miRTarBase - #MIRT525313


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pre-miRNA Information
pre-miRNA hsa-mir-3937   
Genomic Coordinates chrX: 39661216 - 39661321
Description Homo sapiens miR-3937 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-3937
Sequence 61| ACAGGCGGCUGUAGCAAUGGGGG |83
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1430604115 6 dbSNP
rs776622162 7 dbSNP
rs1283731816 11 dbSNP
rs1029784871 13 dbSNP
rs750525479 20 dbSNP
rs956488517 22 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol FANCA   
Synonyms FA, FA-H, FA1, FAA, FACA, FAH, FANCH
Description Fanconi anemia complementation group A
Transcript NM_000135   
Other Transcripts NM_001018112   
Expression
Putative miRNA Targets on FANCA
3'UTR of FANCA
(miRNA target sites are highlighted)		 
>FANCA|NM_000135|3'UTR
   1 CGGGACCTGCCACTGCACACCAGCCCAGCTCCCGTGTAAATAATTTATTACAAGCATAACATGGAGCTCTTGTTGCACTA
  81 AAAAGTGGATTACAAATCTCCTCGACTGCTTTAGTGGGGAAAGGAATCAATTATTTATGAACTGTCCGGCCCCGAGTCAC
 161 TCAGCGTTTGCGGGAAAATAAACCACTGGTCCCAGAGCAGAGGAAGGCTACTTGAGCCGGACACCAAGCCCGCCTCCAGC
 241 ACCAAGGGCGGGCAGCACCCTCCGACCCTCCCATGCGGGTGCACACGAAGGGTGAGGCTGACACAGCCACTGCGGAGTCC
 321 AGGCTGCTAGAGGTGCTCATCCTCACTGCCGTCCTCAGGTGGGTTCGGGCTTCACCGCCTGGCCCTCTGTGGTCACAGAG
 401 GGGCTCGGTGGCCCAGGTGGTGGTTCCGCCTCCAGGGGCAGGGCCTTGTCCTGGGTCTGTGTCAGCGGGTGCACCATGGA
 481 CATGTGTACATTGAGGTTGTGGGCCTTCTCAAACCGCCGGCCACACTGGTCACAGGCAAAGTCCAGCTCAGTCTCAGCCT
 561 TGTGTTTGGTCATGTGGTACTTGAGGGATGCCCGCTGCCTGCACTGGAACCCACAGACCTCACACCTGGGGGACAGAGGC
 641 AGATAAGAAGGTGCGAGGGCCACAGCCCTGGGAGGGGGTCCTGACTCACACTTACTGCAAAGGCTTGGCTCCCGAATGTC
 721 GCATTTGGTGGACGAGAAGGTGCTTCCGCTGCTTGAAGGTTTGTCCACATTCGTCACAGATATAGTTCCGCACCTCTGAG
 801 AGGGGAGAGTCCAGTGAGTCCAGGCCCCTGATGCTCCAACCTCCCGGGGGGACGACGATGACAATGTGAAACCATCACAG
 881 CTGGGAAGACATTTCTGCACATGGTTCACCATGCAGTGGGCCCAAGCAAGGGGCCTATGAGGGCCTCGTTTATTAAGATC
 961 TTTAAACTGCTTTATACACTGTCACGTGGCTTCATCAGCTGTGTGCATTTCAGGATGGTTTTTAAAGAAACCTCAGAAAG
1041 CTATTTCCTTAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' ggggguaaCGAUGUCGGCGGACa 5'
                  ||| || ||||||| 
Target 5' gggttcggGCTTCA-CCGCCTGg 3'
 361 - 382 154.00 -19.40
2 
miRNA  3' ggggguaACGAUGUCGGCGGACa 5'
                 |||  | ||:||||| 
Target 5' tgagggaTGC--CCGCTGCCTGc 3'
 582 - 602 136.00 -15.30
3 
miRNA  3' ggGGGU-AACGAUGUCGGCGGAca 5'
            ||||  || |:   ||||||  
Target 5' ggCCCAGGTGGTGGTTCCGCCTcc 3'
 410 - 433 133.00 -18.90
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
803289 1 ClinVar
974273 38 ClinVar
888507 42 ClinVar
888506 104 ClinVar
888505 109 ClinVar
888504 138 ClinVar
888503 144 ClinVar
321324 146 ClinVar
321323 154 ClinVar
321322 166 ClinVar
887249 172 ClinVar
974275 250 ClinVar
321321 252 ClinVar
321320 286 ClinVar
321319 287 ClinVar
321318 317 ClinVar
321317 385 ClinVar
321316 447 ClinVar
321315 521 ClinVar
886247 625 ClinVar
321314 654 ClinVar
886246 670 ClinVar
886245 672 ClinVar
321312 673 ClinVar
321313 673 ClinVar
321311 674 ClinVar
321310 679 ClinVar
321309 680 ClinVar
321308 819 ClinVar
321307 843 ClinVar
321306 851 ClinVar
321305 937 ClinVar
321304 986 ClinVar
321303 1011 ClinVar
321302 1012 ClinVar
COSN26975972 2 COSMIC
COSN31549687 9 COSMIC
COSN21012890 26 COSMIC
COSN4768142 132 COSMIC
COSN23881238 218 COSMIC
COSN32066519 354 COSMIC
COSM9370811 360 COSMIC
COSM9903638 362 COSMIC
COSM7216709 385 COSMIC
COSM384756 391 COSMIC
COSM4341515 391 COSMIC
COSM5605418 395 COSMIC
COSM1128838 402 COSMIC
COSM7637973 407 COSMIC
COSM6250303 412 COSMIC
COSM705288 426 COSMIC
COSM8629547 427 COSMIC
COSM435944 443 COSMIC
COSM6317440 444 COSMIC
COSM8916670 457 COSMIC
COSM5510858 458 COSMIC
COSM8082621 467 COSMIC
COSM6829007 473 COSMIC
COSM6505813 477 COSMIC
COSM9217152 508 COSMIC
COSM6587607 510 COSMIC
COSM1233801 515 COSMIC
COSM974931 516 COSMIC
COSM9138293 528 COSMIC
COSM472230 531 COSMIC
COSM3969767 534 COSMIC
COSM6224885 535 COSMIC
COSM7935888 593 COSMIC
COSM9082575 594 COSMIC
COSM974930 596 COSMIC
COSM298415 598 COSMIC
COSM8990762 619 COSMIC
COSM4933474 620 COSMIC
COSN26975982 654 COSMIC
COSN26975978 657 COSMIC
COSN20113210 670 COSMIC
COSN20113207 673 COSMIC
COSM4772042 692 COSMIC
COSM9030176 713 COSMIC
COSM460431 714 COSMIC
COSM4063648 721 COSMIC
COSM9040751 722 COSMIC
COSM7987592 731 COSMIC
COSM5740770 733 COSMIC
COSM6505811 739 COSMIC
COSM8401249 748 COSMIC
COSM5554209 757 COSMIC
COSM6828999 770 COSMIC
COSM3818742 779 COSMIC
COSM7483053 787 COSMIC
COSM9602369 789 COSMIC
COSM5792641 792 COSMIC
COSN26975981 817 COSMIC
COSN31601075 823 COSMIC
COSN30454221 828 COSMIC
COSN31491447 830 COSMIC
COSN30110358 845 COSMIC
COSN30492048 845 COSMIC
COSN26975975 846 COSMIC
COSN28885144 852 COSMIC
COSN30123864 857 COSMIC
COSN31500241 876 COSMIC
COSN30179628 882 COSMIC
COSN30517849 883 COSMIC
COSN30128031 901 COSMIC
COSN30493971 911 COSMIC
COSN31511058 912 COSMIC
COSN30133380 921 COSMIC
rs17227424 385 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs370357192 1 dbSNP
rs754732247 2 dbSNP
rs1164112884 3 dbSNP
rs751400000 4 dbSNP
rs1167675763 5 dbSNP
rs199675569 5 dbSNP
rs772589360 6 dbSNP
rs1458061374 7 dbSNP
rs1264601544 12 dbSNP
rs764735826 14 dbSNP
rs1267579056 15 dbSNP
rs761241462 20 dbSNP
rs776090306 23 dbSNP
rs776321328 24 dbSNP
rs1213542472 26 dbSNP
rs1439352623 27 dbSNP
rs1319253230 28 dbSNP
rs772736966 33 dbSNP
rs190645652 34 dbSNP
rs1293481487 35 dbSNP
rs1326248696 36 dbSNP
rs554525485 41 dbSNP
rs529748804 42 dbSNP
rs368670194 43 dbSNP
rs1325302475 44 dbSNP
rs922937790 48 dbSNP
rs145495509 50 dbSNP
rs1168504961 51 dbSNP
rs948918065 53 dbSNP
rs544435184 54 dbSNP
rs916052051 56 dbSNP
rs1285336718 66 dbSNP
rs1424046556 68 dbSNP
rs1163556456 69 dbSNP
rs1215123045 72 dbSNP
rs1415210877 72 dbSNP
rs964506692 74 dbSNP
rs1322939633 76 dbSNP
rs760732305 79 dbSNP
rs1390068432 84 dbSNP
rs1057480360 85 dbSNP
rs1287212835 88 dbSNP
rs1381351736 93 dbSNP
rs1229105590 97 dbSNP
rs1292978855 98 dbSNP
rs938807623 100 dbSNP
rs1005953047 101 dbSNP
rs536287114 103 dbSNP
rs55859244 104 dbSNP
rs746069040 104 dbSNP
rs1238708842 106 dbSNP
rs1026096277 107 dbSNP
rs55679217 109 dbSNP
rs1473348484 112 dbSNP
rs1282046834 113 dbSNP
rs147195004 115 dbSNP
rs968652405 118 dbSNP
rs1413096371 119 dbSNP
rs914493960 123 dbSNP
rs1361401535 124 dbSNP
rs1432402286 125 dbSNP
rs1340633481 129 dbSNP
rs573302337 131 dbSNP
rs1296972438 133 dbSNP
rs1312320780 134 dbSNP
rs1398088203 136 dbSNP
rs554999842 136 dbSNP
rs775549018 138 dbSNP
rs1030186205 139 dbSNP
rs1165302176 139 dbSNP
rs1057067682 140 dbSNP
rs186497529 142 dbSNP
rs575606938 144 dbSNP
rs1209574401 145 dbSNP
rs556325258 146 dbSNP
rs141761812 147 dbSNP
rs570739902 148 dbSNP
rs1191520249 149 dbSNP
rs1490999653 151 dbSNP
rs892010151 153 dbSNP
rs1230 154 dbSNP
rs887428503 154 dbSNP
rs533812797 155 dbSNP
rs1013197020 156 dbSNP
rs923490846 161 dbSNP
rs974454406 162 dbSNP
rs566175597 164 dbSNP
rs181842476 165 dbSNP
rs886052479 166 dbSNP
rs1276356562 171 dbSNP
rs577149121 172 dbSNP
rs568833102 173 dbSNP
rs984981073 174 dbSNP
rs950493395 183 dbSNP
rs1318104812 186 dbSNP
rs1277085353 189 dbSNP
rs1216251156 191 dbSNP
rs1369691740 196 dbSNP
rs1205246810 199 dbSNP
rs1271919646 200 dbSNP
rs1180146799 202 dbSNP
rs1248772014 206 dbSNP
rs1455097533 210 dbSNP
rs1193486928 217 dbSNP
rs551173588 218 dbSNP
rs903277788 219 dbSNP
rs1396088592 220 dbSNP
rs991918629 221 dbSNP
rs1435611566 224 dbSNP
rs190762834 231 dbSNP
rs1325300725 232 dbSNP
rs1347935011 233 dbSNP
rs1041759070 234 dbSNP
rs1440085594 239 dbSNP
rs1301245072 246 dbSNP
rs56049032 249 dbSNP
rs557319516 250 dbSNP
rs17233797 252 dbSNP
rs1337067720 253 dbSNP
rs1211207778 258 dbSNP
rs1292477431 260 dbSNP
rs905886601 263 dbSNP
rs1213448276 264 dbSNP
rs1481439086 267 dbSNP
rs1021626760 268 dbSNP
rs1372523018 269 dbSNP
rs931959948 269 dbSNP
rs1425905846 270 dbSNP
rs1165147392 272 dbSNP
rs923174934 274 dbSNP
rs975923448 275 dbSNP
rs1012078925 276 dbSNP
rs528787665 277 dbSNP
rs1014701946 278 dbSNP
rs1234979343 279 dbSNP
rs1199650989 282 dbSNP
rs17233804 286 dbSNP
rs17227417 287 dbSNP
rs1333681680 289 dbSNP
rs1233105366 293 dbSNP
rs1023324062 302 dbSNP
rs370868774 304 dbSNP
rs749463081 306 dbSNP
rs112177258 308 dbSNP
rs56346328 309 dbSNP
rs1378053079 310 dbSNP
rs756173179 311 dbSNP
rs748269284 313 dbSNP
rs200757877 314 dbSNP
rs908909494 316 dbSNP
rs201817705 317 dbSNP
rs1240540153 318 dbSNP
rs1194658503 319 dbSNP
rs1339122096 320 dbSNP
rs1256965469 324 dbSNP
rs751338766 326 dbSNP
rs1346026396 328 dbSNP
rs947496334 330 dbSNP
rs1413830497 331 dbSNP
rs374939326 334 dbSNP
rs199528837 335 dbSNP
rs148487227 338 dbSNP
rs1379299327 339 dbSNP
rs1326756829 340 dbSNP
rs1157171698 341 dbSNP
rs750033857 343 dbSNP
rs764817067 345 dbSNP
rs1174137642 346 dbSNP
rs1157992778 349 dbSNP
rs558326013 350 dbSNP
rs776319997 351 dbSNP
rs768125158 352 dbSNP
rs991969468 354 dbSNP
rs768448255 355 dbSNP
rs1378007772 358 dbSNP
rs1354465357 364 dbSNP
rs1180211362 366 dbSNP
rs200745032 367 dbSNP
rs1257247675 368 dbSNP
rs1202566985 369 dbSNP
rs775004716 370 dbSNP
rs771270307 373 dbSNP
rs763252585 375 dbSNP
rs56006529 376 dbSNP
rs55830337 377 dbSNP
rs765728284 378 dbSNP
rs1238197027 383 dbSNP
rs141300146 384 dbSNP
rs17227424 385 dbSNP
rs746878858 388 dbSNP
rs1031783942 390 dbSNP
rs779866663 391 dbSNP
rs750214492 392 dbSNP
rs370135143 395 dbSNP
rs1405074635 396 dbSNP
rs757018886 397 dbSNP
rs17227431 398 dbSNP
rs865830363 399 dbSNP
rs145686036 400 dbSNP
rs753395786 401 dbSNP
rs1257278189 402 dbSNP
rs763630525 403 dbSNP
rs1489412334 405 dbSNP
rs377737268 406 dbSNP
rs752058479 407 dbSNP
rs1357195517 408 dbSNP
rs1373593248 410 dbSNP
rs201151160 412 dbSNP
rs1231436012 414 dbSNP
rs1242438893 415 dbSNP
rs1306699555 417 dbSNP
rs761590956 418 dbSNP
rs763348972 419 dbSNP
rs773502564 422 dbSNP
rs1401413519 423 dbSNP
rs1343094704 426 dbSNP
rs769995042 427 dbSNP
rs762084649 428 dbSNP
rs1304259024 429 dbSNP
rs776839137 432 dbSNP
rs768660781 434 dbSNP
rs1460344346 435 dbSNP
rs747111210 437 dbSNP
rs1194875916 439 dbSNP
rs1476623906 443 dbSNP
rs1240548082 444 dbSNP
rs747571578 446 dbSNP
rs771942409 447 dbSNP
rs951863002 448 dbSNP
rs745653812 449 dbSNP
rs757122898 450 dbSNP
rs753485699 451 dbSNP
rs1220214389 457 dbSNP
rs1359653342 460 dbSNP
rs777592492 463 dbSNP
rs755648038 464 dbSNP
rs375543372 466 dbSNP
rs766890599 467 dbSNP
rs140576598 468 dbSNP
rs1323346918 469 dbSNP
rs750791038 471 dbSNP
rs1394367590 472 dbSNP
rs200903461 475 dbSNP
rs762176786 477 dbSNP
rs776783254 479 dbSNP
rs764329360 482 dbSNP
rs761025172 484 dbSNP
rs1386055678 486 dbSNP
rs760775797 488 dbSNP
rs1191847655 490 dbSNP
rs1163190624 496 dbSNP
rs888001596 497 dbSNP
rs1468130084 505 dbSNP
rs775480785 507 dbSNP
rs775820828 509 dbSNP
rs1049216505 510 dbSNP
rs1023770519 513 dbSNP
rs1305537102 514 dbSNP
rs780532307 515 dbSNP
rs745726629 516 dbSNP
rs960626938 518 dbSNP
rs568822228 519 dbSNP
rs144644592 521 dbSNP
rs1480288013 523 dbSNP
rs1377089391 524 dbSNP
rs749128867 526 dbSNP
rs777539105 528 dbSNP
rs747684842 529 dbSNP
rs1353051156 530 dbSNP
rs780637505 531 dbSNP
rs754517034 532 dbSNP
rs750834243 535 dbSNP
rs746256702 538 dbSNP
rs1467062083 541 dbSNP
rs939094866 541 dbSNP
rs1453866671 543 dbSNP
rs926453321 546 dbSNP
rs1189976388 547 dbSNP
rs757575773 552 dbSNP
rs142475962 559 dbSNP
rs764278170 568 dbSNP
rs1232044240 571 dbSNP
rs775785148 573 dbSNP
rs201383247 575 dbSNP
rs968384832 579 dbSNP
rs1486554928 593 dbSNP
rs767438860 594 dbSNP
rs759685733 595 dbSNP
rs774393332 598 dbSNP
rs772341815 605 dbSNP
rs749072880 608 dbSNP
rs773203161 616 dbSNP
rs769486874 619 dbSNP
rs779094661 625 dbSNP
rs747684200 629 dbSNP
rs1444437000 630 dbSNP
rs780907579 632 dbSNP
rs1311274808 634 dbSNP
rs1434350499 636 dbSNP
rs1381721615 638 dbSNP
rs745926138 638 dbSNP
rs754393489 639 dbSNP
rs1417457616 640 dbSNP
rs532231543 642 dbSNP
rs370763750 643 dbSNP
rs778989022 643 dbSNP
rs779360164 645 dbSNP
rs996212185 647 dbSNP
rs1255155795 648 dbSNP
rs1209630009 650 dbSNP
rs771351336 651 dbSNP
rs17227438 654 dbSNP
rs373907040 655 dbSNP
rs764509217 656 dbSNP
rs756514805 657 dbSNP
rs144483660 660 dbSNP
rs4399534 662 dbSNP
rs1166127274 663 dbSNP
rs752814489 665 dbSNP
rs767814198 666 dbSNP
rs1460346808 668 dbSNP
rs1357692542 669 dbSNP
rs17233812 670 dbSNP
rs749766786 670 dbSNP
rs751741235 671 dbSNP
rs17233819 672 dbSNP
rs62704561 673 dbSNP
rs66471129 673 dbSNP
rs1491554492 674 dbSNP
rs17233826 674 dbSNP
rs773291616 674 dbSNP
rs201727980 675 dbSNP
rs761686637 676 dbSNP
rs776104378 677 dbSNP
rs17233833 679 dbSNP
rs779679071 679 dbSNP
rs916349987 679 dbSNP
rs375657470 680 dbSNP
rs757962291 680 dbSNP
rs376007349 683 dbSNP
rs749738500 685 dbSNP
rs1179300910 686 dbSNP
rs1409407108 687 dbSNP
rs764764580 688 dbSNP
rs761678583 689 dbSNP
rs778367449 690 dbSNP
rs372441703 691 dbSNP
rs756394720 695 dbSNP
rs1007696829 696 dbSNP
rs753790953 697 dbSNP
rs368947676 698 dbSNP
rs1377295048 702 dbSNP
rs1184479963 703 dbSNP
rs543022451 704 dbSNP
rs755288718 705 dbSNP
rs751688287 713 dbSNP
rs1337613881 714 dbSNP
rs1049339038 716 dbSNP
rs766504577 720 dbSNP
rs763134179 721 dbSNP
rs750333922 723 dbSNP
rs374057605 725 dbSNP
rs1423350127 727 dbSNP
rs1372549908 731 dbSNP
rs776536953 733 dbSNP
rs369592437 734 dbSNP
rs1294231215 736 dbSNP
rs760386026 737 dbSNP
rs1277811616 738 dbSNP
rs775127852 739 dbSNP
rs1164171987 740 dbSNP
rs771522551 741 dbSNP
rs1374639999 745 dbSNP
rs745414313 747 dbSNP
rs149209309 748 dbSNP
rs1267381282 752 dbSNP
rs530844175 758 dbSNP
rs770383333 771 dbSNP
rs781666183 772 dbSNP
rs138414698 773 dbSNP
rs1373902139 775 dbSNP
rs751769855 781 dbSNP
rs780450614 782 dbSNP
rs897527939 783 dbSNP
rs758515413 788 dbSNP
rs750573426 789 dbSNP
rs765066482 790 dbSNP
rs757278617 791 dbSNP
rs753571435 792 dbSNP
rs1416693417 793 dbSNP
rs763883655 797 dbSNP
rs755674705 798 dbSNP
rs1398276954 799 dbSNP
rs764019155 803 dbSNP
rs996695376 803 dbSNP
rs199778951 805 dbSNP
rs775082904 806 dbSNP
rs760540231 807 dbSNP
rs939114184 807 dbSNP
rs767196100 811 dbSNP
rs926366512 814 dbSNP
rs759022680 817 dbSNP
rs1245964982 818 dbSNP
rs186050933 819 dbSNP
rs200396402 820 dbSNP
rs1438934521 821 dbSNP
rs369086041 824 dbSNP
rs777013443 825 dbSNP
rs769097470 826 dbSNP
rs915046341 827 dbSNP
rs1281297736 828 dbSNP
rs1213358248 830 dbSNP
rs747413104 834 dbSNP
rs377568154 836 dbSNP
rs780395605 837 dbSNP
rs758745191 838 dbSNP
rs564745463 839 dbSNP
rs779117643 840 dbSNP
rs757289385 841 dbSNP
rs1390601079 842 dbSNP
rs201316239 843 dbSNP
rs764049034 845 dbSNP
rs371468362 846 dbSNP
rs1476514584 849 dbSNP
rs886052478 851 dbSNP
rs1419053872 852 dbSNP
rs976046168 853 dbSNP
rs966539728 854 dbSNP
rs759493074 856 dbSNP
rs916427497 857 dbSNP
rs1054946709 858 dbSNP
rs751394130 859 dbSNP
rs1327609120 863 dbSNP
rs766049160 864 dbSNP
rs1269280347 866 dbSNP
rs952273424 868 dbSNP
rs1028227841 876 dbSNP
rs1217216929 877 dbSNP
rs977738534 878 dbSNP
rs1336123849 895 dbSNP
rs1213538891 897 dbSNP
rs1488698920 903 dbSNP
rs1264597634 904 dbSNP
rs1448869641 905 dbSNP
rs1242887366 906 dbSNP
rs1241789947 911 dbSNP
rs878961904 913 dbSNP
rs993748964 914 dbSNP
rs898049506 916 dbSNP
rs762137538 922 dbSNP
rs1034662653 934 dbSNP
rs990780550 935 dbSNP
rs55794507 937 dbSNP
rs1337991641 938 dbSNP
rs1029599914 947 dbSNP
rs554604608 948 dbSNP
rs1339141649 950 dbSNP
rs1233038372 951 dbSNP
rs1264247617 952 dbSNP
rs1353435199 959 dbSNP
rs1205830311 960 dbSNP
rs1283593654 962 dbSNP
rs1326078503 970 dbSNP
rs1190249218 973 dbSNP
rs181463391 977 dbSNP
rs575197863 978 dbSNP
rs946451720 979 dbSNP
rs556907805 980 dbSNP
rs1470442371 981 dbSNP
rs1157496317 983 dbSNP
rs1436034157 985 dbSNP
rs16966023 986 dbSNP
rs1395854762 989 dbSNP
rs1001002219 998 dbSNP
rs1310982024 998 dbSNP
rs1240320316 999 dbSNP
rs1052228819 1003 dbSNP
rs1292094241 1005 dbSNP
rs1459601600 1008 dbSNP
rs935242999 1010 dbSNP
rs17227452 1011 dbSNP
rs886052477 1012 dbSNP
rs976098717 1014 dbSNP
rs944748172 1027 dbSNP
rs547236392 1030 dbSNP
rs910527808 1041 dbSNP
rs986264914 1044 dbSNP
rs1370793775 1053 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545214. RNA binding protein: AGO3. Condition:Control ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' ggggguaacGAUGUCGGCGGACa 5'
                   || || ||||||| 
Target 5' ---------CUUCA-CCGCCUGg 3'
 		1 - 13
Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions hESCs (WA-09)
Disease 2175.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in SRR359787. RNA binding protein: AGO2. Condition:4-thiouridine ...

- Lipchina I; Elkabetz Y; Hafner M; Sheridan et al., 2011, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' ggggguaaCGAUGUCGGCGGACa 5'
                  ||| || ||||||| 
Target 5' ggguucggGCUUCA-CCGCCUGg 3'
 		8 - 29
Article - Lipchina I; Elkabetz Y; Hafner M; Sheridan et al.
- Genes & development, 2011
MicroRNAs are important regulators in many cellular processes, including stem cell self-renewal. Recent studies demonstrated their function as pluripotency factors with the capacity for somatic cell reprogramming. However, their role in human embryonic stem (ES) cells (hESCs) remains poorly understood, partially due to the lack of genome-wide strategies to identify their targets. Here, we performed comprehensive microRNA profiling in hESCs and in purified neural and mesenchymal derivatives. Using a combination of AGO cross-linking and microRNA perturbation experiments, together with computational prediction, we identified the targets of the miR-302/367 cluster, the most abundant microRNAs in hESCs. Functional studies identified novel roles of miR-302/367 in maintaining pluripotency and regulating hESC differentiation. We show that in addition to its role in TGF-beta signaling, miR-302/367 promotes bone morphogenetic protein (BMP) signaling by targeting BMP inhibitors TOB2, DAZAP2, and SLAIN1. This study broadens our understanding of microRNA function in hESCs and is a valuable resource for future studies in this area.
LinkOut: [PMID: 22012620]
CLIP-seq Support 1 for dataset GSM545214
Method / RBP PAR-CLIP / AGO3
Cell line / Condition HEK293 / Control
Location of target site ENST00000568369.1 | 3UTR | cuucaccgccuggcccuc
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset SRR359787
Method / RBP PAR-CLIP / AGO2
Cell line / Condition hESCs (WA-09) / 4-thiouridine, RNase T1
Location of target site ENST00000568369.1 | 3UTR | Cucagguggguucgggcuucaccgccuggcccucug
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22012620 / SRX103431
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
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40 hsa-miR-3937 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT332487 CD81 CD81 molecule 2 2
MIRT441327 NDUFA11 NADH:ubiquinone oxidoreductase subunit A11 2 4
MIRT454032 EIF3CL eukaryotic translation initiation factor 3 subunit C like 2 2
MIRT458086 EIF3C eukaryotic translation initiation factor 3 subunit C 2 2
MIRT460785 VPS37B VPS37B, ESCRT-I subunit 2 2
MIRT463150 ZNF385A zinc finger protein 385A 2 4
MIRT467162 SREBF2 sterol regulatory element binding transcription factor 2 2 2
MIRT469618 RAI1 retinoic acid induced 1 2 4
MIRT472258 NFIC nuclear factor I C 2 2
MIRT487587 FAM83H family with sequence similarity 83 member H 2 4
MIRT489302 B4GALNT4 beta-1,4-N-acetyl-galactosaminyltransferase 4 2 4
MIRT489741 GNAI2 G protein subunit alpha i2 2 4
MIRT490038 PCSK4 proprotein convertase subtilisin/kexin type 4 2 2
MIRT490767 SRCIN1 SRC kinase signaling inhibitor 1 2 2
MIRT491750 SEMA3F semaphorin 3F 2 2
MIRT492690 PHYHIP phytanoyl-CoA 2-hydroxylase interacting protein 2 2
MIRT504843 RRP36 ribosomal RNA processing 36 2 4
MIRT510116 IRAK3 interleukin 1 receptor associated kinase 3 2 8
MIRT525313 FANCA Fanconi anemia complementation group A 2 4
MIRT569801 IGDCC3 immunoglobulin superfamily DCC subclass member 3 2 2
MIRT570224 SLC27A1 solute carrier family 27 member 1 2 2
MIRT629378 FAHD1 fumarylacetoacetate hydrolase domain containing 1 2 2
MIRT633104 CBX5 chromobox 5 2 2
MIRT645036 ATAD3C ATPase family, AAA domain containing 3C 2 2
MIRT660973 ABI2 abl interactor 2 2 2
MIRT671225 CLSTN1 calsyntenin 1 2 2
MIRT672046 SMTNL2 smoothelin like 2 2 2
MIRT677314 CPSF2 cleavage and polyadenylation specific factor 2 2 2
MIRT678290 PTRH2 peptidyl-tRNA hydrolase 2 2 2
MIRT693477 ZNF707 zinc finger protein 707 2 2
MIRT693576 PIGR polymeric immunoglobulin receptor 2 2
MIRT696832 PLLP plasmolipin 2 2
MIRT700149 RNF115 ring finger protein 115 2 2
MIRT703760 FAM118A family with sequence similarity 118 member A 2 2
MIRT705798 ALDH6A1 aldehyde dehydrogenase 6 family member A1 2 2
MIRT709105 SEPT4 septin 4 2 2
MIRT710235 ARMCX6 armadillo repeat containing, X-linked 6 2 2
MIRT711422 EPHA4 EPH receptor A4 2 2
MIRT712529 CYTH2 cytohesin 2 2 2
MIRT714081 ZNF532 zinc finger protein 532 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-3937 Fluorouracil 3385 NSC19893 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-miR-3937 Gemcitabine 60750 NSC613327 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-miR-3937 Platinum 23939 sensitive High Ovarian Cancer tissue
hsa-miR-3937 Dabrafenib 44462760 NSC764134 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-3937 Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-3937 Paclitaxel 36314 NSC125973 approved resistant High Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-3937 Fulvestrant 17756771 NSC719276 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-3937 Tamoxifen 2733525 NSC180973 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-3937 Gemcitabine 60750 NSC613327 approved sensitive High Pancreatic Cancer cell line (AsPC-1)
hsa-miR-3937 Taxane/Cisplatin/Fluorouracil sensitive High Hypopharyngeal Squamous Cell Carcinoma tissue
hsa-miR-3937 Paclitaxel 36314 NSC125973 approved resistant High Ovarian Cancer cell line (A2780)
hsa-mir-3937 Dabrafenib 44462760 NSC764134 approved resistant cell line (A375)
hsa-mir-3937 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-miR-3937 Temozolomide 5394 NSC362856 approved sensitive cell line (U251)
hsa-miR-3937 Cisplatin 5460033 NSC119875 approved sensitive cell line
hsa-miR-3937 Doxorubicin 31703 NSC123127 approved resistant cell line (HS578T)
hsa-miR-3937 Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-3937 Paclitaxel 36314 NSC125973 approved resistant cell line (A2780)
hsa-miR-3937 Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-miR-3937 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-3937 Neoadjuvant chemotherapy sensitive tissue (breast cancer)
hsa-miR-3937 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-miR-3937 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)
hsa-miR-3937 Docetaxel+Cisplatin+5-Fluorouracil resistant tissue (hypopharyngeal squamous cell carcinoma)
hsa-miR-3937 Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide resistant cell line (Bads-200)

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