miRTarBase - #MIRT519278


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pre-miRNA Information
pre-miRNA hsa-mir-4796   
Genomic Coordinates chr3: 114743445 - 114743525
Description Homo sapiens miR-4796 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4796-5p
Sequence 9| UGUCUAUACUCUGUCACUUUAC |30
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1466952984 15 dbSNP
rs887451291 21 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol DDX55   
Synonyms -
Description DEAD-box helicase 55
Transcript NM_020936   
Expression
Putative miRNA Targets on DDX55
3'UTR of DDX55
(miRNA target sites are highlighted)		 
>DDX55|NM_020936|3'UTR
   1 TTCCAGTGCCACAGATGAACCCACAAGGACATAGCTGTTCCCTAACTTGGTGGATGGCTCCAGTTTGCTTTTAACGAAAA
  81 TCACAACTTCAGGAGACATCTGAAAAGAATGATGTCTCTGAAAGCTGTCCTTTCAGATGAGGGAGAAATGAAGGATTTCA
 161 CACTTCAGAATATTTTACTAAAAACATTCCAGTCTTGGCCGGGTGCGGTGGCTCCTGCCTATAATCCCAGCACTTTGGGA
 241 GGCTGAGGCAGGAGGATCACTTGAGCCCAGGAGTTCAAGACCAGCCTGGGAACACAGCGAGACCCTCTCATTAAAAACAA
 321 CAAAACAAAACAATTCCAGTCTTGGAGTAGTCTAACAGAAGAAAATGTAAAATTATTTGAGTGTAAATAATAGATGTCAG
 401 TATTTATCATGATGGGTCACATATAGACATATGTACATATTATATATATATATATATATATATATATATATATATATATA
 481 TATATATAAGCTCTTTTTTCTGAGGCTATTTTATAGTTATTTTTAAACATAAAGATACAGAAGTCTTCTTGACTTCTGAT
 561 TTTCAAAACCATTCCTCAGTATCTTCAGGCATTTGACCTCCTGAATGTGCTTGGCCCTGGGCTTCAGTTATCCTTTGATG
 641 TCCTGCAGGGGTGGCTAATGTGCTGGGGTTTTTCTGTGTTAATAGTCACAGTATTGTTTTATTGGTGAATAGCTGAAAAA
 721 CAGAGGGATTAAGTCATATTCCGGGAAAGAGAATTATAGTTTTTATGCCTCCTGTTGAATAAATGGTGTCCTGATTGCCT
 801 GGG
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' cauUUCACUGUCUCAUAUCUGu 5'
             ::|| |||   ||||||| 
Target 5' gatGGGTCACA---TATAGACa 3'
 411 - 429 152.00 -9.90
2 
miRNA  3' caUUUCACUGUCUCAUAUCugu 5'
            |||| ||   | |||||   
Target 5' ggAAAGAGA---ATTATAGttt 3'
 744 - 762 117.00 -6.52
3 
miRNA  3' cauUUCACUGUCUCAUAUCUGu 5'
             :|||| :| |  |||||: 
Target 5' tttGAGTG-TAAATAATAGATg 3'
 376 - 396 110.00 -6.22
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN1143823 17 COSMIC
COSN30457366 23 COSMIC
COSN8407320 23 COSMIC
COSN31532363 28 COSMIC
COSN27217143 33 COSMIC
COSN19693240 76 COSMIC
COSN31577116 93 COSMIC
COSN31493085 117 COSMIC
COSN27999553 328 COSMIC
COSN29744175 489 COSMIC
COSN5316977 550 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1194848095 6 dbSNP
rs763991921 7 dbSNP
rs1479754572 9 dbSNP
rs1215830609 13 dbSNP
rs1330916394 16 dbSNP
rs751343691 21 dbSNP
rs757028695 22 dbSNP
rs374905902 24 dbSNP
rs1467753903 26 dbSNP
rs535813775 33 dbSNP
rs369047368 35 dbSNP
rs754249667 41 dbSNP
rs897167558 43 dbSNP
rs1298604374 45 dbSNP
rs750323677 49 dbSNP
rs756332192 50 dbSNP
rs1282060842 51 dbSNP
rs1305321637 58 dbSNP
rs566778751 62 dbSNP
rs938597159 64 dbSNP
rs1027184372 67 dbSNP
rs953114285 73 dbSNP
rs1057392236 76 dbSNP
rs757631981 77 dbSNP
rs756366010 99 dbSNP
rs534235515 108 dbSNP
rs1018887242 111 dbSNP
rs1013126711 117 dbSNP
rs964462689 120 dbSNP
rs1021340129 139 dbSNP
rs1201442270 141 dbSNP
rs1434068152 162 dbSNP
rs975848158 175 dbSNP
rs1189654648 187 dbSNP
rs1481671947 200 dbSNP
rs904253088 201 dbSNP
rs922892296 202 dbSNP
rs1339973706 203 dbSNP
rs934307332 204 dbSNP
rs988515166 207 dbSNP
rs914474567 208 dbSNP
rs1298765249 215 dbSNP
rs965629551 218 dbSNP
rs1350614063 220 dbSNP
rs1379670935 221 dbSNP
rs749066145 242 dbSNP
rs1429732787 246 dbSNP
rs947322045 248 dbSNP
rs142193554 250 dbSNP
rs1308691966 254 dbSNP
rs1348680954 261 dbSNP
rs1221194287 268 dbSNP
rs1276742401 272 dbSNP
rs905713204 275 dbSNP
rs1377376483 277 dbSNP
rs938743646 279 dbSNP
rs754893205 282 dbSNP
rs1057151639 285 dbSNP
rs1473680077 287 dbSNP
rs1310242786 288 dbSNP
rs1181537421 291 dbSNP
rs897277072 297 dbSNP
rs367894750 299 dbSNP
rs1238720467 300 dbSNP
rs984667037 305 dbSNP
rs1176689673 309 dbSNP
rs1026965348 326 dbSNP
rs1240827032 340 dbSNP
rs940066884 341 dbSNP
rs888690160 342 dbSNP
rs1287256486 348 dbSNP
rs972756584 350 dbSNP
rs927941697 358 dbSNP
rs1336744573 362 dbSNP
rs199916746 362 dbSNP
rs1401997522 390 dbSNP
rs1007565752 391 dbSNP
rs1171184913 393 dbSNP
rs1422566340 396 dbSNP
rs1018420927 411 dbSNP
rs1158652615 412 dbSNP
rs1471662011 419 dbSNP
rs965931210 424 dbSNP
rs1370241516 425 dbSNP
rs544819353 428 dbSNP
rs1472391004 429 dbSNP
rs7970984 429 dbSNP
rs188947506 430 dbSNP
rs1465129211 431 dbSNP
rs1267137824 434 dbSNP
rs1203153416 437 dbSNP
rs1226138918 437 dbSNP
rs1284247917 437 dbSNP
rs1336373907 437 dbSNP
rs1246259952 438 dbSNP
rs1402891627 438 dbSNP
rs1320197006 440 dbSNP
rs1332707995 440 dbSNP
rs1455809647 440 dbSNP
rs1491455828 440 dbSNP
rs1170465853 441 dbSNP
rs1186434519 441 dbSNP
rs1197657666 441 dbSNP
rs1213182731 441 dbSNP
rs1246934405 441 dbSNP
rs1274476691 441 dbSNP
rs1276112043 441 dbSNP
rs1297313957 441 dbSNP
rs1333058476 441 dbSNP
rs1340049618 441 dbSNP
rs1343482610 441 dbSNP
rs1370127978 441 dbSNP
rs1388611462 441 dbSNP
rs1389402003 441 dbSNP
rs1404872548 441 dbSNP
rs1430298472 441 dbSNP
rs1433242459 441 dbSNP
rs1449422438 441 dbSNP
rs1478855720 441 dbSNP
rs1491406627 441 dbSNP
rs68169681 441 dbSNP
rs72315336 441 dbSNP
rs988464120 441 dbSNP
rs1275689527 442 dbSNP
rs1309929739 442 dbSNP
rs1329459603 442 dbSNP
rs1410421401 442 dbSNP
rs56797980 442 dbSNP
rs1040535547 443 dbSNP
rs58259285 444 dbSNP
rs1371878835 445 dbSNP
rs1438644142 447 dbSNP
rs1171675710 448 dbSNP
rs1273330915 449 dbSNP
rs1253418046 451 dbSNP
rs1367092898 451 dbSNP
rs1218445239 452 dbSNP
rs1258539348 453 dbSNP
rs1319735412 455 dbSNP
rs1202978833 456 dbSNP
rs938638430 457 dbSNP
rs1218930632 458 dbSNP
rs1279746341 458 dbSNP
rs1257287113 459 dbSNP
rs1321661221 459 dbSNP
rs1290388490 461 dbSNP
rs1451704702 462 dbSNP
rs1200287186 466 dbSNP
rs1296429170 467 dbSNP
rs1359591143 468 dbSNP
rs1450087578 468 dbSNP
rs1057052497 469 dbSNP
rs1159389838 470 dbSNP
rs1244631974 470 dbSNP
rs1176028026 472 dbSNP
rs1484523539 472 dbSNP
rs1238472407 473 dbSNP
rs1209877167 474 dbSNP
rs1460210774 475 dbSNP
rs1477524130 476 dbSNP
rs1328628145 478 dbSNP
rs866140766 478 dbSNP
rs1304949657 479 dbSNP
rs58348785 479 dbSNP
rs113382418 480 dbSNP
rs1379818886 480 dbSNP
rs1456352286 481 dbSNP
rs571625500 481 dbSNP
rs1426283809 482 dbSNP
rs1166276714 484 dbSNP
rs868413659 486 dbSNP
rs1464371070 487 dbSNP
rs1250251932 488 dbSNP
rs3209852 488 dbSNP
rs980432155 490 dbSNP
rs1170623649 491 dbSNP
rs1298057685 492 dbSNP
rs927116643 492 dbSNP
rs1433982358 501 dbSNP
rs1359447250 509 dbSNP
rs1294856718 516 dbSNP
rs1348747171 520 dbSNP
rs1163568329 532 dbSNP
rs1395805350 539 dbSNP
rs938508188 539 dbSNP
rs3190836 540 dbSNP
rs918651251 541 dbSNP
rs560490665 546 dbSNP
rs1193085774 557 dbSNP
rs1488876203 560 dbSNP
rs930088602 566 dbSNP
rs1048352184 572 dbSNP
rs113933929 573 dbSNP
rs1220252735 580 dbSNP
rs1431839934 587 dbSNP
rs1280306554 594 dbSNP
rs1275196996 605 dbSNP
rs894352138 607 dbSNP
rs118095783 610 dbSNP
rs1216523185 614 dbSNP
rs1302989311 617 dbSNP
rs1386972370 618 dbSNP
rs1007102610 633 dbSNP
rs1042847471 637 dbSNP
rs904305561 638 dbSNP
rs3190835 642 dbSNP
rs55705511 650 dbSNP
rs998336953 657 dbSNP
rs1461814828 658 dbSNP
rs998226132 667 dbSNP
rs1031205084 669 dbSNP
rs1287209685 675 dbSNP
rs184470082 692 dbSNP
rs1266836309 702 dbSNP
rs1197381282 703 dbSNP
rs1484039772 707 dbSNP
rs550380443 718 dbSNP
rs1252494665 720 dbSNP
rs1204294885 721 dbSNP
rs1479566862 726 dbSNP
rs1257512226 728 dbSNP
rs1450505973 743 dbSNP
rs1216947849 744 dbSNP
rs1264820949 745 dbSNP
rs1028587136 752 dbSNP
rs145887517 757 dbSNP
rs542919943 769 dbSNP
rs1021253008 770 dbSNP
rs968800233 775 dbSNP
rs1017099276 786 dbSNP
rs1391290916 789 dbSNP
rs961487280 793 dbSNP
rs979824586 796 dbSNP
rs1466821416 799 dbSNP
rs927997270 802 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 57696.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM1065667. RNA binding protein: AGO1. Condition:4-thiouridine ...

- Memczak S; Jens M; Elefsinioti A; Torti F; et al., 2013, Nature.

Article - Memczak S; Jens M; Elefsinioti A; Torti F; et al.
- Nature, 2013
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.
LinkOut: [PMID: 23446348]
CLIP-seq Support 1 for dataset GSM1065667
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / 4-thiouridine, ML_MM_6
Location of target site ENST00000238146.4 | 3UTR | ACAUAUGUACAUAUUAUAUAUAUAUAUAUAUAUAUAUAUAUAUAUAUAUAUAUAUAUAUAUAAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
29 hsa-miR-4796-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT446014 VNN1 vanin 1 2 2
MIRT493828 FRS2 fibroblast growth factor receptor substrate 2 2 6
MIRT506324 ONECUT2 one cut homeobox 2 2 2
MIRT515488 PRKCD protein kinase C delta 2 4
MIRT515543 KRT222 keratin 222 2 4
MIRT518502 DEPTOR DEP domain containing MTOR interacting protein 2 6
MIRT519278 DDX55 DEAD-box helicase 55 2 2
MIRT528638 SENP6 SUMO1/sentrin specific peptidase 6 2 2
MIRT532130 NOL11 nucleolar protein 11 2 2
MIRT558240 EDA2R ectodysplasin A2 receptor 2 2
MIRT562293 GLO1 glyoxalase I 2 2
MIRT575346 Cacul1 CDK2 associated, cullin domain 1 2 2
MIRT610250 SLC35B4 solute carrier family 35 member B4 2 2
MIRT616752 SVOP SV2 related protein 2 2
MIRT627810 PTCHD1 patched domain containing 1 2 4
MIRT643062 CCDC149 coiled-coil domain containing 149 2 2
MIRT652031 LINC00598 long intergenic non-protein coding RNA 598 2 2
MIRT658708 EMB embigin 2 2
MIRT687624 LRRC40 leucine rich repeat containing 40 2 2
MIRT692723 INPP5B inositol polyphosphate-5-phosphatase B 2 2
MIRT697508 ZBTB7A zinc finger and BTB domain containing 7A 2 2
MIRT702301 LAMP3 lysosomal associated membrane protein 3 2 2
MIRT718288 MINA ribosomal oxygenase 2 2 2
MIRT755767 BRCC3 BRCA1/BRCA2-containing complex subunit 3 5 1
MIRT755769 BARD1 BRCA1 associated RING domain 1 5 1
MIRT755770 ATM ATM serine/threonine kinase 5 1
MIRT755771 PARP14 poly(ADP-ribose) polymerase family member 14 5 1
MIRT755775 PARP2 poly(ADP-ribose) polymerase 2 5 1
MIRT755777 PARP11 poly(ADP-ribose) polymerase family member 11 5 1
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4796-5p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-4796-5p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-4796-5p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)

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