miRTarBase - #MIRT518026


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pre-miRNA Information
pre-miRNA hsa-mir-4794   
Genomic Coordinates chr1: 64579847 - 64579923
Description Homo sapiens miR-4794 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4794
Sequence 9| UCUGGCUAUCUCACGAGACUGU |30
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1162954002 4 dbSNP
rs1349204197 5 dbSNP
rs1454714841 8 dbSNP
rs191156964 14 dbSNP
rs543526824 15 dbSNP
rs1284724491 19 dbSNP
rs945565778 19 dbSNP
Putative Targets

Gene Information
Gene Symbol ABHD15   
Synonyms -
Description abhydrolase domain containing 15
Transcript NM_198147   
Expression
Putative miRNA Targets on ABHD15
3'UTR of ABHD15
(miRNA target sites are highlighted)		 
>ABHD15|NM_198147|3'UTR
   1 AAGACCTGGCCTGAGAACCCCCAAGTCCTGCAAAGAAAAACAGAGCTGGGCAAGGGGGAGTCCTGGAAAGATGGGGCGGA
  81 CTGAACAGAGGGAGCTCCAGCTCTGTGCTCCTCATTCAGTCCCTCTCTCTTAAATTGGTGCCTTGAAAGAGAAGGAACGT
 161 CCTGCGAGCCTGCACTCACTTCATCCTCAGCAGAACTCCTGCCTGGCCTCTGCTCAACATATCCCTACTCATCCGGTCAG
 241 CAGCGGCGCGTTCCAGTCACTGTCACCTGTCACTGACATCACAAGCCAAAGGATAGCACTTTTTCAATCCATGGACTCAG
 321 GAGAAAATGCCCTCTTACTGGCAGTGGCTAGAGGGATGAGACGTTTGTGTATGTCACTGGGCAGTGACCCCGATTCTCAA
 401 GCTGGAGCCATTTGATGTCATGAGGACAGGATGTTTGTGTCTCGGCCCCACTTCCCTCATTTGCTCTGTGGTTGTGGCGC
 481 CCTGCTTTGACCGAATGCTCTGGCAACTGCGGCAGCAGGCTTGTGTGTGTGAGAAGGGCGGCAGAGGCAGTGGGGCTGGC
 561 TCGCTGAGGGCTGAGCAGGTAGAGAATGTGAATGTCCATCTCAAGGAATGCGAAGTTCCAATCTCTCAGAGGAGCTCTGC
 641 AAGTCTCAGCTAGGAATGGGGCTGATCTGGCCCCCAAGCCTCACTGGAGAGATCCCAAGGGTATTTTACAAATAGGAAGC
 721 GCTCTCATGCAGGATCTGAGGGCTTTGCTAGACCATGGTTCAAGGAGTCAGAATCTTGGCTACCCTACATGCTCCCTCTG
 801 GCACCATTTCAGGGGATTACTCCAGAGAGCTGCAGCCAGAACTGTTTATCTCCTGAGATATGGACTTTCTCTAAGTCAGG
 881 AAAAGCACAAACCTCATAACTTAGGTGTTTTCTGGTTGGTTGCTCCCTTTTCTGATCCTACTACTGGCCTCTCCCTTTCC
 961 AGAGCCAGGAGACACATCTGGGACCAGAGGAAACAAAAGCACCAAGAGGTTGACTAGAGCTGACCAGTGATTTACAAATA
1041 TTTCATATTCCAATGCTTCGTCTGCTCAATTATTCAAAAGGCCATCCCTGTAAAGGCAGAAAAGCTTCCTCTTAGATCTG
1121 GCCACTCAGCAAATAAGTGGGTATTTGGTTTTATGAAGAATAATGCTGAGGACTAGAGATATAGTATATCAGAGATAATA
1201 TATAGTATACAGGTTGATCTAAATATTCTGGTTTGGATTAGGCAATTAAAATTTTTTTGGCAACAGGACATATGTTTCCA
1281 TGTGTTGCTAAGATTCAAAAACTTTGCCCTGAAGTTTTATTTTAATCGTCATTGAGAAAGAGGGCTCCTGTTCTGACCTC
1361 AAAAACAGCAAAGCTGTTGTAAAGAAGAGAGCTGCTTATACGAAAACCCACATTCCAAGACTTGGTATAAGGTATTCCTG
1441 AGGCCTTGATTTCAGGTTTGGATAATCTTGCCCCAGATTCTAGATCTTGTTCTTCTAGATCAAATCAGAAGAAACTTTGA
1521 AATAACTCCAAGAATCTGCACTGAAATGTAGACAGCACTCGATAATCTAAGGGACATTATCTTGTTGTGAAAAATTATCT
1601 CCCTCCTGGCTGGGAGCGGTGGCACACACCTATAATCTCAGCACTTTGGGAGGCCGAGGTGGGTGGATCACGAGGTCAGG
1681 AGATCGAGACCATCCTGGCTAACACAGTGAAACCTCATCTCTACTAAAAATACAAAAAATTAGCCGGGCGTGGTAGCGGG
1761 TGCCTGTAATCCCAGTTACTCAGGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGGAGGCGGAGCTTGCAGTGAGCTGAG
1841 ATCGCACCACTGCACTCCAGCCTGGGCGACAGAGTAAGACTGTGTTTCAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' ugucagagcacucuAUCGGUCu 5'
                        |||||:| 
Target 5' aaaatacaaaaaatTAGCCGGg 3'
 1727 - 1748 124.00 -9.50
2 
miRNA  3' ugucaGAGCACUCU----AUCGGUCu 5'
               |||  ||||     |||||| 
Target 5' gattaCTCCAGAGAGCTGCAGCCAGa 3'
 815 - 840 123.00 -16.50
3 
miRNA  3' ugucagagcacucuaUCGGUCu 5'
                         |||||| 
Target 5' cctctccctttccagAGCCAGg 3'
 948 - 969 120.00 -12.09
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31553465 47 COSMIC
COSN30153527 83 COSMIC
COSN21665679 201 COSMIC
COSN22509291 502 COSMIC
COSN21136147 510 COSMIC
COSN8834228 688 COSMIC
COSN8241429 696 COSMIC
COSN26576133 788 COSMIC
COSN26508839 837 COSMIC
COSN31540796 882 COSMIC
COSN26263414 991 COSMIC
COSN31488032 1022 COSMIC
COSN1716150 1059 COSMIC
COSN5415248 1060 COSMIC
COSN22410441 1192 COSMIC
COSN16865725 1234 COSMIC
COSN22737545 1508 COSMIC
COSN25164858 1992 COSMIC
COSN25167694 1994 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs539307 1 dbSNP
rs542605305 3 dbSNP
rs777214610 5 dbSNP
rs1430410976 7 dbSNP
rs1344083781 10 dbSNP
rs770873228 12 dbSNP
rs1411921576 13 dbSNP
rs375930056 17 dbSNP
rs773280096 18 dbSNP
rs1408143977 19 dbSNP
rs1360944829 24 dbSNP
rs1177477553 29 dbSNP
rs1409440188 30 dbSNP
rs772479385 35 dbSNP
rs747952644 36 dbSNP
rs530464744 44 dbSNP
rs1320739974 46 dbSNP
rs768584286 47 dbSNP
rs1390276632 49 dbSNP
rs1393785827 51 dbSNP
rs1334127386 53 dbSNP
rs915424556 54 dbSNP
rs375448386 55 dbSNP
rs558735304 60 dbSNP
rs1286875554 71 dbSNP
rs1479239656 75 dbSNP
rs1328848978 77 dbSNP
rs150377769 78 dbSNP
rs932618614 79 dbSNP
rs921291013 82 dbSNP
rs1193708004 86 dbSNP
rs1445924523 87 dbSNP
rs1270250692 92 dbSNP
rs1199920799 94 dbSNP
rs1256895450 106 dbSNP
rs1442968155 107 dbSNP
rs1189896766 110 dbSNP
rs1249366197 113 dbSNP
rs1472134532 121 dbSNP
rs1159529491 125 dbSNP
rs1413669290 131 dbSNP
rs1464146291 137 dbSNP
rs184261567 139 dbSNP
rs1402238803 141 dbSNP
rs553114867 152 dbSNP
rs1398306903 153 dbSNP
rs1259507030 155 dbSNP
rs748350698 157 dbSNP
rs541259258 158 dbSNP
rs573969692 159 dbSNP
rs910182691 163 dbSNP
rs1345720218 165 dbSNP
rs191343692 166 dbSNP
rs1329588597 173 dbSNP
rs1232758391 197 dbSNP
rs1256668911 201 dbSNP
rs537760199 208 dbSNP
rs569906411 211 dbSNP
rs954440481 220 dbSNP
rs1272381743 224 dbSNP
rs776421724 234 dbSNP
rs983245157 235 dbSNP
rs950587192 236 dbSNP
rs1325915967 241 dbSNP
rs1197633953 244 dbSNP
rs539132947 245 dbSNP
rs140915849 247 dbSNP
rs112075008 248 dbSNP
rs546795176 249 dbSNP
rs368582873 250 dbSNP
rs895566743 274 dbSNP
rs572235494 275 dbSNP
rs1386437874 281 dbSNP
rs906564858 283 dbSNP
rs1031874088 284 dbSNP
rs1332974930 285 dbSNP
rs1042834857 288 dbSNP
rs1295376961 296 dbSNP
rs1425247912 297 dbSNP
rs757954589 309 dbSNP
rs1170967696 312 dbSNP
rs186921663 314 dbSNP
rs904713078 316 dbSNP
rs945497673 319 dbSNP
rs1370843078 320 dbSNP
rs1208943627 328 dbSNP
rs1267581563 337 dbSNP
rs1043303900 341 dbSNP
rs915370719 342 dbSNP
rs1053964264 346 dbSNP
rs1450645649 362 dbSNP
rs377376104 363 dbSNP
rs987763323 368 dbSNP
rs1294380242 374 dbSNP
rs1393117141 380 dbSNP
rs954512705 381 dbSNP
rs548965638 386 dbSNP
rs1320008362 389 dbSNP
rs1442879201 391 dbSNP
rs918949100 392 dbSNP
rs530835646 398 dbSNP
rs1297637431 403 dbSNP
rs1319751653 408 dbSNP
rs563108582 414 dbSNP
rs530344002 422 dbSNP
rs1041053125 426 dbSNP
rs770955054 429 dbSNP
rs11867220 432 dbSNP
rs1206367827 438 dbSNP
rs963107320 443 dbSNP
rs139619101 444 dbSNP
rs878868351 444 dbSNP
rs1170741969 445 dbSNP
rs1423643984 446 dbSNP
rs878994975 450 dbSNP
rs1012702977 453 dbSNP
rs1268470550 461 dbSNP
rs908615776 466 dbSNP
rs958558147 469 dbSNP
rs1247113040 471 dbSNP
rs1432942556 471 dbSNP
rs1290614063 474 dbSNP
rs532846597 478 dbSNP
rs559048065 479 dbSNP
rs145663736 488 dbSNP
rs1402895998 489 dbSNP
rs973260899 492 dbSNP
rs1042393199 493 dbSNP
rs1267099350 496 dbSNP
rs1009619096 498 dbSNP
rs1217282863 503 dbSNP
rs1235190194 505 dbSNP
rs970004409 506 dbSNP
rs371612364 511 dbSNP
rs567940881 519 dbSNP
rs1053911734 523 dbSNP
rs573857262 529 dbSNP
rs943498042 533 dbSNP
rs992501033 536 dbSNP
rs960005798 539 dbSNP
rs555933714 540 dbSNP
rs745423966 549 dbSNP
rs778593044 550 dbSNP
rs543732007 554 dbSNP
rs1357208234 560 dbSNP
rs910750769 562 dbSNP
rs551334573 563 dbSNP
rs530472768 567 dbSNP
rs1164446707 576 dbSNP
rs1311040814 578 dbSNP
rs1211506850 582 dbSNP
rs1444718272 584 dbSNP
rs968842698 596 dbSNP
rs1482309430 599 dbSNP
rs1021809103 611 dbSNP
rs756863268 612 dbSNP
rs1471284792 617 dbSNP
rs564909300 621 dbSNP
rs1424620532 623 dbSNP
rs900079295 628 dbSNP
rs1433840835 634 dbSNP
rs1441540431 638 dbSNP
rs1238529432 639 dbSNP
rs1377172768 660 dbSNP
rs1427684940 661 dbSNP
rs34394684 662 dbSNP
rs569624108 664 dbSNP
rs1307215516 672 dbSNP
rs1041727592 678 dbSNP
rs971748911 680 dbSNP
rs941742392 681 dbSNP
rs1195246575 682 dbSNP
rs576691209 694 dbSNP
rs908949480 700 dbSNP
rs1008215718 703 dbSNP
rs958504387 712 dbSNP
rs1035545416 720 dbSNP
rs887126010 721 dbSNP
rs1047107490 741 dbSNP
rs931406271 742 dbSNP
rs920390676 753 dbSNP
rs1219729771 755 dbSNP
rs1211646425 756 dbSNP
rs753443818 758 dbSNP
rs1037496698 761 dbSNP
rs1478424527 763 dbSNP
rs1195600993 779 dbSNP
rs1020652318 782 dbSNP
rs756429604 783 dbSNP
rs915819610 793 dbSNP
rs993179711 798 dbSNP
rs116832636 806 dbSNP
rs539870964 809 dbSNP
rs1420030547 813 dbSNP
rs1411442013 815 dbSNP
rs75833025 818 dbSNP
rs893834951 827 dbSNP
rs74484133 842 dbSNP
rs924284472 846 dbSNP
rs977134407 848 dbSNP
rs753402206 849 dbSNP
rs1379820666 852 dbSNP
rs1032413510 854 dbSNP
rs968457352 860 dbSNP
rs566175217 861 dbSNP
rs1021422801 863 dbSNP
rs1007660962 866 dbSNP
rs889245298 901 dbSNP
rs755363222 903 dbSNP
rs554348569 909 dbSNP
rs1469096331 914 dbSNP
rs1019846177 919 dbSNP
rs115565555 925 dbSNP
rs1464486034 927 dbSNP
rs753066668 928 dbSNP
rs1037046953 937 dbSNP
rs763473002 941 dbSNP
rs1242596914 944 dbSNP
rs567301581 946 dbSNP
rs549180509 947 dbSNP
rs1161174328 948 dbSNP
rs1461655747 954 dbSNP
rs991176962 955 dbSNP
rs1385891437 964 dbSNP
rs556867254 972 dbSNP
rs760433407 988 dbSNP
rs937093004 999 dbSNP
rs928422637 1000 dbSNP
rs981287983 1007 dbSNP
rs967653288 1008 dbSNP
rs1235428053 1010 dbSNP
rs1176372337 1013 dbSNP
rs765307222 1017 dbSNP
rs1328628340 1021 dbSNP
rs1020181474 1023 dbSNP
rs1263900156 1029 dbSNP
rs1448668523 1037 dbSNP
rs990095033 1044 dbSNP
rs995506922 1053 dbSNP
rs183331853 1060 dbSNP
rs1032347815 1069 dbSNP
rs1456336501 1071 dbSNP
rs1007615495 1072 dbSNP
rs889198752 1074 dbSNP
rs1045156745 1081 dbSNP
rs140593140 1082 dbSNP
rs1356575129 1093 dbSNP
rs1416973691 1095 dbSNP
rs532808526 1104 dbSNP
rs1286741066 1127 dbSNP
rs1350137469 1128 dbSNP
rs948564807 1130 dbSNP
rs997678620 1137 dbSNP
rs898019304 1142 dbSNP
rs1342949077 1143 dbSNP
rs1036546221 1145 dbSNP
rs1220422625 1161 dbSNP
rs942307359 1164 dbSNP
rs558935684 1165 dbSNP
rs1285578307 1175 dbSNP
rs544745314 1182 dbSNP
rs1249296592 1190 dbSNP
rs1418152507 1202 dbSNP
rs1348965761 1205 dbSNP
rs1057016569 1210 dbSNP
rs762039818 1213 dbSNP
rs1172542443 1223 dbSNP
rs1376567169 1245 dbSNP
rs938603917 1251 dbSNP
rs1437069406 1252 dbSNP
rs1370279096 1259 dbSNP
rs572637945 1259 dbSNP
rs529007690 1265 dbSNP
rs1344529363 1266 dbSNP
rs1300690110 1267 dbSNP
rs1055394284 1273 dbSNP
rs767965965 1274 dbSNP
rs35456552 1280 dbSNP
rs977080796 1285 dbSNP
rs947069073 1292 dbSNP
rs914310953 1302 dbSNP
rs1329459650 1305 dbSNP
rs975591783 1308 dbSNP
rs781622278 1327 dbSNP
rs1348543020 1328 dbSNP
rs1236315079 1334 dbSNP
rs937035001 1336 dbSNP
rs928400057 1340 dbSNP
rs1020210453 1342 dbSNP
rs1196083848 1343 dbSNP
rs1252185410 1348 dbSNP
rs987032704 1349 dbSNP
rs945887179 1350 dbSNP
rs913069143 1361 dbSNP
rs1455980719 1375 dbSNP
rs990042511 1393 dbSNP
rs367582873 1401 dbSNP
rs951630478 1402 dbSNP
rs1390023371 1406 dbSNP
rs1462788530 1408 dbSNP
rs911176523 1412 dbSNP
rs757106173 1415 dbSNP
rs1025888224 1428 dbSNP
rs995456070 1429 dbSNP
rs986128343 1437 dbSNP
rs1386388824 1439 dbSNP
rs1326666278 1443 dbSNP
rs953527246 1453 dbSNP
rs1030405564 1454 dbSNP
rs998024969 1455 dbSNP
rs562110096 1464 dbSNP
rs544029562 1467 dbSNP
rs1023698890 1472 dbSNP
rs1015050296 1476 dbSNP
rs1012756734 1485 dbSNP
rs1398941903 1486 dbSNP
rs1427009015 1487 dbSNP
rs1353855225 1489 dbSNP
rs1176945270 1492 dbSNP
rs576641539 1495 dbSNP
rs1469418443 1503 dbSNP
rs564846583 1512 dbSNP
rs567109666 1515 dbSNP
rs1429577623 1518 dbSNP
rs938569179 1524 dbSNP
rs1246582469 1525 dbSNP
rs903095641 1534 dbSNP
rs1041686182 1543 dbSNP
rs947018186 1552 dbSNP
rs1215697046 1553 dbSNP
rs1396866680 1555 dbSNP
rs1432950854 1560 dbSNP
rs1318510339 1561 dbSNP
rs1361207412 1571 dbSNP
rs1445814064 1572 dbSNP
rs1281141561 1577 dbSNP
rs1001188507 1581 dbSNP
rs774651438 1589 dbSNP
rs1322348999 1596 dbSNP
rs776777982 1608 dbSNP
rs1273396694 1609 dbSNP
rs1045456365 1615 dbSNP
rs945804172 1617 dbSNP
rs768497351 1618 dbSNP
rs1254583115 1621 dbSNP
rs1475082048 1633 dbSNP
rs760430497 1636 dbSNP
rs546210935 1642 dbSNP
rs912352381 1646 dbSNP
rs1158511132 1648 dbSNP
rs775550778 1655 dbSNP
rs1337098306 1661 dbSNP
rs1469102431 1664 dbSNP
rs935858800 1667 dbSNP
rs1353376546 1668 dbSNP
rs951576793 1672 dbSNP
rs1025832410 1675 dbSNP
rs974312783 1678 dbSNP
rs962654136 1685 dbSNP
rs1024067580 1686 dbSNP
rs1305692720 1688 dbSNP
rs1420276124 1690 dbSNP
rs1186053600 1700 dbSNP
rs1485150691 1712 dbSNP
rs572430168 1715 dbSNP
rs1485577670 1719 dbSNP
rs1212067065 1741 dbSNP
rs1245544678 1745 dbSNP
rs528213624 1746 dbSNP
rs896561730 1749 dbSNP
rs1035147016 1750 dbSNP
rs1002695434 1755 dbSNP
rs554211624 1757 dbSNP
rs903043345 1761 dbSNP
rs1313267121 1762 dbSNP
rs1376989527 1765 dbSNP
rs7218963 1769 dbSNP
rs1297245560 1773 dbSNP
rs962444298 1776 dbSNP
rs1014994615 1781 dbSNP
rs1006340046 1782 dbSNP
rs1347823416 1786 dbSNP
rs947294728 1794 dbSNP
rs1381166066 1804 dbSNP
rs1315657859 1805 dbSNP
rs1204144422 1812 dbSNP
rs1451893567 1813 dbSNP
rs892762817 1814 dbSNP
rs1403626495 1815 dbSNP
rs535923080 1820 dbSNP
rs574891271 1821 dbSNP
rs1453740511 1825 dbSNP
rs912283942 1829 dbSNP
rs745801414 1830 dbSNP
rs559212334 1833 dbSNP
rs1355358905 1835 dbSNP
rs1169777144 1837 dbSNP
rs1034551211 1843 dbSNP
rs1354772100 1844 dbSNP
rs555254126 1845 dbSNP
rs930119625 1846 dbSNP
rs918765841 1847 dbSNP
rs1369535222 1851 dbSNP
rs1444635351 1855 dbSNP
rs1306230713 1856 dbSNP
rs542399683 1861 dbSNP
rs1274109082 1862 dbSNP
rs573541132 1863 dbSNP
rs1219580323 1864 dbSNP
rs916879495 1865 dbSNP
rs991222056 1867 dbSNP
rs1468960459 1868 dbSNP
rs1194226128 1870 dbSNP
rs1009939670 1875 dbSNP
rs960769473 1877 dbSNP
rs1474355441 1888 dbSNP
rs78302945 1890 dbSNP
rs1035497299 1895 dbSNP
rs891549773 1896 dbSNP
rs1054230898 1901 dbSNP
rs1167140638 1901 dbSNP
rs548284467 1901 dbSNP
rs999629318 1901 dbSNP
rs935807865 1902 dbSNP
rs889638932 1909 dbSNP
rs1245114706 1911 dbSNP
rs1325232334 1915 dbSNP
rs1380554817 1930 dbSNP
rs1049644975 1933 dbSNP
rs1364510705 1937 dbSNP
rs1231763136 1945 dbSNP
rs933906813 1946 dbSNP
rs1335600747 1949 dbSNP
rs1215654793 1950 dbSNP
rs1282189587 1958 dbSNP
rs1311117807 1960 dbSNP
rs1192307610 1961 dbSNP
rs1242547420 1965 dbSNP
rs1476266967 1966 dbSNP
rs1185415868 1970 dbSNP
rs537276798 1977 dbSNP
rs1461602128 1987 dbSNP
rs1374240851 1989 dbSNP
rs569845757 1990 dbSNP
rs1400699809 1991 dbSNP
rs551299677 1994 dbSNP
rs967175029 1996 dbSNP
rs1319555608 2007 dbSNP
rs923264477 2009 dbSNP
rs1297834730 2015 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 116236.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM1065667. RNA binding protein: AGO1. Condition:4-thiouridine ...

- Memczak S; Jens M; Elefsinioti A; Torti F; et al., 2013, Nature.

Article - Memczak S; Jens M; Elefsinioti A; Torti F; et al.
- Nature, 2013
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.
LinkOut: [PMID: 23446348]
CLIP-seq Support 1 for dataset GSM1065667
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / 4-thiouridine, ML_MM_6
Location of target site ENST00000307201.4 | 3UTR | UCUCUACUAAAAACACAAAAUUAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
110 hsa-miR-4794 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT059821 EFNA1 ephrin A1 2 2
MIRT203153 BACH1 BTB domain and CNC homolog 1 2 2
MIRT334253 SERPINH1 serpin family H member 1 2 2
MIRT475239 IGF2BP3 insulin like growth factor 2 mRNA binding protein 3 2 2
MIRT482467 ADAR adenosine deaminase, RNA specific 2 4
MIRT482632 AAR2 AAR2 splicing factor homolog 2 2
MIRT511147 MRPL17 mitochondrial ribosomal protein L17 2 4
MIRT514416 RSL1D1 ribosomal L1 domain containing 1 2 2
MIRT514842 LYRM7 LYR motif containing 7 2 4
MIRT515343 CXorf36 chromosome X open reading frame 36 2 2
MIRT515806 ALOX5AP arachidonate 5-lipoxygenase activating protein 2 2
MIRT516396 NPR1 natriuretic peptide receptor 1 2 4
MIRT516622 DARS2 aspartyl-tRNA synthetase 2, mitochondrial 2 2
MIRT516959 SLC35F6 solute carrier family 35 member F6 2 2
MIRT517154 VHLL VHL like 2 2
MIRT517268 NRIP2 nuclear receptor interacting protein 2 2 2
MIRT517660 TRIM72 tripartite motif containing 72 2 4
MIRT518026 ABHD15 abhydrolase domain containing 15 2 2
MIRT518116 RNMTL1 mitochondrial rRNA methyltransferase 3 2 4
MIRT518143 C15orf40 chromosome 15 open reading frame 40 2 4
MIRT518232 C7orf55 formation of mitochondrial complex V assembly factor 1 homolog 2 2
MIRT518517 CASP10 caspase 10 2 2
MIRT518646 NOM1 nucleolar protein with MIF4G domain 1 2 2
MIRT519287 SPCS1 signal peptidase complex subunit 1 2 2
MIRT519487 PNPLA3 patatin like phospholipase domain containing 3 2 2
MIRT520917 ST13 ST13, Hsp70 interacting protein 2 2
MIRT520928 SSBP2 single stranded DNA binding protein 2 2 2
MIRT521966 PHAX phosphorylated adaptor for RNA export 2 4
MIRT522244 NPFFR1 neuropeptide FF receptor 1 2 2
MIRT523355 GTF3C6 general transcription factor IIIC subunit 6 2 2
MIRT525181 ZNF468 zinc finger protein 468 2 2
MIRT528221 METTL8 methyltransferase like 8 2 2
MIRT528437 COL9A2 collagen type IX alpha 2 chain 2 2
MIRT531504 NONO non-POU domain containing octamer binding 2 2
MIRT532597 SIX4 SIX homeobox 4 2 2
MIRT532761 LDHD lactate dehydrogenase D 2 2
MIRT536012 MECP2 methyl-CpG binding protein 2 2 2
MIRT536262 LPGAT1 lysophosphatidylglycerol acyltransferase 1 2 2
MIRT547555 LRRC58 leucine rich repeat containing 58 2 2
MIRT554691 RNF2 ring finger protein 2 2 2
MIRT557250 CRAMP1L cramped chromatin regulator homolog 1 2 2
MIRT563339 RPLP0 ribosomal protein lateral stalk subunit P0 2 2
MIRT573179 P2RX3 purinergic receptor P2X 3 2 2
MIRT574386 UBE2N ubiquitin conjugating enzyme E2 N 2 2
MIRT574638 LPCAT3 lysophosphatidylcholine acyltransferase 3 2 2
MIRT609143 ZNF610 zinc finger protein 610 2 4
MIRT609651 PACS2 phosphofurin acidic cluster sorting protein 2 2 2
MIRT610846 ZNF44 zinc finger protein 44 2 2
MIRT612345 TP53INP1 tumor protein p53 inducible nuclear protein 1 2 2
MIRT613002 GATA6 GATA binding protein 6 2 2
MIRT614095 PDE4C phosphodiesterase 4C 2 2
MIRT615512 AGTRAP angiotensin II receptor associated protein 2 2
MIRT621281 PIWIL1 piwi like RNA-mediated gene silencing 1 2 2
MIRT623367 LUC7L2 LUC7 like 2, pre-mRNA splicing factor 2 2
MIRT624508 C7orf55-LUC7L2 C7orf55-LUC7L2 readthrough 2 2
MIRT632570 POLQ DNA polymerase theta 2 2
MIRT634829 ARHGEF39 Rho guanine nucleotide exchange factor 39 2 2
MIRT639452 CTNNBL1 catenin beta like 1 2 2
MIRT642097 FBXL2 F-box and leucine rich repeat protein 2 2 2
MIRT648408 TRMT10B tRNA methyltransferase 10B 2 2
MIRT653936 SERPINC1 serpin family C member 1 2 2
MIRT658226 FBXL16 F-box and leucine rich repeat protein 16 2 2
MIRT662599 MAGEB4 MAGE family member B4 2 2
MIRT663190 IBA57 IBA57 homolog, iron-sulfur cluster assembly 2 2
MIRT664623 DNPEP aspartyl aminopeptidase 2 2
MIRT671879 ZNF429 zinc finger protein 429 2 2
MIRT679033 ZNF419 zinc finger protein 419 2 2
MIRT684892 ZSCAN22 zinc finger and SCAN domain containing 22 2 2
MIRT685153 DTWD2 DTW domain containing 2 2 2
MIRT686415 TVP23C trans-golgi network vesicle protein 23 homolog C 2 2
MIRT687021 RNF24 ring finger protein 24 2 2
MIRT688369 ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 2 2
MIRT689600 FAM96A family with sequence similarity 96 member A 2 2
MIRT690375 ZSWIM7 zinc finger SWIM-type containing 7 2 2
MIRT690484 RSRC1 arginine and serine rich coiled-coil 1 2 2
MIRT691458 C21orf58 chromosome 21 open reading frame 58 2 2
MIRT691861 ZNF552 zinc finger protein 552 2 2
MIRT692035 ARSK arylsulfatase family member K 2 2
MIRT693951 HNRNPA1L2 heterogeneous nuclear ribonucleoprotein A1-like 2 2 2
MIRT694058 NQO2 N-ribosyldihydronicotinamide:quinone reductase 2 2 2
MIRT694469 LRTOMT leucine rich transmembrane and O-methyltransferase domain containing 2 2
MIRT695028 ALG10B ALG10B, alpha-1,2-glucosyltransferase 2 2
MIRT695093 CHRNB1 cholinergic receptor nicotinic beta 1 subunit 2 2
MIRT696624 WDR77 WD repeat domain 77 2 2
MIRT697446 ZCCHC8 zinc finger CCHC-type containing 8 2 2
MIRT697871 UBE2D3 ubiquitin conjugating enzyme E2 D3 2 2
MIRT700637 PQLC2 PQ loop repeat containing 2 2 2
MIRT701192 OTUD3 OTU deubiquitinase 3 2 2
MIRT701332 NSD1 nuclear receptor binding SET domain protein 1 2 2
MIRT702199 LPP LIM domain containing preferred translocation partner in lipoma 2 2
MIRT702891 HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 2 2
MIRT704389 CTSS cathepsin S 2 2
MIRT704922 CCDC36 coiled-coil domain containing 36 2 2
MIRT705770 ALG14 ALG14, UDP-N-acetylglucosaminyltransferase subunit 2 2
MIRT705797 ALDH6A1 aldehyde dehydrogenase 6 family member A1 2 2
MIRT705874 AEN apoptosis enhancing nuclease 2 2
MIRT707372 ORAI2 ORAI calcium release-activated calcium modulator 2 2 2
MIRT707426 RRP7A ribosomal RNA processing 7 homolog A 2 2
MIRT710293 SPN sialophorin 2 2
MIRT710744 ZNF71 zinc finger protein 71 2 2
MIRT713183 ERO1L endoplasmic reticulum oxidoreductase 1 alpha 1 1
MIRT715030 RANBP6 RAN binding protein 6 2 2
MIRT715829 ZNF598 zinc finger protein 598 2 2
MIRT720340 BACE2 beta-site APP-cleaving enzyme 2 2 2
MIRT722662 VKORC1L1 vitamin K epoxide reductase complex subunit 1 like 1 2 2
MIRT722683 RRM2 ribonucleotide reductase regulatory subunit M2 2 2
MIRT723908 PEX11A peroxisomal biogenesis factor 11 alpha 2 2
MIRT724044 SMIM14 small integral membrane protein 14 2 2
MIRT725241 PDE1B phosphodiesterase 1B 2 2
MIRT725307 NLRC5 NLR family CARD domain containing 5 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4794 Doxorubicin 31703 NSC123127 approved resistant High Triple-Negative Breast Cancer cell line (MDA-MB-231, MDA-MB-468)
hsa-miR-4794 Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)
hsa-miR-4794 Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (100 ng/ml)
hsa-miR-4794 Gemcitabine 60750 NSC613327 approved sensitive cell line (Panc1-GR4)

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