pre-miRNA Information
pre-miRNA hsa-mir-2115   
Genomic Coordinates chr3: 48316360 - 48316459
Description Homo sapiens miR-2115 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-2115-3p
Sequence 58| CAUCAGAAUUCAUGGAGGCUAG |79
Evidence Experimental
Experiments 454
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN31490809 22 COSMIC
COSN31579735 22 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs543123304 18 dbSNP
rs1450988157 21 dbSNP
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol KYNU   
Synonyms KYNUU
Description kynureninase
Transcript NM_001032998   
Other Transcripts NM_003937   
Expression
Putative miRNA Targets on KYNU
3'UTR of KYNU
(miRNA target sites are highlighted)
>KYNU|NM_001032998|3'UTR
   1 GAATGGAATGCAACAGATTTGGACAAGTCAAGGACAAGAGCTTTAGAGAGACCAAAGAGTTTTTCACTGTTAAAGTGTCC
  81 AGTATGTAGCCGAGAACCATATGGAGAACATCAAATACAGTGGAACAAATGTAACTGCTATTGATGTCACACTTTGTGAA
 161 GTAGTCTTTGTTGCTTAAAAAGGGTGACATCTAGTGGCTAAACATGTTATTTCAAATAAATAATATCGAAATAAAAAAAA
 241 AAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' gaucggaggUAC-UU----AAGACUAc 5'
                   ||| ||    | :|||| 
Target 5' gtggaacaaATGTAACTGCTATTGATg 3'
120 - 146 95.00 -5.60
2
miRNA  3' gaucggagGUAC--UUAAGACUAc 5'
                  ||||  | |||  || 
Target 5' tggctaaaCATGTTATTTCAAATa 3'
195 - 218 88.00 -5.23
3
miRNA  3' gaucgGAGGUACUU----A-AGACUAc 5'
               ||:::||||    | |:|| | 
Target 5' tcacaCTTTGTGAAGTAGTCTTTGTTg 3'
147 - 173 79.00 -7.73
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN18437477 5 COSMIC
COSN31555403 7 COSMIC
COSN31561223 17 COSMIC
COSN28797435 60 COSMIC
COSN26435741 121 COSMIC
COSN30727622 157 COSMIC
COSN30664516 190 COSMIC
COSN16508147 323 COSMIC
COSN17821910 456 COSMIC
COSN9065397 519 COSMIC
COSN15661911 530 COSMIC
COSN31624231 625 COSMIC
COSN15202193 632 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs777811253 3 dbSNP
rs1263795421 9 dbSNP
rs78123209 10 dbSNP
rs887864028 12 dbSNP
rs756655624 20 dbSNP
rs200138991 24 dbSNP
rs371112079 25 dbSNP
rs1255590916 32 dbSNP
rs745497859 35 dbSNP
rs1387845372 37 dbSNP
rs529003443 39 dbSNP
rs772398719 40 dbSNP
rs1398739136 42 dbSNP
rs775802924 42 dbSNP
rs962365050 43 dbSNP
rs1220594839 45 dbSNP
rs1324573310 46 dbSNP
rs200744584 48 dbSNP
rs1317474001 50 dbSNP
rs769169725 51 dbSNP
rs777061994 52 dbSNP
rs1469427169 58 dbSNP
rs10496935 60 dbSNP
rs1361249391 62 dbSNP
rs979492324 70 dbSNP
rs1449274437 73 dbSNP
rs925009345 75 dbSNP
rs116077282 76 dbSNP
rs1487242170 80 dbSNP
rs1221025074 89 dbSNP
rs1278209699 111 dbSNP
rs1241480933 124 dbSNP
rs1322220882 131 dbSNP
rs780393084 132 dbSNP
rs532936525 135 dbSNP
rs987895115 138 dbSNP
rs775634073 149 dbSNP
rs763176746 157 dbSNP
rs551745107 161 dbSNP
rs1214761582 164 dbSNP
rs914415048 168 dbSNP
rs1486775619 175 dbSNP
rs569958138 181 dbSNP
rs1275974248 186 dbSNP
rs1439035162 188 dbSNP
rs1348568215 190 dbSNP
rs1323104072 196 dbSNP
rs1424427208 198 dbSNP
rs368518066 201 dbSNP
rs1402756003 207 dbSNP
rs572254756 208 dbSNP
rs1040618882 209 dbSNP
rs977588529 222 dbSNP
rs932274762 225 dbSNP
rs1174516123 226 dbSNP
rs1049525379 228 dbSNP
rs143590880 241 dbSNP
rs943711008 242 dbSNP
rs1318011721 246 dbSNP
rs747575493 251 dbSNP
rs1259594388 277 dbSNP
rs1343815866 281 dbSNP
rs1196144239 283 dbSNP
rs1036424225 292 dbSNP
rs1402325707 294 dbSNP
rs10496936 316 dbSNP
rs1344304064 317 dbSNP
rs1221198122 324 dbSNP
rs1365898647 326 dbSNP
rs148042799 328 dbSNP
rs781173296 335 dbSNP
rs932273353 342 dbSNP
rs1448026945 346 dbSNP
rs184502820 349 dbSNP
rs748294425 350 dbSNP
rs537529269 357 dbSNP
rs1329582751 364 dbSNP
rs887970766 374 dbSNP
rs1465160849 381 dbSNP
rs1006275425 404 dbSNP
rs1015440291 409 dbSNP
rs1345227474 413 dbSNP
rs1050950 415 dbSNP
rs1281805735 417 dbSNP
rs571817467 420 dbSNP
rs1035727855 423 dbSNP
rs1176465270 424 dbSNP
rs958593073 425 dbSNP
rs991434302 429 dbSNP
rs113803554 432 dbSNP
rs987863777 433 dbSNP
rs538856956 441 dbSNP
rs112859543 445 dbSNP
rs575508998 455 dbSNP
rs1490197109 459 dbSNP
rs1241258111 464 dbSNP
rs968976546 467 dbSNP
rs773585902 471 dbSNP
rs976638671 486 dbSNP
rs1478444209 487 dbSNP
rs922162790 490 dbSNP
rs924365376 493 dbSNP
rs1406232951 510 dbSNP
rs1379958680 514 dbSNP
rs10496937 516 dbSNP
rs1445954524 520 dbSNP
rs976387395 528 dbSNP
rs920950965 529 dbSNP
rs1050951 530 dbSNP
rs1036351958 531 dbSNP
rs1156432244 536 dbSNP
rs189483028 537 dbSNP
rs896557971 546 dbSNP
rs1013665968 548 dbSNP
rs1331187152 551 dbSNP
rs1481998446 559 dbSNP
rs1257421693 564 dbSNP
rs1051130574 569 dbSNP
rs1489458185 570 dbSNP
rs1284385610 584 dbSNP
rs541123479 586 dbSNP
rs942194243 593 dbSNP
rs750933914 596 dbSNP
rs759023418 600 dbSNP
rs775409791 601 dbSNP
rs1215780895 605 dbSNP
rs1354975108 622 dbSNP
rs1312166277 626 dbSNP
rs1036413464 643 dbSNP
rs956331098 646 dbSNP
rs145080321 647 dbSNP
rs1452790544 663 dbSNP
rs376147661 665 dbSNP
rs1421542777 666 dbSNP
rs565456213 672 dbSNP
rs1195005799 673 dbSNP
rs1479061233 675 dbSNP
rs1261697507 676 dbSNP
rs1002996991 678 dbSNP
rs1204853697 679 dbSNP
rs1489043992 682 dbSNP
rs1357124553 697 dbSNP
rs1267449676 707 dbSNP
rs965122140 721 dbSNP
rs1334223486 723 dbSNP
rs1220572522 725 dbSNP
rs181100555 731 dbSNP
rs894493417 735 dbSNP
rs563603754 740 dbSNP
rs1236631468 742 dbSNP
rs75299935 743 dbSNP
rs1179599857 746 dbSNP
rs1393306023 748 dbSNP
rs1170728885 751 dbSNP
rs1385022119 754 dbSNP
rs879108153 755 dbSNP
rs940971336 756 dbSNP
rs1269975230 758 dbSNP
rs549266922 766 dbSNP
rs1036320886 767 dbSNP
rs185783926 783 dbSNP
rs1258951225 787 dbSNP
rs1390812221 788 dbSNP
rs528431102 791 dbSNP
rs1316208328 793 dbSNP
rs965078427 794 dbSNP
rs976498439 799 dbSNP
rs1045155462 802 dbSNP
rs904999399 803 dbSNP
rs190499171 806 dbSNP
rs1331631316 811 dbSNP
rs1466726788 815 dbSNP
rs1393741881 816 dbSNP
rs1167820022 824 dbSNP
rs1466960594 825 dbSNP
rs1447084845 832 dbSNP
rs953731099 836 dbSNP
rs1314031930 842 dbSNP
rs1454115241 847 dbSNP
rs1180823145 859 dbSNP
rs1054056298 860 dbSNP
rs1249973501 871 dbSNP
rs892368867 872 dbSNP
rs1009525916 874 dbSNP
rs1246892993 881 dbSNP
rs986358552 886 dbSNP
rs1257695219 891 dbSNP
rs1231733865 896 dbSNP
rs1284767023 903 dbSNP
rs909461973 913 dbSNP
rs1309489343 917 dbSNP
rs1448596053 918 dbSNP
rs764059589 921 dbSNP
rs776390062 933 dbSNP
rs1327551253 937 dbSNP
rs1396108725 938 dbSNP
rs1404903560 942 dbSNP
rs1195338927 944 dbSNP
rs1256263351 946 dbSNP
rs571633459 962 dbSNP
rs1434484548 969 dbSNP
rs900842833 973 dbSNP
rs1160661094 974 dbSNP
rs1036935624 978 dbSNP
rs919455591 996 dbSNP
rs1468756944 998 dbSNP
rs181704393 1005 dbSNP
rs761408328 1025 dbSNP
rs764815031 1027 dbSNP
rs771303760 1033 dbSNP
rs1444214137 1036 dbSNP
rs952600594 1041 dbSNP
rs1208685372 1044 dbSNP
rs894442741 1050 dbSNP
rs984960488 1052 dbSNP
rs1286404589 1056 dbSNP
rs1013342797 1058 dbSNP
rs1016428308 1067 dbSNP
rs550781722 1069 dbSNP
rs1278601050 1074 dbSNP
rs962263517 1077 dbSNP
rs1043097748 1084 dbSNP
rs1475390221 1085 dbSNP
rs569071643 1088 dbSNP
rs1167852195 1089 dbSNP
rs1401858897 1090 dbSNP
rs1465755132 1091 dbSNP
rs1335750143 1093 dbSNP
rs972299624 1094 dbSNP
rs1403614258 1095 dbSNP
rs138841531 1098 dbSNP
rs551044637 1117 dbSNP
rs1414772390 1122 dbSNP
rs1361764853 1126 dbSNP
rs949430477 1130 dbSNP
rs1300394604 1131 dbSNP
rs1399327084 1134 dbSNP
rs141966642 1142 dbSNP
rs1031450928 1143 dbSNP
rs965195468 1151 dbSNP
rs997865961 1160 dbSNP
rs936773914 1166 dbSNP
rs1028030565 1170 dbSNP
rs1474816560 1175 dbSNP
rs1263814769 1176 dbSNP
rs953702934 1182 dbSNP
rs1012875 1189 dbSNP
rs1016638739 1192 dbSNP
rs963946786 1193 dbSNP
rs1357828193 1194 dbSNP
rs1290855259 1195 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293
Disease 8942.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "HITS-CLIP data was present in GSM714642. RNA binding protein: AGO2. Condition:completeT1 "PAR-CLIP data was present in GSM714644. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 8942.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM1065667. RNA binding protein: AGO1. Condition:4-thiouridine ...

- Memczak S; Jens M; Elefsinioti A; Torti F; et al., 2013, Nature.

Article - Memczak S; Jens M; Elefsinioti A; Torti F; et al.
- Nature, 2013
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.
LinkOut: [PMID: 23446348]
Experimental Support 3 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084045. RNA binding protein: AGO2. Condition:CLIP_arsenite_rep3 HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb HITS-CLIP data was present in GSM1084078. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep2_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM714642
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repA
Location of target site ENST00000264170.4 | 3UTR | UGAUAUAUAUAUAUAUAUAUA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084045
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_arsenite_rep3
Location of target site ENST00000264170.4 | 3UTR | UGAUAUAUAUAUAUAUAUAUAUAUAUAUAUAUAUAU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000264170.4 | 3UTR | GUCUGAUAUAUAUAUAUAUAUAU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM1084078
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_nohippuristanol_rep2_AbnovaAb
Location of target site ENST00000264170.4 | 3UTR | GUCUGAUAUAUAUAUAUAUAUAU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM714644
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repA
Location of target site ENST00000264170.4 | 3UTR | UGAUAUAUAUAUAUAUAUAUAUAUAUAUAUAUAUAUAUAUAUAUAUAUAUGUGUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM1065667
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / 4-thiouridine, ML_MM_6
Location of target site ENST00000264170.4 | 3UTR | UGAUAUAUAUAUAUAUAUAUAUAUAUAUAU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
BRCA 0.498 0 0.384 0.02 31 Click to see details
BLCA 0.831 0.02 0.886 0.01 6 Click to see details
HNSC -0.468 0.05 -0.332 0.12 14 Click to see details
LUSC -0.309 0.13 -0.414 0.06 15 Click to see details
UCEC -0.773 0.22 -0.500 0.33 3 Click to see details
STAD 0.609 0.29 0.500 0.33 3 Click to see details
LIHC 0.283 0.36 0.400 0.3 4 Click to see details
LIHC 0.283 0.36 0.400 0.3 4 Click to see details
LIHC 0.283 0.36 0.400 0.3 4 Click to see details
LIHC 0.283 0.36 0.400 0.3 4 Click to see details
LIHC 0.283 0.36 0.400 0.3 4 Click to see details
LIHC 0.283 0.36 0.400 0.3 4 Click to see details
LIHC 0.283 0.36 0.400 0.3 4 Click to see details
80 hsa-miR-2115-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT057089 DDIT4 DNA damage inducible transcript 4 2 2
MIRT071216 FCF1 FCF1, rRNA-processing protein 2 2
MIRT226901 RAD23B RAD23 homolog B, nucleotide excision repair protein 2 2
MIRT235961 BACH1 BTB domain and CNC homolog 1 2 2
MIRT294569 ZNF460 zinc finger protein 460 2 4
MIRT321046 RAC1 Rac family small GTPase 1 2 4
MIRT359666 NUS1 NUS1 dehydrodolichyl diphosphate synthase subunit 2 8
MIRT366451 KLHL15 kelch like family member 15 2 2
MIRT405375 ZBTB18 zinc finger and BTB domain containing 18 2 2
MIRT441794 TCEAL5 transcription elongation factor A like 5 2 2
MIRT443295 TCEAL3 transcription elongation factor A like 3 2 2
MIRT455275 DDX39B DExD-box helicase 39B 2 2
MIRT458523 C5orf22 chromosome 5 open reading frame 22 2 2
MIRT464960 TWIST1 twist family bHLH transcription factor 1 2 2
MIRT466848 STX6 syntaxin 6 2 2
MIRT469252 RHOB ras homolog family member B 2 2
MIRT469825 RAB14 RAB14, member RAS oncogene family 2 4
MIRT470047 PTGFRN prostaglandin F2 receptor inhibitor 2 2
MIRT471420 PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 2 2
MIRT472024 NPM1 nucleophosmin 1 2 2
MIRT484156 CENPN centromere protein N 2 2
MIRT485490 HMGN2 high mobility group nucleosomal binding domain 2 2 2
MIRT490462 PROSER2 proline and serine rich 2 2 2
MIRT493069 MTCH1 mitochondrial carrier 1 2 2
MIRT493573 HSP90AA1 heat shock protein 90 alpha family class A member 1 2 8
MIRT494919 NDUFC2-KCTD14 NDUFC2-KCTD14 readthrough 2 2
MIRT500439 ZMAT3 zinc finger matrin-type 3 2 2
MIRT500931 SRPR SRP receptor alpha subunit 2 4
MIRT501551 POC1B-GALNT4 POC1B-GALNT4 readthrough 2 2
MIRT501809 NEURL1B neuralized E3 ubiquitin protein ligase 1B 2 2
MIRT502415 GALNT4 polypeptide N-acetylgalactosaminyltransferase 4 2 2
MIRT506504 MSANTD4 Myb/SANT DNA binding domain containing 4 with coiled-coils 2 2
MIRT507861 CCNE2 cyclin E2 2 2
MIRT510511 YOD1 YOD1 deubiquitinase 2 6
MIRT516073 RAB42 RAB42, member RAS oncogene family 2 2
MIRT519030 KYNU kynureninase 2 6
MIRT521762 PPIL1 peptidylprolyl isomerase like 1 2 4
MIRT522898 KCNJ3 potassium voltage-gated channel subfamily J member 3 2 4
MIRT527370 MGARP mitochondria localized glutamic acid rich protein 2 2
MIRT530691 C8orf46 chromosome 8 open reading frame 46 2 2
MIRT530867 TRUB1 TruB pseudouridine synthase family member 1 2 2
MIRT531832 MTPAP mitochondrial poly(A) polymerase 2 4
MIRT533035 ZBTB5 zinc finger and BTB domain containing 5 2 2
MIRT533165 WIPF2 WAS/WASL interacting protein family member 2 2 2
MIRT533464 TRIM71 tripartite motif containing 71 2 2
MIRT534331 SHCBP1 SHC binding and spindle associated 1 2 2
MIRT539372 ADSS adenylosuccinate synthase 2 6
MIRT545951 ZBTB10 zinc finger and BTB domain containing 10 2 2
MIRT553283 TSR1 TSR1, ribosome maturation factor 2 2
MIRT553532 TMEM185B transmembrane protein 185B 2 4
MIRT556480 LIPA lipase A, lysosomal acid type 2 2
MIRT556975 HSPA4L heat shock protein family A (Hsp70) member 4 like 2 2
MIRT557697 GATA6 GATA binding protein 6 2 2
MIRT558901 CCDC58 coiled-coil domain containing 58 2 2
MIRT559224 BLMH bleomycin hydrolase 2 2
MIRT559827 SLPI secretory leukocyte peptidase inhibitor 2 2
MIRT563435 SLC3A2 solute carrier family 3 member 2 2 2
MIRT569270 PCDH11X protocadherin 11 X-linked 2 2
MIRT571386 JKAMP JNK1/MAPK8-associated membrane protein 2 2
MIRT572567 AFF1 AF4/FMR2 family member 1 2 2
MIRT610400 AR androgen receptor 2 2
MIRT611058 ZNF621 zinc finger protein 621 2 2
MIRT635118 TMEM233 transmembrane protein 233 2 2
MIRT641617 DEFB118 defensin beta 118 2 2
MIRT642146 CHORDC1 cysteine and histidine rich domain containing 1 2 2
MIRT647295 C8orf33 chromosome 8 open reading frame 33 2 2
MIRT648155 MPLKIP M-phase specific PLK1 interacting protein 2 2
MIRT652780 TENM3 teneurin transmembrane protein 3 2 2
MIRT657356 HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 2 2
MIRT658718 ELN elastin 2 2
MIRT662441 RALGAPA1 Ral GTPase activating protein catalytic alpha subunit 1 2 2
MIRT665302 ZBTB38 zinc finger and BTB domain containing 38 2 2
MIRT699898 RUNX1 runt related transcription factor 1 2 2
MIRT700921 PDS5A PDS5 cohesin associated factor A 2 2
MIRT700992 PDE3A phosphodiesterase 3A 2 2
MIRT707397 DCAF4L1 DDB1 and CUL4 associated factor 4 like 1 2 2
MIRT711895 INSIG2 insulin induced gene 2 2 2
MIRT712072 XRCC5 X-ray repair cross complementing 5 2 2
MIRT716121 PTPLAD2 3-hydroxyacyl-CoA dehydratase 4 1 1
MIRT724470 SMAD2 SMAD family member 2 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-2115 Docetaxel+Cisplatin+5-Fluorouracil sensitive tissue (hypopharyngeal squamous cell carcinoma)
hsa-mir-2115 Decitabine 451668 approved sensitive tissue (esopheageal cancer)
hsa-miR-2115-3p Imatinib 5291 NSC743414 approved resistant High Chronic Myelogenous Leukemia cell line (K562)
hsa-miR-2115-3p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-2115-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-2115-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-miR-2115-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-2115-3p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-miR-2115-3p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)

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