pre-miRNA Information | |
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pre-miRNA | hsa-mir-758 |
Genomic Coordinates | chr14: 101026020 - 101026107 |
Synonyms | MIRN758, hsa-mir-758, MIR758 |
Description | Homo sapiens miR-758 stem-loop |
Comment | None |
RNA Secondary Structure | ![]() |
Associated Diseases | ![]() |
Mature miRNA Information | ||||||||||||||||||||||||||||||||||||||||||||||
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Mature miRNA | hsa-miR-758-5p | |||||||||||||||||||||||||||||||||||||||||||||
Sequence | 15| GAUGGUUGACCAGAGAGCACAC |36 | |||||||||||||||||||||||||||||||||||||||||||||
Evidence | Experimental | |||||||||||||||||||||||||||||||||||||||||||||
Experiments | SOLiD | |||||||||||||||||||||||||||||||||||||||||||||
Editing Events in miRNAs |
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SNPs in miRNA |
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Putative Targets |
miRNA Expression profile | |
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Human miRNA Tissue Atlas | |
miRNAs in Extracellular Vesicles |
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Circulating MicroRNA Expression Profiling |
Gene Information | |||||||||||||||||||||
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Gene Symbol | ZNF512B | ||||||||||||||||||||
Synonyms | GM632 | ||||||||||||||||||||
Description | zinc finger protein 512B | ||||||||||||||||||||
Transcript | NM_020713 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on ZNF512B | |||||||||||||||||||||
3'UTR of ZNF512B (miRNA target sites are highlighted) |
>ZNF512B|NM_020713|3'UTR 1 GCATGGTGCGTGGGGCCTGGCCCCCATGCAGCCGCCACACCGCCCTCTGTTCAAGGCAGGGCCAGCTCCGGGACCTCTGT 81 CCTCCAGTTCTCCATCCCCCACCCCCGCCTCTTCATCCGTCCAGTGGGGCAGCCAGCCACTCTCCCTTCCCTGAAGGTGG 161 CCCTTCCCCTGTTAAGGCTGCCACAGGGCACACCTGGGTTGGGGCTCCCCAAGGTGTGCCCAGCAGAAGTGCAATAGCCA 241 GGAGGGTTGCCCCTCCTCATGGGAATGTGTCTGGGGTCTTGGTGCCACAGGGGCTGCAGCGCAGAGTAGGCAGATGGCCT 321 TTGGCCCCCCGGCTCCGCTTCCTCAGGCCCTGCCGGGTCCCTTCCCTGGCTACCCCAAGGCTCAGGCATCCCTGGTGACC 401 TGTGGTTCTGGGCTGGTGAGGGCACCTGAGCAACCTGGCACGGGCAGCCACCATCCTGGCCTCACCTCCACCCAACACTG 481 GAACTCCAGCACCCCCAGCTACCTCCCAGGACAGACCCCTGTCTGACCACTGCCATGCTGACCTGACAGGCTCCGGCCTG 561 CCCTTGGCCACCCACTTGGTCCCCTTGCTTCTGTTTTCTACCTCTCCAGGCCTGCCCACTACCCCCACCCCTGCTCCTCC 641 TTTGTCAGTGCGATCCCTGCTGTGCTCAGGCCCTGCCCCCCAGGCCTGTCTGTAATTCTCCCAGCTTGGGGCAAGGGAGG 721 GGTTTTGCTTCTTGTACCTACAGGGCAGCAGAAGCTTGATGCCCTTCAACACAGCTGCCAGCCCTGGGGGTGTGGGGCCC 801 CTGGAGTGTGCTCTCCTCCAGTGTTCAGCCTTCTGGCACTGCAGGCCTAGGTTGGAGCAGCCTCGTGGAGTAGGGACGGA 881 CTAGTTCGGGCCCTGGGGTCTTGCTGGGGCCCATAGGCATGTGGGGCAGGAAGCTGGGCAGAGCTGGCCTGGCTCTGAGT 961 GGCCACTGGGGGAAAGGCAGCCTTCTGTCTGCCAATCTGGGTAGGCCCAGTGGCCAAGCTCTCATGGGAGCCCCCTCCCC 1041 ACTTTTTTTTTTAACCTGCCCCCATTGTTTCTGGTTGTGTGGTCATTTGATATGGGAACTGAAGGCCAGCCAGGGGAGGG 1121 GCTTGGCCAAAGTCACAGCAGGTTGATGGCAGCTCCAGAGCTGTCTTTGCCCCTTTGTGGCCCTGAGGACGGCTGGGTCT 1201 ATAGGTAGGGCAGGGGTCAGGCAGGGAGTCCAGGGTGCCTGGAAGAGGTGGCCACAGCCTGTGGCTCCCTCCCTGGGGTC 1281 CTGCCTTCCAACCACGGCATTGCAGGGAGGATGAGGCTCAGAGGGGGTAGGTTTGGAGGGAGGCCATTTTCCAGGGTGGG 1361 TGGGAGTGGGCTGAGGGCTCGGCCCCACTGACCCTGGACGATGAGAATTTTGATGTTTGCCCGTGTGCGTGTGTCTCCTG 1441 GGTGTAGTGGATGCCAGTCTTGTTGCTGTGACAAGTAACAACCTTTTTTTTAAATTGTTTTTTATACAAACACTCGCAAT 1521 CCGACATTTGGTGCTAAGGGTTTCCTGGTGCAGACGGTGGGCCTGGGGGCTGGGCTGGACCAGGGCGTGGGTCTCTGGGG 1601 TTGGGGTCCCTTGCTGCTCAGGGAGGCAGTACTGACTGGGCACTGCCTCTGCCCCCAGCACCCACCCTCCCCCATTCCCC 1681 AGGGAGAAGGGGCCCCACTGGGCTTGGCCTGCAGTAGTAGGGAGACAAGTTCCAGGAGCACTTTGGGGACTGGGGTTGCA 1761 GAACACTTCCTGTCTCTGGCTTCATCCTTGGGCCAGAAGGCTCCAACCCTCAGCAGCCCTTGCCAGATGTGCCAGGGAGT 1841 GGGTGTGGAGACCCGGACTCCCCCCACCCACGCACACCTCGGCCTGATGAGAGGATGGAGGCTGGGGCAGAGATGGGCGT 1921 GACCCAGCGTCAGAGGGTCGGGGGAGGCATTCCTTCCTGTGTCCCAGAGCTTCACTGGTGGAGCTGGAGGAGCCGGAGGT 2001 GGAGGGTGGGGTCTGGCAGCTGCTGCTGGGGCAGCCTCATGAGGGGAGGGGAGGGGAGGGGAGGGGAGCAGGCACTGGGC 2081 GGGGGCCTAGGTGCACTTTGTCCTTGCCACCAATGGCGGGAGGAGGGTGGACCTGAACACCTGCAGGGTGTGGTGCCTGC 2161 CCCAGCCTCTCAGGTACTTGGCCCTTGGGGAGAAGAGAAGAGGGTCTGGTTTTTGCTGGGGGTGAGTTTCCGGGACACTC 2241 CCAAAGCCCACAGATAATCCCTGGTGTGGGAAGAGGAGTCCTGGATACCTTGATGTTTAGCACTTTAACCCCCTTTGTCT 2321 TTAAGGTAGGCGTGGGGGCTACTGCCAGAAGTGGCTGTTGGGTCTGACCCCCTCCTTTCTGCCCTCCCTCTGCCACATGC 2401 TGGTCCGCAGAGCCCTCCTCCCAAGGGGTGGGGCCCTGGGTGGAGCTCAGCAGGGTCTGCCCACTCCCTACGCTGGCCCA 2481 CATAGGCCTCCAGGAGCCCTCAGTGAGAGGGACCAGCATAGCTGACCCCCAGAGTGTGGTGGGCGCCGGCCCTGCCCGAG 2561 GCCCAGTCGGGGCCCTTTCTGCAGATCTACCTCTGGCTCAGCGCACGCCCCCTGCCCTGAGAACAGGAAAGGGCCCGGAA 2641 GGGCTGACTCACCGGGCCGACGCTCACACGAAAATGGGATGCACTTTATTTGCTGGTGCAAAGGCAGGTGAGGGTGCCTC 2721 CTGTGTGACCGTTGGCCCTCCTGCCTGGTGGCGCTGAAGGGAAGGAGCCAGTGAGCCTGACCCCGGGAGGGGCCGTCCCC 2801 GTGTGCCGCGTTTGGCGGGGCCCCAGGCGGCTCCCCCAGGCCCGGGTCTGGGGCCCCAGGCTTTCCCCTGCCTCGCGGCC 2881 GGGCGTCCCGTGCTTTGGGTTTCTTGGTTTGGGTTTTTTAATGCCAGTTCTCAGTACATAAGTGCATTTTGAAAGAGGTT 2961 CCAGCTATCACTTGTAACCATATATATATACATATATATTCTATCTACAAAGTGTTTATTTGCGAGATGTTTCAACGGTG 3041 AGTTCGGGCCCCGCCCGCCTTGTGACCATCTGTCCCCGGTCCTCGTCCCCGCCCCGCGCCCTGGTCCCGAGTGGCGTGGG 3121 GACGGGCCATCACTGTATGTATTAAAATGACTGTATCAAATAAATGTTTATTGATTTTTTTCCAAAAAAAAAAAAAAAAA Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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DRVs in gene 3'UTRs | |||||||||||||||||||||
SNPs in gene 3'UTRs |
Experimental Support 1 for Functional miRNA-Target Interaction | |||||||
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miRNA:Target | ---- | ||||||
Validation Method |
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Conditions | HEK293 | ||||||
Disease | 57473.0 | ||||||
Location of target site | 3'UTR | ||||||
Tools used in this research | TargetScan , miRTarCLIP , Piranha | ||||||
Original Description (Extracted from the article) |
...
"PAR-CLIP data was present in GSM714644. RNA binding protein: AGO2. Condition:completeT1
... - Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods. |
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miRNA-target interactions (Provided by authors) |
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Article |
- Kishore S; Jaskiewicz L; Burger L; Hausser et al. - Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
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Experimental Support 2 for Functional miRNA-Target Interaction | |||||||
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miRNA:Target | ---- | ||||||
Validation Method |
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Conditions | HEK293 | ||||||
Disease | 57473.0 | ||||||
Location of target site | 3'UTR | ||||||
Tools used in this research | TargetScan , miRTarCLIP , Piranha | ||||||
Original Description (Extracted from the article) |
...
"PAR-CLIP data was present in GSM1065667. RNA binding protein: AGO1. Condition:4-thiouridine
... - Memczak S; Jens M; Elefsinioti A; Torti F; et al., 2013, Nature. |
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miRNA-target interactions (Provided by authors) |
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Article |
- Memczak S; Jens M; Elefsinioti A; Torti F; et al. - Nature, 2013
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.
LinkOut: [PMID: 23446348]
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CLIP-seq Support 1 for dataset GSM714644 | |
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Method / RBP | PAR-CLIP / AGO2 |
Cell line / Condition | HEK293 / completeT1, repA |
Location of target site | ENST00000369888.1 | 3UTR | UAACCAUAUAUAUAUACAUAUAUAUUCUAUCUACAAAG |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 21572407 / GSE28865 |
CLIP-seq Viewer | Link |
CLIP-seq Support 2 for dataset GSM1065667 | |
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Method / RBP | PAR-CLIP / AGO1 |
Cell line / Condition | HEK293 / 4-thiouridine, ML_MM_6 |
Location of target site | ENST00000369888.1 | 3UTR | UAACCAUAUAUAUAUACAUAUAUAUUCUAUC |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23446348 / GSE43573 |
CLIP-seq Viewer | Link |
MiRNA-Target Expression Profile | |||||||
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MiRNA-Target Expression Profile (TCGA) | |||||||
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62 hsa-miR-758-5p Target Genes:
Functional analysis:
ID![]() |
Target | Description | Validation methods |
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Strong evidence | Less strong evidence | |||||||||||
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MIRT085323 | MORC3 | MORC family CW-type zinc finger 3 | ![]() |
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2 | 2 | ||||||
MIRT089441 | STAMBP | STAM binding protein | ![]() |
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2 | 2 | ||||||
MIRT089456 | TET3 | tet methylcytosine dioxygenase 3 | ![]() |
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2 | 2 | ||||||
MIRT111856 | CCND1 | cyclin D1 | ![]() |
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2 | 2 | ||||||
MIRT184933 | ZNF268 | zinc finger protein 268 | ![]() |
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2 | 2 | ||||||
MIRT215288 | CREBRF | CREB3 regulatory factor | ![]() |
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2 | 2 | ||||||
MIRT237300 | LPP | LIM domain containing preferred translocation partner in lipoma | ![]() |
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2 | 2 | ||||||
MIRT238446 | MYO10 | myosin X | ![]() |
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2 | 4 | ||||||
MIRT273827 | RPL41 | ribosomal protein L41 | ![]() |
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2 | 2 | ||||||
MIRT282703 | HOOK1 | hook microtubule tethering protein 1 | ![]() |
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2 | 2 | ||||||
MIRT347970 | ZNF850 | zinc finger protein 850 | ![]() |
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2 | 2 | ||||||
MIRT371076 | KLF3 | Kruppel like factor 3 | ![]() |
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2 | 2 | ||||||
MIRT464339 | USP6NL | USP6 N-terminal like | ![]() |
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2 | 2 | ||||||
MIRT470034 | PTP4A1 | protein tyrosine phosphatase type IVA, member 1 | ![]() |
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2 | 2 | ||||||
MIRT477506 | ELL2 | elongation factor for RNA polymerase II 2 | ![]() |
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2 | 2 | ||||||
MIRT482886 | CACNA2D3 | calcium voltage-gated channel auxiliary subunit alpha2delta 3 | ![]() |
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2 | 2 | ||||||
MIRT492606 | POLR3E | RNA polymerase III subunit E | ![]() |
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2 | 2 | ||||||
MIRT502294 | GNG12 | G protein subunit gamma 12 | ![]() |
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2 | 6 | ||||||
MIRT507600 | DCTN4 | dynactin subunit 4 | ![]() |
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2 | 4 | ||||||
MIRT510728 | SON | SON DNA binding protein | ![]() |
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2 | 6 | ||||||
MIRT514065 | KCNJ6 | potassium voltage-gated channel subfamily J member 6 | ![]() |
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2 | 8 | ||||||
MIRT519718 | ZNF512B | zinc finger protein 512B | ![]() |
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2 | 4 | ||||||
MIRT520890 | STRN | striatin | ![]() |
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2 | 2 | ||||||
MIRT521760 | PPIL1 | peptidylprolyl isomerase like 1 | ![]() |
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2 | 6 | ||||||
MIRT526874 | ERCC8 | ERCC excision repair 8, CSA ubiquitin ligase complex subunit | ![]() |
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2 | 2 | ||||||
MIRT530232 | WSB2 | WD repeat and SOCS box containing 2 | ![]() |
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2 | 2 | ||||||
MIRT532003 | ACTR2 | ARP2 actin related protein 2 homolog | ![]() |
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2 | 2 | ||||||
MIRT533371 | UBE2D4 | ubiquitin conjugating enzyme E2 D4 (putative) | ![]() |
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2 | 4 | ||||||
MIRT547106 | PIGW | phosphatidylinositol glycan anchor biosynthesis class W | ![]() |
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2 | 2 | ||||||
MIRT548189 | FOXA1 | forkhead box A1 | ![]() |
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2 | 2 | ||||||
MIRT552935 | VKORC1L1 | vitamin K epoxide reductase complex subunit 1 like 1 | ![]() |
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2 | 2 | ||||||
MIRT560085 | ZNF195 | zinc finger protein 195 | ![]() |
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2 | 2 | ||||||
MIRT561726 | PPP2CA | protein phosphatase 2 catalytic subunit alpha | ![]() |
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2 | 2 | ||||||
MIRT562713 | ZNF415 | zinc finger protein 415 | ![]() |
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2 | 2 | ||||||
MIRT562761 | ZNF846 | zinc finger protein 846 | ![]() |
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2 | 2 | ||||||
MIRT564159 | ZNF117 | zinc finger protein 117 | ![]() |
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2 | 2 | ||||||
MIRT565673 | SETD5 | SET domain containing 5 | ![]() |
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2 | 2 | ||||||
MIRT565718 | SESN3 | sestrin 3 | ![]() |
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2 | 2 | ||||||
MIRT566026 | RFX1 | regulatory factor X1 | ![]() |
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2 | 2 | ||||||
MIRT569048 | ZNF655 | zinc finger protein 655 | ![]() |
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2 | 2 | ||||||
MIRT570367 | UBE2V1 | ubiquitin conjugating enzyme E2 V1 | ![]() |
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2 | 2 | ||||||
MIRT570410 | TMEM189-UBE2V1 | TMEM189-UBE2V1 readthrough | ![]() |
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2 | 2 | ||||||
MIRT570443 | TMEM189 | transmembrane protein 189 | ![]() |
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2 | 2 | ||||||
MIRT571738 | RNF11 | ring finger protein 11 | ![]() |
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2 | 2 | ||||||
MIRT575042 | Tpgs2 | tubulin polyglutamylase complex subunit 2 | ![]() |
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2 | 4 | ||||||
MIRT614330 | ZDHHC22 | zinc finger DHHC-type containing 22 | ![]() |
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2 | 2 | ||||||
MIRT617629 | RAB3IP | RAB3A interacting protein | ![]() |
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2 | 2 | ||||||
MIRT621667 | UBE4B | ubiquitination factor E4B | ![]() |
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2 | 2 | ||||||
MIRT639906 | SRGAP2 | SLIT-ROBO Rho GTPase activating protein 2 | ![]() |
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2 | 2 | ||||||
MIRT651436 | XRCC5 | X-ray repair cross complementing 5 | ![]() |
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2 | 2 | ||||||
MIRT683853 | ZNF208 | zinc finger protein 208 | ![]() |
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2 | 2 | ||||||
MIRT684841 | TPGS2 | tubulin polyglutamylase complex subunit 2 | ![]() |
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2 | 5 | ||||||
MIRT689347 | ZNF83 | zinc finger protein 83 | ![]() |
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2 | 2 | ||||||
MIRT692492 | SPIN4 | spindlin family member 4 | ![]() |
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2 | 2 | ||||||
MIRT695711 | OLA1 | Obg like ATPase 1 | ![]() |
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2 | 2 | ||||||
MIRT698219 | TMEM248 | transmembrane protein 248 | ![]() |
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2 | 2 | ||||||
MIRT711560 | FAM20B | FAM20B, glycosaminoglycan xylosylkinase | ![]() |
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2 | 2 | ||||||
MIRT712867 | TMEM67 | transmembrane protein 67 | ![]() |
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2 | 2 | ||||||
MIRT722956 | TSPAN1 | tetraspanin 1 | ![]() |
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2 | 2 | ||||||
MIRT723622 | SOBP | sine oculis binding protein homolog | ![]() |
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2 | 2 | ||||||
MIRT724176 | ABCF2 | ATP binding cassette subfamily F member 2 | ![]() |
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2 | 2 | ||||||
MIRT755363 | LMBR1 | limb development membrane protein 1 | 3 | 1 |
miRNA-Drug Associations | |||||||||||||||||||||||||||||||||||||||||||||
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miRNA-Drug Resistance Associations | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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