pre-miRNA Information | |
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pre-miRNA | hsa-mir-6839 |
Genomic Coordinates | chr7: 64679064 - 64679176 |
Description | Homo sapiens miR-6839 stem-loop |
Comment | None |
RNA Secondary Structure |
Mature miRNA Information | |||||||||||||
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Mature miRNA | hsa-miR-6839-3p | ||||||||||||
Sequence | 92| UUGGGUUUUCUCUUCAAUCCAG |113 | ||||||||||||
Evidence | Experimental | ||||||||||||
Experiments | Meta-analysis | DRVs in miRNA |
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SNPs in miRNA |
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Putative Targets |
miRNA Expression profile | |
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miRNAs in Extracellular Vesicles |
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Circulating MicroRNA Expression Profiling |
Gene Information | |||||||||||||||||||||
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Gene Symbol | DMXL1 | ||||||||||||||||||||
Synonyms | - | ||||||||||||||||||||
Description | Dmx like 1 | ||||||||||||||||||||
Transcript | NM_005509 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on DMXL1 | |||||||||||||||||||||
3'UTR of DMXL1 (miRNA target sites are highlighted) |
>DMXL1|NM_005509|3'UTR 1 CATTTTTACAATAAGATGTACAATTTATTACCTATATGGAAGTGGCCAACAGATATAATATACAGTGATCATTCTCTATG 81 CCACAAATTAGCTAATGCTTTCTTGTTTTTATATTTATTTTATGGAGCTTTGCCCTTGATGCACTGATGCCTTAAAAATT 161 AACAAGGTCATTCAGAAGTAGATTACATTGCCTAAAGTAGAATGTGTAAGTAATGCTGTAATAATACATATCATAGTATA 241 TTATAATCAGTATGTCATAGTGTTAAAGGTGTTTTGTTTTCTTATTGATACTTTTCCACAGGCATCTCTGCATGAATTTC 321 TTCCACAGTAAAAATACGTTTTTTGTAAAGGCAATTGTACATAATACTCATCACTTAATTCACCACACTCTCACTTCCTT 401 TATTAGCCTTATACATCTCAAACTCTTCTCTTAATTAATGATAGGTATTTGAGTAAGAATGAAAAAAATAATGAACATCT 481 TCATTAAAATTGTCATTGAGACGTCAGTGATAAATGAGCTAGATGGCTCAATATGTAAGGTTTTCAGTAGTTTACCCTCC 561 GGAACCCAAGTTGTATGTATGTATACGTGTGTGTGTGTGTGTGTGTGTGTATCTTACACATCTTATTTGAACTTAGTTGT 641 ATATATTAGCGAAAACTGGTTTTTCATGTGTTTTTGTGCCATAACAACTATTGCCACCAGAATAACTTTTTTTTTGCAAC 721 TGTGCTTTTCATTTTTAAAAAATTTTTGAATTCCCATCCTAATTTTCAAATAAGTTTCAAGGAGACTATCAGGATTATTA 801 TTTTAAAGATTAGATTTAGTCAAATAAGTCTTAGCAGGCAATAAAGTTTCTGTGGTGGCATATATCATGTAAGACACTTA 881 AAGTAAGTTTGTGAATTTGTCAACTTTCGAGCATCAAACAAATATTTTACTTAAATTTTATTTTATCTTATTTTTAGGTG 961 CTTTTAATCTCAAAATTCTGAAAAGCGAATAGCAGTGTTTTCAGAAACAAATGTGAAAGCAGTCAAATTAAGTAGATACT 1041 ATTTAGAAATGTAAAATACTCTCCAGATCTACCATTAATAGAAAATAAACTAAACCTTATATTTTATTTTTGCCAAAATA 1121 TTTTATTATAAAATATGACCAAAATATTTAAAATGCACAATGCTTTTAACTTAAATGTGCTAACCCTGTTTCTGTCTGTT 1201 TTGTGCTGTACCTTTTCTGATTCAGAATTATAGAAAACTTGATAAATACTTGATTTTAACCAATGAGACTACAGGCAGAT 1281 GGGACTAAGTGTTTATGGGACAATTATGTACTATTTAACTTAAATATATTTTGTTTAATAGGAAATATATAATAATAGCA 1361 TTTTATGTAATAAAATATGGGCAACGATTATCTTGGAAATTAAAGAGTCAAAGCAAAGAAATGAAGGGCTGGTAAAATGA 1441 ATTTTGTAATATCCTCAGGATACTTTTATCTTAAAAGTATGTTGTTAAAGATTTTGTAAATTGTATTTCAACAATTTTAA 1521 ATGTGTTGAGCAAGTTGCAGTGCAAACACTGTCATTATGTAGAGAGTTTATATGCACATAATAACCTGTACCTATAAATC 1601 GTGCAATAACCATATGCGACTATTTTGCCATGGAGAAATCTGACAGCATTGCAAACAATAGTATTGTTTGATGTAGTTAA 1681 CCTTAAGTTATTTTTCAGTAATTTCTTCACAAATCAAGATTCAAACAGCTTTAAACACTTCCAATGAGATAAAATATTTA 1761 CTATTATGCTTATTAGAACAAAAGGTGTTTAAGGATGAACTAAATATTTTAATTGAGCATTTATATGGATAATCATACAT 1841 TATGTAAGCCCATATGTATTTACATCCAGAGTCATAATATTTTAAATAAACAATCATGCAGAAACTTTTTAAAAAAAAA Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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DRVs in gene 3'UTRs | |||||||||||||||||||||
SNPs in gene 3'UTRs |
Experimental Support 1 for Functional miRNA-Target Interaction | |||||||
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miRNA:Target | ---- | ||||||
Validation Method |
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Conditions | HEK293 | ||||||
Disease | 1657.0 | ||||||
Location of target site | 3'UTR | ||||||
Tools used in this research | TargetScan , miRTarCLIP , Piranha | ||||||
Original Description (Extracted from the article) |
...
"PAR-CLIP data was present in GSM1065667. RNA binding protein: AGO1. Condition:4-thiouridine
... - Memczak S; Jens M; Elefsinioti A; Torti F; et al., 2013, Nature. |
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miRNA-target interactions (Provided by authors) |
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Article |
- Memczak S; Jens M; Elefsinioti A; Torti F; et al. - Nature, 2013
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.
LinkOut: [PMID: 23446348]
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CLIP-seq Support 1 for dataset GSM1065667 | |
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Method / RBP | PAR-CLIP / AGO1 |
Cell line / Condition | HEK293 / 4-thiouridine, ML_MM_6 |
Location of target site | ENST00000311085.8 | 3UTR | UGGCCAACAUGGUGAAACCCAUCUCUACUAAAAAUACAAAAAUUAGUGG |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23446348 / GSE43573 |
CLIP-seq Viewer | Link |
MiRNA-Target Expression Profile | |||||||
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MiRNA-Target Expression Profile (TCGA) | |||||||
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62 hsa-miR-6839-3p Target Genes:
Functional analysis:
ID | Target | Description | Validation methods | |||||||||
Strong evidence | Less strong evidence | |||||||||||
MIRT059162 | TXNIP | thioredoxin interacting protein | 2 | 2 | ||||||||
MIRT064872 | ZBTB18 | zinc finger and BTB domain containing 18 | 2 | 2 | ||||||||
MIRT065802 | HOXC8 | homeobox C8 | 2 | 4 | ||||||||
MIRT106005 | SDCBP | syndecan binding protein | 2 | 2 | ||||||||
MIRT275773 | TFDP1 | transcription factor Dp-1 | 2 | 2 | ||||||||
MIRT314032 | PAPD7 | poly(A) RNA polymerase D7, non-canonical | 2 | 2 | ||||||||
MIRT360277 | HIST1H2BE | histone cluster 1 H2B family member e | 2 | 8 | ||||||||
MIRT360301 | HIST1H2BH | histone cluster 1 H2B family member h | 2 | 2 | ||||||||
MIRT450086 | OR2A4 | olfactory receptor family 2 subfamily A member 4 | 2 | 2 | ||||||||
MIRT468815 | RSRC2 | arginine and serine rich coiled-coil 2 | 2 | 6 | ||||||||
MIRT475093 | IRF2BP2 | interferon regulatory factor 2 binding protein 2 | 2 | 4 | ||||||||
MIRT477575 | EIF1AD | eukaryotic translation initiation factor 1A domain containing | 2 | 2 | ||||||||
MIRT483926 | LCORL | ligand dependent nuclear receptor corepressor like | 2 | 6 | ||||||||
MIRT504381 | HIST1H1C | histone cluster 1 H1 family member c | 2 | 4 | ||||||||
MIRT506970 | HNRNPUL1 | heterogeneous nuclear ribonucleoprotein U like 1 | 2 | 6 | ||||||||
MIRT507028 | HIST1H3B | histone cluster 1 H3 family member b | 2 | 6 | ||||||||
MIRT511561 | HIST3H2BB | histone cluster 3 H2B family member b | 2 | 4 | ||||||||
MIRT511650 | HIST1H3D | histone cluster 1 H3 family member d | 2 | 6 | ||||||||
MIRT511696 | HIST1H2BL | histone cluster 1 H2B family member l | 2 | 4 | ||||||||
MIRT511737 | HIST1H2BB | histone cluster 1 H2B family member b | 2 | 6 | ||||||||
MIRT511746 | HIST1H2BA | histone cluster 1 H2B family member a | 2 | 8 | ||||||||
MIRT515260 | CSNK1E | casein kinase 1 epsilon | 2 | 2 | ||||||||
MIRT516220 | RAB3B | RAB3B, member RAS oncogene family | 2 | 4 | ||||||||
MIRT523281 | HIST1H1E | histone cluster 1 H1 family member e | 2 | 2 | ||||||||
MIRT524121 | DMXL1 | Dmx like 1 | 2 | 2 | ||||||||
MIRT530744 | GPR82 | G protein-coupled receptor 82 | 2 | 2 | ||||||||
MIRT532214 | CCDC117 | coiled-coil domain containing 117 | 2 | 2 | ||||||||
MIRT546182 | TPRG1L | tumor protein p63 regulated 1 like | 2 | 2 | ||||||||
MIRT558638 | CNNM2 | cyclin and CBS domain divalent metal cation transport mediator 2 | 2 | 2 | ||||||||
MIRT559562 | ARF1 | ADP ribosylation factor 1 | 2 | 4 | ||||||||
MIRT560680 | HIST1H1T | histone cluster 1 H1 family member t | 2 | 2 | ||||||||
MIRT570746 | AAK1 | AP2 associated kinase 1 | 2 | 2 | ||||||||
MIRT609518 | RAB3IP | RAB3A interacting protein | 2 | 2 | ||||||||
MIRT612583 | SYNGAP1 | synaptic Ras GTPase activating protein 1 | 2 | 4 | ||||||||
MIRT615733 | RIOK3 | RIO kinase 3 | 2 | 2 | ||||||||
MIRT616068 | SIX1 | SIX homeobox 1 | 2 | 2 | ||||||||
MIRT617903 | SGCD | sarcoglycan delta | 2 | 2 | ||||||||
MIRT620851 | SERPING1 | serpin family G member 1 | 2 | 2 | ||||||||
MIRT625107 | SLC1A5 | solute carrier family 1 member 5 | 2 | 2 | ||||||||
MIRT625120 | NUP93 | nucleoporin 93 | 2 | 2 | ||||||||
MIRT625893 | LINC00632 | long intergenic non-protein coding RNA 632 | 2 | 2 | ||||||||
MIRT626569 | MED7 | mediator complex subunit 7 | 2 | 2 | ||||||||
MIRT626694 | ZFP14 | ZFP14 zinc finger protein | 2 | 4 | ||||||||
MIRT626808 | PRR11 | proline rich 11 | 2 | 2 | ||||||||
MIRT628131 | HM13 | histocompatibility minor 13 | 2 | 2 | ||||||||
MIRT636596 | DCAF5 | DDB1 and CUL4 associated factor 5 | 2 | 2 | ||||||||
MIRT649866 | SLFN12L | schlafen family member 12 like | 2 | 2 | ||||||||
MIRT652133 | TRPM7 | transient receptor potential cation channel subfamily M member 7 | 2 | 2 | ||||||||
MIRT652663 | TIMELESS | timeless circadian clock | 2 | 2 | ||||||||
MIRT658335 | FAM83D | family with sequence similarity 83 member D | 2 | 2 | ||||||||
MIRT660615 | ANKS4B | ankyrin repeat and sterile alpha motif domain containing 4B | 2 | 2 | ||||||||
MIRT666304 | SLC22A3 | solute carrier family 22 member 3 | 2 | 2 | ||||||||
MIRT668528 | ERGIC2 | ERGIC and golgi 2 | 2 | 2 | ||||||||
MIRT692510 | PARD3 | par-3 family cell polarity regulator | 2 | 2 | ||||||||
MIRT694784 | DHFRL1 | dihydrofolate reductase 2 | 2 | 2 | ||||||||
MIRT700510 | PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 2 | 2 | ||||||||
MIRT701438 | NFYA | nuclear transcription factor Y subunit alpha | 2 | 2 | ||||||||
MIRT710155 | MTRF1L | mitochondrial translational release factor 1 like | 2 | 2 | ||||||||
MIRT711436 | DLC1 | DLC1 Rho GTPase activating protein | 2 | 2 | ||||||||
MIRT716979 | GPR155 | G protein-coupled receptor 155 | 2 | 2 | ||||||||
MIRT720155 | POU2F2 | POU class 2 homeobox 2 | 2 | 2 | ||||||||
MIRT722512 | DSTYK | dual serine/threonine and tyrosine protein kinase | 2 | 2 |