
rs1006003861 782 dbSNP
rs1012368519 787 dbSNP
rs888849063 792 dbSNP
rs1488623142 800 dbSNP
rs1028678997 802 dbSNP
rs745714228 805 dbSNP
rs1333494484 806 dbSNP
rs1451413679 807 dbSNP
rs1305413793 815 dbSNP
rs1379704405 820 dbSNP
rs556568729 821 dbSNP
rs80310996 822 dbSNP
rs1041622216 823 dbSNP
rs1419707459 826 dbSNP
rs780795665 827 dbSNP
rs1388430828 832 dbSNP
rs117468659 834 dbSNP
rs997807357 836 dbSNP
rs796923927 837 dbSNP
rs1444852155 838 dbSNP
rs893005360 841 dbSNP
rs1054685352 843 dbSNP
rs770517500 844 dbSNP
rs1242343571 855 dbSNP
rs1263735055 874 dbSNP
rs1356312912 876 dbSNP
rs936796435 891 dbSNP
rs1269990971 894 dbSNP
rs1039007285 903 dbSNP
rs367779520 904 dbSNP
rs8074 912 dbSNP
rs1237153455 915 dbSNP
rs535222500 924 dbSNP
rs12696 937 dbSNP
rs1362130765 942 dbSNP
rs1189775334 946 dbSNP
rs917885961 954 dbSNP
rs1163707843 955 dbSNP
rs1396411931 958 dbSNP
rs552917958 962 dbSNP
rs371660051 963 dbSNP
rs1242494819 975 dbSNP
rs1181478374 976 dbSNP
rs1466107003 985 dbSNP
rs1284452286 987 dbSNP
rs1204194206 989 dbSNP
rs1348187065 991 dbSNP
rs1266685958 992 dbSNP
rs1244945934 993 dbSNP
rs1246183846 993 dbSNP
rs1384146375 1004 dbSNP
rs1315007483 1005 dbSNP
rs936788303 1005 dbSNP
rs1450834062 1006 dbSNP
rs1367798079 1008 dbSNP
rs1319469883 1009 dbSNP
rs1381849111 1011 dbSNP
rs1198357400 1013 dbSNP
rs1178560374 1014 dbSNP
rs1188197753 1014 dbSNP
rs1253477545 1014 dbSNP
rs1260827322 1014 dbSNP
rs1396642723 1014 dbSNP
rs1400755232 1014 dbSNP
rs1419879436 1014 dbSNP
rs1422657696 1014 dbSNP
rs1457968085 1014 dbSNP
rs1476787481 1014 dbSNP
rs5817157 1014 dbSNP
rs760656023 1014 dbSNP
rs760872724 1014 dbSNP
rs869165322 1014 dbSNP
rs923904081 1014 dbSNP
rs1295682956 1020 dbSNP
rs1383133854 1021 dbSNP
rs1218533899 1022 dbSNP
rs1165040905 1026 dbSNP
rs1425413932 1027 dbSNP
rs188426281 1036 dbSNP
rs971175639 1038 dbSNP
rs918162181 1039 dbSNP
rs991062272 1055 dbSNP
rs1200583711 1067 dbSNP
rs570041893 1071 dbSNP
rs139125379 1072 dbSNP
rs1444902163 1080 dbSNP
rs764946803 1090 dbSNP
rs1006352754 1096 dbSNP
rs950501525 1098 dbSNP
rs1486982655 1099 dbSNP
rs184332916 1099 dbSNP
rs181628771 1107 dbSNP
rs146582259 1118 dbSNP
rs1038955111 1129 dbSNP
rs1217781490 1146 dbSNP
rs1029170147 1153 dbSNP
rs1300990767 1153 dbSNP
rs1271113666 1158 dbSNP
rs1227200787 1159 dbSNP
rs1007504261 1161 dbSNP
rs528306751 1163 dbSNP
rs375374917 1169 dbSNP
rs1263763392 1170 dbSNP
rs545672490 1171 dbSNP
rs1189305227 1184 dbSNP
rs1266379113 1185 dbSNP
rs754390078 1187 dbSNP
rs1175693328 1192 dbSNP
rs1378551005 1198 dbSNP
rs1419125879 1199 dbSNP
rs1042902440 1202 dbSNP
rs1159806118 1206 dbSNP
rs949401290 1212 dbSNP
rs917942354 1216 dbSNP
rs141305870 1217 dbSNP
rs959630369 1221 dbSNP
rs1293377022 1224 dbSNP
rs756524391 1227 dbSNP
rs1420199772 1232 dbSNP
rs1368731770 1239 dbSNP
rs1441197606 1256 dbSNP
rs138834186 1257 dbSNP
rs984976914 1262 dbSNP
rs1350907225 1279 dbSNP
rs541435031 1304 dbSNP
rs377552541 1312 dbSNP
rs1378954545 1314 dbSNP
rs1199701605 1324 dbSNP
rs1490103112 1326 dbSNP
rs1219281948 1333 dbSNP
rs1264704589 1344 dbSNP
rs1266133893 1346 dbSNP
rs553053440 1351 dbSNP
rs1439291219 1353 dbSNP
rs1206741644 1358 dbSNP
rs1410243759 1359 dbSNP
rs143164384 1361 dbSNP
rs1164620466 1370 dbSNP
rs1350839304 1376 dbSNP
rs1463308076 1378 dbSNP
rs905663706 1385 dbSNP
rs976267040 1389 dbSNP
rs750857280 1394 dbSNP
rs1017300052 1399 dbSNP
rs1274355625 1406 dbSNP
rs577352211 1423 dbSNP
rs893060744 1430 dbSNP
rs149110206 1431 dbSNP
rs917956561 1434 dbSNP
rs998690209 1441 dbSNP
rs1335258225 1447 dbSNP
rs1215383454 1453 dbSNP
rs154470 1455 dbSNP
rs940976465 1456 dbSNP
rs909471530 1472 dbSNP
rs1234685927 1474 dbSNP
rs570400115 1482 dbSNP
rs1281434826 1483 dbSNP
rs190539603 1491 dbSNP
rs1444508244 1495 dbSNP
rs1354999175 1497 dbSNP
rs1400025422 1501 dbSNP
rs185608212 1501 dbSNP
rs1329051790 1506 dbSNP
rs1407948325 1515 dbSNP
rs1404078876 1518 dbSNP
rs1055058861 1525 dbSNP
rs566009397 1528 dbSNP
rs975839820 1530 dbSNP
rs938228803 1531 dbSNP
rs909465928 1532 dbSNP
rs985481166 1535 dbSNP
rs547855758 1536 dbSNP
rs375015831 1556 dbSNP
rs1209570224 1572 dbSNP
rs1258282206 1580 dbSNP
rs1019933674 1584 dbSNP
rs1010337660 1592 dbSNP
rs1475920912 1594 dbSNP
rs30822 1599 dbSNP
rs1412366878 1601 dbSNP
rs1233902980 1602 dbSNP
rs763081862 1604 dbSNP
rs1375505287 1606 dbSNP
rs1416556937 1612 dbSNP
rs1296195188 1627 dbSNP
rs1436649155 1632 dbSNP
rs1033350540 1634 dbSNP
rs1343190117 1638 dbSNP
rs1204770837 1640 dbSNP
rs1001420860 1641 dbSNP
rs905732818 1648 dbSNP
rs1323053343 1650 dbSNP
rs1261534974 1655 dbSNP
rs1045581885 1656 dbSNP
rs117928758 1665 dbSNP
rs896553748 1667 dbSNP
rs1374167232 1679 dbSNP
rs536881346 1683 dbSNP
rs1279105601 1686 dbSNP
rs1439916302 1687 dbSNP
rs775386060 1700 dbSNP
rs760649071 1702 dbSNP
rs1172566024 1704 dbSNP
rs1395163590 1706 dbSNP
rs1337113150 1709 dbSNP
rs1435996988 1714 dbSNP
rs765203161 1725 dbSNP
rs1359878848 1726 dbSNP
rs940697385 1731 dbSNP
rs759290422 1732 dbSNP
rs530676561 1735 dbSNP
rs1049779327 1736 dbSNP
rs1436049597 1737 dbSNP
rs1304362423 1747 dbSNP
rs999201185 1752 dbSNP
rs932248471 1756 dbSNP
rs531850528 1761 dbSNP
rs1352116311 1763 dbSNP
rs1175035385 1767 dbSNP
rs922134276 1772 dbSNP
rs1451326907 1777 dbSNP
rs902990410 1778 dbSNP
rs1469037259 1787 dbSNP
rs1024570033 1789 dbSNP
rs1013587451 1790 dbSNP
rs1362705435 1791 dbSNP
rs1454301946 1794 dbSNP
rs1184550071 1796 dbSNP
rs935502795 1797 dbSNP
rs1160171384 1799 dbSNP
rs145080798 1803 dbSNP
rs912996557 1804 dbSNP
rs561187769 1806 dbSNP
rs80327081 1807 dbSNP
rs938007486 1810 dbSNP
rs1218220799 1811 dbSNP
rs980460027 1812 dbSNP
rs887806099 1815 dbSNP
rs373696603 1816 dbSNP
rs1356119455 1820 dbSNP
rs1361455214 1824 dbSNP
rs1214762181 1830 dbSNP
rs559117980 1831 dbSNP
rs919404997 1832 dbSNP
rs976256077 1833 dbSNP
rs944896003 1849 dbSNP
rs541098722 1853 dbSNP
rs910295381 1854 dbSNP
rs1249228688 1856 dbSNP
rs1451567520 1857 dbSNP
rs1419085243 1863 dbSNP
rs985905685 1866 dbSNP
rs957041658 1868 dbSNP
rs1366692860 1878 dbSNP
rs1380309645 1882 dbSNP
rs1014114986 1883 dbSNP
rs1474819858 1887 dbSNP
rs925626094 1898 dbSNP
rs527885781 1908 dbSNP
rs967705486 1913 dbSNP
rs866355000 1916 dbSNP
rs62065309 1924 dbSNP
rs572802649 1928 dbSNP
rs1393162589 1934 dbSNP
rs1332247556 1936 dbSNP
rs149871814 1943 dbSNP
rs1295564516 1944 dbSNP
rs958567979 1944 dbSNP
rs1316389394 1950 dbSNP
rs1216420310 1952 dbSNP
rs544037902 1954 dbSNP
rs1250376779 1959 dbSNP
rs1480688693 1960 dbSNP
rs887814174 1962 dbSNP
rs1387578202 1973 dbSNP
rs1033713910 1974 dbSNP
rs1253452891 1978 dbSNP
rs1485335567 1988 dbSNP
rs1164788864 1990 dbSNP
rs1188494190 1991 dbSNP
rs1419765320 1995 dbSNP
rs576760282 1998 dbSNP
rs1170035151 1999 dbSNP
rs1373904214 2010 dbSNP
rs1463693462 2019 dbSNP
rs1444322110 2035 dbSNP
rs1241667592 2043 dbSNP
rs1188707887 2047 dbSNP
rs1002269237 2052 dbSNP
rs1315279612 2056 dbSNP
rs900783683 2062 dbSNP
rs1241775762 2065 dbSNP
rs780258329 2066 dbSNP
rs1296694567 2072 dbSNP
rs186864743 2073 dbSNP
rs1049542862 2075 dbSNP
rs993731228 2077 dbSNP
rs1253752378 2080 dbSNP
rs536580745 2081 dbSNP
rs1245144569 2083 dbSNP
rs369396588 2103 dbSNP
rs1259464801 2107 dbSNP
rs1040682493 2111 dbSNP
rs944842729 2123 dbSNP
rs925637496 2124 dbSNP
rs979773430 2135 dbSNP
rs969688695 2144 dbSNP
rs1394568191 2146 dbSNP
rs183690971 2147 dbSNP
rs1050147707 2149 dbSNP
rs1359225035 2156 dbSNP
rs935760298 2157 dbSNP
rs1406185814 2161 dbSNP
rs925605142 2168 dbSNP
rs578242740 2184 dbSNP
rs780675535 2190 dbSNP
rs1424556812 2196 dbSNP
rs1005410331 2197 dbSNP
rs1172936294 2200 dbSNP
rs756720369 2202 dbSNP
rs1214977057 2204 dbSNP
rs1028132746 2209 dbSNP
rs1418996247 2214 dbSNP
rs996148332 2222 dbSNP
rs117711557 2227 dbSNP
rs917158561 2229 dbSNP
rs1189715659 2231 dbSNP
rs1490920464 2232 dbSNP
rs140251526 2234 dbSNP
rs958515608 2235 dbSNP
rs1454847038 2264 dbSNP
rs1195645284 2270 dbSNP
rs944958423 2274 dbSNP
rs3179798 2275 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 55238.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM1065667. RNA binding protein: AGO1. Condition:4-thiouridine ...

- Memczak S; Jens M; Elefsinioti A; Torti F; et al., 2013, Nature.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' acaucacGUUGAUACGUUUUGa 5'
                 ||||   ||||||| 
Target 5' ---uggcCAACACGGCAAAACc 3'
 		1 - 19
Article - Memczak S; Jens M; Elefsinioti A; Torti F; et al.
- Nature, 2013
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.
LinkOut: [PMID: 23446348]
CLIP-seq Support 1 for dataset GSM1065667
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / 4-thiouridine, ML_MM_6
Location of target site ENST00000570101.1 | 3UTR | UGGCCAACACGGCAAAACCCCAU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28544 Breast cancer 0.613 7.2e-4 0.642 3.6e-4 24 Click to see details
GSE26953 Aortic valvular endothelial cells -0.399 2.7e-2 -0.370 3.8e-2 24 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.241 1.2e-1 -0.242 1.2e-1 25 Click to see details
GSE17498 Multiple myeloma -0.138 2.0e-1 -0.201 1.1e-1 40 Click to see details
GSE35602 Colorectal cancer stromal tissue -0.171 2.1e-1 0.367 3.6e-2 25 Click to see details
GSE21687 Ependynoma primary tumors -0.086 2.5e-1 -0.179 7.8e-2 64 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.151 2.6e-1 0.235 1.6e-1 20 Click to see details
GSE38226 Liver fibrosis -0.103 3.3e-1 0.214 1.8e-1 21 Click to see details
GSE19350 CNS germ cell tumors -0.11 3.7e-1 0.322 1.5e-1 12 Click to see details
GSE42095 Differentiated embryonic stem cells -0.041 4.3e-1 0.259 1.2e-1 23 Click to see details
GSE28260 Renal cortex and medulla -0.052 4.3e-1 -0.022 4.7e-1 13 Click to see details
GSE15076 Monocyte-derived dendritic cells -0.13 4.3e-1 0.000 5.0e-1 4 Click to see details
GSE32688 Pancreatic cancer 0.027 4.4e-1 -0.001 5.0e-1 32 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
UCEC 0.87 0.16 1.000 0.5 3 Click to see details
LIHC 0.406 0.3 0.400 0.3 4 Click to see details
LIHC 0.406 0.3 0.400 0.3 4 Click to see details
LIHC 0.406 0.3 0.400 0.3 4 Click to see details
LIHC 0.406 0.3 0.400 0.3 4 Click to see details
LIHC 0.406 0.3 0.400 0.3 4 Click to see details
92 hsa-miR-19a-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT038980 WDR96 cilia and flagella associated protein 43 1 1
MIRT063864 RASSF8 Ras association domain family member 8 2 6
MIRT077656 IGF2BP1 insulin like growth factor 2 mRNA binding protein 1 2 2
MIRT078461 MAP3K3 mitogen-activated protein kinase kinase kinase 3 2 2
MIRT095248 FAM13B family with sequence similarity 13 member B 2 2
MIRT109490 KLHL15 kelch like family member 15 2 6
MIRT155378 CCNT2 cyclin T2 2 2
MIRT163208 EDEM1 ER degradation enhancing alpha-mannosidase like protein 1 2 2
MIRT188326 ARID1A AT-rich interaction domain 1A 2 2
MIRT204723 BZW1 basic leucine zipper and W2 domains 1 2 4
MIRT236399 HMGXB4 HMG-box containing 4 2 2
MIRT237114 P2RY1 purinergic receptor P2Y1 2 5
MIRT286942 SOCS7 suppressor of cytokine signaling 7 2 2
MIRT442523 MOB3B MOB kinase activator 3B 2 2
MIRT473428 MDM4 MDM4, p53 regulator 2 2
MIRT476783 FOS Fos proto-oncogene, AP-1 transcription factor subunit 2 2
MIRT476942 FAM83G family with sequence similarity 83 member G 2 2
MIRT480184 CALM2 calmodulin 2 2 6
MIRT489620 ZNF384 zinc finger protein 384 2 2
MIRT492246 SLC39A9 solute carrier family 39 member 9 2 2
MIRT492422 RGL2 ral guanine nucleotide dissociation stimulator like 2 2 2
MIRT494860 ZNF99 zinc finger protein 99 2 2
MIRT497001 SNAP25 synaptosome associated protein 25 2 2
MIRT501973 MAPK6 mitogen-activated protein kinase 6 2 2
MIRT504917 CD38 CD38 molecule 2 4
MIRT507019 HMGA2 high mobility group AT-hook 2 2 6
MIRT510820 SBNO1 strawberry notch homolog 1 2 4
MIRT514166 PGPEP1 pyroglutamyl-peptidase I 2 2
MIRT514328 PSMG2 proteasome assembly chaperone 2 2 4
MIRT514429 SLC38A7 solute carrier family 38 member 7 2 2
MIRT514537 ESR2 estrogen receptor 2 2 2
MIRT516117 SRPX2 sushi repeat containing protein, X-linked 2 2 4
MIRT517759 ZNF366 zinc finger protein 366 2 4
MIRT518495 FAM161B family with sequence similarity 161 member B 2 4
MIRT518512 CASP10 caspase 10 2 2
MIRT518561 GDPD1 glycerophosphodiester phosphodiesterase domain containing 1 2 2
MIRT518641 NOM1 nucleolar protein with MIF4G domain 1 2 2
MIRT518729 ABCG8 ATP binding cassette subfamily G member 8 2 2
MIRT523565 GGCX gamma-glutamyl carboxylase 2 4
MIRT526523 YIPF6 Yip1 domain family member 6 2 2
MIRT530254 ZNF620 zinc finger protein 620 2 2
MIRT531658 ZFP14 ZFP14 zinc finger protein 2 2
MIRT532699 TCN2 transcobalamin 2 2 4
MIRT534019 STXBP4 syntaxin binding protein 4 2 2
MIRT535748 MYO10 myosin X 2 4
MIRT544509 GTF2E2 general transcription factor IIE subunit 2 2 2
MIRT546758 RLIM ring finger protein, LIM domain interacting 2 2
MIRT547929 HNRNPR heterogeneous nuclear ribonucleoprotein R 2 2
MIRT550130 ZNF138 zinc finger protein 138 2 2
MIRT551763 MED21 mediator complex subunit 21 2 2
MIRT557727 FYCO1 FYVE and coiled-coil domain containing 1 2 2
MIRT558924 CBX1 chromobox 1 2 2
MIRT562466 CORO1C coronin 1C 2 2
MIRT562759 ZNF846 zinc finger protein 846 2 2
MIRT563061 ZNF28 zinc finger protein 28 2 2
MIRT563336 RPLP0 ribosomal protein lateral stalk subunit P0 2 2
MIRT569170 DMD dystrophin 2 2
MIRT573256 TNFAIP6 TNF alpha induced protein 6 2 2
MIRT575057 P2ry1 purinergic receptor P2Y, G-protein coupled 1 2 4
MIRT575360 Zxda zinc finger, X-linked, duplicated A 2 2
MIRT613233 CCDC39 coiled-coil domain containing 39 2 2
MIRT613347 ADRBK2 G protein-coupled receptor kinase 3 2 6
MIRT613952 TMEM59 transmembrane protein 59 2 2
MIRT615488 EDN1 endothelin 1 2 2
MIRT618710 ESD esterase D 2 2
MIRT630609 ARHGAP1 Rho GTPase activating protein 1 2 2
MIRT630619 CXCR6 C-X-C motif chemokine receptor 6 2 2
MIRT630631 IMPAD1 inositol monophosphatase domain containing 1 2 2
MIRT630674 KLF7 Kruppel like factor 7 2 2
MIRT630746 COG6 component of oligomeric golgi complex 6 2 2
MIRT636853 ZSCAN2 zinc finger and SCAN domain containing 2 2 2
MIRT638642 GPATCH8 G-patch domain containing 8 2 2
MIRT639106 MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 2 2
MIRT639422 PKP1 plakophilin 1 2 2
MIRT640187 ABCC12 ATP binding cassette subfamily C member 12 2 2
MIRT641757 SF3A1 splicing factor 3a subunit 1 2 2
MIRT666577 RHOBTB3 Rho related BTB domain containing 3 2 2
MIRT672166 FANCF Fanconi anemia complementation group F 2 2
MIRT688345 ETS1 ETS proto-oncogene 1, transcription factor 2 2
MIRT690120 ZFAND1 zinc finger AN1-type containing 1 2 2
MIRT696939 CERK ceramide kinase 2 2
MIRT701361 NR4A3 nuclear receptor subfamily 4 group A member 3 2 2
MIRT703288 GID4 GID complex subunit 4 homolog 2 2
MIRT709146 ZNF799 zinc finger protein 799 2 2
MIRT710848 FAM210A family with sequence similarity 210 member A 2 2
MIRT712621 GTF2H5 general transcription factor IIH subunit 5 2 2
MIRT714591 CMBL carboxymethylenebutenolidase homolog 2 2
MIRT716909 CACNB2 calcium voltage-gated channel auxiliary subunit beta 2 2 2
MIRT721165 FAM200B family with sequence similarity 200 member B 2 2
MIRT722404 BCAS2 BCAS2, pre-mRNA processing factor 2 2
MIRT722517 DSTYK dual serine/threonine and tyrosine protein kinase 2 2
MIRT724599 AP3B1 adaptor related protein complex 3 beta 1 subunit 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-19a Hydroxamic acid HDACi LAQ824 NULL NULL Microarray breast cancer cell line SKBr3 16452179 2006 down-regulated
miR-19a 5-Fluorouracil approved 3385 Quantitative real-time PCR colon cancer cells 17702597 2007 up-regulated
miR-19a Curcumin NULL 969516 Microarray BxPC-3 human pancreatic carcinoma cell line 18347134 2008 down-regulated
miR-19a 5-aza-2'-deoxycytidine (5-Aza-CdR) approved 451668 Microarray Pancreatic Cancer MiaPACA-2 cells 19407485 2009 up-regulated
miR-19a 5-aza-2'-deoxycytidine (5-Aza-CdR) + trichostatin A(TSA) NULL NULL Microarray Pancreatic Cancer MiaPACA-2 cells 19407485 2009 up-regulated
miR-19a Trichostatin A (TSA) NULL 444732 Microarray Pancreatic Cancer MiaPACA-2 cells 19407485 2009 up-regulated
miR-19a Histone deacetylase inhibitor ITF2357 NULL 9804992 Quantitative real-time PCR multiple myeloma 19713220 2009 down-regulated
miR-19a Activin A NULL 229455 Quantitative real-time PCR Human embryonic stem (hES) cells 19885849 2010 up-regulated
miR-19a Arsenic trioxide approved 14888 Quantitative real-time PCR bladder cancer cell line T24 20857258 2011 down-regulated
miR-19a Ibandronate approved 60852 Quantitative real-time PCR Periodontal ligament stem cells (PDLSCs) 21108928 2011 down-regulated
miR-19a Formaldehyde NULL 712 Microarray Human lung epithelial cells (A549) 21147603 2011 down-regulated
miR-19a 5-azacytidine (5-AzaC) approved 9444 Quantitative real-time PCR chronic myeloid leukemia (CML)K562 cell line 21176349 2011 down-regulated
miR-19a Arsenic trioxide approved 14888 Quantitative real-time PCR acute promyelocytic leukemia 22072212 2012 up-regulated
miR-19a 1,2,6-Tri-O-galloyl-beta-D-glucopyranose NULL NULL Microarray HepG2 hepatocarcinoma cells. 22506400 2011 down-regulated
miR-19a Vitamin D3 approved 5280795 Quantitative real-time PCR Plasma 22594500 2012 down-regulated
miR-19a (S)-3,5-dihydroxyphenylglycine (DHPG) NULL 443586 Quantitative real-time PCR mouse brain 22309833 2012 down-regulated
miR-19a Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 down-regulated
miR-19a Isoproterenol approved 3779 Quantitative real-time PCR heart 22847192 2012 up-regulated
miR-19a Dexamethasone approved 5743 Quantitative real-time PCR adrenals and granulosa cells 24205079 2014 down-regulated
miR-19a Arsenic trioxide approved 14888 Microarray bladder cancer cell line T24 20857258 2011 down-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-19a Paclitaxel 36314 NSC125973 approved sensitive cell line (A2780)
hsa-miR-19a-5p Imatinib 5291 NSC743414 approved sensitive High Chronic Myelogenous Leukemia cell line (K562)
hsa-miR-19a-5p Fluorouracil 3385 NSC19893 approved resistant Low Colorectal Cancer cell line (HCT-8)
hsa-miR-19a-5p Oxaliplatin 6857599 NSC266046 approved sensitive Low Colorectal Cancer cell line (SW480)
hsa-miR-19a-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (451Lu)
hsa-miR-19a-5p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-19a-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-19a-5p Sunitinib 5329102 NSC750690 approved resistant tissue (CardB)
hsa-miR-19a-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-19a-5p Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)

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