pre-miRNA Information | |
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pre-miRNA | hsa-mir-1208 |
Genomic Coordinates | chr8: 128150116 - 128150188 |
Synonyms | MIRN1208, hsa-mir-1208, MIR1208 |
Description | Homo sapiens miR-1208 stem-loop |
Comment | None |
RNA Secondary Structure |
Mature miRNA Information | ||||||||||||||||||||||||||||
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Mature miRNA | hsa-miR-1208 | |||||||||||||||||||||||||||
Sequence | 12| UCACUGUUCAGACAGGCGGA |31 | |||||||||||||||||||||||||||
Evidence | Experimental | |||||||||||||||||||||||||||
Experiments | Northern | |||||||||||||||||||||||||||
SNPs in miRNA |
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Putative Targets |
miRNA Expression profile | |
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Human miRNA Tissue Atlas | |
Circulating MicroRNA Expression Profiling |
Gene Information | |||||||||||||||||||||
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Gene Symbol | IVD | ||||||||||||||||||||
Synonyms | ACAD2 | ||||||||||||||||||||
Description | isovaleryl-CoA dehydrogenase | ||||||||||||||||||||
Transcript | NM_002225 | ||||||||||||||||||||
Other Transcripts | NM_001159508 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on IVD | |||||||||||||||||||||
3'UTR of IVD (miRNA target sites are highlighted) |
>IVD|NM_002225|3'UTR 1 TCCTGAGACCCTTCGCCCCCTTTTCCTGCACCTAGTGGCCTTTCTTGGGAAGTAGAGATGTGGCGGCTTTCCCACCCTGC 81 CCACAGCAGGCCCTCCTGCCCAGCTGCTCTTGTCAGCCCTCTGGCCTCTGGATGAGGTTGAGTTCTCCACAACAGCTCCC 161 AAGCATCATGGGCCTCGCAGCCGGGCCTGTGCCACGGCTAGTGTTGTGTGATTTAAAATGGACTCAGCAGGAAGCATATT 241 GTCTGGGGATTGTTGGGACAGGTTTTGGTGACTCTGTGCCCTTGCTCTCTAACTTCTGAGCCCACCTCCCAGGGTAGGCA 321 CCTGGGGGCATGCAGGTGCCCACCTCCCAGGGTAGGCACCTGGGGGCATGCAGGTACCCACCTCTTTCTCTTGGGTGAGG 401 CTCTGGCAAGGAGATCTCTCTGCTCAAGCACAGCAGAATCATGGCCCCTCTCCATGAATTGGAACTTGGTACAGGTTAAG 481 TATCCCTAATCCTGAAATCTGAAACACTTGTGGTTCCAAGCATTTTGGATAAGGCAAATTCAACTTTCAGTCTCTTTTCT 561 GGGGGAAAAAAATAATAAACCTAGCCTAGCCAGGCGTGGTGGCTCATGCTTGTAATCCCAGCACTTCAGGAGGCTGAGAT 641 GGGTGGATCACCTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGTGGAAACCTCGCCTCAACTAAAAATAGAAAAA 721 AATTAGTTGGGCATGGTGGTGGGCACCTGTAATCCCAGCTACTTCAGGAGGCTGAGGCAGGAGAATTACTTGAACCCAGG 801 AGGCGGACGTTGCAGTGAGCCGAGCTTGTGCCATTGCACTCCAGCCTGGGCGACAAGAGCAAAACTCTTCAAAAAACAAA 881 ACAAAACAAAAAAACCCTGGCCCTTGTTTCTTCCAGTTTCTAGAGGTATCAGCTCCTAGCAGCTTATGAACACATATGCT 961 TGCTTGGCCAGGCAAGGTGGTGTGTGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCAGGTGGATCACTTGCAGTCAGG 1041 AGTTCAAGACCAGCCTGTCCAACGTGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCCAGGGGTGGTGGTGCAC 1121 GTCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCACTTGAACCCGGGAGGTGGAGGTTGCAATGAGCCAATA 1201 TGACACCGCTGCAGTCCAGCCTGGGCCATAGAGTGAGACTCTGTCTCAAAAAAGGAAAGAAAAATAGGCTGGGCACAGTG 1281 ACTCATGCCTGTAATCCCAACACTTTGGGAGGCCGAGGCAGGTGGATCACGAGGTCAGGAGTTCAAGACCAGCCTGGCCA 1361 AGATGGTAAAACCTCGTCTCTACTAAAAATACAAAAATTAGCCAGGTGTGGTGGCAGGCTCCTGTAATCCCAGCTACTCA 1441 GGAGGCTGAGGCAGAGAATTGCTTGAACCCGGGAGGCAGAGTTTGCAGTGAGCCAAGATCACACCACTGCACTCCAGCTT 1521 GGACGACAGAGCGAGACTCTGTCTCAAAAAATAATAGGCCAGGCATGGTGGCTCAACGTCTGTAATCCCAGCACTTTGGG 1601 AGGCCGAGGCGGGCAGATCACAAGGTCAGGAGTTCGAGACCAGCCTGACGACCAACATGGTGAAACCTCGTCTCTACTAA 1681 AAATACAAAAATTAGCCAGGCCTGGTGGCACGCGCCTGTAATCCCAGTTACACAGAAGACTGAGGCAGGAGAATCGCTTG 1761 AACGCAGGAGGCAGAGGTTGCAGGAGCTGAGATCGCGCCATTGCACTCCAGCCTGGGCAACAGAGTGAGACTCTGTCTCA 1841 AAAAATAATAATAAAATAAATGAACACACATGCTGCTGAGTCCGCAGGGGGGGCAGAGCAGAGGACAGCGTGCTTTTGTG 1921 TACTGTTGGAAGACTGGCTCCTCCTGTACAGCACCTCTGAGCCCTTGTGCACCGCCCTGCCACGGGCACCATCCAGTCCT 2001 GGCCGTGTGACCACCCACAGCTGACTGGGCAGCAGGCACAGGCCCTACCCGAGCAGGCCGGAGTTGGCTCGCATGACTCC 2081 AGCTGAGGCTGCCTGTGTACATTTCTCCAGATACCCTATGGCTAATTTTGTTATAACTGCACAGTGGCTGCTGCCATTTT 2161 GTATTAAATATATTGTGAAACAAACCTATCTGGGGAGAAGCAATCTACTTGCCGCTGCTTCCTGTCTGGATCCAGCTTGT 2241 GTCCTTGGAGAGTGGCTGGCCCAGGTCCTATTCCTGTCCTCCAGCCCGTTCTTTCATGAGGGACAGGAAGGTAAAATCAG 2321 CCCTTAGGAGAGAGGTCTCAGCCTCCCTTTCCCAGATCTCCCAGTGAGTTTTAAAGGAAGCAGGGAGCCCAGAGTGCTAA 2401 GTTCTTACAGCCAGAAGGAAGCTTATAGATTTCTGAAAACCGCCCCTTTGTTTTTAAAAAGATCAACACAATTTGACTTT 2481 CTCAAGGTCAAAACGAACTAGAATCCAGATCTGCTCATGGCAAAAATGGGGGTGTTCTGAGAATTCCAGCTTTGGGCCGC 2561 ACTGTACAGCAGTCTGGATAGAGTGTGATCTGAGAAGGGAATGGGTCTGGGTTGTTCCACCCCTTCCGAGTTCCAAAAAG 2641 AGGGAACTGGTTTTCTTGGTTCTCAGCCCAGCAGCACCTATCCTGGCTCTTGGTCCTGGCCTGCAGCCAAGTGCTGTTCC 2721 TAGCCTGAGGCTTGAGACAGGTGGGGTTGGCTCCTCACCAACCCCAGTTCCGTCCCATCCTGAGGGCAAGATCCTGGGCT 2801 CATAGGCAGTCCCTTTCACTTCCTTGTCTTGCTCCCTGCTATGTTGGAGATGAATGTGACTAAAAGGGCCATCTTGCTGG 2881 CTTAATGTGTGGCTGGAGAGACCAGCCTGGAGACAATGTGGCAAAATGGGGCGCTTCATCCAGTCTGTCTAAGCCCTGTC 2961 GACTTGGGGAGGTGATTTCTTTCCTGGTTCTATATGTGAAGCAAAATAAATGTTTTAAAATTAAAAGCAAAAAAAACAAA 3041 ATGAACCATGAAAAAAAA Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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DRVs in gene 3'UTRs | |||||||||||||||||||||
SNPs in gene 3'UTRs |
Experimental Support 1 for Functional miRNA-Target Interaction | |||||||
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miRNA:Target | ---- | ||||||
Validation Method |
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Conditions | HEK293 | ||||||
Disease | 3712.0 | ||||||
Location of target site | 3'UTR | ||||||
Tools used in this research | TargetScan , miRTarCLIP , Piranha | ||||||
Original Description (Extracted from the article) |
...
"PAR-CLIP data was present in GSM1065667. RNA binding protein: AGO1. Condition:4-thiouridine
... - Memczak S; Jens M; Elefsinioti A; Torti F; et al., 2013, Nature. |
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miRNA-target interactions (Provided by authors) |
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Article |
- Memczak S; Jens M; Elefsinioti A; Torti F; et al. - Nature, 2013
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.
LinkOut: [PMID: 23446348]
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CLIP-seq Support 1 for dataset GSM4903833 | |
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Method / RBP | HITS-CLIP / AGO |
Cell line / Condition | Dermal fibroblasts / CTL_TD_21_a |
Location of target site | NM_001159508 | 3UTR | CACAGUGACUCAUGC |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Accession Series | GSE161239 |
CLIP-seq Viewer | Link |
CLIP-seq Support 2 for dataset GSM4903834 | |
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Method / RBP | HITS-CLIP / AGO |
Cell line / Condition | Dermal fibroblasts / CTL_TD_21_b |
Location of target site | NM_002225 | 3UTR | GCACAGUGACUCAUGCCUGUAAUCCCAACACUUUGGGAGGCCGAGGCAGGUGGAUCACGAGGUCAGGAGUUCAAGACCAGCCUGGCCAAGAUGGUAAAACCUCGUCUCUACUAAAAAUACAAAAAUUAGCCAGGUGUGGUGGCAG |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Accession Series | GSE161239 |
CLIP-seq Viewer | Link |
CLIP-seq Support 3 for dataset GSM4903837 | |
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Method / RBP | HITS-CLIP / AGO |
Cell line / Condition | Dermal fibroblasts / 124_TD_21_b |
Location of target site | NM_002225 | 3UTR | CACAGUGACUCAUGC |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Accession Series | GSE161239 |
CLIP-seq Viewer | Link |
CLIP-seq Support 4 for dataset GSM1065667 | |
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Method / RBP | PAR-CLIP / AGO1 |
Cell line / Condition | HEK293 / 4-thiouridine, ML_MM_6 |
Location of target site | ENST00000249760.2 | 3UTR | ACAGUGACUCAUGCCUGUAAUCCC |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23446348 / GSE43573 |
CLIP-seq Viewer | Link |
MiRNA-Target Expression Profile | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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MiRNA-Target Expression Profile (TCGA) | |||||||
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55 hsa-miR-1208 Target Genes:
Functional analysis:
ID | Target | Description | Validation methods | |||||||||
Strong evidence | Less strong evidence | |||||||||||
MIRT076103 | ADORA2B | adenosine A2b receptor | 2 | 2 | ||||||||
MIRT447464 | OSMR | oncostatin M receptor | 2 | 2 | ||||||||
MIRT448145 | ESF1 | ESF1 nucleolar pre-rRNA processing protein homolog | 2 | 2 | ||||||||
MIRT463639 | YY1 | YY1 transcription factor | 2 | 4 | ||||||||
MIRT465065 | TSR1 | TSR1, ribosome maturation factor | 2 | 2 | ||||||||
MIRT468464 | SET | SET nuclear proto-oncogene | 2 | 4 | ||||||||
MIRT480171 | CALM3 | calmodulin 3 | 2 | 2 | ||||||||
MIRT481495 | ARL6IP1 | ADP ribosylation factor like GTPase 6 interacting protein 1 | 2 | 8 | ||||||||
MIRT484111 | ABCD2 | ATP binding cassette subfamily D member 2 | 2 | 4 | ||||||||
MIRT499834 | PCSK9 | proprotein convertase subtilisin/kexin type 9 | 2 | 8 | ||||||||
MIRT500261 | ZNF788 | zinc finger family member 788 | 2 | 6 | ||||||||
MIRT500551 | XBP1P1 | X-box binding protein 1 pseudogene 1 | 2 | 8 | ||||||||
MIRT502697 | CSNK1G1 | casein kinase 1 gamma 1 | 2 | 4 | ||||||||
MIRT517786 | EFCAB11 | EF-hand calcium binding domain 11 | 2 | 2 | ||||||||
MIRT519191 | IVD | isovaleryl-CoA dehydrogenase | 2 | 2 | ||||||||
MIRT523114 | HSPA4L | heat shock protein family A (Hsp70) member 4 like | 2 | 2 | ||||||||
MIRT527425 | NRL | neural retina leucine zipper | 2 | 2 | ||||||||
MIRT529509 | IYD | iodotyrosine deiodinase | 2 | 2 | ||||||||
MIRT533705 | TMEM67 | transmembrane protein 67 | 2 | 2 | ||||||||
MIRT535694 | NEURL1B | neuralized E3 ubiquitin protein ligase 1B | 2 | 2 | ||||||||
MIRT536141 | MAPK14 | mitogen-activated protein kinase 14 | 2 | 2 | ||||||||
MIRT544878 | ZNF543 | zinc finger protein 543 | 2 | 4 | ||||||||
MIRT551362 | EPM2AIP1 | EPM2A interacting protein 1 | 2 | 2 | ||||||||
MIRT555949 | NUCKS1 | nuclear casein kinase and cyclin dependent kinase substrate 1 | 2 | 2 | ||||||||
MIRT561498 | SRSF2 | serine and arginine rich splicing factor 2 | 2 | 2 | ||||||||
MIRT569681 | AMACR | alpha-methylacyl-CoA racemase | 2 | 2 | ||||||||
MIRT572518 | KIAA0232 | KIAA0232 | 2 | 2 | ||||||||
MIRT572877 | OPHN1 | oligophrenin 1 | 2 | 2 | ||||||||
MIRT572924 | PRAMEF1 | PRAME family member 1 | 2 | 2 | ||||||||
MIRT607528 | ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 2 | 2 | ||||||||
MIRT611076 | ZNF621 | zinc finger protein 621 | 2 | 2 | ||||||||
MIRT613236 | CCDC39 | coiled-coil domain containing 39 | 2 | 2 | ||||||||
MIRT616542 | NFATC2 | nuclear factor of activated T-cells 2 | 2 | 2 | ||||||||
MIRT620010 | CCDC137 | coiled-coil domain containing 137 | 2 | 2 | ||||||||
MIRT621491 | STYK1 | serine/threonine/tyrosine kinase 1 | 2 | 2 | ||||||||
MIRT622379 | SALL1 | spalt like transcription factor 1 | 2 | 2 | ||||||||
MIRT628226 | FBXL20 | F-box and leucine rich repeat protein 20 | 2 | 2 | ||||||||
MIRT636458 | LRCH3 | leucine rich repeats and calponin homology domain containing 3 | 2 | 2 | ||||||||
MIRT636546 | FAM126B | family with sequence similarity 126 member B | 2 | 2 | ||||||||
MIRT637350 | PIGP | phosphatidylinositol glycan anchor biosynthesis class P | 2 | 2 | ||||||||
MIRT637604 | ZNF554 | zinc finger protein 554 | 2 | 2 | ||||||||
MIRT637732 | EXO5 | exonuclease 5 | 2 | 2 | ||||||||
MIRT638697 | GABRB1 | gamma-aminobutyric acid type A receptor beta1 subunit | 2 | 2 | ||||||||
MIRT640634 | ZIC4 | Zic family member 4 | 2 | 2 | ||||||||
MIRT641535 | SNW1 | SNW domain containing 1 | 2 | 2 | ||||||||
MIRT648796 | VPS8 | VPS8, CORVET complex subunit | 2 | 2 | ||||||||
MIRT663060 | LRIF1 | ligand dependent nuclear receptor interacting factor 1 | 2 | 2 | ||||||||
MIRT666581 | RHOBTB3 | Rho related BTB domain containing 3 | 2 | 2 | ||||||||
MIRT699206 | FYN | FYN proto-oncogene, Src family tyrosine kinase | 2 | 2 | ||||||||
MIRT704875 | CD164 | CD164 molecule | 2 | 2 | ||||||||
MIRT706850 | DNAJB13 | DnaJ heat shock protein family (Hsp40) member B13 | 2 | 2 | ||||||||
MIRT712941 | CCBE1 | collagen and calcium binding EGF domains 1 | 2 | 3 | ||||||||
MIRT714653 | FSTL1 | follistatin like 1 | 2 | 2 | ||||||||
MIRT722320 | SH2D1A | SH2 domain containing 1A | 2 | 2 | ||||||||
MIRT722535 | EPRS | glutamyl-prolyl-tRNA synthetase | 2 | 2 |
miRNA-Drug Associations | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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miRNA-Drug Resistance Associations | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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