pre-miRNA Information
pre-miRNA hsa-mir-873   
Genomic Coordinates chr9: 28888879 - 28888955
Synonyms MIRN873, hsa-mir-873, MIR873
Description Homo sapiens miR-873 stem-loop
Comment This sequence was identified as a miRNA candidate by Berezikov et al. using RAKE and MPSS techniques .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-873-3p
Sequence 46| GGAGACUGAUGAGUUCCCGGGA |67
Evidence Not_experimental
Experiments
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs760528397 3 dbSNP
rs773403294 9 dbSNP
rs1273846238 13 dbSNP
rs1339396073 15 dbSNP
rs1247999695 18 dbSNP
rs377380148 19 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol UGDH   
Synonyms GDH, UDP-GlcDH, UDPGDH, UGD
Description UDP-glucose 6-dehydrogenase
Transcript NM_001184700   
Other Transcripts NM_001184701 , NM_003359   
Expression
Putative miRNA Targets on UGDH
3'UTR of UGDH
(miRNA target sites are highlighted)
>UGDH|NM_001184700|3'UTR
   1 AGATTGCCATTTTTATTTGTGATTTTTTTTTTTTTTTTTTGGTACTTCAGGATAGCAAATATCTATCTGCTATTAAATGG
  81 TAAATGAACCAAGTGTTTTTTTTTGTTTTTTTTTTGAGACAGAGTCTCACTGTTGCCCAGGCTGGAGTGCAGTGGTGCAA
 161 TCTCGGCTCACTGCAAGCTCTGCTTCCCAGGTTCACGCCATTCTCCTGGCTCAGCCTCCCAAGTAGCTGGGACTACAGGC
 241 ACCCGCCACAGTGCCTGGCTAATTTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATGTGAGCCAGGATGGTCTCAATC
 321 TCCTGACCTTGTGAACCACCCGTCTCGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCACGCCTGGCCCATGAA
 401 CCAAGTGTTTTTAAGGAAACAAAACTATTTTTTTAATCATCAGATTTATACTAGCTATATGGATATTAGCATATCTGGTA
 481 ATTATGAATCTAGAATTTTTTTACATATTTTTATAATACTGTTAGCTCAGTTATTGGATGAGTGAAAGATAATCATGTTG
 561 GTTTTAATAGTGTCAATTTTTGTAAAATAAAAATTAAACTTCAAACTCTTTACTTTATAAATTGTCCATAGGCCACACTT
 641 TAATATCACATTATAAAGGGAAGGACAGTCTTCATTCCTCCTGGTTATTGGTTTGTTTGTCATTAAAGATATATTTTGAA
 721 TCCATGAAATTGCTATGCTAAACAGCCTTTACATGTATGGTCTGGTTAAAGTTCCTTTGTTCCTTTTGTTTTAATAAAAT
 801 GTGTCACTGATTTTTTAGCTCAAAATCATCACTGTTAATTTCCAGTCACCCCAAATATGGTTAAAAGATTTTTTTTTTAA
 881 TCATGAAGAGAAAATTAGTAGCATTTCTTTCTCTCCCCATTATTTATTGGTTTTCCTCACTAATCTTTTTTTTTTTAGTC
 961 CAAAAGCCAAAAATATTTATCTTGGTTTTACATTTTAATTTCCATTCTTAATTGTAATTTTTTTCTTTAAATAAGGAAAC
1041 CAATATAATCTCATGTATAAAAACTTAAATATTTTACAAGTTACATATAGCATCATTCTAAAATAAGAATTTTTTTTGTT
1121 TTCTGTCTGCTTTTTTCTTATGTCTCTTGTTGAGTTTTATATTTTCAGTGGTTATTTTTGCTTGTGTTAGATCATTATTA
1201 AAATATATCCAATGTCCCTTTGATACTTGTGCTCTGCTGAGAATGTACAGTTTGCATTAAACATCCCAGGTCTCATCCTT
1281 CAGGAATTTTGCAGTTCAATGAGAAGAGGGAGACAAATATAAAGATGAGGACAGAAGCATCTCTACAGATGAAAATTACA
1361 TAAATAAAACATTCTCCATCAACAACTAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' agggCCCUUGAGUAGUCAGAGg 5'
              |||||   : ||||||: 
Target 5' taaaGGGAA--GGACAGTCTTc 3'
654 - 673 134.00 -16.30
2
miRNA  3' agGGCCCUUGAGUAGUCAGAGg 5'
            ::| |||| || | ||||| 
Target 5' ccTTGTGAAC-CACCCGTCTCg 3'
327 - 347 131.00 -14.00
3
miRNA  3' agGGCCCU-UGAGUAGUCAGAGg 5'
            || ||| : || ||| |||| 
Target 5' agCCAGGATGGTC-TCAATCTCc 3'
302 - 323 127.00 -16.60
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN26584180 15 COSMIC
COSN20099966 23 COSMIC
COSN29051066 23 COSMIC
COSN30156189 51 COSMIC
COSN30558399 95 COSMIC
COSN30570231 95 COSMIC
COSN30648583 96 COSMIC
COSN14111246 104 COSMIC
COSN14111243 105 COSMIC
COSN20099963 105 COSMIC
COSN14111241 106 COSMIC
COSN8490715 118 COSMIC
COSN30143959 161 COSMIC
COSN1296865 214 COSMIC
COSN20099958 946 COSMIC
COSN6830315 1144 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1180965913 3 dbSNP
rs774232472 4 dbSNP
rs768851040 6 dbSNP
rs1251984053 14 dbSNP
rs780662298 15 dbSNP
rs770254620 18 dbSNP
rs746196826 19 dbSNP
rs1254167605 21 dbSNP
rs968229282 22 dbSNP
rs1487332458 24 dbSNP
rs1283838509 25 dbSNP
rs1215747324 26 dbSNP
rs781707095 27 dbSNP
rs756902603 28 dbSNP
rs1226395614 32 dbSNP
rs77838464 37 dbSNP
rs202227157 39 dbSNP
rs1235593127 41 dbSNP
rs200660972 41 dbSNP
rs56814765 41 dbSNP
rs60656244 41 dbSNP
rs747530231 41 dbSNP
rs750682668 41 dbSNP
rs757453539 41 dbSNP
rs761117281 41 dbSNP
rs777047292 41 dbSNP
rs796374269 41 dbSNP
rs796764519 41 dbSNP
rs878908036 41 dbSNP
rs879029271 41 dbSNP
rs879085598 41 dbSNP
rs1271823919 42 dbSNP
rs1293501722 42 dbSNP
rs1491349512 42 dbSNP
rs1239976242 43 dbSNP
rs1318828816 44 dbSNP
rs751292134 47 dbSNP
rs1416127760 50 dbSNP
rs1021582678 58 dbSNP
rs1286042029 73 dbSNP
rs1445355997 78 dbSNP
rs1231734839 79 dbSNP
rs1009738946 80 dbSNP
rs1476060326 83 dbSNP
rs1334415236 87 dbSNP
rs1162572684 89 dbSNP
rs372155217 90 dbSNP
rs911671935 94 dbSNP
rs375681686 95 dbSNP
rs559757240 96 dbSNP
rs74462207 104 dbSNP
rs1291880165 105 dbSNP
rs1313097994 105 dbSNP
rs1398866320 105 dbSNP
rs370656620 105 dbSNP
rs1218149361 106 dbSNP
rs397761986 106 dbSNP
rs398083020 107 dbSNP
rs1263029993 114 dbSNP
rs1432060980 115 dbSNP
rs1486803142 116 dbSNP
rs58175625 116 dbSNP
rs1347355404 117 dbSNP
rs577021038 119 dbSNP
rs1255172456 125 dbSNP
rs1419462411 129 dbSNP
rs931850463 131 dbSNP
rs1049471606 135 dbSNP
rs995703876 136 dbSNP
rs1376875376 139 dbSNP
rs1416704688 141 dbSNP
rs1165107562 142 dbSNP
rs756509423 143 dbSNP
rs1475912172 148 dbSNP
rs543016246 158 dbSNP
rs543695037 160 dbSNP
rs138137686 164 dbSNP
rs978094764 165 dbSNP
rs539247532 167 dbSNP
rs113565511 169 dbSNP
rs536209475 171 dbSNP
rs1350188621 174 dbSNP
rs1208921357 181 dbSNP
rs970769221 189 dbSNP
rs866935209 192 dbSNP
rs1468258276 196 dbSNP
rs774224917 203 dbSNP
rs937983361 205 dbSNP
rs1274046121 206 dbSNP
rs1439063488 208 dbSNP
rs1235314195 209 dbSNP
rs58958665 214 dbSNP
rs1174899310 221 dbSNP
rs1354817692 223 dbSNP
rs979541040 225 dbSNP
rs992301675 228 dbSNP
rs1300318323 231 dbSNP
rs1012800741 233 dbSNP
rs961179816 241 dbSNP
rs1294904360 242 dbSNP
rs959574210 244 dbSNP
rs113746940 245 dbSNP
rs914031358 246 dbSNP
rs139160141 251 dbSNP
rs1308348144 253 dbSNP
rs1229315214 257 dbSNP
rs1440630733 264 dbSNP
rs1395596048 269 dbSNP
rs1326202018 271 dbSNP
rs966236814 289 dbSNP
rs1019139894 295 dbSNP
rs1462660488 305 dbSNP
rs1466742924 311 dbSNP
rs1007787655 327 dbSNP
rs953734087 328 dbSNP
rs146689241 330 dbSNP
rs189575810 341 dbSNP
rs534375273 342 dbSNP
rs1036843999 345 dbSNP
rs890183216 346 dbSNP
rs1453592630 347 dbSNP
rs550036670 361 dbSNP
rs761878107 372 dbSNP
rs931770762 373 dbSNP
rs746663330 377 dbSNP
rs1276554720 379 dbSNP
rs777230044 386 dbSNP
rs1054063099 387 dbSNP
rs1044117607 388 dbSNP
rs536467992 392 dbSNP
rs567524250 394 dbSNP
rs946796428 402 dbSNP
rs913986496 408 dbSNP
rs936590442 410 dbSNP
rs758070221 411 dbSNP
rs1301895166 414 dbSNP
rs1486563262 428 dbSNP
rs1234143833 435 dbSNP
rs1372223992 438 dbSNP
rs1262097710 442 dbSNP
rs1477697308 448 dbSNP
rs1306049709 449 dbSNP
rs978040875 450 dbSNP
rs1388205863 454 dbSNP
rs988212555 456 dbSNP
rs142543281 478 dbSNP
rs1297169891 485 dbSNP
rs912099643 492 dbSNP
rs1296574539 495 dbSNP
rs1340167799 501 dbSNP
rs917966991 502 dbSNP
rs745613346 508 dbSNP
rs1376740772 516 dbSNP
rs148153514 521 dbSNP
rs752959753 530 dbSNP
rs1213909804 531 dbSNP
rs1284829227 535 dbSNP
rs1171718385 541 dbSNP
rs776603078 544 dbSNP
rs1433991096 547 dbSNP
rs1027145781 554 dbSNP
rs1239542057 557 dbSNP
rs115329965 567 dbSNP
rs1181776571 569 dbSNP
rs1409437341 583 dbSNP
rs1456491159 584 dbSNP
rs1156978981 606 dbSNP
rs1360005813 618 dbSNP
rs1195252419 624 dbSNP
rs1435528777 626 dbSNP
rs961600552 627 dbSNP
rs11544853 647 dbSNP
rs1315009803 647 dbSNP
rs552249257 649 dbSNP
rs532495796 663 dbSNP
rs1004521538 666 dbSNP
rs1046573 677 dbSNP
rs1481669694 683 dbSNP
rs1051907675 687 dbSNP
rs555032653 691 dbSNP
rs1348019156 695 dbSNP
rs1212495283 713 dbSNP
rs1276135908 720 dbSNP
rs1441040821 738 dbSNP
rs74535222 743 dbSNP
rs1233938724 753 dbSNP
rs1034888219 754 dbSNP
rs900280924 755 dbSNP
rs1379697560 757 dbSNP
rs796576230 762 dbSNP
rs1053610554 765 dbSNP
rs905125273 776 dbSNP
rs1282989564 777 dbSNP
rs1400419398 779 dbSNP
rs1413669937 784 dbSNP
rs1043701683 791 dbSNP
rs936527449 792 dbSNP
rs569187280 801 dbSNP
rs946692893 805 dbSNP
rs1444432995 817 dbSNP
rs1330600543 825 dbSNP
rs574953532 827 dbSNP
rs1305872961 831 dbSNP
rs1052469069 855 dbSNP
rs1391561417 858 dbSNP
rs371670655 859 dbSNP
rs1351839632 867 dbSNP
rs570636726 869 dbSNP
rs1303162394 879 dbSNP
rs879734036 879 dbSNP
rs1238161442 881 dbSNP
rs777135902 886 dbSNP
rs550898179 890 dbSNP
rs912026682 898 dbSNP
rs949347656 901 dbSNP
rs1451370023 905 dbSNP
rs367874306 916 dbSNP
rs186287281 922 dbSNP
rs3172642 926 dbSNP
rs959471445 927 dbSNP
rs1473679274 935 dbSNP
rs920858270 940 dbSNP
rs1255560870 946 dbSNP
rs558615963 949 dbSNP
rs1330032903 957 dbSNP
rs35551098 957 dbSNP
rs78496970 957 dbSNP
rs879186142 957 dbSNP
rs199867019 958 dbSNP
rs920026585 973 dbSNP
rs1271579407 977 dbSNP
rs1320430233 987 dbSNP
rs538723626 1000 dbSNP
rs1187298763 1010 dbSNP
rs1217260391 1021 dbSNP
rs1257946212 1030 dbSNP
rs973709971 1035 dbSNP
rs1212177211 1057 dbSNP
rs962675622 1076 dbSNP
rs974243182 1077 dbSNP
rs1194100332 1079 dbSNP
rs1265692847 1084 dbSNP
rs1486323759 1089 dbSNP
rs1476698325 1093 dbSNP
rs1260234465 1109 dbSNP
rs1203845646 1111 dbSNP
rs1015309696 1118 dbSNP
rs11544852 1118 dbSNP
rs1161394889 1118 dbSNP
rs1389314548 1118 dbSNP
rs1400839326 1118 dbSNP
rs1261647422 1123 dbSNP
rs961548919 1125 dbSNP
rs1330756593 1129 dbSNP
rs1015818602 1132 dbSNP
rs987049704 1133 dbSNP
rs955643452 1134 dbSNP
rs1398520616 1137 dbSNP
rs1277908632 1138 dbSNP
rs1356539425 1140 dbSNP
rs11931052 1149 dbSNP
rs960453719 1159 dbSNP
rs1288396480 1162 dbSNP
rs996270162 1165 dbSNP
rs1487400344 1171 dbSNP
rs1413630495 1193 dbSNP
rs1193252289 1199 dbSNP
rs1355472198 1212 dbSNP
rs900226665 1214 dbSNP
rs1336113027 1215 dbSNP
rs34844833 1219 dbSNP
rs1185311948 1223 dbSNP
rs1380414931 1232 dbSNP
rs1034825924 1239 dbSNP
rs1470172163 1244 dbSNP
rs181729245 1247 dbSNP
rs1450 1249 dbSNP
rs1000621202 1267 dbSNP
rs902359077 1271 dbSNP
rs969276440 1272 dbSNP
rs143808039 1274 dbSNP
rs1313121592 1276 dbSNP
rs1403289587 1281 dbSNP
rs1398220291 1296 dbSNP
rs547660133 1299 dbSNP
rs896421895 1300 dbSNP
rs1340450605 1302 dbSNP
rs1055113905 1307 dbSNP
rs1164402301 1308 dbSNP
rs1311498747 1310 dbSNP
rs1475584701 1319 dbSNP
rs892457784 1343 dbSNP
rs1281384508 1345 dbSNP
rs1484108836 1346 dbSNP
rs1052393869 1348 dbSNP
rs1255359370 1360 dbSNP
rs1008896823 1378 dbSNP
rs1370220445 1388 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 7358.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714644. RNA binding protein: AGO2. Condition:completeT1 "PAR-CLIP data was present in GSM714646. RNA binding protein: AGO2. Condition:mildMNase "PAR-CLIP data was present in GSM714647. RNA binding protein: AGO2. Condition:mildMNase ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 7358.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM1065667. RNA binding protein: AGO1. Condition:4-thiouridine ...

- Memczak S; Jens M; Elefsinioti A; Torti F; et al., 2013, Nature.

Article - Memczak S; Jens M; Elefsinioti A; Torti F; et al.
- Nature, 2013
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.
LinkOut: [PMID: 23446348]
Experimental Support 3 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293/HeLa
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1067869. RNA binding protein: AGO2. Condition:Ago2 IP-seq (asynchronous cells) HITS-CLIP data was present in GSM1067870. RNA binding protein: AGO2. Condition:Ago2 IP-seq (mitotic cells) ...

- Kishore S; Gruber AR; Jedlinski DJ; Syed et al., 2013, Genome biology.

Article - Kishore S; Gruber AR; Jedlinski DJ; Syed et al.
- Genome biology, 2013
BACKGROUND: In recent years, a variety of small RNAs derived from other RNAs with well-known functions such as tRNAs and snoRNAs, have been identified. The functional relevance of these RNAs is largely unknown. To gain insight into the complexity of snoRNA processing and the functional relevance of snoRNA-derived small RNAs, we sequence long and short RNAs, small RNAs that co-precipitate with the Argonaute 2 protein and RNA fragments obtained in photoreactive nucleotide-enhanced crosslinking and immunoprecipitation (PAR-CLIP) of core snoRNA-associated proteins. RESULTS: Analysis of these data sets reveals that many loci in the human genome reproducibly give rise to C/D box-like snoRNAs, whose expression and evolutionary conservation are typically less pronounced relative to the snoRNAs that are currently cataloged. We further find that virtually all C/D box snoRNAs are specifically processed inside the regions of terminal complementarity, retaining in the mature form only 4-5 nucleotides upstream of the C box and 2-5 nucleotides downstream of the D box. Sequencing of the total and Argonaute 2-associated populations of small RNAs reveals that despite their cellular abundance, C/D box-derived small RNAs are not efficiently incorporated into the Ago2 protein. CONCLUSIONS: We conclude that the human genome encodes a large number of snoRNAs that are processed along the canonical pathway and expressed at relatively low levels. Generation of snoRNA-derived processing products with alternative, particularly miRNA-like, functions appears to be uncommon.
LinkOut: [PMID: 23706177]
Experimental Support 4 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions Prostate Tissue
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in SRX1760630. RNA binding protein: AGO2. Condition:AGO-CLIP-22RV1_A ...

- Hamilton MP; Rajapakshe KI; Bader DA; Cerne et al., 2016, Neoplasia (New York, N.Y.).

Article - Hamilton MP; Rajapakshe KI; Bader DA; Cerne et al.
- Neoplasia (New York, N.Y.), 2016
MicroRNA (miRNA) deregulation in prostate cancer (PCa) contributes to PCa initiation and metastatic progression. To comprehensively define the cancer-associated changes in miRNA targeting and function in commonly studied models of PCa, we performed photoactivatable ribonucleoside-enhanced cross-linking immunoprecipitation of the Argonaute protein in a panel of PCa cell lines modeling different stages of PCa progression. Using this comprehensive catalogue of miRNA targets, we analyzed miRNA targeting on known drivers of PCa and examined tissue-specific and stage-specific pathway targeting by miRNAs. We found that androgen receptor is the most frequently targeted PCa oncogene and that miR-148a targets the largest number of known PCa drivers. Globally, tissue-specific and stage-specific changes in miRNA targeting are driven by homeostatic response to active oncogenic pathways. Our findings indicate that, even in advanced PCa, the miRNA pool adapts to regulate continuing alterations in the cancer genome to balance oncogenic molecular changes. These findings are important because they are the first to globally characterize miRNA changes in PCa and demonstrate how the miRNA target spectrum responds to staged tumorigenesis.
LinkOut: [PMID: 27292025]
CLIP-seq Support 1 for dataset GSM1067869
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293/HeLa / Ago2 IP-seq (asynchronous cells)
Location of target site ENST00000316423.6 | 3UTR | AGUCUCACUGUUGCCCAGGCUGG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23706177 / GSE43666
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1067870
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293/HeLa / Ago2 IP-seq (mitotic cells)
Location of target site ENST00000316423.6 | 3UTR | UCUCACUGUUGCCCAGG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23706177 / GSE43666
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM714644
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repA
Location of target site ENST00000316423.6 | 3UTR | AGUCUCACUGUUGCCCAGGCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM714646
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / mildMNase, repA
Location of target site ENST00000316423.6 | 3UTR | AGUCUCACUGUUGCCCAGGCUGGA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM714647
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / mildMNase, repB
Location of target site ENST00000316423.6 | 3UTR | AGUCUCACUGUUGCCCAGGCUGG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM1065667
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / 4-thiouridine, ML_MM_6
Location of target site ENST00000316423.6 | 3UTR | AGUCUCACUGUUGCCCAGGCUGG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
108 hsa-miR-873-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT081178 MIDN midnolin 2 4
MIRT109809 ZFX zinc finger protein, X-linked 2 4
MIRT242383 TMC5 transmembrane channel like 5 2 4
MIRT444003 METRN meteorin, glial cell differentiation regulator 2 4
MIRT444097 SEPHS1 selenophosphate synthetase 1 2 2
MIRT446158 RPL12 ribosomal protein L12 2 2
MIRT446859 SAMD9L sterile alpha motif domain containing 9 like 2 2
MIRT447275 FZD5 frizzled class receptor 5 2 2
MIRT447391 TMPRSS15 transmembrane protease, serine 15 2 2
MIRT448817 FKBP1A FK506 binding protein 1A 2 4
MIRT450582 HIST1H2BG histone cluster 1 H2B family member g 2 2
MIRT451776 USP36 ubiquitin specific peptidase 36 2 2
MIRT457961 ABCC5 ATP binding cassette subfamily C member 5 2 4
MIRT458424 KLHL38 kelch like family member 38 2 4
MIRT461383 SLFN12L schlafen family member 12 like 2 2
MIRT467793 SLC2A14 solute carrier family 2 member 14 2 2
MIRT476517 GABRB1 gamma-aminobutyric acid type A receptor beta1 subunit 2 2
MIRT480290 C7orf73 short transmembrane mitochondrial protein 1 2 4
MIRT482745 HES7 hes family bHLH transcription factor 7 2 10
MIRT483189 HIST1H2AH histone cluster 1 H2A family member h 2 6
MIRT486545 DCTN4 dynactin subunit 4 2 2
MIRT486581 ZNF619 zinc finger protein 619 2 2
MIRT492604 POLR3E RNA polymerase III subunit E 2 2
MIRT494130 DCAF7 DDB1 and CUL4 associated factor 7 2 6
MIRT496023 ZBED3 zinc finger BED-type containing 3 2 2
MIRT497121 NBEAL1 neurobeachin like 1 2 2
MIRT497400 TMEM245 transmembrane protein 245 2 2
MIRT501410 RANBP10 RAN binding protein 10 2 2
MIRT510947 PPTC7 PTC7 protein phosphatase homolog 2 6
MIRT512494 ARID2 AT-rich interaction domain 2 2 2
MIRT512595 ZNF783 zinc finger family member 783 2 2
MIRT512612 CNTN4 contactin 4 2 2
MIRT517808 UGDH UDP-glucose 6-dehydrogenase 2 6
MIRT520686 TMED7 transmembrane p24 trafficking protein 7 2 4
MIRT526179 HEPH hephaestin 2 2
MIRT532568 CSTF1 cleavage stimulation factor subunit 1 2 2
MIRT533979 TADA2A transcriptional adaptor 2A 2 2
MIRT538622 CCSER2 coiled-coil serine rich protein 2 2 4
MIRT539703 EIF3H eukaryotic translation initiation factor 3 subunit H 2 2
MIRT539806 GAPVD1 GTPase activating protein and VPS9 domains 1 2 2
MIRT540422 FAM83F family with sequence similarity 83 member F 2 2
MIRT540506 CXCL10 C-X-C motif chemokine ligand 10 2 2
MIRT540619 F2RL2 coagulation factor II thrombin receptor like 2 2 2
MIRT542423 ZNF331 zinc finger protein 331 2 2
MIRT542454 AKR7A2 aldo-keto reductase family 7 member A2 2 2
MIRT543383 CC2D2A coiled-coil and C2 domain containing 2A 2 2
MIRT544777 CSTF2T cleavage stimulation factor subunit 2 tau variant 2 4
MIRT544923 ERCC4 ERCC excision repair 4, endonuclease catalytic subunit 2 2
MIRT549768 ZNF611 zinc finger protein 611 2 4
MIRT551242 COLEC10 collectin subfamily member 10 2 2
MIRT560474 ENSA endosulfine alpha 2 2
MIRT569738 GPR173 G protein-coupled receptor 173 2 2
MIRT571297 CHCHD4 coiled-coil-helix-coiled-coil-helix domain containing 4 2 2
MIRT572345 CKAP2L cytoskeleton associated protein 2 like 2 2
MIRT573112 ERBB2IP erbb2 interacting protein 2 2
MIRT607744 ANGPT4 angiopoietin 4 2 2
MIRT607903 SPRYD4 SPRY domain containing 4 2 2
MIRT611744 SERPING1 serpin family G member 1 2 4
MIRT615101 BNC2 basonuclin 2 2 2
MIRT619124 CD40LG CD40 ligand 2 2
MIRT625572 ANKRD42 ankyrin repeat domain 42 2 2
MIRT629038 KLLN killin, p53-regulated DNA replication inhibitor 2 2
MIRT633986 SLC35E2 solute carrier family 35 member E2 2 2
MIRT635675 COX18 COX18, cytochrome c oxidase assembly factor 2 4
MIRT637471 DEFB105B defensin beta 105B 2 4
MIRT637503 DEFB105A defensin beta 105A 2 4
MIRT639735 MAP2K2 mitogen-activated protein kinase kinase 2 2 2
MIRT640730 C9orf64 chromosome 9 open reading frame 64 2 2
MIRT645364 C9orf47 chromosome 9 open reading frame 47 2 2
MIRT647938 RNF152 ring finger protein 152 2 2
MIRT649400 SH2D4A SH2 domain containing 4A 2 2
MIRT656860 KIN Kin17 DNA and RNA binding protein 2 2
MIRT663470 POFUT2 protein O-fucosyltransferase 2 2 2
MIRT663507 NKAPL NFKB activating protein like 2 4
MIRT667690 KNSTRN kinetochore localized astrin/SPAG5 binding protein 2 2
MIRT677403 PCNP PEST proteolytic signal containing nuclear protein 2 2
MIRT678682 SCUBE3 signal peptide, CUB domain and EGF like domain containing 3 2 2
MIRT678789 NUPL2 nucleoporin like 2 2 2
MIRT680649 KIAA1456 KIAA1456 2 2
MIRT682450 MTX3 metaxin 3 2 2
MIRT682740 CA6 carbonic anhydrase 6 2 2
MIRT684421 TUFT1 tuftelin 1 2 2
MIRT690535 TRAPPC2 trafficking protein particle complex 2 2 2
MIRT690595 C17orf105 chromosome 17 open reading frame 105 2 2
MIRT690771 PLA2G2C phospholipase A2 group IIC 2 2
MIRT692233 ALDH1B1 aldehyde dehydrogenase 1 family member B1 2 2
MIRT693667 MXRA7 matrix remodeling associated 7 2 2
MIRT695551 CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin 2 2
MIRT695870 C19orf52 translocase of inner mitochondrial membrane 29 2 2
MIRT696214 LYZ lysozyme 2 2
MIRT698368 TMED4 transmembrane p24 trafficking protein 4 2 2
MIRT700795 PHTF2 putative homeodomain transcription factor 2 2 2
MIRT701640 MYLK3 myosin light chain kinase 3 2 2
MIRT702989 HERPUD2 HERPUD family member 2 2 2
MIRT703627 FBXL3 F-box and leucine rich repeat protein 3 2 2
MIRT703783 FAM102B family with sequence similarity 102 member B 2 2
MIRT704293 DDX19B DEAD-box helicase 19B 2 2
MIRT704828 CDC73 cell division cycle 73 2 2
MIRT705014 CAMK2N1 calcium/calmodulin dependent protein kinase II inhibitor 1 2 2
MIRT708480 OLR1 oxidized low density lipoprotein receptor 1 2 2
MIRT710770 PHF7 PHD finger protein 7 2 2
MIRT718918 TRIM66 tripartite motif containing 66 2 2
MIRT720390 ZNF549 zinc finger protein 549 2 2
MIRT720593 TTC39C tetratricopeptide repeat domain 39C 2 2
MIRT723515 SIGLEC8 sialic acid binding Ig like lectin 8 2 2
MIRT724458 PRKX protein kinase, X-linked 2 2
MIRT737267 UMAD1 UBAP1-MVB12-associated (UMA) domain containing 1 3 0
MIRT737356 ZIC2 Zic family member 2 4 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-873 Dexamethasone approved 5743 Microarray adrenals and granulosa cells 24205079 2014 down-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-873 Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-873 Dabrafenib 44462760 NSC764134 approved sensitive cell line (A375)
hsa-mir-873 Cisplatin 5460033 NSC119875 approved resistant cell line (OE19)
hsa-mir-873 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-mir-873 Decitabine 451668 approved sensitive tissue (esopheageal cancer)
hsa-miR-873-3p Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-873-3p Cisplatin 5460033 NSC119875 approved resistant High Ovarian Cancer cell line (A2780)
hsa-miR-873-3p Cisplatin 5460033 NSC119875 approved sensitive High Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-873-3p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-873-3p Gefitinib 123631 NSC715055 approved sensitive cell line (PC9)
hsa-miR-873-3p Osimertinib 71496458 NSC779217 approved sensitive cell line (HCC827)
hsa-miR-873-3p Vemurafenib 42611257 NSC761431 approved sensitive cell line (451Lu)
hsa-miR-873-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-873-3p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-873-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-873-3p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-miR-873-3p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)
hsa-miR-873-3p Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)

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