pre-miRNA Information
pre-miRNA hsa-mir-6871   
Genomic Coordinates chr20: 41169023 - 41169078
Description Homo sapiens miR-6871 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6871-3p
Sequence 35| CAGCACCCUGUGGCUCCCACAG |56
Evidence Experimental
Experiments Meta-analysis
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN16670239 4 COSMIC
COSN1872096 9 COSMIC
COSM1741616 16 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs545076040 1 dbSNP
rs1273348199 2 dbSNP
rs1202373059 5 dbSNP
rs1340707970 7 dbSNP
rs372994756 8 dbSNP
rs869070782 15 dbSNP
rs931272568 16 dbSNP
rs1333765165 18 dbSNP
Putative Targets

Gene Information
Gene Symbol DYNLT1   
Synonyms CW-1, TCTEL1, tctex-1
Description dynein light chain Tctex-type 1
Transcript NM_006519   
Expression
Putative miRNA Targets on DYNLT1
3'UTR of DYNLT1
(miRNA target sites are highlighted)
>DYNLT1|NM_006519|3'UTR
   1 CCTGCAGTCCAGCCTATGGCCTTTCTCCTTTTGTCTCTAGTTCATCCTCTAACCACCAGCCATGAATTCAGTGAACTCTT
  81 TTCTCATTCTCTTTGTTTTGTGGCACTTTCACAATGTAGAGGAAAAAACCAAATGACCGCACTGTGATGTGAATGGCACC
 161 GAAGTCAGATGAGTATCCCTGTAGGTCACCTGCAGCCTGCGTTGCCACTTGTCTTAACTCTGAATATTTCATTTCAAAGG
 241 TGCTAAAATCTGAAATCTGCTAGTGTGAAACTTGCTCTACTCTCTGAAATGATTCAAATACACTAATTTTCCATACTTTA
 321 TACTTTTGTTAGAATAAATTATTCAAATCTAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' gacacccucggugucCCACGAc 5'
                         |||||| 
Target 5' atatttcatttcaaaGGTGCTa 3'
224 - 245 120.00 -13.70
2
miRNA  3' gacACCCUCGGUG-UCCCACgac 5'
             ||  | |::| || |||   
Target 5' atcTGAAATCTGCTAGTGTGaaa 3'
248 - 270 83.00 -8.90
3
miRNA  3' gaCACCC--UCGGUGUCCCACGac 5'
            || ||  | |::|||  |||  
Target 5' ctGTAGGTCACCTGCAGCCTGCgt 3'
179 - 202 82.00 -15.90
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31570207 8 COSMIC
COSN31572076 63 COSMIC
COSN30100285 86 COSMIC
COSN30140159 103 COSMIC
COSN30167470 129 COSMIC
COSN2150523 138 COSMIC
COSN31603454 200 COSMIC
COSN31488465 295 COSMIC
COSN32063087 306 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs773624019 2 dbSNP
rs1387183042 5 dbSNP
rs369110116 8 dbSNP
rs762287311 12 dbSNP
rs1480478293 13 dbSNP
rs774456032 15 dbSNP
rs377082285 16 dbSNP
rs1382424537 18 dbSNP
rs1160074790 19 dbSNP
rs1457635369 24 dbSNP
rs1343646804 28 dbSNP
rs1009608336 29 dbSNP
rs775419589 33 dbSNP
rs1185418140 35 dbSNP
rs372218711 37 dbSNP
rs770399418 44 dbSNP
rs775515782 44 dbSNP
rs1475874606 46 dbSNP
rs953352136 48 dbSNP
rs1237582486 49 dbSNP
rs373781147 50 dbSNP
rs548180101 53 dbSNP
rs1381688316 54 dbSNP
rs1243724401 55 dbSNP
rs185645544 56 dbSNP
rs778058027 59 dbSNP
rs1317016695 64 dbSNP
rs1003036491 72 dbSNP
rs1238756575 72 dbSNP
rs1266760055 86 dbSNP
rs1198595955 87 dbSNP
rs193220458 90 dbSNP
rs576274744 93 dbSNP
rs756804471 93 dbSNP
rs898552785 95 dbSNP
rs931430073 95 dbSNP
rs1037041447 99 dbSNP
rs568998445 104 dbSNP
rs1202721357 106 dbSNP
rs77988642 113 dbSNP
rs776688153 115 dbSNP
rs1003604626 116 dbSNP
rs1405807053 119 dbSNP
rs1050982861 120 dbSNP
rs1804639 122 dbSNP
rs576726927 129 dbSNP
rs906592986 134 dbSNP
rs1405111734 136 dbSNP
rs768677608 138 dbSNP
rs140838911 139 dbSNP
rs948040788 154 dbSNP
rs1277283905 155 dbSNP
rs565369998 160 dbSNP
rs796343671 161 dbSNP
rs967826334 164 dbSNP
rs1323323419 166 dbSNP
rs1265602654 168 dbSNP
rs73583683 179 dbSNP
rs1181634885 181 dbSNP
rs1376018025 182 dbSNP
rs1471172829 184 dbSNP
rs1178048118 193 dbSNP
rs1296773245 193 dbSNP
rs528806948 200 dbSNP
rs935494803 201 dbSNP
rs41267051 209 dbSNP
rs960650977 211 dbSNP
rs987860218 211 dbSNP
rs1176694313 216 dbSNP
rs1337064059 219 dbSNP
rs1442257418 220 dbSNP
rs1470708511 220 dbSNP
rs1035928051 222 dbSNP
rs560145374 224 dbSNP
rs924078240 226 dbSNP
rs1195755802 230 dbSNP
rs1804638 239 dbSNP
rs1271477086 240 dbSNP
rs879002051 249 dbSNP
rs1175677933 254 dbSNP
rs977593419 259 dbSNP
rs1003067723 262 dbSNP
rs1268524408 276 dbSNP
rs1479588614 286 dbSNP
rs541858193 286 dbSNP
rs115317069 288 dbSNP
rs1474945204 291 dbSNP
rs1175196350 299 dbSNP
rs1166125572 303 dbSNP
rs147180354 305 dbSNP
rs1302001504 311 dbSNP
rs544003862 311 dbSNP
rs749442500 313 dbSNP
rs1406424347 314 dbSNP
rs898611790 315 dbSNP
rs1027535063 316 dbSNP
rs1227114212 316 dbSNP
rs1244033950 321 dbSNP
rs1342073071 322 dbSNP
rs1229720875 323 dbSNP
rs1205797511 325 dbSNP
rs1004239321 326 dbSNP
rs778004286 327 dbSNP
rs756425668 331 dbSNP
rs1268273275 332 dbSNP
rs1262537872 333 dbSNP
rs1051063488 338 dbSNP
rs1190736876 340 dbSNP
rs1319186337 345 dbSNP
rs932574670 345 dbSNP
rs1305329771 346 dbSNP
rs1491193912 348 dbSNP
rs1491441525 349 dbSNP
rs921142821 349 dbSNP
rs372045234 352 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 6993.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714644. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' gacacccucggugucCCACGAc 5'
                         |||||| 
Target 5' auauuucauuucaaaGGUGCUa 3'
2 - 23
Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 6993.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM1065667. RNA binding protein: AGO1. Condition:4-thiouridine ...

- Memczak S; Jens M; Elefsinioti A; Torti F; et al., 2013, Nature.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' gacacccucggugucCCACGAc 5'
                         |||||| 
Target 5' auauuucauuucaaaGGUGCUa 3'
2 - 23
Article - Memczak S; Jens M; Elefsinioti A; Torti F; et al.
- Nature, 2013
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.
LinkOut: [PMID: 23446348]
CLIP-seq Support 1 for dataset GSM714644
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repA
Location of target site ENST00000367088.1 | 3UTR | AAUAUUUCAUUUCAAAGGUGCUAAAAUCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1065667
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / 4-thiouridine, ML_MM_6
Location of target site ENST00000367088.1 | 3UTR | AAUAUUUCAUUUCAAAGGUGCUAAAAUCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
88 hsa-miR-6871-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT061678 BTG2 BTG anti-proliferation factor 2 2 4
MIRT116181 NUFIP2 NUFIP2, FMR1 interacting protein 2 2 2
MIRT150139 MIDN midnolin 2 2
MIRT197058 NKIRAS2 NFKB inhibitor interacting Ras like 2 2 2
MIRT225108 GOLGA7 golgin A7 2 2
MIRT376288 CALM3 calmodulin 3 2 2
MIRT454810 NEDD9 neural precursor cell expressed, developmentally down-regulated 9 2 2
MIRT464228 VEGFA vascular endothelial growth factor A 2 6
MIRT466961 STAT3 signal transducer and activator of transcription 3 2 2
MIRT468219 SGK1 serum/glucocorticoid regulated kinase 1 2 2
MIRT472460 NASP nuclear autoantigenic sperm protein 2 2
MIRT474203 LEPRE1 prolyl 3-hydroxylase 1 1 1
MIRT475836 HDGF heparin binding growth factor 2 4
MIRT478667 CTC1 CST telomere replication complex component 1 2 14
MIRT478707 CSRNP2 cysteine and serine rich nuclear protein 2 2 2
MIRT478982 COMMD2 COMM domain containing 2 2 2
MIRT479693 CCNT2 cyclin T2 2 6
MIRT488440 ULBP2 UL16 binding protein 2 2 2
MIRT492511 RAET1L retinoic acid early transcript 1L 2 2
MIRT492975 NCS1 neuronal calcium sensor 1 2 2
MIRT494158 COL4A1 collagen type IV alpha 1 chain 2 6
MIRT495934 SLC7A5P2 solute carrier family 7 member 5 pseudogene 2 2 2
MIRT496210 PLEKHG2 pleckstrin homology and RhoGEF domain containing G2 2 2
MIRT496356 PPY pancreatic polypeptide 2 2
MIRT496385 ZC3H6 zinc finger CCCH-type containing 6 2 2
MIRT496463 DCTN5 dynactin subunit 5 2 2
MIRT497642 GLDN gliomedin 2 2
MIRT498496 FRK fyn related Src family tyrosine kinase 2 2
MIRT501928 MCL1 MCL1, BCL2 family apoptosis regulator 2 8
MIRT513286 PDPK1 3-phosphoinositide dependent protein kinase 1 2 2
MIRT514767 RBM4B RNA binding motif protein 4B 2 2
MIRT514916 MDM2 MDM2 proto-oncogene 2 6
MIRT515669 LRRC27 leucine rich repeat containing 27 2 2
MIRT520367 UBE2G2 ubiquitin conjugating enzyme E2 G2 2 2
MIRT523960 DYNLT1 dynein light chain Tctex-type 1 2 4
MIRT526859 KIFC1 kinesin family member C1 2 2
MIRT527673 CASP8 caspase 8 2 2
MIRT527828 TMEM74B transmembrane protein 74B 2 2
MIRT529553 EI24 EI24, autophagy associated transmembrane protein 2 2
MIRT530547 SYNPO synaptopodin 2 2
MIRT531725 TARS threonyl-tRNA synthetase 2 2
MIRT533340 UNC119B unc-119 lipid binding chaperone B 2 2
MIRT533620 TNFRSF13C TNF receptor superfamily member 13C 2 2
MIRT537226 GAN gigaxonin 2 2
MIRT544430 ZNF460 zinc finger protein 460 2 4
MIRT546905 PTP4A1 protein tyrosine phosphatase type IVA, member 1 2 2
MIRT547102 PLAG1 PLAG1 zinc finger 2 2
MIRT547820 ISG20L2 interferon stimulated exonuclease gene 20 like 2 2 2
MIRT548236 FEM1B fem-1 homolog B 2 2
MIRT550034 WWTR1 WW domain containing transcription regulator 1 2 2
MIRT554337 SH3GLB1 SH3 domain containing GRB2 like, endophilin B1 2 4
MIRT565483 SPRTN SprT-like N-terminal domain 2 2
MIRT568200 CBX6 chromobox 6 2 2
MIRT569754 C2orf71 chromosome 2 open reading frame 71 2 2
MIRT571369 ZNF45 zinc finger protein 45 2 2
MIRT609886 CLASP1 cytoplasmic linker associated protein 1 2 4
MIRT640543 C3orf36 chromosome 3 open reading frame 36 2 2
MIRT640885 ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1 2 2
MIRT643494 LRCH3 leucine rich repeats and calponin homology domain containing 3 2 2
MIRT643627 YY2 YY2 transcription factor 2 2
MIRT644384 ZNF286A zinc finger protein 286A 2 2
MIRT646126 SLC26A9 solute carrier family 26 member 9 2 2
MIRT655939 NDUFA4P1 NDUFA4, mitochondrial complex associated pseudogene 1 2 2
MIRT656057 MYLK4 myosin light chain kinase family member 4 2 2
MIRT658767 EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2 2 2
MIRT661583 EPHX2 epoxide hydrolase 2 2 2
MIRT664285 RNMTL1 mitochondrial rRNA methyltransferase 3 2 2
MIRT689391 ZNF850 zinc finger protein 850 2 2
MIRT694530 TRIM72 tripartite motif containing 72 2 2
MIRT694626 ZFPM1 zinc finger protein, FOG family member 1 2 2
MIRT695133 PRY2 PTPN13-like, Y-linked 2 2 2
MIRT695150 PRY PTPN13-like, Y-linked 2 2
MIRT697468 ZC3H4 zinc finger CCCH-type containing 4 2 2
MIRT701919 MLXIP MLX interacting protein 2 2
MIRT704548 CNBP CCHC-type zinc finger nucleic acid binding protein 2 2
MIRT704791 CDK6 cyclin dependent kinase 6 2 2
MIRT705696 ANKRD13A ankyrin repeat domain 13A 2 2
MIRT707992 OTUD4 OTU deubiquitinase 4 2 2
MIRT708739 FAM71F2 family with sequence similarity 71 member F2 2 2
MIRT713401 FAM179A TOG array regulator of axonemal microtubules 2 2 2
MIRT713846 FAM3D family with sequence similarity 3 member D 2 2
MIRT716998 ARL6IP4 ADP ribosylation factor like GTPase 6 interacting protein 4 2 2
MIRT718511 DIRAS1 DIRAS family GTPase 1 2 2
MIRT718698 BTBD9 BTB domain containing 9 2 2
MIRT719578 TYRO3 TYRO3 protein tyrosine kinase 2 2
MIRT720892 CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 2 2
MIRT722633 C8A complement C8 alpha chain 2 2
MIRT723333 DGAT1 diacylglycerol O-acyltransferase 1 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-6871-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-6871-3p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-6871-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-6871-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)

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