pre-miRNA Information | |
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pre-miRNA | hsa-mir-2115 |
Genomic Coordinates | chr3: 48316360 - 48316459 |
Description | Homo sapiens miR-2115 stem-loop |
Comment | None |
RNA Secondary Structure | ![]() |
Mature miRNA Information | ||||||||||
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Mature miRNA | hsa-miR-2115-3p | |||||||||
Sequence | 58| CAUCAGAAUUCAUGGAGGCUAG |79 | |||||||||
Evidence | Experimental | |||||||||
Experiments | 454 | DRVs in miRNA |
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SNPs in miRNA |
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Putative Targets |
miRNA Expression profile | |
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miRNAs in Extracellular Vesicles |
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Circulating MicroRNA Expression Profiling |
Gene Information | |||||||||||||||||||||
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Gene Symbol | RAB42 | ||||||||||||||||||||
Synonyms | - | ||||||||||||||||||||
Description | RAB42, member RAS oncogene family | ||||||||||||||||||||
Transcript | NM_152304 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on RAB42 | |||||||||||||||||||||
3'UTR of RAB42 (miRNA target sites are highlighted) |
>RAB42|NM_152304|3'UTR 1 CTCTAGGAGAGAAAGGGTTAAAGCAGTCCCAGCCTTAGCCCACCTGGTGGGATGGGGAGTGTTAATATCTCTCTGGAGGA 81 CAAATGACAGAAGGGTTCATATAAACAGTATCCTGACACAGTCATGCTTCCTGGATTTTGGAGTCGAGGCTTTCTACAGA 161 AAAGAAAGTTCTGATGGCCAGGCATGGTGGCTCACGCCTGTAATCCTAGCATTTTTGGAGGCCAAGGACAGTGGATCACC 241 TGAGGTCAGGGGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCTGTCTCTACTAAAAATACAAAAATTAGCCAGGCGT 321 GGTGGTGCATGCCTGTAATCCCAGTTACTCCAGAGGCTAAGGCAGGAGAATTGCTTGAACCTGGGAGGCAGAGATTGCAG 401 TGAGCCAAGACTGCGCCACTGCACTCCAGCCTGGGCAACAGAGTGAGACTCTGTTTCAAAAAAAAAAAAGAAAAGAAAAG 481 AAAGGCCTGAGAGACCAGATGTGCAACTTCCTGTCCTTGAGCCTCAGTGTCCCTATCTATCGATGGGGCTCATAAAAGAT 561 CCCACCTTGAAGGGAGGTGGTGACCACAAATGAGACAGTGGACAGGATGTGCTCACCCAGAGCCTGCCGCGCTGTGAATT 641 GAATGACAAAAGCTCTCATTCCCACTCCCTTTTTCTTGGCTGCGATGTGGCCACTCTGGCAGCATTCCTGGGCTCAGACA 721 CTGAGAAGCCAGCGTCAGGAAGCTGATGCATGGGCAAAGGCAGGTGCGGGGAATTCCAGGGGGAGCTTGGCTTGGAGGCT 801 TCTTATGTCCTCAGGCTAAAATGATTCTGGGCATGGGATTAATATGTGACGTCAAACCCAGGGTTGCTGGCCAATGCCCC 881 CCCGACCAGGCCCAGGGGCTGAAAAATGGATGTTGGAGGCTGGGATGAACATGAATGTGTAGCAACTATGTTGGGCACAC 961 AGTGGCCACTGTGATGAGCCACCAAGATCCCCCTTTCTGGCTGGGGAACCCATCAACCCTCTCCCCAGCTGCTGGAGTGC 1041 CACTGGATGATGGACTTCAGCTTGCCCCACTCTCTGGGAAAGGCCCTCCCTTCAGGGCAGCTTGTATCCAAAGTTCATCT 1121 CCTGGGGGGCCTTAAAGGACTCCCTCTTGCCCCAGCTCTGGACAACTCTGAAAGTCAAAACCAACTTTATCAGTCTCTGT 1201 GGGCTTCATTGAGGACACTGTTGTGACATCATAGCCAAGTTATCCCCTTGCCCAATCCTGCTTCCTTTTCTTCCCCAAAC 1281 AGGTATCCATTTCAAGAATATCCCCTAATAAACATCTGCACACTCAAAAAAAAAAAAAAA Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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DRVs in gene 3'UTRs | |||||||||||||||||||||
SNPs in gene 3'UTRs |
Experimental Support 1 for Functional miRNA-Target Interaction | |||||||
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miRNA:Target | ---- | ||||||
Validation Method |
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Conditions | HEK293 | ||||||
Disease | 115273.0 | ||||||
Location of target site | 3'UTR | ||||||
Tools used in this research | TargetScan , miRTarCLIP , Piranha | ||||||
Original Description (Extracted from the article) |
...
"PAR-CLIP data was present in GSM1065667. RNA binding protein: AGO1. Condition:4-thiouridine
... - Memczak S; Jens M; Elefsinioti A; Torti F; et al., 2013, Nature. |
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miRNA-target interactions (Provided by authors) |
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Article |
- Memczak S; Jens M; Elefsinioti A; Torti F; et al. - Nature, 2013
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.
LinkOut: [PMID: 23446348]
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CLIP-seq Support 1 for dataset GSM1065667 | |
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Method / RBP | PAR-CLIP / AGO1 |
Cell line / Condition | HEK293 / 4-thiouridine, ML_MM_6 |
Location of target site | ENST00000373826.3 | 3UTR | AUGGCCAGGCAUGGUGGCUCAC |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23446348 / GSE43573 |
CLIP-seq Viewer | Link |
MiRNA-Target Expression Profile | |||||||
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MiRNA-Target Expression Profile (TCGA) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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80 hsa-miR-2115-3p Target Genes:
Functional analysis:
ID![]() |
Target | Description | Validation methods |
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Strong evidence | Less strong evidence | |||||||||||
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MIRT057089 | DDIT4 | DNA damage inducible transcript 4 | ![]() |
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2 | 2 | ||||||
MIRT071216 | FCF1 | FCF1, rRNA-processing protein | ![]() |
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2 | 2 | ||||||
MIRT226901 | RAD23B | RAD23 homolog B, nucleotide excision repair protein | ![]() |
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2 | 2 | ||||||
MIRT235961 | BACH1 | BTB domain and CNC homolog 1 | ![]() |
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2 | 2 | ||||||
MIRT294569 | ZNF460 | zinc finger protein 460 | ![]() |
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2 | 4 | ||||||
MIRT321046 | RAC1 | Rac family small GTPase 1 | ![]() |
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2 | 4 | ||||||
MIRT359666 | NUS1 | NUS1 dehydrodolichyl diphosphate synthase subunit | ![]() |
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2 | 8 | ||||||
MIRT366451 | KLHL15 | kelch like family member 15 | ![]() |
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2 | 2 | ||||||
MIRT405375 | ZBTB18 | zinc finger and BTB domain containing 18 | ![]() |
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2 | 2 | ||||||
MIRT441794 | TCEAL5 | transcription elongation factor A like 5 | ![]() |
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2 | 2 | ||||||
MIRT443295 | TCEAL3 | transcription elongation factor A like 3 | ![]() |
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2 | 2 | ||||||
MIRT455275 | DDX39B | DExD-box helicase 39B | ![]() |
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2 | 2 | ||||||
MIRT458523 | C5orf22 | chromosome 5 open reading frame 22 | ![]() |
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2 | 2 | ||||||
MIRT464960 | TWIST1 | twist family bHLH transcription factor 1 | ![]() |
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2 | 2 | ||||||
MIRT466848 | STX6 | syntaxin 6 | ![]() |
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2 | 2 | ||||||
MIRT469252 | RHOB | ras homolog family member B | ![]() |
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2 | 2 | ||||||
MIRT469825 | RAB14 | RAB14, member RAS oncogene family | ![]() |
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2 | 4 | ||||||
MIRT470047 | PTGFRN | prostaglandin F2 receptor inhibitor | ![]() |
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2 | 2 | ||||||
MIRT471420 | PDP2 | pyruvate dehyrogenase phosphatase catalytic subunit 2 | ![]() |
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2 | 2 | ||||||
MIRT472024 | NPM1 | nucleophosmin 1 | ![]() |
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2 | 2 | ||||||
MIRT484156 | CENPN | centromere protein N | ![]() |
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2 | 2 | ||||||
MIRT485490 | HMGN2 | high mobility group nucleosomal binding domain 2 | ![]() |
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2 | 2 | ||||||
MIRT490462 | PROSER2 | proline and serine rich 2 | ![]() |
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2 | 2 | ||||||
MIRT493069 | MTCH1 | mitochondrial carrier 1 | ![]() |
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2 | 2 | ||||||
MIRT493573 | HSP90AA1 | heat shock protein 90 alpha family class A member 1 | ![]() |
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2 | 8 | ||||||
MIRT494919 | NDUFC2-KCTD14 | NDUFC2-KCTD14 readthrough | ![]() |
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2 | 2 | ||||||
MIRT500439 | ZMAT3 | zinc finger matrin-type 3 | ![]() |
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2 | 2 | ||||||
MIRT500931 | SRPR | SRP receptor alpha subunit | ![]() |
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2 | 4 | ||||||
MIRT501551 | POC1B-GALNT4 | POC1B-GALNT4 readthrough | ![]() |
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2 | 2 | ||||||
MIRT501809 | NEURL1B | neuralized E3 ubiquitin protein ligase 1B | ![]() |
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2 | 2 | ||||||
MIRT502415 | GALNT4 | polypeptide N-acetylgalactosaminyltransferase 4 | ![]() |
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2 | 2 | ||||||
MIRT506504 | MSANTD4 | Myb/SANT DNA binding domain containing 4 with coiled-coils | ![]() |
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2 | 2 | ||||||
MIRT507861 | CCNE2 | cyclin E2 | ![]() |
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2 | 2 | ||||||
MIRT510511 | YOD1 | YOD1 deubiquitinase | ![]() |
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2 | 6 | ||||||
MIRT516073 | RAB42 | RAB42, member RAS oncogene family | ![]() |
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2 | 2 | ||||||
MIRT519030 | KYNU | kynureninase | ![]() |
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2 | 6 | ||||||
MIRT521762 | PPIL1 | peptidylprolyl isomerase like 1 | ![]() |
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2 | 4 | ||||||
MIRT522898 | KCNJ3 | potassium voltage-gated channel subfamily J member 3 | ![]() |
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2 | 4 | ||||||
MIRT527370 | MGARP | mitochondria localized glutamic acid rich protein | ![]() |
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2 | 2 | ||||||
MIRT530691 | C8orf46 | chromosome 8 open reading frame 46 | ![]() |
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2 | 2 | ||||||
MIRT530867 | TRUB1 | TruB pseudouridine synthase family member 1 | ![]() |
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2 | 2 | ||||||
MIRT531832 | MTPAP | mitochondrial poly(A) polymerase | ![]() |
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2 | 4 | ||||||
MIRT533035 | ZBTB5 | zinc finger and BTB domain containing 5 | ![]() |
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2 | 2 | ||||||
MIRT533165 | WIPF2 | WAS/WASL interacting protein family member 2 | ![]() |
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2 | 2 | ||||||
MIRT533464 | TRIM71 | tripartite motif containing 71 | ![]() |
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2 | 2 | ||||||
MIRT534331 | SHCBP1 | SHC binding and spindle associated 1 | ![]() |
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2 | 2 | ||||||
MIRT539372 | ADSS | adenylosuccinate synthase | ![]() |
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2 | 6 | ||||||
MIRT545951 | ZBTB10 | zinc finger and BTB domain containing 10 | ![]() |
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2 | 2 | ||||||
MIRT553283 | TSR1 | TSR1, ribosome maturation factor | ![]() |
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2 | 2 | ||||||
MIRT553532 | TMEM185B | transmembrane protein 185B | ![]() |
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2 | 4 | ||||||
MIRT556480 | LIPA | lipase A, lysosomal acid type | ![]() |
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2 | 2 | ||||||
MIRT556975 | HSPA4L | heat shock protein family A (Hsp70) member 4 like | ![]() |
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2 | 2 | ||||||
MIRT557697 | GATA6 | GATA binding protein 6 | ![]() |
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2 | 2 | ||||||
MIRT558901 | CCDC58 | coiled-coil domain containing 58 | ![]() |
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2 | 2 | ||||||
MIRT559224 | BLMH | bleomycin hydrolase | ![]() |
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2 | 2 | ||||||
MIRT559827 | SLPI | secretory leukocyte peptidase inhibitor | ![]() |
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2 | 2 | ||||||
MIRT563435 | SLC3A2 | solute carrier family 3 member 2 | ![]() |
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2 | 2 | ||||||
MIRT569270 | PCDH11X | protocadherin 11 X-linked | ![]() |
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2 | 2 | ||||||
MIRT571386 | JKAMP | JNK1/MAPK8-associated membrane protein | ![]() |
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2 | 2 | ||||||
MIRT572567 | AFF1 | AF4/FMR2 family member 1 | ![]() |
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2 | 2 | ||||||
MIRT610400 | AR | androgen receptor | ![]() |
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2 | 2 | ||||||
MIRT611058 | ZNF621 | zinc finger protein 621 | ![]() |
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2 | 2 | ||||||
MIRT635118 | TMEM233 | transmembrane protein 233 | ![]() |
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2 | 2 | ||||||
MIRT641617 | DEFB118 | defensin beta 118 | ![]() |
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2 | 2 | ||||||
MIRT642146 | CHORDC1 | cysteine and histidine rich domain containing 1 | ![]() |
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2 | 2 | ||||||
MIRT647295 | C8orf33 | chromosome 8 open reading frame 33 | ![]() |
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2 | 2 | ||||||
MIRT648155 | MPLKIP | M-phase specific PLK1 interacting protein | ![]() |
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2 | 2 | ||||||
MIRT652780 | TENM3 | teneurin transmembrane protein 3 | ![]() |
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2 | 2 | ||||||
MIRT657356 | HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | ![]() |
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2 | 2 | ||||||
MIRT658718 | ELN | elastin | ![]() |
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2 | 2 | ||||||
MIRT662441 | RALGAPA1 | Ral GTPase activating protein catalytic alpha subunit 1 | ![]() |
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2 | 2 | ||||||
MIRT665302 | ZBTB38 | zinc finger and BTB domain containing 38 | ![]() |
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2 | 2 | ||||||
MIRT699898 | RUNX1 | runt related transcription factor 1 | ![]() |
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2 | 2 | ||||||
MIRT700921 | PDS5A | PDS5 cohesin associated factor A | ![]() |
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2 | 2 | ||||||
MIRT700992 | PDE3A | phosphodiesterase 3A | ![]() |
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2 | 2 | ||||||
MIRT707397 | DCAF4L1 | DDB1 and CUL4 associated factor 4 like 1 | ![]() |
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2 | 2 | ||||||
MIRT711895 | INSIG2 | insulin induced gene 2 | ![]() |
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2 | 2 | ||||||
MIRT712072 | XRCC5 | X-ray repair cross complementing 5 | ![]() |
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2 | 2 | ||||||
MIRT716121 | PTPLAD2 | 3-hydroxyacyl-CoA dehydratase 4 | ![]() |
1 | 1 | |||||||
MIRT724470 | SMAD2 | SMAD family member 2 | ![]() |
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2 | 2 |
miRNA-Drug Resistance Associations | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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