miRTarBase - #MIRT523836


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pre-miRNA Information
pre-miRNA hsa-mir-640   
Genomic Coordinates chr19: 19435063 - 19435158
Synonyms MIRN640, hsa-mir-640, MIR640
Description Homo sapiens miR-640 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-640
Sequence 61| AUGAUCCAGGAACCUGCCUCU |81
Evidence Experimental
Experiments RT-PCR
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN30153378 1 COSMIC
COSN23015356 12 COSMIC
COSN30513185 19 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs111726405 1 dbSNP
rs765622881 2 dbSNP
rs1249744889 6 dbSNP
rs752995186 12 dbSNP
rs758746736 13 dbSNP
rs918887970 19 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol F2RL1   
Synonyms GPR11, PAR2
Description F2R like trypsin receptor 1
Transcript NM_005242   
Expression
Putative miRNA Targets on F2RL1
3'UTR of F2RL1
(miRNA target sites are highlighted)		 
>F2RL1|NM_005242|3'UTR
   1 GTTTTCCAGGTCCTCAGATGGGAATTGCACAGTAGGATGTGGAACCTGTTTAATGTTATGAGGACGTGTCTGTTATTTCC
  81 TAATCAAAAAGGTCTCACCACATACCATGTGGATGCAGCACCTCTCAGGATTGCTAGGAGCTCCCCTGTTTGCATGAGAA
 161 AAGTAGTCCCCCAAATTAACATCAGTGTCTGTTTCAGAATCTCTCTACTCAGATGACCCCAGAAACTGAACCAACAGAAG
 241 CAGACTTTTCAGAAGATGGTGAAGACAGAAACCCAGTAACTTGCAAAAAGTAGACTTGGTGTGAAGACTCACTTCTCAGC
 321 TGAAATTATATATATACACATATATATATTTTACATCTGGGATCATGATAGACTTGTTAGGGCTTCAAGGCCCTCAGAGA
 401 TGATCAGTCCAACTGAACGACCTTACAAATGAGGAAACCAAGATAAATGAGCTGCCAGAATCAGGTTTCCAATCAACAGC
 481 AGTGAGTTGGGATTGGACAGTAGAATTTCAATGTCCAGTGAGTGAGGTTCTTGTACCACTTCATCAAAATCATGGATCTT
 561 GGCTGGGTGCGGTGCCTCATGCCTGTAATCCTAGCACTTTGGGAGGCTGAGGCAGGCAATCACTTGAGGTCAGGAGTTCG
 641 AGACCAGCCTGGCCATCATGGCGAAACCTCATCTCTACTAAAAATACAAAAGTTAACCAGGTGTGTGGTGCACGTTTGTA
 721 ATCCCAGTTACTCAGGAGGCTGAGGCACAAGAATTGAGTATCACTTTAACTCAGGAGGCAGAGGTTGCAGTGAGCCGAGA
 801 TTGCACCACTGCACTCCAGCTTGGGTGATAAAATAAAATAAAATAGTCGTGAATCTTGTTCAAAATGCAGATTCCTCAGA
 881 TTCAATAATGAGAGCTCAGACTGGGAACAGGGCCCAGGAATCTGTGTGGTACAAACCTGCATGGTGTTTATGCACACAGA
 961 GATTTGAGAACCATTGTTCTGAATGCTGCTTCCATTTGACAAAGTGCCGTGATAATTTTTGAAAAGAGAAGCAAACAATG
1041 GTGTCTCTTTTATGTTCAGCTTATAATGAAATCTGTTTGTTGACTTATTAGGACTTTGAATTATTTCTTTATTAACCCTC
1121 TGAGTTTTTGTATGTATTATTATTAAAGAAAAATGCAATCAGGATTTTAAACATGTAAATACAAATTTTGTATAACTTTT
1201 GATGACTTCAGTGAAATTTTCAGGTAGTCTGAGTAATAGATTGTTTTGCCACTTAGAATAGCATTTGCCACTTAGTATTT
1281 TAAAAAATAATTGTTGGAGTATTTATTGTCAGTTTTGTTCACTTGTTATCTAATACAAAATTATAAAGCCTTCAGAGGGT
1361 TTGGACCACATCTCTTTGGAAAATAGTTTGCAACATATTTAAGAGATACTTGATGCCAAAATGACTTTATACAACGATTG
1441 TATTTGTGACTTTTAAAAATAATTATTTTATTGTGTAATTGATTTATAAATAACAAAATTTTTTTTACAACTTAAAAAAA
1521 AAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' ucuccGUCCAAGGACCUAGua 5'
               ||   || ||||||  
Target 5' ttcatCAAAATCATGGATCtt 3'
 540 - 560 128.00 -7.40
2 
miRNA  3' ucucCGUCCAAGGACCUAGUa 5'
              | :||||  |||| || 
Target 5' ttcaGAGGGTT--TGGACCAc 3'
 1351 - 1369 121.00 -10.30
3 
miRNA  3' ucuccguccaaggaCCUAGUa 5'
                        |||||| 
Target 5' atattttacatctgGGATCAt 3'
 346 - 366 120.00 -10.70
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30187069 18 COSMIC
COSN30483813 22 COSMIC
COSN26975566 64 COSMIC
COSN31612334 67 COSMIC
COSN15661506 108 COSMIC
COSN30490014 112 COSMIC
COSN30447797 134 COSMIC
COSN30455894 146 COSMIC
COSN20101399 350 COSMIC
COSN4851948 571 COSMIC
COSN5865663 627 COSMIC
COSN21348450 1046 COSMIC
COSN26778711 1181 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs748792492 1 dbSNP
rs769180337 3 dbSNP
rs779342435 7 dbSNP
rs748538129 9 dbSNP
rs772427569 13 dbSNP
rs1467542489 17 dbSNP
rs1201401419 18 dbSNP
rs1163345760 19 dbSNP
rs2243084 22 dbSNP
rs187721390 23 dbSNP
rs1325689223 25 dbSNP
rs770958350 26 dbSNP
rs376212863 28 dbSNP
rs189860773 29 dbSNP
rs2243063 30 dbSNP
rs751458316 31 dbSNP
rs569299379 35 dbSNP
rs1356965647 40 dbSNP
rs1324114225 49 dbSNP
rs1025820977 50 dbSNP
rs529274010 56 dbSNP
rs888624547 66 dbSNP
rs146054906 67 dbSNP
rs2243064 79 dbSNP
rs1392765651 86 dbSNP
rs1403268887 87 dbSNP
rs1278650964 102 dbSNP
rs1335416870 104 dbSNP
rs535427440 109 dbSNP
rs143647822 113 dbSNP
rs1469761219 123 dbSNP
rs1407431458 130 dbSNP
rs565779111 137 dbSNP
rs534668337 146 dbSNP
rs930211294 149 dbSNP
rs557576114 154 dbSNP
rs1185286469 162 dbSNP
rs1048656653 168 dbSNP
rs1241375081 174 dbSNP
rs1242348885 177 dbSNP
rs2243065 181 dbSNP
rs1461800831 186 dbSNP
rs1280712472 191 dbSNP
rs1349766524 192 dbSNP
rs909859666 192 dbSNP
rs1279847589 200 dbSNP
rs942724956 219 dbSNP
rs1380055575 223 dbSNP
rs1313781570 224 dbSNP
rs1039726263 233 dbSNP
rs1382410546 235 dbSNP
rs976859023 236 dbSNP
rs1399462048 242 dbSNP
rs376383495 245 dbSNP
rs1202049453 249 dbSNP
rs1029702061 278 dbSNP
rs998312382 304 dbSNP
rs1159452397 329 dbSNP
rs1421780292 330 dbSNP
rs1158094601 333 dbSNP
rs1183201032 334 dbSNP
rs62365147 336 dbSNP
rs1445375959 338 dbSNP
rs35226539 340 dbSNP
rs62365148 340 dbSNP
rs70982645 340 dbSNP
rs1246246746 341 dbSNP
rs35323826 341 dbSNP
rs566827130 345 dbSNP
rs1267831781 346 dbSNP
rs1429256086 348 dbSNP
rs891648582 349 dbSNP
rs1299310083 354 dbSNP
rs1402296875 358 dbSNP
rs759769643 368 dbSNP
rs1163253974 392 dbSNP
rs1425460204 393 dbSNP
rs771309279 403 dbSNP
rs772459618 405 dbSNP
rs956657538 412 dbSNP
rs2243085 414 dbSNP
rs537268108 419 dbSNP
rs1398692453 429 dbSNP
rs3135469 434 dbSNP
rs979029135 440 dbSNP
rs1311843682 444 dbSNP
rs1222780977 445 dbSNP
rs1323092005 449 dbSNP
rs927128692 452 dbSNP
rs992616359 463 dbSNP
rs918738342 466 dbSNP
rs1339445956 473 dbSNP
rs1279447656 478 dbSNP
rs951563898 485 dbSNP
rs1237829366 486 dbSNP
rs2243066 488 dbSNP
rs542600555 489 dbSNP
rs895496150 496 dbSNP
rs1351792319 497 dbSNP
rs929607551 498 dbSNP
rs1047320673 499 dbSNP
rs559366027 504 dbSNP
rs775502372 512 dbSNP
rs942672585 537 dbSNP
rs1172815595 546 dbSNP
rs1201751986 549 dbSNP
rs1040100177 553 dbSNP
rs1199821375 567 dbSNP
rs2243067 571 dbSNP
rs1458109874 572 dbSNP
rs1040300970 576 dbSNP
rs764212952 577 dbSNP
rs934049431 580 dbSNP
rs571965986 585 dbSNP
rs1052557999 586 dbSNP
rs1221017626 598 dbSNP
rs1321970485 599 dbSNP
rs1200325767 601 dbSNP
rs2243068 601 dbSNP
rs1220214976 619 dbSNP
rs182575884 624 dbSNP
rs1278062597 625 dbSNP
rs891593517 630 dbSNP
rs1436325746 636 dbSNP
rs1010090920 638 dbSNP
rs1181324459 641 dbSNP
rs1378332347 653 dbSNP
rs565259436 659 dbSNP
rs899989792 660 dbSNP
rs1001491553 661 dbSNP
rs998278137 663 dbSNP
rs1429215197 668 dbSNP
rs1470275539 669 dbSNP
rs1034412228 675 dbSNP
rs764267533 678 dbSNP
rs1460458277 681 dbSNP
rs1263117814 688 dbSNP
rs1314378022 693 dbSNP
rs149930351 702 dbSNP
rs2243069 712 dbSNP
rs145017560 714 dbSNP
rs1377868883 715 dbSNP
rs371907637 716 dbSNP
rs1323790249 720 dbSNP
rs984263874 728 dbSNP
rs1467457829 730 dbSNP
rs910084839 730 dbSNP
rs1343225255 766 dbSNP
rs532226442 771 dbSNP
rs866320882 776 dbSNP
rs1221156469 781 dbSNP
rs1282028928 784 dbSNP
rs922579399 785 dbSNP
rs375089406 790 dbSNP
rs927155811 791 dbSNP
rs988606937 798 dbSNP
rs1249445928 803 dbSNP
rs368806393 805 dbSNP
rs1215474356 823 dbSNP
rs778005769 828 dbSNP
rs945828420 828 dbSNP
rs1268314066 836 dbSNP
rs1244048845 845 dbSNP
rs868602923 849 dbSNP
rs904381184 850 dbSNP
rs779766822 868 dbSNP
rs916973673 869 dbSNP
rs937243315 876 dbSNP
rs1055729608 877 dbSNP
rs895449892 880 dbSNP
rs1268221012 893 dbSNP
rs1400435829 894 dbSNP
rs1013926448 895 dbSNP
rs1161356728 897 dbSNP
rs1025784550 899 dbSNP
rs1478457185 902 dbSNP
rs36066481 913 dbSNP
rs201009228 916 dbSNP
rs369526981 916 dbSNP
rs757355827 923 dbSNP
rs1426111266 925 dbSNP
rs1260314708 928 dbSNP
rs35274750 940 dbSNP
rs1193550674 942 dbSNP
rs1005296192 952 dbSNP
rs753529875 958 dbSNP
rs929658241 1005 dbSNP
rs1220549215 1007 dbSNP
rs2243070 1009 dbSNP
rs909532964 1010 dbSNP
rs2243071 1013 dbSNP
rs537632941 1014 dbSNP
rs1305814576 1022 dbSNP
rs549342443 1022 dbSNP
rs1219166207 1027 dbSNP
rs753853855 1029 dbSNP
rs1342149701 1039 dbSNP
rs955516364 1042 dbSNP
rs760446634 1054 dbSNP
rs1390959666 1055 dbSNP
rs534549684 1074 dbSNP
rs900000981 1076 dbSNP
rs1460071379 1077 dbSNP
rs1401821395 1084 dbSNP
rs998330727 1094 dbSNP
rs1371988860 1098 dbSNP
rs1170595866 1108 dbSNP
rs1051191508 1117 dbSNP
rs1426256619 1118 dbSNP
rs1451361365 1121 dbSNP
rs892581528 1121 dbSNP
rs1009635373 1122 dbSNP
rs534930455 1125 dbSNP
rs1479738081 1129 dbSNP
rs979540907 1131 dbSNP
rs1199209431 1132 dbSNP
rs1281182170 1135 dbSNP
rs1319851292 1135 dbSNP
rs762023152 1141 dbSNP
rs766193566 1142 dbSNP
rs1245253398 1148 dbSNP
rs146194119 1156 dbSNP
rs376364152 1157 dbSNP
rs1034233222 1159 dbSNP
rs1395157914 1164 dbSNP
rs937209932 1165 dbSNP
rs1056079982 1174 dbSNP
rs1291193608 1182 dbSNP
rs1477937747 1185 dbSNP
rs1378569499 1196 dbSNP
rs754913009 1205 dbSNP
rs1046709569 1211 dbSNP
rs958553196 1214 dbSNP
rs886797068 1230 dbSNP
rs1188866271 1232 dbSNP
rs1199307352 1240 dbSNP
rs1459125085 1244 dbSNP
rs567614928 1248 dbSNP
rs1260264119 1250 dbSNP
rs1005244021 1251 dbSNP
rs1428377999 1264 dbSNP
rs147763831 1271 dbSNP
rs899974780 1289 dbSNP
rs997026403 1290 dbSNP
rs1448414484 1293 dbSNP
rs1422409585 1298 dbSNP
rs1335397815 1300 dbSNP
rs113368839 1318 dbSNP
rs1360673679 1323 dbSNP
rs1174627994 1326 dbSNP
rs1451937601 1327 dbSNP
rs1379965721 1334 dbSNP
rs955642682 1346 dbSNP
rs951158657 1349 dbSNP
rs1420984860 1350 dbSNP
rs988822660 1354 dbSNP
rs982550989 1375 dbSNP
rs968054502 1386 dbSNP
rs909545379 1393 dbSNP
rs1203201615 1402 dbSNP
rs940996240 1423 dbSNP
rs1361210120 1428 dbSNP
rs1396492373 1430 dbSNP
rs1040378343 1436 dbSNP
rs926698396 1437 dbSNP
rs573164812 1439 dbSNP
rs1244126563 1441 dbSNP
rs545102761 1443 dbSNP
rs1051287508 1446 dbSNP
rs1360279711 1447 dbSNP
rs1159551831 1451 dbSNP
rs1421685847 1457 dbSNP
rs892634309 1460 dbSNP
rs945478904 1473 dbSNP
rs558997126 1480 dbSNP
rs752294684 1483 dbSNP
rs1002188816 1487 dbSNP
rs1034693299 1495 dbSNP
rs1263548400 1495 dbSNP
rs941047990 1498 dbSNP
rs1288565313 1499 dbSNP
rs575690460 1499 dbSNP
rs1201501093 1503 dbSNP
rs143476361 1508 dbSNP
rs1357828261 1509 dbSNP
rs1286529323 1514 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 2150.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM1065667. RNA binding protein: AGO1. Condition:4-thiouridine ...

- Memczak S; Jens M; Elefsinioti A; Torti F; et al., 2013, Nature.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' ucuccguccaaggACCUAGUa 5'
                       ||||||| 
Target 5' ---------ugggUGGAUCAc 3'
 		1 - 12
Article - Memczak S; Jens M; Elefsinioti A; Torti F; et al.
- Nature, 2013
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.
LinkOut: [PMID: 23446348]
CLIP-seq Support 1 for dataset GSM1065667
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / 4-thiouridine, ML_MM_6
Location of target site ENST00000296677.4 | 3UTR | UGGGUGGAUCACCCG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28544 Breast cancer -0.665 2.0e-4 -0.693 8.7e-5 24 Click to see details
GSE17306 Multiple myeloma -0.316 1.3e-2 -0.130 1.9e-1 49 Click to see details
GSE28260 Renal cortex and medulla -0.577 1.9e-2 -0.589 1.7e-2 13 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.367 3.6e-2 -0.208 1.6e-1 25 Click to see details
GSE26953 Aortic valvular endothelial cells 0.329 5.8e-2 0.439 1.6e-2 24 Click to see details
GSE32688 Pancreatic cancer -0.223 1.1e-1 -0.258 7.7e-2 32 Click to see details
GSE19536 Breast cancer 0.113 1.3e-1 0.085 2.0e-1 100 Click to see details
GSE35602 Colorectal cancer stromal tissue -0.216 1.5e-1 -0.209 1.6e-1 25 Click to see details
GSE17498 Multiple myeloma 0.142 1.9e-1 0.181 1.3e-1 40 Click to see details
GSE14794 Lymphoblastoid cells 0.082 2.2e-1 0.103 1.7e-1 90 Click to see details
GSE27834 Pluripotent stem cells -0.197 2.3e-1 -0.191 2.4e-1 16 Click to see details
GSE42095 Differentiated embryonic stem cells 0.136 2.7e-1 0.000 5.0e-1 23 Click to see details
GSE19783 ER- ER- breast cancer 0.063 2.9e-1 0.007 4.8e-1 79 Click to see details
GSE19350 CNS germ cell tumors -0.087 3.9e-1 0.154 3.2e-1 12 Click to see details
GSE21687 Ependynoma primary tumors -0.034 3.9e-1 -0.027 4.2e-1 64 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.06 4.0e-1 -0.256 1.4e-1 20 Click to see details
GSE19783 ER+ ER+ breast cancer 0.051 4.2e-1 -0.071 3.8e-1 20 Click to see details
GSE38226 Liver fibrosis 0.011 4.8e-1 0.004 4.9e-1 21 Click to see details
GSE38226 Liver fibrosis 0.011 4.8e-1 0.004 4.9e-1 21 Click to see details
GSE38226 Liver fibrosis 0.011 4.8e-1 0.004 4.9e-1 21 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
194 hsa-miR-640 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT097121 TNPO1 transportin 1 2 2
MIRT115090 ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 2 4
MIRT204603 HSPE1-MOB4 HSPE1-MOB4 readthrough 2 8
MIRT204634 MOB4 MOB family member 4, phocein 2 8
MIRT344451 MTRNR2L1 MT-RNR2-like 1 2 2
MIRT405772 EIF5 eukaryotic translation initiation factor 5 2 2
MIRT445876 SENP6 SUMO1/sentrin specific peptidase 6 2 2
MIRT497418 FAM46A family with sequence similarity 46 member A 2 2
MIRT504394 HMX2 H6 family homeobox 2 2 4
MIRT504691 SLCO2B1 solute carrier organic anion transporter family member 2B1 2 8
MIRT512386 MTRNR2L3 MT-RNR2-like 3 2 6
MIRT513003 MAN1A2 mannosidase alpha class 1A member 2 2 2
MIRT513084 USP9X ubiquitin specific peptidase 9, X-linked 2 2
MIRT519122 ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) 2 2
MIRT523836 F2RL1 F2R like trypsin receptor 1 2 2
MIRT565356 TMCC1 transmembrane and coiled-coil domain family 1 2 2
MIRT575895 Dis3 DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease 2 3
MIRT576894 Poteg POTE ankyrin domain family, member G 2 2
MIRT613780 RPS6 ribosomal protein S6 2 2
MIRT613934 POLR3A RNA polymerase III subunit A 2 2
MIRT614348 LOH12CR1 BLOC-1 related complex subunit 5 2 2
MIRT614534 NOA1 nitric oxide associated 1 2 2
MIRT617019 ZBTB8B zinc finger and BTB domain containing 8B 2 2
MIRT618247 MANEAL mannosidase endo-alpha like 2 2
MIRT619051 TTC4 tetratricopeptide repeat domain 4 2 2
MIRT619442 ZNF517 zinc finger protein 517 2 2
MIRT619723 FPR2 formyl peptide receptor 2 2 2
MIRT620179 TRIM72 tripartite motif containing 72 2 2
MIRT620370 ANKRD62 ankyrin repeat domain 62 2 2
MIRT621263 RTN2 reticulon 2 2 2
MIRT621463 APOH apolipoprotein H 2 2
MIRT621571 ZBTB43 zinc finger and BTB domain containing 43 2 2
MIRT621683 TSPYL1 TSPY like 1 2 2
MIRT622866 PDE7A phosphodiesterase 7A 2 2
MIRT624669 ARHGEF39 Rho guanine nucleotide exchange factor 39 2 2
MIRT625607 ZNF84 zinc finger protein 84 2 2
MIRT626111 IL23R interleukin 23 receptor 2 2
MIRT628380 CACNB2 calcium voltage-gated channel auxiliary subunit beta 2 2 2
MIRT628553 MELK maternal embryonic leucine zipper kinase 2 2
MIRT628671 C2orf72 chromosome 2 open reading frame 72 2 2
MIRT628747 TRPV2 transient receptor potential cation channel subfamily V member 2 2 2
MIRT628776 TMEM154 transmembrane protein 154 2 2
MIRT628918 ZNF430 zinc finger protein 430 2 2
MIRT629174 ALDOA aldolase, fructose-bisphosphate A 2 2
MIRT629209 C12orf66 chromosome 12 open reading frame 66 2 2
MIRT629267 SLC5A8 solute carrier family 5 member 8 2 2
MIRT629498 AS3MT arsenite methyltransferase 2 2
MIRT629665 USP1 ubiquitin specific peptidase 1 2 2
MIRT629760 STK25 serine/threonine kinase 25 2 2
MIRT630899 GATAD1 GATA zinc finger domain containing 1 2 2
MIRT631105 SLC15A2 solute carrier family 15 member 2 2 2
MIRT631112 ATCAY ATCAY, caytaxin 2 2
MIRT631450 DLEU1 deleted in lymphocytic leukemia 1 (non-protein coding) 2 2
MIRT631505 FFAR4 free fatty acid receptor 4 2 2
MIRT631580 ITGAL integrin subunit alpha L 2 2
MIRT631836 CMBL carboxymethylenebutenolidase homolog 2 2
MIRT632342 SWSAP1 SWIM-type zinc finger 7 associated protein 1 2 2
MIRT633214 ZNF584 zinc finger protein 584 2 2
MIRT633223 ZNF43 zinc finger protein 43 2 2
MIRT633480 ARIH2OS ariadne RBR E3 ubiquitin protein ligase 2 opposite strand 2 2
MIRT633511 LRRC27 leucine rich repeat containing 27 2 2
MIRT633615 CWF19L1 CWF19 like 1, cell cycle control (S. pombe) 2 2
MIRT633652 SLC28A1 solute carrier family 28 member 1 2 2
MIRT633677 ZNF576 zinc finger protein 576 2 2
MIRT634196 TMOD2 tropomodulin 2 2 4
MIRT634388 PLSCR1 phospholipid scramblase 1 2 2
MIRT635817 OPA3 OPA3, outer mitochondrial membrane lipid metabolism regulator 2 2
MIRT635962 TTC31 tetratricopeptide repeat domain 31 2 2
MIRT636114 YPEL1 yippee like 1 2 2
MIRT636164 TIMM8A translocase of inner mitochondrial membrane 8A 2 2
MIRT636768 CLUAP1 clusterin associated protein 1 2 2
MIRT637092 CXorf23 BCLAF1 and THRAP3 family member 3 2 2
MIRT637316 FAM9B family with sequence similarity 9 member B 2 2
MIRT637540 CHST6 carbohydrate sulfotransferase 6 2 2
MIRT637628 ZNF431 zinc finger protein 431 2 2
MIRT637826 CACNG8 calcium voltage-gated channel auxiliary subunit gamma 8 2 2
MIRT637945 IVD isovaleryl-CoA dehydrogenase 2 2
MIRT637968 IRF1 interferon regulatory factor 1 2 2
MIRT638321 RNF11 ring finger protein 11 2 2
MIRT638386 RAB11FIP1 RAB11 family interacting protein 1 2 2
MIRT639244 CRK CRK proto-oncogene, adaptor protein 2 2
MIRT642608 APOPT1 apoptogenic 1, mitochondrial 2 2
MIRT642793 SLC1A5 solute carrier family 1 member 5 2 2
MIRT643847 LACTB lactamase beta 2 4
MIRT644705 ZNF321P zinc finger protein 321, pseudogene 2 2
MIRT645148 DIS3 DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease 2 3
MIRT646671 CCDC69 coiled-coil domain containing 69 2 2
MIRT647780 ASB8 ankyrin repeat and SOCS box containing 8 2 2
MIRT648554 WDR92 WD repeat domain 92 2 2
MIRT648990 MRPL49 mitochondrial ribosomal protein L49 2 2
MIRT649099 KCNMB1 potassium calcium-activated channel subfamily M regulatory beta subunit 1 2 2
MIRT650141 ZNF426 zinc finger protein 426 2 2
MIRT650791 GSR glutathione-disulfide reductase 2 2
MIRT654967 PLEKHA2 pleckstrin homology domain containing A2 2 2
MIRT655099 PHLDA3 pleckstrin homology like domain family A member 3 2 2
MIRT655516 PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 2 2
MIRT656289 METTL14 methyltransferase like 14 2 2
MIRT656497 MAP3K9 mitogen-activated protein kinase kinase kinase 9 2 2
MIRT657074 JPH2 junctophilin 2 2 2
MIRT657314 HOOK3 hook microtubule tethering protein 3 2 2
MIRT657419 HIF1AN hypoxia inducible factor 1 alpha subunit inhibitor 2 4
MIRT659032 DHTKD1 dehydrogenase E1 and transketolase domain containing 1 2 2
MIRT659535 CHCHD5 coiled-coil-helix-coiled-coil-helix domain containing 5 2 2
MIRT661532 NWD1 NACHT and WD repeat domain containing 1 2 2
MIRT662029 FUT2 fucosyltransferase 2 2 2
MIRT663206 DARS2 aspartyl-tRNA synthetase 2, mitochondrial 2 2
MIRT663357 ORAI2 ORAI calcium release-activated calcium modulator 2 2 2
MIRT663557 CCR6 C-C motif chemokine receptor 6 2 2
MIRT663650 POLM DNA polymerase mu 2 2
MIRT663694 ABHD17B abhydrolase domain containing 17B 2 2
MIRT664370 CYB5A cytochrome b5 type A 2 2
MIRT664783 LIAS lipoic acid synthetase 2 4
MIRT665561 TXNL1 thioredoxin like 1 2 2
MIRT665950 TAOK1 TAO kinase 1 2 2
MIRT667338 MSANTD3 Myb/SANT DNA binding domain containing 3 2 2
MIRT667804 ITIH5 inter-alpha-trypsin inhibitor heavy chain family member 5 2 2
MIRT668804 CYP20A1 cytochrome P450 family 20 subfamily A member 1 2 2
MIRT669470 ARPC2 actin related protein 2/3 complex subunit 2 2 2
MIRT669599 AGO3 argonaute 3, RISC catalytic component 2 2
MIRT669806 STOML1 stomatin like 1 2 2
MIRT669944 FBXL2 F-box and leucine rich repeat protein 2 2 2
MIRT670292 RBBP4 RB binding protein 4, chromatin remodeling factor 2 2
MIRT670381 EMP2 epithelial membrane protein 2 2 2
MIRT670481 DCUN1D2 defective in cullin neddylation 1 domain containing 2 2 2
MIRT670531 KIF1C kinesin family member 1C 2 4
MIRT670565 GLTP glycolipid transfer protein 2 2
MIRT670603 NPHP1 nephrocystin 1 2 2
MIRT670880 CYTIP cytohesin 1 interacting protein 2 2
MIRT670931 LIPG lipase G, endothelial type 2 2
MIRT671261 MTRNR2L5 MT-RNR2-like 5 2 2
MIRT671794 FLVCR1 feline leukemia virus subgroup C cellular receptor 1 2 2
MIRT671897 GBP4 guanylate binding protein 4 2 2
MIRT672000 SLC35F6 solute carrier family 35 member F6 2 4
MIRT672074 KIR3DX1 killer cell immunoglobulin like receptor, three Ig domains X1 2 2
MIRT672319 C9orf3 chromosome 9 open reading frame 3 2 2
MIRT672853 C22orf29 retrotransposon Gag like 10 2 2
MIRT673395 WNT7B Wnt family member 7B 2 2
MIRT673537 DEGS1 delta 4-desaturase, sphingolipid 1 2 2
MIRT674285 ZNF724P zinc finger protein 724 2 2
MIRT674494 TIRAP TIR domain containing adaptor protein 2 2
MIRT675460 NUBPL nucleotide binding protein like 2 2
MIRT675569 TRIP11 thyroid hormone receptor interactor 11 2 2
MIRT676068 TIMM50 translocase of inner mitochondrial membrane 50 2 2
MIRT676254 PBOV1 prostate and breast cancer overexpressed 1 2 2
MIRT676377 SEC24D SEC24 homolog D, COPII coat complex component 2 2
MIRT676758 SNX2 sorting nexin 2 2 2
MIRT676773 NPHS1 NPHS1, nephrin 2 2
MIRT676874 ENSA endosulfine alpha 2 2
MIRT676918 KLHDC8A kelch domain containing 8A 2 2
MIRT676944 S1PR3 sphingosine-1-phosphate receptor 3 2 2
MIRT676957 HFE hemochromatosis 2 2
MIRT676967 RNF19B ring finger protein 19B 2 2
MIRT676972 ZNF708 zinc finger protein 708 2 2
MIRT677042 ZNF34 zinc finger protein 34 2 2
MIRT677070 VMAC vimentin type intermediate filament associated coiled-coil protein 2 2
MIRT677093 MFSD11 major facilitator superfamily domain containing 11 2 4
MIRT677134 P2RX7 purinergic receptor P2X 7 2 2
MIRT677179 ZNF786 zinc finger protein 786 2 2
MIRT677228 C15orf40 chromosome 15 open reading frame 40 2 2
MIRT677320 PIGO phosphatidylinositol glycan anchor biosynthesis class O 2 2
MIRT677455 PDLIM3 PDZ and LIM domain 3 2 2
MIRT677809 MRPS10 mitochondrial ribosomal protein S10 2 2
MIRT677937 ZNF519 zinc finger protein 519 2 2
MIRT678063 UBN2 ubinuclein 2 2 4
MIRT678072 EIF2A eukaryotic translation initiation factor 2A 2 2
MIRT678252 FXN frataxin 2 2
MIRT678315 FBLIM1 filamin binding LIM protein 1 2 2
MIRT678367 XIAP X-linked inhibitor of apoptosis 2 4
MIRT678372 RNF115 ring finger protein 115 2 2
MIRT678410 ANKRD36 ankyrin repeat domain 36 2 2
MIRT678518 ZNF347 zinc finger protein 347 2 2
MIRT678566 CDK4 cyclin dependent kinase 4 2 2
MIRT678580 PPP1R3B protein phosphatase 1 regulatory subunit 3B 2 2
MIRT678820 PDE6A phosphodiesterase 6A 2 2
MIRT678917 XPOT exportin for tRNA 2 2
MIRT679217 MAN2A2 mannosidase alpha class 2A member 2 2 2
MIRT679437 C19orf52 translocase of inner mitochondrial membrane 29 2 2
MIRT679595 HILPDA hypoxia inducible lipid droplet associated 2 2
MIRT679755 TLR6 toll like receptor 6 2 2
MIRT679800 APOBEC3A apolipoprotein B mRNA editing enzyme catalytic subunit 3A 2 2
MIRT680057 CD96 CD96 molecule 2 2
MIRT680116 CCDC30 coiled-coil domain containing 30 2 4
MIRT680181 ZNF554 zinc finger protein 554 2 2
MIRT680439 WDR12 WD repeat domain 12 2 2
MIRT680789 ZNF578 zinc finger protein 578 2 2
MIRT692464 APEX2 apurinic/apyrimidinic endodeoxyribonuclease 2 2 2
MIRT702952 HIP1 huntingtin interacting protein 1 2 2
MIRT706016 ZSCAN2 zinc finger and SCAN domain containing 2 2 2
MIRT706032 F2R coagulation factor II thrombin receptor 2 2
MIRT706135 MTRNR2L10 MT-RNR2-like 10 2 2
MIRT706394 HAS2 hyaluronan synthase 2 2 2
MIRT713293 DCP2 decapping mRNA 2 2 2
MIRT716583 BRAP BRCA1 associated protein 2 2
MIRT720433 C19orf47 chromosome 19 open reading frame 47 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-640 Paclitaxel 36314 NSC125973 approved resistant High Ovarian Cancer tissue and cell line (SKOV3)
hsa-miR-640 Cetuximab resistant High Colon Cancer cell line
hsa-miR-640 Trametinib 11707110 NSC758246 approved resistant High Melanoma cell line (WM266) (1uM)
hsa-miR-640 Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (WM266) (1uM)
hsa-miR-640 Mitoxantrone 4212 NSC279836 approved resistant High Breast Cancer cell line (BT-20, BT-474, BT-549, CAMA-1, HCC1143, HCC1395, HCC1569, HCC1806, HCC-1937, HCC1954, HCC202, HCC38, HCC70, Hs578T, MCF-7, MDA-MB-175VII, MDA-MB-231, MDA-MB-361, MDA-MB-415, MDA-MB-436, MDA-MB-468, SKBR3, T47D, UACC812, EVSA-T, MPE-600 , SK-BR-
hsa-miR-640 Sorafenib 216239 NSC747971 approved sensitive Low Clear Cell Renal Cell Carcinoma cell line (786-O)
hsa-mir-640 Paclitaxel 36314 NSC125973 approved sensitive cell line (A2780)
hsa-mir-640 Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-mir-640 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-miR-640 Sunitinib 5329102 NSC750690 approved resistant tissue (CardB)
hsa-miR-640 Paclitaxel 36314 NSC125973 approved sensitive cell line (SKOV3)
hsa-miR-640 Tamoxifen 2733525 NSC180973 approved sensitive cell line (TamR8)
hsa-miR-640 Oxaliplatin 6857599 NSC266046 approved sensitive cell line (IGROV-1)
hsa-miR-640 Cisplatin 5460033 NSC119875 approved sensitive cell line (IGROV-1)
hsa-miR-640 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

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