pre-miRNA Information
pre-miRNA hsa-mir-6737   
Genomic Coordinates chr1: 153962351 - 153962420
Description Homo sapiens miR-6737 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6737-5p
Sequence 6| UUGGGGUGGUCGGCCCUGGAG |26
Evidence Experimental
Experiments Meta-analysis
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs766338599 4 dbSNP
rs765728788 7 dbSNP
rs757341439 9 dbSNP
rs539511149 11 dbSNP
rs764259486 12 dbSNP
rs988937601 21 dbSNP
Putative Targets

Gene Information
Gene Symbol DNAJC8   
Synonyms HSPC331, SPF31
Description DnaJ heat shock protein family (Hsp40) member C8
Transcript NM_014280   
Expression
Putative miRNA Targets on DNAJC8
3'UTR of DNAJC8
(miRNA target sites are highlighted)
>DNAJC8|NM_014280|3'UTR
   1 CCGCCCAAGGTCACAGGCACAGAACCTTTCCCCTGCTATCTCCCTTCCTGCTTCGAAGGACTCATTCTTTCCTCCCACTT
  81 CCACCCCAACATAGAGTAGTATTTGCTTTTTAGTCCATTTTGTTTTCAATACGATTTAATATCGATCAGAGTAATTCTTT
 161 TGTACATTGAAATGAGGGGCTTGGTTTAAAAAAAGACCTTTCCCTCTCCCTGCCCCTAGAACAACCAGTATTAGAAGGTG
 241 CCACCATTGGTGCTGCCTTCTCTTCCCACAGCCTGTAACTCAGTGTTTTGTACTTCACTGAATTGTGATGGTTAGAAACT
 321 TCGTGGATAGTTTGTGGAAATCATCCAATTAAACATACTGCTTAAAACAGTGTTGCTGTGACTTCAGAGACAAGCCTGGA
 401 AGGGGCACCTTAGGAAGCCCCTTCGCTTCAGTTGCTCGCTTCTGGGTGTGCTCCCTTCGAAGGCCCAGATAAGACAGGGA
 481 ACACTTGTGAGCACACAGAGCAGCATCTGATGCCCTGTGGTGTTTGGCATGTGCCCCCTGTCTACTGACCAATCAGTGTG
 561 GCATGAGGCCCACGCCACCCAAACCTTTCACTTTCCAAAGAGCTAGCCGTCCTCCACCCAGTACCATGTCCTAGCCTGTC
 641 TGCATTTGTTAGTGGTAATATTCTTTATGTATAATAAATTTTTATACCCAAGCCATTGATGTACTTTTCCTTGTACTCTC
 721 CCTTGTGGGTCCCTTGTCTGGCTTGGCTGAACCCCAAAATGCTTTGGGGTTGGACAGACCTGGCTGAACCTTAGTTTCTT
 801 CATCTATGAAATGGGAATATGAATTACTGCAGCAGCTTTTAGGGCAGATTTGCCATGGCATATACAAGGTAACTACCATA
 881 GTGCTCCTTGGGTATTGCCAATATCCTATTATTTCTGTGTAAAATGAAGATACTGATTGTTTTGAGGATTAAATGAAGTA
 961 ATATATGAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' gaggucccggcuGGUGGGGUu 5'
                      |||||||| 
Target 5' ttcctcccacttCCACCCCAa 3'
69 - 89 145.00 -21.10
2
miRNA  3' gaggucCCGGCUGGUGGGGUu 5'
                |||:||  |||||| 
Target 5' tggcttGGCTGA--ACCCCAa 3'
739 - 757 130.00 -20.30
3
miRNA  3' gaggUCCCGG-CUGGUGGGGUu 5'
              ||| ||  :|||||| | 
Target 5' catgAGGCCCACGCCACCCAAa 3'
562 - 583 125.00 -18.22
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30487941 33 COSMIC
COSN31546173 43 COSMIC
COSN30143046 54 COSMIC
COSN30124277 58 COSMIC
COSN26556516 84 COSMIC
COSN26550146 90 COSMIC
COSN31560273 128 COSMIC
COSN31612354 132 COSMIC
COSN31600518 133 COSMIC
COSN31580849 136 COSMIC
COSN31537589 175 COSMIC
COSN31503688 178 COSMIC
COSN31536317 213 COSMIC
COSN30312194 234 COSMIC
COSN1442541 315 COSMIC
COSM6897542 638 COSMIC
COSN26665492 671 COSMIC
COSN26667439 678 COSMIC
COSN26564970 704 COSMIC
COSN28676519 748 COSMIC
COSN22709746 890 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs777642919 1 dbSNP
rs370942935 2 dbSNP
rs1364079001 3 dbSNP
rs1270686931 7 dbSNP
rs773537189 11 dbSNP
rs1398863454 14 dbSNP
rs748098606 15 dbSNP
rs781343972 17 dbSNP
rs1434899808 19 dbSNP
rs576452091 20 dbSNP
rs754951090 25 dbSNP
rs201063813 26 dbSNP
rs1348652560 30 dbSNP
rs200774904 31 dbSNP
rs1193498370 32 dbSNP
rs757522302 38 dbSNP
rs531182164 40 dbSNP
rs753949516 42 dbSNP
rs564024593 44 dbSNP
rs754226248 46 dbSNP
rs764524776 46 dbSNP
rs1188945269 48 dbSNP
rs764515963 50 dbSNP
rs1266763758 54 dbSNP
rs184086871 55 dbSNP
rs770294979 74 dbSNP
rs944472320 75 dbSNP
rs919106138 77 dbSNP
rs1288214463 85 dbSNP
rs912945523 89 dbSNP
rs1246104899 90 dbSNP
rs35570191 90 dbSNP
rs1215097012 91 dbSNP
rs1488526768 94 dbSNP
rs1221361823 99 dbSNP
rs8678 105 dbSNP
rs1344011157 113 dbSNP
rs139274022 122 dbSNP
rs1264293846 127 dbSNP
rs1283268332 129 dbSNP
rs147272528 132 dbSNP
rs1342896626 133 dbSNP
rs1299523107 136 dbSNP
rs1308857677 141 dbSNP
rs956864396 144 dbSNP
rs925579536 147 dbSNP
rs1176324595 149 dbSNP
rs939139442 150 dbSNP
rs143936244 154 dbSNP
rs927697971 165 dbSNP
rs1363728385 166 dbSNP
rs138121284 177 dbSNP
rs191748539 190 dbSNP
rs1265181868 194 dbSNP
rs915511868 196 dbSNP
rs989715419 197 dbSNP
rs1485582993 199 dbSNP
rs746557361 204 dbSNP
rs1212485685 210 dbSNP
rs1321911220 214 dbSNP
rs1262947651 219 dbSNP
rs1291819378 226 dbSNP
rs1463759749 233 dbSNP
rs956940837 238 dbSNP
rs1031619989 243 dbSNP
rs1371375596 244 dbSNP
rs114065436 246 dbSNP
rs965847466 256 dbSNP
rs1212355608 262 dbSNP
rs1802449 264 dbSNP
rs568855403 268 dbSNP
rs1303114407 269 dbSNP
rs771688424 276 dbSNP
rs1004757217 279 dbSNP
rs1335865289 296 dbSNP
rs1465891948 308 dbSNP
rs887590997 312 dbSNP
rs779067310 318 dbSNP
rs1168219487 322 dbSNP
rs1428048227 323 dbSNP
rs552202690 324 dbSNP
rs1183637592 328 dbSNP
rs17163970 334 dbSNP
rs9447 348 dbSNP
rs1207833158 354 dbSNP
rs1199665599 355 dbSNP
rs1308980678 359 dbSNP
rs546835925 360 dbSNP
rs1217896911 378 dbSNP
rs1451252187 380 dbSNP
rs1250180405 387 dbSNP
rs1315555675 391 dbSNP
rs1227307619 403 dbSNP
rs1294648062 405 dbSNP
rs183137697 406 dbSNP
rs1312848000 407 dbSNP
rs1036610418 415 dbSNP
rs891582917 417 dbSNP
rs939167359 419 dbSNP
rs11538304 423 dbSNP
rs561280143 424 dbSNP
rs1044769404 425 dbSNP
rs947790297 429 dbSNP
rs1170629435 431 dbSNP
rs768065187 437 dbSNP
rs914939028 438 dbSNP
rs1204711115 442 dbSNP
rs1165837091 445 dbSNP
rs1423307520 446 dbSNP
rs1411920035 452 dbSNP
rs1802450 456 dbSNP
rs989098067 458 dbSNP
rs760009728 459 dbSNP
rs548292505 464 dbSNP
rs1248817996 469 dbSNP
rs1195550855 473 dbSNP
rs1197757490 479 dbSNP
rs1489106047 480 dbSNP
rs948305095 485 dbSNP
rs1356626771 487 dbSNP
rs531687079 490 dbSNP
rs916802650 492 dbSNP
rs562749941 496 dbSNP
rs1320528853 501 dbSNP
rs1230342196 509 dbSNP
rs1304633121 512 dbSNP
rs965543445 514 dbSNP
rs748979600 516 dbSNP
rs1225071504 527 dbSNP
rs1018790881 529 dbSNP
rs772670881 532 dbSNP
rs754773132 536 dbSNP
rs1015039688 539 dbSNP
rs1380103800 540 dbSNP
rs983521526 540 dbSNP
rs1445025152 543 dbSNP
rs1397400981 544 dbSNP
rs1357010036 548 dbSNP
rs11538303 549 dbSNP
rs769480841 552 dbSNP
rs760832249 556 dbSNP
rs545858979 557 dbSNP
rs756638785 557 dbSNP
rs576947870 561 dbSNP
rs1434057462 563 dbSNP
rs1270171602 567 dbSNP
rs749166804 568 dbSNP
rs560291622 571 dbSNP
rs746894128 573 dbSNP
rs779064448 574 dbSNP
rs1210284707 577 dbSNP
rs1487889526 578 dbSNP
rs1263109613 580 dbSNP
rs1027509337 584 dbSNP
rs995984660 588 dbSNP
rs1354060217 589 dbSNP
rs1258516819 595 dbSNP
rs1308064592 596 dbSNP
rs1238151657 602 dbSNP
rs1312538981 605 dbSNP
rs1238450669 606 dbSNP
rs540458806 607 dbSNP
rs199732438 608 dbSNP
rs1302627190 609 dbSNP
rs1344751614 611 dbSNP
rs1386656859 612 dbSNP
rs555289333 613 dbSNP
rs1192597688 616 dbSNP
rs1476934869 624 dbSNP
rs1389178659 626 dbSNP
rs1290753074 635 dbSNP
rs753950688 651 dbSNP
rs1360193727 656 dbSNP
rs190113790 660 dbSNP
rs1014817025 661 dbSNP
rs1009021516 663 dbSNP
rs1396615296 666 dbSNP
rs572368053 671 dbSNP
rs1199513108 672 dbSNP
rs1432569682 673 dbSNP
rs1265139978 677 dbSNP
rs1187825090 678 dbSNP
rs1431866540 680 dbSNP
rs1488299767 684 dbSNP
rs556116425 687 dbSNP
rs764283757 688 dbSNP
rs1213961264 689 dbSNP
rs1193285859 699 dbSNP
rs756309322 700 dbSNP
rs1448222171 703 dbSNP
rs1257005645 704 dbSNP
rs753103833 710 dbSNP
rs1329928459 713 dbSNP
rs1298354811 719 dbSNP
rs575134603 720 dbSNP
rs1264801176 723 dbSNP
rs1339850400 728 dbSNP
rs756108488 732 dbSNP
rs1322749036 736 dbSNP
rs1416798068 737 dbSNP
rs760054673 738 dbSNP
rs111937777 741 dbSNP
rs1049504 748 dbSNP
rs538707143 749 dbSNP
rs935768862 752 dbSNP
rs1465350509 757 dbSNP
rs1375874654 761 dbSNP
rs1396859555 764 dbSNP
rs904239986 768 dbSNP
rs1356872570 772 dbSNP
rs1408510134 774 dbSNP
rs1044289925 775 dbSNP
rs893553420 778 dbSNP
rs765920785 779 dbSNP
rs767545167 780 dbSNP
rs762439287 782 dbSNP
rs1425060408 784 dbSNP
rs775727652 789 dbSNP
rs948237557 790 dbSNP
rs1200298936 791 dbSNP
rs1343239488 795 dbSNP
rs1370808381 796 dbSNP
rs1053386753 798 dbSNP
rs1188765454 802 dbSNP
rs757543826 806 dbSNP
rs1461505332 812 dbSNP
rs924198707 814 dbSNP
rs977004626 815 dbSNP
rs140371614 821 dbSNP
rs1258695910 828 dbSNP
rs1197454538 843 dbSNP
rs148276460 846 dbSNP
rs985625848 847 dbSNP
rs1245539569 852 dbSNP
rs1385274680 854 dbSNP
rs536500767 855 dbSNP
rs1267637114 857 dbSNP
rs1452445878 860 dbSNP
rs1401449125 862 dbSNP
rs983428358 864 dbSNP
rs952111263 868 dbSNP
rs567354173 870 dbSNP
rs1027040261 875 dbSNP
rs1027706189 885 dbSNP
rs973159295 886 dbSNP
rs975017704 887 dbSNP
rs964576113 892 dbSNP
rs1181355412 896 dbSNP
rs1443822484 898 dbSNP
rs144916962 901 dbSNP
rs1244259721 908 dbSNP
rs1183661807 912 dbSNP
rs781056642 921 dbSNP
rs1436023067 922 dbSNP
rs1272126471 928 dbSNP
rs1019304832 933 dbSNP
rs1361669633 939 dbSNP
rs184914634 957 dbSNP
rs576792323 959 dbSNP
rs751900423 963 dbSNP
rs1008757653 966 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 22826.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM1065667. RNA binding protein: AGO1. Condition:4-thiouridine ...

- Memczak S; Jens M; Elefsinioti A; Torti F; et al., 2013, Nature.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' gaggucccggcuGGUGGGGUu 5'
                      |||||||| 
Target 5' uuccucccacuuCCACCCCAa 3'
10 - 30
2
miRNA  3' gaggucccggcuggUGGGguu 5'
                        ||:|   
Target 5' --------------ACUCauu 3'
1 - 7
Article - Memczak S; Jens M; Elefsinioti A; Torti F; et al.
- Nature, 2013
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.
LinkOut: [PMID: 23446348]
CLIP-seq Support 1 for dataset GSM1065667
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / 4-thiouridine, ML_MM_6
Location of target site ENST00000263697.4 | 3UTR | ACUCAUUCUUUCCUCCCACUUCCACCCCAACAUAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
67 hsa-miR-6737-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT066215 MARCH9 membrane associated ring-CH-type finger 9 2 2
MIRT074413 TNRC6A trinucleotide repeat containing 6A 2 2
MIRT125300 MID1IP1 MID1 interacting protein 1 2 2
MIRT153951 NCOA3 nuclear receptor coactivator 3 2 2
MIRT452776 FAM136A family with sequence similarity 136 member A 2 2
MIRT452977 CABP4 calcium binding protein 4 2 2
MIRT454128 FOXRED2 FAD dependent oxidoreductase domain containing 2 2 2
MIRT455242 DDX39B DExD-box helicase 39B 2 10
MIRT459007 UQCRH ubiquinol-cytochrome c reductase hinge protein 2 2
MIRT459463 MUC17 mucin 17, cell surface associated 2 4
MIRT460871 UBE2S ubiquitin conjugating enzyme E2 S 2 2
MIRT461264 COX10 COX10, heme A:farnesyltransferase cytochrome c oxidase assembly factor 2 2
MIRT464540 UBTF upstream binding transcription factor, RNA polymerase I 2 2
MIRT465268 TRIM28 tripartite motif containing 28 2 2
MIRT465871 TMEM43 transmembrane protein 43 2 4
MIRT466228 TMED10 transmembrane p24 trafficking protein 10 2 2
MIRT468417 SETD1B SET domain containing 1B 2 2
MIRT468684 SEC22C SEC22 homolog C, vesicle trafficking protein 2 4
MIRT473399 MDM4 MDM4, p53 regulator 2 2
MIRT473517 MAX MYC associated factor X 2 2
MIRT474511 KLHDC8A kelch domain containing 8A 2 2
MIRT475801 HDGF heparin binding growth factor 2 2
MIRT479493 CDH6 cadherin 6 2 2
MIRT480770 BMP2 bone morphogenetic protein 2 2 2
MIRT481418 ASB6 ankyrin repeat and SOCS box containing 6 2 2
MIRT482966 CSTF2 cleavage stimulation factor subunit 2 2 2
MIRT483380 SPATA6 spermatogenesis associated 6 2 4
MIRT483677 CYP11A1 cytochrome P450 family 11 subfamily A member 1 2 2
MIRT484328 EPN1 epsin 1 2 4
MIRT484963 UCK1 uridine-cytidine kinase 1 2 2
MIRT485908 PGPEP1 pyroglutamyl-peptidase I 2 4
MIRT488149 PRRC2B proline rich coiled-coil 2B 2 4
MIRT488943 CYP2W1 cytochrome P450 family 2 subfamily W member 1 2 6
MIRT491835 ZBTB7A zinc finger and BTB domain containing 7A 2 4
MIRT493026 NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit 2 2
MIRT499374 PLCG2 phospholipase C gamma 2 2 11
MIRT499723 USH1G USH1 protein network component sans 2 4
MIRT500349 ZNF385A zinc finger protein 385A 2 2
MIRT509574 HIST2H2AB histone cluster 2 H2A family member b 2 4
MIRT512794 GLRX glutaredoxin 2 2
MIRT513291 SETBP1 SET binding protein 1 2 2
MIRT515697 ZNF321P zinc finger protein 321, pseudogene 2 2
MIRT518255 LEAP2 liver enriched antimicrobial peptide 2 2 2
MIRT522026 PAQR3 progestin and adipoQ receptor family member 3 2 4
MIRT523169 HIST3H3 histone cluster 3 H3 2 2
MIRT524036 DNAJC8 DnaJ heat shock protein family (Hsp40) member C8 2 2
MIRT533476 TRIM71 tripartite motif containing 71 2 2
MIRT541488 ADM adrenomedullin 2 2
MIRT553987 SRPR SRP receptor alpha subunit 2 2
MIRT571445 YKT6 YKT6 v-SNARE homolog 2 2
MIRT574889 Plcg2 phospholipase C, gamma 2 2 7
MIRT607544 GLI2 GLI family zinc finger 2 2 2
MIRT607688 MAPK10 mitogen-activated protein kinase 10 2 2
MIRT610072 CRLF1 cytokine receptor like factor 1 2 2
MIRT610573 CACUL1 CDK2 associated cullin domain 1 2 2
MIRT614041 THBS2 thrombospondin 2 2 2
MIRT626318 LRTOMT leucine rich transmembrane and O-methyltransferase domain containing 2 2
MIRT634005 RIF1 replication timing regulatory factor 1 2 2
MIRT639619 FGF19 fibroblast growth factor 19 2 2
MIRT647343 RPH3AL rabphilin 3A like (without C2 domains) 2 2
MIRT689704 ATXN2 ataxin 2 2 2
MIRT691170 APOL6 apolipoprotein L6 2 2
MIRT693165 NPR1 natriuretic peptide receptor 1 2 2
MIRT711727 NUPL2 nucleoporin like 2 2 2
MIRT711806 ELN elastin 2 2
MIRT721546 FXN frataxin 2 2
MIRT722979 GDE1 glycerophosphodiester phosphodiesterase 1 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-6737 Ceritinib 57379345 NSC776422 approved sensitive High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-6737 Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)
hsa-miR-6737-5p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-6737-5p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-6737-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-6737-5p Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-6737-5p Paclitaxel 36314 NSC125973 approved resistant cell line (A2780)
hsa-miR-6737-5p Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)
hsa-miR-6737-5p Docetaxel+Cisplatin+5-Fluorouracil resistant tissue (hypopharyngeal squamous cell carcinoma)

Error report submission