miRTarBase - #MIRT523891


—
pre-miRNA Information
pre-miRNA hsa-mir-4666a   
Genomic Coordinates chr1: 228462074 - 228462152
Description Homo sapiens miR-4666a stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4666a-5p
Sequence 10| AUACAUGUCAGAUUGUAUGCC |30
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1288210208 3 dbSNP
rs1333314792 5 dbSNP
rs562096649 7 dbSNP
rs1324809033 10 dbSNP
rs1027635037 13 dbSNP
rs1351630778 15 dbSNP
rs1034879562 18 dbSNP
rs1383267208 21 dbSNP
Putative Targets

Gene Information
Gene Symbol ENPP6   
Synonyms NPP6
Description ectonucleotide pyrophosphatase/phosphodiesterase 6
Transcript NM_153343   
Expression
Putative miRNA Targets on ENPP6
3'UTR of ENPP6
(miRNA target sites are highlighted)		 
>ENPP6|NM_153343|3'UTR
   1 CTGATCATATTGCTTGTCTCAGAAAAAAACACCATCAGCAAAGTGGGCCTCCAAAGCCAGATGATTTTCATTTTATGTGT
  81 GAATAATAGCTTCATTAACACAATCAAGACCATGCACATTGTAAATACATTATTCTTGGATAATTCTATACATAAAAGTT
 161 CCTACTTGTTAAAAAAGATACAAACCTTGTTTTTCCAGAAGGTAGGAAAATCCTAGCTTTCCATTTGTGCAGTTATATGT
 241 CATTTTCTCCTTTCTTTTCACGTTACTCAGGATGAACTCTCTGAGCAGGGACCTGCTCCTGCAGCAACCAAACTTGGAGT
 321 GGTTATTGCAGACAGACGTGGCTCTGGGCCCCTCTCTGTCCCACCTTGCACAAAGGACCCCCTCAGACCAGGCCCTTGTC
 401 TGTGCCCTGTCCACACCCAGGAGCCATCCTCAGTGTCTGTGGCCACAATCCTGTACTGTTCCTTCCATCCCTGATAAAAG
 481 GAGGTCTACATGAAAGCAAAAGCTACTGTCTATTTCTGACCCAGCTCATGGAATTTTTTCATCTTATACTGAGCTCCAGA
 561 AAGGACGTAACTTAGCATGGATCACCAATCAATCAAAAAATAAATAAATCACTAAGGATTGGAGAACTCATAGAACAAGG
 641 TGAAAGACATGAGTGCCCTCCCAAAGTCTGAGTGCACGAAAATTTCTCTCTTGCCTTGAGGAGCAGAAAAGCTTCTGATG
 721 GACATGGGCTTCTGTGAGACTTATCACACATAGTGTATCGTGGCATGAAGCCCGGCACATAGCAGGCCCTGCATATTGAT
 801 GGACAAATGGATGGCCTGCCTGCCTTCCCTGTCCGTTCACCTGTGCAAAGGCTTCCTCAGACATGCCACTCTGTGGCTCC
 881 CAATATAGGGTGCAGACAAGAGCAATCCCTGACATGACATTATAGCCTGGGAAAGGGCTGGCTCACTGATGAGAATGTGG
 961 AGGCATCAGCAAGGATCTCGGTGGGTTGCTCAGAGAGGTGATGCACTAAGCCTTAATCCTGGACACCAGTACCCCTGCAG
1041 CATGGCTTGCTCAACAACAGTCTTTGAGTGGCATAGAATTCCAAAGAAAATGGTGCTGGGTGGAGAATGGAGAGAGCATG
1121 ATGGAGCAGAGTCCCAGTCACTGACCAACTAACTGGTCGTTTGATTAGGAAACAGTTTGGCCAAAGTACCACCTTTGAGA
1201 CCTAAGTTCTTTTGATACCTTTGAGAAGAGCCACTGAGCCTGAGTTGAAATATTTTTAGCTTAGTCATCTGTGTTTGCTA
1281 TAGGAGAAATTGTAACACAAGAAATAACTCCTTTTTACATGATCATTTATATCTATATACATATATATACTTGCATACAC
1361 TATCACTGCATTAAAAAATGAGTTTGGGCTGGGCATGGTGGCTCACACCTATAATCCCAACACTTTCGGAGGCCAAGGAG
1441 GGACAAACGAACCCTTGAGGCCAGGAGTTCCAGACTAACTTGGGCAACACAGGGCGACCCCCATCTCTACAAAACATAAA
1521 AGATTTTTAAAAAATTAGCCAGGCATGGTGGCACATGCCTGTGGTCTCAGCTACTTGGGAGGCTGAGGCAGGAGAATCAT
1601 TTGAGCCCAGGAGGTCAAGGCTGCAGTGAGCTTTGATCACACCACTGCACTCCAGCCTGGGCAACAGAGCAAGACCCCAT
1681 CCTCCACCCCCCCCAAAAAATAGAAAGAAAAAAAAAGTTTGCACTAATTGAGGTACATCTGCAAGTGAGACTTTTTGTCA
1761 GGAAAAGGCAATATATCAGGTCTCCTCAGGACGATGGAGGCCTTATATGGTGTGTTACCTTGAAAACTGAATATCAACGT
1841 TCACCTTGATTCAGGAAAGCTGGGTGCTGTCTCCATGCCATGAATCATGAGAGCAAAGGATCACTGCTTAAAAATACTGA
1921 ATTTACCTTCACAAAAGATTTCTAAAGATTTATGTAATGTGTTTTAAAAGCGCCAGTAAACCATCGGATCAATTGGAAAG
2001 AAGGCAACTCTTCAGCCTTTGTTATCTAGCTGAAAACAAATGACAACTTTCAAAACATTGGCAGTAGTTGTTGAAAAAGA
2081 CGTCTATTGTTCAAAGTTTCTTTCTCCTTAAAGGACGGTGTTCCAATGAATTCAGTAGAGCCCACTTTCCTCCACTGTGG
2161 AGGAAGAATCCCTAAGAGATACTCAAATGATTAAATTAAAATTGGATCATCAAACTCAAGAGAGGCATAAACTTAGACAC
2241 AGTCTTGCATTTTTGTCTTTCCTGAACTCTTCTGCCATTTTCCTCCTTCACTCGTCCTGAAAATCTGCAAGTTACATAAT
2321 AAAACTTTAGATATTTGTCTGACAAAGTGTAATTACTCAACTGAATAAATGACTGAGAACAAGTTACAAAAGGAATCATG
2401 AATCCTGGTAAACAATAAAGAAGATTCAGACACTGAGGGAAAAAAATAAAGCTTTTTACTTAAATAATGCA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' ccguaUGUUA--GACUGUACaua 5'
               :||||  ||||||||   
Target 5' caagaGCAATCCCTGACATGaca 3'
 897 - 919 126.00 -12.32
2 
miRNA  3' ccgUAUGUUAG-------AC-UGU-ACAUa 5'
             | ||||||       || ||| |||| 
Target 5' ttaACACAATCAAGACCATGCACATTGTAa 3'
 95 - 124 122.00 -6.85
3 
miRNA  3' ccgUAUGUU-----AGACUGUACAUa 5'
             ||| ||     ||| ||||| | 
Target 5' ctgATAAAAGGAGGTCT-ACATGAAa 3'
 471 - 495 121.00 -7.72
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31574811 3 COSMIC
COSN30479200 6 COSMIC
COSN31510651 16 COSMIC
COSN30108344 22 COSMIC
COSN31614220 64 COSMIC
COSN30154273 105 COSMIC
COSN30465311 128 COSMIC
COSN31539599 158 COSMIC
COSN31537468 177 COSMIC
COSN19444228 181 COSMIC
COSN31516176 208 COSMIC
COSN21119517 212 COSMIC
COSN31488616 241 COSMIC
COSN5057477 599 COSMIC
COSN25493094 773 COSMIC
COSN20091140 810 COSMIC
COSN26604740 823 COSMIC
COSN6819425 1051 COSMIC
COSN24888087 1311 COSMIC
COSN6819424 1415 COSMIC
COSN20100846 1687 COSMIC
COSN20409731 1694 COSMIC
COSN1293106 1707 COSMIC
COSN1293105 1708 COSMIC
COSN20100843 1708 COSMIC
COSN20994126 2057 COSMIC
COSN20091139 2060 COSMIC
COSN9893145 2082 COSMIC
COSN16577420 2178 COSMIC
COSN14864421 2365 COSMIC
COSN26460235 2393 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs767381240 3 dbSNP
rs141778895 8 dbSNP
rs1053627163 12 dbSNP
rs369220973 13 dbSNP
rs551669738 18 dbSNP
rs1003030643 30 dbSNP
rs759615464 30 dbSNP
rs936465824 30 dbSNP
rs762483821 31 dbSNP
rs1288687062 32 dbSNP
rs532936709 35 dbSNP
rs1327400774 43 dbSNP
rs756931616 51 dbSNP
rs376053175 54 dbSNP
rs1344770749 70 dbSNP
rs1435769230 72 dbSNP
rs970907383 77 dbSNP
rs1020721264 79 dbSNP
rs1188107412 80 dbSNP
rs1250456185 83 dbSNP
rs1009291911 86 dbSNP
rs1471383859 87 dbSNP
rs922626974 102 dbSNP
rs893484703 104 dbSNP
rs1364100517 105 dbSNP
rs976746563 108 dbSNP
rs1470108598 115 dbSNP
rs1271592927 119 dbSNP
rs17075294 121 dbSNP
rs1007522229 129 dbSNP
rs148041498 132 dbSNP
rs1307443481 137 dbSNP
rs1348739904 138 dbSNP
rs1411839322 147 dbSNP
rs1018741398 149 dbSNP
rs889031975 150 dbSNP
rs1330880930 163 dbSNP
rs984320143 165 dbSNP
rs1231589138 168 dbSNP
rs1349173780 176 dbSNP
rs952969329 178 dbSNP
rs528944321 179 dbSNP
rs1330380142 181 dbSNP
rs1025750969 197 dbSNP
rs994409260 201 dbSNP
rs1178560218 202 dbSNP
rs970948176 203 dbSNP
rs933152121 211 dbSNP
rs1196539228 212 dbSNP
rs563087248 213 dbSNP
rs1281392502 220 dbSNP
rs114117043 223 dbSNP
rs1167900147 226 dbSNP
rs10024098 229 dbSNP
rs894901389 232 dbSNP
rs1431780071 235 dbSNP
rs1298929551 236 dbSNP
rs541789495 241 dbSNP
rs1303814493 251 dbSNP
rs778583856 257 dbSNP
rs937617950 259 dbSNP
rs928884582 261 dbSNP
rs982077490 262 dbSNP
rs1206053876 265 dbSNP
rs761232703 267 dbSNP
rs1251505091 269 dbSNP
rs1487926058 277 dbSNP
rs1207732233 284 dbSNP
rs1254573422 289 dbSNP
rs1396430331 293 dbSNP
rs1454594846 308 dbSNP
rs1187849249 320 dbSNP
rs143548128 322 dbSNP
rs1430364694 325 dbSNP
rs1171172551 328 dbSNP
rs1042231436 331 dbSNP
rs1460891620 332 dbSNP
rs116504613 337 dbSNP
rs923144288 338 dbSNP
rs560703016 340 dbSNP
rs1395652123 341 dbSNP
rs1434910181 348 dbSNP
rs536493380 349 dbSNP
rs1215690382 351 dbSNP
rs1295626522 353 dbSNP
rs1320593795 362 dbSNP
rs754699719 372 dbSNP
rs574160495 378 dbSNP
rs114488141 397 dbSNP
rs1468726230 398 dbSNP
rs1207932837 408 dbSNP
rs1455265443 412 dbSNP
rs1486786227 413 dbSNP
rs537406938 414 dbSNP
rs1187046352 417 dbSNP
rs889058305 419 dbSNP
rs1251559193 425 dbSNP
rs17075291 432 dbSNP
rs1418896758 439 dbSNP
rs768846503 443 dbSNP
rs1286943826 447 dbSNP
rs918791879 456 dbSNP
rs1347347823 458 dbSNP
rs897658184 467 dbSNP
rs972875882 468 dbSNP
rs1377804799 470 dbSNP
rs1412429887 472 dbSNP
rs1294721241 475 dbSNP
rs1335027729 497 dbSNP
rs749413568 503 dbSNP
rs1227438131 513 dbSNP
rs78747890 514 dbSNP
rs1025146482 517 dbSNP
rs1011925899 518 dbSNP
rs1216390885 522 dbSNP
rs1236898475 526 dbSNP
rs1275453977 541 dbSNP
rs1482297842 550 dbSNP
rs1190207859 553 dbSNP
rs769702505 554 dbSNP
rs1472363674 560 dbSNP
rs887849028 566 dbSNP
rs556338007 567 dbSNP
rs1001051213 571 dbSNP
rs1301040831 573 dbSNP
rs745819130 578 dbSNP
rs36094133 587 dbSNP
rs1357978555 594 dbSNP
rs1437148855 610 dbSNP
rs1314141809 619 dbSNP
rs1439874279 621 dbSNP
rs542075226 631 dbSNP
rs1355550739 632 dbSNP
rs937376877 650 dbSNP
rs534924664 655 dbSNP
rs1345782294 669 dbSNP
rs928598178 675 dbSNP
rs185386307 677 dbSNP
rs1277798511 678 dbSNP
rs946253001 685 dbSNP
rs913443044 692 dbSNP
rs1281045111 694 dbSNP
rs990310537 699 dbSNP
rs780948074 719 dbSNP
rs1234855489 724 dbSNP
rs1470705449 728 dbSNP
rs997317056 730 dbSNP
rs1436247038 734 dbSNP
rs757096746 739 dbSNP
rs1392858738 748 dbSNP
rs1193468165 754 dbSNP
rs1375511717 759 dbSNP
rs549155703 760 dbSNP
rs901775106 762 dbSNP
rs1326406490 771 dbSNP
rs1355962931 772 dbSNP
rs1038946873 773 dbSNP
rs943283047 774 dbSNP
rs911244200 783 dbSNP
rs1048384210 796 dbSNP
rs1236327218 804 dbSNP
rs1304144100 807 dbSNP
rs1341510380 808 dbSNP
rs77782933 809 dbSNP
rs751377125 810 dbSNP
rs1438571019 817 dbSNP
rs200296603 822 dbSNP
rs1245292095 832 dbSNP
rs370170951 834 dbSNP
rs146361390 835 dbSNP
rs1390142338 841 dbSNP
rs918186452 843 dbSNP
rs758118105 845 dbSNP
rs1279873921 851 dbSNP
rs1005991460 860 dbSNP
rs1322490242 866 dbSNP
rs991501453 868 dbSNP
rs549489685 872 dbSNP
rs532722418 887 dbSNP
rs564120019 890 dbSNP
rs959635929 891 dbSNP
rs1032458208 892 dbSNP
rs1271936859 902 dbSNP
rs1325756831 903 dbSNP
rs1227949094 906 dbSNP
rs1271580581 909 dbSNP
rs540712028 912 dbSNP
rs1001991544 913 dbSNP
rs142325674 914 dbSNP
rs1313011755 915 dbSNP
rs573480708 916 dbSNP
rs1195959309 917 dbSNP
rs1243286094 919 dbSNP
rs1475487740 924 dbSNP
rs1162277731 950 dbSNP
rs979117904 958 dbSNP
rs1046145019 962 dbSNP
rs1462713122 964 dbSNP
rs946354538 966 dbSNP
rs1373315376 971 dbSNP
rs966457020 976 dbSNP
rs376711266 980 dbSNP
rs769489953 983 dbSNP
rs1327100282 985 dbSNP
rs1422122523 992 dbSNP
rs557298663 1002 dbSNP
rs1234161733 1020 dbSNP
rs1267821532 1023 dbSNP
rs1348999309 1032 dbSNP
rs1020687604 1054 dbSNP
rs1475401692 1055 dbSNP
rs1447045334 1062 dbSNP
rs1186544158 1073 dbSNP
rs112102971 1090 dbSNP
rs1475945775 1091 dbSNP
rs1188236363 1097 dbSNP
rs1410940725 1098 dbSNP
rs936175241 1099 dbSNP
rs911356498 1100 dbSNP
rs901699723 1108 dbSNP
rs1017423068 1114 dbSNP
rs1385639416 1114 dbSNP
rs764819326 1116 dbSNP
rs1007921889 1119 dbSNP
rs1288025302 1120 dbSNP
rs1334344578 1121 dbSNP
rs1241674353 1127 dbSNP
rs887696444 1129 dbSNP
rs1261702708 1132 dbSNP
rs193038452 1155 dbSNP
rs147664047 1158 dbSNP
rs557463042 1159 dbSNP
rs1211158713 1175 dbSNP
rs961958214 1178 dbSNP
rs1417062639 1182 dbSNP
rs1183654518 1184 dbSNP
rs931299017 1190 dbSNP
rs1364192959 1192 dbSNP
rs530390386 1193 dbSNP
rs114285165 1201 dbSNP
rs578040410 1209 dbSNP
rs951889176 1213 dbSNP
rs1307618733 1217 dbSNP
rs189155055 1218 dbSNP
rs1308070323 1219 dbSNP
rs918114819 1231 dbSNP
rs1232727443 1243 dbSNP
rs990995793 1244 dbSNP
rs1045760887 1251 dbSNP
rs534754226 1260 dbSNP
rs758904470 1266 dbSNP
rs1479428779 1273 dbSNP
rs938302978 1279 dbSNP
rs1250896847 1280 dbSNP
rs755742310 1284 dbSNP
rs891780382 1291 dbSNP
rs1293829283 1298 dbSNP
rs1191662808 1304 dbSNP
rs1416470531 1305 dbSNP
rs182366819 1308 dbSNP
rs1454746572 1321 dbSNP
rs1169779153 1322 dbSNP
rs189893262 1323 dbSNP
rs1390465005 1328 dbSNP
rs1439217001 1334 dbSNP
rs150069681 1336 dbSNP
rs1050339902 1339 dbSNP
rs1020613981 1340 dbSNP
rs1228348308 1350 dbSNP
rs1294149408 1378 dbSNP
rs1305270483 1387 dbSNP
rs774669933 1388 dbSNP
rs965776920 1391 dbSNP
rs1355898502 1395 dbSNP
rs371658456 1396 dbSNP
rs186951943 1398 dbSNP
rs1468808426 1400 dbSNP
rs369186695 1406 dbSNP
rs1185872425 1408 dbSNP
rs1409745480 1409 dbSNP
rs1259729028 1413 dbSNP
rs1017892891 1416 dbSNP
rs1430448101 1426 dbSNP
rs549426277 1427 dbSNP
rs922994927 1428 dbSNP
rs887701161 1434 dbSNP
rs975832728 1439 dbSNP
rs1027546006 1443 dbSNP
rs763172555 1448 dbSNP
rs995487181 1449 dbSNP
rs1167749284 1454 dbSNP
rs140603788 1456 dbSNP
rs564074805 1468 dbSNP
rs1383453760 1475 dbSNP
rs547349412 1483 dbSNP
rs1231080937 1485 dbSNP
rs1417283061 1495 dbSNP
rs775503558 1496 dbSNP
rs1214979759 1497 dbSNP
rs1258937678 1500 dbSNP
rs1486878307 1501 dbSNP
rs1187137649 1503 dbSNP
rs1256943676 1516 dbSNP
rs1474308649 1521 dbSNP
rs1190342854 1526 dbSNP
rs1419010054 1528 dbSNP
rs1481771759 1529 dbSNP
rs949506195 1534 dbSNP
rs951962275 1539 dbSNP
rs527323269 1542 dbSNP
rs151310894 1549 dbSNP
rs1454783968 1552 dbSNP
rs938164210 1554 dbSNP
rs971531249 1555 dbSNP
rs1412525929 1557 dbSNP
rs543363340 1558 dbSNP
rs1457161023 1559 dbSNP
rs979730912 1563 dbSNP
rs945596265 1564 dbSNP
rs913603195 1571 dbSNP
rs1318615614 1573 dbSNP
rs1216421270 1589 dbSNP
rs1279620958 1591 dbSNP
rs1235085361 1603 dbSNP
rs1213283480 1607 dbSNP
rs1258535257 1611 dbSNP
rs1469924844 1613 dbSNP
rs1175797987 1620 dbSNP
rs1410658633 1621 dbSNP
rs891811954 1625 dbSNP
rs1173623942 1632 dbSNP
rs1374317348 1635 dbSNP
rs1033006366 1637 dbSNP
rs1311449732 1648 dbSNP
rs1000491257 1649 dbSNP
rs975741869 1654 dbSNP
rs1441072856 1661 dbSNP
rs758856264 1670 dbSNP
rs934167090 1671 dbSNP
rs1302661301 1685 dbSNP
rs1277414650 1686 dbSNP
rs910265627 1687 dbSNP
rs1281154872 1688 dbSNP
rs986385169 1689 dbSNP
rs1437419886 1690 dbSNP
rs1440942854 1690 dbSNP
rs1234948866 1691 dbSNP
rs1481203145 1692 dbSNP
rs951891946 1693 dbSNP
rs28402798 1694 dbSNP
rs1027884283 1695 dbSNP
rs1356056019 1695 dbSNP
rs1491085976 1695 dbSNP
rs397996526 1695 dbSNP
rs536503950 1695 dbSNP
rs57589024 1695 dbSNP
rs1460372736 1696 dbSNP
rs57909391 1700 dbSNP
rs1394365907 1701 dbSNP
rs1160001424 1703 dbSNP
rs1368633385 1708 dbSNP
rs1420956507 1710 dbSNP
rs993406504 1715 dbSNP
rs1040102286 1717 dbSNP
rs1338888531 1717 dbSNP
rs143573880 1717 dbSNP
rs1176852837 1721 dbSNP
rs940410202 1730 dbSNP
rs961929233 1738 dbSNP
rs1015588360 1739 dbSNP
rs1213408114 1745 dbSNP
rs1454837633 1747 dbSNP
rs907579838 1751 dbSNP
rs984417663 1757 dbSNP
rs1013500995 1759 dbSNP
rs34809528 1762 dbSNP
rs1246765961 1767 dbSNP
rs1055192032 1769 dbSNP
rs1264788136 1772 dbSNP
rs927187284 1773 dbSNP
rs1216326530 1778 dbSNP
rs980012448 1782 dbSNP
rs971652937 1784 dbSNP
rs1239010914 1792 dbSNP
rs1002680301 1793 dbSNP
rs904049006 1797 dbSNP
rs142382368 1806 dbSNP
rs1325900501 1807 dbSNP
rs956108223 1809 dbSNP
rs945648492 1810 dbSNP
rs914115310 1811 dbSNP
rs1341321413 1819 dbSNP
rs1033036243 1824 dbSNP
rs1271600158 1832 dbSNP
rs1337484639 1837 dbSNP
rs796705919 1838 dbSNP
rs944328230 1839 dbSNP
rs910313827 1842 dbSNP
rs879389891 1845 dbSNP
rs1445894280 1864 dbSNP
rs889765757 1872 dbSNP
rs781237400 1873 dbSNP
rs985923340 1874 dbSNP
rs770960252 1882 dbSNP
rs746867281 1884 dbSNP
rs1415388267 1891 dbSNP
rs901345645 1893 dbSNP
rs1163750540 1895 dbSNP
rs777698626 1904 dbSNP
rs1037153929 1905 dbSNP
rs758210145 1916 dbSNP
rs1320298005 1919 dbSNP
rs578045909 1924 dbSNP
rs886170441 1933 dbSNP
rs971869618 1942 dbSNP
rs1291733069 1945 dbSNP
rs190357072 1948 dbSNP
rs1246044897 1954 dbSNP
rs1048742094 1958 dbSNP
rs961939010 1968 dbSNP
rs752400253 1971 dbSNP
rs1207412012 1972 dbSNP
rs1287467244 1974 dbSNP
rs1488365051 1976 dbSNP
rs1452345016 1983 dbSNP
rs1024143229 1985 dbSNP
rs926953865 1986 dbSNP
rs541398633 1991 dbSNP
rs980427274 1992 dbSNP
rs186035041 1993 dbSNP
rs1258473895 1999 dbSNP
rs1468488409 2000 dbSNP
rs917111495 2001 dbSNP
rs960761674 2004 dbSNP
rs988626392 2008 dbSNP
rs956139275 2013 dbSNP
rs1034083328 2016 dbSNP
rs926040804 2019 dbSNP
rs1002326083 2021 dbSNP
rs978818664 2028 dbSNP
rs954188745 2040 dbSNP
rs1231544050 2041 dbSNP
rs1310680202 2047 dbSNP
rs903932492 2048 dbSNP
rs563042638 2060 dbSNP
rs1296676793 2061 dbSNP
rs998877460 2068 dbSNP
rs1277615365 2075 dbSNP
rs1384452869 2076 dbSNP
rs1200693237 2079 dbSNP
rs1483992181 2079 dbSNP
rs1009701778 2080 dbSNP
rs535372663 2081 dbSNP
rs1040628463 2082 dbSNP
rs1004323722 2086 dbSNP
rs866385892 2087 dbSNP
rs1396974992 2093 dbSNP
rs888585086 2116 dbSNP
rs182040164 2117 dbSNP
rs1393549852 2119 dbSNP
rs1332489119 2120 dbSNP
rs1376883999 2121 dbSNP
rs569658439 2126 dbSNP
rs139203438 2134 dbSNP
rs1313497235 2138 dbSNP
rs544554087 2145 dbSNP
rs1044067198 2151 dbSNP
rs1250448615 2155 dbSNP
rs535440202 2156 dbSNP
rs950034364 2157 dbSNP
rs1200255027 2166 dbSNP
rs1238598170 2171 dbSNP
rs930450777 2172 dbSNP
rs1259555988 2179 dbSNP
rs539277351 2190 dbSNP
rs1269544041 2194 dbSNP
rs1192389477 2196 dbSNP
rs753268205 2198 dbSNP
rs920307111 2201 dbSNP
rs1433912160 2207 dbSNP
rs971880828 2212 dbSNP
rs1485717541 2214 dbSNP
rs1258938284 2218 dbSNP
rs1371502212 2223 dbSNP
rs1467408862 2225 dbSNP
rs1171750939 2229 dbSNP
rs1394219838 2237 dbSNP
rs1460323846 2240 dbSNP
rs1328594229 2252 dbSNP
rs1208314262 2256 dbSNP
rs1482701769 2258 dbSNP
rs940504880 2263 dbSNP
rs1369055635 2265 dbSNP
rs917061831 2270 dbSNP
rs1229853328 2277 dbSNP
rs191869059 2282 dbSNP
rs547192313 2293 dbSNP
rs566386741 2294 dbSNP
rs979263035 2296 dbSNP
rs1333968900 2304 dbSNP
rs954147119 2312 dbSNP
rs981140142 2316 dbSNP
rs968165675 2317 dbSNP
rs1185962723 2324 dbSNP
rs1259748337 2337 dbSNP
rs1440388023 2342 dbSNP
rs77835619 2345 dbSNP
rs567965930 2351 dbSNP
rs1009759031 2362 dbSNP
rs1395707333 2365 dbSNP
rs1167495647 2371 dbSNP
rs1397450984 2383 dbSNP
rs1453720028 2386 dbSNP
rs1287715043 2388 dbSNP
rs1298591474 2407 dbSNP
rs1015810722 2408 dbSNP
rs1278519878 2409 dbSNP
rs555416639 2413 dbSNP
rs1004395768 2429 dbSNP
rs1354550647 2437 dbSNP
rs1463331283 2440 dbSNP
rs549656111 2440 dbSNP
rs1421126244 2444 dbSNP
rs1169894574 2445 dbSNP
rs1314647798 2447 dbSNP
rs952883147 2451 dbSNP
rs1027073555 2452 dbSNP
rs1259024198 2457 dbSNP
rs866552470 2459 dbSNP
rs1217578891 2461 dbSNP
rs35381955 2465 dbSNP
rs892663981 2468 dbSNP
rs1185120625 2470 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545214. RNA binding protein: AGO3. Condition:Control PAR-CLIP data was present in GSM545216. RNA binding protein: AGO2. Condition:miR-124 transfection ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' ccguaUGUUAGAC-UGUACaua 5'
               ||: |||| |||||   
Target 5' ccugcACGUUCUGCACAUG--- 3'
 		8 - 26
Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 133121.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714644. RNA binding protein: AGO2. Condition:completeT1 "PAR-CLIP data was present in GSM714645. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
Experimental Support 3 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 133121.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM1065667. RNA binding protein: AGO1. Condition:4-thiouridine ...

- Memczak S; Jens M; Elefsinioti A; Torti F; et al., 2013, Nature.

Article - Memczak S; Jens M; Elefsinioti A; Torti F; et al.
- Nature, 2013
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.
LinkOut: [PMID: 23446348]
CLIP-seq Support 1 for dataset GSM545214
Method / RBP PAR-CLIP / AGO3
Cell line / Condition HEK293 / Control
Location of target site ENST00000296741.2 | 3UTR | UAACAAACCUGCACGUUCUGCACAUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM545216
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / miR-124 transfection
Location of target site ENST00000296741.2 | 3UTR | UAACAAACCUGCACGUUCUGCACAUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM714644
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repA
Location of target site ENST00000296741.2 | 3UTR | UAACAAACCUGCACGUUCUGCACAUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM714645
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repB
Location of target site ENST00000296741.2 | 3UTR | UAACAAACCUGCACGUUCUGCACAUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM1065667
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / 4-thiouridine, ML_MM_6
Location of target site ENST00000296741.2 | 3UTR | UAACAAACCUGCACGUUCUGCACAUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
83 hsa-miR-4666a-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT057266 FAM35A family with sequence similarity 35 member A 2 2
MIRT059969 PATL1 PAT1 homolog 1, processing body mRNA decay factor 2 6
MIRT079031 TNRC6C trinucleotide repeat containing 6C 2 2
MIRT079631 DNAJB4 DnaJ heat shock protein family (Hsp40) member B4 2 2
MIRT086974 LANCL1 LanC like 1 2 2
MIRT091804 GOLGA4 golgin A4 2 2
MIRT229501 EIF1AX eukaryotic translation initiation factor 1A, X-linked 2 4
MIRT255972 WDR17 WD repeat domain 17 2 2
MIRT262975 ADO 2-aminoethanethiol dioxygenase 2 2
MIRT264774 PAFAH1B2 platelet activating factor acetylhydrolase 1b catalytic subunit 2 2 2
MIRT334169 CCND1 cyclin D1 2 6
MIRT345868 SRSF2 serine and arginine rich splicing factor 2 2 2
MIRT452477 DDX4 DEAD-box helicase 4 2 2
MIRT455764 TSPAN6 tetraspanin 6 2 4
MIRT461627 DCAF15 DDB1 and CUL4 associated factor 15 2 4
MIRT465169 TRPV2 transient receptor potential cation channel subfamily V member 2 2 4
MIRT468950 RPS14 ribosomal protein S14 2 6
MIRT483236 C2orf72 chromosome 2 open reading frame 72 2 8
MIRT498544 TMEM30B transmembrane protein 30B 2 2
MIRT500633 TXNIP thioredoxin interacting protein 2 4
MIRT504113 GPR158 G protein-coupled receptor 158 2 2
MIRT504428 ZNF85 zinc finger protein 85 2 6
MIRT505036 ZNF451 zinc finger protein 451 2 2
MIRT506526 MRPL17 mitochondrial ribosomal protein L17 2 6
MIRT508773 GSG1 germ cell associated 1 2 2
MIRT517297 ELF4 E74 like ETS transcription factor 4 2 6
MIRT519353 OBFC1 STN1, CST complex subunit 2 4
MIRT523891 ENPP6 ectonucleotide pyrophosphatase/phosphodiesterase 6 2 6
MIRT527509 ZNF134 zinc finger protein 134 2 2
MIRT531218 IFNGR2 interferon gamma receptor 2 2 2
MIRT535957 MOGAT1 monoacylglycerol O-acyltransferase 1 2 2
MIRT537229 GALNT7 polypeptide N-acetylgalactosaminyltransferase 7 2 4
MIRT537337 FKBP5 FK506 binding protein 5 2 2
MIRT539125 ARHGEF17 Rho guanine nucleotide exchange factor 17 2 2
MIRT539910 ISPD isoprenoid synthase domain containing 2 2
MIRT541527 MGAT4C MGAT4 family member C 2 2
MIRT546119 USP25 ubiquitin specific peptidase 25 2 2
MIRT548846 CERCAM cerebral endothelial cell adhesion molecule 2 2
MIRT549892 LINC00955 long intergenic non-protein coding RNA 955 2 2
MIRT549898 ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide 2 2
MIRT550763 ENOX2 ecto-NOX disulfide-thiol exchanger 2 2 4
MIRT553200 UBE2A ubiquitin conjugating enzyme E2 A 2 2
MIRT553970 SRSF10 serine and arginine rich splicing factor 10 2 2
MIRT554092 SMU1 DNA replication regulator and spliceosomal factor 2 2
MIRT555208 PROX1 prospero homeobox 1 2 4
MIRT555834 PAX5 paired box 5 2 4
MIRT556865 JAZF1 JAZF zinc finger 1 2 2
MIRT558594 CREBL2 cAMP responsive element binding protein like 2 2 2
MIRT559690 AGO2 argonaute 2, RISC catalytic component 2 4
MIRT563312 ORC4 origin recognition complex subunit 4 2 2
MIRT563585 FAM229B family with sequence similarity 229 member B 2 2
MIRT563853 ALYREF Aly/REF export factor 2 4
MIRT565146 TUBB2A tubulin beta 2A class IIa 2 2
MIRT565769 SEPHS1 selenophosphate synthetase 1 2 2
MIRT568317 BACH1 BTB domain and CNC homolog 1 2 2
MIRT575387 Unc5b unc-5 netrin receptor B 2 4
MIRT607728 BDH1 3-hydroxybutyrate dehydrogenase 1 2 8
MIRT612691 PLXNA4 plexin A4 2 4
MIRT615916 GDPD1 glycerophosphodiester phosphodiesterase domain containing 1 2 2
MIRT629792 P2RY1 purinergic receptor P2Y1 2 2
MIRT632119 FKBP9 FK506 binding protein 9 2 2
MIRT645554 ZDHHC15 zinc finger DHHC-type containing 15 2 4
MIRT651479 WWC3 WWC family member 3 2 2
MIRT654138 RPH3A rabphilin 3A 2 6
MIRT655191 PHAX phosphorylated adaptor for RNA export 2 2
MIRT665543 UNC5B unc-5 netrin receptor B 2 5
MIRT668057 GRIK3 glutamate ionotropic receptor kainate type subunit 3 2 2
MIRT678978 CERS4 ceramide synthase 4 2 4
MIRT679124 RBM3 RNA binding motif (RNP1, RRM) protein 3 2 2
MIRT686776 AZF1 azoospermia factor 1 2 2
MIRT687144 PTPN12 protein tyrosine phosphatase, non-receptor type 12 2 2
MIRT691453 C21orf58 chromosome 21 open reading frame 58 2 2
MIRT691469 FAM98B family with sequence similarity 98 member B 2 2
MIRT697031 UHRF1BP1 UHRF1 binding protein 1 2 2
MIRT698401 TM9SF3 transmembrane 9 superfamily member 3 2 2
MIRT702056 RNMT RNA guanine-7 methyltransferase 2 2
MIRT705903 ADAM9 ADAM metallopeptidase domain 9 2 2
MIRT707491 MMADHC methylmalonic aciduria and homocystinuria, cblD type 2 2
MIRT708080 KLHL23 kelch like family member 23 2 2
MIRT709738 TRIM27 tripartite motif containing 27 2 2
MIRT710056 RWDD2A RWD domain containing 2A 2 2
MIRT710226 KCNK1 potassium two pore domain channel subfamily K member 1 2 2
MIRT712043 STYK1 serine/threonine/tyrosine kinase 1 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4666a Doxorubicin 31703 NSC123127 approved sensitive High Triple-Negative Breast Cancer cell line (MDA-MB-231, MDA-MB-468)

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