miRTarBase - #MIRT518947


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pre-miRNA Information
pre-miRNA hsa-mir-4457   
Genomic Coordinates chr5: 1309310 - 1309377
Description Homo sapiens miR-4457 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4457
Sequence 43| UCACAAGGUAUUGACUGGCGUA |64
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1031676297 8 dbSNP
rs1249861366 14 dbSNP
rs115769169 17 dbSNP
rs968846507 19 dbSNP
rs540870271 20 dbSNP
rs993130937 22 dbSNP
Putative Targets

Gene Information
Gene Symbol LSG1   
Synonyms -
Description large 60S subunit nuclear export GTPase 1
Transcript NM_018385   
Expression
Putative miRNA Targets on LSG1
3'UTR of LSG1
(miRNA target sites are highlighted)		 
>LSG1|NM_018385|3'UTR
   1 GGTTGGGCTGCAACAGAAATGTCATCTGCATTGTGCAGATGGAAAAGAGCAGAAGCTGCCTGTTGCCTGTGGAACCGTCC
  81 CAAGACACTAGCACTGTAGAACGGGCCCTGCTCTTGCAGAGCACGGCTGCACCCAACAGTCTCCATGTCAAGACCAAGGG
 161 CCTCCTGGAAACACCAACTCTGACAAAAAGGAGTCATCTGGGAGCCCGAGAATCCTACTCCTGGCCGGGCACAGTGGCTC
 241 ACGCACCAACATGGAGAAACCCCGTCTCTACTAAAAATACAAAAAAATTAGCCAGGCGTGGTGGCGCGCACCTGTAATCC
 321 CAGCTACTCGGGAGGCTGAGGCAGGAGAATCACTTGAACCAGGGAGGCAGAGTTTGCAGTGAATGGAGATTGCGCCGCTG
 401 CACTCCAGCCTGGGCGACAGAGTGAGACTGCATCACAAGAAAAAAAATTTGCAAGGGATGGTTCACGAGACACATTTGGG
 481 ACGAAGGTGAAAGAGAAATTCCCCATTCTGAGTGTCCTAGTTGGGTTCCTCCGACTCTAAACAAGGGACTTGGGTTCAGT
 561 TAGTGTACAGCGGGGGCTCACGTCCACTAAGGAACATGTAGAATGTAACCACCGGGTGACAGGGAAGCTGCGGTATTTAC
 641 TACCTAGCCCCCATCTTCACTGGTTATTCCACTTATTTAAAATGTCCAGAATAAGCAAATCTCCATATAGAGGAAGTAGA
 721 TTAGTGGTTGCTTCGGGATGGGAGGAATGGGAAGATTGAGGTCTTTCTTTTGCAGTGATAAAAATGTCCTAAAATTGACT
 801 GTAGCGATGGTCACACAACTCTGAATATGCTTAAGACCATTGAATTACACACTTTACGTTGGTGAATTGTATGGTATGTA
 881 AATTATAGTTCAATAACATAGTTACAAAAGATAATCAAAAGCATGAAAGCACTGTTGATGTGGTTTGGATCTGTGTCCTC
 961 ACCGAGTCTCATGTTGAAATGTAAGCCCCCTGGTGGGAGGCGATGGGATTATGGGGCAGAGTCCTCACGAACGGTTTAGC
1041 ACCACCCGCTCAGTGCTGTTCTCCTGATATTGAGTCCTCATCACATCTGGTTGCTTCAAAGTGTGTGGTGCCTCCCCTCT
1121 GTCTCCCTCCTGCTCTGGCCATATAAGATGTGCCTGCTTCTCCTTCGCCTTCTAACATGATTGTAAGTTTCCTGAGGCCT
1201 CCCTAGAAGCAAAAGCTGCTGTGCTTCCTGTACCATCTACAGGACCGTGAGCCAATTAAACCTCTTTTCTTTATAAATTA
1281 AAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' augcgguCAGU-UAUGGAACACu 5'
                 ||||  |:| ||||| 
Target 5' cagaaatGTCATCTGCATTGTGc 3'
 14 - 36 123.00 -10.20
2 
miRNA  3' auGCGGUCAGUUAUGGAACACu 5'
            :|: || |    ||| ||| 
Target 5' aaTGTAAGCC---CCCTGGTGg 3'
 978 - 996 109.00 -7.90
3 
miRNA  3' auGCGGUCAG--UUAU-GGAACAcu 5'
            | ||| ||  |:|: ||| ||  
Target 5' ttCCCCATTCTGAGTGTCCTAGTtg 3'
 499 - 523 106.00 -6.30
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31580775 23 COSMIC
COSN26983195 36 COSMIC
COSN30497200 61 COSMIC
COSN30490941 79 COSMIC
COSN18728107 102 COSMIC
COSN30125713 117 COSMIC
COSN26983194 121 COSMIC
COSN30466593 128 COSMIC
COSN31592354 148 COSMIC
COSN19302408 162 COSMIC
COSN31500126 191 COSMIC
COSN15204175 243 COSMIC
COSN29085861 487 COSMIC
COSN6760514 662 COSMIC
COSN25050800 711 COSMIC
COSN20568496 871 COSMIC
COSN21111975 1144 COSMIC
rs9258 1241 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1175423840 3 dbSNP
rs1426919678 4 dbSNP
rs1325141828 7 dbSNP
rs183328006 8 dbSNP
rs1223360524 13 dbSNP
rs752141107 17 dbSNP
rs372627592 23 dbSNP
rs759186466 24 dbSNP
rs762724082 28 dbSNP
rs1316559202 29 dbSNP
rs766743369 30 dbSNP
rs763267149 33 dbSNP
rs369317000 38 dbSNP
rs1469173790 39 dbSNP
rs1423018188 50 dbSNP
rs990540217 53 dbSNP
rs1310887630 56 dbSNP
rs948695900 58 dbSNP
rs540161078 60 dbSNP
rs928899942 64 dbSNP
rs993261994 66 dbSNP
rs1224534860 67 dbSNP
rs1282209782 74 dbSNP
rs1060827 76 dbSNP
rs1199968541 78 dbSNP
rs1273025546 88 dbSNP
rs1032206932 90 dbSNP
rs1436724058 93 dbSNP
rs757855942 93 dbSNP
rs377416930 102 dbSNP
rs1198476829 103 dbSNP
rs1419403799 105 dbSNP
rs1428860204 106 dbSNP
rs1029490303 107 dbSNP
rs996217446 110 dbSNP
rs13072381 111 dbSNP
rs1420235414 114 dbSNP
rs529360810 116 dbSNP
rs901840280 117 dbSNP
rs568579369 124 dbSNP
rs550167061 125 dbSNP
rs531763821 127 dbSNP
rs999375804 134 dbSNP
rs1266627013 138 dbSNP
rs1006823684 144 dbSNP
rs902359164 148 dbSNP
rs1229073236 151 dbSNP
rs1270438972 154 dbSNP
rs1043600273 155 dbSNP
rs1212337575 159 dbSNP
rs889729148 160 dbSNP
rs1490513640 161 dbSNP
rs1228291538 164 dbSNP
rs1191505736 167 dbSNP
rs946538521 169 dbSNP
rs1260844569 172 dbSNP
rs1409627633 174 dbSNP
rs1215423066 176 dbSNP
rs711994 177 dbSNP
rs998296778 184 dbSNP
rs1230473172 190 dbSNP
rs896893125 192 dbSNP
rs1475113333 195 dbSNP
rs191501363 198 dbSNP
rs560083649 206 dbSNP
rs542009009 207 dbSNP
rs145154287 208 dbSNP
rs1288927325 209 dbSNP
rs574135683 216 dbSNP
rs796607241 217 dbSNP
rs1318538848 220 dbSNP
rs1044572197 222 dbSNP
rs948981091 223 dbSNP
rs917529383 224 dbSNP
rs1316612678 225 dbSNP
rs1399575290 225 dbSNP
rs992835285 226 dbSNP
rs139431464 227 dbSNP
rs75620628 230 dbSNP
rs1464629248 231 dbSNP
rs975204813 233 dbSNP
rs1446696614 237 dbSNP
rs1176667786 238 dbSNP
rs750322378 240 dbSNP
rs147361541 242 dbSNP
rs558563550 243 dbSNP
rs539741753 244 dbSNP
rs186206462 249 dbSNP
rs554033837 252 dbSNP
rs1030025640 253 dbSNP
rs1338304998 254 dbSNP
rs789989 255 dbSNP
rs894943162 256 dbSNP
rs1337510334 259 dbSNP
rs1239484656 260 dbSNP
rs568540278 261 dbSNP
rs1015269484 262 dbSNP
rs142883707 263 dbSNP
rs1183105928 264 dbSNP
rs531879723 264 dbSNP
rs939666887 264 dbSNP
rs1468957795 265 dbSNP
rs908150422 265 dbSNP
rs180920646 266 dbSNP
rs1013535750 267 dbSNP
rs552585973 268 dbSNP
rs770141853 269 dbSNP
rs563162295 271 dbSNP
rs529850244 273 dbSNP
rs560404004 275 dbSNP
rs1225164645 278 dbSNP
rs765454135 278 dbSNP
rs541624396 281 dbSNP
rs947431978 287 dbSNP
rs1254270549 288 dbSNP
rs1481663023 288 dbSNP
rs529860788 288 dbSNP
rs530144322 288 dbSNP
rs910677158 289 dbSNP
rs562369872 290 dbSNP
rs954018460 291 dbSNP
rs922522996 293 dbSNP
rs138674253 294 dbSNP
rs1425554729 295 dbSNP
rs766620723 296 dbSNP
rs188343997 297 dbSNP
rs377741092 298 dbSNP
rs1344655511 299 dbSNP
rs569209980 299 dbSNP
rs1022678326 300 dbSNP
rs1309284582 301 dbSNP
rs540234254 302 dbSNP
rs1251213998 303 dbSNP
rs895990344 304 dbSNP
rs572614522 305 dbSNP
rs557502217 306 dbSNP
rs568652299 307 dbSNP
rs1426403820 308 dbSNP
rs185054051 308 dbSNP
rs556838893 309 dbSNP
rs910603536 310 dbSNP
rs1050963460 311 dbSNP
rs1364401697 312 dbSNP
rs1382844393 313 dbSNP
rs150590337 317 dbSNP
rs750363733 319 dbSNP
rs922416211 320 dbSNP
rs774346137 325 dbSNP
rs1219871938 326 dbSNP
rs939938557 328 dbSNP
rs767537841 329 dbSNP
rs768273465 330 dbSNP
rs1374824288 334 dbSNP
rs1245598211 336 dbSNP
rs1445963957 341 dbSNP
rs1184079195 342 dbSNP
rs912005351 346 dbSNP
rs1403359100 347 dbSNP
rs978117997 349 dbSNP
rs374402469 350 dbSNP
rs952385442 351 dbSNP
rs112222034 352 dbSNP
rs1161260492 354 dbSNP
rs991660270 355 dbSNP
rs1316308428 356 dbSNP
rs1382783302 360 dbSNP
rs764205254 361 dbSNP
rs1033597069 363 dbSNP
rs1164887391 364 dbSNP
rs1437253673 366 dbSNP
rs1036249309 368 dbSNP
rs999071144 369 dbSNP
rs111375997 370 dbSNP
rs903426936 373 dbSNP
rs1458652679 377 dbSNP
rs1021890583 380 dbSNP
rs1011541861 383 dbSNP
rs111743356 384 dbSNP
rs1355846684 387 dbSNP
rs1158679577 388 dbSNP
rs1266233912 391 dbSNP
rs1050480701 393 dbSNP
rs181996572 394 dbSNP
rs534215226 396 dbSNP
rs189242643 397 dbSNP
rs1281814900 398 dbSNP
rs1337471702 399 dbSNP
rs1476592466 403 dbSNP
rs1374453488 407 dbSNP
rs1223631548 412 dbSNP
rs939864917 414 dbSNP
rs548060077 415 dbSNP
rs529971841 416 dbSNP
rs1261907438 419 dbSNP
rs890599878 420 dbSNP
rs1206476330 424 dbSNP
rs984021576 431 dbSNP
rs1233434635 432 dbSNP
rs1480168750 447 dbSNP
rs1304550207 448 dbSNP
rs1410010917 448 dbSNP
rs1481506751 453 dbSNP
rs561203354 453 dbSNP
rs1042451946 461 dbSNP
rs562339301 466 dbSNP
rs530009189 467 dbSNP
rs915319324 478 dbSNP
rs991193501 482 dbSNP
rs532068076 483 dbSNP
rs1470774998 490 dbSNP
rs938010087 493 dbSNP
rs1366080979 498 dbSNP
rs866574295 502 dbSNP
rs1197431685 504 dbSNP
rs1451358384 506 dbSNP
rs1273622596 507 dbSNP
rs1306901411 508 dbSNP
rs1035478292 511 dbSNP
rs1270130027 513 dbSNP
rs759914289 515 dbSNP
rs1224986793 525 dbSNP
rs977549724 532 dbSNP
rs775192072 533 dbSNP
rs1477065870 536 dbSNP
rs981999491 550 dbSNP
rs1420832102 559 dbSNP
rs1021858063 561 dbSNP
rs1011825182 563 dbSNP
rs769549819 565 dbSNP
rs1352697520 566 dbSNP
rs145041200 571 dbSNP
rs546899167 572 dbSNP
rs867889611 573 dbSNP
rs1405985671 574 dbSNP
rs1304792988 576 dbSNP
rs1432271836 577 dbSNP
rs539817792 582 dbSNP
rs1026733246 584 dbSNP
rs1363831537 588 dbSNP
rs572774003 591 dbSNP
rs1298218438 599 dbSNP
rs996945188 600 dbSNP
rs1401912647 603 dbSNP
rs141314169 605 dbSNP
rs747448234 610 dbSNP
rs542528321 613 dbSNP
rs528338314 614 dbSNP
rs556750740 615 dbSNP
rs1448973853 618 dbSNP
rs538452831 625 dbSNP
rs577233898 628 dbSNP
rs185377994 632 dbSNP
rs13322267 640 dbSNP
rs1476942102 641 dbSNP
rs1262771265 647 dbSNP
rs931211287 651 dbSNP
rs1448784465 656 dbSNP
rs1318599547 662 dbSNP
rs1387212196 666 dbSNP
rs1276678477 673 dbSNP
rs915868814 675 dbSNP
rs1317038894 676 dbSNP
rs1345651104 683 dbSNP
rs748921012 689 dbSNP
rs1042565556 706 dbSNP
rs945560313 707 dbSNP
rs1352582162 708 dbSNP
rs781325200 710 dbSNP
rs1216589324 716 dbSNP
rs893904499 717 dbSNP
rs1464473224 720 dbSNP
rs1206975722 722 dbSNP
rs1245491781 723 dbSNP
rs1445702315 724 dbSNP
rs1053864463 734 dbSNP
rs138201969 735 dbSNP
rs1432543249 736 dbSNP
rs1158762864 738 dbSNP
rs1338177447 739 dbSNP
rs548218951 747 dbSNP
rs536095426 749 dbSNP
rs755909373 751 dbSNP
rs1406191683 752 dbSNP
rs1395321948 759 dbSNP
rs938367190 760 dbSNP
rs949249521 762 dbSNP
rs1407513020 765 dbSNP
rs369105069 766 dbSNP
rs568819276 767 dbSNP
rs1239565785 771 dbSNP
rs1178973424 774 dbSNP
rs550325489 776 dbSNP
rs532356694 778 dbSNP
rs1328812316 780 dbSNP
rs745641986 786 dbSNP
rs781348181 797 dbSNP
rs796070701 802 dbSNP
rs1464372175 805 dbSNP
rs181524782 806 dbSNP
rs145662661 810 dbSNP
rs1254744828 811 dbSNP
rs967150574 812 dbSNP
rs369283039 822 dbSNP
rs1410754522 827 dbSNP
rs1471372936 828 dbSNP
rs964051647 834 dbSNP
rs1429334854 835 dbSNP
rs1465131007 836 dbSNP
rs528212405 837 dbSNP
rs1398628444 840 dbSNP
rs1391745333 841 dbSNP
rs1007839646 844 dbSNP
rs1348397103 845 dbSNP
rs954995817 850 dbSNP
rs879239565 852 dbSNP
rs990357893 857 dbSNP
rs189878543 858 dbSNP
rs1029256168 860 dbSNP
rs1254764894 862 dbSNP
rs1342158157 864 dbSNP
rs1206519388 872 dbSNP
rs1010180480 875 dbSNP
rs1482299147 879 dbSNP
rs540954236 882 dbSNP
rs1201079035 897 dbSNP
rs997887494 898 dbSNP
rs1432063286 899 dbSNP
rs148929244 901 dbSNP
rs1462370271 906 dbSNP
rs893947678 909 dbSNP
rs1054300926 910 dbSNP
rs1196711545 931 dbSNP
rs789990 934 dbSNP
rs386669928 937 dbSNP
rs905202273 940 dbSNP
rs1046468481 944 dbSNP
rs949363736 950 dbSNP
rs1014932404 963 dbSNP
rs563193356 964 dbSNP
rs1340454813 965 dbSNP
rs1283048506 967 dbSNP
rs1448152367 968 dbSNP
rs887886579 973 dbSNP
rs1048211939 975 dbSNP
rs544453370 976 dbSNP
rs865867812 980 dbSNP
rs1263167652 982 dbSNP
rs1339232180 985 dbSNP
rs1187825562 989 dbSNP
rs1388290681 992 dbSNP
rs1446220799 994 dbSNP
rs1164039349 995 dbSNP
rs577348067 997 dbSNP
rs1457536537 1000 dbSNP
rs1400016238 1001 dbSNP
rs894347174 1002 dbSNP
rs1387174303 1005 dbSNP
rs1435975927 1006 dbSNP
rs1297474796 1014 dbSNP
rs558921377 1016 dbSNP
rs1493 1029 dbSNP
rs938322411 1030 dbSNP
rs573260170 1031 dbSNP
rs963794692 1032 dbSNP
rs1218858005 1033 dbSNP
rs1262174700 1035 dbSNP
rs1464929786 1041 dbSNP
rs1041429722 1043 dbSNP
rs759876641 1047 dbSNP
rs914360199 1048 dbSNP
rs776982376 1049 dbSNP
rs1233175476 1054 dbSNP
rs554502677 1062 dbSNP
rs1319502509 1064 dbSNP
rs1414520931 1065 dbSNP
rs1457835807 1066 dbSNP
rs1288675327 1069 dbSNP
rs184556210 1070 dbSNP
rs1386548238 1076 dbSNP
rs922155895 1076 dbSNP
rs976376107 1077 dbSNP
rs1491 1083 dbSNP
rs1002776658 1086 dbSNP
rs1308687500 1087 dbSNP
rs1329500236 1094 dbSNP
rs1014858709 1095 dbSNP
rs1004878702 1098 dbSNP
rs1238541074 1102 dbSNP
rs761193117 1110 dbSNP
rs1027701538 1116 dbSNP
rs15304 1121 dbSNP
rs1236887910 1124 dbSNP
rs894325642 1141 dbSNP
rs1482138188 1149 dbSNP
rs538588735 1153 dbSNP
rs1254232095 1156 dbSNP
rs1473001587 1165 dbSNP
rs571409122 1166 dbSNP
rs768087416 1167 dbSNP
rs1425595327 1177 dbSNP
rs1047424191 1178 dbSNP
rs907159984 1181 dbSNP
rs1041398437 1182 dbSNP
rs1310178659 1183 dbSNP
rs919827323 1185 dbSNP
rs945704254 1196 dbSNP
rs1286096584 1198 dbSNP
rs191770485 1199 dbSNP
rs1054225749 1203 dbSNP
rs371981876 1206 dbSNP
rs1487365486 1212 dbSNP
rs1310433856 1219 dbSNP
rs567381537 1221 dbSNP
rs1206539456 1227 dbSNP
rs922110398 1228 dbSNP
rs1245978808 1232 dbSNP
rs1482616020 1235 dbSNP
rs9258 1241 dbSNP
rs1490743340 1243 dbSNP
rs767514803 1246 dbSNP
rs145844217 1247 dbSNP
rs149855601 1249 dbSNP
rs544874705 1255 dbSNP
rs141028878 1262 dbSNP
rs565472709 1267 dbSNP
rs1027670593 1271 dbSNP
rs1305768736 1274 dbSNP
rs1332534495 1276 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 55341.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM1065667. RNA binding protein: AGO1. Condition:4-thiouridine ...

- Memczak S; Jens M; Elefsinioti A; Torti F; et al., 2013, Nature.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' auGCGGUCAGUUAUGGAACacu 5'
            ||||   |   ||| ||   
Target 5' ucCGCC---C---ACCCUGgcc 3'
 		2 - 17
Article - Memczak S; Jens M; Elefsinioti A; Torti F; et al.
- Nature, 2013
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.
LinkOut: [PMID: 23446348]
CLIP-seq Support 1 for dataset GSM1065667
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / 4-thiouridine, ML_MM_6
Location of target site ENST00000265245.5 | 3UTR | AUCCGCCCACCCUGGCCUCCCAAAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
83 hsa-miR-4457 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT098032 SOBP sine oculis binding protein homolog 2 2
MIRT202580 PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 2 6
MIRT247137 WEE1 WEE1 G2 checkpoint kinase 2 4
MIRT349266 PTBP1 polypyrimidine tract binding protein 1 2 2
MIRT363756 EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 2 2
MIRT443586 FAM84B family with sequence similarity 84 member B 2 2
MIRT452333 EIF5AL1 eukaryotic translation initiation factor 5A-like 1 2 2
MIRT453864 ZBTB40 zinc finger and BTB domain containing 40 2 4
MIRT471486 PDE4D phosphodiesterase 4D 2 4
MIRT476290 GMFB glia maturation factor beta 2 8
MIRT479897 CCDC117 coiled-coil domain containing 117 2 4
MIRT484251 ANK1 ankyrin 1 2 2
MIRT491473 TMEM214 transmembrane protein 214 2 2
MIRT493804 GAN gigaxonin 2 6
MIRT499252 VAV3 vav guanine nucleotide exchange factor 3 2 4
MIRT502271 HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 2 4
MIRT504651 RPL9 ribosomal protein L9 2 6
MIRT505211 UBN2 ubinuclein 2 2 8
MIRT508952 SNRPB small nuclear ribonucleoprotein polypeptides B and B1 2 4
MIRT512691 POP1 POP1 homolog, ribonuclease P/MRP subunit 2 2
MIRT513320 SCUBE3 signal peptide, CUB domain and EGF like domain containing 3 2 2
MIRT513870 HOXA5 homeobox A5 2 2
MIRT517342 ZNF529 zinc finger protein 529 2 4
MIRT518947 LSG1 large 60S subunit nuclear export GTPase 1 2 2
MIRT520867 SUGT1 SGT1 homolog, MIS12 kinetochore complex assembly cochaperone 2 2
MIRT528325 GIGYF2 GRB10 interacting GYF protein 2 2 2
MIRT531990 SLCO1B3 solute carrier organic anion transporter family member 1B3 2 2
MIRT533298 USP46 ubiquitin specific peptidase 46 2 2
MIRT545257 TRIM36 tripartite motif containing 36 2 4
MIRT547038 POGZ pogo transposable element derived with ZNF domain 2 2
MIRT556103 MOAP1 modulator of apoptosis 1 2 2
MIRT558321 DR1 down-regulator of transcription 1 2 2
MIRT558521 CSRNP3 cysteine and serine rich nuclear protein 3 2 2
MIRT560906 TMED10 transmembrane p24 trafficking protein 10 2 2
MIRT568448 ARPP19 cAMP regulated phosphoprotein 19 2 2
MIRT570586 OTUD7B OTU deubiquitinase 7B 2 2
MIRT572799 SIGLEC14 sialic acid binding Ig like lectin 14 2 2
MIRT573863 C9orf78 chromosome 9 open reading frame 78 2 2
MIRT575058 P2ry1 purinergic receptor P2Y, G-protein coupled 1 2 5
MIRT609931 SLC38A1 solute carrier family 38 member 1 2 4
MIRT610836 ZNF585A zinc finger protein 585A 2 4
MIRT611474 P2RY1 purinergic receptor P2Y1 2 7
MIRT613569 YY2 YY2 transcription factor 2 2
MIRT618626 GREB1 growth regulation by estrogen in breast cancer 1 2 2
MIRT620606 SAP30 Sin3A associated protein 30 2 2
MIRT621017 CLSTN3 calsyntenin 3 2 4
MIRT635314 FAM179A TOG array regulator of axonemal microtubules 2 2 2
MIRT635919 GLTSCR2 NOP53 ribosome biogenesis factor 2 2
MIRT640598 TM9SF4 transmembrane 9 superfamily member 4 2 2
MIRT641784 YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta 2 4
MIRT644067 IQCE IQ motif containing E 2 2
MIRT648288 TRAPPC2L trafficking protein particle complex 2 like 2 2
MIRT658085 FOXR2 forkhead box R2 2 2
MIRT659077 DEPTOR DEP domain containing MTOR interacting protein 2 2
MIRT665307 ZBTB37 zinc finger and BTB domain containing 37 2 2
MIRT665975 SYTL4 synaptotagmin like 4 2 2
MIRT666302 SLC25A25 solute carrier family 25 member 25 2 2
MIRT674906 RASSF9 Ras association domain family member 9 2 2
MIRT680086 THAP1 THAP domain containing 1 2 2
MIRT681488 DIP2A disco interacting protein 2 homolog A 2 2
MIRT691244 DFNB59 pejvakin 2 2
MIRT692362 AGTRAP angiotensin II receptor associated protein 2 2
MIRT693035 MB21D1 Mab-21 domain containing 1 2 2
MIRT693837 STAT5A signal transducer and activator of transcription 5A 2 2
MIRT694479 LRTOMT leucine rich transmembrane and O-methyltransferase domain containing 2 2
MIRT696070 ZNF264 zinc finger protein 264 2 2
MIRT696578 TTC21B tetratricopeptide repeat domain 21B 2 2
MIRT696760 MTFMT mitochondrial methionyl-tRNA formyltransferase 2 2
MIRT697307 ZNF652 zinc finger protein 652 2 2
MIRT700152 RNF115 ring finger protein 115 2 2
MIRT701056 PARP2 poly(ADP-ribose) polymerase 2 2 2
MIRT701198 OTUD3 OTU deubiquitinase 3 2 2
MIRT701335 NSD1 nuclear receptor binding SET domain protein 1 2 2
MIRT702656 ITGA3 integrin subunit alpha 3 2 2
MIRT703618 FBXO45 F-box protein 45 2 2
MIRT704673 CHTOP chromatin target of PRMT1 2 2
MIRT708894 ZNF780A zinc finger protein 780A 2 2
MIRT711620 DGKH diacylglycerol kinase eta 2 2
MIRT713745 TMEM81 transmembrane protein 81 2 2
MIRT719712 CD101 CD101 molecule 2 2
MIRT720294 DLGAP3 DLG associated protein 3 2 2
MIRT722606 CCDC152 coiled-coil domain containing 152 2 2
MIRT724566 ACSBG1 acyl-CoA synthetase bubblegum family member 1 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4457 Dabrafenib 44462760 NSC764134 approved sensitive cell line (A375)
hsa-miR-4457 Gefitinib 123631 NSC715055 approved sensitive cell line (PC9)
hsa-miR-4457 Osimertinib 71496458 NSC779217 approved sensitive cell line (PC9)
hsa-miR-4457 Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)

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