pre-miRNA Information | |
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pre-miRNA | hsa-mir-5590 |
Genomic Coordinates | chr2: 134857820 - 134857873 |
Description | Homo sapiens miR-5590 stem-loop |
Comment | None |
RNA Secondary Structure |
Mature miRNA Information | ||||||||||||||||||||||||||||
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Mature miRNA | hsa-miR-5590-5p | |||||||||||||||||||||||||||
Sequence | 1| UUGCCAUACAUAGACUUUAUU |21 | |||||||||||||||||||||||||||
Evidence | Not_experimental | |||||||||||||||||||||||||||
Experiments | ||||||||||||||||||||||||||||
SNPs in miRNA |
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Putative Targets |
Gene Information | |||||||||||||||||||||
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Gene Symbol | GDPD1 | ||||||||||||||||||||
Synonyms | GDE4 | ||||||||||||||||||||
Description | glycerophosphodiester phosphodiesterase domain containing 1 | ||||||||||||||||||||
Transcript | NM_182569 | ||||||||||||||||||||
Other Transcripts | NM_001165994 , NM_001165993 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on GDPD1 | |||||||||||||||||||||
3'UTR of GDPD1 (miRNA target sites are highlighted) |
>GDPD1|NM_182569|3'UTR 1 AAAAAGAGGTACTTAGAAGTATTGAAGGAAAAAATGAAGACCTAAGAAAAAAATATTTCATGATCATTTCCCTAAGCCAT 81 TTCCAGAATGGTAAAAGGTTTAATCAGTTTTTATTACCTCATTTTTAAGCCTGTATGAGAATGTAGAAACTATATATTAT 161 ATGTATATTTATTTTAAATAATATTGTATATTTTATGTTTGTAAATTGTTTAGAAAGATAATTGGTTATGAGATGTAAGT 241 TTTAATTTCTTAATGTGCATTTTTGTTTCTAGATCTTATACAGAAATCTTGATTAATAACATACACAGAAATGTACATAC 321 TACATCATCTACAGAAATCTTGATCAATAACCTAGAAACTAGGTTATCTAGGTTATTGATCAAGATTTCTGTAGATGATG 401 CAGTGTTCTATCATAAGTAATTCTGGAATCAAAGACTATTGGATACATTTGGCATTGGGCTGAGTGTGGTGGCTCATGCC 481 TGTAATCCCAGCACTTTGGGAGGCTGAGACAGGCGGATCATCTGAAGTCAGGAGTTAAAGACCAGCCTGGCCAACATGGC 561 AAAACCCCATCTCTACCAAAAATACAAAAATTAACCATGCGTGGTGGTACACGTCTGTCATCCCAGCAGCTCTTAAGGCT 641 GAGGCACAAGAATTGCTTGAACCCGGGAGGCAGAGGCTGTAGTGAGCCAAGATAGCACCACTGCACTCCAGCCTGGGAGA 721 CAGAGTGAGACTCCGTCTCAAAAAAAAAAAAAAAAAAAAAAAATGGGAGGCCGAGGCGGGCGGATCACGAGGTCAGGAGA 801 TCGAGACCATCCTGGCTAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAAATTAGCTGGGCGTGGTGGTGGGCAC 881 CTTAGTCCCAGCTACTCGGGAGGCTGAGTCAGGAGAATGGCGTGAACCCGGGAGGCGGAGCTTGCAGTGAGCCGAGATCG 961 CGCCACTGCACTCCAGCCTGGGCTACAGAGCAAGACTCCGTCTCAAAAAAAGAAAAAAAGAAAAAAAATTGGCAATAGTC 1041 TTCACTGGAATACAATCAATTAGTAAAAGATTTTTTTTTTTTTTTTGACATGTAGTCTTGCTCTGTCGCCGAGGCCGGAG 1121 TGCAGTGGTGCGATCTTGGCTCACTGCAACCTCTGCCTCCCAGGTTCCAGCAATTCTCCTGCCTCTGCCTCCCGAGTACC 1201 TGGGATTACAGGTGCCTGCTACCATGCCCAGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTTGCCACGTTGGCCAGA 1281 CTGGTCTCGAACTCCTGACCTCAGGTGATCCACCCACCTCGGCCTCTCAAAGTGCTGGGATTACAGGTTTGAACCACTGC 1361 ACCCGGCCAGTAAAAGAAATTTTGAAGGCCATTGCAGCTATTTGGTAGTGTCTTGTTATTTCTAGGTGTACCTTAGTTAA 1441 AGAGGAAAAATAAAACGGAAAAAAGCTTGGAAATCAGTGATGTGTAGTTATTTGGCAAGTTATACATAATCAGCAGCAGC 1521 CAGGCTCAAGAAAATAAAAGTTGATTAGTTGATCAGAAATAAAATCTGTAGAGTGAATTAGATTTCTGAGTTGTTGTTGT 1601 TAATGGAACATTCTATTTGAGACCTTTTTCAGGTGTGTAGCAATTCTACCATGTCCATTTTTTTAAGCATTAAAAAGGAA 1681 CTTACCAGTTGTAAATTAAGACAAGATCCAAATAGTCATATTTTTGTGTTTCCTCTAAAAAAATGTAAGATTTCCATTTT 1761 TGGCACTGACTAACTGAGCCTACATCTAGATTTTAAATACCATCTTGAATCCTAATAATTAAACTGATGAAAGTGCATAT 1841 CATTGTTCCTAACATTTATGAACCCCCATAAAGATGTTCCTGATCTTTAAAACTCATTAATCTGAGTATTAAGTAGAAAC 1921 AGAATTTTCCAAAGCATTAGACATCACTTTCTCAGTTTATCTGAGGTGACTTCGTGTACATCTGTTTCTAATATATTTGA 2001 CTAATTTTCATGATCTCAGATTGTGAGGTAAATGTAATCTGGAATAATAAGTGTCTTTTACCTAGATTACATCTCTCATT 2081 TGGAGTTTGGCAATGAAACTGCTATGAAGAATGACTGTACTCTCCTATCTGTCCCTGGATGACATAAATATCATTTGCTT 2161 TGTTGTTTAAACTGAAATAAAGTTTTCCAAGAACAAAAAAAAAAAAAA Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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DRVs in gene 3'UTRs | |||||||||||||||||||||
SNPs in gene 3'UTRs |
Experimental Support 1 for Functional miRNA-Target Interaction | |
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miRNA:Target | ---- |
Validation Method |
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Conditions | HEK293 |
Disease | 284161.0 |
Location of target site | 3'UTR |
Tools used in this research | TargetScan , miRTarCLIP , Piranha |
Original Description (Extracted from the article) |
...
"PAR-CLIP data was present in GSM1065667. RNA binding protein: AGO1. Condition:4-thiouridine
... - Memczak S; Jens M; Elefsinioti A; Torti F; et al., 2013, Nature. |
Article |
- Memczak S; Jens M; Elefsinioti A; Torti F; et al. - Nature, 2013
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.
LinkOut: [PMID: 23446348]
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CLIP-seq Support 1 for dataset GSM1065667 | |
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Method / RBP | PAR-CLIP / AGO1 |
Cell line / Condition | HEK293 / 4-thiouridine, ML_MM_6 |
Location of target site | ENST00000284116.4 | 3UTR | CAAAACCCCAUCUCUACCAAAAAUAC |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23446348 / GSE43573 |
CLIP-seq Viewer | Link |
MiRNA-Target Expression Profile | |||||||
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MiRNA-Target Expression Profile (TCGA) | |||||||
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69 hsa-miR-5590-5p Target Genes:
Functional analysis:
ID | Target | Description | Validation methods | |||||||||
Strong evidence | Less strong evidence | |||||||||||
MIRT056313 | WAC | WW domain containing adaptor with coiled-coil | 2 | 6 | ||||||||
MIRT066181 | PIP4K2C | phosphatidylinositol-5-phosphate 4-kinase type 2 gamma | 2 | 2 | ||||||||
MIRT095612 | NR3C1 | nuclear receptor subfamily 3 group C member 1 | 2 | 2 | ||||||||
MIRT099166 | MYLIP | myosin regulatory light chain interacting protein | 2 | 2 | ||||||||
MIRT107578 | VLDLR | very low density lipoprotein receptor | 2 | 2 | ||||||||
MIRT179602 | CAPZA1 | capping actin protein of muscle Z-line alpha subunit 1 | 2 | 8 | ||||||||
MIRT241303 | ZC3H12C | zinc finger CCCH-type containing 12C | 2 | 8 | ||||||||
MIRT244620 | MCM4 | minichromosome maintenance complex component 4 | 2 | 2 | ||||||||
MIRT270705 | SBNO1 | strawberry notch homolog 1 | 2 | 4 | ||||||||
MIRT453616 | SNRPE | small nuclear ribonucleoprotein polypeptide E | 2 | 4 | ||||||||
MIRT453653 | RAB6C | RAB6C, member RAS oncogene family | 2 | 2 | ||||||||
MIRT464159 | VMP1 | vacuole membrane protein 1 | 2 | 15 | ||||||||
MIRT477720 | EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 2 | 2 | ||||||||
MIRT484301 | ENDOD1 | endonuclease domain containing 1 | 2 | 4 | ||||||||
MIRT496069 | GLCCI1 | glucocorticoid induced 1 | 2 | 2 | ||||||||
MIRT496338 | TMEM81 | transmembrane protein 81 | 2 | 2 | ||||||||
MIRT496653 | PITPNM3 | PITPNM family member 3 | 2 | 2 | ||||||||
MIRT499098 | DENND4C | DENN domain containing 4C | 2 | 8 | ||||||||
MIRT499862 | SVOP | SV2 related protein | 2 | 12 | ||||||||
MIRT504913 | CD38 | CD38 molecule | 2 | 4 | ||||||||
MIRT515401 | WDR72 | WD repeat domain 72 | 2 | 4 | ||||||||
MIRT518156 | TMEM133 | transmembrane protein 133 | 2 | 2 | ||||||||
MIRT518558 | GDPD1 | glycerophosphodiester phosphodiesterase domain containing 1 | 2 | 2 | ||||||||
MIRT518636 | NOM1 | nucleolar protein with MIF4G domain 1 | 2 | 2 | ||||||||
MIRT518724 | ABCG8 | ATP binding cassette subfamily G member 8 | 2 | 2 | ||||||||
MIRT524301 | CTC1 | CST telomere replication complex component 1 | 2 | 4 | ||||||||
MIRT524472 | CHRM3 | cholinergic receptor muscarinic 3 | 2 | 4 | ||||||||
MIRT527562 | ADCY7 | adenylate cyclase 7 | 2 | 2 | ||||||||
MIRT532694 | TCN2 | transcobalamin 2 | 2 | 4 | ||||||||
MIRT534640 | RNF6 | ring finger protein 6 | 2 | 2 | ||||||||
MIRT537163 | GGCX | gamma-glutamyl carboxylase | 2 | 2 | ||||||||
MIRT539360 | AFF4 | AF4/FMR2 family member 4 | 2 | 2 | ||||||||
MIRT547023 | PPP1CB | protein phosphatase 1 catalytic subunit beta | 2 | 2 | ||||||||
MIRT548155 | FRAT2 | FRAT2, WNT signaling pathway regulator | 2 | 2 | ||||||||
MIRT550127 | ZNF138 | zinc finger protein 138 | 2 | 2 | ||||||||
MIRT558473 | DBN1 | drebrin 1 | 2 | 2 | ||||||||
MIRT566862 | LRRC58 | leucine rich repeat containing 58 | 2 | 2 | ||||||||
MIRT567246 | HSP90AA1 | heat shock protein 90 alpha family class A member 1 | 2 | 2 | ||||||||
MIRT572848 | BRPF3 | bromodomain and PHD finger containing 3 | 2 | 2 | ||||||||
MIRT574914 | Vmp1 | vacuole membrane protein 1 | 2 | 9 | ||||||||
MIRT606849 | RAB7A | RAB7A, member RAS oncogene family | 2 | 2 | ||||||||
MIRT611274 | RBMXL1 | RNA binding motif protein, X-linked like 1 | 2 | 2 | ||||||||
MIRT612328 | TRPS1 | transcriptional repressor GATA binding 1 | 2 | 2 | ||||||||
MIRT612415 | SP1 | Sp1 transcription factor | 2 | 2 | ||||||||
MIRT614791 | RRAGC | Ras related GTP binding C | 2 | 2 | ||||||||
MIRT618449 | SERPINA3 | serpin family A member 3 | 2 | 2 | ||||||||
MIRT621154 | MICALCL | MICAL C-terminal like | 2 | 2 | ||||||||
MIRT622141 | SOX4 | SRY-box 4 | 2 | 2 | ||||||||
MIRT623504 | KCNK5 | potassium two pore domain channel subfamily K member 5 | 2 | 2 | ||||||||
MIRT623598 | IPO9 | importin 9 | 2 | 2 | ||||||||
MIRT624075 | EBF1 | early B-cell factor 1 | 2 | 2 | ||||||||
MIRT639792 | MVK | mevalonate kinase | 2 | 2 | ||||||||
MIRT641109 | ZNF274 | zinc finger protein 274 | 2 | 2 | ||||||||
MIRT641579 | RFX1 | regulatory factor X1 | 2 | 2 | ||||||||
MIRT643095 | NDUFB5 | NADH:ubiquinone oxidoreductase subunit B5 | 2 | 2 | ||||||||
MIRT645141 | CUBN | cubilin | 2 | 2 | ||||||||
MIRT646461 | PRDM10 | PR/SET domain 10 | 2 | 2 | ||||||||
MIRT650815 | HMOX1 | heme oxygenase 1 | 2 | 2 | ||||||||
MIRT653073 | ST8SIA4 | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 | 2 | 2 | ||||||||
MIRT657675 | GPR26 | G protein-coupled receptor 26 | 2 | 2 | ||||||||
MIRT665824 | TIMM8B | translocase of inner mitochondrial membrane 8 homolog B | 2 | 2 | ||||||||
MIRT695592 | TMEM199 | transmembrane protein 199 | 2 | 2 | ||||||||
MIRT698039 | TRPM7 | transient receptor potential cation channel subfamily M member 7 | 2 | 2 | ||||||||
MIRT701015 | PCGF5 | polycomb group ring finger 5 | 2 | 2 | ||||||||
MIRT701357 | NR4A3 | nuclear receptor subfamily 4 group A member 3 | 2 | 2 | ||||||||
MIRT707114 | NWD1 | NACHT and WD repeat domain containing 1 | 2 | 2 | ||||||||
MIRT718661 | HNF4A | hepatocyte nuclear factor 4 alpha | 2 | 2 | ||||||||
MIRT719901 | SERP1 | stress associated endoplasmic reticulum protein 1 | 2 | 2 | ||||||||
MIRT720564 | C1RL | complement C1r subcomponent like | 2 | 2 |