miRTarBase - #MIRT514626


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pre-miRNA Information
pre-miRNA hsa-mir-4680   
Genomic Coordinates chr10: 110898090 - 110898155
Description Homo sapiens miR-4680 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4680-5p
Sequence 5| AGAACUCUUGCAGUCUUAGAUGU |27
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1274530692 2 dbSNP
rs780271274 5 dbSNP
rs1461423681 7 dbSNP
rs749729920 8 dbSNP
rs1252920446 10 dbSNP
rs201739274 11 dbSNP
rs774971106 19 dbSNP
rs748132091 22 dbSNP
rs773643180 22 dbSNP
rs1235425484 23 dbSNP
Putative Targets

Gene Information
Gene Symbol MTRNR2L7   
Synonyms HN7
Description MT-RNR2-like 7
Transcript NM_001190489   
Expression
Putative miRNA Targets on MTRNR2L7
3'UTR of MTRNR2L7
(miRNA target sites are highlighted)		 
>MTRNR2L7|NM_001190489|3'UTR
   1 ACAAATAAGATGAGAAGCTCCCTATGGAGCTTTAATTCATTAATGCAAATTAAAACTCAAACAAGCCTACAGGCTCTAGC
  81 CTACTATTCTTGCATTAAAAATTTTGGTTGGGGTGACCTTGGAGCATAATTCAACCTCTGAACAACCTACACTAAGACTG
 161 CACTAGTCTAAGTGAGTTAATACATATGGACCCAATAATTTGATCAACAGAGTAAGGTACCCTAGGGATAACAGCACAAT
 241 CCATTCTACAGTTCATATTGACAATAGGGTTTATGACCTTGATGTTAGATCAGGACATCCTAATGGTGTAACCACTGTTA
 321 AGGATTCATTTATTCAATGATTAAAGTCAATTAATGTGATCTGAGTTCAGACTGGAGTAATCCAGGTTGGTTTCTATCTA
 401 TTTAACATTTCTCCAAGTATGAAAGGACAAGAGAAATAGAGTCCCTTTCATAAAGTGCCCTCACTTCATAGAGGATGCTA
 481 TCTCAATCTAAAAAATCATCACCACCCTACCCAAGAACAGGGTTTGTTAAGA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' ugUAGAUUCUGAC-GU--UCUCAAGa 5'
            | :| | |:|| ||  ||:|||: 
Target 5' acAGTTCATATTGACAATAGGGTTTa 3'
 248 - 273 123.00 -7.60
2 
miRNA  3' uguagauucugacguuCUCAAGa 5'
                          |||||| 
Target 5' tcaattaatgtgatctGAGTTCa 3'
 347 - 369 120.00 -6.90
3 
miRNA  3' uguaGAUUCUGACGU----------UCUCAAga 5'
              |||||||||||           |||||  
Target 5' tacaCTAAGACTGCACTAGTCTAAGTGAGTTaa 3'
 148 - 180 117.00 -19.57
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN4714182 81 COSMIC
COSN4714181 102 COSMIC
COSN22027591 169 COSMIC
COSN5251008 215 COSMIC
COSN5819023 220 COSMIC
COSN16821682 237 COSMIC
COSN19088399 267 COSMIC
COSN29472341 369 COSMIC
COSN22450187 425 COSMIC
COSN21724845 427 COSMIC
COSN10067030 497 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1250441224 2 dbSNP
rs1215458620 4 dbSNP
rs1204867825 6 dbSNP
rs564118733 11 dbSNP
rs1289488017 12 dbSNP
rs765273296 20 dbSNP
rs1382085553 23 dbSNP
rs544235173 29 dbSNP
rs1397893945 38 dbSNP
rs141027489 39 dbSNP
rs1367701072 44 dbSNP
rs1371376350 46 dbSNP
rs1216093116 47 dbSNP
rs936878780 54 dbSNP
rs1216296695 55 dbSNP
rs923945579 58 dbSNP
rs1042403685 62 dbSNP
rs1419008800 65 dbSNP
rs1279805324 68 dbSNP
rs1161947648 71 dbSNP
rs1413209495 72 dbSNP
rs562940293 73 dbSNP
rs1358786525 75 dbSNP
rs1399626850 76 dbSNP
rs776542861 78 dbSNP
rs562488649 87 dbSNP
rs949486663 91 dbSNP
rs1258652159 97 dbSNP
rs917993763 113 dbSNP
rs1223785330 114 dbSNP
rs1351124993 116 dbSNP
rs1215409744 120 dbSNP
rs991284173 122 dbSNP
rs1486837008 129 dbSNP
rs959254817 132 dbSNP
rs1237358677 134 dbSNP
rs919715973 139 dbSNP
rs974027388 158 dbSNP
rs138101583 163 dbSNP
rs1007833142 165 dbSNP
rs955151625 171 dbSNP
rs1375858824 185 dbSNP
rs1397500760 192 dbSNP
rs573762670 196 dbSNP
rs1334572031 199 dbSNP
rs1339869048 201 dbSNP
rs1442816349 209 dbSNP
rs1310874288 211 dbSNP
rs1399965788 213 dbSNP
rs1239021437 219 dbSNP
rs1280543543 225 dbSNP
rs1347601183 227 dbSNP
rs574645710 228 dbSNP
rs1278358321 234 dbSNP
rs1028040226 235 dbSNP
rs996976219 237 dbSNP
rs1439109067 246 dbSNP
rs1194518973 250 dbSNP
rs900670011 259 dbSNP
rs1160729623 261 dbSNP
rs553794922 263 dbSNP
rs539973404 264 dbSNP
rs577839030 266 dbSNP
rs557769155 267 dbSNP
rs537879934 269 dbSNP
rs1401203367 275 dbSNP
rs1410502203 279 dbSNP
rs1054328532 281 dbSNP
rs1001157655 291 dbSNP
rs1474065063 292 dbSNP
rs902764857 298 dbSNP
rs1042435274 299 dbSNP
rs949379049 305 dbSNP
rs76786446 312 dbSNP
rs11011277 316 dbSNP
rs938061131 320 dbSNP
rs11599739 323 dbSNP
rs796532405 332 dbSNP
rs192958562 334 dbSNP
rs974312457 337 dbSNP
rs553835103 338 dbSNP
rs1363938960 342 dbSNP
rs1431706809 350 dbSNP
rs761637753 360 dbSNP
rs1198384342 366 dbSNP
rs1226471179 371 dbSNP
rs547200561 372 dbSNP
rs1284770517 374 dbSNP
rs1030606833 377 dbSNP
rs1397941848 385 dbSNP
rs1326068287 388 dbSNP
rs1429738467 390 dbSNP
rs1384761730 391 dbSNP
rs908456790 395 dbSNP
rs975136673 400 dbSNP
rs964775566 401 dbSNP
rs533237241 407 dbSNP
rs189041056 409 dbSNP
rs1276688988 413 dbSNP
rs955057286 418 dbSNP
rs1234413154 422 dbSNP
rs1267343338 431 dbSNP
rs1016300249 439 dbSNP
rs1209496523 440 dbSNP
rs1262623983 441 dbSNP
rs1488497477 443 dbSNP
rs1006264662 444 dbSNP
rs1421195851 446 dbSNP
rs886237744 452 dbSNP
rs747953660 454 dbSNP
rs1301373997 455 dbSNP
rs1026116178 457 dbSNP
rs570653778 458 dbSNP
rs907095198 463 dbSNP
rs550559216 464 dbSNP
rs1292584988 477 dbSNP
rs1042679699 478 dbSNP
rs751467951 480 dbSNP
rs948389796 481 dbSNP
rs1340258705 492 dbSNP
rs892811145 494 dbSNP
rs565995458 496 dbSNP
rs1055529316 498 dbSNP
rs10827804 500 dbSNP
rs934411856 501 dbSNP
rs924083317 502 dbSNP
rs562759266 505 dbSNP
rs577614012 506 dbSNP
rs1487818435 519 dbSNP
rs1452878894 525 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 100288485.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM1065667. RNA binding protein: AGO1. Condition:4-thiouridine ...

- Memczak S; Jens M; Elefsinioti A; Torti F; et al., 2013, Nature.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' uguaGAUUCUGACGUUCUCAaga 5'
              :| |||||   :||||   
Target 5' ---gUUCAGACU---GGAGUaau 3'
 		1 - 17
Article - Memczak S; Jens M; Elefsinioti A; Torti F; et al.
- Nature, 2013
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.
LinkOut: [PMID: 23446348]
CLIP-seq Support 1 for dataset GSM1065667
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / 4-thiouridine, ML_MM_6
Location of target site ENST00000544824.1 | 3UTR | GUUCAGACUGGAGUAAUCCAGGUUGGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
133 hsa-miR-4680-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT378771 MACC1 MACC1, MET transcriptional regulator 2 2
MIRT393867 ZDHHC21 zinc finger DHHC-type containing 21 2 4
MIRT446684 C2CD2 C2 calcium dependent domain containing 2 2 2
MIRT447600 MRPL3 mitochondrial ribosomal protein L3 2 2
MIRT450708 RNF152 ring finger protein 152 2 2
MIRT450784 PAPOLG poly(A) polymerase gamma 2 2
MIRT454623 COL23A1 collagen type XXIII alpha 1 chain 2 8
MIRT461620 PTCD3 pentatricopeptide repeat domain 3 2 2
MIRT462695 SNRPD3 small nuclear ribonucleoprotein D3 polypeptide 2 2
MIRT475530 HOXA3 homeobox A3 2 8
MIRT475739 HERPUD1 homocysteine inducible ER protein with ubiquitin like domain 1 2 4
MIRT489676 CYP1A1 cytochrome P450 family 1 subfamily A member 1 2 2
MIRT490610 SLC47A1 solute carrier family 47 member 1 2 2
MIRT493628 HIC2 HIC ZBTB transcriptional repressor 2 2 2
MIRT496152 RPS15A ribosomal protein S15a 2 2
MIRT499232 VAV3 vav guanine nucleotide exchange factor 3 2 4
MIRT501496 PRICKLE2 prickle planar cell polarity protein 2 2 2
MIRT507163 GAS2L3 growth arrest specific 2 like 3 2 2
MIRT512389 MTRNR2L1 MT-RNR2-like 1 2 4
MIRT514626 MTRNR2L7 MT-RNR2-like 7 2 2
MIRT517474 PEX26 peroxisomal biogenesis factor 26 2 2
MIRT525332 CNGB1 cyclic nucleotide gated channel beta 1 2 2
MIRT526685 BAK1 BCL2 antagonist/killer 1 2 2
MIRT527317 CCR2 C-C motif chemokine receptor 2 2 2
MIRT527608 EYS eyes shut homolog (Drosophila) 2 2
MIRT528794 RAB32 RAB32, member RAS oncogene family 2 2
MIRT531048 TIPARP TCDD inducible poly(ADP-ribose) polymerase 2 2
MIRT532254 TBPL2 TATA-box binding protein like 2 2 2
MIRT533801 TMED7 transmembrane p24 trafficking protein 7 2 4
MIRT535887 MLEC malectin 2 2
MIRT540704 PDPK1 3-phosphoinositide dependent protein kinase 1 2 4
MIRT544645 PHF8 PHD finger protein 8 2 4
MIRT545760 HS3ST1 heparan sulfate-glucosamine 3-sulfotransferase 1 2 2
MIRT555310 PPP2R5C protein phosphatase 2 regulatory subunit B'gamma 2 2
MIRT555877 PAFAH1B2 platelet activating factor acetylhydrolase 1b catalytic subunit 2 2 4
MIRT559507 ARID5B AT-rich interaction domain 5B 2 2
MIRT560448 SLC30A7 solute carrier family 30 member 7 2 2
MIRT561262 ZIK1 zinc finger protein interacting with K protein 1 2 2
MIRT561795 PAWR pro-apoptotic WT1 regulator 2 2
MIRT567007 KLHL15 kelch like family member 15 2 2
MIRT569298 SURF6 surfeit 6 2 2
MIRT570606 MTRNR2L11 MT-RNR2-like 11 2 2
MIRT572888 ADCY2 adenylate cyclase 2 2 2
MIRT573119 ADAMTS18 ADAM metallopeptidase with thrombospondin type 1 motif 18 2 2
MIRT608332 ZNF670 zinc finger protein 670 2 6
MIRT614942 KCNK5 potassium two pore domain channel subfamily K member 5 2 2
MIRT615324 ERN1 endoplasmic reticulum to nucleus signaling 1 2 2
MIRT618441 ZNF800 zinc finger protein 800 2 2
MIRT620110 HARBI1 harbinger transposase derived 1 2 2
MIRT626008 ZNF517 zinc finger protein 517 2 2
MIRT626626 SLC30A6 solute carrier family 30 member 6 2 2
MIRT627842 POU3F1 POU class 3 homeobox 1 2 2
MIRT628386 CACNB2 calcium voltage-gated channel auxiliary subunit beta 2 2 2
MIRT629305 PTPLAD2 3-hydroxyacyl-CoA dehydratase 4 1 1
MIRT629864 GATAD1 GATA zinc finger domain containing 1 2 2
MIRT630444 IDE insulin degrading enzyme 2 2
MIRT631854 PIGG phosphatidylinositol glycan anchor biosynthesis class G 2 2
MIRT633173 AGO3 argonaute 3, RISC catalytic component 2 2
MIRT633477 ZNF724P zinc finger protein 724 2 2
MIRT634395 PLSCR1 phospholipid scramblase 1 2 2
MIRT635538 TRIM72 tripartite motif containing 72 2 2
MIRT635821 OPA3 OPA3, outer mitochondrial membrane lipid metabolism regulator 2 2
MIRT636169 TIMM8A translocase of inner mitochondrial membrane 8A 2 2
MIRT636797 CYB5D1 cytochrome b5 domain containing 1 2 2
MIRT637952 IVD isovaleryl-CoA dehydrogenase 2 2
MIRT645136 HES2 hes family bHLH transcription factor 2 2 2
MIRT645667 ADK adenosine kinase 2 2
MIRT646148 FLVCR1 feline leukemia virus subgroup C cellular receptor 1 2 2
MIRT647004 NCR3LG1 natural killer cell cytotoxicity receptor 3 ligand 1 2 2
MIRT648187 C2orf68 chromosome 2 open reading frame 68 2 2
MIRT650090 TERF2 telomeric repeat binding factor 2 2 2
MIRT650329 RTN2 reticulon 2 2 2
MIRT654224 RNF165 ring finger protein 165 2 2
MIRT654545 RAB1A RAB1A, member RAS oncogene family 2 2
MIRT656457 MAPK14 mitogen-activated protein kinase 14 2 2
MIRT656828 KLF8 Kruppel like factor 8 2 2
MIRT657112 ITPRIPL2 inositol 1,4,5-trisphosphate receptor interacting protein like 2 2 2
MIRT657930 GATSL2 cytosolic arginine sensor for mTORC1 subunit 2 2 2
MIRT659375 CREG2 cellular repressor of E1A stimulated genes 2 2 2
MIRT659833 CARHSP1 calcium regulated heat stable protein 1 2 2
MIRT662108 LACTB lactamase beta 2 4
MIRT662789 TBC1D25 TBC1 domain family member 25 2 2
MIRT669501 ARL3 ADP ribosylation factor like GTPase 3 2 2
MIRT669759 ZNF101 zinc finger protein 101 2 4
MIRT669800 GAN gigaxonin 2 2
MIRT670050 RPP14 ribonuclease P/MRP subunit p14 2 2
MIRT670299 RBBP4 RB binding protein 4, chromatin remodeling factor 2 2
MIRT670388 EMP2 epithelial membrane protein 2 2 2
MIRT672862 C22orf29 retrotransposon Gag like 10 2 2
MIRT672890 FXN frataxin 2 2
MIRT673210 C10orf76 chromosome 10 open reading frame 76 2 2
MIRT674001 KCNN3 potassium calcium-activated channel subfamily N member 3 2 2
MIRT674163 BLOC1S3 biogenesis of lysosomal organelles complex 1 subunit 3 2 2
MIRT674502 TIRAP TIR domain containing adaptor protein 2 2
MIRT675470 NUBPL nucleotide binding protein like 2 2
MIRT675671 TMOD2 tropomodulin 2 2 2
MIRT676006 CRKL CRK like proto-oncogene, adaptor protein 2 2
MIRT676074 TIMM50 translocase of inner mitochondrial membrane 50 2 2
MIRT676386 SEC24D SEC24 homolog D, COPII coat complex component 2 2
MIRT676764 SNX2 sorting nexin 2 2 2
MIRT676896 GABPB1 GA binding protein transcription factor beta subunit 1 2 2
MIRT676978 ZNF708 zinc finger protein 708 2 2
MIRT677236 C15orf40 chromosome 15 open reading frame 40 2 2
MIRT677369 HSPA4L heat shock protein family A (Hsp70) member 4 like 2 2
MIRT677464 PDLIM3 PDZ and LIM domain 3 2 2
MIRT678081 EIF2A eukaryotic translation initiation factor 2A 2 2
MIRT678093 ATCAY ATCAY, caytaxin 2 2
MIRT678324 FBLIM1 filamin binding LIM protein 1 2 2
MIRT678417 ANKRD36 ankyrin repeat domain 36 2 2
MIRT678521 ZNF347 zinc finger protein 347 2 2
MIRT678700 TRIP11 thyroid hormone receptor interactor 11 2 2
MIRT678829 PDE6A phosphodiesterase 6A 2 2
MIRT679991 RUNDC1 RUN domain containing 1 2 2
MIRT680751 PSD4 pleckstrin and Sec7 domain containing 4 2 2
MIRT681249 ZNF383 zinc finger protein 383 2 2
MIRT681422 GTF3C6 general transcription factor IIIC subunit 6 2 2
MIRT681948 SLC19A3 solute carrier family 19 member 3 2 2
MIRT689278 C5AR2 complement component 5a receptor 2 2 2
MIRT690389 PARP15 poly(ADP-ribose) polymerase family member 15 2 2
MIRT691845 OSCAR osteoclast associated, immunoglobulin-like receptor 2 2
MIRT693863 IYD iodotyrosine deiodinase 2 2
MIRT696002 DNAJC10 DnaJ heat shock protein family (Hsp40) member C10 2 2
MIRT701930 MLLT1 MLLT1, super elongation complex subunit 2 2
MIRT702341 KLHL7 kelch like family member 7 2 2
MIRT703557 FKBP14 FK506 binding protein 14 2 2
MIRT705033 CACUL1 CDK2 associated cullin domain 1 2 2
MIRT706341 STAC2 SH3 and cysteine rich domain 2 2 2
MIRT709671 RGP1 RGP1 homolog, RAB6A GEF complex partner 1 2 2
MIRT711212 EFHB EF-hand domain family member B 2 2
MIRT718342 PURA purine rich element binding protein A 2 2
MIRT722755 SIRPB2 signal regulatory protein beta 2 2 2
MIRT723535 NFATC2IP nuclear factor of activated T-cells 2 interacting protein 2 2
MIRT724498 BFAR bifunctional apoptosis regulator 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4680-5p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)

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