pre-miRNA Information | |
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pre-miRNA | hsa-mir-1268a |
Genomic Coordinates | chr15: 22225278 - 22225329 |
Description | Homo sapiens miR-1268a stem-loop |
Comment | None |
RNA Secondary Structure |
Mature miRNA Information | |||||||||||||||||||||||||||||||||||||
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Mature miRNA | hsa-miR-1268a | ||||||||||||||||||||||||||||||||||||
Sequence | 5| CGGGCGUGGUGGUGGGGG |22 | ||||||||||||||||||||||||||||||||||||
Evidence | Experimental | ||||||||||||||||||||||||||||||||||||
Experiments | Illumina | ||||||||||||||||||||||||||||||||||||
SNPs in miRNA |
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Putative Targets |
miRNA Expression profile | |
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Human miRNA Tissue Atlas | |
miRNAs in Extracellular Vesicles |
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Circulating MicroRNA Expression Profiling |
Gene Information | |||||||||||||||||||||
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Gene Symbol | SGPL1 | ||||||||||||||||||||
Synonyms | NPHS14, S1PL, SPL | ||||||||||||||||||||
Description | sphingosine-1-phosphate lyase 1 | ||||||||||||||||||||
Transcript | NM_003901 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on SGPL1 | |||||||||||||||||||||
3'UTR of SGPL1 (miRNA target sites are highlighted) |
>SGPL1|NM_003901|3'UTR 1 ACTTGGACCCTTTCTAGTCTCAAGGGGATTCCAGCCTTCAGAAGGTTCTTGGGATATGGAACAGGCCGTGCACAACTTTG 81 ACATCTGGTCTTGCTCCATAGAGCACAACTCAAGATAGACCATGAGACAGCTTGAGCCTCAGGATTCTTGTTCTTCCTCT 161 TATCTTCCTTTTGTGGTTTTTAATTTGAAGACCCCAGAGAATTCCATTACATAATGATTTTGCCCTTGTTATAAATGTTA 241 CCCTAGGAATTGTTTTAACCATTTCCTTTTCTAAACTCTCTAGCTTTCAACTTTACTTAAACATTGTGTGGTAGCTCTGA 321 CCTGTCCTGATTCTTTAGAGAAGCTGGGGTACAGTTTATGAGATAGCTAGAGCTTCTTTGTTATCTCAGGCAGGAGGCGT 401 TTACATAACAGATGTTTCCTCAGCTGGGTGTGAGGTATACTCTAAGCAGGAGGCTTTTTCAGCCTTCTCTCTCTTTTTTT 481 TTTTTTTTTTTTTTTTTGAGATGGAATTTTGCTCTTTTGCCCAGTCTGGAGTGCAGTGGCATGATCTCAGCTCACTGCAA 561 CCTCCACCCACTGGGTTCAAGCGATTCTTCTGCCTCAGCCTCCCGAGTAGCTGGGATTACCGGCACCCACCACCACGCCT 641 GGCTAATTTTTCAATTTTCTTTTTCAGTAGAGACGGGTTCACCGTGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGG 721 TGATACCCGCCCCCCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGTGCCTGGCCCTGTCTCTCTT 801 AAGAGTAGGTTCATTGTCTGTCTTAGAGTCACTTCTATTGCAACTCATTTTCTTTTTCCAGGGCACAGATCGACCAAGCT 881 GCCGTTCCCTATTCTGCAGGACAGGACTATTCTAGCATACCTGCTTCGTCCACCCAGGCAGGGTTTGGGGTGGTCTCTTC 961 TGTGCCTGCAGTCCCCATTTGACACTTGGTTGCCACCATCTTTGGAGATTATTGTTTGGAATGATGCTTCCATTGGCTTT 1041 TTCTTGTTACCATGGACTAGGAAGAAAACATGGTTTCCAAATAATCTGGGAGCTTTTGGCCATGGTGCCGCCTTCCTGAA 1121 TTGGCAGTGGTCAGAGCACACCTGAACCCTATCCTGGGCTGGTGATGAGCAGAAATCAGACCTTTTTCTATGCTTTTTTG 1201 AATATCAGAGTAGGATGAACACCCAGATTCAAATATGTCACCAAAGTTGGTGGTGGTCCTTCCCTGCACCCTTGCGTTAA 1281 GCCATTATGTAATGAAAATGTGTTTGCTTGAAGGAACAGCTCAAAGCACCTTCACAAGTTGCCTTGACTTACCCTAGGTG 1361 GGTGTGAAAGAGCACCCGTAGCAAGGAAAATTTTCTCTATTAGTGTGTTCTTCTGCCTCTTCCCCCTTGATTCAGCTTTC 1441 AGAGGTACTATGGCAGTTTTGCCTCAGGTGCTGAACATTTCTCAGCCCTGGCTAAAAGGGAGCAGCACAGGGAGAGAAAC 1521 AGGATAGGAAAGCAGAATGGCGAGCAGCCTATGGCCCAGGGCCTGTAATCCCTTCCCAAGACTAGCTGCTCAGGGTGGTG 1601 CAGGGACAGGACCAGACCCTGCGCCTATTTCCTGCCTTCTTTCCCCTATAGGGAACTCTGTAGGCTGAGCCACTGTCCTG 1681 CTCTTATGACATTATATCTTGTGCCTTTCTCCTCAGCAGTGAGCAGTGAGCTACTCCTGGCCCAGGCCCTAGGGGAAATG 1761 GATCAGTCTTTGAGGTTTCTATTTGGGGAGGGGAGTACTTAAGATGAGTCAAAAGACACTTTCCTCTGTTCCATTCCCCA 1841 TCTCAGGGACTCCTGAATATTCAGCCTCTCCAGGCTGGTGTCTTCTAGTTTCCCCCACTGGGAATGCTGGCTGGGAGAGC 1921 CATGACTACCAGACTTTTCCTCAGGCTCCTTGGCATGTTAGTCTGAATTGTTCTTGAGCACTGTACTACTGACCCAACAA 2001 CTGTGACTAGCTGGCCACGCCATTCAGGGCTGGTGTGGCATTTATGTGTGTGTGTGTGTGTGTGTGTGTTTTTCCTGTTT 2081 GCCCAGCAGTGCATTGTGGGTTCCAAGAGTGGGTAGTGTGTGTATGTGTGTGTGTCAGAGGGAGACCTGGCAGGCACCTC 2161 TTTGAGAGTAGCTGTGGTCAGAGCTGTTTGGTCAGTGCATTATGTTGAATGAGGTCCAGGAACCCAGAGCCACCCAGCAG 2241 ACACCACTGTGGCTTGCCAGCTGCCAAGATGGAGAAGCATGTGCCCCTGTAGAGCGTCTCCCCAGAACCAGACCCCGAGC 2321 CACTCGCTTCCTCTGTGCTGTGACAACATTGGTGCCAGGGGAGATGGTGTTTTTCAAAGGGACCTACTGTAGCCACTTTA 2401 ATTTACAATTAAGAGCCTTAGTTTGACTTAACACTTTTGTAGGCTTTTCATTGTGTATTTTTGTGTATGTGTGCATATAG 2481 CAGCTACTCTGTAGCAGAGGTGGGTAGAGACACTTAATAGTATCATGTCGCATGCAGATGTCACATCGGCCTCTGCAAAA 2561 ACTGTACTGTCTTGTTTCTGCATTAGACTTAAGTAGTCATGTGAATATACTGCTATGTCACTTTTAATATTACGAGTTTT 2641 ATACTTGGAAAATGGTACTTGCTTCTTTTAAATCTCTGTCTTCTCTAACCTCCCCCTTCCCATTTCAATGCTCCCTTCCT 2721 AATTTCAGCAATAATCTCAAAAAGCAATTAAATAGTTAAATGACCCTAATTGTAATTACTGTGGATGGTTGCATTCATTT 2801 GATTACTTGGGCACACACGAGATGACAAATGGGGCAGTGGCCATGCTTGAATGGGCTCCTGGTGAGAGATTGCCCCCTGG 2881 TGGTGAAACAATCGTGTGTGCCCACTGATACCAAGACCAATGAAAGAGACACAGTTAAGCAGCAATCCATCTCATTTCCA 2961 GGCACTTCAATAGGTCGCTGATTGGTCCTTGCACCAGCAGTGGTAGTCGTACCTATTTCAGAGAGGTCTGAAATTCAGGT 3041 TCTTAGTTTGCCAGGGACAGGCCCTATCTTATATTTTTTTCCATCTTCATCATCCACTTCTGCTTACAGTTTGCTGCTTA 3121 CAATAACTTAATGATGGATTGAGTTATCTGGGTGGTCTCTAGCCATCTGGGCAGTGTGGTTCTGTCTAACCAAAGGGCAT 3201 TGGCCTCAAACCCTGCATTTGGTTTAGGGGCTAACAGAGCTCCTCAGATAATCTTCACACACATGTAACTGCTGGAGATC 3281 TTATTCTATTATGAATAAGAAACGAGAAGTTTTTCCAAAGTGTTAGTCAGGATCTGAAGGCTGTCATTCAGATAACCCAG 3361 CTTTTCCTTTTGGCTTTTAGCCCATTCAGACTTTGCCAGAGTCAAGCCAAGGATTGCTTTTTTGCTACAGTTTTCTGCCA 3441 AATGGCCTAGTTCCTGAGTACCTGGAAACCAGAGAGAAAGAGGATCCAGGATGTACTTGGATGAGGAGGCCTGGCTTATC 3521 TAGGAAGTCGTGTCTGGGGTGCTTATTGCTGCTCCATACAGCTGTACGTCAGCCCCTTGGCCTTCTCTGTAGGTTCTTGG 3601 CAGCAATGAGCAGCTTTCACTCAGTGACACAAGTAATTACTGAGTCCTAATTTGATAGCCACCAACTGTACCTGGGTAGG 3681 CAAAGTCAGATTTTTGAGAACCTTTTTCCTGATTTGAAGTTTTAATTACCTTATTTTCTTTTATGCTTTCCTCTGTCTTG 3761 TAATCTTTTCTCTTCTTAATATCCTTCCCTATAATTTCAATTATTTGGATTAATTTTAGAATAAACCTATTTATTTCTAA 3841 AAAAAAAAAGAAAA Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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DRVs in gene 3'UTRs | |||||||||||||||||||||
SNPs in gene 3'UTRs |
Experimental Support 1 for Functional miRNA-Target Interaction | |||||||
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miRNA:Target | ---- | ||||||
Validation Method |
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Conditions | HEK293 | ||||||
Location of target site | 3'UTR | ||||||
Tools used in this research | TargetScan , miRTarCLIP , Piranha | ||||||
Original Description (Extracted from the article) |
...
PAR-CLIP data was present in GSM545217. RNA binding protein: AGO2. Condition:miR-7 transfection
... - Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell. |
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miRNA-target interactions (Provided by authors) |
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Article |
- Hafner M; Landthaler M; Burger L; Khorshid et al. - Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
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Experimental Support 2 for Functional miRNA-Target Interaction | |||||||
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miRNA:Target | ---- | ||||||
Validation Method |
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Conditions | HEK293 | ||||||
Disease | 8879.0 | ||||||
Location of target site | 3'UTR | ||||||
Tools used in this research | TargetScan , miRTarCLIP , Piranha | ||||||
Original Description (Extracted from the article) |
...
"PAR-CLIP data was present in GSM1065667. RNA binding protein: AGO1. Condition:4-thiouridine
... - Memczak S; Jens M; Elefsinioti A; Torti F; et al., 2013, Nature. |
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miRNA-target interactions (Provided by authors) |
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Article |
- Memczak S; Jens M; Elefsinioti A; Torti F; et al. - Nature, 2013
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.
LinkOut: [PMID: 23446348]
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CLIP-seq Support 1 for dataset GSM545217 | |
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Method / RBP | PAR-CLIP / AGO2 |
Cell line / Condition | HEK293 / miR-7 transfection |
Location of target site | ENST00000373202.3 | 3UTR | UUACCGGCACCCACCA |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 20371350 / GSE21578 |
CLIP-seq Viewer | Link |
CLIP-seq Support 2 for dataset GSM1065667 | |
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Method / RBP | PAR-CLIP / AGO1 |
Cell line / Condition | HEK293 / 4-thiouridine, ML_MM_6 |
Location of target site | ENST00000373202.3 | 3UTR | GAUUACCGGCACCCACCA |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23446348 / GSE43573 |
CLIP-seq Viewer | Link |
MiRNA-Target Expression Profile | |||||||
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MiRNA-Target Expression Profile (TCGA) | |||||||
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44 hsa-miR-1268a Target Genes:
Functional analysis:
ID | Target | Description | Validation methods | |||||||||
Strong evidence | Less strong evidence | |||||||||||
MIRT035845 | POLR2I | RNA polymerase II subunit I | 1 | 1 | ||||||||
MIRT035847 | FASN | fatty acid synthase | 1 | 1 | ||||||||
MIRT053736 | SOX12 | SRY-box 12 | 1 | 1 | ||||||||
MIRT053737 | CAMK2G | calcium/calmodulin dependent protein kinase II gamma | 1 | 1 | ||||||||
MIRT473717 | MAPK1 | mitogen-activated protein kinase 1 | 2 | 2 | ||||||||
MIRT483654 | QSOX2 | quiescin sulfhydryl oxidase 2 | 2 | 4 | ||||||||
MIRT484277 | AIP | aryl hydrocarbon receptor interacting protein | 2 | 4 | ||||||||
MIRT486674 | WDR81 | WD repeat domain 81 | 2 | 2 | ||||||||
MIRT488672 | WWP2 | WW domain containing E3 ubiquitin protein ligase 2 | 2 | 4 | ||||||||
MIRT493453 | ITFG3 | family with sequence similarity 234 member A | 2 | 2 | ||||||||
MIRT495902 | ZNF641 | zinc finger protein 641 | 2 | 2 | ||||||||
MIRT500188 | BARX1 | BARX homeobox 1 | 2 | 4 | ||||||||
MIRT512015 | DNAJC10 | DnaJ heat shock protein family (Hsp40) member C10 | 2 | 2 | ||||||||
MIRT521134 | SGPL1 | sphingosine-1-phosphate lyase 1 | 2 | 4 | ||||||||
MIRT530047 | TRIM72 | tripartite motif containing 72 | 2 | 2 | ||||||||
MIRT531519 | NOM1 | nucleolar protein with MIF4G domain 1 | 2 | 2 | ||||||||
MIRT543736 | DHCR7 | 7-dehydrocholesterol reductase | 2 | 2 | ||||||||
MIRT558054 | EVI5L | ecotropic viral integration site 5 like | 2 | 2 | ||||||||
MIRT569603 | TRIM29 | tripartite motif containing 29 | 2 | 2 | ||||||||
MIRT570027 | FAM228A | family with sequence similarity 228 member A | 2 | 2 | ||||||||
MIRT573595 | CERS1 | ceramide synthase 1 | 2 | 2 | ||||||||
MIRT623884 | FRMPD4 | FERM and PDZ domain containing 4 | 2 | 2 | ||||||||
MIRT630000 | PDE6B | phosphodiesterase 6B | 2 | 2 | ||||||||
MIRT632716 | MSANTD4 | Myb/SANT DNA binding domain containing 4 with coiled-coils | 2 | 2 | ||||||||
MIRT633497 | ERO1L | endoplasmic reticulum oxidoreductase 1 alpha | 1 | 1 | ||||||||
MIRT637076 | SELPLG | selectin P ligand | 2 | 2 | ||||||||
MIRT638183 | TLN1 | talin 1 | 2 | 2 | ||||||||
MIRT638767 | EPB41 | erythrocyte membrane protein band 4.1 | 2 | 2 | ||||||||
MIRT668073 | GMPS | guanine monophosphate synthase | 2 | 2 | ||||||||
MIRT669874 | RAET1E | retinoic acid early transcript 1E | 2 | 2 | ||||||||
MIRT670664 | KIAA1551 | KIAA1551 | 2 | 2 | ||||||||
MIRT671283 | RPL37A | ribosomal protein L37a | 2 | 2 | ||||||||
MIRT675055 | OR7D2 | olfactory receptor family 7 subfamily D member 2 | 2 | 2 | ||||||||
MIRT682784 | BLOC1S3 | biogenesis of lysosomal organelles complex 1 subunit 3 | 2 | 2 | ||||||||
MIRT683344 | SCARF1 | scavenger receptor class F member 1 | 2 | 2 | ||||||||
MIRT690283 | ZNF154 | zinc finger protein 154 | 2 | 2 | ||||||||
MIRT695172 | SLC25A33 | solute carrier family 25 member 33 | 2 | 2 | ||||||||
MIRT695222 | SCAMP3 | secretory carrier membrane protein 3 | 2 | 2 | ||||||||
MIRT700485 | PTPRF | protein tyrosine phosphatase, receptor type F | 2 | 2 | ||||||||
MIRT700601 | PRKCA | protein kinase C alpha | 2 | 2 | ||||||||
MIRT701410 | NKRF | NFKB repressing factor | 2 | 2 | ||||||||
MIRT703995 | EIF5A2 | eukaryotic translation initiation factor 5A2 | 2 | 2 | ||||||||
MIRT711232 | RETSAT | retinol saturase | 2 | 2 | ||||||||
MIRT719510 | TMEM175 | transmembrane protein 175 | 2 | 2 |
miRNA-Drug Associations | ||||||||||||||||||
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miRNA-Drug Resistance Associations | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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