pre-miRNA Information | |
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pre-miRNA | hsa-mir-4752 |
Genomic Coordinates | chr19: 54282109 - 54282180 |
Description | Homo sapiens miR-4752 stem-loop |
Comment | None |
RNA Secondary Structure |
Mature miRNA Information | ||||||||||||||||
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Mature miRNA | hsa-miR-4752 | |||||||||||||||
Sequence | 10| UUGUGGAUCUCAAGGAUGUGCU |31 | |||||||||||||||
Evidence | Experimental | |||||||||||||||
Experiments | Illumina | |||||||||||||||
SNPs in miRNA |
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Putative Targets |
Gene Information | |||||||||||||||||||||
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Gene Symbol | ZNF772 | ||||||||||||||||||||
Synonyms | - | ||||||||||||||||||||
Description | zinc finger protein 772 | ||||||||||||||||||||
Transcript | NM_001024596 | ||||||||||||||||||||
Other Transcripts | NM_001144068 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on ZNF772 | |||||||||||||||||||||
3'UTR of ZNF772 (miRNA target sites are highlighted) |
>ZNF772|NM_001024596|3'UTR 1 GATGGGAGATAATTCCGTTTCCTTGTTCAACATAATAACTGACATCAGAGAGAAGCTCCAAGCATAGCCTTTATGTGTAG 81 CCGACAGCCAGAAGTAGAACTTTATACACTCAAACACTCACCCTGGGGAGGTTCTTCCGAGTGCCAGCTATATGGGAAGC 161 CTTCTGGAGCTATGCTGAATTTTCTAGACTCTTGCTGGAATTTCGTCAAGGCAGTGCCTGTTAGAAGCCATCTGTCTTTG 241 TGCTGGAAGAGTCCTGCCTTGTGCCAAAGTAACCCCAATGTGTTTCAAAAGACAGACCTCTGTACTATTCCCTTCCCTGG 321 AGGGAATCATCAGTAGCCTGAGGCCATCAAGGATTCTCACTTTTTTTCTGCCCCACTACTGGTTTAAGCATGAGCATGAC 401 CCAGTTTTAGCCAGAAAAATGGGAGCTTTGTTCTGCTGACCACTGGCAGAGGTTTCCCTTCATGGATATAGTTGATCTCA 481 CATGGCACTTGGGACGAATTTTTCTAGCCTTCAAGACACCTGACCTGAAATTGGCTGCCTCATATTCTGGTTTTGCAACA 561 AATGCCTTAATTTTTAGACTATCTGAAATCTTGAGGATTCTGTTCGCTTTGTGGGTTGGGTTGAGAACAGAATTGAGCTA 641 AGCCAGTATGAAGGGAAGAACAGCTTTTGTGAGAGCTCCAACTATCTGTATCTCTGAAGTGATAGTAGGATGGCAAAGAC 721 TAGCTCTTATGCTAGTGTCAAGCTAACTTACTTGACTGCTTCAGCTCTCCTAGGAAAGAATGCCAGTCTTTGTAGGCCTA 801 ATCTTTTGGTCTATATGTTAAGATTTTTTGTGTAATTGAGGTCACCCTAAGCAGTGGGCATTTGTTGTGATAATCTCTAA 881 TGTGTCTGGGAGCAACATGAATTACGTCCCTTGTTCCCAGAAGATACTTCATATTCCCAAGGCTTCTTGAGGAGAATTTG 961 AACTCAGTGGACATGTCAAGATCTCTGAAGTCTATTTTTCAGTAGGCAGTTGATATTGGCTGTCCTCCAGAAGGCCCAGG 1041 TAGGAATCATAGTTGGTGCAGAAACCCAGATTAATAAAGGAATGAGAAAACTGCAGCAAACTATAGGGAATATGACCCTT 1121 CTAAAGGTACATCCACATGTGTTTCCATTACTCTGGCTCCATTATGAGGGTTTACAGAAATATTTCCATACCTGTGTCTC 1201 TTATGGCTAAGGTTACTGTCCAGAAGTCAGTCTAAACATTTTTGCAATAAACTGCACATATTTATAGTGTACCATTTGAT 1281 AAGTTTTGATACATGTTGGCACTTCTCAAACCAAAAGTTTCCTGATTCCTTTTATATTTTCTCCCTTTCCTTCACCCATC 1361 CCCAGGCAACTATTGATCCGTTGTCACTGTAGATTTGTTTGTATTTCCTAGAATTCTACAGAGATAGAGTAATTTAATAT 1441 GTATTCTAATGTTTTTGGCTTCTTAAACTCTGAAATTAAGGCTCATGGTGGTGTTCTGTGTTTCATAGTTCATTTCTTTT 1521 CATTTGTACTTTGCTAAGAGTGTTCCATTGTAGAGAAATAGTTTCAAAGCAAGTGATCCAGGAGAGAACTCACACAAGAA 1601 CAAAGCCACAGTATCTGTCATTACCTTAAACTGAAAGTGATGAGCCGTCATTTCTGCTATATTTCATAAGTAACCCTAGC 1681 TAATCCTGGTTAAAAGTGGAAGAGAACTACACAAAGGTGAAAATAGGGATTTGTGGGGCGTTTTCTTGGACTCTGGTGAC 1761 CATAATCCTATATGGTTTTTTTCTTTTTCTGTTTTAGTTGTTTAATATGAATTACATTGACTGATTTTTTTAAATGTTAA 1841 GCCAACCTTGCATTTCTGTAATAATTCCCATTTGGTCATGATGTATTAGTCATTTAGTATATTGTTGAATTTGATTTGCT 1921 ATTTTGTTTTGTTTTGTTTTGTTTTTTTGTAACAAGTTTTGCACCAATGTTCACGAGTGATATTTGTCCCTAACTTTCTT 2001 TCTTGCTTGCTTGCTTTTTTTTCTTTGTAATTTTATATCTTGCCCAGGTTTGGCTTTGGTATCAGCATAATGCCAGCTTT 2081 ATAGAGTAAGTTGGGAAGTATTCCTGCTCTTCAGCTCTCTGGAAGAGTTTGTGAATAATTGGTATTATTTCTTCCTTAAA 2161 TGTTTGGTAGAATTCACCAAGGAAGCTGTCTGGGCCTGGAGTTTGTTTTGTAGGAAAGTTTCTAACTATAAGTTTGATTT 2241 CTGTGGTAGATAGAGGGCTGTACAAGTTATATGTACATCTGTCTGTGTGTGTGTTGTCTGTCTGTCACTCTGGCCCTGAA 2321 GTGTGTTTTGTAGGACAGCATCTAACTACAAGTTTGATTTCCATGGTAGATGGAGGGCTATACTAGTTATATATACATCT 2401 GTCTGTCCGTCCATCTGTTTGTCACTCCATCCATCCATCTATCTCTAGAGTGAGCTTTGATGGTTTGTGTCTTTCAAGGA 2481 GTTTTTCTGTTTTATTTAAGTACTCAAATTTTTCAAAATATTATTTTCATACTTGTAGAATTTGTAGTGGTGCAACCTCT 2561 TCTATTCCTGATACTGGTAATGTCTATATTTTTCTTTTAACCTTGATTGGTTTGGGTAGAGATTTATCAATTTTACAATT 2641 TTATTGATCTTAAAGTACTTGGTATTATTGAATTTTCTGTTTTCTGATATTTTGGGATTTTTCTTTTCCATTTTGAGTTT 2721 TACTAATGCCTTCCGCTTTTATTGGATTTCATTTCTTTTGCTACTTTTTAACATGGAAGCTGAGGTCCTTCATTTCAAAC 2801 CTTTGGGTTTTTTTCCCCTAATATGGGGAAGAGATGTTAATGTTAAAAATCTATCTGAGAACTGCTTTAATTACCTCCCA 2881 TCAAGCTTGATGTGGTTTCATTTTTTTTTTTGAGACAGTGTCTTGCTCTGTCATCCAGGTTGGAGTGCAGTGGCGCGATC 2961 TCGGCTCACTGCAAGCTCTGCCTCCTGGGTTCACACCATTCTCCTGCCTCAGCCTCCCGAGTAGCTTGGACTACAGGCGC 3041 CTGCCACCATGCCTGGCTAATTTTTTGTATTTTTAGTAGAGACGAGGTTTCACCGTGTTAGCCAGGATGGTCTCGATCTC 3121 CTGATCTTGTGATCCGCCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCCAGCCGATGTGGTTTCATTTT 3201 AGTTGAGTTTAGGATGTTTTCCAGTTAAAAAAATTCTTCTTGACACATGGCTCTTTTTAAATGTATGTTATTTAATTCCT 3281 AAATATTTGGGGATTTTGCTTATCTTTCTGGTAGTTTCTGCAATAATTCCATTGTGGTCAGAGTACATTAAGACTTGAAT 3361 TATTTACATTTATTGAGATTTGCTTTGTGGCCCAGAATATGGGCTATCTTGGTATGAGTTACATGTTCACTTGAAATGTA 3441 TACTGTACTCTCGTTTGATGAAGGGGTTCTACAAGTGTTGATTAGGTAAAAATGGTTGATGTTATTTAAGTTTTTTCTAT 3521 CTTTATTGACATTCTGTGGTTTTGGTTCCAGCAATTATTTTAAGAGGATTGTTGACATCTCTGAATATTAAATTGGATTT 3601 ACTTCTCTGCAGTTCTGTCAGATTTTGCTTCACATATTTTAGTATGTTTTTATTAGGTGAATAATAAATATTTCCTATTT 3681 TATGTCCAAAAAAAAAAAAAAAA Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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DRVs in gene 3'UTRs | |||||||||||||||||||||
SNPs in gene 3'UTRs |
Experimental Support 1 for Functional miRNA-Target Interaction | |
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miRNA:Target | ---- |
Validation Method |
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Conditions | HEK293 |
Location of target site | 3'UTR |
Tools used in this research | TargetScan , miRTarCLIP , Piranha |
Original Description (Extracted from the article) |
...
PAR-CLIP data was present in GSM545212. RNA binding protein: AGO1. Condition:Control
PAR-CLIP data was present in GSM545214. RNA binding protein: AGO3. Condition:Control
PAR-CLIP data was present in GSM545216. RNA binding protein: AGO2. Condition:miR-124 transfection
PAR-CLIP data was present in GSM545217. RNA binding protein: AGO2. Condition:miR-7 transfection
... - Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell. |
Article |
- Hafner M; Landthaler M; Burger L; Khorshid et al. - Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
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Experimental Support 2 for Functional miRNA-Target Interaction | |
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miRNA:Target | ---- |
Validation Method |
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Conditions | HEK293 |
Disease | 400720.0 |
Location of target site | 3'UTR |
Tools used in this research | TargetScan , miRTarCLIP , Piranha |
Original Description (Extracted from the article) |
...
"PAR-CLIP data was present in GSM1065667. RNA binding protein: AGO1. Condition:4-thiouridine
... - Memczak S; Jens M; Elefsinioti A; Torti F; et al., 2013, Nature. |
Article |
- Memczak S; Jens M; Elefsinioti A; Torti F; et al. - Nature, 2013
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.
LinkOut: [PMID: 23446348]
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CLIP-seq Support 1 for dataset GSM545212 | |
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Method / RBP | PAR-CLIP / AGO1 |
Cell line / Condition | HEK293 / Control |
Location of target site | ENST00000425074.3 | 3UTR | aauccacacuggagaaaugccuuaugag |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 20371350 / GSE21578 |
CLIP-seq Viewer | Link |
CLIP-seq Support 2 for dataset GSM545214 | |
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Method / RBP | PAR-CLIP / AGO3 |
Cell line / Condition | HEK293 / Control |
Location of target site | ENST00000425074.3 | 3UTR | aauccacacuggagaaaugccuuaug |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 20371350 / GSE21578 |
CLIP-seq Viewer | Link |
CLIP-seq Support 3 for dataset GSM545216 | |
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Method / RBP | PAR-CLIP / AGO2 |
Cell line / Condition | HEK293 / miR-124 transfection |
Location of target site | ENST00000425074.3 | 3UTR | aauccacacuggagaaaugccuuauga |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 20371350 / GSE21578 |
CLIP-seq Viewer | Link |
CLIP-seq Support 4 for dataset GSM545217 | |
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Method / RBP | PAR-CLIP / AGO2 |
Cell line / Condition | HEK293 / miR-7 transfection |
Location of target site | ENST00000425074.3 | 3UTR | aauccacacuggagaaaugccuuaug |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 20371350 / GSE21578 |
CLIP-seq Viewer | Link |
CLIP-seq Support 5 for dataset GSM1065667 | |
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Method / RBP | PAR-CLIP / AGO1 |
Cell line / Condition | HEK293 / 4-thiouridine, ML_MM_6 |
Location of target site | ENST00000425074.3 | 3UTR | aauccacacuggagaaaugccuuaugag |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23446348 / GSE43573 |
CLIP-seq Viewer | Link |
MiRNA-Target Expression Profile | |||||||
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MiRNA-Target Expression Profile (TCGA) | |||||||
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57 hsa-miR-4752 Target Genes:
Functional analysis:
ID | Target | Description | Validation methods | |||||||||
Strong evidence | Less strong evidence | |||||||||||
MIRT291951 | TPM4 | tropomyosin 4 | 2 | 2 | ||||||||
MIRT293610 | PVR | poliovirus receptor | 2 | 2 | ||||||||
MIRT454768 | STOML3 | stomatin like 3 | 2 | 2 | ||||||||
MIRT463215 | ZNF131 | zinc finger protein 131 | 2 | 2 | ||||||||
MIRT464138 | VPS28 | VPS28, ESCRT-I subunit | 2 | 2 | ||||||||
MIRT469361 | REST | RE1 silencing transcription factor | 2 | 6 | ||||||||
MIRT470819 | PLXND1 | plexin D1 | 2 | 2 | ||||||||
MIRT478874 | CREBRF | CREB3 regulatory factor | 2 | 2 | ||||||||
MIRT480240 | C8orf58 | chromosome 8 open reading frame 58 | 2 | 2 | ||||||||
MIRT480544 | BZW1 | basic leucine zipper and W2 domains 1 | 2 | 2 | ||||||||
MIRT480923 | BCAT1 | branched chain amino acid transaminase 1 | 2 | 4 | ||||||||
MIRT497342 | RPP25L | ribonuclease P/MRP subunit p25 like | 2 | 2 | ||||||||
MIRT498823 | DNTTIP2 | deoxynucleotidyltransferase terminal interacting protein 2 | 2 | 8 | ||||||||
MIRT498927 | TMEM106B | transmembrane protein 106B | 2 | 8 | ||||||||
MIRT499583 | INTU | inturned planar cell polarity protein | 2 | 4 | ||||||||
MIRT500117 | ZNF106 | zinc finger protein 106 | 2 | 4 | ||||||||
MIRT500473 | ZC3H11A | zinc finger CCCH-type containing 11A | 2 | 2 | ||||||||
MIRT501907 | MBD4 | methyl-CpG binding domain 4, DNA glycosylase | 2 | 4 | ||||||||
MIRT519636 | ZNF772 | zinc finger protein 772 | 2 | 4 | ||||||||
MIRT533402 | TXLNG | taxilin gamma | 2 | 2 | ||||||||
MIRT546181 | TPRG1L | tumor protein p63 regulated 1 like | 2 | 2 | ||||||||
MIRT546486 | SKI | SKI proto-oncogene | 2 | 4 | ||||||||
MIRT549398 | AKAP11 | A-kinase anchoring protein 11 | 2 | 2 | ||||||||
MIRT552282 | CBY1 | chibby family member 1, beta catenin antagonist | 2 | 4 | ||||||||
MIRT558980 | CA8 | carbonic anhydrase 8 | 2 | 2 | ||||||||
MIRT559812 | ZNF83 | zinc finger protein 83 | 2 | 2 | ||||||||
MIRT559923 | SOD2 | superoxide dismutase 2 | 2 | 2 | ||||||||
MIRT560257 | TMEM236 | transmembrane protein 236 | 2 | 2 | ||||||||
MIRT560419 | ANGPTL3 | angiopoietin like 3 | 2 | 2 | ||||||||
MIRT560548 | SIGLEC14 | sialic acid binding Ig like lectin 14 | 2 | 2 | ||||||||
MIRT560803 | PPIP5K2 | diphosphoinositol pentakisphosphate kinase 2 | 2 | 2 | ||||||||
MIRT560882 | SULT1B1 | sulfotransferase family 1B member 1 | 2 | 2 | ||||||||
MIRT560996 | C8orf37 | chromosome 8 open reading frame 37 | 2 | 2 | ||||||||
MIRT561089 | DNAJC10 | DnaJ heat shock protein family (Hsp40) member C10 | 2 | 2 | ||||||||
MIRT561192 | LDHD | lactate dehydrogenase D | 2 | 2 | ||||||||
MIRT561834 | NREP | neuronal regeneration related protein | 2 | 2 | ||||||||
MIRT561997 | LPP | LIM domain containing preferred translocation partner in lipoma | 2 | 2 | ||||||||
MIRT562394 | EIF4E | eukaryotic translation initiation factor 4E | 2 | 2 | ||||||||
MIRT566265 | PTAR1 | protein prenyltransferase alpha subunit repeat containing 1 | 2 | 2 | ||||||||
MIRT572724 | NUP188 | nucleoporin 188 | 2 | 2 | ||||||||
MIRT620359 | CD55 | CD55 molecule (Cromer blood group) | 2 | 2 | ||||||||
MIRT623578 | IREB2 | iron responsive element binding protein 2 | 2 | 2 | ||||||||
MIRT627122 | GRN | granulin precursor | 2 | 2 | ||||||||
MIRT640725 | PHF13 | PHD finger protein 13 | 2 | 2 | ||||||||
MIRT651578 | WDR26 | WD repeat domain 26 | 2 | 2 | ||||||||
MIRT655000 | PLAG1 | PLAG1 zinc finger | 2 | 2 | ||||||||
MIRT659673 | CD86 | CD86 molecule | 2 | 2 | ||||||||
MIRT667164 | NRXN1 | neurexin 1 | 2 | 2 | ||||||||
MIRT674926 | C1orf116 | chromosome 1 open reading frame 116 | 2 | 2 | ||||||||
MIRT687377 | NT5DC3 | 5'-nucleotidase domain containing 3 | 2 | 2 | ||||||||
MIRT690438 | REPIN1 | replication initiator 1 | 2 | 2 | ||||||||
MIRT695288 | TK1 | thymidine kinase 1 | 2 | 2 | ||||||||
MIRT699809 | SDHD | succinate dehydrogenase complex subunit D | 2 | 2 | ||||||||
MIRT710100 | HEY2 | hes related family bHLH transcription factor with YRPW motif 2 | 2 | 2 | ||||||||
MIRT717882 | GBP4 | guanylate binding protein 4 | 2 | 2 | ||||||||
MIRT719957 | SAMD15 | sterile alpha motif domain containing 15 | 2 | 2 | ||||||||
MIRT725588 | CDH7 | cadherin 7 | 2 | 2 |
miRNA-Drug Associations | ||||||||||||||||||
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miRNA-Drug Resistance Associations | ||||||||||||||||||||||||||||||
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