pre-miRNA Information | |
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pre-miRNA | hsa-mir-125b-2 |
Genomic Coordinates | chr21: 16590237 - 16590325 |
Synonyms | MIRN125B2, MIR125B2 |
Description | Homo sapiens miR-125b-2 stem-loop |
Comment | This miRNA sequence is predicted based on homology to a verified miRNA from mouse . |
RNA Secondary Structure | ![]() |
Associated Diseases | ![]() |
Mature miRNA Information | |||||||||||||||
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Mature miRNA | hsa-miR-125b-2-3p | ||||||||||||||
Sequence | 54| UCACAAGUCAGGCUCUUGGGAC |75 | ||||||||||||||
Evidence | Experimental | ||||||||||||||
Experiments | Cloned | ||||||||||||||
Editing Events in miRNAs |
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SNPs in miRNA |
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Putative Targets |
miRNA Expression profile | |
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Human miRNA Tissue Atlas | |
miRNAs in Extracellular Vesicles |
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Circulating MicroRNA Expression Profiling |
Gene Information | |||||||||||||||||||||
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Gene Symbol | LSG1 | ||||||||||||||||||||
Synonyms | - | ||||||||||||||||||||
Description | large 60S subunit nuclear export GTPase 1 | ||||||||||||||||||||
Transcript | NM_018385 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on LSG1 | |||||||||||||||||||||
3'UTR of LSG1 (miRNA target sites are highlighted) |
>LSG1|NM_018385|3'UTR 1 GGTTGGGCTGCAACAGAAATGTCATCTGCATTGTGCAGATGGAAAAGAGCAGAAGCTGCCTGTTGCCTGTGGAACCGTCC 81 CAAGACACTAGCACTGTAGAACGGGCCCTGCTCTTGCAGAGCACGGCTGCACCCAACAGTCTCCATGTCAAGACCAAGGG 161 CCTCCTGGAAACACCAACTCTGACAAAAAGGAGTCATCTGGGAGCCCGAGAATCCTACTCCTGGCCGGGCACAGTGGCTC 241 ACGCACCAACATGGAGAAACCCCGTCTCTACTAAAAATACAAAAAAATTAGCCAGGCGTGGTGGCGCGCACCTGTAATCC 321 CAGCTACTCGGGAGGCTGAGGCAGGAGAATCACTTGAACCAGGGAGGCAGAGTTTGCAGTGAATGGAGATTGCGCCGCTG 401 CACTCCAGCCTGGGCGACAGAGTGAGACTGCATCACAAGAAAAAAAATTTGCAAGGGATGGTTCACGAGACACATTTGGG 481 ACGAAGGTGAAAGAGAAATTCCCCATTCTGAGTGTCCTAGTTGGGTTCCTCCGACTCTAAACAAGGGACTTGGGTTCAGT 561 TAGTGTACAGCGGGGGCTCACGTCCACTAAGGAACATGTAGAATGTAACCACCGGGTGACAGGGAAGCTGCGGTATTTAC 641 TACCTAGCCCCCATCTTCACTGGTTATTCCACTTATTTAAAATGTCCAGAATAAGCAAATCTCCATATAGAGGAAGTAGA 721 TTAGTGGTTGCTTCGGGATGGGAGGAATGGGAAGATTGAGGTCTTTCTTTTGCAGTGATAAAAATGTCCTAAAATTGACT 801 GTAGCGATGGTCACACAACTCTGAATATGCTTAAGACCATTGAATTACACACTTTACGTTGGTGAATTGTATGGTATGTA 881 AATTATAGTTCAATAACATAGTTACAAAAGATAATCAAAAGCATGAAAGCACTGTTGATGTGGTTTGGATCTGTGTCCTC 961 ACCGAGTCTCATGTTGAAATGTAAGCCCCCTGGTGGGAGGCGATGGGATTATGGGGCAGAGTCCTCACGAACGGTTTAGC 1041 ACCACCCGCTCAGTGCTGTTCTCCTGATATTGAGTCCTCATCACATCTGGTTGCTTCAAAGTGTGTGGTGCCTCCCCTCT 1121 GTCTCCCTCCTGCTCTGGCCATATAAGATGTGCCTGCTTCTCCTTCGCCTTCTAACATGATTGTAAGTTTCCTGAGGCCT 1201 CCCTAGAAGCAAAAGCTGCTGTGCTTCCTGTACCATCTACAGGACCGTGAGCCAATTAAACCTCTTTTCTTTATAAATTA 1281 AAAAAAAAAAAAAAAAA Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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DRVs in gene 3'UTRs | |||||||||||||||||||||
SNPs in gene 3'UTRs |
Experimental Support 1 for Functional miRNA-Target Interaction | |||||||
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miRNA:Target | ---- | ||||||
Validation Method |
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Conditions | HEK293 | ||||||
Disease | 55341.0 | ||||||
Location of target site | 3'UTR | ||||||
Tools used in this research | TargetScan , miRTarCLIP , Piranha | ||||||
Original Description (Extracted from the article) |
...
"PAR-CLIP data was present in GSM1065667. RNA binding protein: AGO1. Condition:4-thiouridine
... - Memczak S; Jens M; Elefsinioti A; Torti F; et al., 2013, Nature. |
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miRNA-target interactions (Provided by authors) |
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Article |
- Memczak S; Jens M; Elefsinioti A; Torti F; et al. - Nature, 2013
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.
LinkOut: [PMID: 23446348]
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CLIP-seq Support 1 for dataset GSM1065667 | |
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Method / RBP | PAR-CLIP / AGO1 |
Cell line / Condition | HEK293 / 4-thiouridine, ML_MM_6 |
Location of target site | ENST00000265245.5 | 3UTR | AUCCGCCCACCCUGGCCUCCCAAAG |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23446348 / GSE43573 |
CLIP-seq Viewer | Link |
MiRNA-Target Expression Profile | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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MiRNA-Target Expression Profile (TCGA) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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91 hsa-miR-125b-2-3p Target Genes:
Functional analysis:
ID![]() |
Target | Description | Validation methods |
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Strong evidence | Less strong evidence | |||||||||||
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MIRT038624 | HN1L | Jupiter microtubule associated homolog 2 | ![]() |
1 | 1 | |||||||
MIRT038625 | KDELC2 | KDEL motif containing 2 | ![]() |
1 | 1 | |||||||
MIRT038626 | ABHD15 | abhydrolase domain containing 15 | ![]() |
1 | 1 | |||||||
MIRT038627 | PPP1R12C | protein phosphatase 1 regulatory subunit 12C | ![]() |
1 | 1 | |||||||
MIRT038628 | MSANTD4 | Myb/SANT DNA binding domain containing 4 with coiled-coils | ![]() |
1 | 1 | |||||||
MIRT038629 | ASH2L | ASH2 like histone lysine methyltransferase complex subunit | ![]() |
1 | 1 | |||||||
MIRT038630 | USP22 | ubiquitin specific peptidase 22 | ![]() |
1 | 1 | |||||||
MIRT038631 | CSTB | cystatin B | ![]() |
1 | 1 | |||||||
MIRT038632 | SYT2 | synaptotagmin 2 | ![]() |
1 | 1 | |||||||
MIRT038633 | NDUFS7 | NADH:ubiquinone oxidoreductase core subunit S7 | ![]() |
1 | 1 | |||||||
MIRT038634 | MTA2 | metastasis associated 1 family member 2 | ![]() |
1 | 1 | |||||||
MIRT053086 | IGF1R | insulin like growth factor 1 receptor | ![]() |
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3 | 1 | |||||
MIRT055788 | PLEKHA1 | pleckstrin homology domain containing A1 | ![]() |
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2 | 12 | ||||||
MIRT061248 | AMOTL1 | angiomotin like 1 | ![]() |
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2 | 10 | ||||||
MIRT061649 | BTG2 | BTG anti-proliferation factor 2 | ![]() |
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2 | 6 | ||||||
MIRT079046 | TNRC6C | trinucleotide repeat containing 6C | ![]() |
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2 | 4 | ||||||
MIRT084583 | BCL2L11 | BCL2 like 11 | ![]() |
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2 | 8 | ||||||
MIRT093523 | GALNT7 | polypeptide N-acetylgalactosaminyltransferase 7 | ![]() |
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2 | 2 | ||||||
MIRT097383 | LHFPL2 | LHFPL tetraspan subfamily member 2 | ![]() |
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2 | 4 | ||||||
MIRT098030 | SOBP | sine oculis binding protein homolog | ![]() |
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2 | 2 | ||||||
MIRT186262 | TCEB3 | elongin A | ![]() |
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2 | 2 | ||||||
MIRT187284 | DAZAP2 | DAZ associated protein 2 | ![]() |
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2 | 10 | ||||||
MIRT361113 | LRRC1 | leucine rich repeat containing 1 | ![]() |
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2 | 2 | ||||||
MIRT443585 | FAM84B | family with sequence similarity 84 member B | ![]() |
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2 | 2 | ||||||
MIRT452249 | TRAM1 | translocation associated membrane protein 1 | ![]() |
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2 | 2 | ||||||
MIRT476289 | GMFB | glia maturation factor beta | ![]() |
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2 | 8 | ||||||
MIRT483871 | MRPL12 | mitochondrial ribosomal protein L12 | ![]() |
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2 | 2 | ||||||
MIRT484250 | ANK1 | ankyrin 1 | ![]() |
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2 | 2 | ||||||
MIRT499251 | VAV3 | vav guanine nucleotide exchange factor 3 | ![]() |
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2 | 4 | ||||||
MIRT502270 | HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | ![]() |
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2 | 4 | ||||||
MIRT504652 | RPL9 | ribosomal protein L9 | ![]() |
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2 | 6 | ||||||
MIRT505210 | UBN2 | ubinuclein 2 | ![]() |
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2 | 6 | ||||||
MIRT512690 | POP1 | POP1 homolog, ribonuclease P/MRP subunit | ![]() |
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2 | 2 | ||||||
MIRT517341 | ZNF529 | zinc finger protein 529 | ![]() |
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2 | 4 | ||||||
MIRT518946 | LSG1 | large 60S subunit nuclear export GTPase 1 | ![]() |
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2 | 2 | ||||||
MIRT520866 | SUGT1 | SGT1 homolog, MIS12 kinetochore complex assembly cochaperone | ![]() |
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2 | 2 | ||||||
MIRT521236 | SAR1A | secretion associated Ras related GTPase 1A | ![]() |
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2 | 2 | ||||||
MIRT528324 | GIGYF2 | GRB10 interacting GYF protein 2 | ![]() |
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2 | 2 | ||||||
MIRT533297 | USP46 | ubiquitin specific peptidase 46 | ![]() |
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2 | 2 | ||||||
MIRT541024 | WEE1 | WEE1 G2 checkpoint kinase | ![]() |
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2 | 4 | ||||||
MIRT544034 | ERRFI1 | ERBB receptor feedback inhibitor 1 | ![]() |
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2 | 2 | ||||||
MIRT547037 | POGZ | pogo transposable element derived with ZNF domain | ![]() |
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2 | 2 | ||||||
MIRT556102 | MOAP1 | modulator of apoptosis 1 | ![]() |
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2 | 2 | ||||||
MIRT558320 | DR1 | down-regulator of transcription 1 | ![]() |
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2 | 2 | ||||||
MIRT558520 | CSRNP3 | cysteine and serine rich nuclear protein 3 | ![]() |
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2 | 2 | ||||||
MIRT566230 | PTMA | prothymosin, alpha | ![]() |
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2 | 4 | ||||||
MIRT568437 | ARPP19 | cAMP regulated phosphoprotein 19 | ![]() |
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2 | 2 | ||||||
MIRT570584 | OTUD7B | OTU deubiquitinase 7B | ![]() |
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2 | 2 | ||||||
MIRT571384 | JKAMP | JNK1/MAPK8-associated membrane protein | ![]() |
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2 | 2 | ||||||
MIRT572798 | SIGLEC14 | sialic acid binding Ig like lectin 14 | ![]() |
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2 | 2 | ||||||
MIRT573864 | C9orf78 | chromosome 9 open reading frame 78 | ![]() |
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2 | 2 | ||||||
MIRT609930 | SLC38A1 | solute carrier family 38 member 1 | ![]() |
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2 | 4 | ||||||
MIRT610437 | CSMD2 | CUB and Sushi multiple domains 2 | ![]() |
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2 | 2 | ||||||
MIRT614407 | MURC | caveolae associated protein 4 | ![]() |
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2 | 2 | ||||||
MIRT618625 | GREB1 | growth regulation by estrogen in breast cancer 1 | ![]() |
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2 | 2 | ||||||
MIRT620605 | SAP30 | Sin3A associated protein 30 | ![]() |
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2 | 2 | ||||||
MIRT635313 | FAM179A | TOG array regulator of axonemal microtubules 2 | ![]() |
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2 | 2 | ||||||
MIRT635918 | GLTSCR2 | NOP53 ribosome biogenesis factor | ![]() |
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2 | 2 | ||||||
MIRT638507 | MAP3K9 | mitogen-activated protein kinase kinase kinase 9 | ![]() |
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2 | 2 | ||||||
MIRT640597 | TM9SF4 | transmembrane 9 superfamily member 4 | ![]() |
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2 | 2 | ||||||
MIRT644066 | IQCE | IQ motif containing E | ![]() |
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2 | 2 | ||||||
MIRT648287 | TRAPPC2L | trafficking protein particle complex 2 like | ![]() |
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2 | 2 | ||||||
MIRT653089 | SSR3 | signal sequence receptor subunit 3 | ![]() |
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2 | 2 | ||||||
MIRT654651 | PTAFR | platelet activating factor receptor | ![]() |
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2 | 2 | ||||||
MIRT658084 | FOXR2 | forkhead box R2 | ![]() |
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2 | 2 | ||||||
MIRT665306 | ZBTB37 | zinc finger and BTB domain containing 37 | ![]() |
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2 | 2 | ||||||
MIRT665974 | SYTL4 | synaptotagmin like 4 | ![]() |
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2 | 2 | ||||||
MIRT674905 | RASSF9 | Ras association domain family member 9 | ![]() |
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2 | 2 | ||||||
MIRT680085 | THAP1 | THAP domain containing 1 | ![]() |
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2 | 2 | ||||||
MIRT681487 | DIP2A | disco interacting protein 2 homolog A | ![]() |
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2 | 2 | ||||||
MIRT691243 | DFNB59 | pejvakin | ![]() |
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2 | 2 | ||||||
MIRT692361 | AGTRAP | angiotensin II receptor associated protein | ![]() |
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2 | 2 | ||||||
MIRT693034 | MB21D1 | Mab-21 domain containing 1 | ![]() |
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2 | 2 | ||||||
MIRT694478 | LRTOMT | leucine rich transmembrane and O-methyltransferase domain containing | ![]() |
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2 | 2 | ||||||
MIRT696069 | ZNF264 | zinc finger protein 264 | ![]() |
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2 | 2 | ||||||
MIRT696579 | TTC21B | tetratricopeptide repeat domain 21B | ![]() |
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2 | 2 | ||||||
MIRT696759 | MTFMT | mitochondrial methionyl-tRNA formyltransferase | ![]() |
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2 | 2 | ||||||
MIRT697306 | ZNF652 | zinc finger protein 652 | ![]() |
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2 | 2 | ||||||
MIRT698736 | STX12 | syntaxin 12 | ![]() |
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2 | 2 | ||||||
MIRT701055 | PARP2 | poly(ADP-ribose) polymerase 2 | ![]() |
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2 | 2 | ||||||
MIRT701197 | OTUD3 | OTU deubiquitinase 3 | ![]() |
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2 | 2 | ||||||
MIRT701334 | NSD1 | nuclear receptor binding SET domain protein 1 | ![]() |
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2 | 2 | ||||||
MIRT703617 | FBXO45 | F-box protein 45 | ![]() |
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2 | 2 | ||||||
MIRT708893 | ZNF780A | zinc finger protein 780A | ![]() |
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2 | 2 | ||||||
MIRT711621 | DGKH | diacylglycerol kinase eta | ![]() |
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2 | 2 | ||||||
MIRT713744 | TMEM81 | transmembrane protein 81 | ![]() |
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2 | 2 | ||||||
MIRT715060 | TMTC1 | transmembrane and tetratricopeptide repeat containing 1 | ![]() |
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2 | 2 | ||||||
MIRT719711 | CD101 | CD101 molecule | ![]() |
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2 | 2 | ||||||
MIRT720293 | DLGAP3 | DLG associated protein 3 | ![]() |
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2 | 2 | ||||||
MIRT722605 | CCDC152 | coiled-coil domain containing 152 | ![]() |
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2 | 2 | ||||||
MIRT724565 | ACSBG1 | acyl-CoA synthetase bubblegum family member 1 | ![]() |
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2 | 2 |
miRNA-Drug Associations | ||||||||||||||||||
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miRNA-Drug Resistance Associations | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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