miRTarBase - #MIRT517385


—
pre-miRNA Information
pre-miRNA hsa-mir-4421   
Genomic Coordinates chr1: 51059837 - 51059905
Description Homo sapiens miR-4421 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4421
Sequence 43| ACCUGUCUGUGGAAAGGAGCUA |64
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1222858590 1 dbSNP
rs1334405255 19 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol METTL7A   
Synonyms AAM-B
Description methyltransferase like 7A
Transcript NM_014033   
Expression
Putative miRNA Targets on METTL7A
3'UTR of METTL7A
(miRNA target sites are highlighted)		 
>METTL7A|NM_014033|3'UTR
   1 TGTGAGCTGGCAGTTAAGAGCTGAATGGCTCAAAGAATTTAAAGCTTCAGTTTTACATTTAAAATGCTAAGTGGGAGAAG
  81 AGAAACCTTTTTTTTGGGGGGCGGTTTTTTTGGTTTGTTGTTGGTTTTTTTTTTTTTTTTGGCGGGAAGAAAGAGTTTTG
 161 CTCTTGTTGCCCAGGCTGGAGTGCAATGACGTGATCTCCGCTCACTGCAACCTCCACCTCGCGGGTTTAAGCGATTCTTC
 241 TGCCTCAGCCTCCCTAGTAGCTGGGATTACAGGTGCCCACCACCATGCCCAGCTAATTTGTATTTTTAGTTGAGACAGGG
 321 TTTCACTACGTTGGCCAGGCTGGTCTTGAACTCCTGATCTCAGGCAATCCACCCACCTCAGCCTCCCAAAGTGCTGGGAT
 401 GACAGGCGTGAGCAACCGCACCCAGCTTAAGGTTTTTTTGTTTTGTTTTGAGACGGAGTTTTCGCTCTTGTTGCCCAGGC
 481 TGGAGTGCAATGCTGTGATCTCAGCTTACCACAACCTCCACCTCCCGGGTTCAAGTGATTCACCTGCCTCAGCCTCCTGA
 561 GTAGCTGGTATTACAGGCATGCGTCACCACGCCGGCTAATTTTGTACTTTTAGTAGAGATGGTGTTTCCCCACGTTGGTC
 641 AGTCTGGTCTCAAATTCCTGACCTCAGGTGATCTGCCTGCCTCGGCCTCCCAAAGTGCTGTGATTACAGACGTCAGCCAC
 721 CATGCCTGGCCTGAAACCTTTTTTAGGTAAAGTTGAATTCCATCCTTAAAAGTTTCTGTTATATCCTATTTAGCCATTTT
 801 CTATTGTCTCCCAAAGAATTCACATCAAAAAAACAGCTTTGAACTCCCCCTTCAAAGGAAACAGTCGACTTTCATAATTA
 881 GCATCTACCATTATCCCCAAATCTTATTTTATTCATTGACTTGAAATTTTTTCCAATTGCTTTTTTTTTTTTTTTTTTAA
 961 GGTTAAGAGCAGAGGTTTACTAGGCCAAAGAAAGAGAATAGCTCTCTGTTGCAGAGAGGGGTCCTGGAGAAATGGGTTAC
1041 CCCAGTTGTCTTATTTAAATGGTTACCCATCAGATTTTAATTTTATCTTCTCTTTGAGAGCTTGGTAATAAGAAGCACTT
1121 AAATCACTCCAAAGAAGACTTTAAAAAGGGAGCAGTGAAAAGGTCTTAATAATTTATTGATTGAATTAAGAAATACTAGC
1201 TAATTAAGAATCTGAGTCTAAACAGCACAGATTTTTTCTTTCTGCTTTTAAATTGTGTTTTAAAAAAAGAGACAGGGGGC
1281 TGGGCGTGGTGGCTCACGCCTGTAATCCTAGCACTTTGGGAGGCCGAGGCGGGTGGATCACGAGGTAGGAGTTAAAGACC
1361 AGCCTGGCCAACATGGCAAAACCCTACTAAAGATACAAAAAAAAAAAAAAATTAGCCAGGCGTGGTGGTGGGTGCCTGTA
1441 ATCCCAGGTACTTGGAAGGCTGAGGCAGGAGAATCTCTTGAACCCAGAAGGCGAAGGTTGCAGTGAACCGAGATCATGCC
1521 ATTGTACTCTAGCCTGGGTGACAAGAGCAAGACTCCGTCTCAAAAAAAAAAAAAAAAAAAAAAAGAAGTAGAGACAGGGA
1601 GACAGGGTCTCACTGTGTTGCCTAGGCCGGTCTTGAACTCCTGGGCTCAAGTGATTCTCCCACCTTGACCTCCTAAATTG
1681 TTGGGATTACAGGTGTGAGACAGTGCACCTGGCCGAAATAGCTCAAGTTTCTGAAAAACAAATCTGAATCTATTTGTTAT
1761 TCTTAGCGTCACTGGTCTGGCTTTCAGAATTAACATACAAGGTTGCCACACCTAGTTCTGCCCAGCTTTATGTCTTTTAT
1841 TCCAGTATTCCACCAAAGTTTGTTTTCCTGCATTCCAGTTCTCAAGTCTTAAGATAAAGATTGTACTTGACAGTTTAGTA
1921 TATCCATAAAACTATTTGAGGTGGTTAAGGTTCTTGGGTTCATTTTCCTTAATACTTTGCTGAATATTGTAGATTGTAGG
2001 CAATGAAAAAGTCTACTAAATTAGGAAAACCTTGAATAATTAGGTATCCTAGGTAAGAGCCCCTAAACATCAAGCAATCT
2081 GTGAGTCTGTAAAGAAATAAATATTTTTTGGATTATTCTTATCTAATTCCACCCCTGTTGGAAGATGATTTCTTTGTTCT
2161 TTGCAACTATGGAAGCTGTGAAAATCATCACAAGTGCCTCTGAAAGCGAGTGTTAGGTTGGTTAGAGGGTTTAATATTTT
2241 CTGCAATGGTTTGTAGGAATTTTAATAAATGTAGTATATTTTCTGAGATGATTTTGTAAAAGTACTATTTTAAATATCAA
2321 ATCAACCAATAAATTCACATTTGTGTTAGGAACAGAAATATGGTTTA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' aucgAGGAAAGGUG--UCUGUCCa 5'
              | :|||: ::  ||||||| 
Target 5' tttgTATTTTTAGTTGAGACAGGg 3'
 297 - 320 148.00 -10.50
2 
miRNA  3' aucgaggaaagGUGUCUGUCCa 5'
                     :| ||||||| 
Target 5' aaaaaaagaagTAGAGACAGGg 3'
 1578 - 1599 143.00 -11.90
3 
miRNA  3' aucgaggaaaggUGUCUGUCCa 5'
                      | ||||||| 
Target 5' tgttttaaaaaaAGAGACAGGg 3'
 1256 - 1277 142.00 -11.00
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31592508 7 COSMIC
COSN31591491 11 COSMIC
COSN31567454 83 COSMIC
COSN30676969 96 COSMIC
COSN7373302 96 COSMIC
COSN20077653 103 COSMIC
COSN27405338 141 COSMIC
COSN32071831 142 COSMIC
COSN5796350 684 COSMIC
COSN20109573 958 COSMIC
COSN20092570 1165 COSMIC
COSN22690605 1206 COSMIC
COSN20447401 1721 COSMIC
COSN29932741 2242 COSMIC
rs319941 1497 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1198967164 1 dbSNP
rs778701616 4 dbSNP
rs371476027 5 dbSNP
rs757470610 7 dbSNP
rs1014356908 10 dbSNP
rs781337571 11 dbSNP
rs1419096080 16 dbSNP
rs1412523148 24 dbSNP
rs1045809294 27 dbSNP
rs375543743 36 dbSNP
rs770010577 53 dbSNP
rs1027116682 63 dbSNP
rs969754496 66 dbSNP
rs1001405059 68 dbSNP
rs1216291675 74 dbSNP
rs1487513906 76 dbSNP
rs1288706748 85 dbSNP
rs928278778 87 dbSNP
rs1310717727 88 dbSNP
rs1361445994 88 dbSNP
rs959975490 88 dbSNP
rs1466984282 93 dbSNP
rs368952628 96 dbSNP
rs913090167 97 dbSNP
rs1009106137 103 dbSNP
rs372995739 104 dbSNP
rs1010556973 113 dbSNP
rs1454311124 114 dbSNP
rs1192496378 125 dbSNP
rs1264381130 125 dbSNP
rs1475918652 125 dbSNP
rs571166713 125 dbSNP
rs796138630 125 dbSNP
rs925396935 125 dbSNP
rs1206206052 126 dbSNP
rs1488468604 128 dbSNP
rs1344437105 130 dbSNP
rs201354558 131 dbSNP
rs1257604093 132 dbSNP
rs1280451401 132 dbSNP
rs932742452 138 dbSNP
rs1312765281 141 dbSNP
rs1203722667 142 dbSNP
rs182969639 144 dbSNP
rs1482120938 145 dbSNP
rs1184372015 148 dbSNP
rs1252849719 150 dbSNP
rs1477803322 157 dbSNP
rs1049745509 165 dbSNP
rs1394653676 167 dbSNP
rs1427682795 173 dbSNP
rs1463770741 175 dbSNP
rs1375117726 179 dbSNP
rs891106899 180 dbSNP
rs1434059630 182 dbSNP
rs1170377666 190 dbSNP
rs1369195764 191 dbSNP
rs1196072733 195 dbSNP
rs1468958249 196 dbSNP
rs188043649 200 dbSNP
rs369125040 201 dbSNP
rs1308083530 204 dbSNP
rs1257585427 208 dbSNP
rs193093014 212 dbSNP
rs565829859 217 dbSNP
rs575319411 218 dbSNP
rs1433841586 219 dbSNP
rs751393955 221 dbSNP
rs1019962187 222 dbSNP
rs1368041117 223 dbSNP
rs537301222 224 dbSNP
rs1295342144 229 dbSNP
rs1008452169 231 dbSNP
rs986574503 233 dbSNP
rs544179987 234 dbSNP
rs1037216015 236 dbSNP
rs963761031 243 dbSNP
rs897329978 245 dbSNP
rs11169622 249 dbSNP
rs974904397 250 dbSNP
rs1465806707 253 dbSNP
rs1376345948 256 dbSNP
rs1176040353 260 dbSNP
rs920748830 265 dbSNP
rs1489025190 266 dbSNP
rs1455133585 268 dbSNP
rs1238121802 270 dbSNP
rs996040271 274 dbSNP
rs1439669144 276 dbSNP
rs200659374 278 dbSNP
rs930921776 279 dbSNP
rs1001274023 285 dbSNP
rs984082804 289 dbSNP
rs761450422 304 dbSNP
rs529935738 308 dbSNP
rs1451859314 313 dbSNP
rs1168746407 318 dbSNP
rs1278006824 319 dbSNP
rs1236390193 321 dbSNP
rs1384074194 325 dbSNP
rs1348430165 328 dbSNP
rs1308451749 330 dbSNP
rs139247956 331 dbSNP
rs560067365 338 dbSNP
rs1045756344 341 dbSNP
rs1350057238 347 dbSNP
rs532148201 349 dbSNP
rs905987471 360 dbSNP
rs1329089231 375 dbSNP
rs551475948 378 dbSNP
rs1395129344 380 dbSNP
rs937391251 381 dbSNP
rs1429804912 387 dbSNP
rs1054320864 409 dbSNP
rs1020578751 411 dbSNP
rs968659991 412 dbSNP
rs1367326682 418 dbSNP
rs1267875818 419 dbSNP
rs1471188941 420 dbSNP
rs1364501716 434 dbSNP
rs1187104217 442 dbSNP
rs1440966479 449 dbSNP
rs576901712 450 dbSNP
rs571368091 455 dbSNP
rs932751084 456 dbSNP
rs1285156670 459 dbSNP
rs1020586726 464 dbSNP
rs779644047 465 dbSNP
rs985484925 466 dbSNP
rs372864991 468 dbSNP
rs1322526373 482 dbSNP
rs891036960 486 dbSNP
rs1353113724 489 dbSNP
rs944007662 492 dbSNP
rs1037248666 500 dbSNP
rs1007887261 509 dbSNP
rs1246563769 511 dbSNP
rs1296856234 515 dbSNP
rs56840343 522 dbSNP
rs931575647 526 dbSNP
rs1162679075 527 dbSNP
rs963790338 528 dbSNP
rs1049070201 543 dbSNP
rs754344926 572 dbSNP
rs1475399000 574 dbSNP
rs1471534786 578 dbSNP
rs906014837 579 dbSNP
rs973763419 583 dbSNP
rs1035413617 584 dbSNP
rs1456356603 591 dbSNP
rs1156754484 592 dbSNP
rs1279922992 594 dbSNP
rs540806863 595 dbSNP
rs375575941 605 dbSNP
rs1340295986 611 dbSNP
rs1268849643 617 dbSNP
rs1433344138 621 dbSNP
rs1336025112 634 dbSNP
rs369296108 635 dbSNP
rs1009943634 636 dbSNP
rs1403626935 638 dbSNP
rs373396940 656 dbSNP
rs1165882707 660 dbSNP
rs969067766 663 dbSNP
rs978682478 672 dbSNP
rs1184495558 680 dbSNP
rs1476290691 684 dbSNP
rs950329138 685 dbSNP
rs1228015904 688 dbSNP
rs1242585914 691 dbSNP
rs528600452 696 dbSNP
rs1466727636 701 dbSNP
rs1254410896 705 dbSNP
rs953186279 706 dbSNP
rs927266492 710 dbSNP
rs1270452073 712 dbSNP
rs573490590 712 dbSNP
rs1216650746 713 dbSNP
rs1340527269 723 dbSNP
rs937422400 726 dbSNP
rs912607130 738 dbSNP
rs1373278050 739 dbSNP
rs1326729075 761 dbSNP
rs1446143717 770 dbSNP
rs1352908939 772 dbSNP
rs1172840087 773 dbSNP
rs1411430606 774 dbSNP
rs944123789 782 dbSNP
rs539192951 787 dbSNP
rs1189075240 794 dbSNP
rs558687498 798 dbSNP
rs878897011 805 dbSNP
rs1237536386 815 dbSNP
rs945904081 824 dbSNP
rs1206238732 825 dbSNP
rs1179574932 827 dbSNP
rs1438718054 829 dbSNP
rs777801678 845 dbSNP
rs1413652770 846 dbSNP
rs1350604790 848 dbSNP
rs1041548583 850 dbSNP
rs891059276 858 dbSNP
rs1008085227 859 dbSNP
rs1457601214 860 dbSNP
rs1300086707 863 dbSNP
rs1371346946 863 dbSNP
rs1443293234 865 dbSNP
rs114891014 867 dbSNP
rs906040746 868 dbSNP
rs899483111 869 dbSNP
rs937461382 871 dbSNP
rs544264219 875 dbSNP
rs764523162 884 dbSNP
rs1417977800 888 dbSNP
rs1405212279 892 dbSNP
rs1336323008 904 dbSNP
rs995217571 911 dbSNP
rs1356185596 916 dbSNP
rs1236545978 930 dbSNP
rs1209084745 937 dbSNP
rs1027113719 938 dbSNP
rs374892078 939 dbSNP
rs1281645094 940 dbSNP
rs1216577179 941 dbSNP
rs1378634569 941 dbSNP
rs377202263 941 dbSNP
rs397851060 941 dbSNP
rs398019536 941 dbSNP
rs56130607 941 dbSNP
rs770201700 941 dbSNP
rs1286706088 942 dbSNP
rs1313376205 944 dbSNP
rs1453050560 954 dbSNP
rs1342909699 959 dbSNP
rs1352515447 959 dbSNP
rs1229436735 960 dbSNP
rs1274604807 962 dbSNP
rs1343559725 963 dbSNP
rs560705578 970 dbSNP
rs1185418008 981 dbSNP
rs1476375817 984 dbSNP
rs373902631 997 dbSNP
rs1193563341 1000 dbSNP
rs1485146728 1001 dbSNP
rs770877323 1002 dbSNP
rs951157985 1010 dbSNP
rs776738669 1019 dbSNP
rs1015076599 1027 dbSNP
rs1482455560 1030 dbSNP
rs904165135 1034 dbSNP
rs1202358896 1041 dbSNP
rs971670967 1045 dbSNP
rs115758497 1051 dbSNP
rs1381449932 1063 dbSNP
rs1261078511 1067 dbSNP
rs1290590659 1072 dbSNP
rs1430756004 1073 dbSNP
rs367811557 1074 dbSNP
rs537350913 1074 dbSNP
rs1162348619 1081 dbSNP
rs1462745589 1089 dbSNP
rs1418144016 1091 dbSNP
rs145221743 1092 dbSNP
rs958656751 1100 dbSNP
rs796893638 1103 dbSNP
rs990142220 1105 dbSNP
rs1264413643 1114 dbSNP
rs1478850988 1128 dbSNP
rs1251291596 1132 dbSNP
rs914680050 1133 dbSNP
rs1018726308 1137 dbSNP
rs946132514 1140 dbSNP
rs1226363713 1149 dbSNP
rs1305569381 1151 dbSNP
rs1297601437 1152 dbSNP
rs537093162 1158 dbSNP
rs1369598337 1163 dbSNP
rs1041970369 1165 dbSNP
rs11503921 1166 dbSNP
rs1323243569 1167 dbSNP
rs1442470134 1180 dbSNP
rs912366769 1180 dbSNP
rs1173107873 1184 dbSNP
rs762012577 1187 dbSNP
rs1297274476 1191 dbSNP
rs1460768469 1203 dbSNP
rs1375183242 1210 dbSNP
rs1039554187 1215 dbSNP
rs11503625 1219 dbSNP
rs560361245 1226 dbSNP
rs1454266458 1229 dbSNP
rs1393822405 1233 dbSNP
rs899514137 1259 dbSNP
rs1250017697 1262 dbSNP
rs377548291 1262 dbSNP
rs3180984 1270 dbSNP
rs995170185 1271 dbSNP
rs1048059498 1272 dbSNP
rs1252919460 1274 dbSNP
rs965464126 1274 dbSNP
rs1372690943 1275 dbSNP
rs972826066 1276 dbSNP
rs1235792660 1278 dbSNP
rs1371156699 1279 dbSNP
rs1392165340 1280 dbSNP
rs1305813878 1285 dbSNP
rs918603041 1286 dbSNP
rs879288414 1287 dbSNP
rs952716446 1291 dbSNP
rs886883454 1293 dbSNP
rs1003954716 1294 dbSNP
rs927568106 1296 dbSNP
rs1015520661 1298 dbSNP
rs561292157 1299 dbSNP
rs1421050444 1303 dbSNP
rs3180343 1305 dbSNP
rs3180985 1306 dbSNP
rs765524209 1307 dbSNP
rs1003129550 1312 dbSNP
rs1034566123 1313 dbSNP
rs1225613524 1317 dbSNP
rs1205561138 1321 dbSNP
rs1276141547 1324 dbSNP
rs945802913 1325 dbSNP
rs1278077393 1326 dbSNP
rs1483219042 1327 dbSNP
rs1345103251 1328 dbSNP
rs1208878912 1331 dbSNP
rs1264760534 1332 dbSNP
rs993656892 1335 dbSNP
rs1337091780 1338 dbSNP
rs1307296048 1340 dbSNP
rs1453131735 1342 dbSNP
rs958941720 1343 dbSNP
rs1315314716 1344 dbSNP
rs1435954141 1346 dbSNP
rs1027805481 1347 dbSNP
rs3180344 1348 dbSNP
rs3180345 1355 dbSNP
rs319940 1366 dbSNP
rs1447558253 1368 dbSNP
rs3180346 1374 dbSNP
rs980850850 1393 dbSNP
rs1166852953 1395 dbSNP
rs1034106442 1397 dbSNP
rs1283482235 1397 dbSNP
rs35013187 1397 dbSNP
rs398019537 1397 dbSNP
rs71089713 1397 dbSNP
rs1392095748 1398 dbSNP
rs543664528 1404 dbSNP
rs1352241402 1414 dbSNP
rs1293174705 1415 dbSNP
rs1388796334 1417 dbSNP
rs1018758836 1418 dbSNP
rs1449225128 1419 dbSNP
rs914564920 1422 dbSNP
rs1326971284 1423 dbSNP
rs1365181448 1424 dbSNP
rs960660347 1427 dbSNP
rs1383975543 1429 dbSNP
rs992158529 1430 dbSNP
rs961831386 1431 dbSNP
rs1164475027 1432 dbSNP
rs1460124414 1444 dbSNP
rs1420307729 1446 dbSNP
rs3180986 1447 dbSNP
rs1166742414 1454 dbSNP
rs3180987 1458 dbSNP
rs1433525319 1460 dbSNP
rs967878957 1478 dbSNP
rs1300363973 1479 dbSNP
rs994674967 1485 dbSNP
rs3180989 1487 dbSNP
rs977507792 1493 dbSNP
rs185500414 1494 dbSNP
rs565085447 1496 dbSNP
rs319941 1497 dbSNP
rs550991099 1499 dbSNP
rs1210260263 1503 dbSNP
rs1274701360 1505 dbSNP
rs3180991 1508 dbSNP
rs187621980 1510 dbSNP
rs767344349 1511 dbSNP
rs3180992 1512 dbSNP
rs958965881 1517 dbSNP
rs1230344966 1519 dbSNP
rs377657191 1522 dbSNP
rs917434157 1523 dbSNP
rs1438806879 1525 dbSNP
rs1396911924 1531 dbSNP
rs370491373 1535 dbSNP
rs1405713061 1540 dbSNP
rs1418575727 1544 dbSNP
rs1164135786 1546 dbSNP
rs1166081436 1546 dbSNP
rs1476320091 1548 dbSNP
rs762022573 1551 dbSNP
rs1366990556 1555 dbSNP
rs1466770282 1556 dbSNP
rs536612179 1557 dbSNP
rs546985900 1558 dbSNP
rs1437608566 1561 dbSNP
rs1172992263 1562 dbSNP
rs1271400532 1562 dbSNP
rs1275625640 1562 dbSNP
rs1326535621 1562 dbSNP
rs1353692030 1562 dbSNP
rs1371041011 1562 dbSNP
rs1415221282 1562 dbSNP
rs1431435600 1562 dbSNP
rs1441837981 1562 dbSNP
rs1452001637 1562 dbSNP
rs754366448 1562 dbSNP
rs78329969 1566 dbSNP
rs1388373633 1568 dbSNP
rs1433279355 1572 dbSNP
rs886750253 1581 dbSNP
rs1323169368 1583 dbSNP
rs946201203 1583 dbSNP
rs939784486 1586 dbSNP
rs1041861133 1587 dbSNP
rs1280216618 1588 dbSNP
rs1209401426 1589 dbSNP
rs1350134347 1590 dbSNP
rs925763948 1590 dbSNP
rs1046108516 1594 dbSNP
rs1371409373 1596 dbSNP
rs1281518634 1597 dbSNP
rs1341952164 1601 dbSNP
rs3180347 1605 dbSNP
rs907377790 1610 dbSNP
rs3209367 1616 dbSNP
rs3209368 1617 dbSNP
rs779962175 1629 dbSNP
rs1267022388 1630 dbSNP
rs1360842435 1631 dbSNP
rs567121530 1636 dbSNP
rs1210308194 1639 dbSNP
rs1268737025 1643 dbSNP
rs3209369 1645 dbSNP
rs3209370 1646 dbSNP
rs539284466 1650 dbSNP
rs3209371 1651 dbSNP
rs3209372 1653 dbSNP
rs3209373 1654 dbSNP
rs3209374 1657 dbSNP
rs117919526 1658 dbSNP
rs3209375 1659 dbSNP
rs1040241220 1665 dbSNP
rs1315695914 1670 dbSNP
rs569006330 1679 dbSNP
rs1186406582 1696 dbSNP
rs897673521 1699 dbSNP
rs1022061478 1709 dbSNP
rs1215101720 1711 dbSNP
rs1315255905 1714 dbSNP
rs967364294 1715 dbSNP
rs537522287 1716 dbSNP
rs977915321 1733 dbSNP
rs1292386632 1739 dbSNP
rs1412708509 1763 dbSNP
rs375440197 1768 dbSNP
rs192585715 1769 dbSNP
rs1429385032 1775 dbSNP
rs1342965794 1782 dbSNP
rs146870720 1788 dbSNP
rs1160914062 1796 dbSNP
rs888566058 1798 dbSNP
rs1006028970 1799 dbSNP
rs1019689636 1804 dbSNP
rs958673165 1821 dbSNP
rs1257458264 1827 dbSNP
rs965433009 1829 dbSNP
rs1161783087 1846 dbSNP
rs977675149 1851 dbSNP
rs993082903 1854 dbSNP
rs1346354970 1865 dbSNP
rs1484932142 1870 dbSNP
rs975242315 1871 dbSNP
rs1209457954 1879 dbSNP
rs879515167 1882 dbSNP
rs1403724598 1894 dbSNP
rs1414803752 1896 dbSNP
rs1231171882 1906 dbSNP
rs1323333232 1908 dbSNP
rs1287346756 1921 dbSNP
rs1313305662 1924 dbSNP
rs1348197065 1939 dbSNP
rs574365584 1945 dbSNP
rs931237874 1951 dbSNP
rs1393218437 1958 dbSNP
rs1323541634 1967 dbSNP
rs984032765 1972 dbSNP
rs1311602995 1983 dbSNP
rs968027636 1990 dbSNP
rs908208800 1993 dbSNP
rs939669267 1998 dbSNP
rs1427199509 1999 dbSNP
rs926096164 2016 dbSNP
rs199685384 2021 dbSNP
rs1046479437 2024 dbSNP
rs754883219 2025 dbSNP
rs1063847 2030 dbSNP
rs935792573 2039 dbSNP
rs1486709573 2041 dbSNP
rs906304289 2044 dbSNP
rs937729817 2045 dbSNP
rs1211898654 2069 dbSNP
rs319942 2073 dbSNP
rs1471718443 2078 dbSNP
rs115988708 2095 dbSNP
rs576724480 2102 dbSNP
rs1203570929 2109 dbSNP
rs1021842170 2123 dbSNP
rs1409165323 2134 dbSNP
rs760394627 2135 dbSNP
rs1299769223 2144 dbSNP
rs1174589930 2146 dbSNP
rs781141469 2152 dbSNP
rs1228470223 2154 dbSNP
rs1361355521 2161 dbSNP
rs545635713 2169 dbSNP
rs184070661 2174 dbSNP
rs1388211027 2192 dbSNP
rs1391021121 2202 dbSNP
rs1400018221 2203 dbSNP
rs73308085 2208 dbSNP
rs1460817386 2209 dbSNP
rs1372894493 2213 dbSNP
rs1169835131 2222 dbSNP
rs1053450 2226 dbSNP
rs1048918032 2232 dbSNP
rs1434150280 2234 dbSNP
rs965464195 2244 dbSNP
rs544391937 2247 dbSNP
rs1433925927 2260 dbSNP
rs1250084111 2267 dbSNP
rs975442186 2267 dbSNP
rs1034395568 2271 dbSNP
rs894488468 2278 dbSNP
rs1276654651 2291 dbSNP
rs1205872873 2293 dbSNP
rs1028133485 2295 dbSNP
rs952538570 2300 dbSNP
rs371084140 2314 dbSNP
rs1277499444 2322 dbSNP
rs547610708 2335 dbSNP
rs908490146 2339 dbSNP
rs1331286902 2345 dbSNP
rs530043160 2346 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HeLa
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in Chi_124B_2A8_130_50. RNA binding protein: AGO. Condition:HeLa cell miR-124 + B ...

- Chi SW; Zang JB; Mele A; Darnell RB, 2009, Nature.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' aucgaggaaagGUGUCUGUCCa 5'
                     :| ||||||| 
Target 5' ---aaaagaagUAGAGACAGG- 3'
 		1 - 18
Article - Chi SW; Zang JB; Mele A; Darnell RB
- Nature, 2009
MicroRNAs (miRNAs) have critical roles in the regulation of gene expression; however, as miRNA activity requires base pairing with only 6-8 nucleotides of messenger RNA, predicting target mRNAs is a major challenge. Recently, high-throughput sequencing of RNAs isolated by crosslinking immunoprecipitation (HITS-CLIP) has identified functional protein-RNA interaction sites. Here we use HITS-CLIP to covalently crosslink native argonaute (Ago, also called Eif2c) protein-RNA complexes in mouse brain. This produced two simultaneous data sets-Ago-miRNA and Ago-mRNA binding sites-that were combined with bioinformatic analysis to identify interaction sites between miRNA and target mRNA. We validated genome-wide interaction maps for miR-124, and generated additional maps for the 20 most abundant miRNAs present in P13 mouse brain. Ago HITS-CLIP provides a general platform for exploring the specificity and range of miRNA action in vivo, and identifies precise sequences for targeting clinically relevant miRNA-mRNA interactions.
LinkOut: [PMID: 19536157]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 25840.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM1065667. RNA binding protein: AGO1. Condition:4-thiouridine ...

- Memczak S; Jens M; Elefsinioti A; Torti F; et al., 2013, Nature.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' aucGAGGAAAGGUGUCUGUCCa 5'
             || | ||   |||:| || 
Target 5' ucaCUACGUUGGCCAGGCUGGu 3'
 		9 - 30
Article - Memczak S; Jens M; Elefsinioti A; Torti F; et al.
- Nature, 2013
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.
LinkOut: [PMID: 23446348]
CLIP-seq Support 1 for dataset GSM4903833
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_a
Location of target site NM_014033 | 3UTR | AAAAAAAAAAAAAAAGAAGUAGAGACAGGGAGACAGGGUCUCACUGUGUUGCCUAGGCCGGUCUUGAACUCCUGGGCUCAAGUGAUUCUCCCACCUUGACCUCCUAAAUUGUUGGGAUUACAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM4903834
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_b
Location of target site NM_014033 | 3UTR | AAAAAAAGAAGUAGAGACAGGGAGACAGGGUCUCACUGUGUUGCCUAGGCCGGUCUUGAACUCCUGGGCUCAAGUGAUUCUCCCACCUUGACCUCCUAAAUUGUUGGGAUUACAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM4903835
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_c
Location of target site NM_014033 | 3UTR | AAAAAAAGAAGUAGAGACAGGGAGACAGGGUCUCACUGUGUUGCCUAGGCCGGUCUUGAACUCCUGGGCUCAAGUGAUUCUCCCACCUUGACCUCCUAAAUUGUUGGGAUUACAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM4903836
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_a
Location of target site NM_014033 | 3UTR | AAAAAAGAAGUAGAGACAGGGAGACAGGGUCUCACUGUGUUGCCUAGGCCGGUCUUGAACUCCUGGGCUCAAGUGAUUCUCCCACCUUGACCUCCUAAAUUGUUGGGAUUACAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM4903837
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_b
Location of target site NM_014033 | 3UTR | AGACAGGGAGACAGGGUCUCACUGUGUUGCCUAGGCCGGUCUUGAACUCCUGGGCUCAAGUGAUUCUCCCACCUUGACCUCCUAAAUUGUUGGGAUUACAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM4903838
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_c
Location of target site NM_014033 | 3UTR | AAAAAAAAGAAGUAGAGACAGGGAGACAGGGUCUCACUGUGUUGCCUAGGCCGGUCUUGAACUCCUGGGCUCAAGUGAUUCUCCCACCUUGACCUCCUAAAUUGUUGGGAUUACAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 7 for dataset Chi_124B_2A8_130_50
Method / RBP HITS-CLIP / AGO
Cell line / Condition HeLa / HeLa cell miR-124 + B
Location of target site ENST00000332160.4 | 3UTR | AAAAGAAGUAGAGACAGG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 19536157 / Chi_HITSCLIP
CLIP-seq Viewer Link
CLIP-seq Support 8 for dataset GSM1065667
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / 4-thiouridine, ML_MM_6
Location of target site ENST00000332160.4 | 3UTR | ACAGGGUUUCACUACGUUGGCCAGGCUGGUCUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
151 hsa-miR-4421 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT293805 FEM1A fem-1 homolog A 2 2
MIRT468824 RSRC2 arginine and serine rich coiled-coil 2 2 6
MIRT470326 PPP6R1 protein phosphatase 6 regulatory subunit 1 2 2
MIRT474293 LAMTOR3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 2 2
MIRT480821 BLCAP bladder cancer associated protein 2 10
MIRT496455 N6AMT1 N-6 adenine-specific DNA methyltransferase 1 2 2
MIRT500021 ABCF2 ATP binding cassette subfamily F member 2 2 8
MIRT508622 PLA2G2C phospholipase A2 group IIC 2 2
MIRT514258 S1PR2 sphingosine-1-phosphate receptor 2 2 2
MIRT514574 MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2 4
MIRT515040 EBNA1BP2 EBNA1 binding protein 2 2 2
MIRT515686 TFPI tissue factor pathway inhibitor 2 2
MIRT517385 METTL7A methyltransferase like 7A 2 4
MIRT519320 TIMELESS timeless circadian clock 2 2
MIRT519728 ZNF460 zinc finger protein 460 2 2
MIRT520243 USP9X ubiquitin specific peptidase 9, X-linked 2 4
MIRT520266 URGCP upregulator of cell proliferation 2 2
MIRT523695 FHL2 four and a half LIM domains 2 2 4
MIRT525357 HPR haptoglobin-related protein 2 2
MIRT530203 ALX1 ALX homeobox 1 2 2
MIRT530217 UGDH UDP-glucose 6-dehydrogenase 2 2
MIRT539888 IRGQ immunity related GTPase Q 2 2
MIRT540203 ARHGAP18 Rho GTPase activating protein 18 2 2
MIRT540544 MYO1H myosin IH 2 2
MIRT540946 SLC25A43 solute carrier family 25 member 43 2 2
MIRT541928 ORC1 origin recognition complex subunit 1 2 4
MIRT542086 IKZF3 IKAROS family zinc finger 3 2 2
MIRT542191 FUT1 fucosyltransferase 1 (H blood group) 2 6
MIRT542342 LIMD1 LIM domains containing 1 2 2
MIRT542499 WDR13 WD repeat domain 13 2 2
MIRT542571 ZNF280B zinc finger protein 280B 2 2
MIRT542706 RPS15A ribosomal protein S15a 2 2
MIRT542902 HSBP1 heat shock factor binding protein 1 2 2
MIRT557044 HOXB3 homeobox B3 2 2
MIRT559285 AURKA aurora kinase A 2 2
MIRT563692 RPS26 ribosomal protein S26 2 2
MIRT564324 CCNT1 cyclin T1 2 2
MIRT573774 PRKAG1 protein kinase AMP-activated non-catalytic subunit gamma 1 2 2
MIRT576319 Zfp703 zinc finger protein 703 1 1
MIRT576660 Fam216a family with sequence similarity 216, member A 2 2
MIRT609117 ZNF703 zinc finger protein 703 2 7
MIRT609183 DPY19L3 dpy-19 like C-mannosyltransferase 3 2 4
MIRT610539 FAM46A family with sequence similarity 46 member A 2 4
MIRT611598 JAKMIP3 Janus kinase and microtubule interacting protein 3 2 4
MIRT618036 CTU1 cytosolic thiouridylase subunit 1 2 2
MIRT622442 RNF217 ring finger protein 217 2 2
MIRT622562 PTPN3 protein tyrosine phosphatase, non-receptor type 3 2 2
MIRT623831 GATSL2 cytosolic arginine sensor for mTORC1 subunit 2 2 2
MIRT624397 CD3D CD3d molecule 2 2
MIRT627578 SLC24A4 solute carrier family 24 member 4 2 2
MIRT627862 PITPNM3 PITPNM family member 3 2 2
MIRT631108 SLC15A2 solute carrier family 15 member 2 2 2
MIRT631115 ATCAY ATCAY, caytaxin 2 2
MIRT631204 ZNF724P zinc finger protein 724 2 2
MIRT631454 DLEU1 deleted in lymphocytic leukemia 1 (non-protein coding) 2 2
MIRT632347 SWSAP1 SWIM-type zinc finger 7 associated protein 1 2 2
MIRT633901 FGF10 fibroblast growth factor 10 2 2
MIRT634398 PLSCR1 phospholipid scramblase 1 2 2
MIRT634924 CHMP1B charged multivesicular body protein 1B 2 2
MIRT635867 SLC11A2 solute carrier family 11 member 2 2 2
MIRT636633 CHAF1B chromatin assembly factor 1 subunit B 2 2
MIRT637153 PCDHA6 protocadherin alpha 6 2 2
MIRT640789 GRIK3 glutamate ionotropic receptor kainate type subunit 3 2 2
MIRT645416 FAM110A family with sequence similarity 110 member A 2 2
MIRT645530 ZWINT ZW10 interacting kinetochore protein 2 2
MIRT647100 GNL3L G protein nucleolar 3 like 2 2
MIRT649262 IMPA2 inositol monophosphatase 2 2 2
MIRT650491 UFM1 ubiquitin fold modifier 1 2 2
MIRT650795 GSR glutathione-disulfide reductase 2 2
MIRT651039 ZNF652 zinc finger protein 652 2 2
MIRT654018 SCN2B sodium voltage-gated channel beta subunit 2 2 2
MIRT655523 PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 2 2
MIRT657308 HOXA9 homeobox A9 2 2
MIRT657789 GK5 glycerol kinase 5 (putative) 2 4
MIRT659400 CORO2A coronin 2A 2 2
MIRT659992 C2CD2L C2CD2 like 2 2
MIRT661391 RHCG Rh family C glycoprotein 2 2
MIRT662013 ZNF445 zinc finger protein 445 2 2
MIRT664012 LOH12CR1 BLOC-1 related complex subunit 5 2 2
MIRT664052 KIAA1551 KIAA1551 2 2
MIRT667065 PAOX polyamine oxidase 2 2
MIRT669160 CCNG1 cyclin G1 2 2
MIRT669650 ACSBG1 acyl-CoA synthetase bubblegum family member 1 2 2
MIRT673233 KLHDC8A kelch domain containing 8A 2 2
MIRT680480 ATP1B4 ATPase Na+/K+ transporting family member beta 4 2 2
MIRT683571 CARD8 caspase recruitment domain family member 8 2 2
MIRT683816 CBS cystathionine-beta-synthase 2 2
MIRT684555 ZNF708 zinc finger protein 708 2 2
MIRT685418 ACAD8 acyl-CoA dehydrogenase family member 8 2 2
MIRT686046 SLC5A5 solute carrier family 5 member 5 2 2
MIRT686135 B4GALT7 beta-1,4-galactosyltransferase 7 2 2
MIRT686799 SOX12 SRY-box 12 2 2
MIRT687477 NHLRC2 NHL repeat containing 2 2 2
MIRT687951 HHIP hedgehog interacting protein 2 2
MIRT688178 FRRS1 ferric chelate reductase 1 2 2
MIRT688300 FAM208A family with sequence similarity 208 member A 2 2
MIRT688895 C1GALT1 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 2 2
MIRT689199 ZNF574 zinc finger protein 574 2 2
MIRT690854 PVR poliovirus receptor 2 2
MIRT691258 ICOSLG inducible T-cell costimulator ligand 2 2
MIRT692923 EXOSC2 exosome component 2 2 2
MIRT693625 CENPL centromere protein L 2 2
MIRT694994 GGA2 golgi associated, gamma adaptin ear containing, ARF binding protein 2 2 2
MIRT695368 PHAX phosphorylated adaptor for RNA export 2 2
MIRT696626 WDR77 WD repeat domain 77 2 2
MIRT696686 APOC3 apolipoprotein C3 2 2
MIRT697364 ZNF394 zinc finger protein 394 2 2
MIRT697609 XIAP X-linked inhibitor of apoptosis 2 2
MIRT697733 USP6NL USP6 N-terminal like 2 2
MIRT697785 UBXN7 UBX domain protein 7 2 2
MIRT698357 TMEM127 transmembrane protein 127 2 2
MIRT698484 TIAL1 TIA1 cytotoxic granule associated RNA binding protein like 1 2 2
MIRT699855 SAR1B secretion associated Ras related GTPase 1B 2 2
MIRT704344 DCAF16 DDB1 and CUL4 associated factor 16 2 2
MIRT704595 CLN8 CLN8, transmembrane ER and ERGIC protein 2 2
MIRT705845 AHCY adenosylhomocysteinase 2 2
MIRT706305 NT5C2 5'-nucleotidase, cytosolic II 2 2
MIRT707090 TIMM50 translocase of inner mitochondrial membrane 50 2 2
MIRT707138 TRA2B transformer 2 beta homolog 2 2
MIRT707150 C17orf105 chromosome 17 open reading frame 105 2 2
MIRT707240 H6PD hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase 2 2
MIRT707352 XPNPEP3 X-prolyl aminopeptidase 3 2 2
MIRT707456 PPFIBP1 PPFIA binding protein 1 2 2
MIRT707499 AXL AXL receptor tyrosine kinase 2 2
MIRT707643 CRIPT CXXC repeat containing interactor of PDZ3 domain 2 2
MIRT707696 FAM118A family with sequence similarity 118 member A 2 2
MIRT707711 CDC6 cell division cycle 6 2 2
MIRT707822 TMEM170A transmembrane protein 170A 2 2
MIRT707963 PDK3 pyruvate dehydrogenase kinase 3 2 2
MIRT708002 NUDT4 nudix hydrolase 4 2 2
MIRT708031 MRPS14 mitochondrial ribosomal protein S14 2 2
MIRT708065 LIX1L limb and CNS expressed 1 like 2 2
MIRT708197 ANP32E acidic nuclear phosphoprotein 32 family member E 2 2
MIRT708206 AHSA2 activator of HSP90 ATPase homolog 2 2 2
MIRT711531 TRIP11 thyroid hormone receptor interactor 11 2 2
MIRT712637 RNF103-CHMP3 RNF103-CHMP3 readthrough 2 2
MIRT713697 CYB5R4 cytochrome b5 reductase 4 2 2
MIRT714244 WIPF2 WAS/WASL interacting protein family member 2 2 2
MIRT714397 FBXO31 F-box protein 31 2 2
MIRT714626 KIAA1143 KIAA1143 2 2
MIRT714911 CHMP3 charged multivesicular body protein 3 2 2
MIRT715568 EPHB4 EPH receptor B4 2 2
MIRT715846 SZT2 SZT2, KICSTOR complex subunit 2 2
MIRT716321 SIGLEC10 sialic acid binding Ig like lectin 10 2 2
MIRT718142 PALM paralemmin 2 2
MIRT720737 ELOVL7 ELOVL fatty acid elongase 7 2 2
MIRT722174 MRPS15 mitochondrial ribosomal protein S15 2 2
MIRT723223 FMNL3 formin like 3 2 2
MIRT723518 SIGLEC8 sialic acid binding Ig like lectin 8 2 2
MIRT724796 C1D C1D nuclear receptor corepressor 2 2
MIRT725280 OSTM1 osteopetrosis associated transmembrane protein 1 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4421 Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-4421 Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-4421 Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-4421 Docetaxel+Cisplatin+5-Fluorouracil sensitive tissue (hypopharyngeal squamous cell carcinoma)

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