pre-miRNA Information
pre-miRNA hsa-mir-758   
Genomic Coordinates chr14: 101026020 - 101026107
Synonyms MIRN758, hsa-mir-758, MIR758
Description Homo sapiens miR-758 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-758-5p
Sequence 15| GAUGGUUGACCAGAGAGCACAC |36
Evidence Experimental
Experiments SOLiD
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 16 14 + 101026049 29233923 MiREDiBase
A-to-I 21 14 + 101026054 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs372417522 1 dbSNP
rs748092616 2 dbSNP
rs1270901332 4 dbSNP
rs1364206491 5 dbSNP
rs1483583954 8 dbSNP
rs770931807 10 dbSNP
rs776760808 11 dbSNP
rs1360350664 12 dbSNP
rs759742151 13 dbSNP
rs1002938972 15 dbSNP
rs770107042 17 dbSNP
rs369242818 20 dbSNP
rs1217090272 21 dbSNP
rs763341052 22 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol PPIL1   
Synonyms CGI-124, CYPL1, PPIase, hCyPX
Description peptidylprolyl isomerase like 1
Transcript NM_016059   
Expression
Putative miRNA Targets on PPIL1
3'UTR of PPIL1
(miRNA target sites are highlighted)
>PPIL1|NM_016059|3'UTR
   1 ACTTGCTACCCTCTTGAGCAGCTCTTCTGAGATGGCCCCAGTGAACCAGCTTCTAGATGACATAGAATGACATGTAATGC
  81 TAAATTCATTTTGGCTTTGCAAGTCATGAAGCTTAGGAGGCCTGGCATCTTGGGTGAGTTAGAGATGGAAGTACATTTTA
 161 ATAGGATGCTTCTTTTCTCTTCCCCCAGTGCCTAGGTTGCCAGAGCATTTGCACAAATGCCCCTGTTTATCAATAGGTGA
 241 CTACTTACTACACATGAACCATAATGCTGCTTCTTGTGCATGTCTGCTCTGATATACGTCGAACAATGTAGCAGCCACTG
 321 TCATTTCTCAGTGGTTTTGCCTAACCAAACTTCTTCCTAAGGAGATTTATATTCTGGCCTACACAGCAGTCCTTGATGGC
 401 TGACAGCCACAGAATTCCAAACCAAGTAGTGTCTGTCAGCCCTCTTAACTCTGTGCACGCCCTATTTCAGTCTTTTACAT
 481 TTGTTCTTCTAGGGAATGTATGCATCTCTATATATATTTTCCCTCTCAAAACCAGAACATCAACAGTGCTGTTTCTGACA
 561 CTTCAGACATCCCACGCAAAGCCACATTGAATTTTTGCCAAATGAAAAACACATCCAACAATCAAGTTTCTAAGAAGGTG
 641 TCAAGTGGGGAATAATAATAATGTATAATAATCAAGAAATTAGTTTATTAAAAGGAAGCAGAAGCATTGACCATTTTTTC
 721 CCAGAGAAGAGGAGAAATCTGTAGTGAGCAAAGGACAGACCATGAATCCTCCTTGAGAAGTAGTACTCTCAGAAAGGAGA
 801 AGCGCCACTCAAGTTCTTTTAACCCAAGACTTTAGAGAAATTAGGTCCAAGATTTTTATATGTTCAGTTGTTTATGTATA
 881 AAAATAACTTTCTGGATTTTGTGGGGAGGAGCAGGAGAGGAAGGAAGTTAATACCTATGTAATACATAGAAACTTCCACA
 961 ATAAAATGCCATTGATGGTTGAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' caCACGAGAGACCAGUUGGUag 5'
            ||| | |:||  :|||||  
Target 5' caGTGGT-TTTGCCTAACCAaa 3'
329 - 349 123.00 -11.70
2
miRNA  3' cacacgagagaccagUUGGUAg 5'
                         |||||| 
Target 5' tacttactacacatgAACCATa 3'
242 - 263 120.00 -6.10
3
miRNA  3' caCACGAGAGACCAGU-UGGUAg 5'
            |||  |   || || ||||| 
Target 5' taGTGAGCAAAGGACAGACCATg 3'
742 - 764 120.00 -9.30
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN26505833 10 COSMIC
COSN31548664 14 COSMIC
COSN26990033 44 COSMIC
COSN30526029 65 COSMIC
COSN20102784 84 COSMIC
COSN31508574 94 COSMIC
COSN31491800 100 COSMIC
COSN31563939 121 COSMIC
COSN30161257 129 COSMIC
COSN7871773 327 COSMIC
COSN30202436 389 COSMIC
COSN31543015 451 COSMIC
COSN29962444 458 COSMIC
COSN28753084 510 COSMIC
COSN31480535 510 COSMIC
COSN31534974 676 COSMIC
COSN31577253 812 COSMIC
COSN31528700 892 COSMIC
COSN31596185 936 COSMIC
COSN31534125 968 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1369619860 5 dbSNP
rs377723904 6 dbSNP
rs1036990995 7 dbSNP
rs771595095 8 dbSNP
rs747674364 10 dbSNP
rs1250969370 13 dbSNP
rs778594412 14 dbSNP
rs1207305796 21 dbSNP
rs754632657 23 dbSNP
rs749620457 24 dbSNP
rs780595778 29 dbSNP
rs756622470 31 dbSNP
rs374029091 34 dbSNP
rs999041504 36 dbSNP
rs768198408 37 dbSNP
rs181580627 38 dbSNP
rs751632638 39 dbSNP
rs764356881 40 dbSNP
rs890803700 54 dbSNP
rs1043730992 57 dbSNP
rs1051172902 62 dbSNP
rs1169896730 63 dbSNP
rs1370605611 72 dbSNP
rs559374122 73 dbSNP
rs1473878259 74 dbSNP
rs932407929 79 dbSNP
rs1292280348 84 dbSNP
rs397822691 86 dbSNP
rs1295320171 87 dbSNP
rs3216837 87 dbSNP
rs397709399 87 dbSNP
rs889155604 88 dbSNP
rs1230925525 95 dbSNP
rs1050494014 106 dbSNP
rs1410250304 110 dbSNP
rs1220425939 118 dbSNP
rs1263606072 127 dbSNP
rs113394669 130 dbSNP
rs921036506 149 dbSNP
rs1489431574 150 dbSNP
rs1191505632 162 dbSNP
rs1260816469 165 dbSNP
rs376035474 169 dbSNP
rs933398264 171 dbSNP
rs1190089653 177 dbSNP
rs1390467069 179 dbSNP
rs922389297 183 dbSNP
rs541134865 185 dbSNP
rs867787921 187 dbSNP
rs1353684665 200 dbSNP
rs976599333 203 dbSNP
rs1458882070 205 dbSNP
rs989883792 212 dbSNP
rs936856503 215 dbSNP
rs766992980 220 dbSNP
rs978377750 225 dbSNP
rs939903770 233 dbSNP
rs967337411 234 dbSNP
rs1386866092 248 dbSNP
rs1407046910 248 dbSNP
rs1298588400 250 dbSNP
rs908439921 252 dbSNP
rs1243783135 253 dbSNP
rs1314969506 254 dbSNP
rs115998546 264 dbSNP
rs1222179788 270 dbSNP
rs1163600456 272 dbSNP
rs1463368553 273 dbSNP
rs1210434502 276 dbSNP
rs1248192572 277 dbSNP
rs1443649626 281 dbSNP
rs1024996090 289 dbSNP
rs1473932275 291 dbSNP
rs1423927052 292 dbSNP
rs1413810800 295 dbSNP
rs984465652 297 dbSNP
rs952408484 298 dbSNP
rs992144354 300 dbSNP
rs116622182 301 dbSNP
rs1304852849 303 dbSNP
rs1033761267 306 dbSNP
rs1223351074 310 dbSNP
rs1476692002 311 dbSNP
rs1231553565 314 dbSNP
rs991161921 317 dbSNP
rs1327007243 323 dbSNP
rs959802425 343 dbSNP
rs1229944955 356 dbSNP
rs1268547779 357 dbSNP
rs1460567574 359 dbSNP
rs1207544950 363 dbSNP
rs1238891456 367 dbSNP
rs995547757 371 dbSNP
rs1035794143 374 dbSNP
rs1201375419 379 dbSNP
rs1452704121 388 dbSNP
rs143510745 395 dbSNP
rs998966170 396 dbSNP
rs1428990400 400 dbSNP
rs898330412 405 dbSNP
rs774078109 416 dbSNP
rs1413169107 417 dbSNP
rs1289771817 420 dbSNP
rs1178492775 423 dbSNP
rs1211969331 431 dbSNP
rs967974865 434 dbSNP
rs1360036215 436 dbSNP
rs1441485819 443 dbSNP
rs188374952 455 dbSNP
rs891013396 458 dbSNP
rs555320473 459 dbSNP
rs1050982784 460 dbSNP
rs759209626 462 dbSNP
rs899490165 482 dbSNP
rs1012276793 492 dbSNP
rs541821302 494 dbSNP
rs114579443 510 dbSNP
rs1280288281 511 dbSNP
rs1312413448 512 dbSNP
rs1249011879 518 dbSNP
rs544927723 518 dbSNP
rs1483773821 523 dbSNP
rs1183507317 527 dbSNP
rs1268876477 532 dbSNP
rs553065114 535 dbSNP
rs762784366 540 dbSNP
rs1193293526 541 dbSNP
rs773176576 544 dbSNP
rs1409636880 561 dbSNP
rs1042928978 564 dbSNP
rs1166747539 565 dbSNP
rs1372447988 566 dbSNP
rs1430535599 574 dbSNP
rs1331666844 575 dbSNP
rs945548853 576 dbSNP
rs1433947550 587 dbSNP
rs1276409069 597 dbSNP
rs1459453390 601 dbSNP
rs186337368 602 dbSNP
rs1390179855 604 dbSNP
rs1272101113 612 dbSNP
rs1036474821 616 dbSNP
rs1159198054 625 dbSNP
rs11553705 629 dbSNP
rs918192861 636 dbSNP
rs1289712982 638 dbSNP
rs1450410521 660 dbSNP
rs1224180995 662 dbSNP
rs939849395 666 dbSNP
rs908408413 670 dbSNP
rs1475312779 676 dbSNP
rs992362543 677 dbSNP
rs1186881905 683 dbSNP
rs570479739 697 dbSNP
rs1048298244 706 dbSNP
rs558698474 713 dbSNP
rs1163011923 720 dbSNP
rs926588130 734 dbSNP
rs536865478 735 dbSNP
rs991129240 739 dbSNP
rs1350230290 740 dbSNP
rs1192283061 741 dbSNP
rs963088568 744 dbSNP
rs879741218 756 dbSNP
rs1248755173 758 dbSNP
rs928372691 763 dbSNP
rs1015444991 774 dbSNP
rs977616236 774 dbSNP
rs1228422723 780 dbSNP
rs1004476697 781 dbSNP
rs1283119824 784 dbSNP
rs1315367809 788 dbSNP
rs569904820 791 dbSNP
rs1464716046 803 dbSNP
rs1029617008 804 dbSNP
rs1465524453 809 dbSNP
rs1345419942 813 dbSNP
rs1302646650 825 dbSNP
rs1473845287 826 dbSNP
rs1164916495 827 dbSNP
rs1438654679 836 dbSNP
rs953775234 840 dbSNP
rs780107194 844 dbSNP
rs1456445563 845 dbSNP
rs996762789 846 dbSNP
rs1318308735 853 dbSNP
rs899500407 858 dbSNP
rs1028967225 860 dbSNP
rs1435398503 864 dbSNP
rs1054095449 868 dbSNP
rs999968297 875 dbSNP
rs1246426737 877 dbSNP
rs1320651595 878 dbSNP
rs1329083536 911 dbSNP
rs548081317 912 dbSNP
rs1270444445 915 dbSNP
rs1330042254 927 dbSNP
rs1200059333 937 dbSNP
rs901868204 944 dbSNP
rs1429393658 946 dbSNP
rs1444195336 954 dbSNP
rs529995753 957 dbSNP
rs1046607 958 dbSNP
rs1036445262 961 dbSNP
rs945569765 972 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545216. RNA binding protein: AGO2. Condition:miR-124 transfection PAR-CLIP data was present in GSM545217. RNA binding protein: AGO2. Condition:miR-7 transfection ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' cacacgagagaccagUUGGUAg 5'
                         |||||| 
Target 5' uacuuacuacacaugAACCAUa 3'
17 - 38
Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 51645.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714644. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
Experimental Support 3 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 51645.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM1065667. RNA binding protein: AGO1. Condition:4-thiouridine ...

- Memczak S; Jens M; Elefsinioti A; Torti F; et al., 2013, Nature.

Article - Memczak S; Jens M; Elefsinioti A; Torti F; et al.
- Nature, 2013
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.
LinkOut: [PMID: 23446348]
CLIP-seq Support 1 for dataset GSM545216
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / miR-124 transfection
Location of target site ENST00000373699.5 | 3UTR | UUUAUCAAUAGGUGACUACUUACUACACAUGAACCAUAAUGCUGCUUCUUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM545217
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / miR-7 transfection
Location of target site ENST00000373699.5 | 3UTR | UUUAUCAAUAGGUGACUACUUACUACACAUGAACCAUAAUGCUGCUUCUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM714644
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repA
Location of target site ENST00000373699.5 | 3UTR | UGUUUAUCAAUAGGUGACUACUUACUACACAUGAACCAUAAUGCUGCUUCUUGUGCAUGUCUGCUCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM1065667
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / 4-thiouridine, ML_MM_6
Location of target site ENST00000373699.5 | 3UTR | UUUAUCAAUAGGUGACUACUUACUACACAUGAACCAUAAUGCUGCUUCUUGUGCAUGUCUGCUCU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
62 hsa-miR-758-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT085323 MORC3 MORC family CW-type zinc finger 3 2 2
MIRT089441 STAMBP STAM binding protein 2 2
MIRT089456 TET3 tet methylcytosine dioxygenase 3 2 2
MIRT111856 CCND1 cyclin D1 2 2
MIRT184933 ZNF268 zinc finger protein 268 2 2
MIRT215288 CREBRF CREB3 regulatory factor 2 2
MIRT237300 LPP LIM domain containing preferred translocation partner in lipoma 2 2
MIRT238446 MYO10 myosin X 2 4
MIRT273827 RPL41 ribosomal protein L41 2 2
MIRT282703 HOOK1 hook microtubule tethering protein 1 2 2
MIRT347970 ZNF850 zinc finger protein 850 2 2
MIRT371076 KLF3 Kruppel like factor 3 2 2
MIRT464339 USP6NL USP6 N-terminal like 2 2
MIRT470034 PTP4A1 protein tyrosine phosphatase type IVA, member 1 2 2
MIRT477506 ELL2 elongation factor for RNA polymerase II 2 2 2
MIRT482886 CACNA2D3 calcium voltage-gated channel auxiliary subunit alpha2delta 3 2 2
MIRT492606 POLR3E RNA polymerase III subunit E 2 2
MIRT502294 GNG12 G protein subunit gamma 12 2 6
MIRT507600 DCTN4 dynactin subunit 4 2 4
MIRT510728 SON SON DNA binding protein 2 6
MIRT514065 KCNJ6 potassium voltage-gated channel subfamily J member 6 2 8
MIRT519718 ZNF512B zinc finger protein 512B 2 4
MIRT520890 STRN striatin 2 2
MIRT521760 PPIL1 peptidylprolyl isomerase like 1 2 6
MIRT526874 ERCC8 ERCC excision repair 8, CSA ubiquitin ligase complex subunit 2 2
MIRT530232 WSB2 WD repeat and SOCS box containing 2 2 2
MIRT532003 ACTR2 ARP2 actin related protein 2 homolog 2 2
MIRT533371 UBE2D4 ubiquitin conjugating enzyme E2 D4 (putative) 2 4
MIRT547106 PIGW phosphatidylinositol glycan anchor biosynthesis class W 2 2
MIRT548189 FOXA1 forkhead box A1 2 2
MIRT552935 VKORC1L1 vitamin K epoxide reductase complex subunit 1 like 1 2 2
MIRT560085 ZNF195 zinc finger protein 195 2 2
MIRT561726 PPP2CA protein phosphatase 2 catalytic subunit alpha 2 2
MIRT562713 ZNF415 zinc finger protein 415 2 2
MIRT562761 ZNF846 zinc finger protein 846 2 2
MIRT564159 ZNF117 zinc finger protein 117 2 2
MIRT565673 SETD5 SET domain containing 5 2 2
MIRT565718 SESN3 sestrin 3 2 2
MIRT566026 RFX1 regulatory factor X1 2 2
MIRT569048 ZNF655 zinc finger protein 655 2 2
MIRT570367 UBE2V1 ubiquitin conjugating enzyme E2 V1 2 2
MIRT570410 TMEM189-UBE2V1 TMEM189-UBE2V1 readthrough 2 2
MIRT570443 TMEM189 transmembrane protein 189 2 2
MIRT571738 RNF11 ring finger protein 11 2 2
MIRT575042 Tpgs2 tubulin polyglutamylase complex subunit 2 2 4
MIRT614330 ZDHHC22 zinc finger DHHC-type containing 22 2 2
MIRT617629 RAB3IP RAB3A interacting protein 2 2
MIRT621667 UBE4B ubiquitination factor E4B 2 2
MIRT639906 SRGAP2 SLIT-ROBO Rho GTPase activating protein 2 2 2
MIRT651436 XRCC5 X-ray repair cross complementing 5 2 2
MIRT683853 ZNF208 zinc finger protein 208 2 2
MIRT684841 TPGS2 tubulin polyglutamylase complex subunit 2 2 5
MIRT689347 ZNF83 zinc finger protein 83 2 2
MIRT692492 SPIN4 spindlin family member 4 2 2
MIRT695711 OLA1 Obg like ATPase 1 2 2
MIRT698219 TMEM248 transmembrane protein 248 2 2
MIRT711560 FAM20B FAM20B, glycosaminoglycan xylosylkinase 2 2
MIRT712867 TMEM67 transmembrane protein 67 2 2
MIRT722956 TSPAN1 tetraspanin 1 2 2
MIRT723622 SOBP sine oculis binding protein homolog 2 2
MIRT724176 ABCF2 ATP binding cassette subfamily F member 2 2 2
MIRT755363 LMBR1 limb development membrane protein 1 3 1
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-758 Hydroxycamptothecin (HCPT) NULL 97226 Microarray human Tenon's fibroblasts (HTFs) 24681041 2014 down-regulated
miR-758 Diethylstilbestrol approved 448537 Microarray mammosphere-derived epithelial cells (MDEC) 19549897 2009 up-regulated
miR-758 5-Fluorouracil approved 3385 Quantitative real-time PCR human squamous cell carcinoma cell line KYSE410 21743970 2011 up-regulated
miR-758 Reversine NULL 210332 Microarray C2C12 myoblast cells 24513286 2014 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-758 Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-758 Fluorouracil 3385 NSC19893 approved resistant cell line (KYSE)
hsa-mir-758 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-758-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-758-5p Osimertinib 71496458 NSC779217 approved sensitive cell line (HCC827)
hsa-miR-758-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-758-5p Paclitaxel 36314 NSC125973 approved sensitive cell line (BAS)
hsa-miR-758-5p Doxorubicin 31703 NSC123127 approved sensitive cell line (BAS)
hsa-miR-758-5p Osimertinib 71496458 NSC779217 approved resistant cell line (H1975)
hsa-miR-758-5p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)
hsa-miR-758-5p Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)

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