miRTarBase - #MIRT516709


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pre-miRNA Information
pre-miRNA hsa-mir-3689e   
Genomic Coordinates chr9: 134850570 - 134850641
Description Homo sapiens miR-3689e stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-3689e
Sequence 7| UGUGAUAUCAUGGUUCCUGGGA |28
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs796680971 2 dbSNP
rs1260021280 4 dbSNP
rs951515835 6 dbSNP
rs1244734523 9 dbSNP
rs1286185090 10 dbSNP
rs922384128 14 dbSNP
rs1485140592 16 dbSNP
Putative Targets

Gene Information
Gene Symbol PIK3CG   
Synonyms PI3CG, PI3K, PI3Kgamma, PIK3, p110gamma, p120-PI3K
Description phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
Transcript NM_002649   
Expression
Putative miRNA Targets on PIK3CG
3'UTR of PIK3CG
(miRNA target sites are highlighted)		 
>PIK3CG|NM_002649|3'UTR
   1 TACTTTAGGCTAGAATCAAAAACAAGTTAGTGTTCTATGGTTTAAATTAGCATAGCAATCATCGAACTTGGATTTCAAAT
  81 GCAATAGACATTGTGAAAGCTGGCATTTCAGAAGTATAGCTCTTTTCCTACCTGAACTCTTCCCTGGAGAAAAGATGTTG
 161 GCATTGCTGATTGTTTGGTTAAGCAATGTCCAGTGCTAGGATTATTTGCAGGTTTGGTTTTTTCTCATTTGTCTGTGGCA
 241 TTGGAGAATATTCTCGGTTTAAACAGACTAATGACTTCCTTATTGTCCCTGATATTTTGACTATCTTACTATTGAGTGCT
 321 TCTGGAAATTCTTTGGAATAATTGATGACATCTATTTTCATCTGGGTTTAGTCTCAATTTTGGTTATCTTTGTGTTCCTC
 401 AAGCTCTTTAAAGAAAAAGATGTAATCGTTGTAACCTTTGTCTCATTCCTTAAATGATGCTTCCAAACATCTCCTTAGTG
 481 TCTGCAGGTGTTAGTGGTGTGCTAAAAGCAAGGAAAGCGAGTTAGTCTTTTCAGTGTCTTTTGCAATTCAATTCTTTTGT
 561 CATGTATAACTGAGACACACAAACACAGCAGGAGAAATCTAAACCGTTGTGCCTTGACCTTCCTCTGCTGGTCTTGTTCC
 641 AGGGTTATGAATATGAAAAAATAGAGATGAGACTTTTTGTGTCAACTCTGTCCACAAGAGTGAGTTATCTAGTATGATTA
 721 GTATAGCTTTCTCCAGCATGGCAGCAGGAAGTAACTACAGGGCCTCTTTTATGCCTGACATTTCTTCCCTTCCTTTTTCC
 801 CTGCCTCCCTTTTTCATCAATTGCGATGCTCCCACAACTCTTTACAGACTTGTGAAATCTTCAAGAACACCTTTACTCTA
 881 TAACTCAAAAATTAGTTGAAAAATAATTACTTCTCAAGGATTATTAGAATCTTAGGTACTTATTTGTAAAGATGTTTAGT
 961 GACTTTTTTTTCAAGTATCTTATTAAAGGAGGCATTCTAGAAAATATGAATTAGTTTCCAAATGCCTTAATTTTAAACTT
1041 TGGCCTGAACAGTTTTTTCTTTTTCTTAATGGAAGAAGATATTTAATATCTTAAAAATATTCCAAGTTAGGAAGAACACT
1121 ACTTGCCTTATCCATTTCCCATTTAAAGGACTTTTAAACTTTGACACATCCTTCAGATTTCCTGAAAATAATTGAAATAT
1201 CTTACTTTAAAAATATTTTCATCTCTGAAATATCTCGTTATTTATTGGAGGTATTGTTTAACCTTAGAGAGACCATTAAA
1281 TTATTTATAAAATATTTTGTAATTACCTGTAGCTAATACATTACATAGAAAAAAACTATGTTAACAGTGTCTCTGTTTAA
1361 GTATAATCAGATATAAATATATACTTAATTTTTTAATTTTAAAAATAGATACCTGTTTGACTTTGAGGTAGTCCAGACCT
1441 TTTCTTTTTTTTTTTTTTTTTAATGTGTGCAAAAGCCCAAAGGTTCCTAAGCCTGGCTGCAAAGAAGAATCAACAGGGAC
1521 ACTTTTTAAAAACACTCTTATCAGCCTGGGCAACACAGTGAGACTCCATCTCTTAAAAAAAAAATTAGCTGGGTATAGTG
1601 GTATGTGCCTGTAGTCCCAGGTACTCAGGAGGCTGAGGCAGGAGGATTGCCTGAGCCCAGGAGGTGGAAACTGCAGAGAG
1681 TCATGATCATGTCCTTACACTCCAGCCTGGATAACAGAGCGAGACCCTGTCTCAAAAAAATAAAATAAAAAATAAAAACA
1761 CCCTTGCCTGCGCTCCATTCCCAGGTTATAATTTAATTACTGTGGGATGAGACCCAGACATCAATATTTTTCTAGATTCT
1841 TCAGGTGATTCTAATTCACAGCCAGAGTTGGAAGCCCTGCGTGGCCTTTGAAGGTCTAGATGATTCTTCTTCCTTGCCCT
1921 TTGAGCTTTTCCCCATCTCACAGGTATCTAGAAAAAAACTCCTCTTCTTTGGCAACCTGTCCTTTTAAAATCACACTCTA
2001 CCCACCTGTACAGAAGACCATGCCCTATAATGAAATGTTTATTCCTATCTATAAATGGAGGATAAACATTTTGTGGCACT
2081 TCTGGACCAACTATTCCCTACTATTCTTTTGAAGAAAGGCAGGAAGAGTACTTTCTAATTCAGAAGAGGATGTTTTCACT
2161 ATTCTGATAAACAATAGCCAAGTTCAGACCTTGTACAGATTCTTTTTATTTGAATTGCTGAAATAATTTATTGATGATGA
2241 AAAAAAGATTAGAGAGGAATACATTTATATTTAGCTTATTGGCACATGTGCATACATATTTCCTCTTCAAATGAACCAGT
2321 TCTTTCATTTCATTATGCTAATATATATATATAACATATATATGCTAATATATATATAACATATATATGCTAATATATAT
2401 ATATCACACATATATATCACAGTTTTATATATATATATGTATGTGTGTGTGTATATATATATATATATATCACAGTTGGG
2481 CTTGATTCTTCCGTATTCCAAAGAGCATAATTTCAGTTCTATAGACTTATAGATAAATAAAAATCATCTTTGTGGGCTTC
2561 CTTCCTTTACTGTTCGCAGTGAATTACATGACGAACAACTTCTATACCTTTGAAAATGTTCTAGAACTAGAATCATCCTG
2641 CTACTGGGAACTACCCACAGCTCTATCTTCAATGCCAGGTGAAAACACAGATCACAAGTCAGATGAATCAGGCCAAAGCA
2721 ACTTTTATGTATATCTAGGACTGGCGACATAATTTGCAGAGCCCAGTGAACAGTGAAAATGCAGTCCCATCATTCAAAAA
2801 TTATTAAGAAATTCGAGATGGCAACAGCAGTTGTCACACCAAGCACAGTGCCCTTCTGAGCATGAGGCTCTGTGTGACTG
2881 CATGGGTCCATGAGACCAGCACTGTGTGGGTCTGAATGATGGCTTTGGTGTTCAGTTTAGCACACGCGGTCTACCACGTC
2961 TGCATGAGTGGTAAATGTAGTGCCTGGGTCAAAATGTTCCTTCTGTTCAAATCGAAATACCTCATCTCTATGGCTCTATG
3041 GCTGTACATTAGGACCTAGAACAGTGGCCCATTGCTCTTAGACTGGAACCATGTCCACTAAAATAAACCTAAGCAGATGT
3121 TGTAGACCTAGCCCCACAGGACTGCATTTAGCTGCTTCAGTGACACTTTGATGAAAGTATGGAGAAGTGGAGACATTATA
3201 GATAAAATATATCAATTCCCAGAGAAAACTCTTGACTTAAAAACTTAACTGTAGTAAATATATCTTTTTCAGGTGATGAA
3281 TTATTTTTTTAAAAAAGGTTACATATAGGAATTCTGCAGTATAATTTGGAGGCTATTAGTGCTATATTAATGGAAATTAA
3361 TTATTTTTTAAGTAAGTCCAAAAAATAATCTAGAAAGTAAGTTTCCAGAGCAAATCTGACCTAGCATTTGGTATGCTAGG
3441 CTCTGCTTTTCATGATTTTGAAATAAATCATAATTAGACTTAACAATATGGAGAAAATAAACTTGTATTTTTAAGTGTTC
3521 TGTTGGCTTATTTTCTGTTTCATCCAACTCAATAATTCTGATAAATAAATTTGGTTCTAGTTTGGTGCTTGAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' agGGUCCUUGGUACUAUAGUGu 5'
            |:|  |  :|| ||||||| 
Target 5' tgCTAATATATAT-ATATCACa 3'
 2388 - 2408 147.00 -8.90
2 
miRNA  3' aggguccuugGUACUAUAGUGu 5'
                    :|| ||||||| 
Target 5' tatatatataTAT-ATATCACa 3'
 2454 - 2474 143.00 -7.70
3 
miRNA  3' agGGUCC---UUGGUACUAUAGUGu 5'
            |||||   || ||  | ||||| 
Target 5' tgCCAGGTGAAAACA-CAGATCACa 3'
 2673 - 2696 127.00 -15.70
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30154794 10 COSMIC
COSN31510133 10 COSMIC
COSN31511307 11 COSMIC
COSN14250889 14 COSMIC
COSN30160234 14 COSMIC
COSN30187782 18 COSMIC
COSN31505794 33 COSMIC
COSN30146024 36 COSMIC
COSN30190010 49 COSMIC
COSN14250890 50 COSMIC
COSN14250892 65 COSMIC
COSN30504890 69 COSMIC
COSN31508512 88 COSMIC
COSN30122503 104 COSMIC
COSN23592960 137 COSMIC
COSN15127420 272 COSMIC
COSN17181632 373 COSMIC
COSN24623939 398 COSMIC
COSN19108980 645 COSMIC
COSN14453911 774 COSMIC
COSN15661602 887 COSMIC
COSN28009694 972 COSMIC
COSN32058318 1039 COSMIC
COSN16475269 1088 COSMIC
COSN32065287 1202 COSMIC
COSN28198101 1395 COSMIC
COSN26885611 1451 COSMIC
COSN28952601 1462 COSMIC
COSN2190513 1703 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs190257233 7 dbSNP
rs752158425 8 dbSNP
rs1490682005 9 dbSNP
rs755581938 14 dbSNP
rs865863969 18 dbSNP
rs765691755 19 dbSNP
rs849409 21 dbSNP
rs1160855307 23 dbSNP
rs1423667330 24 dbSNP
rs758879455 27 dbSNP
rs1419515764 28 dbSNP
rs1296517534 35 dbSNP
rs1367667537 36 dbSNP
rs140716866 38 dbSNP
rs747368933 39 dbSNP
rs371211843 41 dbSNP
rs1434145363 47 dbSNP
rs374552635 49 dbSNP
rs972612895 51 dbSNP
rs1349162508 56 dbSNP
rs918283382 59 dbSNP
rs570872249 61 dbSNP
rs1338018689 63 dbSNP
rs1330199986 64 dbSNP
rs1409539582 65 dbSNP
rs930991241 68 dbSNP
rs779411944 80 dbSNP
rs972554348 85 dbSNP
rs767481671 89 dbSNP
rs1287350515 119 dbSNP
rs1489502315 133 dbSNP
rs1165010774 142 dbSNP
rs1424921111 144 dbSNP
rs1412698266 164 dbSNP
rs927768621 170 dbSNP
rs1470903175 171 dbSNP
rs960613552 174 dbSNP
rs990735210 185 dbSNP
rs750722485 186 dbSNP
rs1270786627 187 dbSNP
rs1223020483 192 dbSNP
rs948756573 197 dbSNP
rs1289480832 214 dbSNP
rs1352958492 217 dbSNP
rs533502735 218 dbSNP
rs978764601 218 dbSNP
rs1348958319 227 dbSNP
rs1305327577 228 dbSNP
rs1469171005 246 dbSNP
rs934702112 254 dbSNP
rs3173908 256 dbSNP
rs565930791 257 dbSNP
rs1408119514 270 dbSNP
rs754583636 274 dbSNP
rs1158247877 276 dbSNP
rs934140433 289 dbSNP
rs1302254487 293 dbSNP
rs766305167 300 dbSNP
rs1050460811 304 dbSNP
rs534803148 312 dbSNP
rs1477602495 321 dbSNP
rs1390312060 323 dbSNP
rs145918727 326 dbSNP
rs1246291540 329 dbSNP
rs1387504392 343 dbSNP
rs1448740234 347 dbSNP
rs1010519895 348 dbSNP
rs753635314 355 dbSNP
rs1208256890 364 dbSNP
rs181503182 377 dbSNP
rs536672468 383 dbSNP
rs1028956897 395 dbSNP
rs953627846 399 dbSNP
rs987509706 407 dbSNP
rs1334115324 422 dbSNP
rs1220160203 424 dbSNP
rs1446098489 429 dbSNP
rs1005650777 446 dbSNP
rs1019435185 455 dbSNP
rs1016573205 461 dbSNP
rs569277615 469 dbSNP
rs556885160 471 dbSNP
rs849410 473 dbSNP
rs931211027 474 dbSNP
rs1413656343 475 dbSNP
rs1422802701 476 dbSNP
rs1189632256 477 dbSNP
rs984194010 484 dbSNP
rs74752528 485 dbSNP
rs1187973293 486 dbSNP
rs1463640318 489 dbSNP
rs1265491577 493 dbSNP
rs1211477393 495 dbSNP
rs1329268427 507 dbSNP
rs1311910307 519 dbSNP
rs184046093 520 dbSNP
rs1296479106 521 dbSNP
rs1432201327 534 dbSNP
rs1384397594 539 dbSNP
rs1303287241 544 dbSNP
rs849411 547 dbSNP
rs1247955320 555 dbSNP
rs1436764570 561 dbSNP
rs1410366226 581 dbSNP
rs748403933 583 dbSNP
rs1168226691 590 dbSNP
rs1239968156 594 dbSNP
rs777237739 596 dbSNP
rs1442644119 605 dbSNP
rs922667814 606 dbSNP
rs946213035 607 dbSNP
rs1483202298 611 dbSNP
rs1236273220 614 dbSNP
rs1162706549 616 dbSNP
rs1368902522 620 dbSNP
rs1273414337 624 dbSNP
rs1225728430 642 dbSNP
rs1459235501 655 dbSNP
rs1041857685 657 dbSNP
rs1360898931 663 dbSNP
rs541971513 668 dbSNP
rs1165265951 669 dbSNP
rs1395016497 678 dbSNP
rs1376850722 679 dbSNP
rs904777830 686 dbSNP
rs1049900598 688 dbSNP
rs1410156253 689 dbSNP
rs890049759 716 dbSNP
rs1307581111 720 dbSNP
rs941589569 725 dbSNP
rs1000452287 727 dbSNP
rs1394561330 736 dbSNP
rs141246394 746 dbSNP
rs1412198129 747 dbSNP
rs1423370854 747 dbSNP
rs1332066178 758 dbSNP
rs879162213 759 dbSNP
rs1179495358 764 dbSNP
rs896863954 765 dbSNP
rs1251557244 772 dbSNP
rs575497574 773 dbSNP
rs1008960561 780 dbSNP
rs746696638 818 dbSNP
rs530804025 821 dbSNP
rs1319432659 822 dbSNP
rs1309014598 825 dbSNP
rs12667819 826 dbSNP
rs968376561 827 dbSNP
rs1305940309 832 dbSNP
rs564533596 837 dbSNP
rs979413539 839 dbSNP
rs1025435838 855 dbSNP
rs1393115737 857 dbSNP
rs1294362713 865 dbSNP
rs952776415 879 dbSNP
rs1316868426 882 dbSNP
rs1457435525 887 dbSNP
rs1198746132 894 dbSNP
rs1030916392 895 dbSNP
rs1161924080 902 dbSNP
rs956054707 904 dbSNP
rs188446364 907 dbSNP
rs1302149843 913 dbSNP
rs926978836 921 dbSNP
rs1481653605 932 dbSNP
rs958339765 943 dbSNP
rs547113245 950 dbSNP
rs1487181259 954 dbSNP
rs1261988939 955 dbSNP
rs58881507 960 dbSNP
rs917013464 961 dbSNP
rs986041575 964 dbSNP
rs1286431031 966 dbSNP
rs1225066396 975 dbSNP
rs945741714 976 dbSNP
rs1302161122 986 dbSNP
rs181127085 992 dbSNP
rs1371576747 1001 dbSNP
rs1322633952 1004 dbSNP
rs926137400 1008 dbSNP
rs1465244201 1011 dbSNP
rs1388523338 1013 dbSNP
rs1038648527 1029 dbSNP
rs1467868086 1048 dbSNP
rs1378583597 1051 dbSNP
rs1171481569 1054 dbSNP
rs749602141 1055 dbSNP
rs1431083792 1067 dbSNP
rs1468278310 1086 dbSNP
rs929664954 1092 dbSNP
rs1188610645 1093 dbSNP
rs1282829491 1103 dbSNP
rs1050682177 1111 dbSNP
rs1403488304 1116 dbSNP
rs1056034178 1117 dbSNP
rs528300689 1118 dbSNP
rs1255178041 1119 dbSNP
rs1230874014 1126 dbSNP
rs548379097 1135 dbSNP
rs1300155019 1136 dbSNP
rs1293811952 1137 dbSNP
rs1364590979 1140 dbSNP
rs1319056446 1141 dbSNP
rs889343237 1145 dbSNP
rs1339456023 1155 dbSNP
rs1008867114 1170 dbSNP
rs749816495 1172 dbSNP
rs1464894933 1178 dbSNP
rs568381685 1184 dbSNP
rs1047017 1191 dbSNP
rs1047018 1192 dbSNP
rs1391578609 1193 dbSNP
rs1218938587 1201 dbSNP
rs897915549 1202 dbSNP
rs879698874 1222 dbSNP
rs1245680398 1234 dbSNP
rs1189083003 1237 dbSNP
rs771475481 1238 dbSNP
rs903720006 1245 dbSNP
rs1198490005 1246 dbSNP
rs1341239534 1256 dbSNP
rs1276990756 1266 dbSNP
rs1047019 1270 dbSNP
rs1229417881 1274 dbSNP
rs1001094723 1277 dbSNP
rs537388236 1297 dbSNP
rs993593863 1298 dbSNP
rs550594419 1320 dbSNP
rs952562178 1326 dbSNP
rs1334144616 1329 dbSNP
rs1484165438 1329 dbSNP
rs1203174945 1337 dbSNP
rs1394607623 1339 dbSNP
rs1005904381 1340 dbSNP
rs567579257 1343 dbSNP
rs1372798307 1347 dbSNP
rs1034284141 1353 dbSNP
rs1308195094 1355 dbSNP
rs956586717 1367 dbSNP
rs958581333 1380 dbSNP
rs1388009163 1389 dbSNP
rs1164459891 1394 dbSNP
rs992500123 1397 dbSNP
rs534570673 1403 dbSNP
rs967567988 1413 dbSNP
rs1194715991 1416 dbSNP
rs977186396 1416 dbSNP
rs1047020 1438 dbSNP
rs1185373723 1439 dbSNP
rs1483876309 1440 dbSNP
rs926138809 1443 dbSNP
rs1220888250 1445 dbSNP
rs1230081768 1445 dbSNP
rs1357178744 1445 dbSNP
rs199687602 1445 dbSNP
rs571080689 1445 dbSNP
rs79626855 1446 dbSNP
rs1047021 1447 dbSNP
rs1175391105 1447 dbSNP
rs1378735799 1448 dbSNP
rs1289371027 1449 dbSNP
rs955648527 1449 dbSNP
rs1467972918 1450 dbSNP
rs1409642267 1451 dbSNP
rs71156345 1462 dbSNP
rs1183587068 1463 dbSNP
rs1360361800 1466 dbSNP
rs35957952 1467 dbSNP
rs1400965294 1468 dbSNP
rs1299694952 1470 dbSNP
rs985603348 1472 dbSNP
rs1412707595 1476 dbSNP
rs911286492 1481 dbSNP
rs1471517226 1483 dbSNP
rs570464754 1484 dbSNP
rs1231348521 1500 dbSNP
rs1224050350 1501 dbSNP
rs1452189988 1502 dbSNP
rs1289219881 1504 dbSNP
rs1211969260 1515 dbSNP
rs962937995 1519 dbSNP
rs974626288 1523 dbSNP
rs1228115098 1525 dbSNP
rs918857797 1532 dbSNP
rs1276187145 1549 dbSNP
rs1436768388 1555 dbSNP
rs930199663 1565 dbSNP
rs539020752 1570 dbSNP
rs1321012937 1575 dbSNP
rs398086040 1575 dbSNP
rs78567555 1575 dbSNP
rs200624866 1576 dbSNP
rs1051003212 1586 dbSNP
rs866119147 1595 dbSNP
rs1427021973 1604 dbSNP
rs1191613275 1605 dbSNP
rs1301290550 1613 dbSNP
rs1246385164 1614 dbSNP
rs1191802651 1618 dbSNP
rs910811949 1619 dbSNP
rs1044850295 1621 dbSNP
rs1313887385 1622 dbSNP
rs1208656650 1632 dbSNP
rs10216210 1638 dbSNP
rs1040390727 1639 dbSNP
rs1281153498 1640 dbSNP
rs897821043 1646 dbSNP
rs1343819854 1657 dbSNP
rs185215518 1658 dbSNP
rs1300872481 1668 dbSNP
rs1436588636 1675 dbSNP
rs1000724433 1676 dbSNP
rs994016382 1681 dbSNP
rs535668296 1688 dbSNP
rs892398257 1690 dbSNP
rs1360886967 1691 dbSNP
rs114594129 1695 dbSNP
rs1413748475 1700 dbSNP
rs1005395428 1701 dbSNP
rs575727394 1705 dbSNP
rs1172040946 1721 dbSNP
rs774978984 1722 dbSNP
rs894439185 1726 dbSNP
rs1188074394 1729 dbSNP
rs1239766184 1734 dbSNP
rs1485176793 1734 dbSNP
rs1211240979 1737 dbSNP
rs1018381375 1738 dbSNP
rs544936583 1741 dbSNP
rs1230175779 1743 dbSNP
rs564616975 1752 dbSNP
rs538494550 1762 dbSNP
rs1487593617 1765 dbSNP
rs1014174082 1767 dbSNP
rs1212328757 1770 dbSNP
rs138772193 1772 dbSNP
rs1446965224 1773 dbSNP
rs1373396649 1785 dbSNP
rs1311232502 1795 dbSNP
rs1025732954 1800 dbSNP
rs1391090653 1801 dbSNP
rs540217447 1807 dbSNP
rs560592475 1808 dbSNP
rs1268221637 1821 dbSNP
rs1032776091 1828 dbSNP
rs1182986666 1833 dbSNP
rs1434963426 1835 dbSNP
rs992408229 1840 dbSNP
rs1207819308 1841 dbSNP
rs767616731 1844 dbSNP
rs1273526943 1846 dbSNP
rs1201763032 1852 dbSNP
rs539904057 1854 dbSNP
rs1420731327 1860 dbSNP
rs190751756 1867 dbSNP
rs561908218 1869 dbSNP
rs986264634 1876 dbSNP
rs1371374602 1881 dbSNP
rs542025340 1882 dbSNP
rs980823183 1885 dbSNP
rs1435227077 1889 dbSNP
rs1293748538 1895 dbSNP
rs879083856 1901 dbSNP
rs944992892 1906 dbSNP
rs976290818 1907 dbSNP
rs1165641066 1942 dbSNP
rs1389143332 1952 dbSNP
rs1416382890 1960 dbSNP
rs1184752144 1962 dbSNP
rs1308485701 1968 dbSNP
rs925069774 1974 dbSNP
rs1250562362 1977 dbSNP
rs1175122986 1984 dbSNP
rs919281838 1986 dbSNP
rs1489141479 1989 dbSNP
rs1265503016 1991 dbSNP
rs1220277502 1997 dbSNP
rs1332550146 2000 dbSNP
rs1269994155 2001 dbSNP
rs1242064702 2002 dbSNP
rs1289240071 2003 dbSNP
rs929339716 2021 dbSNP
rs182584883 2023 dbSNP
rs1221182232 2024 dbSNP
rs1247482714 2026 dbSNP
rs1370086115 2028 dbSNP
rs561601070 2037 dbSNP
rs1294153975 2043 dbSNP
rs186984831 2049 dbSNP
rs79439413 2056 dbSNP
rs1238128055 2062 dbSNP
rs1440789886 2066 dbSNP
rs1458035205 2077 dbSNP
rs1363595742 2078 dbSNP
rs1055672475 2080 dbSNP
rs1434541097 2084 dbSNP
rs10215499 2090 dbSNP
rs1190101351 2094 dbSNP
rs1405127356 2101 dbSNP
rs1165090656 2107 dbSNP
rs1014205022 2108 dbSNP
rs760996504 2119 dbSNP
rs1209284127 2131 dbSNP
rs1328161792 2141 dbSNP
rs1024248342 2150 dbSNP
rs1258732186 2160 dbSNP
rs1051708920 2167 dbSNP
rs1314138159 2174 dbSNP
rs1302268656 2175 dbSNP
rs1440212039 2180 dbSNP
rs113143966 2195 dbSNP
rs191898262 2197 dbSNP
rs1436445778 2203 dbSNP
rs1033051478 2207 dbSNP
rs1384958331 2212 dbSNP
rs1157163273 2224 dbSNP
rs766647915 2229 dbSNP
rs1018662868 2230 dbSNP
rs1172664159 2235 dbSNP
rs1377557048 2240 dbSNP
rs1451965734 2240 dbSNP
rs1188710741 2251 dbSNP
rs1464360659 2256 dbSNP
rs1259630858 2259 dbSNP
rs149379472 2261 dbSNP
rs1483470771 2279 dbSNP
rs1256741264 2281 dbSNP
rs1017756437 2282 dbSNP
rs555041962 2284 dbSNP
rs1299912970 2287 dbSNP
rs753687309 2288 dbSNP
rs1229283299 2289 dbSNP
rs1228647781 2290 dbSNP
rs1290903915 2292 dbSNP
rs1323683071 2293 dbSNP
rs1326337295 2297 dbSNP
rs1316872541 2301 dbSNP
rs1398115203 2316 dbSNP
rs976196077 2317 dbSNP
rs1257430657 2325 dbSNP
rs1311841409 2327 dbSNP
rs1432468251 2334 dbSNP
rs1478582041 2334 dbSNP
rs919527526 2340 dbSNP
rs1168339676 2341 dbSNP
rs1168646429 2341 dbSNP
rs992269379 2341 dbSNP
rs769898926 2343 dbSNP
rs569475886 2346 dbSNP
rs929511923 2347 dbSNP
rs1424115841 2351 dbSNP
rs1201139195 2353 dbSNP
rs1256523730 2353 dbSNP
rs984850744 2355 dbSNP
rs1277096788 2356 dbSNP
rs1205900990 2358 dbSNP
rs909200141 2361 dbSNP
rs1236207812 2363 dbSNP
rs1268870300 2365 dbSNP
rs1341655996 2368 dbSNP
rs201378327 2368 dbSNP
rs970016975 2368 dbSNP
rs576591267 2375 dbSNP
rs1182755006 2376 dbSNP
rs1413371735 2376 dbSNP
rs1308289976 2377 dbSNP
rs199500402 2377 dbSNP
rs137961342 2378 dbSNP
rs6150272 2378 dbSNP
rs1415525131 2380 dbSNP
rs1164552122 2381 dbSNP
rs980472893 2381 dbSNP
rs1417128763 2382 dbSNP
rs924903364 2383 dbSNP
rs936320603 2393 dbSNP
rs987924496 2393 dbSNP
rs1169507330 2395 dbSNP
rs1182806830 2397 dbSNP
rs1400462633 2402 dbSNP
rs200689019 2403 dbSNP
rs1466708555 2404 dbSNP
rs1332154940 2405 dbSNP
rs1437259983 2412 dbSNP
rs913639345 2413 dbSNP
rs1358468339 2422 dbSNP
rs1336074604 2423 dbSNP
rs1352715379 2426 dbSNP
rs933162659 2426 dbSNP
rs1055197917 2428 dbSNP
rs538015874 2436 dbSNP
rs889049845 2436 dbSNP
rs201657679 2440 dbSNP
rs1333690194 2442 dbSNP
rs558432127 2442 dbSNP
rs1386896040 2446 dbSNP
rs1393577592 2450 dbSNP
rs142177460 2452 dbSNP
rs776614128 2452 dbSNP
rs896549028 2452 dbSNP
rs578168140 2454 dbSNP
rs1381625565 2459 dbSNP
rs1212378530 2468 dbSNP
rs1285387864 2470 dbSNP
rs540649118 2470 dbSNP
rs554244545 2472 dbSNP
rs1387016999 2473 dbSNP
rs574063222 2477 dbSNP
rs1318756094 2479 dbSNP
rs1047158303 2482 dbSNP
rs1389374916 2485 dbSNP
rs1317340191 2491 dbSNP
rs999175192 2493 dbSNP
rs1277144863 2494 dbSNP
rs887170852 2509 dbSNP
rs1054161649 2510 dbSNP
rs1191897647 2521 dbSNP
rs11766675 2522 dbSNP
rs1025530989 2525 dbSNP
rs182896438 2531 dbSNP
rs374117564 2548 dbSNP
rs544046905 2551 dbSNP
rs1280222129 2554 dbSNP
rs1246183861 2557 dbSNP
rs564420426 2561 dbSNP
rs965737513 2576 dbSNP
rs117701040 2577 dbSNP
rs1192543731 2579 dbSNP
rs1032588862 2583 dbSNP
rs1362550401 2589 dbSNP
rs1026858214 2593 dbSNP
rs1428298658 2594 dbSNP
rs951033346 2597 dbSNP
rs985435419 2605 dbSNP
rs909239800 2606 dbSNP
rs1478537026 2612 dbSNP
rs1435564649 2620 dbSNP
rs1375110172 2623 dbSNP
rs1170247741 2627 dbSNP
rs1424394187 2649 dbSNP
rs959380728 2652 dbSNP
rs990791576 2656 dbSNP
rs1414906428 2659 dbSNP
rs957721579 2666 dbSNP
rs368006329 2674 dbSNP
rs1336089169 2679 dbSNP
rs987785827 2689 dbSNP
rs1474599399 2693 dbSNP
rs918014378 2697 dbSNP
rs1358453198 2698 dbSNP
rs566177682 2701 dbSNP
rs1399142982 2705 dbSNP
rs1485124188 2709 dbSNP
rs1045607580 2723 dbSNP
rs1277813325 2726 dbSNP
rs187252270 2729 dbSNP
rs1307569015 2732 dbSNP
rs1297864046 2733 dbSNP
rs867375769 2735 dbSNP
rs143106811 2737 dbSNP
rs1381330272 2742 dbSNP
rs954413410 2746 dbSNP
rs934622835 2750 dbSNP
rs910338221 2763 dbSNP
rs943212698 2765 dbSNP
rs1054761073 2767 dbSNP
rs1273082469 2769 dbSNP
rs774698366 2772 dbSNP
rs893028162 2773 dbSNP
rs1007191963 2786 dbSNP
rs1408712342 2795 dbSNP
rs1344392086 2802 dbSNP
rs1416645669 2803 dbSNP
rs1038638352 2804 dbSNP
rs1189071276 2806 dbSNP
rs568814349 2815 dbSNP
rs1281319100 2816 dbSNP
rs758229103 2818 dbSNP
rs1480786200 2819 dbSNP
rs1216288686 2821 dbSNP
rs1201872567 2826 dbSNP
rs1263491091 2836 dbSNP
rs1047022398 2837 dbSNP
rs1026514107 2838 dbSNP
rs1273761049 2840 dbSNP
rs950931617 2841 dbSNP
rs1332419497 2848 dbSNP
rs887200560 2851 dbSNP
rs1013586069 2854 dbSNP
rs1046475271 2861 dbSNP
rs905394831 2862 dbSNP
rs1440179047 2864 dbSNP
rs1002365351 2868 dbSNP
rs1166332210 2869 dbSNP
rs1489036024 2871 dbSNP
rs1033030444 2881 dbSNP
rs1416121226 2881 dbSNP
rs1196140803 2885 dbSNP
rs538456131 2887 dbSNP
rs1006367217 2891 dbSNP
rs1016941750 2897 dbSNP
rs959578749 2899 dbSNP
rs138873759 2905 dbSNP
rs574017772 2906 dbSNP
rs917921975 2910 dbSNP
rs751014720 2912 dbSNP
rs756909457 2914 dbSNP
rs978569173 2920 dbSNP
rs1467129519 2929 dbSNP
rs1269782850 2939 dbSNP
rs1239555105 2941 dbSNP
rs924491058 2946 dbSNP
rs934506816 2947 dbSNP
rs1221146460 2948 dbSNP
rs1054264817 2949 dbSNP
rs1440809331 2954 dbSNP
rs1290975151 2958 dbSNP
rs964930823 2958 dbSNP
rs973238798 2959 dbSNP
rs1362818234 2967 dbSNP
rs1156499035 2978 dbSNP
rs920526225 2987 dbSNP
rs1395149265 2996 dbSNP
rs1192537937 3000 dbSNP
rs929191846 3014 dbSNP
rs1047053282 3015 dbSNP
rs1205456940 3021 dbSNP
rs914496011 3031 dbSNP
rs780887852 3034 dbSNP
rs1213886654 3039 dbSNP
rs1321810320 3041 dbSNP
rs908590817 3042 dbSNP
rs1369360721 3045 dbSNP
rs1298412986 3060 dbSNP
rs1383062917 3063 dbSNP
rs1384717564 3070 dbSNP
rs1287546941 3072 dbSNP
rs1038712850 3076 dbSNP
rs1436195573 3083 dbSNP
rs1375726887 3093 dbSNP
rs901506358 3111 dbSNP
rs933110998 3113 dbSNP
rs1047955424 3115 dbSNP
rs886162812 3116 dbSNP
rs1374688511 3123 dbSNP
rs949407775 3128 dbSNP
rs1006809970 3131 dbSNP
rs1427904233 3136 dbSNP
rs1016393463 3145 dbSNP
rs895439785 3153 dbSNP
rs1259389317 3156 dbSNP
rs1183417417 3167 dbSNP
rs1486762341 3175 dbSNP
rs1437238849 3178 dbSNP
rs1210201004 3183 dbSNP
rs905259848 3186 dbSNP
rs1253537745 3188 dbSNP
rs1228776556 3196 dbSNP
rs1326426981 3200 dbSNP
rs1306305038 3204 dbSNP
rs1012495693 3210 dbSNP
rs745491878 3212 dbSNP
rs1355646791 3218 dbSNP
rs1025009480 3235 dbSNP
rs142879814 3246 dbSNP
rs970698404 3268 dbSNP
rs534528410 3271 dbSNP
rs1287109352 3274 dbSNP
rs116947423 3279 dbSNP
rs1189733639 3284 dbSNP
rs1371325903 3284 dbSNP
rs1475416273 3291 dbSNP
rs772130347 3291 dbSNP
rs1207761297 3292 dbSNP
rs1288675492 3295 dbSNP
rs540981364 3299 dbSNP
rs890158721 3304 dbSNP
rs1008549467 3305 dbSNP
rs958111945 3306 dbSNP
rs964465734 3322 dbSNP
rs990391041 3323 dbSNP
rs1179174095 3330 dbSNP
rs1235448619 3332 dbSNP
rs574089616 3336 dbSNP
rs1027406003 3340 dbSNP
rs1412508395 3342 dbSNP
rs914402822 3345 dbSNP
rs35267393 3352 dbSNP
rs542994616 3360 dbSNP
rs983368973 3364 dbSNP
rs559527422 3374 dbSNP
rs1161718122 3375 dbSNP
rs868317308 3385 dbSNP
rs556637987 3386 dbSNP
rs1406046559 3393 dbSNP
rs750295140 3396 dbSNP
rs1167056701 3397 dbSNP
rs1327944858 3398 dbSNP
rs758382160 3398 dbSNP
rs1461726536 3399 dbSNP
rs1416869296 3412 dbSNP
rs949439715 3420 dbSNP
rs1471929896 3425 dbSNP
rs1365822008 3426 dbSNP
rs1375339001 3426 dbSNP
rs73409297 3431 dbSNP
rs932996241 3432 dbSNP
rs1272945774 3433 dbSNP
rs1227024795 3456 dbSNP
rs1047358015 3465 dbSNP
rs370855889 3473 dbSNP
rs766407996 3478 dbSNP
rs1237657961 3480 dbSNP
rs1333501549 3492 dbSNP
rs1327389790 3494 dbSNP
rs1441506563 3497 dbSNP
rs1243032816 3500 dbSNP
rs1283268983 3508 dbSNP
rs941788352 3524 dbSNP
rs1215023682 3528 dbSNP
rs1255677620 3533 dbSNP
rs1402244852 3536 dbSNP
rs1410350467 3548 dbSNP
rs1456919308 3553 dbSNP
rs1469644520 3562 dbSNP
rs1378523379 3578 dbSNP
rs1037908361 3581 dbSNP
rs1199243173 3583 dbSNP
rs751022216 3586 dbSNP
rs895302693 3592 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Hela
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1048187. RNA binding protein: AGO2. Condition:Hela_AGO2_CLIP_control ...

- Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al., 2013, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' aggguccuuggUACUAUAGUGu 5'
                     || ||||||| 
Target 5' -----------AU-AUAUCACa 3'
 		1 - 10
Article - Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al.
- Cell, 2013
The induction of pluripotency or trans-differentiation of one cell type to another can be accomplished with cell-lineage-specific transcription factors. Here, we report that repression of a single RNA binding polypyrimidine-tract-binding (PTB) protein, which occurs during normal brain development via the action of miR-124, is sufficient to induce trans-differentiation of fibroblasts into functional neurons. Besides its traditional role in regulated splicing, we show that PTB has a previously undocumented function in the regulation of microRNA functions, suppressing or enhancing microRNA targeting by competitive binding on target mRNA or altering local RNA secondary structure. A key event during neuronal induction is the relief of PTB-mediated blockage of microRNA action on multiple components of the REST complex, thereby derepressing a large array of neuronal genes, including miR-124 and multiple neuronal-specific transcription factors, in nonneuronal cells. This converts a negative feedback loop to a positive one to elicit cellular reprogramming to the neuronal lineage.
LinkOut: [PMID: 23313552]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 5294.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM1065667. RNA binding protein: AGO1. Condition:4-thiouridine ...

- Memczak S; Jens M; Elefsinioti A; Torti F; et al., 2013, Nature.

Article - Memczak S; Jens M; Elefsinioti A; Torti F; et al.
- Nature, 2013
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.
LinkOut: [PMID: 23446348]
CLIP-seq Support 1 for dataset GSM1048187
Method / RBP HITS-CLIP / AGO2
Cell line / Condition Hela / Hela_AGO2_CLIP_control
Location of target site ENST00000359195.3 | 3UTR | AUAUAUCACAGUUUUAUAUAUAUAUAUGUAU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23313552 / GSE42701
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1065667
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / 4-thiouridine, ML_MM_6
Location of target site ENST00000359195.3 | 3UTR | GUGUGUGUGUAUAUAUAUAUAUAUAUAUC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
45 hsa-miR-3689e Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT112233 MDM4 MDM4, p53 regulator 2 2
MIRT188658 FAM76A family with sequence similarity 76 member A 2 2
MIRT200913 ZNF264 zinc finger protein 264 2 4
MIRT210597 KBTBD8 kelch repeat and BTB domain containing 8 2 6
MIRT299209 CSRNP3 cysteine and serine rich nuclear protein 3 2 2
MIRT317526 SLC39A7 solute carrier family 39 member 7 2 2
MIRT355852 SGMS2 sphingomyelin synthase 2 2 4
MIRT443050 THRB thyroid hormone receptor beta 2 2
MIRT446629 SDC3 syndecan 3 2 2
MIRT449407 TRIM5 tripartite motif containing 5 2 2
MIRT463559 ZBTB39 zinc finger and BTB domain containing 39 2 6
MIRT465701 TNFAIP1 TNF alpha induced protein 1 2 2
MIRT472686 MYCBP MYC binding protein 2 4
MIRT493285 LNPEP leucyl and cystinyl aminopeptidase 2 2
MIRT499336 RAB25 RAB25, member RAS oncogene family 2 2
MIRT501721 OVOL1 ovo like transcriptional repressor 1 2 2
MIRT507975 BCL2L13 BCL2 like 13 2 4
MIRT511809 HDGF heparin binding growth factor 2 6
MIRT516709 PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma 2 4
MIRT527851 SMOC1 SPARC related modular calcium binding 1 2 2
MIRT531284 SLC7A7 solute carrier family 7 member 7 2 2
MIRT531892 INVS inversin 2 8
MIRT536805 HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 2 2
MIRT537805 EFNB2 ephrin B2 2 4
MIRT544333 LPGAT1 lysophosphatidylglycerol acyltransferase 1 2 2
MIRT547140 PGM3 phosphoglucomutase 3 2 2
MIRT547427 MED4 mediator complex subunit 4 2 2
MIRT563352 ZNF181 zinc finger protein 181 2 2
MIRT564847 ZBED3 zinc finger BED-type containing 3 2 2
MIRT566424 PIGA phosphatidylinositol glycan anchor biosynthesis class A 2 2
MIRT572510 KIAA0232 KIAA0232 2 2
MIRT574680 HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 2 2
MIRT608818 ONECUT3 one cut homeobox 3 2 6
MIRT608884 CLIC6 chloride intracellular channel 6 2 2
MIRT608957 GIMAP1 GTPase, IMAP family member 1 2 4
MIRT609010 HPS3 HPS3, biogenesis of lysosomal organelles complex 2 subunit 1 2 2
MIRT641429 SCUBE3 signal peptide, CUB domain and EGF like domain containing 3 2 2
MIRT661839 ZNF587B zinc finger protein 587B 2 2
MIRT690649 RPF2 ribosome production factor 2 homolog 2 2
MIRT704617 CLIP1 CAP-Gly domain containing linker protein 1 2 2
MIRT708712 PTPLAD2 3-hydroxyacyl-CoA dehydratase 4 1 1
MIRT710661 CSTF2T cleavage stimulation factor subunit 2 tau variant 2 2
MIRT711258 TPCN2 two pore segment channel 2 2 2
MIRT714647 FSTL1 follistatin like 1 2 2
MIRT718516 COL19A1 collagen type XIX alpha 1 chain 2 2

Error report submission