miRTarBase - #MIRT517204


—
pre-miRNA Information
pre-miRNA hsa-mir-4732   
Genomic Coordinates chr17: 28861655 - 28861730
Description Homo sapiens miR-4732 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4732-5p
Sequence 9| UGUAGAGCAGGGAGCAGGAAGCU |31
Evidence Experimental
Experiments Illumina
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 19 17 - 28861704 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1217937677 2 dbSNP
rs758352089 5 dbSNP
rs1043420842 7 dbSNP
rs1282565841 10 dbSNP
rs1221758243 12 dbSNP
rs1380889672 13 dbSNP
rs1284341041 15 dbSNP
rs1413647390 16 dbSNP
rs762363998 18 dbSNP
rs1352947256 22 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol OTUD6A   
Synonyms DUBA2, HSHIN6
Description OTU deubiquitinase 6A
Transcript NM_207320   
Expression
Putative miRNA Targets on OTUD6A
3'UTR of OTUD6A
(miRNA target sites are highlighted)		 
>OTUD6A|NM_207320|3'UTR
   1 GCCCCAAGGCGCTGAGCAGCCCCGGGAAACTGTCGCCGTCGCCGCATCTCCTCAGTAGGCTCAGTTTATTTTCCCCTTTT
  81 GCTTTTCTCTGTTTTTCTTTTCCTTCCTTTTAATCAAAACTACCCGCCCCCGCCCCGCCCCCGCTTTCCTAACCTTGCTG
 161 CTTTCACAGGGTGGGAAACGAAATTCGAGGGAAATTCCCCGGAAATATGAGGGAAATCTCTGCATTGCACCACCAGAGGG
 241 GCATAAATTTGAAAGTTCTAACCTCTTCTTGCCCTTAAGGGTCTTTTACCTCCCTCACCAACTAAGATTTGGTCATGTTG
 321 CGTATAACTTCACCACAAAAATGGAAATATTGGCCGGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCG
 401 AGGCGGGCGGATCACGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCCACCTCTACAAAAAATACAAA
 481 AATTAGCCGGGCGTGGTGGCAGGCACCTGTAGTCCCAGATACTCGGGAGGCTAAGGCAGGAGAATCGCTTGACGGGAAGC
 561 GGAGGTTGCAGTGAGCCGAGATCGTGCCTTTGCACTCCAGCGTGGAAGACAGTGAGACTCCGTCTCAAAAAAATGAAAAA
 641 TTAGCCAGGCAGGTTGGCGGGGGCCTGTAATCCTAGCTACTTGGGGTGCTGAGGCAGGAGAATCAACTGAACCCGGGAGG
 721 CGGAGGCTGCAGTGGGCCGGGATCGTACTACTGCACTCCAGCATGGAAGACAGCGAGACTCCGTCTCC
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' ucGAAGGA--CGAGGGACGAGA-UGu 5'
            :|||||   ||: |||||:| || 
Target 5' gcTTTCCTAACCTTGCTGCTTTCACa 3'
 143 - 168 123.00 -18.20
2 
miRNA  3' ucgaaggacgagggacGAGAUGu 5'
                          |||||| 
Target 5' catggtgaaaccccacCTCTACa 3'
 447 - 469 120.00 -13.30
3 
miRNA  3' ucgAAGGACGAGGG----ACGAGAUGu 5'
             ||: | :||||    ||||:| | 
Target 5' cagTTTATTTTCCCCTTTTGCTTTTCt 3'
 62 - 88 114.00 -12.12
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs749626292 2 dbSNP
rs775191822 5 dbSNP
rs748831189 8 dbSNP
rs372543033 11 dbSNP
rs199939141 12 dbSNP
rs1359175073 13 dbSNP
rs1046310372 14 dbSNP
rs761722209 15 dbSNP
rs753581919 20 dbSNP
rs767539927 23 dbSNP
rs1240578432 24 dbSNP
rs773350885 25 dbSNP
rs766313181 26 dbSNP
rs1199758229 30 dbSNP
rs753958994 31 dbSNP
rs755118041 35 dbSNP
rs902989065 36 dbSNP
rs1237775186 41 dbSNP
rs1440592204 45 dbSNP
rs1333251724 47 dbSNP
rs1184289189 51 dbSNP
rs1476609724 56 dbSNP
rs757051283 90 dbSNP
rs1193372195 92 dbSNP
rs907458480 92 dbSNP
rs1004379444 111 dbSNP
rs1015563980 112 dbSNP
rs999206241 118 dbSNP
rs1407346173 123 dbSNP
rs986586515 123 dbSNP
rs1035594427 126 dbSNP
rs1451051978 126 dbSNP
rs1273658900 128 dbSNP
rs960355231 132 dbSNP
rs764890227 136 dbSNP
rs1012912563 137 dbSNP
rs1223890426 138 dbSNP
rs1347011528 139 dbSNP
rs1028433532 143 dbSNP
rs1435153986 144 dbSNP
rs1335789852 145 dbSNP
rs1330272429 160 dbSNP
rs1412180896 170 dbSNP
rs1398725236 171 dbSNP
rs1170500509 181 dbSNP
rs1456697528 187 dbSNP
rs1431737032 191 dbSNP
rs1023354765 193 dbSNP
rs963433961 198 dbSNP
rs973437950 201 dbSNP
rs753943592 202 dbSNP
rs950874458 218 dbSNP
rs186073514 223 dbSNP
rs912136798 239 dbSNP
rs1324829603 247 dbSNP
rs1204070348 253 dbSNP
rs1329045449 263 dbSNP
rs879082502 264 dbSNP
rs1218317139 269 dbSNP
rs1350919782 270 dbSNP
rs1280845242 275 dbSNP
rs924509585 282 dbSNP
rs1039372628 312 dbSNP
rs1375338937 313 dbSNP
rs920906182 317 dbSNP
rs758202225 319 dbSNP
rs778849345 323 dbSNP
rs753317883 326 dbSNP
rs1349312987 337 dbSNP
rs1408976018 351 dbSNP
rs1160377309 354 dbSNP
rs1227105054 357 dbSNP
rs1275524381 361 dbSNP
rs903041927 363 dbSNP
rs998696577 372 dbSNP
rs779979712 374 dbSNP
rs1057429253 386 dbSNP
rs1184082154 396 dbSNP
rs895741511 398 dbSNP
rs1462570465 400 dbSNP
rs1213402231 401 dbSNP
rs1013211035 403 dbSNP
rs1447291204 405 dbSNP
rs1285840480 408 dbSNP
rs1288138489 409 dbSNP
rs1439816310 410 dbSNP
rs1022940286 416 dbSNP
rs963322091 417 dbSNP
rs1385598397 418 dbSNP
rs867348184 422 dbSNP
rs1232390087 426 dbSNP
rs1346024970 429 dbSNP
rs1471615034 430 dbSNP
rs1179964353 431 dbSNP
rs1417967824 434 dbSNP
rs1026340985 438 dbSNP
rs950926736 443 dbSNP
rs1379802759 445 dbSNP
rs987663396 449 dbSNP
rs1446436717 451 dbSNP
rs912005871 454 dbSNP
rs1411534412 456 dbSNP
rs1181077642 457 dbSNP
rs1419881159 458 dbSNP
rs1243511929 462 dbSNP
rs965007579 463 dbSNP
rs1162477266 470 dbSNP
rs975369661 483 dbSNP
rs1224064693 488 dbSNP
rs1362226062 490 dbSNP
rs1311129190 491 dbSNP
rs747078346 492 dbSNP
rs1363044089 494 dbSNP
rs1272257425 502 dbSNP
rs1329045142 505 dbSNP
rs1360115956 506 dbSNP
rs1303910504 510 dbSNP
rs920959624 519 dbSNP
rs948438617 520 dbSNP
rs1163929422 521 dbSNP
rs189793582 526 dbSNP
rs1191211707 534 dbSNP
rs781361623 538 dbSNP
rs1407406768 539 dbSNP
rs1200969676 540 dbSNP
rs924348318 548 dbSNP
rs1356712066 549 dbSNP
rs1221531009 550 dbSNP
rs1037276343 554 dbSNP
rs934372321 555 dbSNP
rs1340127778 557 dbSNP
rs1264116743 566 dbSNP
rs181416518 578 dbSNP
rs898734621 579 dbSNP
rs770080373 584 dbSNP
rs1462480025 602 dbSNP
rs1028736394 603 dbSNP
rs1196611461 604 dbSNP
rs1056968618 615 dbSNP
rs1168276355 616 dbSNP
rs895616368 622 dbSNP
rs773412625 624 dbSNP
rs1008689397 627 dbSNP
rs1429579962 627 dbSNP
rs889886216 627 dbSNP
rs1213175484 632 dbSNP
rs1266113086 633 dbSNP
rs948679366 636 dbSNP
rs1177260106 637 dbSNP
rs1481283360 654 dbSNP
rs1018797979 659 dbSNP
rs1285532008 660 dbSNP
rs749670958 666 dbSNP
rs1475533975 677 dbSNP
rs899198252 682 dbSNP
rs1235754546 685 dbSNP
rs1310647176 686 dbSNP
rs1300750235 694 dbSNP
rs1366509544 695 dbSNP
rs1375457015 700 dbSNP
rs994796181 715 dbSNP
rs771288325 716 dbSNP
rs1445809894 718 dbSNP
rs977232869 721 dbSNP
rs1026236912 722 dbSNP
rs1369499752 723 dbSNP
rs1427394720 727 dbSNP
rs1376709523 743 dbSNP
rs4844103 746 dbSNP
rs1420294555 749 dbSNP
rs1375514245 753 dbSNP
rs1177271053 755 dbSNP
rs1009371678 758 dbSNP
rs975150005 759 dbSNP
rs1311127334 765 dbSNP
rs144185857 775 dbSNP
rs186093595 776 dbSNP
rs1307133184 783 dbSNP
rs1239397493 784 dbSNP
rs1383422720 786 dbSNP
rs1336008839 788 dbSNP
rs201788707 788 dbSNP
rs1289038336 789 dbSNP
rs1401072874 789 dbSNP
rs201425585 789 dbSNP
rs866510870 789 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 139562.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM1065667. RNA binding protein: AGO1. Condition:4-thiouridine ...

- Memczak S; Jens M; Elefsinioti A; Torti F; et al., 2013, Nature.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' ucgaaggacgagggacGAGAUGu 5'
                          |||||| 
Target 5' cauggugaaaccccacCUCUACa 3'
 		4 - 26
Article - Memczak S; Jens M; Elefsinioti A; Torti F; et al.
- Nature, 2013
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.
LinkOut: [PMID: 23446348]
CLIP-seq Support 1 for dataset GSM4903834
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_b
Location of target site NM_207320 | 3UTR | AAAAAAUACAAAAAUUAGCCGGGCGUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1065667
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / 4-thiouridine, ML_MM_6
Location of target site ENST00000338352.2 | 3UTR | CAACAUGGUGAAACCCCACCUCUACAAAAAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
65 hsa-miR-4732-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT076214 ALKBH5 alkB homolog 5, RNA demethylase 2 2
MIRT443015 C21orf91 chromosome 21 open reading frame 91 2 2
MIRT450317 ZNF562 zinc finger protein 562 2 2
MIRT450522 ZNF236 zinc finger protein 236 2 2
MIRT453952 ENTHD1 ENTH domain containing 1 2 2
MIRT463438 ZC3HAV1L zinc finger CCCH-type containing, antiviral 1 like 2 2
MIRT463971 WHSC1 nuclear receptor binding SET domain protein 2 2 4
MIRT465545 TOB2 transducer of ERBB2, 2 2 2
MIRT473817 MAP2K7 mitogen-activated protein kinase kinase 7 2 2
MIRT476716 FRK fyn related Src family tyrosine kinase 2 4
MIRT477373 ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7 2 2
MIRT477756 EDEM3 ER degradation enhancing alpha-mannosidase like protein 3 2 2
MIRT479642 CD4 CD4 molecule 2 2
MIRT483891 IL20RB interleukin 20 receptor subunit beta 2 6
MIRT485654 DAZAP2 DAZ associated protein 2 2 10
MIRT493568 HSP90AA1 heat shock protein 90 alpha family class A member 1 2 8
MIRT499708 NFATC2IP nuclear factor of activated T-cells 2 interacting protein 2 10
MIRT499933 MFSD8 major facilitator superfamily domain containing 8 2 2
MIRT509169 EFHC1 EF-hand domain containing 1 2 4
MIRT510594 TUBB2A tubulin beta 2A class IIa 2 2
MIRT510832 RTN4RL1 reticulon 4 receptor like 1 2 6
MIRT512419 LAYN layilin 2 4
MIRT516109 OARD1 O-acyl-ADP-ribose deacylase 1 2 8
MIRT517204 OTUD6A OTU deubiquitinase 6A 2 2
MIRT519106 ALG1 ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase 2 2
MIRT519283 SPCS1 signal peptidase complex subunit 1 2 2
MIRT519823 ZKSCAN4 zinc finger with KRAB and SCAN domains 4 2 2
MIRT521976 PFN2 profilin 2 2 4
MIRT526729 ZNF138 zinc finger protein 138 2 2
MIRT528765 CD1D CD1d molecule 2 2
MIRT531567 ILDR1 immunoglobulin like domain containing receptor 1 2 2
MIRT532173 SEC14L5 SEC14 like lipid binding 5 2 4
MIRT534865 QSER1 glutamine and serine rich 1 2 2
MIRT539948 SLC30A5 solute carrier family 30 member 5 2 2
MIRT543594 KIAA1549 KIAA1549 2 2
MIRT543964 RNF20 ring finger protein 20 2 2
MIRT544747 C8orf33 chromosome 8 open reading frame 33 2 2
MIRT544871 EHD3 EH domain containing 3 2 2
MIRT550459 OSCAR osteoclast associated, immunoglobulin-like receptor 2 2
MIRT551950 RNF157 ring finger protein 157 2 2
MIRT552504 ZIK1 zinc finger protein interacting with K protein 1 2 4
MIRT554074 SNX4 sorting nexin 4 2 4
MIRT555952 NUBP1 nucleotide binding protein 1 2 2
MIRT561097 VAMP8 vesicle associated membrane protein 8 2 2
MIRT561827 NUFIP2 NUFIP2, FMR1 interacting protein 2 2 2
MIRT563962 ZNF431 zinc finger protein 431 2 2
MIRT566851 LRRC58 leucine rich repeat containing 58 2 2
MIRT608133 TGFBR2 transforming growth factor beta receptor 2 2 2
MIRT615716 ZNF383 zinc finger protein 383 2 2
MIRT615959 ERBB3 erb-b2 receptor tyrosine kinase 3 2 4
MIRT620031 ST6GALNAC3 ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 2 2
MIRT621102 IL36B interleukin 36, beta 2 2
MIRT627383 TNNC1 troponin C1, slow skeletal and cardiac type 2 2
MIRT628263 DOK6 docking protein 6 2 2
MIRT635011 PDHB pyruvate dehydrogenase E1 beta subunit 2 2
MIRT636129 YIPF4 Yip1 domain family member 4 2 2
MIRT646812 COX19 COX19, cytochrome c oxidase assembly factor 2 2
MIRT652099 TRUB2 TruB pseudouridine synthase family member 2 2 2
MIRT662038 KSR2 kinase suppressor of ras 2 2 2
MIRT691530 ZNF208 zinc finger protein 208 2 2
MIRT698030 TRPV2 transient receptor potential cation channel subfamily V member 2 2 2
MIRT706642 NCBP2 nuclear cap binding protein subunit 2 2 2
MIRT707919 PRIMA1 proline rich membrane anchor 1 2 2
MIRT714664 CHRNE cholinergic receptor nicotinic epsilon subunit 2 2
MIRT721201 ZNF724P zinc finger protein 724 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4732-5p S-1 NULL 9949648 Microarray gastric cancer cells 24317477 2014 up-regulated
miR-4732-5p 5-Fluorouracil approved 3385 Microarray CNE cells 22614822 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4732 Fluorouracil 3385 NSC19893 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-mir-4732 Gemcitabine 60750 NSC613327 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-mir-4732 Topotecan 60699 NSC609699 approved resistant cell line (W1)
hsa-mir-4732 Tamoxifen 2733525 NSC180973 approved resistant cell line (MCF7)
hsa-miR-4732-5p Doxorubicin 31703 NSC123127 approved resistant High Chronic Myelogenous Leukemia cell line (K562)
hsa-miR-4732-5p Tamoxifen 2733525 NSC180973 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-4732-5p Fulvestrant 17756771 NSC719276 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-4732-5p Palbociclib 5330286 NSC758247 approved resistant High Breast Cancer cell line (T47D)
hsa-miR-4732-5p Temozolomide 5394 NSC362856 approved resistant cell line (U251)
hsa-miR-4732-5p Doxorubicin 31703 NSC123127 approved sensitive cell line (BAS)
hsa-miR-4732-5p Tamoxifen+Fulvestrant sensitive cell line (LCC9)
hsa-miR-4732-5p Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-4732-5p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-miR-4732-5p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)
hsa-miR-4732-5p Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR3)
hsa-miR-4732-5p Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR1)
hsa-miR-4732-5p Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR4)

Error report submission