pre-miRNA Information
pre-miRNA hsa-mir-6737   
Genomic Coordinates chr1: 153962351 - 153962420
Description Homo sapiens miR-6737 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6737-5p
Sequence 6| UUGGGGUGGUCGGCCCUGGAG |26
Evidence Experimental
Experiments Meta-analysis
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs766338599 4 dbSNP
rs765728788 7 dbSNP
rs757341439 9 dbSNP
rs539511149 11 dbSNP
rs764259486 12 dbSNP
rs988937601 21 dbSNP
Putative Targets

Gene Information
Gene Symbol LEAP2   
Synonyms LEAP-2
Description liver enriched antimicrobial peptide 2
Transcript NM_052971   
Expression
Putative miRNA Targets on LEAP2
3'UTR of LEAP2
(miRNA target sites are highlighted)
>LEAP2|NM_052971|3'UTR
   1 TGTACATACCAGGGAAAGAAAGGACAGCAGTCACCTCCGACAATGCTCCGTTCTATGGAATATTGATTAACTGCATTTTG
  81 GCTGGAGACACCCAAGTGAAGCAATCTTGTATTTTTAATATTTAAAGGCAGATGTACGCTTTAAATTGGTCTCCATTTCT
 161 TCTTAGAATGTTGATATATGGATAAGCATAACTAAACTTGTCAATTTAGAGTTTATTTTTCTATGGATACTATTAAATGT
 241 CTCAAATTGAAATTTTAGCAGTCTGGAATTCAAGCTTTTGAGGGAAAGAAGGATTCATTTTGTATACTAAAGAAAAAAAC
 321 AGCATTGCCCAATAATGTGTTAACTTCTCAATCTGGAAAGTGTAGTGAGAGCTACATAATCAATAGCTACGTAATCAACT
 401 TCAGCAAGTTCCTAAGCTGTGGCCCTGGATCCCTTCACTCCATA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' gaGGUCCCGGCUGGUGGGGUu 5'
            |::|  ||  :|||:||| 
Target 5' ccCTGGATCCCTTCACTCCAt 3'
423 - 443 135.00 -18.00
2
miRNA  3' gaggucCCGGC--UGGUGGGGUu 5'
                |||:|  : ||||| | 
Target 5' cattttGGCTGGAGACACCCAAg 3'
74 - 96 117.00 -18.40
3
miRNA  3' gaggUCCCG--GCUGGUGGGGuu 5'
              ||| |  | ::||||:|  
Target 5' agaaAGGACAGCAGTCACCTCcg 3'
17 - 39 115.00 -13.70
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN2070623 7 COSMIC
COSN30458984 13 COSMIC
COSN30135267 19 COSMIC
COSN30518003 38 COSMIC
COSN26982321 40 COSMIC
COSN30501329 41 COSMIC
COSN26566714 66 COSMIC
COSN24310296 81 COSMIC
COSN26556798 94 COSMIC
COSN22871344 122 COSMIC
COSN30115482 148 COSMIC
COSN31525768 167 COSMIC
COSN20947247 260 COSMIC
COSN17181925 272 COSMIC
COSN6863534 506 COSMIC
COSN20443811 537 COSMIC
rs57880964 537 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1026541933 5 dbSNP
rs1003927671 6 dbSNP
rs1310253885 14 dbSNP
rs1217729707 15 dbSNP
rs536726305 16 dbSNP
rs374440479 19 dbSNP
rs752738018 19 dbSNP
rs550686037 20 dbSNP
rs757962696 22 dbSNP
rs553886222 23 dbSNP
rs1435092126 26 dbSNP
rs1003464106 27 dbSNP
rs1035048835 28 dbSNP
rs1190625079 29 dbSNP
rs1292684253 30 dbSNP
rs1063473 36 dbSNP
rs777191065 39 dbSNP
rs567118058 40 dbSNP
rs78152968 43 dbSNP
rs780394898 44 dbSNP
rs1431778547 46 dbSNP
rs368359861 48 dbSNP
rs371833666 50 dbSNP
rs758061364 50 dbSNP
rs374069581 51 dbSNP
rs1419635557 54 dbSNP
rs968166537 55 dbSNP
rs779085742 56 dbSNP
rs1405135835 61 dbSNP
rs748407670 64 dbSNP
rs772149297 65 dbSNP
rs1225253736 75 dbSNP
rs1385937073 81 dbSNP
rs959389314 88 dbSNP
rs1307444469 91 dbSNP
rs773189384 103 dbSNP
rs1237897982 107 dbSNP
rs777557978 118 dbSNP
rs148298852 125 dbSNP
rs1388421202 128 dbSNP
rs1173964635 134 dbSNP
rs535381095 138 dbSNP
rs75906358 139 dbSNP
rs966547473 140 dbSNP
rs578142680 144 dbSNP
rs978334108 149 dbSNP
rs1320226101 150 dbSNP
rs942437368 150 dbSNP
rs1191622717 151 dbSNP
rs1488226027 156 dbSNP
rs543535129 180 dbSNP
rs780673814 184 dbSNP
rs922512839 187 dbSNP
rs919679681 190 dbSNP
rs929777711 192 dbSNP
rs563818763 206 dbSNP
rs910870017 212 dbSNP
rs1193424876 213 dbSNP
rs1397597748 215 dbSNP
rs907108032 216 dbSNP
rs938637795 222 dbSNP
rs1268589724 227 dbSNP
rs1313398814 233 dbSNP
rs941032797 237 dbSNP
rs1038092982 248 dbSNP
rs1190815282 257 dbSNP
rs1462643312 262 dbSNP
rs1426085264 264 dbSNP
rs1168541073 265 dbSNP
rs1425189912 281 dbSNP
rs1418752270 284 dbSNP
rs1190183915 286 dbSNP
rs749837413 290 dbSNP
rs929450855 295 dbSNP
rs1196779433 298 dbSNP
rs803221 299 dbSNP
rs1259612669 304 dbSNP
rs1347886886 305 dbSNP
rs1216480313 306 dbSNP
rs1459307781 310 dbSNP
rs1316741168 311 dbSNP
rs1288235648 313 dbSNP
rs368037675 318 dbSNP
rs1339685647 321 dbSNP
rs906736544 322 dbSNP
rs559364254 326 dbSNP
rs1338647230 336 dbSNP
rs1012663433 337 dbSNP
rs1391764118 338 dbSNP
rs1022353036 356 dbSNP
rs1465338365 360 dbSNP
rs1055332313 361 dbSNP
rs1165097871 370 dbSNP
rs3822760 373 dbSNP
rs1368408280 376 dbSNP
rs1010881788 379 dbSNP
rs1441920363 380 dbSNP
rs1022340971 391 dbSNP
rs545315989 392 dbSNP
rs1289906605 395 dbSNP
rs1211142822 406 dbSNP
rs999670222 412 dbSNP
rs1354084793 416 dbSNP
rs1051783791 417 dbSNP
rs1240858353 439 dbSNP
rs1378797312 441 dbSNP
rs999651792 457 dbSNP
rs1446261875 459 dbSNP
rs1029909277 462 dbSNP
rs1325536016 467 dbSNP
rs1403692411 470 dbSNP
rs1390186530 472 dbSNP
rs1159652203 491 dbSNP
rs756213302 491 dbSNP
rs1422100897 496 dbSNP
rs1378826040 498 dbSNP
rs1031198600 502 dbSNP
rs1178432306 508 dbSNP
rs1438647962 509 dbSNP
rs564916527 513 dbSNP
rs955799841 521 dbSNP
rs1246929892 523 dbSNP
rs1200299470 528 dbSNP
rs1449364412 529 dbSNP
rs1224164437 530 dbSNP
rs1288609288 531 dbSNP
rs1008513396 534 dbSNP
rs1018356417 535 dbSNP
rs57880964 537 dbSNP
rs1355796386 539 dbSNP
rs1488226830 550 dbSNP
rs973717829 556 dbSNP
rs1192177061 558 dbSNP
rs1368508544 563 dbSNP
rs1264678412 565 dbSNP
rs1477894631 566 dbSNP
rs919649518 569 dbSNP
rs1411091553 576 dbSNP
rs1425196348 580 dbSNP
rs550377461 582 dbSNP
rs1351117942 583 dbSNP
rs1435741174 583 dbSNP
rs1440947463 584 dbSNP
rs1217662847 585 dbSNP
rs1278876070 585 dbSNP
rs1330612881 585 dbSNP
rs1339014793 585 dbSNP
rs1344604189 585 dbSNP
rs1401924689 585 dbSNP
rs35973948 585 dbSNP
rs373393327 585 dbSNP
rs1449488710 586 dbSNP
rs72165296 586 dbSNP
rs1300027135 589 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 116842.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM1065667. RNA binding protein: AGO1. Condition:4-thiouridine ...

- Memczak S; Jens M; Elefsinioti A; Torti F; et al., 2013, Nature.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' gagguccCGGCUG--GUGGGGUu 5'
                 ||| ||  ||||||| 
Target 5' --aucauGCC-ACUGCACCCCAg 3'
1 - 20
Article - Memczak S; Jens M; Elefsinioti A; Torti F; et al.
- Nature, 2013
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.
LinkOut: [PMID: 23446348]
CLIP-seq Support 1 for dataset GSM1065667
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / 4-thiouridine, ML_MM_6
Location of target site ENST00000296877.2 | 3UTR | AUCAUGCCACUGCACCCCAGCCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
67 hsa-miR-6737-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT066215 MARCH9 membrane associated ring-CH-type finger 9 2 2
MIRT074413 TNRC6A trinucleotide repeat containing 6A 2 2
MIRT125300 MID1IP1 MID1 interacting protein 1 2 2
MIRT153951 NCOA3 nuclear receptor coactivator 3 2 2
MIRT452776 FAM136A family with sequence similarity 136 member A 2 2
MIRT452977 CABP4 calcium binding protein 4 2 2
MIRT454128 FOXRED2 FAD dependent oxidoreductase domain containing 2 2 2
MIRT455242 DDX39B DExD-box helicase 39B 2 10
MIRT459007 UQCRH ubiquinol-cytochrome c reductase hinge protein 2 2
MIRT459463 MUC17 mucin 17, cell surface associated 2 4
MIRT460871 UBE2S ubiquitin conjugating enzyme E2 S 2 2
MIRT461264 COX10 COX10, heme A:farnesyltransferase cytochrome c oxidase assembly factor 2 2
MIRT464540 UBTF upstream binding transcription factor, RNA polymerase I 2 2
MIRT465268 TRIM28 tripartite motif containing 28 2 2
MIRT465871 TMEM43 transmembrane protein 43 2 4
MIRT466228 TMED10 transmembrane p24 trafficking protein 10 2 2
MIRT468417 SETD1B SET domain containing 1B 2 2
MIRT468684 SEC22C SEC22 homolog C, vesicle trafficking protein 2 4
MIRT473399 MDM4 MDM4, p53 regulator 2 2
MIRT473517 MAX MYC associated factor X 2 2
MIRT474511 KLHDC8A kelch domain containing 8A 2 2
MIRT475801 HDGF heparin binding growth factor 2 2
MIRT479493 CDH6 cadherin 6 2 2
MIRT480770 BMP2 bone morphogenetic protein 2 2 2
MIRT481418 ASB6 ankyrin repeat and SOCS box containing 6 2 2
MIRT482966 CSTF2 cleavage stimulation factor subunit 2 2 2
MIRT483380 SPATA6 spermatogenesis associated 6 2 4
MIRT483677 CYP11A1 cytochrome P450 family 11 subfamily A member 1 2 2
MIRT484328 EPN1 epsin 1 2 4
MIRT484963 UCK1 uridine-cytidine kinase 1 2 2
MIRT485908 PGPEP1 pyroglutamyl-peptidase I 2 4
MIRT488149 PRRC2B proline rich coiled-coil 2B 2 4
MIRT488943 CYP2W1 cytochrome P450 family 2 subfamily W member 1 2 6
MIRT491835 ZBTB7A zinc finger and BTB domain containing 7A 2 4
MIRT493026 NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit 2 2
MIRT499374 PLCG2 phospholipase C gamma 2 2 11
MIRT499723 USH1G USH1 protein network component sans 2 4
MIRT500349 ZNF385A zinc finger protein 385A 2 2
MIRT509574 HIST2H2AB histone cluster 2 H2A family member b 2 4
MIRT512794 GLRX glutaredoxin 2 2
MIRT513291 SETBP1 SET binding protein 1 2 2
MIRT515697 ZNF321P zinc finger protein 321, pseudogene 2 2
MIRT518255 LEAP2 liver enriched antimicrobial peptide 2 2 2
MIRT522026 PAQR3 progestin and adipoQ receptor family member 3 2 4
MIRT523169 HIST3H3 histone cluster 3 H3 2 2
MIRT524036 DNAJC8 DnaJ heat shock protein family (Hsp40) member C8 2 2
MIRT533476 TRIM71 tripartite motif containing 71 2 2
MIRT541488 ADM adrenomedullin 2 2
MIRT553987 SRPR SRP receptor alpha subunit 2 2
MIRT571445 YKT6 YKT6 v-SNARE homolog 2 2
MIRT574889 Plcg2 phospholipase C, gamma 2 2 7
MIRT607544 GLI2 GLI family zinc finger 2 2 2
MIRT607688 MAPK10 mitogen-activated protein kinase 10 2 2
MIRT610072 CRLF1 cytokine receptor like factor 1 2 2
MIRT610573 CACUL1 CDK2 associated cullin domain 1 2 2
MIRT614041 THBS2 thrombospondin 2 2 2
MIRT626318 LRTOMT leucine rich transmembrane and O-methyltransferase domain containing 2 2
MIRT634005 RIF1 replication timing regulatory factor 1 2 2
MIRT639619 FGF19 fibroblast growth factor 19 2 2
MIRT647343 RPH3AL rabphilin 3A like (without C2 domains) 2 2
MIRT689704 ATXN2 ataxin 2 2 2
MIRT691170 APOL6 apolipoprotein L6 2 2
MIRT693165 NPR1 natriuretic peptide receptor 1 2 2
MIRT711727 NUPL2 nucleoporin like 2 2 2
MIRT711806 ELN elastin 2 2
MIRT721546 FXN frataxin 2 2
MIRT722979 GDE1 glycerophosphodiester phosphodiesterase 1 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-6737 Ceritinib 57379345 NSC776422 approved sensitive High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-6737 Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)
hsa-miR-6737-5p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-6737-5p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-6737-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-6737-5p Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-6737-5p Paclitaxel 36314 NSC125973 approved resistant cell line (A2780)
hsa-miR-6737-5p Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)
hsa-miR-6737-5p Docetaxel+Cisplatin+5-Fluorouracil resistant tissue (hypopharyngeal squamous cell carcinoma)

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