pre-miRNA Information | |
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pre-miRNA | hsa-mir-4794 |
Genomic Coordinates | chr1: 64579847 - 64579923 |
Description | Homo sapiens miR-4794 stem-loop |
Comment | None |
RNA Secondary Structure |
Mature miRNA Information | |||||||||||||||||||||||||
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Mature miRNA | hsa-miR-4794 | ||||||||||||||||||||||||
Sequence | 9| UCUGGCUAUCUCACGAGACUGU |30 | ||||||||||||||||||||||||
Evidence | Experimental | ||||||||||||||||||||||||
Experiments | Illumina | ||||||||||||||||||||||||
SNPs in miRNA |
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Putative Targets |
Gene Information | |||||||||||||||||||||
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Gene Symbol | ST13 | ||||||||||||||||||||
Synonyms | AAG2, FAM10A1, FAM10A4, HIP, HOP, HSPABP, HSPABP1, P48, PRO0786, SNC6 | ||||||||||||||||||||
Description | ST13, Hsp70 interacting protein | ||||||||||||||||||||
Transcript | NM_003932 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on ST13 | |||||||||||||||||||||
3'UTR of ST13 (miRNA target sites are highlighted) |
>ST13|NM_003932|3'UTR 1 TGTCCTTCTGATAAATAAAGCCCTTGCTGAAGGAAAAGCAACCTAGATCACCTTATGGATGTCGCAATAATACAAACCAG 81 TGTACCTCTGACCTTCTCATCAAGAGAGCTGGGGTGCTTTGAAGATAATCCCTACCCCTCTCCCCCAAATGCAGCTGAAG 161 CATTTTACAGTGGTTTGCCATTAGGGTATTCATTCAGATAATGTTTTCCTACTAGGAATTACAAACTTTAAACACTTTTT 241 AAATCTTCAAAATATTTAAAACAAATTTAAAGGGCCTGTTAATTCTTATATTTTTCTTTACTAATCATTTTGGATTTTTT 321 TCTTTGAATTATTGGCAGGGAATATACTTATGTATGGAAGATTACTGCTCTGAGTGAAATAAAAGTTATTAGTGCGAGGC 401 AAACATAACTCATTTGAGGATAAAGTTTGTGTTGGATATGTGGTTCCTGATGCATTTTGACTTGTCTTTTTAAATGCTTT 481 ATCTTTTTCTTTAAAGATTTATTTCAATAAAACTAATTGGGACCACCCGTATTTCAGTAGGACCTGGGTAGGGATTGGAA 561 GTACTTGGCAGGGCAGCAGCAATCTTGCTGTGTTTGATATAACATGCATCCTTGGGCAGGTTGCCCTTAAATCTTACACT 641 GTGGTGAAGGGATGTTTTTTTTGTAATGCTGCAGTAGAGTTGGAGTACTTAGTTCTCTTGTTGTCCAGTATATCTAATAA 721 GTGTTTTTCATATTATTTCCACGTAAGGGAAATAAGGTAGTACTTTTCTTTTTATATTTCTATGCTTAAAATTCTCTTTC 801 CTAGTCAAAAATTGCCCAAATCTGTGTTTGCTTTCTGCTTGCTACATTTGTCTCCCTTACTTTTCTTGAGCTAAAGACAG 881 GCTTTTTCCACCGGCATCATCACTGCTATCATCATTAACAGCGTAATTATACAAGCATATTTAATGCTGAGTTTAATTTA 961 ATATGTAATACATATGGTAATTGTAGGGTAATACCCACAACAACTGTAGTTTCTTACTTGGCCAAGAGAATGCTTATTTA 1041 AGTGTTAGACTTCCATTCTGGCAAAATCTTGCCTTATCAGAAGACATTGGAAAGAGGGATTCCCTTTGGTGTTTGGTCTT 1121 CTACTTAGAAAAACCTATTGCAGTTAGTTTATCTTGTAGTATTCATCTTTGTATTCTGAAGATAAGGTTTGAATTAAATT 1201 GATACACACAGAGGGGAACCGATTTTTTTTATCCAATGTGAATTATAAATGAGATAATCCACAGTTATTCATTGTGGAGT 1281 TGTTGAGACTATGAAAGACTCATTGTCTTTGTATTCAGCTCTTAAATAGTGTAACTATATCCCCACCTCTGCTTGCTTTC 1361 TTTCCCTCCCCTCCAATGATAAAGAAAATGATAAATTTTCTGTTGTGCATTCAATTCTTATTTTAAATAAGACTAAGTAT 1441 AGGCATTGTACCTGACATTGCTACGTTTCTACCAGTGTTTCAATTTAAAGTGCTAGTGTTTAAAAACATTTTCAAGGGAT 1521 AAGGCCTTCTGTACTTTGCTTATTTGAAGAATCAGTGGTAGGAGCAGTGAAGTAAATTCTATGGAGTACATTTCTAAAAT 1601 ACCACATTTCTGAAATCATAAATAAGTTTATTCAGGTTCTAACCCTTTGCTGTACACAAGCAGACAGAAATGCATCTGTT 1681 ACATAAATGAGAAAAAGCTATTATGCTGATGGAGCATGCTTTTTAAATCCTTTAAAAACACTCACCATATAAACTTGCAT 1761 TTGAGCTTGTGTGTTCTTTTGTTAATGTGTAGAGTTCTCCTTTCTCGAAATTGCCAGTGTGTACTTGGCTTAACTCAAGA 1841 ACAGTTTCTTCTGGATTCCTTATTTGATTTATTTAACCTAATTATATTCTAATATTGCAAATATTACCATAAGTGGGTAA 1921 AAGTAAAATTCCTCTTCTGAAAATGTGTCCTGTGCTTTTAGATTTTTAAATTCCATAATATACATTCTTAATTTTCAACT 2001 CAAAAAAAAAAAAAAAAAA Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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DRVs in gene 3'UTRs | |||||||||||||||||||||
SNPs in gene 3'UTRs |
Experimental Support 1 for Functional miRNA-Target Interaction | |||||||
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miRNA:Target | ---- | ||||||
Validation Method |
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Conditions | HEK293 | ||||||
Disease | 6767.0 | ||||||
Location of target site | 3'UTR | ||||||
Tools used in this research | TargetScan , miRTarCLIP , Piranha | ||||||
Original Description (Extracted from the article) |
...
"PAR-CLIP data was present in GSM1065667. RNA binding protein: AGO1. Condition:4-thiouridine
... - Memczak S; Jens M; Elefsinioti A; Torti F; et al., 2013, Nature. |
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miRNA-target interactions (Provided by authors) |
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Article |
- Memczak S; Jens M; Elefsinioti A; Torti F; et al. - Nature, 2013
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.
LinkOut: [PMID: 23446348]
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CLIP-seq Support 1 for dataset GSM1065667 | |
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Method / RBP | PAR-CLIP / AGO1 |
Cell line / Condition | HEK293 / 4-thiouridine, ML_MM_6 |
Location of target site | ENST00000216218.3 | 3UTR | CUACUAAAAAUACAAAAACUAGCCAGGCAUG |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23446348 / GSE43573 |
CLIP-seq Viewer | Link |
MiRNA-Target Expression Profile | |||||||
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MiRNA-Target Expression Profile (TCGA) | |||||||
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110 hsa-miR-4794 Target Genes:
Functional analysis:
ID | Target | Description | Validation methods | |||||||||
Strong evidence | Less strong evidence | |||||||||||
MIRT059821 | EFNA1 | ephrin A1 | 2 | 2 | ||||||||
MIRT203153 | BACH1 | BTB domain and CNC homolog 1 | 2 | 2 | ||||||||
MIRT334253 | SERPINH1 | serpin family H member 1 | 2 | 2 | ||||||||
MIRT475239 | IGF2BP3 | insulin like growth factor 2 mRNA binding protein 3 | 2 | 2 | ||||||||
MIRT482467 | ADAR | adenosine deaminase, RNA specific | 2 | 4 | ||||||||
MIRT482632 | AAR2 | AAR2 splicing factor homolog | 2 | 2 | ||||||||
MIRT511147 | MRPL17 | mitochondrial ribosomal protein L17 | 2 | 4 | ||||||||
MIRT514416 | RSL1D1 | ribosomal L1 domain containing 1 | 2 | 2 | ||||||||
MIRT514842 | LYRM7 | LYR motif containing 7 | 2 | 4 | ||||||||
MIRT515343 | CXorf36 | chromosome X open reading frame 36 | 2 | 2 | ||||||||
MIRT515806 | ALOX5AP | arachidonate 5-lipoxygenase activating protein | 2 | 2 | ||||||||
MIRT516396 | NPR1 | natriuretic peptide receptor 1 | 2 | 4 | ||||||||
MIRT516622 | DARS2 | aspartyl-tRNA synthetase 2, mitochondrial | 2 | 2 | ||||||||
MIRT516959 | SLC35F6 | solute carrier family 35 member F6 | 2 | 2 | ||||||||
MIRT517154 | VHLL | VHL like | 2 | 2 | ||||||||
MIRT517268 | NRIP2 | nuclear receptor interacting protein 2 | 2 | 2 | ||||||||
MIRT517660 | TRIM72 | tripartite motif containing 72 | 2 | 4 | ||||||||
MIRT518026 | ABHD15 | abhydrolase domain containing 15 | 2 | 2 | ||||||||
MIRT518116 | RNMTL1 | mitochondrial rRNA methyltransferase 3 | 2 | 4 | ||||||||
MIRT518143 | C15orf40 | chromosome 15 open reading frame 40 | 2 | 4 | ||||||||
MIRT518232 | C7orf55 | formation of mitochondrial complex V assembly factor 1 homolog | 2 | 2 | ||||||||
MIRT518517 | CASP10 | caspase 10 | 2 | 2 | ||||||||
MIRT518646 | NOM1 | nucleolar protein with MIF4G domain 1 | 2 | 2 | ||||||||
MIRT519287 | SPCS1 | signal peptidase complex subunit 1 | 2 | 2 | ||||||||
MIRT519487 | PNPLA3 | patatin like phospholipase domain containing 3 | 2 | 2 | ||||||||
MIRT520917 | ST13 | ST13, Hsp70 interacting protein | 2 | 2 | ||||||||
MIRT520928 | SSBP2 | single stranded DNA binding protein 2 | 2 | 2 | ||||||||
MIRT521966 | PHAX | phosphorylated adaptor for RNA export | 2 | 4 | ||||||||
MIRT522244 | NPFFR1 | neuropeptide FF receptor 1 | 2 | 2 | ||||||||
MIRT523355 | GTF3C6 | general transcription factor IIIC subunit 6 | 2 | 2 | ||||||||
MIRT525181 | ZNF468 | zinc finger protein 468 | 2 | 2 | ||||||||
MIRT528221 | METTL8 | methyltransferase like 8 | 2 | 2 | ||||||||
MIRT528437 | COL9A2 | collagen type IX alpha 2 chain | 2 | 2 | ||||||||
MIRT531504 | NONO | non-POU domain containing octamer binding | 2 | 2 | ||||||||
MIRT532597 | SIX4 | SIX homeobox 4 | 2 | 2 | ||||||||
MIRT532761 | LDHD | lactate dehydrogenase D | 2 | 2 | ||||||||
MIRT536012 | MECP2 | methyl-CpG binding protein 2 | 2 | 2 | ||||||||
MIRT536262 | LPGAT1 | lysophosphatidylglycerol acyltransferase 1 | 2 | 2 | ||||||||
MIRT547555 | LRRC58 | leucine rich repeat containing 58 | 2 | 2 | ||||||||
MIRT554691 | RNF2 | ring finger protein 2 | 2 | 2 | ||||||||
MIRT557250 | CRAMP1L | cramped chromatin regulator homolog 1 | 2 | 2 | ||||||||
MIRT563339 | RPLP0 | ribosomal protein lateral stalk subunit P0 | 2 | 2 | ||||||||
MIRT573179 | P2RX3 | purinergic receptor P2X 3 | 2 | 2 | ||||||||
MIRT574386 | UBE2N | ubiquitin conjugating enzyme E2 N | 2 | 2 | ||||||||
MIRT574638 | LPCAT3 | lysophosphatidylcholine acyltransferase 3 | 2 | 2 | ||||||||
MIRT609143 | ZNF610 | zinc finger protein 610 | 2 | 4 | ||||||||
MIRT609651 | PACS2 | phosphofurin acidic cluster sorting protein 2 | 2 | 2 | ||||||||
MIRT610846 | ZNF44 | zinc finger protein 44 | 2 | 2 | ||||||||
MIRT612345 | TP53INP1 | tumor protein p53 inducible nuclear protein 1 | 2 | 2 | ||||||||
MIRT613002 | GATA6 | GATA binding protein 6 | 2 | 2 | ||||||||
MIRT614095 | PDE4C | phosphodiesterase 4C | 2 | 2 | ||||||||
MIRT615512 | AGTRAP | angiotensin II receptor associated protein | 2 | 2 | ||||||||
MIRT621281 | PIWIL1 | piwi like RNA-mediated gene silencing 1 | 2 | 2 | ||||||||
MIRT623367 | LUC7L2 | LUC7 like 2, pre-mRNA splicing factor | 2 | 2 | ||||||||
MIRT624508 | C7orf55-LUC7L2 | C7orf55-LUC7L2 readthrough | 2 | 2 | ||||||||
MIRT632570 | POLQ | DNA polymerase theta | 2 | 2 | ||||||||
MIRT634829 | ARHGEF39 | Rho guanine nucleotide exchange factor 39 | 2 | 2 | ||||||||
MIRT639452 | CTNNBL1 | catenin beta like 1 | 2 | 2 | ||||||||
MIRT642097 | FBXL2 | F-box and leucine rich repeat protein 2 | 2 | 2 | ||||||||
MIRT648408 | TRMT10B | tRNA methyltransferase 10B | 2 | 2 | ||||||||
MIRT653936 | SERPINC1 | serpin family C member 1 | 2 | 2 | ||||||||
MIRT658226 | FBXL16 | F-box and leucine rich repeat protein 16 | 2 | 2 | ||||||||
MIRT662599 | MAGEB4 | MAGE family member B4 | 2 | 2 | ||||||||
MIRT663190 | IBA57 | IBA57 homolog, iron-sulfur cluster assembly | 2 | 2 | ||||||||
MIRT664623 | DNPEP | aspartyl aminopeptidase | 2 | 2 | ||||||||
MIRT671879 | ZNF429 | zinc finger protein 429 | 2 | 2 | ||||||||
MIRT679033 | ZNF419 | zinc finger protein 419 | 2 | 2 | ||||||||
MIRT684892 | ZSCAN22 | zinc finger and SCAN domain containing 22 | 2 | 2 | ||||||||
MIRT685153 | DTWD2 | DTW domain containing 2 | 2 | 2 | ||||||||
MIRT686415 | TVP23C | trans-golgi network vesicle protein 23 homolog C | 2 | 2 | ||||||||
MIRT687021 | RNF24 | ring finger protein 24 | 2 | 2 | ||||||||
MIRT688369 | ENPP1 | ectonucleotide pyrophosphatase/phosphodiesterase 1 | 2 | 2 | ||||||||
MIRT689600 | FAM96A | family with sequence similarity 96 member A | 2 | 2 | ||||||||
MIRT690375 | ZSWIM7 | zinc finger SWIM-type containing 7 | 2 | 2 | ||||||||
MIRT690484 | RSRC1 | arginine and serine rich coiled-coil 1 | 2 | 2 | ||||||||
MIRT691458 | C21orf58 | chromosome 21 open reading frame 58 | 2 | 2 | ||||||||
MIRT691861 | ZNF552 | zinc finger protein 552 | 2 | 2 | ||||||||
MIRT692035 | ARSK | arylsulfatase family member K | 2 | 2 | ||||||||
MIRT693951 | HNRNPA1L2 | heterogeneous nuclear ribonucleoprotein A1-like 2 | 2 | 2 | ||||||||
MIRT694058 | NQO2 | N-ribosyldihydronicotinamide:quinone reductase 2 | 2 | 2 | ||||||||
MIRT694469 | LRTOMT | leucine rich transmembrane and O-methyltransferase domain containing | 2 | 2 | ||||||||
MIRT695028 | ALG10B | ALG10B, alpha-1,2-glucosyltransferase | 2 | 2 | ||||||||
MIRT695093 | CHRNB1 | cholinergic receptor nicotinic beta 1 subunit | 2 | 2 | ||||||||
MIRT696624 | WDR77 | WD repeat domain 77 | 2 | 2 | ||||||||
MIRT697446 | ZCCHC8 | zinc finger CCHC-type containing 8 | 2 | 2 | ||||||||
MIRT697871 | UBE2D3 | ubiquitin conjugating enzyme E2 D3 | 2 | 2 | ||||||||
MIRT700637 | PQLC2 | PQ loop repeat containing 2 | 2 | 2 | ||||||||
MIRT701192 | OTUD3 | OTU deubiquitinase 3 | 2 | 2 | ||||||||
MIRT701332 | NSD1 | nuclear receptor binding SET domain protein 1 | 2 | 2 | ||||||||
MIRT702199 | LPP | LIM domain containing preferred translocation partner in lipoma | 2 | 2 | ||||||||
MIRT702891 | HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 2 | 2 | ||||||||
MIRT704389 | CTSS | cathepsin S | 2 | 2 | ||||||||
MIRT704922 | CCDC36 | coiled-coil domain containing 36 | 2 | 2 | ||||||||
MIRT705770 | ALG14 | ALG14, UDP-N-acetylglucosaminyltransferase subunit | 2 | 2 | ||||||||
MIRT705797 | ALDH6A1 | aldehyde dehydrogenase 6 family member A1 | 2 | 2 | ||||||||
MIRT705874 | AEN | apoptosis enhancing nuclease | 2 | 2 | ||||||||
MIRT707372 | ORAI2 | ORAI calcium release-activated calcium modulator 2 | 2 | 2 | ||||||||
MIRT707426 | RRP7A | ribosomal RNA processing 7 homolog A | 2 | 2 | ||||||||
MIRT710293 | SPN | sialophorin | 2 | 2 | ||||||||
MIRT710744 | ZNF71 | zinc finger protein 71 | 2 | 2 | ||||||||
MIRT713183 | ERO1L | endoplasmic reticulum oxidoreductase 1 alpha | 1 | 1 | ||||||||
MIRT715030 | RANBP6 | RAN binding protein 6 | 2 | 2 | ||||||||
MIRT715829 | ZNF598 | zinc finger protein 598 | 2 | 2 | ||||||||
MIRT720340 | BACE2 | beta-site APP-cleaving enzyme 2 | 2 | 2 | ||||||||
MIRT722662 | VKORC1L1 | vitamin K epoxide reductase complex subunit 1 like 1 | 2 | 2 | ||||||||
MIRT722683 | RRM2 | ribonucleotide reductase regulatory subunit M2 | 2 | 2 | ||||||||
MIRT723908 | PEX11A | peroxisomal biogenesis factor 11 alpha | 2 | 2 | ||||||||
MIRT724044 | SMIM14 | small integral membrane protein 14 | 2 | 2 | ||||||||
MIRT725241 | PDE1B | phosphodiesterase 1B | 2 | 2 | ||||||||
MIRT725307 | NLRC5 | NLR family CARD domain containing 5 | 2 | 2 |
miRNA-Drug Associations | ||||||||||||||||||
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miRNA-Drug Resistance Associations | ||||||||||||||||||||||||||||||||||||||||||||||||||
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