pre-miRNA Information | |
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pre-miRNA | hsa-mir-4260 |
Genomic Coordinates | chr1: 209623444 - 209623510 |
Description | Homo sapiens miR-4260 stem-loop |
Comment | None |
RNA Secondary Structure | ![]() |
Mature miRNA Information | |||||||||||||
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Mature miRNA | hsa-miR-4260 | ||||||||||||
Sequence | 11| CUUGGGGCAUGGAGUCCCA |29 | ||||||||||||
Evidence | Experimental | ||||||||||||
Experiments | SOLiD | DRVs in miRNA |
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SNPs in miRNA |
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Putative Targets |
miRNA Expression profile | |
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Human miRNA Tissue Atlas | |
Circulating MicroRNA Expression Profiling |
Gene Information | |||||||||||||||||||||
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Gene Symbol | BAG5 | ||||||||||||||||||||
Synonyms | BAG-5 | ||||||||||||||||||||
Description | BCL2 associated athanogene 5 | ||||||||||||||||||||
Transcript | NM_001015048 | ||||||||||||||||||||
Other Transcripts | NM_001015049 , NM_004873 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on BAG5 | |||||||||||||||||||||
3'UTR of BAG5 (miRNA target sites are highlighted) |
>BAG5|NM_001015048|3'UTR 1 AATACCAGAGATCTCACTTTTGATACTGTTTTGCACTTCATATGTGCTTCTATGTATAGAGAGCTTTCAGTTCATTGATT 81 TATACGTGCATATTTCAGTCTCAGTATTTATGATTGAAGCAAATTCTATTCAGTATCTGCTGCTTTTGATGTTGCAAGAC 161 AAATATCATTACAGCACGTTAACTTTTCCATTCGGATCATTATCTGTATGATGTGGTGTGGTTTGTTTGGTTTGTCCTTT 241 TTTTTGCGTTTTTAATCAGAAAACAAAATAGAGGCAGCTTTTGTAGATTTTAAATGGGTTGTGCAAGCATTAAAATGCAG 321 GTCTTTCAGAATCTAGAACTAGGCATAACCTTACATAATACTAGGAAAATTATGAGAAAGGGGAAATTTTTGGTTAAATA 401 AGAGTAAGGTTCAAACACAAGCAGTACATGTTCTGTTTCATTATGCTCGATAGAAGGCTTTTTTTTCACTTATAAGGCCT 481 GATTGGTCCTACCCAGCTTAACGGGGTGGGGTTTTTTTGTTTGTTCAGACAGTCTGTTCTTTTGTAAACATTTTTAGTTG 561 GAAAAACAGCATCTGCATTTTCCCCATCCTCTACGTTTTAGAGAGGAATCTTGTTTTTGTGTGCAACATAAGAAAATTAT 641 GAAAACTAATAGCCAAAAAACCTTTGAGATTGCATTAAAGAGAAGGGATAAAGGACCAGCAATAATACCTTGTAAGTTGC 721 TTTTGTTTGTAAAATCTGAGCTTATAGTTTTCCTTAGTGAGTAAATTCATAAGGATGGGAACATTTAAATTAAGTTAATG 801 GGCCTTTAAAAAAAAAAAAAGGAAACACTCATACCTGTAGTTGGAGGATGAATACTGGAGACGGGTTACCAATGTCAGGT 881 TATACTAAAACTAAATCAGAAAGTCTGAATGTAGCACATAATGGTTCTCTTCTGTTGTCCAAGGCTGTAAAATGGACAGC 961 CTTGTCACACCTCCCCGGTGCTGTTTTACAACGTGAGGGTAGACGCTGTCAGTAACCCAGAGGGACCAGGCCTTCCTAGG 1041 TTTTCTAGGCAGTCAGCTGTTAACCACTCACTTAGTAAATGTCATAACTACACCTGCTCCAGGACCAATCAGTGAAACCT 1121 GCTCGGAATTAAAGGCTTCCTCTGGGTGCCTGCTGAACAACTGAGCTCATGTCATGGGCATGTGGTGGTTTCTCTGTTGC 1201 CTGAAAGAGCCATTAAAGTCAGTCGTGCGTGAAGCATCTCTCTTCTAAAGGATGTGTATTTCCATAAATGCTTTCTGAGG 1281 ATCCGGTACAAAATGATTTCCCAAAGTTCTGAAGTGCCTTGAGAACATGTGGGTCCGAGTGTTATAACAGACTCCTCCCC 1361 CGGGTCACCTTTTGCCTGGTCATCCTGTTAGAGTACATCTTTGGAAATCCAGGGTAATATTCTCTTTCAGAGATGCTCAT 1441 TGTGTAACTCTGTGTAGGGAGATAGTCACTTTAAACAGCTCAAAGTAGCTAGCTAAAGGAGTAGCCTTAAATACCTAAAA 1521 GATGACAGAAGCATAGCCCTTAACAAATCTTCAGCTTGTCTCTCAGTATTTCCCAATCATGAAAATCCCTTGCTATGTCT 1601 TTCCTACTAGAAATGTTCTAGAATCGCTGGACGGTGGGGTCAGAGGGCAGTCGGTATTTAGGCCGTGAGCTTCCCATACT 1681 ACTGCAGGTCCAACTCCTGGCAACCGCGGGCTCAAGGCAGGTCATTGGAATCCACGTTTTGGCCACAGTAGTTGTAGGAT 1761 TGCTTTTCTGTATCATAATTTTAGAATGCTCTTAAAATCTTGAGGAAGAGTTTTTATTTTTTATTTATTTTTGAGATGGA 1841 GTCTCTGTTGCCCAGGCTGCAGTGCAGTGGTGCCATCTCAGCTCACTGCAACCTCCACCTCCCAGGTTCAAGCGATTCTC 1921 CTGCCTCAGCCACCTGAGTAGCTGGGAGTACAGGCATGTGGCACCATGCCTGGCTAATTTTTGTATTTTTAATAGAGTTG 2001 AGATTTCACCATGATGGTCAGGCTGGTCTCGAACTCCTGACCTCGTGATCCGCCCGCCTCGGCCCCCCAAAGTGCTGGGA 2081 TTAACGGGTGTGAGCCACGGCGCCCAGCCCAGGAAGAGTTTTTAAATTAGAGCTCTGTTTAATTATACCACTGGGAAATC 2161 ATGGTTACGCTTCAGGCATATTCTTCCCCAGAGTACTACTTACATTTTAAATTTCATTTTGTAAAGTTAAATGTCAGCAT 2241 TCCCTTTAAAAGTGTCCATTGTTCTTTGAAAGTAGACGTTTCAGTCATTCTTTTCAAACAAGTGTTTGTGTACCTTTTGC 2321 CAAGCTGTGGGCATCGTGTGTGAGTACAGGGTGCTCAGCTCTTCCACCGTCATTTTGAATTGTTCACATGGGTAATTGGT 2401 CATGGAAATGATCAGATTGACCTTGATTGACTGTCAGGCATGGCTTTGTTTCTGGTTTCAATCTGTTCTCGTTCCTTGTA 2481 CCGGATTATTCTACTCCTGCAATGAACCCTGTTGACACCGGATTTAGCTCTTGTCGGCCTTCGTGGGGAGCTGTTTGTGT 2561 TAATATGAGCTACTGCATGTAATTCTTAAACTGGGCTTGTCACATTGTATTGTATTTTTGTGATCTGTAATGAAAAGAAT 2641 CTGTACTGCAAGTAAAACCTACTCCCCAAAAATGTGTGGCTTTGGGTCTGCATTAAACGCTGTAGTCCATGTTCATGCCA 2721 AAAATGGCTGGGAACGTTTGCTTTATTTACATTCAGTCAGCGTTGCTTTCAGATCACACTTTATCCACACAGGAAAGCCA 2801 GTCAGCCTATAATGAAGTAGTTATTAAAATAAATGTAATGAATATGTCTACAAAGTATAGTTTAGTGGTTTATTTTGCTA 2881 AAATGCACATATATTTGATATAATTTAGTTTGAGAAGTTCAGCTAGTTTTTCTCCTTTGTTTGACTTTGTCAATTTCTAT 2961 CTGGTTTTTAAGGGTCTGAGCTTAGCTTGTGCATGCAAGGTTTTGGGTTTTTTTATTTTTTTTTTGAGCACAGCTTTTCA 3041 CCTTTTAATTTGTTGGGTATTTTTCTCTTAATAAGAGAAATATTGGCCATCGATTTTTACATATAATACAAGTGTGTTTT 3121 TCCAGTACATTGGTTCCTGTCCCCTCTCTGTGAACTGTTTGAGTATTGGAACAGTATGTCTTCAATAATTCAATGTTACT 3201 TTGAGATACATGTGTTAATATACCCTTAGTTATTCTTGAAATAAAACCAGTCTCTTACGCTTGCAGTGGAGAAAGGCAAA 3281 AAAAAAAAAAAAAAA Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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DRVs in gene 3'UTRs | |||||||||||||||||||||
SNPs in gene 3'UTRs |
Experimental Support 1 for Functional miRNA-Target Interaction | |||||||
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miRNA:Target | ---- | ||||||
Validation Method |
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Conditions | HEK293 | ||||||
Disease | 9529.0 | ||||||
Location of target site | 3'UTR | ||||||
Tools used in this research | TargetScan , miRTarCLIP , Piranha | ||||||
Original Description (Extracted from the article) |
...
"PAR-CLIP data was present in GSM1065667. RNA binding protein: AGO1. Condition:4-thiouridine
... - Memczak S; Jens M; Elefsinioti A; Torti F; et al., 2013, Nature. |
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miRNA-target interactions (Provided by authors) |
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Article |
- Memczak S; Jens M; Elefsinioti A; Torti F; et al. - Nature, 2013
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.
LinkOut: [PMID: 23446348]
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CLIP-seq Support 1 for dataset GSM4903833 | |
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Method / RBP | HITS-CLIP / AGO |
Cell line / Condition | Dermal fibroblasts / CTL_TD_21_a |
Location of target site | NM_001015048 | 3UTR | UAAUUUUUGUAUUUUUAAUAGAGUUGAGAUUUCACCAUGAUGGUCAGGCUGGUCUCGAACUCCUGACCUCGUGAUCCGCCCGCCUCGGCCCCCCAAAGUGCUGGGAUUAACGG |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Accession Series | GSE161239 |
CLIP-seq Viewer | Link |
CLIP-seq Support 2 for dataset GSM4903834 | |
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Method / RBP | HITS-CLIP / AGO |
Cell line / Condition | Dermal fibroblasts / CTL_TD_21_b |
Location of target site | NM_001015048 | 3UTR | ACCAUGAUGGUCAGGCUGGUCUCGAACUCCUGACCUCGUGAUCCGCCCGCCUCGGCCCCCCAAAGUGCUGGGAUUAACGG |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Accession Series | GSE161239 |
CLIP-seq Viewer | Link |
CLIP-seq Support 3 for dataset GSM4903835 | |
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Method / RBP | HITS-CLIP / AGO |
Cell line / Condition | Dermal fibroblasts / CTL_TD_21_c |
Location of target site | NM_001015048 | 3UTR | UGAGAUUUCACCAUGAUGGUCAGGCUGGUCUCGAACUCCUGACCUCGUGAUCCGCCCGCCUCGGCCCCCCAAAGUGCUGGGAUUAACGG |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Accession Series | GSE161239 |
CLIP-seq Viewer | Link |
CLIP-seq Support 4 for dataset GSM4903836 | |
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Method / RBP | HITS-CLIP / AGO |
Cell line / Condition | Dermal fibroblasts / 124_TD_21_a |
Location of target site | NM_001015048 | 3UTR | CUAAUUUUUGUAUUUUUAAUAGAGUUGAGAUUUCACCAUGAUGGUCAGGCUGGUCUCGAACUCCUGACCUCGUGAUCCGCCCGCCUCGGCCCCCCAAAGUGCUGGGAUUAACGG |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Accession Series | GSE161239 |
CLIP-seq Viewer | Link |
CLIP-seq Support 5 for dataset GSM4903837 | |
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Method / RBP | HITS-CLIP / AGO |
Cell line / Condition | Dermal fibroblasts / 124_TD_21_b |
Location of target site | NM_001015048 | 3UTR | GUAUUUUUAAUAGAGUUGAGAUUUCACCAUGAUGGUCAGGCUGGUCUCGAACUCCUGACCUCGUGAUCCGCCCGCCUCGGCCCCCCAAAGUGCUGGGAUUAACGG |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Accession Series | GSE161239 |
CLIP-seq Viewer | Link |
CLIP-seq Support 6 for dataset GSM4903838 | |
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Method / RBP | HITS-CLIP / AGO |
Cell line / Condition | Dermal fibroblasts / 124_TD_21_c |
Location of target site | NM_001015048 | 3UTR | CCAUGAUGGUCAGGCUGGUCUCGAACUCCUGACCUCGUGAUCCGCCCGCCUCGGCCCCCCAAAGUGCUGGGAUUAACGG |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Accession Series | GSE161239 |
CLIP-seq Viewer | Link |
CLIP-seq Support 7 for dataset GSM1065667 | |
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Method / RBP | PAR-CLIP / AGO1 |
Cell line / Condition | HEK293 / 4-thiouridine, ML_MM_6 |
Location of target site | ENST00000299204.4 | 3UTR | AUCCGCCCGCCUCGGCCCCCCAAA |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23446348 / GSE43573 |
CLIP-seq Viewer | Link |
MiRNA-Target Expression Profile | |||||||
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MiRNA-Target Expression Profile (TCGA) | |||||||
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66 hsa-miR-4260 Target Genes:
Functional analysis:
ID![]() |
Target | Description | Validation methods |
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Strong evidence | Less strong evidence | |||||||||||
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MIRT074404 | TNRC6A | trinucleotide repeat containing 6A | ![]() |
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2 | 2 | ||||||
MIRT289774 | PER1 | period circadian clock 1 | ![]() |
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2 | 2 | ||||||
MIRT442576 | HOXD9 | homeobox D9 | ![]() |
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2 | 2 | ||||||
MIRT443878 | CNKSR3 | CNKSR family member 3 | ![]() |
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2 | 2 | ||||||
MIRT449080 | XPO6 | exportin 6 | ![]() |
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2 | 2 | ||||||
MIRT450294 | DRAXIN | dorsal inhibitory axon guidance protein | ![]() |
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2 | 2 | ||||||
MIRT461785 | FXR2 | FMR1 autosomal homolog 2 | ![]() |
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2 | 2 | ||||||
MIRT463931 | WNT10B | Wnt family member 10B | ![]() |
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2 | 2 | ||||||
MIRT464860 | UBB | ubiquitin B | ![]() |
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2 | 8 | ||||||
MIRT467619 | SLC7A5 | solute carrier family 7 member 5 | ![]() |
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2 | 2 | ||||||
MIRT469649 | RAC1 | Rac family small GTPase 1 | ![]() |
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2 | 2 | ||||||
MIRT473421 | MDM4 | MDM4, p53 regulator | ![]() |
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2 | 2 | ||||||
MIRT473646 | MARCKSL1 | MARCKS like 1 | ![]() |
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2 | 2 | ||||||
MIRT474213 | LCOR | ligand dependent nuclear receptor corepressor | ![]() |
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2 | 2 | ||||||
MIRT474335 | KMT2D | lysine methyltransferase 2D | ![]() |
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2 | 2 | ||||||
MIRT474871 | KDELR1 | KDEL endoplasmic reticulum protein retention receptor 1 | ![]() |
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2 | 2 | ||||||
MIRT477440 | ELOVL5 | ELOVL fatty acid elongase 5 | ![]() |
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2 | 2 | ||||||
MIRT478432 | DAZAP2 | DAZ associated protein 2 | ![]() |
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2 | 2 | ||||||
MIRT479851 | CCDC6 | coiled-coil domain containing 6 | ![]() |
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2 | 2 | ||||||
MIRT482507 | ACTB | actin beta | ![]() |
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2 | 2 | ||||||
MIRT485473 | IGF1R | insulin like growth factor 1 receptor | ![]() |
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2 | 8 | ||||||
MIRT485670 | CCDC64 | BICD family like cargo adaptor 1 | ![]() |
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2 | 4 | ||||||
MIRT485902 | PGPEP1 | pyroglutamyl-peptidase I | ![]() |
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2 | 4 | ||||||
MIRT488143 | PRRC2B | proline rich coiled-coil 2B | ![]() |
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2 | 4 | ||||||
MIRT489455 | MSC | musculin | ![]() |
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2 | 2 | ||||||
MIRT509568 | HIST2H2AB | histone cluster 2 H2A family member b | ![]() |
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2 | 4 | ||||||
MIRT513093 | DYNAP | dynactin associated protein | ![]() |
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2 | 2 | ||||||
MIRT513256 | CALM3 | calmodulin 3 | ![]() |
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2 | 2 | ||||||
MIRT514356 | UBBP4 | ubiquitin B pseudogene 4 | ![]() |
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2 | 6 | ||||||
MIRT522019 | PAQR3 | progestin and adipoQ receptor family member 3 | ![]() |
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2 | 4 | ||||||
MIRT523164 | HIST3H3 | histone cluster 3 H3 | ![]() |
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2 | 2 | ||||||
MIRT523297 | HIST1H1B | histone cluster 1 H1 family member b | ![]() |
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2 | 2 | ||||||
MIRT524782 | BAG5 | BCL2 associated athanogene 5 | ![]() |
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2 | 2 | ||||||
MIRT530921 | SCIN | scinderin | ![]() |
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2 | 2 | ||||||
MIRT533302 | USP44 | ubiquitin specific peptidase 44 | ![]() |
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2 | 2 | ||||||
MIRT552782 | YIPF4 | Yip1 domain family member 4 | ![]() |
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2 | 4 | ||||||
MIRT553981 | SRPR | SRP receptor alpha subunit | ![]() |
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2 | 2 | ||||||
MIRT563126 | ZNF215 | zinc finger protein 215 | ![]() |
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2 | 2 | ||||||
MIRT569025 | IL21R | interleukin 21 receptor | ![]() |
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2 | 2 | ||||||
MIRT573413 | RPL18A | ribosomal protein L18a | ![]() |
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2 | 2 | ||||||
MIRT574877 | Dnajc6 | DnaJ heat shock protein family (Hsp40) member C6 | ![]() |
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2 | 3 | ||||||
MIRT607538 | GLI2 | GLI family zinc finger 2 | ![]() |
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2 | 2 | ||||||
MIRT607682 | MAPK10 | mitogen-activated protein kinase 10 | ![]() |
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2 | 3 | ||||||
MIRT623791 | GK5 | glycerol kinase 5 (putative) | ![]() |
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2 | 2 | ||||||
MIRT628834 | FAM151B | family with sequence similarity 151 member B | ![]() |
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2 | 2 | ||||||
MIRT635547 | LEPREL1 | prolyl 3-hydroxylase 2 | ![]() |
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2 | 2 | ||||||
MIRT635698 | NMNAT2 | nicotinamide nucleotide adenylyltransferase 2 | ![]() |
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2 | 2 | ||||||
MIRT635906 | ARPC1B | actin related protein 2/3 complex subunit 1B | ![]() |
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2 | 2 | ||||||
MIRT649985 | MSI1 | musashi RNA binding protein 1 | ![]() |
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2 | 2 | ||||||
MIRT654900 | POMGNT1 | protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) | ![]() |
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2 | 2 | ||||||
MIRT655116 | PHF7 | PHD finger protein 7 | ![]() |
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2 | 2 | ||||||
MIRT658958 | DNAJC6 | DnaJ heat shock protein family (Hsp40) member C6 | ![]() |
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2 | 3 | ||||||
MIRT659665 | CDC42EP4 | CDC42 effector protein 4 | ![]() |
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2 | 2 | ||||||
MIRT668946 | CNBP | CCHC-type zinc finger nucleic acid binding protein | ![]() |
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2 | 2 | ||||||
MIRT691164 | APOL6 | apolipoprotein L6 | ![]() |
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2 | 2 | ||||||
MIRT692696 | MEAF6 | MYST/Esa1 associated factor 6 | ![]() |
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2 | 2 | ||||||
MIRT693245 | HBS1L | HBS1 like translational GTPase | ![]() |
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2 | 2 | ||||||
MIRT695203 | SCAMP3 | secretory carrier membrane protein 3 | ![]() |
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2 | 2 | ||||||
MIRT701957 | MINK1 | misshapen like kinase 1 | ![]() |
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2 | 2 | ||||||
MIRT706802 | APOL4 | apolipoprotein L4 | ![]() |
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2 | 2 | ||||||
MIRT716899 | CACNB2 | calcium voltage-gated channel auxiliary subunit beta 2 | ![]() |
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2 | 2 | ||||||
MIRT717632 | HLX | H2.0 like homeobox | ![]() |
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2 | 2 | ||||||
MIRT719052 | ZNF281 | zinc finger protein 281 | ![]() |
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2 | 2 | ||||||
MIRT722973 | GDE1 | glycerophosphodiester phosphodiesterase 1 | ![]() |
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2 | 2 | ||||||
MIRT723643 | RPTN | repetin | ![]() |
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2 | 2 | ||||||
MIRT734708 | NR3C2 | nuclear receptor subfamily 3 group C member 2 | ![]() |
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4 | 0 |
miRNA-Drug Associations | ||||||||||||||||||
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miRNA-Drug Resistance Associations | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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