pre-miRNA Information
pre-miRNA hsa-mir-1303   
Genomic Coordinates chr5: 154685776 - 154685861
Synonyms MIRN1303, hsa-mir-1303, MIR1303
Description Homo sapiens miR-1303 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-1303
Sequence 52| UUUAGAGACGGGGUCUUGCUCU |73
Evidence Experimental
Experiments Illumina
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 4 5 + 154685830 23291724, 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs370437195 6 dbSNP
rs1195001383 7 dbSNP
rs546614687 8 dbSNP
rs762579883 9 dbSNP
rs766041486 10 dbSNP
rs751079975 12 dbSNP
rs888516744 13 dbSNP
rs566454487 14 dbSNP
rs766973220 15 dbSNP
rs1474274822 17 dbSNP
rs753222192 18 dbSNP
rs1230907999 19 dbSNP
rs756552638 22 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol ABHD15   
Synonyms -
Description abhydrolase domain containing 15
Transcript NM_198147   
Expression
Putative miRNA Targets on ABHD15
3'UTR of ABHD15
(miRNA target sites are highlighted)
>ABHD15|NM_198147|3'UTR
   1 AAGACCTGGCCTGAGAACCCCCAAGTCCTGCAAAGAAAAACAGAGCTGGGCAAGGGGGAGTCCTGGAAAGATGGGGCGGA
  81 CTGAACAGAGGGAGCTCCAGCTCTGTGCTCCTCATTCAGTCCCTCTCTCTTAAATTGGTGCCTTGAAAGAGAAGGAACGT
 161 CCTGCGAGCCTGCACTCACTTCATCCTCAGCAGAACTCCTGCCTGGCCTCTGCTCAACATATCCCTACTCATCCGGTCAG
 241 CAGCGGCGCGTTCCAGTCACTGTCACCTGTCACTGACATCACAAGCCAAAGGATAGCACTTTTTCAATCCATGGACTCAG
 321 GAGAAAATGCCCTCTTACTGGCAGTGGCTAGAGGGATGAGACGTTTGTGTATGTCACTGGGCAGTGACCCCGATTCTCAA
 401 GCTGGAGCCATTTGATGTCATGAGGACAGGATGTTTGTGTCTCGGCCCCACTTCCCTCATTTGCTCTGTGGTTGTGGCGC
 481 CCTGCTTTGACCGAATGCTCTGGCAACTGCGGCAGCAGGCTTGTGTGTGTGAGAAGGGCGGCAGAGGCAGTGGGGCTGGC
 561 TCGCTGAGGGCTGAGCAGGTAGAGAATGTGAATGTCCATCTCAAGGAATGCGAAGTTCCAATCTCTCAGAGGAGCTCTGC
 641 AAGTCTCAGCTAGGAATGGGGCTGATCTGGCCCCCAAGCCTCACTGGAGAGATCCCAAGGGTATTTTACAAATAGGAAGC
 721 GCTCTCATGCAGGATCTGAGGGCTTTGCTAGACCATGGTTCAAGGAGTCAGAATCTTGGCTACCCTACATGCTCCCTCTG
 801 GCACCATTTCAGGGGATTACTCCAGAGAGCTGCAGCCAGAACTGTTTATCTCCTGAGATATGGACTTTCTCTAAGTCAGG
 881 AAAAGCACAAACCTCATAACTTAGGTGTTTTCTGGTTGGTTGCTCCCTTTTCTGATCCTACTACTGGCCTCTCCCTTTCC
 961 AGAGCCAGGAGACACATCTGGGACCAGAGGAAACAAAAGCACCAAGAGGTTGACTAGAGCTGACCAGTGATTTACAAATA
1041 TTTCATATTCCAATGCTTCGTCTGCTCAATTATTCAAAAGGCCATCCCTGTAAAGGCAGAAAAGCTTCCTCTTAGATCTG
1121 GCCACTCAGCAAATAAGTGGGTATTTGGTTTTATGAAGAATAATGCTGAGGACTAGAGATATAGTATATCAGAGATAATA
1201 TATAGTATACAGGTTGATCTAAATATTCTGGTTTGGATTAGGCAATTAAAATTTTTTTGGCAACAGGACATATGTTTCCA
1281 TGTGTTGCTAAGATTCAAAAACTTTGCCCTGAAGTTTTATTTTAATCGTCATTGAGAAAGAGGGCTCCTGTTCTGACCTC
1361 AAAAACAGCAAAGCTGTTGTAAAGAAGAGAGCTGCTTATACGAAAACCCACATTCCAAGACTTGGTATAAGGTATTCCTG
1441 AGGCCTTGATTTCAGGTTTGGATAATCTTGCCCCAGATTCTAGATCTTGTTCTTCTAGATCAAATCAGAAGAAACTTTGA
1521 AATAACTCCAAGAATCTGCACTGAAATGTAGACAGCACTCGATAATCTAAGGGACATTATCTTGTTGTGAAAAATTATCT
1601 CCCTCCTGGCTGGGAGCGGTGGCACACACCTATAATCTCAGCACTTTGGGAGGCCGAGGTGGGTGGATCACGAGGTCAGG
1681 AGATCGAGACCATCCTGGCTAACACAGTGAAACCTCATCTCTACTAAAAATACAAAAAATTAGCCGGGCGTGGTAGCGGG
1761 TGCCTGTAATCCCAGTTACTCAGGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGGAGGCGGAGCTTGCAGTGAGCTGAG
1841 ATCGCACCACTGCACTCCAGCCTGGGCGACAGAGTAAGACTGTGTTTCAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' ucUCGUUCUGGGGCAGAGAUuu 5'
            ||::| |||:| ||||||  
Target 5' acAGTGAAACCTCATCTCTAct 3'
1704 - 1725 152.00 -13.00
2
miRNA  3' ucucguUCUGGGGCAGAGAUUu 5'
                :|||::  ||||||| 
Target 5' agatatGGACTT--TCTCTAAg 3'
856 - 875 148.00 -11.90
3
miRNA  3' ucUCGUUCUGGGGCAGAGAUUu 5'
            ||:|||||: :||:|| || 
Target 5' agAGTAAGACTGTGTTTCAAAa 3'
1871 - 1892 132.00 -23.20
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31553465 47 COSMIC
COSN30153527 83 COSMIC
COSN21665679 201 COSMIC
COSN22509291 502 COSMIC
COSN21136147 510 COSMIC
COSN8834228 688 COSMIC
COSN8241429 696 COSMIC
COSN26576133 788 COSMIC
COSN26508839 837 COSMIC
COSN31540796 882 COSMIC
COSN26263414 991 COSMIC
COSN31488032 1022 COSMIC
COSN1716150 1059 COSMIC
COSN5415248 1060 COSMIC
COSN22410441 1192 COSMIC
COSN16865725 1234 COSMIC
COSN22737545 1508 COSMIC
COSN25164858 1992 COSMIC
COSN25167694 1994 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs539307 1 dbSNP
rs542605305 3 dbSNP
rs777214610 5 dbSNP
rs1430410976 7 dbSNP
rs1344083781 10 dbSNP
rs770873228 12 dbSNP
rs1411921576 13 dbSNP
rs375930056 17 dbSNP
rs773280096 18 dbSNP
rs1408143977 19 dbSNP
rs1360944829 24 dbSNP
rs1177477553 29 dbSNP
rs1409440188 30 dbSNP
rs772479385 35 dbSNP
rs747952644 36 dbSNP
rs530464744 44 dbSNP
rs1320739974 46 dbSNP
rs768584286 47 dbSNP
rs1390276632 49 dbSNP
rs1393785827 51 dbSNP
rs1334127386 53 dbSNP
rs915424556 54 dbSNP
rs375448386 55 dbSNP
rs558735304 60 dbSNP
rs1286875554 71 dbSNP
rs1479239656 75 dbSNP
rs1328848978 77 dbSNP
rs150377769 78 dbSNP
rs932618614 79 dbSNP
rs921291013 82 dbSNP
rs1193708004 86 dbSNP
rs1445924523 87 dbSNP
rs1270250692 92 dbSNP
rs1199920799 94 dbSNP
rs1256895450 106 dbSNP
rs1442968155 107 dbSNP
rs1189896766 110 dbSNP
rs1249366197 113 dbSNP
rs1472134532 121 dbSNP
rs1159529491 125 dbSNP
rs1413669290 131 dbSNP
rs1464146291 137 dbSNP
rs184261567 139 dbSNP
rs1402238803 141 dbSNP
rs553114867 152 dbSNP
rs1398306903 153 dbSNP
rs1259507030 155 dbSNP
rs748350698 157 dbSNP
rs541259258 158 dbSNP
rs573969692 159 dbSNP
rs910182691 163 dbSNP
rs1345720218 165 dbSNP
rs191343692 166 dbSNP
rs1329588597 173 dbSNP
rs1232758391 197 dbSNP
rs1256668911 201 dbSNP
rs537760199 208 dbSNP
rs569906411 211 dbSNP
rs954440481 220 dbSNP
rs1272381743 224 dbSNP
rs776421724 234 dbSNP
rs983245157 235 dbSNP
rs950587192 236 dbSNP
rs1325915967 241 dbSNP
rs1197633953 244 dbSNP
rs539132947 245 dbSNP
rs140915849 247 dbSNP
rs112075008 248 dbSNP
rs546795176 249 dbSNP
rs368582873 250 dbSNP
rs895566743 274 dbSNP
rs572235494 275 dbSNP
rs1386437874 281 dbSNP
rs906564858 283 dbSNP
rs1031874088 284 dbSNP
rs1332974930 285 dbSNP
rs1042834857 288 dbSNP
rs1295376961 296 dbSNP
rs1425247912 297 dbSNP
rs757954589 309 dbSNP
rs1170967696 312 dbSNP
rs186921663 314 dbSNP
rs904713078 316 dbSNP
rs945497673 319 dbSNP
rs1370843078 320 dbSNP
rs1208943627 328 dbSNP
rs1267581563 337 dbSNP
rs1043303900 341 dbSNP
rs915370719 342 dbSNP
rs1053964264 346 dbSNP
rs1450645649 362 dbSNP
rs377376104 363 dbSNP
rs987763323 368 dbSNP
rs1294380242 374 dbSNP
rs1393117141 380 dbSNP
rs954512705 381 dbSNP
rs548965638 386 dbSNP
rs1320008362 389 dbSNP
rs1442879201 391 dbSNP
rs918949100 392 dbSNP
rs530835646 398 dbSNP
rs1297637431 403 dbSNP
rs1319751653 408 dbSNP
rs563108582 414 dbSNP
rs530344002 422 dbSNP
rs1041053125 426 dbSNP
rs770955054 429 dbSNP
rs11867220 432 dbSNP
rs1206367827 438 dbSNP
rs963107320 443 dbSNP
rs139619101 444 dbSNP
rs878868351 444 dbSNP
rs1170741969 445 dbSNP
rs1423643984 446 dbSNP
rs878994975 450 dbSNP
rs1012702977 453 dbSNP
rs1268470550 461 dbSNP
rs908615776 466 dbSNP
rs958558147 469 dbSNP
rs1247113040 471 dbSNP
rs1432942556 471 dbSNP
rs1290614063 474 dbSNP
rs532846597 478 dbSNP
rs559048065 479 dbSNP
rs145663736 488 dbSNP
rs1402895998 489 dbSNP
rs973260899 492 dbSNP
rs1042393199 493 dbSNP
rs1267099350 496 dbSNP
rs1009619096 498 dbSNP
rs1217282863 503 dbSNP
rs1235190194 505 dbSNP
rs970004409 506 dbSNP
rs371612364 511 dbSNP
rs567940881 519 dbSNP
rs1053911734 523 dbSNP
rs573857262 529 dbSNP
rs943498042 533 dbSNP
rs992501033 536 dbSNP
rs960005798 539 dbSNP
rs555933714 540 dbSNP
rs745423966 549 dbSNP
rs778593044 550 dbSNP
rs543732007 554 dbSNP
rs1357208234 560 dbSNP
rs910750769 562 dbSNP
rs551334573 563 dbSNP
rs530472768 567 dbSNP
rs1164446707 576 dbSNP
rs1311040814 578 dbSNP
rs1211506850 582 dbSNP
rs1444718272 584 dbSNP
rs968842698 596 dbSNP
rs1482309430 599 dbSNP
rs1021809103 611 dbSNP
rs756863268 612 dbSNP
rs1471284792 617 dbSNP
rs564909300 621 dbSNP
rs1424620532 623 dbSNP
rs900079295 628 dbSNP
rs1433840835 634 dbSNP
rs1441540431 638 dbSNP
rs1238529432 639 dbSNP
rs1377172768 660 dbSNP
rs1427684940 661 dbSNP
rs34394684 662 dbSNP
rs569624108 664 dbSNP
rs1307215516 672 dbSNP
rs1041727592 678 dbSNP
rs971748911 680 dbSNP
rs941742392 681 dbSNP
rs1195246575 682 dbSNP
rs576691209 694 dbSNP
rs908949480 700 dbSNP
rs1008215718 703 dbSNP
rs958504387 712 dbSNP
rs1035545416 720 dbSNP
rs887126010 721 dbSNP
rs1047107490 741 dbSNP
rs931406271 742 dbSNP
rs920390676 753 dbSNP
rs1219729771 755 dbSNP
rs1211646425 756 dbSNP
rs753443818 758 dbSNP
rs1037496698 761 dbSNP
rs1478424527 763 dbSNP
rs1195600993 779 dbSNP
rs1020652318 782 dbSNP
rs756429604 783 dbSNP
rs915819610 793 dbSNP
rs993179711 798 dbSNP
rs116832636 806 dbSNP
rs539870964 809 dbSNP
rs1420030547 813 dbSNP
rs1411442013 815 dbSNP
rs75833025 818 dbSNP
rs893834951 827 dbSNP
rs74484133 842 dbSNP
rs924284472 846 dbSNP
rs977134407 848 dbSNP
rs753402206 849 dbSNP
rs1379820666 852 dbSNP
rs1032413510 854 dbSNP
rs968457352 860 dbSNP
rs566175217 861 dbSNP
rs1021422801 863 dbSNP
rs1007660962 866 dbSNP
rs889245298 901 dbSNP
rs755363222 903 dbSNP
rs554348569 909 dbSNP
rs1469096331 914 dbSNP
rs1019846177 919 dbSNP
rs115565555 925 dbSNP
rs1464486034 927 dbSNP
rs753066668 928 dbSNP
rs1037046953 937 dbSNP
rs763473002 941 dbSNP
rs1242596914 944 dbSNP
rs567301581 946 dbSNP
rs549180509 947 dbSNP
rs1161174328 948 dbSNP
rs1461655747 954 dbSNP
rs991176962 955 dbSNP
rs1385891437 964 dbSNP
rs556867254 972 dbSNP
rs760433407 988 dbSNP
rs937093004 999 dbSNP
rs928422637 1000 dbSNP
rs981287983 1007 dbSNP
rs967653288 1008 dbSNP
rs1235428053 1010 dbSNP
rs1176372337 1013 dbSNP
rs765307222 1017 dbSNP
rs1328628340 1021 dbSNP
rs1020181474 1023 dbSNP
rs1263900156 1029 dbSNP
rs1448668523 1037 dbSNP
rs990095033 1044 dbSNP
rs995506922 1053 dbSNP
rs183331853 1060 dbSNP
rs1032347815 1069 dbSNP
rs1456336501 1071 dbSNP
rs1007615495 1072 dbSNP
rs889198752 1074 dbSNP
rs1045156745 1081 dbSNP
rs140593140 1082 dbSNP
rs1356575129 1093 dbSNP
rs1416973691 1095 dbSNP
rs532808526 1104 dbSNP
rs1286741066 1127 dbSNP
rs1350137469 1128 dbSNP
rs948564807 1130 dbSNP
rs997678620 1137 dbSNP
rs898019304 1142 dbSNP
rs1342949077 1143 dbSNP
rs1036546221 1145 dbSNP
rs1220422625 1161 dbSNP
rs942307359 1164 dbSNP
rs558935684 1165 dbSNP
rs1285578307 1175 dbSNP
rs544745314 1182 dbSNP
rs1249296592 1190 dbSNP
rs1418152507 1202 dbSNP
rs1348965761 1205 dbSNP
rs1057016569 1210 dbSNP
rs762039818 1213 dbSNP
rs1172542443 1223 dbSNP
rs1376567169 1245 dbSNP
rs938603917 1251 dbSNP
rs1437069406 1252 dbSNP
rs1370279096 1259 dbSNP
rs572637945 1259 dbSNP
rs529007690 1265 dbSNP
rs1344529363 1266 dbSNP
rs1300690110 1267 dbSNP
rs1055394284 1273 dbSNP
rs767965965 1274 dbSNP
rs35456552 1280 dbSNP
rs977080796 1285 dbSNP
rs947069073 1292 dbSNP
rs914310953 1302 dbSNP
rs1329459650 1305 dbSNP
rs975591783 1308 dbSNP
rs781622278 1327 dbSNP
rs1348543020 1328 dbSNP
rs1236315079 1334 dbSNP
rs937035001 1336 dbSNP
rs928400057 1340 dbSNP
rs1020210453 1342 dbSNP
rs1196083848 1343 dbSNP
rs1252185410 1348 dbSNP
rs987032704 1349 dbSNP
rs945887179 1350 dbSNP
rs913069143 1361 dbSNP
rs1455980719 1375 dbSNP
rs990042511 1393 dbSNP
rs367582873 1401 dbSNP
rs951630478 1402 dbSNP
rs1390023371 1406 dbSNP
rs1462788530 1408 dbSNP
rs911176523 1412 dbSNP
rs757106173 1415 dbSNP
rs1025888224 1428 dbSNP
rs995456070 1429 dbSNP
rs986128343 1437 dbSNP
rs1386388824 1439 dbSNP
rs1326666278 1443 dbSNP
rs953527246 1453 dbSNP
rs1030405564 1454 dbSNP
rs998024969 1455 dbSNP
rs562110096 1464 dbSNP
rs544029562 1467 dbSNP
rs1023698890 1472 dbSNP
rs1015050296 1476 dbSNP
rs1012756734 1485 dbSNP
rs1398941903 1486 dbSNP
rs1427009015 1487 dbSNP
rs1353855225 1489 dbSNP
rs1176945270 1492 dbSNP
rs576641539 1495 dbSNP
rs1469418443 1503 dbSNP
rs564846583 1512 dbSNP
rs567109666 1515 dbSNP
rs1429577623 1518 dbSNP
rs938569179 1524 dbSNP
rs1246582469 1525 dbSNP
rs903095641 1534 dbSNP
rs1041686182 1543 dbSNP
rs947018186 1552 dbSNP
rs1215697046 1553 dbSNP
rs1396866680 1555 dbSNP
rs1432950854 1560 dbSNP
rs1318510339 1561 dbSNP
rs1361207412 1571 dbSNP
rs1445814064 1572 dbSNP
rs1281141561 1577 dbSNP
rs1001188507 1581 dbSNP
rs774651438 1589 dbSNP
rs1322348999 1596 dbSNP
rs776777982 1608 dbSNP
rs1273396694 1609 dbSNP
rs1045456365 1615 dbSNP
rs945804172 1617 dbSNP
rs768497351 1618 dbSNP
rs1254583115 1621 dbSNP
rs1475082048 1633 dbSNP
rs760430497 1636 dbSNP
rs546210935 1642 dbSNP
rs912352381 1646 dbSNP
rs1158511132 1648 dbSNP
rs775550778 1655 dbSNP
rs1337098306 1661 dbSNP
rs1469102431 1664 dbSNP
rs935858800 1667 dbSNP
rs1353376546 1668 dbSNP
rs951576793 1672 dbSNP
rs1025832410 1675 dbSNP
rs974312783 1678 dbSNP
rs962654136 1685 dbSNP
rs1024067580 1686 dbSNP
rs1305692720 1688 dbSNP
rs1420276124 1690 dbSNP
rs1186053600 1700 dbSNP
rs1485150691 1712 dbSNP
rs572430168 1715 dbSNP
rs1485577670 1719 dbSNP
rs1212067065 1741 dbSNP
rs1245544678 1745 dbSNP
rs528213624 1746 dbSNP
rs896561730 1749 dbSNP
rs1035147016 1750 dbSNP
rs1002695434 1755 dbSNP
rs554211624 1757 dbSNP
rs903043345 1761 dbSNP
rs1313267121 1762 dbSNP
rs1376989527 1765 dbSNP
rs7218963 1769 dbSNP
rs1297245560 1773 dbSNP
rs962444298 1776 dbSNP
rs1014994615 1781 dbSNP
rs1006340046 1782 dbSNP
rs1347823416 1786 dbSNP
rs947294728 1794 dbSNP
rs1381166066 1804 dbSNP
rs1315657859 1805 dbSNP
rs1204144422 1812 dbSNP
rs1451893567 1813 dbSNP
rs892762817 1814 dbSNP
rs1403626495 1815 dbSNP
rs535923080 1820 dbSNP
rs574891271 1821 dbSNP
rs1453740511 1825 dbSNP
rs912283942 1829 dbSNP
rs745801414 1830 dbSNP
rs559212334 1833 dbSNP
rs1355358905 1835 dbSNP
rs1169777144 1837 dbSNP
rs1034551211 1843 dbSNP
rs1354772100 1844 dbSNP
rs555254126 1845 dbSNP
rs930119625 1846 dbSNP
rs918765841 1847 dbSNP
rs1369535222 1851 dbSNP
rs1444635351 1855 dbSNP
rs1306230713 1856 dbSNP
rs542399683 1861 dbSNP
rs1274109082 1862 dbSNP
rs573541132 1863 dbSNP
rs1219580323 1864 dbSNP
rs916879495 1865 dbSNP
rs991222056 1867 dbSNP
rs1468960459 1868 dbSNP
rs1194226128 1870 dbSNP
rs1009939670 1875 dbSNP
rs960769473 1877 dbSNP
rs1474355441 1888 dbSNP
rs78302945 1890 dbSNP
rs1035497299 1895 dbSNP
rs891549773 1896 dbSNP
rs1054230898 1901 dbSNP
rs1167140638 1901 dbSNP
rs548284467 1901 dbSNP
rs999629318 1901 dbSNP
rs935807865 1902 dbSNP
rs889638932 1909 dbSNP
rs1245114706 1911 dbSNP
rs1325232334 1915 dbSNP
rs1380554817 1930 dbSNP
rs1049644975 1933 dbSNP
rs1364510705 1937 dbSNP
rs1231763136 1945 dbSNP
rs933906813 1946 dbSNP
rs1335600747 1949 dbSNP
rs1215654793 1950 dbSNP
rs1282189587 1958 dbSNP
rs1311117807 1960 dbSNP
rs1192307610 1961 dbSNP
rs1242547420 1965 dbSNP
rs1476266967 1966 dbSNP
rs1185415868 1970 dbSNP
rs537276798 1977 dbSNP
rs1461602128 1987 dbSNP
rs1374240851 1989 dbSNP
rs569845757 1990 dbSNP
rs1400699809 1991 dbSNP
rs551299677 1994 dbSNP
rs967175029 1996 dbSNP
rs1319555608 2007 dbSNP
rs923264477 2009 dbSNP
rs1297834730 2015 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 116236.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM1065667. RNA binding protein: AGO1. Condition:4-thiouridine ...

- Memczak S; Jens M; Elefsinioti A; Torti F; et al., 2013, Nature.

Article - Memczak S; Jens M; Elefsinioti A; Torti F; et al.
- Nature, 2013
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.
LinkOut: [PMID: 23446348]
CLIP-seq Support 1 for dataset GSM1065667
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / 4-thiouridine, ML_MM_6
Location of target site ENST00000307201.4 | 3UTR | UCUCUACUAAAAACACAAAAUUAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28260 Renal cortex and medulla -0.717 2.9e-3 -0.720 2.8e-3 13 Click to see details
GSE28544 Breast cancer -0.452 1.3e-2 -0.458 1.2e-2 24 Click to see details
GSE42095 Differentiated embryonic stem cells -0.443 1.7e-2 -0.432 2.0e-2 23 Click to see details
GSE38226 Liver fibrosis 0.384 4.3e-2 0.403 3.5e-2 21 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.195 1.8e-1 -0.342 4.7e-2 25 Click to see details
GSE32688 Pancreatic cancer -0.165 1.8e-1 -0.236 9.7e-2 32 Click to see details
GSE26953 Aortic valvular endothelial cells 0.176 2.1e-1 0.075 3.6e-1 24 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
186 hsa-miR-1303 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT035871 SOAT1 sterol O-acyltransferase 1 1 1
MIRT035872 FHOD3 formin homology 2 domain containing 3 1 1
MIRT035873 RPL7A ribosomal protein L7a 1 1
MIRT035874 NCAPD2 non-SMC condensin I complex subunit D2 1 1
MIRT035875 RPS8 ribosomal protein S8 1 1
MIRT035876 AHNAK AHNAK nucleoprotein 1 1
MIRT035877 ACTB actin beta 1 1
MIRT035878 DEF8 differentially expressed in FDCP 8 homolog 1 1
MIRT035879 MET MET proto-oncogene, receptor tyrosine kinase 1 1
MIRT035880 MED13 mediator complex subunit 13 1 1
MIRT035881 FAT3 FAT atypical cadherin 3 1 1
MIRT035882 HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 1 1
MIRT035883 RPS16 ribosomal protein S16 1 1
MIRT035884 CDK6 cyclin dependent kinase 6 1 1
MIRT035885 GEMIN5 gem nuclear organelle associated protein 5 1 1
MIRT035886 PITRM1 pitrilysin metallopeptidase 1 1 1
MIRT035887 PRRC2A proline rich coiled-coil 2A 1 1
MIRT035888 KIAA0226 RUN and cysteine rich domain containing beclin 1 interacting protein 1 1
MIRT035889 MLLT6 MLLT6, PHD finger containing 1 1
MIRT035890 EIF3I eukaryotic translation initiation factor 3 subunit I 1 1
MIRT035891 FASN fatty acid synthase 1 1
MIRT035892 LEPREL4 prolyl 3-hydroxylase family member 4 (non-enzymatic) 1 1
MIRT035893 HSCB HscB mitochondrial iron-sulfur cluster cochaperone 1 1
MIRT035894 PSME4 proteasome activator subunit 4 1 1
MIRT035895 FRS2 fibroblast growth factor receptor substrate 2 1 1
MIRT035896 ZNF264 zinc finger protein 264 1 1
MIRT035897 HYLS1 HYLS1, centriolar and ciliogenesis associated 1 1
MIRT035898 USP54 ubiquitin specific peptidase 54 1 1
MIRT035899 L1TD1 LINE1 type transposase domain containing 1 1 1
MIRT035900 OR51E2 olfactory receptor family 51 subfamily E member 2 1 1
MIRT053762 CLDN18 claudin 18 3 1
MIRT060730 RPS3 ribosomal protein S3 2 2
MIRT083986 RAB22A RAB22A, member RAS oncogene family 2 2
MIRT098550 TBPL1 TATA-box binding protein like 1 2 6
MIRT134983 TWF1 twinfilin actin binding protein 1 2 4
MIRT136956 FNDC3A fibronectin type III domain containing 3A 2 2
MIRT222065 PURB purine rich element binding protein B 2 2
MIRT239574 UBN2 ubinuclein 2 2 4
MIRT261820 BUB3 BUB3, mitotic checkpoint protein 2 2
MIRT264698 C11ORF57 chromosome 11 open reading frame 57 2 4
MIRT308476 GXYLT2 glucoside xylosyltransferase 2 2 2
MIRT377481 NDUFB5 NADH:ubiquinone oxidoreductase subunit B5 2 2
MIRT442304 NEU3 neuraminidase 3 2 2
MIRT446083 SLC30A10 solute carrier family 30 member 10 2 2
MIRT449606 PRPF4 pre-mRNA processing factor 4 2 2
MIRT453767 NUCB1 nucleobindin 1 2 10
MIRT455603 SRSF3 serine and arginine rich splicing factor 3 2 2
MIRT455913 KIF2C kinesin family member 2C 2 2
MIRT460091 ZYG11B zyg-11 family member B, cell cycle regulator 2 4
MIRT460866 UBE2S ubiquitin conjugating enzyme E2 S 2 2
MIRT461339 NUP133 nucleoporin 133 2 2
MIRT463769 YOD1 YOD1 deubiquitinase 2 2
MIRT466368 THAP1 THAP domain containing 1 2 4
MIRT467168 SPTY2D1 SPT2 chromatin protein domain containing 1 2 2
MIRT468703 SDHD succinate dehydrogenase complex subunit D 2 2
MIRT469122 RNF126 ring finger protein 126 2 2
MIRT472426 NCBP2 nuclear cap binding protein subunit 2 2 4
MIRT479420 CDKN1B cyclin dependent kinase inhibitor 1B 2 8
MIRT484260 FAM177A1 family with sequence similarity 177 member A1 2 2
MIRT485468 IL6ST interleukin 6 signal transducer 2 10
MIRT490237 H2AFZ H2A histone family member Z 2 6
MIRT491002 ATF7IP activating transcription factor 7 interacting protein 2 2
MIRT492127 SUMO2 small ubiquitin-like modifier 2 2 2
MIRT499169 RBPJL recombination signal binding protein for immunoglobulin kappa J region like 2 2
MIRT499825 PCSK9 proprotein convertase subtilisin/kexin type 9 2 8
MIRT501794 NRAS NRAS proto-oncogene, GTPase 2 2
MIRT503441 GINS4 GINS complex subunit 4 2 4
MIRT503688 MAVS mitochondrial antiviral signaling protein 2 5
MIRT506926 IGDCC4 immunoglobulin superfamily DCC subclass member 4 2 6
MIRT511430 HOXA10 homeobox A10 2 6
MIRT512415 LAYN layilin 2 4
MIRT513791 NIPAL3 NIPA like domain containing 3 2 4
MIRT516163 NTMT1 N-terminal Xaa-Pro-Lys N-methyltransferase 1 2 4
MIRT516513 PARK2 parkin RBR E3 ubiquitin protein ligase 2 2
MIRT516915 HINFP histone H4 transcription factor 2 2
MIRT517102 NDUFV3 NADH:ubiquinone oxidoreductase subunit V3 2 2
MIRT517350 NLRP9 NLR family pyrin domain containing 9 2 2
MIRT518019 ABHD15 abhydrolase domain containing 15 2 2
MIRT520945 SRSF10 serine and arginine rich splicing factor 10 2 2
MIRT525250 RNF213 ring finger protein 213 2 2
MIRT530634 PPIC peptidylprolyl isomerase C 2 4
MIRT530671 CHRNB1 cholinergic receptor nicotinic beta 1 subunit 2 4
MIRT531563 ILDR1 immunoglobulin like domain containing receptor 1 2 2
MIRT538205 CYR61 cysteine rich angiogenic inducer 61 2 2
MIRT538419 COLEC10 collectin subfamily member 10 2 2
MIRT541964 ZNF485 zinc finger protein 485 2 2
MIRT543088 KNSTRN kinetochore localized astrin/SPAG5 binding protein 2 2
MIRT543257 ZNF662 zinc finger protein 662 2 2
MIRT543589 KIAA1549 KIAA1549 2 2
MIRT543955 RNF20 ring finger protein 20 2 2
MIRT544043 C9orf64 chromosome 9 open reading frame 64 2 4
MIRT548064 GIGYF1 GRB10 interacting GYF protein 1 2 2
MIRT548240 FBXW7 F-box and WD repeat domain containing 7 2 2
MIRT548442 EIF1AX eukaryotic translation initiation factor 1A, X-linked 2 2
MIRT548623 DAZAP1 DAZ associated protein 1 2 4
MIRT548770 COLEC12 collectin subfamily member 12 2 2
MIRT549506 HDDC2 HD domain containing 2 2 4
MIRT551924 AKAP8 A-kinase anchoring protein 8 2 4
MIRT555656 PGRMC1 progesterone receptor membrane component 1 2 2
MIRT556286 MAP3K5 mitogen-activated protein kinase kinase kinase 5 2 2
MIRT557012 HOXD13 homeobox D13 2 4
MIRT563907 CLSPN claspin 2 2
MIRT565527 SON SON DNA binding protein 2 2
MIRT568000 COMMD2 COMM domain containing 2 2 2
MIRT569831 PLA2G16 phospholipase A2 group XVI 2 4
MIRT573905 PARP1 poly(ADP-ribose) polymerase 1 2 2
MIRT616589 KLHL9 kelch like family member 9 2 2
MIRT617137 ZNF556 zinc finger protein 556 2 2
MIRT617400 API5 apoptosis inhibitor 5 2 2
MIRT617455 CCS copper chaperone for superoxide dismutase 2 2
MIRT617799 ZNF793 zinc finger protein 793 2 2
MIRT618190 MACC1 MACC1, MET transcriptional regulator 2 2
MIRT618303 GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase 2 2
MIRT618329 ZNF813 zinc finger protein 813 2 2
MIRT618820 PHF20 PHD finger protein 20 2 2
MIRT619153 PPDPF pancreatic progenitor cell differentiation and proliferation factor 2 2
MIRT619530 ZNF708 zinc finger protein 708 2 2
MIRT619849 KIR3DX1 killer cell immunoglobulin like receptor, three Ig domains X1 2 2
MIRT620806 SLC26A2 solute carrier family 26 member 2 2 2
MIRT621312 YIPF4 Yip1 domain family member 4 2 2
MIRT621358 GUCA1B guanylate cyclase activator 1B 2 2
MIRT621366 ART4 ADP-ribosyltransferase 4 (Dombrock blood group) 2 2
MIRT621547 ZMYM1 zinc finger MYM-type containing 1 2 2
MIRT621883 TAOK1 TAO kinase 1 2 2
MIRT622451 RNF19B ring finger protein 19B 2 2
MIRT623404 KREMEN1 kringle containing transmembrane protein 1 2 2
MIRT623587 IPO9 importin 9 2 2
MIRT623974 FAM63A MINDY lysine 48 deubiquitinase 1 2 2
MIRT624086 DPP8 dipeptidyl peptidase 8 2 2
MIRT624108 DNAH10OS dynein axonemal heavy chain 10 opposite strand 2 2
MIRT632486 RNF8 ring finger protein 8 2 2
MIRT634057 PLIN3 perilipin 3 2 2
MIRT634657 GDE1 glycerophosphodiester phosphodiesterase 1 2 2
MIRT640682 MCUR1 mitochondrial calcium uniporter regulator 1 2 2
MIRT641242 CENPN centromere protein N 2 2
MIRT642260 ZNF677 zinc finger protein 677 2 2
MIRT642954 RELA RELA proto-oncogene, NF-kB subunit 2 2
MIRT644326 IPP intracisternal A particle-promoted polypeptide 2 2
MIRT644632 ICA1L islet cell autoantigen 1 like 2 2
MIRT645721 POLR3A RNA polymerase III subunit A 2 2
MIRT647850 LYPLA1 lysophospholipase I 2 2
MIRT649281 NEK8 NIMA related kinase 8 2 2
MIRT650038 VHL von Hippel-Lindau tumor suppressor 2 2
MIRT650354 RRP36 ribosomal RNA processing 36 2 2
MIRT651144 ZNF384 zinc finger protein 384 2 2
MIRT651778 UTP6 UTP6, small subunit processome component 2 2
MIRT652576 TLCD2 TLC domain containing 2 2 2
MIRT654621 PTPRJ protein tyrosine phosphatase, receptor type J 2 2
MIRT656023 MYO5A myosin VA 2 2
MIRT656105 MSRB3 methionine sulfoxide reductase B3 2 2
MIRT657749 GMEB1 glucocorticoid modulatory element binding protein 1 2 2
MIRT657924 GATSL2 cytosolic arginine sensor for mTORC1 subunit 2 2 2
MIRT658848 DUSP19 dual specificity phosphatase 19 2 2
MIRT659100 DENND6A DENN domain containing 6A 2 2
MIRT659153 DCX doublecortin 2 2
MIRT660870 ADRBK2 G protein-coupled receptor kinase 3 2 2
MIRT661941 FAHD1 fumarylacetoacetate hydrolase domain containing 1 2 2
MIRT663577 C10orf32 BLOC-1 related complex subunit 7 2 2
MIRT664625 WDPCP WD repeat containing planar cell polarity effector 2 4
MIRT666562 RHOBTB3 Rho related BTB domain containing 3 2 2
MIRT669992 GPR156 G protein-coupled receptor 156 2 4
MIRT670445 RSBN1L round spermatid basic protein 1 like 2 2
MIRT670853 IFNAR1 interferon alpha and beta receptor subunit 1 2 4
MIRT671942 SPPL3 signal peptide peptidase like 3 2 2
MIRT674269 LMOD3 leiomodin 3 2 2
MIRT674424 MIOX myo-inositol oxygenase 2 4
MIRT674982 ATP5G1 ATP synthase, H+ transporting, mitochondrial Fo complex subunit C1 (subunit 9) 2 2
MIRT675038 BACE2 beta-site APP-cleaving enzyme 2 2 4
MIRT675309 C2orf68 chromosome 2 open reading frame 68 2 2
MIRT675641 TTPAL alpha tocopherol transfer protein like 2 2
MIRT688688 CPS1 carbamoyl-phosphate synthase 1 2 2
MIRT689369 ZNF101 zinc finger protein 101 2 2
MIRT689605 AKAP6 A-kinase anchoring protein 6 2 2
MIRT691715 LARS leucyl-tRNA synthetase 2 2
MIRT695473 TRAT1 T-cell receptor associated transmembrane adaptor 1 2 2
MIRT695530 MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2 2 2
MIRT695878 CACNG8 calcium voltage-gated channel auxiliary subunit gamma 8 2 2
MIRT696586 ORMDL2 ORMDL sphingolipid biosynthesis regulator 2 2 2
MIRT703007 HEATR5A HEAT repeat containing 5A 2 2
MIRT707942 PHKA1 phosphorylase kinase regulatory subunit alpha 1 2 2
MIRT709765 GPR183 G protein-coupled receptor 183 2 2
MIRT710332 ZNF669 zinc finger protein 669 2 2
MIRT713249 ZFP30 ZFP30 zinc finger protein 2 2
MIRT716613 RBM18 RNA binding motif protein 18 2 2
MIRT733414 BAG2 BCL2 associated athanogene 2 2 0
MIRT756135 THSD7A thrombospondin type 1 domain containing 7A 3 1
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-1 Anthocyanin NULL 145858 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-1 Caffeic acid NULL 689043 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-1 Catechin approved 9064 Microarray apoE−/− mice 22253797 2012 up-regulated
miR-1 Curcumin NULL 969516 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-1 Ferulic acid NULL 445858 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-1 Hesperidin NULL 10621 Microarray apoE−/− mice 22253797 2012 up-regulated
miR-1 Quercetin NULL 5280343 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-1 Galactose NULL 6036 Quantitative real-time PCR lens 22736950 2012 up-regulated
miR-1 Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) NULL 8490 Microarray mouse brain 19270793 2009 down-regulated
miR-1 Trichostatin A (TSA) NULL 444732 Quantitative real-time PCR myocardial differentiation of mouse ES cells 19521018 2009 down-regulated
miR-1 Sulfonyl-hydrazone-1 (SHZ) NULL NULL Quantitative real-time PCR Murine broblast-derived Induced pluripotent stem cells 21445862 2011 up-regulated
miR-1 Cocaine NULL 446220 Next-generation sequencing ventral striatum 21708909 2011 up-regulated
miR-1 Atorvastatin approved 60823 Quantitative real-time PCR Cardiomyocyte 23860036 2013 down-regualted
miR-1 Glucose NULL 5793 Quantitative real-time PCR endothelial cells 24394957 2014 down-regulated
miR-1 Docosahexaenoic acid NULL 445580 Quantitative real-time PCR Caco-2 cells 24623846 2014 up-regulated
miR-1 Palmitic acid approved 985 Quantitative real-time PCR Caco-2 cells 24623846 2014 up-regulated
miR-1 17beta-estradiol (E2) approved 5757 Microarray MCF-7AKT breast cancer cells 19528081 2009 down-regulated
miR-1 Essential amino acids (EAA) NULL NULL Quantitative real-time PCR skeletal muscle of young adults 19828686 2009 up-regulated
miR-1 Hydrogen peroxide (H2O2) NULL 784 Quantitative real-time PCR Human umbilical vein endothelial cells 21527937 2011 down-regulated
miR-1 Trichostatin A (TSA) NULL 444732 Microarray apoptosis-resistant breast cancer cells 21971930 2011 up-regulated
miR-1 Arsenic trioxide approved 14888 Quantitative real-time PCR acute promyelocytic leukemia 22072212 2012 up-regulated
miR-1 5-Fluorouracil approved 3385 Microarray CNE cells 22614822 2012 up-regulated
miR-1 Bicalutamide approved 2375 Microarray prostate 22674191 2012 up-regulated
miR-1 Arsenic trioxide approved 14888 Quantitative real-time PCR cardia 22889704 2012 up-regulated
miR-1 Perfluorooctane sulfonate NULL 74483 Microarray zebrafish embryos 20878907 2011 up-regulated
miR-1 Quinidine approved 441074 Quantitative real-time PCR myocardial infarction (MI) rats 19775284 2009 up-regulated
miR-1 Tanshinone IIA NULL 164676 Quantitative real-time PCR myocardial infarction (MI) rats 19775284 2009 down-regulated
miR-1 Tanshinone IIA NULL 164676 Quantitative real-time PCR post-infarction rat cardiomyocytes 21220930 2011 down-regulated
miR-1 Isoproterenol approved 3779 Quantitative real-time PCR heart 22847192 2012 down-regulated
miR-1 Dexamethasone approved 5743 Microarray adrenals and granulosa cells 24205079 2014 up-regulated
miR-1 Thiourea (TU) NULL 737139 Quantitative real-time PCR skeletal muscle and heart 22142802 2012 up-regulated
miR-1 Thiourea (TU) NULL 737139 Quantitative real-time PCR skeletal muscle and heart 22142802 2012 down-regulated
miR-1 Isoproterenol approved 3779 Quantitative real-time PCR heart 22847192 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-1303 Oxaliplatin 6857599 NSC266046 approved sensitive High Colorectal Cancer cell line (RKO)
hsa-miR-1303 Oxaliplatin 6857599 NSC266046 approved resistant High Colorectal Cancer cell line (HT-29)
hsa-miR-1303 Imatinib 5291 NSC743414 approved sensitive High Gastrointestinal Stromal Tumor cell line (882R-NC, 882R-OE, 882R-KD)
hsa-miR-1303 Fulvestrant 17756771 NSC719276 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-1303 Rituximab sensitive High Diffuse Large B-Cell Lymphoma cell line (DB, NU-DHL-1, NU-DUL-1, MC-116, SU-DHL-4, SU-DHL-5, FARAGE, HBL-1, OCI-Ly3, OCI-Ly7, OCI-Ly8, OCI-Ly19, RIVA, SU-DHL-8, U2932)
hsa-miR-1303 Etoposide 36462 NSC141540 approved resistant High Colorectal Cancer cell line (HCT8)
hsa-miR-1303 Doxorubicin 31703 NSC123127 approved resistant High Colorectal Cancer cell line (HCT8)
hsa-miR-1303 Vinorelbine 44424639 approved resistant High Colorectal Cancer cell line (HCT8)
hsa-miR-1303 Vincristine 5978 approved resistant High Colorectal Cancer cell line (HCT8)
hsa-miR-1303 Paclitaxel 36314 NSC125973 approved resistant High Colorectal Cancer cell line (HCT8)
hsa-mir-1303 Dabrafenib 44462760 NSC764134 approved sensitive cell line (A375)
hsa-mir-1303 Cisplatin 5460033 NSC119875 approved resistant cell line (W1)
hsa-mir-1303 Topotecan 60699 NSC609699 approved resistant cell line (W1)
hsa-mir-1303 Androstenedione+Letrozole resistant cell line (MCF-7)
hsa-miR-1303 Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-1303 Osimertinib 71496458 NSC779217 approved sensitive cell line (HCC827)
hsa-miR-1303 Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-1303 Vemurafenib 42611257 NSC761431 approved resistant cell line (451Lu)
hsa-miR-1303 Palbociclib 5330286 NSC758247 approved resistant tissue (breast cancer)
hsa-miR-1303 Cisplatin 5460033 NSC119875 approved sensitive cell line
hsa-miR-1303 Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-1303 Paclitaxel 36314 NSC125973 approved resistant cell line (BAS)
hsa-miR-1303 Doxorubicin 31703 NSC123127 approved resistant cell line (HS578T)
hsa-miR-1303 Cisplatin 5460033 NSC119875 approved resistant cell line (CP20)
hsa-miR-1303 Cisplatin 5460033 NSC119875 approved sensitive cell line (MGC-803)
hsa-miR-1303 Oxaliplatin 6857599 NSC266046 approved sensitive cell line (IGROV-1)
hsa-miR-1303 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

Error report submission