pre-miRNA Information
pre-miRNA hsa-mir-4781   
Genomic Coordinates chr1: 54054079 - 54054154
Description Homo sapiens miR-4781 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4781-3p
Sequence 46| AAUGUUGGAAUCCUCGCUAGAG |67
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs968609764 2 dbSNP
rs899910686 3 dbSNP
rs74085143 4 dbSNP
rs550946107 8 dbSNP
rs747064911 10 dbSNP
rs1352517651 13 dbSNP
rs1436072914 22 dbSNP
Putative Targets

Gene Information
Gene Symbol ATP8B1   
Synonyms ATPIC, BRIC, FIC1, ICP1, PFIC, PFIC1
Description ATPase phospholipid transporting 8B1
Transcript NM_005603   
Expression
Putative miRNA Targets on ATP8B1
3'UTR of ATP8B1
(miRNA target sites are highlighted)
>ATP8B1|NM_005603|3'UTR
   1 TCCCTTACCCCCAGGCTGGGATGCGGCCACAAAGCACGTCTATTTTTTTATGAAAGACTCTCAGGACTTTGTGTGTGTGT
  81 GTGAATTGCATTCATCACAAAGATATTGAAGACAATAAATAATCTTTATAACAAACTCCTTGGGTTGGACTATTAAACAA
 161 TAGCAGAGCCAAGAAATAGGACTTTTAAAAGTCCTATTATTCGGCCGGGCGTGGTGGCTCAGGTCTGTAATCCCAGCACT
 241 TTAGGAGGCTGAGGAGGGGAGATCACCTGAGGCCAGGAGTTCGAGACCAGCCCAGCCAACATGGTGAAACCCTGTCTCTA
 321 CCATAAATTAAAAATTAGCCGGGCTTGGTGGTGGGCACCCGTAATCCCACCTATTTGAGAAGCTGAAGCAGAAGAATCGC
 401 TTGAACCTGGGAGATGGAGGTTACAGTGAGCCGAGATTGCGCCACTGCACTCCAGCCTGGGTGACAGAGCAAGACTCTGT
 481 CTTAAGAAAAATTTAAAAATAGGCCGGGCATGGTGGCTCATGCCTGTCATCCTAGCACTTTGGGAGGCCAAGGCAGGTGG
 561 ATCACTTGAGGTCAGGAGACCAGCCCGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCTGGAAAT
 641 CGCTTGAACCTGGGAGGTGGAGGTTCCAGTGAGCCGAGATCGTGGCACTGCACTCCAACCTGAGCAACAGAGTGAGACAC
 721 CAGCTCAAAAAAAATTTTTTAATAATAATAAAAGTCCTATTATTCAACTGGTTATGTACATTATGGTTGAAAGGGAACGT
 801 TTTAATCCAGTCTCAATCCAGGGCAATAGAATTACAAAGCATGTTGTATTTCAGTTCAAATGGTATTGTATTATAAAATT
 881 ACAGTTACATTTTCCTTTCGGTGATCTTCAGCATAATTTCCCAGAGGCCCCTTTTTCCTCCCTATAGGCCATCTTATTAA
 961 CAGATTTTAAAATTTATAGTAATGACAAATGACTTATCAGTGTTCATCATCTGAAAGCTAAGTGGTTCGTTCAATCACTT
1041 TTTCAAAGTTGATAGTAGATTGCATGGTTTCATGTTTCCTCATATTGGTTTATTAATTCTATTTAATCAAGGAAAATAAC
1121 TTCAGATTCCATAAAGTTTCAGTTTATTTTTAGTTTACTACTAGGTGAGATAGCACATTACATACTTTTACTATCAAATA
1201 TTATTTTAGCAGCTTCCCATAGTACCAAATGATTTGATTCCCTACTCTCATTTTTTAAAGCATATAAATATTTATGGGCT
1281 TAAAAAGGGGGTTTTTAAAAACTGAGGATATCAGTAATAAATTGCAGAATATTTTGCAAAGCTTTCTTTTGGAAAGCAAA
1361 CTTTTGTGCCTGCCTATATGCAAAGTATTTTATCAGGGACTTGAACAAAGACCTCACTCTTTTTCACTTGTCTTATGTCG
1441 AGAGAAAAGGTTATTGGCAGCCACATTCCTAAGACTGGGGAATGGTGTGTCCTTTTAAATTTGAAGATAACTTTAGGTAA
1521 TTATGGAAACTCCTCAAAGAGGAGAAAGTAATTTTTTTCCAGACATTTTTCTCATTCTGTGTCTTTCACACACTAGTTTC
1601 CATAGTTCGAGAATTCTGTTTTTTACCATTGGGCTGTGAATGTTCACAATATCAGTCCTGTTGAATTCCTATGAGGTAAT
1681 CACAATGTGTATATGTTCATTTTCTAGGTATGATAAAAGAATGTATGGCTTTTTATTCTGTGGAAGTAAAATCCTGAACG
1761 TTTACAACTTTTCCTTAACTTGTAAATAAAAAATTGTAAGTTTTTTCTTTTTTTACAGAAAACTTAGCTTGTGTAATTCT
1841 GTTAGTTTCAGATTTCTCTCCTGTTTTTGCAAATTGTGGGAAAGATTGACAATGCAAATGTGTCAAAGACATACTGTTGG
1921 GTGCAATATTAACAATTTTAAATGCAAATTTCTTTGGATAAATTATTTCTATATTCTGTAAATCTGAGATTTAATGTATA
2001 TTTTGTTTAAAAAAATGATTTAGTAAAATCTTTGAAAAGTATGATCTTCTAAAGTATTTAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' gaGAUCGCUCCUAAGGUUGUAa 5'
            | |||  ||   ||||||| 
Target 5' gaCCAGCCCGG---CCAACATg 3'
578 - 596 149.00 -10.60
2
miRNA  3' gaGAUC-GCUCCUAAGGUUGUAa 5'
            | || | ||    ||||||| 
Target 5' gaCCAGCCCAG----CCAACATg 3'
285 - 303 142.00 -8.80
3
miRNA  3' gaGAUCGCUCCUA-AGGUUGUAa 5'
            ||  ||: ||| |:||:||| 
Target 5' tcCTTTCGGTGATCTTCAGCATa 3'
893 - 915 132.00 -12.90
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
196131 10 ClinVar
259814 11 ClinVar
327465 102 ClinVar
327464 132 ClinVar
327463 212 ClinVar
888868 242 ClinVar
888867 261 ClinVar
327462 283 ClinVar
888866 292 ClinVar
888865 296 ClinVar
888864 340 ClinVar
327461 426 ClinVar
327460 440 ClinVar
892268 467 ClinVar
327459 503 ClinVar
892267 506 ClinVar
327458 531 ClinVar
327457 587 ClinVar
327456 646 ClinVar
891047 649 ClinVar
327455 651 ClinVar
891046 676 ClinVar
327454 694 ClinVar
891045 727 ClinVar
891044 734 ClinVar
327453 735 ClinVar
891043 735 ClinVar
890489 741 ClinVar
327452 776 ClinVar
890488 799 ClinVar
327451 827 ClinVar
327450 888 ClinVar
890487 899 ClinVar
327449 900 ClinVar
890486 900 ClinVar
327448 968 ClinVar
327447 1083 ClinVar
327446 1095 ClinVar
888781 1133 ClinVar
888780 1243 ClinVar
327445 1254 ClinVar
888779 1333 ClinVar
888778 1403 ClinVar
327444 1509 ClinVar
327443 1524 ClinVar
892213 1546 ClinVar
327442 1553 ClinVar
892212 1629 ClinVar
892211 1676 ClinVar
327441 1723 ClinVar
892210 1796 ClinVar
890983 1833 ClinVar
890982 1851 ClinVar
327440 1937 ClinVar
327439 1940 ClinVar
890981 1945 ClinVar
327438 2016 ClinVar
COSN30457224 19 COSMIC
COSN26967351 42 COSMIC
COSN30496101 69 COSMIC
COSN31516120 681 COSMIC
COSN30165592 726 COSMIC
COSN7364016 734 COSMIC
COSN5846966 876 COSMIC
COSN31582459 899 COSMIC
COSN28797915 900 COSMIC
COSN16323106 1059 COSMIC
COSN15736933 1496 COSMIC
COSN20165228 1856 COSMIC
COSN6128612 1959 COSMIC
COSN31608510 1969 COSMIC
COSN32065624 2043 COSMIC
rs11543269 1723 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1386809611 1 dbSNP
rs771193328 3 dbSNP
rs760856002 4 dbSNP
rs774046723 9 dbSNP
rs147298165 10 dbSNP
rs34255016 11 dbSNP
rs779974721 18 dbSNP
rs368154561 19 dbSNP
rs751020409 20 dbSNP
rs777864999 21 dbSNP
rs993877680 24 dbSNP
rs769849182 25 dbSNP
rs1285338867 26 dbSNP
rs745425804 30 dbSNP
rs1349087865 31 dbSNP
rs961451242 34 dbSNP
rs780822953 37 dbSNP
rs1307270283 38 dbSNP
rs1370392608 41 dbSNP
rs757008562 42 dbSNP
rs1237366937 43 dbSNP
rs764181773 50 dbSNP
rs772277728 50 dbSNP
rs1444335265 58 dbSNP
rs1197597710 63 dbSNP
rs1224795447 69 dbSNP
rs1016586157 70 dbSNP
rs538588768 72 dbSNP
rs775341299 74 dbSNP
rs1488199355 76 dbSNP
rs1259746141 80 dbSNP
rs1035505960 84 dbSNP
rs149870699 84 dbSNP
rs571757518 89 dbSNP
rs1205204173 93 dbSNP
rs886054008 102 dbSNP
rs1379590979 106 dbSNP
rs895374409 106 dbSNP
rs1445228180 112 dbSNP
rs1164932192 113 dbSNP
rs771809399 122 dbSNP
rs1366138138 124 dbSNP
rs1456983955 127 dbSNP
rs745786597 132 dbSNP
rs906619318 142 dbSNP
rs1226710818 173 dbSNP
rs1331161983 175 dbSNP
rs1384175571 178 dbSNP
rs1248720375 180 dbSNP
rs1045065585 183 dbSNP
rs1003679445 186 dbSNP
rs1321146419 188 dbSNP
rs1228283708 192 dbSNP
rs906701406 195 dbSNP
rs1385016924 202 dbSNP
rs1337753141 203 dbSNP
rs1042617630 206 dbSNP
rs762805430 207 dbSNP
rs1196515006 210 dbSNP
rs1237414762 211 dbSNP
rs886054007 212 dbSNP
rs778781391 215 dbSNP
rs1446324720 217 dbSNP
rs945468369 220 dbSNP
rs1254026376 223 dbSNP
rs1398637084 225 dbSNP
rs1170588174 236 dbSNP
rs757204179 242 dbSNP
rs1169520141 253 dbSNP
rs1462757420 254 dbSNP
rs748164178 264 dbSNP
rs1335269417 266 dbSNP
rs1053769944 277 dbSNP
rs1379132318 282 dbSNP
rs11152024 283 dbSNP
rs1297891722 294 dbSNP
rs553050447 296 dbSNP
rs1052369320 331 dbSNP
rs1264007436 338 dbSNP
rs533724646 340 dbSNP
rs1205370011 341 dbSNP
rs566779869 344 dbSNP
rs1482916779 351 dbSNP
rs922433759 352 dbSNP
rs1186584957 354 dbSNP
rs972567457 360 dbSNP
rs548149860 361 dbSNP
rs1192418057 367 dbSNP
rs1429593130 370 dbSNP
rs751781591 374 dbSNP
rs908897485 375 dbSNP
rs1359083672 377 dbSNP
rs983773821 398 dbSNP
rs983310240 399 dbSNP
rs950639125 409 dbSNP
rs1399505275 413 dbSNP
rs1284120852 415 dbSNP
rs1347668699 417 dbSNP
rs1263631539 418 dbSNP
rs1225099181 420 dbSNP
rs1299005275 423 dbSNP
rs1311391064 425 dbSNP
rs192231911 426 dbSNP
rs1262442632 427 dbSNP
rs535849191 433 dbSNP
rs1215309398 435 dbSNP
rs981717390 437 dbSNP
rs1033892597 438 dbSNP
rs867751351 440 dbSNP
rs906816644 441 dbSNP
rs1161854909 442 dbSNP
rs1359223428 444 dbSNP
rs1239447907 448 dbSNP
rs1021116478 456 dbSNP
rs1374962788 458 dbSNP
rs1309374630 462 dbSNP
rs1392359021 465 dbSNP
rs1434672661 466 dbSNP
rs1367319500 479 dbSNP
rs1366707864 486 dbSNP
rs1010169164 491 dbSNP
rs187993447 503 dbSNP
rs1012344771 505 dbSNP
rs1054288138 506 dbSNP
rs1445751438 520 dbSNP
rs1238808473 522 dbSNP
rs550151909 527 dbSNP
rs758654293 531 dbSNP
rs1490695629 534 dbSNP
rs1219000373 541 dbSNP
rs750825665 542 dbSNP
rs1245745140 554 dbSNP
rs1032344503 557 dbSNP
rs1179274254 561 dbSNP
rs532112071 568 dbSNP
rs922544852 584 dbSNP
rs972566150 586 dbSNP
rs317822 587 dbSNP
rs1417245157 593 dbSNP
rs1403658157 598 dbSNP
rs1365213287 605 dbSNP
rs1051934120 606 dbSNP
rs1442690288 613 dbSNP
rs909598536 621 dbSNP
rs1446031797 623 dbSNP
rs1159313217 628 dbSNP
rs1315627822 637 dbSNP
rs1432429347 639 dbSNP
rs900238188 643 dbSNP
rs886054006 646 dbSNP
rs1288737685 649 dbSNP
rs886054005 651 dbSNP
rs1207076311 654 dbSNP
rs984280434 657 dbSNP
rs1192913804 662 dbSNP
rs1490498228 666 dbSNP
rs1184807683 670 dbSNP
rs959189849 676 dbSNP
rs1313116496 678 dbSNP
rs941805252 679 dbSNP
rs1162690572 681 dbSNP
rs1216027919 682 dbSNP
rs1351540189 690 dbSNP
rs886054004 694 dbSNP
rs1033336628 696 dbSNP
rs981798282 699 dbSNP
rs1168786705 711 dbSNP
rs1262767676 718 dbSNP
rs762415048 720 dbSNP
rs547197052 723 dbSNP
rs776278990 727 dbSNP
rs1009704182 728 dbSNP
rs929218129 732 dbSNP
rs528645513 734 dbSNP
rs1283025704 735 dbSNP
rs561633356 735 dbSNP
rs1346699653 736 dbSNP
rs1362041263 739 dbSNP
rs970265600 741 dbSNP
rs1255739968 746 dbSNP
rs1022815393 747 dbSNP
rs1204668570 750 dbSNP
rs1397610647 751 dbSNP
rs990863528 755 dbSNP
rs553671281 759 dbSNP
rs1186938546 760 dbSNP
rs1289126027 763 dbSNP
rs1242842756 770 dbSNP
rs1476424580 774 dbSNP
rs886054003 776 dbSNP
rs1423142429 783 dbSNP
rs958114782 786 dbSNP
rs1032333417 789 dbSNP
rs999563888 793 dbSNP
rs376678355 799 dbSNP
rs369455664 804 dbSNP
rs902747067 804 dbSNP
rs1345323231 810 dbSNP
rs763756871 815 dbSNP
rs1031031120 817 dbSNP
rs1422858292 819 dbSNP
rs889230202 821 dbSNP
rs1051696001 822 dbSNP
rs182819607 827 dbSNP
rs1276908327 828 dbSNP
rs1487372986 835 dbSNP
rs576003762 860 dbSNP
rs1489334027 863 dbSNP
rs1262766361 868 dbSNP
rs1480851156 870 dbSNP
rs1037361884 880 dbSNP
rs1379215220 884 dbSNP
rs939831125 884 dbSNP
rs1476908214 887 dbSNP
rs149436273 888 dbSNP
rs1048256937 891 dbSNP
rs887562438 899 dbSNP
rs4940950 900 dbSNP
rs1225767771 901 dbSNP
rs1324650365 905 dbSNP
rs1047384445 908 dbSNP
rs1325100129 912 dbSNP
rs929001858 915 dbSNP
rs1232948187 920 dbSNP
rs926380352 934 dbSNP
rs1280676697 941 dbSNP
rs1278172315 948 dbSNP
rs1356405592 955 dbSNP
rs1217300412 965 dbSNP
rs886054002 968 dbSNP
rs553164402 983 dbSNP
rs1285309574 986 dbSNP
rs1490531865 989 dbSNP
rs534006599 995 dbSNP
rs775044980 996 dbSNP
rs1449689301 1000 dbSNP
rs572904722 1026 dbSNP
rs747176979 1029 dbSNP
rs554746589 1037 dbSNP
rs1380860114 1051 dbSNP
rs771787293 1053 dbSNP
rs1156768552 1059 dbSNP
rs988797975 1060 dbSNP
rs1379217217 1064 dbSNP
rs958350814 1067 dbSNP
rs775431987 1069 dbSNP
rs1399655482 1079 dbSNP
rs138676107 1083 dbSNP
rs1007747596 1089 dbSNP
rs745597887 1092 dbSNP
rs915692583 1093 dbSNP
rs886054001 1095 dbSNP
rs1476343686 1096 dbSNP
rs568796692 1108 dbSNP
rs1309147241 1125 dbSNP
rs1360314839 1129 dbSNP
rs958104941 1132 dbSNP
rs997437548 1133 dbSNP
rs1355838877 1147 dbSNP
rs368510542 1147 dbSNP
rs1238634935 1153 dbSNP
rs1458916837 1160 dbSNP
rs978074666 1163 dbSNP
rs1237460591 1164 dbSNP
rs1423919500 1164 dbSNP
rs375487501 1181 dbSNP
rs562788964 1188 dbSNP
rs550192390 1191 dbSNP
rs1366362693 1194 dbSNP
rs1036403516 1197 dbSNP
rs190183553 1198 dbSNP
rs368864262 1204 dbSNP
rs888398051 1207 dbSNP
rs1462071783 1212 dbSNP
rs1257813229 1219 dbSNP
rs1464367163 1223 dbSNP
rs1331301847 1240 dbSNP
rs571338678 1243 dbSNP
rs372877419 1247 dbSNP
rs1030353095 1248 dbSNP
rs1048681309 1249 dbSNP
rs1197081676 1250 dbSNP
rs1310581278 1251 dbSNP
rs17685852 1254 dbSNP
rs926328036 1266 dbSNP
rs1228505960 1271 dbSNP
rs1260212169 1286 dbSNP
rs1319782606 1290 dbSNP
rs1046183115 1291 dbSNP
rs772130553 1292 dbSNP
rs949156798 1292 dbSNP
rs528685351 1301 dbSNP
rs913551946 1302 dbSNP
rs1483501943 1306 dbSNP
rs987856800 1308 dbSNP
rs561366413 1310 dbSNP
rs1243465190 1321 dbSNP
rs1422712255 1323 dbSNP
rs1006385714 1334 dbSNP
rs1425281848 1345 dbSNP
rs375349179 1350 dbSNP
rs958516005 1354 dbSNP
rs1170345913 1356 dbSNP
rs1360258057 1361 dbSNP
rs1468091387 1364 dbSNP
rs1301593440 1373 dbSNP
rs1401650054 1376 dbSNP
rs1382817062 1380 dbSNP
rs925574092 1385 dbSNP
rs1338643971 1392 dbSNP
rs1216581835 1400 dbSNP
rs1277260486 1403 dbSNP
rs1047440038 1415 dbSNP
rs986231793 1425 dbSNP
rs1212218738 1427 dbSNP
rs150194818 1428 dbSNP
rs1482663268 1436 dbSNP
rs531264150 1437 dbSNP
rs1216646335 1438 dbSNP
rs770785019 1439 dbSNP
rs997553770 1440 dbSNP
rs563949637 1449 dbSNP
rs185673102 1454 dbSNP
rs1304225659 1461 dbSNP
rs1435257664 1464 dbSNP
rs1329061538 1465 dbSNP
rs1968274 1509 dbSNP
rs375448281 1520 dbSNP
rs1420404897 1522 dbSNP
rs886054000 1524 dbSNP
rs1358864152 1536 dbSNP
rs1399698974 1540 dbSNP
rs1457510135 1542 dbSNP
rs1383423114 1546 dbSNP
rs1002000126 1549 dbSNP
rs559805305 1553 dbSNP
rs1299139601 1559 dbSNP
rs1311478062 1560 dbSNP
rs1045409855 1564 dbSNP
rs948633882 1565 dbSNP
rs758308099 1590 dbSNP
rs1215508414 1600 dbSNP
rs1046298742 1603 dbSNP
rs949103874 1608 dbSNP
rs892241042 1609 dbSNP
rs1189794261 1611 dbSNP
rs1267285235 1618 dbSNP
rs1052505143 1619 dbSNP
rs1237729348 1626 dbSNP
rs367994135 1629 dbSNP
rs936361644 1651 dbSNP
rs1419144510 1655 dbSNP
rs1054270241 1661 dbSNP
rs925491749 1669 dbSNP
rs986346595 1671 dbSNP
rs932274962 1676 dbSNP
rs923432538 1686 dbSNP
rs1291510421 1691 dbSNP
rs1369976575 1719 dbSNP
rs1447498792 1720 dbSNP
rs11543269 1723 dbSNP
rs966824773 1725 dbSNP
rs768661400 1726 dbSNP
rs1209734808 1728 dbSNP
rs1353731543 1729 dbSNP
rs923233743 1738 dbSNP
rs1323087248 1746 dbSNP
rs372509568 1759 dbSNP
rs1293305798 1760 dbSNP
rs1458481797 1773 dbSNP
rs1181106340 1777 dbSNP
rs1245998439 1791 dbSNP
rs747148347 1796 dbSNP
rs528807266 1800 dbSNP
rs1444136054 1809 dbSNP
rs1164329344 1810 dbSNP
rs1336102702 1827 dbSNP
rs1322854627 1828 dbSNP
rs1333321098 1830 dbSNP
rs574070627 1833 dbSNP
rs1440855978 1837 dbSNP
rs952190033 1842 dbSNP
rs1363848066 1845 dbSNP
rs1165557130 1847 dbSNP
rs1425339940 1851 dbSNP
rs1272118646 1869 dbSNP
rs1379942696 1875 dbSNP
rs1157026269 1878 dbSNP
rs952082684 1881 dbSNP
rs1034390534 1886 dbSNP
rs1211439243 1887 dbSNP
rs906986083 1891 dbSNP
rs1471839009 1893 dbSNP
rs1045806545 1894 dbSNP
rs1012607219 1908 dbSNP
rs1271599571 1910 dbSNP
rs780094474 1911 dbSNP
rs1478038043 1921 dbSNP
rs1002114816 1923 dbSNP
rs1172477526 1936 dbSNP
rs1129621 1937 dbSNP
rs117693241 1940 dbSNP
rs935923283 1942 dbSNP
rs779489096 1945 dbSNP
rs1225079681 1952 dbSNP
rs1292324714 1955 dbSNP
rs1340687726 1957 dbSNP
rs892179490 1969 dbSNP
rs1220856435 1970 dbSNP
rs1276778498 1971 dbSNP
rs1339127923 1983 dbSNP
rs1052196266 1984 dbSNP
rs1041581460 1995 dbSNP
rs1281310463 2009 dbSNP
rs78208201 2009 dbSNP
rs1440802943 2013 dbSNP
rs35833803 2016 dbSNP
rs575186756 2016 dbSNP
rs1489354364 2017 dbSNP
rs1191773636 2025 dbSNP
rs556806766 2043 dbSNP
rs1303641499 2051 dbSNP
rs538259234 2054 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 5205.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM1065667. RNA binding protein: AGO1. Condition:4-thiouridine ...

- Memczak S; Jens M; Elefsinioti A; Torti F; et al., 2013, Nature.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' gagaucgcuccuaaGGUUGUAa 5'
                        ||||||| 
Target 5' -----------cggCCAACAUg 3'
1 - 11
Article - Memczak S; Jens M; Elefsinioti A; Torti F; et al.
- Nature, 2013
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.
LinkOut: [PMID: 23446348]
CLIP-seq Support 1 for dataset GSM4903834
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_b
Location of target site NM_005603 | 3UTR | CCGGCCAACAUGGUGAAACC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1065667
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / 4-thiouridine, ML_MM_6
Location of target site ENST00000283684.4 | 3UTR | CGGCCAACAUGGUGAAACCCCAUC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
204 hsa-miR-4781-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT071728 CCNK cyclin K 2 2
MIRT184858 FLVCR1 feline leukemia virus subgroup C cellular receptor 1 2 2
MIRT205881 TNRC6B trinucleotide repeat containing 6B 2 2
MIRT218699 ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A 2 2
MIRT223783 OXR1 oxidation resistance 1 2 2
MIRT242435 GAN gigaxonin 2 2
MIRT306825 NCBP2 nuclear cap binding protein subunit 2 2 2
MIRT334170 CCND1 cyclin D1 2 6
MIRT339617 TMPO thymopoietin 2 2
MIRT400371 C2ORF68 chromosome 2 open reading frame 68 2 2
MIRT445533 KIF1B kinesin family member 1B 2 4
MIRT450273 F2RL2 coagulation factor II thrombin receptor like 2 2 2
MIRT450701 RORA RAR related orphan receptor A 2 2
MIRT451160 C19orf53 chromosome 19 open reading frame 53 2 2
MIRT453775 NUCB1 nucleobindin 1 2 10
MIRT453884 IFRD1 interferon related developmental regulator 1 2 12
MIRT454238 OSBPL10 oxysterol binding protein like 10 2 9
MIRT458661 PAGR1 PAXIP1 associated glutamate rich protein 1 2 12
MIRT466948 STAU1 staufen double-stranded RNA binding protein 1 2 2
MIRT470278 PRKAA1 protein kinase AMP-activated catalytic subunit alpha 1 2 2
MIRT471144 PHF19 PHD finger protein 19 2 2
MIRT471873 NUFIP2 NUFIP2, FMR1 interacting protein 2 2 2
MIRT476739 FOXN2 forkhead box N2 2 2
MIRT480453 C16orf72 chromosome 16 open reading frame 72 2 6
MIRT482107 AKT3 AKT serine/threonine kinase 3 2 4
MIRT483374 CYP4A22 cytochrome P450 family 4 subfamily A member 22 2 2
MIRT484063 CYP4A11 cytochrome P450 family 4 subfamily A member 11 2 2
MIRT496329 SH3BGRL SH3 domain binding glutamate rich protein like 2 2
MIRT498659 AP3B2 adaptor related protein complex 3 beta 2 subunit 2 4
MIRT498711 PGAM5 PGAM family member 5, mitochondrial serine/threonine protein phosphatase 2 10
MIRT499322 ZNF485 zinc finger protein 485 2 6
MIRT499711 NFATC2IP nuclear factor of activated T-cells 2 interacting protein 2 10
MIRT499767 CIRH1A UTP4, small subunit processome component 2 6
MIRT499912 PIGO phosphatidylinositol glycan anchor biosynthesis class O 2 8
MIRT504946 ZSWIM6 zinc finger SWIM-type containing 6 2 4
MIRT505377 TMEM154 transmembrane protein 154 2 4
MIRT508778 GSG1 germ cell associated 1 2 2
MIRT509793 CHAF1B chromatin assembly factor 1 subunit B 2 4
MIRT512421 LAYN layilin 2 4
MIRT513321 SCUBE3 signal peptide, CUB domain and EGF like domain containing 3 2 2
MIRT513592 DCTN6 dynactin subunit 6 2 2
MIRT514785 RBM4B RNA binding motif protein 4B 2 2
MIRT514859 PTPLAD2 3-hydroxyacyl-CoA dehydratase 4 1 2
MIRT515122 LMOD3 leiomodin 3 2 2
MIRT515271 CSNK1E casein kinase 1 epsilon 2 2
MIRT515594 FBXL13 F-box and leucine rich repeat protein 13 2 2
MIRT515880 PLXDC2 plexin domain containing 2 2 2
MIRT515908 AGTPBP1 ATP/GTP binding protein 1 2 2
MIRT515960 C9orf156 tRNA methyltransferase O 2 2
MIRT517210 OTUD6A OTU deubiquitinase 6A 2 2
MIRT517330 ZNF347 zinc finger protein 347 2 2
MIRT517480 PEX26 peroxisomal biogenesis factor 26 2 2
MIRT517594 ZNF579 zinc finger protein 579 2 4
MIRT517676 TRIM72 tripartite motif containing 72 2 2
MIRT518215 TRMT10B tRNA methyltransferase 10B 2 2
MIRT518583 ATP8B1 ATPase phospholipid transporting 8B1 2 2
MIRT518777 ZFP14 ZFP14 zinc finger protein 2 2
MIRT519094 SLC4A1 solute carrier family 4 member 1 (Diego blood group) 2 4
MIRT519112 ALG1 ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase 2 2
MIRT519400 DNASE2 deoxyribonuclease 2, lysosomal 2 4
MIRT519446 GLA galactosidase alpha 2 2
MIRT519476 SPTLC2 serine palmitoyltransferase long chain base subunit 2 2 2
MIRT519711 ZNF584 zinc finger protein 584 2 4
MIRT521409 RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis) 2 2
MIRT521522 QSOX1 quiescin sulfhydryl oxidase 1 2 2
MIRT522652 MANEAL mannosidase endo-alpha like 2 2
MIRT523505 GMPS guanine monophosphate synthase 2 4
MIRT523795 FAM63B MINDY lysine 48 deubiquitinase 2 2 2
MIRT524062 DNAJC8 DnaJ heat shock protein family (Hsp40) member C8 2 2
MIRT524136 DMXL1 Dmx like 1 2 2
MIRT524192 DENND4C DENN domain containing 4C 2 4
MIRT525925 KIAA0391 KIAA0391 2 2
MIRT528021 ACOT9 acyl-CoA thioesterase 9 2 2
MIRT528685 CEP57L1 centrosomal protein 57 like 1 2 2
MIRT528769 CD1D CD1d molecule 2 2
MIRT529373 YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta 2 4
MIRT529469 ZNF546 zinc finger protein 546 2 2
MIRT529641 ZNF621 zinc finger protein 621 2 2
MIRT530681 CHRNB1 cholinergic receptor nicotinic beta 1 subunit 2 4
MIRT530752 GPR82 G protein-coupled receptor 82 2 2
MIRT531628 TM4SF5 transmembrane 4 L six family member 5 2 4
MIRT531649 C19orf52 translocase of inner mitochondrial membrane 29 2 4
MIRT532179 SEC14L5 SEC14 like lipid binding 5 2 4
MIRT532219 CCDC117 coiled-coil domain containing 117 2 2
MIRT534238 SLC25A16 solute carrier family 25 member 16 2 4
MIRT539952 SLC30A5 solute carrier family 30 member 5 2 2
MIRT540179 MB21D1 Mab-21 domain containing 1 2 2
MIRT540466 ZNF71 zinc finger protein 71 2 2
MIRT540560 PPIC peptidylprolyl isomerase C 2 2
MIRT543265 ZNF662 zinc finger protein 662 2 2
MIRT543596 KIAA1549 KIAA1549 2 2
MIRT543971 RNF20 ring finger protein 20 2 2
MIRT544053 C9orf64 chromosome 9 open reading frame 64 2 2
MIRT544605 DCAF5 DDB1 and CUL4 associated factor 5 2 2
MIRT544679 AP1S1 adaptor related protein complex 1 sigma 1 subunit 2 2
MIRT547627 LCOR ligand dependent nuclear receptor corepressor 2 2
MIRT550668 TRAF1 TNF receptor associated factor 1 2 2
MIRT551533 EMB embigin 2 2
MIRT552443 ZNF449 zinc finger protein 449 2 2
MIRT559265 BAG4 BCL2 associated athanogene 4 2 4
MIRT562479 CHORDC1 cysteine and histidine rich domain containing 1 2 2
MIRT564211 SDE2 SDE2 telomere maintenance homolog 2 2
MIRT565973 RPP14 ribonuclease P/MRP subunit p14 2 2
MIRT570524 SHH sonic hedgehog 2 2
MIRT575307 Osbpl10 oxysterol binding protein-like 10 2 6
MIRT618212 C22orf39 chromosome 22 open reading frame 39 2 2
MIRT620115 HARBI1 harbinger transposase derived 1 2 2
MIRT624062 EIF4E eukaryotic translation initiation factor 4E 2 2
MIRT626083 CWF19L1 CWF19 like 1, cell cycle control (S. pombe) 2 2
MIRT629868 GATAD1 GATA zinc finger domain containing 1 2 2
MIRT630750 COG6 component of oligomeric golgi complex 6 2 2
MIRT631002 ZNF573 zinc finger protein 573 2 2
MIRT631100 UQCRB ubiquinol-cytochrome c reductase binding protein 2 2
MIRT631290 SGSM1 small G protein signaling modulator 1 2 2
MIRT631337 CD300E CD300e molecule 2 2
MIRT631532 MYO6 myosin VI 2 2
MIRT631644 WDR91 WD repeat domain 91 2 4
MIRT632788 LZIC leucine zipper and CTNNBIP1 domain containing 2 2
MIRT633282 FGFR1OP2 FGFR1 oncogene partner 2 2 2
MIRT633593 ABRACL ABRA C-terminal like 2 2
MIRT634074 PLIN3 perilipin 3 2 2
MIRT634163 YME1L1 YME1 like 1 ATPase 2 2
MIRT634257 TIAL1 TIA1 cytotoxic granule associated RNA binding protein like 1 2 2
MIRT634679 GDE1 glycerophosphodiester phosphodiesterase 1 2 2
MIRT638384 RABL3 RAB, member of RAS oncogene family like 3 2 2
MIRT638687 GCLM glutamate-cysteine ligase modifier subunit 2 2
MIRT640311 PRR13 proline rich 13 2 2
MIRT641132 NPHP3 nephrocystin 3 2 2
MIRT642315 FPR1 formyl peptide receptor 1 2 2
MIRT643703 KIAA0586 KIAA0586 2 2
MIRT644322 NFKBID NFKB inhibitor delta 2 2
MIRT645741 POLR3A RNA polymerase III subunit A 2 2
MIRT646975 CYP2W1 cytochrome P450 family 2 subfamily W member 1 2 2
MIRT648064 TRMT10C tRNA methyltransferase 10C, mitochondrial RNase P subunit 2 2
MIRT648536 CHCHD4 coiled-coil-helix-coiled-coil-helix domain containing 4 2 2
MIRT649294 NEK8 NIMA related kinase 8 2 2
MIRT650014 KLB klotho beta 2 2
MIRT650551 YIPF4 Yip1 domain family member 4 2 2
MIRT651796 UTP6 UTP6, small subunit processome component 2 2
MIRT652647 TIMM10 translocase of inner mitochondrial membrane 10 2 2
MIRT653548 SLC38A7 solute carrier family 38 member 7 2 2
MIRT653895 SGK3 serum/glucocorticoid regulated kinase family member 3 2 2
MIRT655470 PAK3 p21 (RAC1) activated kinase 3 2 2
MIRT657764 GMEB1 glucocorticoid modulatory element binding protein 1 2 2
MIRT659118 DENND6A DENN domain containing 6A 2 2
MIRT659377 CREG2 cellular repressor of E1A stimulated genes 2 2 2
MIRT659836 CARHSP1 calcium regulated heat stable protein 1 2 2
MIRT659954 C8orf44-SGK3 C8orf44-SGK3 readthrough 2 2
MIRT660258 BLOC1S6 biogenesis of lysosomal organelles complex 1 subunit 6 2 2
MIRT663268 ATP1A2 ATPase Na+/K+ transporting subunit alpha 2 2 2
MIRT663766 ZNF285 zinc finger protein 285 2 2
MIRT666198 SMCR8 Smith-Magenis syndrome chromosome region, candidate 8 2 2
MIRT669763 ZNF101 zinc finger protein 101 2 4
MIRT669933 LRPAP1 LDL receptor related protein associated protein 1 2 2
MIRT670007 GPR156 G protein-coupled receptor 156 2 4
MIRT670465 RSBN1L round spermatid basic protein 1 like 2 2
MIRT670868 IFNAR1 interferon alpha and beta receptor subunit 1 2 4
MIRT671313 RABGAP1L RAB GTPase activating protein 1 like 2 2
MIRT671959 SPPL3 signal peptide peptidase like 3 2 2
MIRT672281 SHE Src homology 2 domain containing E 2 2
MIRT673654 CYCS cytochrome c, somatic 2 2
MIRT674063 ATXN3 ataxin 3 2 2
MIRT674423 IPP intracisternal A particle-promoted polypeptide 2 2
MIRT674438 MIOX myo-inositol oxygenase 2 4
MIRT674483 BCL2L15 BCL2 like 15 2 2
MIRT675478 NUBPL nucleotide binding protein like 2 2
MIRT675648 TTPAL alpha tocopherol transfer protein like 2 2
MIRT675981 FAM126B family with sequence similarity 126 member B 2 2
MIRT676251 PARP2 poly(ADP-ribose) polymerase 2 2 2
MIRT677652 HAUS2 HAUS augmin like complex subunit 2 2 2
MIRT682718 KIAA1456 KIAA1456 2 2
MIRT687545 MOB1B MOB kinase activator 1B 2 2
MIRT689620 AKAP6 A-kinase anchoring protein 6 2 2
MIRT690035 CCDC90B coiled-coil domain containing 90B 2 2
MIRT691449 CXorf36 chromosome X open reading frame 36 2 2
MIRT691549 FLYWCH2 FLYWCH family member 2 2 2
MIRT691737 LARS leucyl-tRNA synthetase 2 2
MIRT692638 SUSD1 sushi domain containing 1 2 2
MIRT693866 IYD iodotyrosine deiodinase 2 2
MIRT693979 ZNF70 zinc finger protein 70 2 2
MIRT694150 CYP27C1 cytochrome P450 family 27 subfamily C member 1 2 2
MIRT695492 TRAT1 T-cell receptor associated transmembrane adaptor 1 2 2
MIRT695547 MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2 2 2
MIRT696023 TYRO3 TYRO3 protein tyrosine kinase 2 2
MIRT696402 CORO7 coronin 7 2 2
MIRT703028 HEATR5A HEAT repeat containing 5A 2 2
MIRT703559 FKBP14 FK506 binding protein 14 2 2
MIRT705036 CACUL1 CDK2 associated cullin domain 1 2 2
MIRT705120 C4orf29 abhydrolase domain containing 18 2 2
MIRT706611 CYB5B cytochrome b5 type B 2 2
MIRT706635 PNPT1 polyribonucleotide nucleotidyltransferase 1 2 2
MIRT706730 RFK riboflavin kinase 2 2
MIRT706868 MAFF MAF bZIP transcription factor F 2 2
MIRT707020 RRP36 ribosomal RNA processing 36 2 2
MIRT707036 ACTR5 ARP5 actin related protein 5 homolog 2 2
MIRT707125 ZNF154 zinc finger protein 154 2 2
MIRT707390 SLC35F6 solute carrier family 35 member F6 2 2
MIRT708664 LYRM7 LYR motif containing 7 2 2
MIRT713010 BBX BBX, HMG-box containing 2 2
MIRT717314 TRAF3IP1 TRAF3 interacting protein 1 2 2
MIRT721912 C6orf201 chromosome 6 open reading frame 201 2 2
MIRT723050 YTHDC1 YTH domain containing 1 2 2
MIRT725038 NDUFAF7 NADH:ubiquinone oxidoreductase complex assembly factor 7 2 2
MIRT755316 SMAD5 SMAD family member 5 4 1
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4781-3p Gefitinib 123631 NSC715055 approved resistant cell line (PC9)
hsa-miR-4781-3p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-4781-3p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-4781-3p Osimertinib 71496458 NSC779217 approved sensitive cell line (HCC827)

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