ID	Duplex structure	Position	Score	MFE
1	miRNA 3' gaaGACCGAGGUUCAGGUCa 5' ||||:|::| ||||| Target 5' acaCTGGTTTTACCTCCAGg 3'	3 - 22	109.00	-17.20
2	miRNA 3' gaagaccgAGGUUCAGGUca 5' ||||| |||| Target 5' aaaaataaTCCAAATCCAtc 3'	30 - 49	108.00	-8.40
3	miRNA 3' gaaGACCGAGGUUCAGGUca 5' || |: :|||| |:| Target 5' acaCTTGTCTCAAGCCTAtc 3'	208 - 227	93.00	-8.20

Mutant ID	Mutant Position	Mutant Source
COSN30471695	42	COSMIC
COSN17132576	66	COSMIC
COSN30178506	79	COSMIC
COSN30134834	112	COSMIC
COSN31554823	113	COSMIC
COSN30509412	114	COSMIC
COSN30175071	183	COSMIC
COSN31559050	187	COSMIC
COSN16707020	215	COSMIC
COSN16176427	266	COSMIC
COSN24414294	666	COSMIC
COSN23378959	835	COSMIC
COSN16506040	974	COSMIC
COSN27642003	1252	COSMIC
COSN19062922	1422	COSMIC
COSN29077752	1499	COSMIC
COSN18827149	1586	COSMIC
COSN15020319	1795	COSMIC
COSN28201851	2330	COSMIC
COSN5898091	2330	COSMIC
COSN20807214	2471	COSMIC
COSN16663374	2500	COSMIC
COSN1517662	2855	COSMIC
rs143429471	2859	GWAS

Mutant ID	Mutant Position	Mutant Source
rs758658063	6	dbSNP
rs1409956676	7	dbSNP
rs1299514038	10	dbSNP
rs780425513	11	dbSNP
rs866434562	13	dbSNP
rs1213458121	17	dbSNP
rs1386500048	21	dbSNP
rs61910597	22	dbSNP
rs375034133	26	dbSNP
rs1400230257	28	dbSNP
rs375649116	30	dbSNP
rs1236604376	37	dbSNP
rs781764718	41	dbSNP
rs1009572057	43	dbSNP
rs1365356859	48	dbSNP
rs1274608867	50	dbSNP
rs532763305	54	dbSNP
rs111712166	61	dbSNP
rs1437131269	68	dbSNP
rs903987334	74	dbSNP
rs1001433754	78	dbSNP
rs1033881592	86	dbSNP
rs1409436564	95	dbSNP
rs1417469805	110	dbSNP
rs1471398727	113	dbSNP
rs571193646	114	dbSNP
rs1478284230	121	dbSNP
rs1407590562	124	dbSNP
rs1489371292	125	dbSNP
rs992443821	125	dbSNP
rs984731205	137	dbSNP
rs532019294	138	dbSNP
rs1024619912	157	dbSNP
rs1305186124	162	dbSNP
rs1259440949	163	dbSNP
rs910493405	179	dbSNP
rs961041910	182	dbSNP
rs972431468	187	dbSNP
rs755171540	190	dbSNP
rs919665722	201	dbSNP
rs931105018	210	dbSNP
rs1385431568	216	dbSNP
rs985677280	230	dbSNP
rs1294565356	233	dbSNP
rs776357469	244	dbSNP
rs911076488	253	dbSNP
rs943923653	256	dbSNP
rs1172947736	257	dbSNP
rs781366653	261	dbSNP
rs550442374	263	dbSNP
rs1052910050	265	dbSNP
rs568658779	271	dbSNP
rs75499917	273	dbSNP
rs748386361	283	dbSNP
rs770017510	284	dbSNP
rs553931591	286	dbSNP
rs1479627695	290	dbSNP
rs566090699	296	dbSNP
rs1221747453	303	dbSNP
rs945377734	309	dbSNP
rs1460525621	313	dbSNP
rs1260849897	315	dbSNP
rs1042404037	320	dbSNP
rs1314252949	321	dbSNP
rs1348050156	327	dbSNP
rs1210792605	333	dbSNP
rs879798231	339	dbSNP
rs1223678709	344	dbSNP
rs1278862077	344	dbSNP
rs879573429	349	dbSNP
rs1439895151	350	dbSNP
rs1182918817	361	dbSNP
rs539417114	365	dbSNP
rs867220946	368	dbSNP
rs190735333	372	dbSNP
rs1014222592	381	dbSNP
rs951818809	385	dbSNP
rs778023512	386	dbSNP
rs575959972	393	dbSNP
rs1025227144	398	dbSNP
rs1158139633	410	dbSNP
rs1417120249	411	dbSNP
rs961655844	412	dbSNP
rs1453934894	419	dbSNP
rs1382071634	421	dbSNP
rs1179240462	430	dbSNP
rs1172906645	432	dbSNP
rs1240741850	436	dbSNP
rs993817888	439	dbSNP
rs749711869	447	dbSNP
rs1483391370	459	dbSNP
rs1259826121	463	dbSNP
rs1215494443	464	dbSNP
rs1017430809	475	dbSNP
rs1312094513	477	dbSNP
rs1329254052	479	dbSNP
rs771194096	480	dbSNP
rs1382048716	498	dbSNP
rs952545782	505	dbSNP
rs1403139312	509	dbSNP
rs1288560972	513	dbSNP
rs1417619213	517	dbSNP
rs1353712352	520	dbSNP
rs1159107473	523	dbSNP
rs117266941	524	dbSNP
rs1366163446	525	dbSNP
rs911010530	527	dbSNP
rs555151258	530	dbSNP
rs573453942	531	dbSNP
rs965244037	532	dbSNP
rs1232987412	533	dbSNP
rs976595104	544	dbSNP
rs913143829	550	dbSNP
rs1217923863	554	dbSNP
rs141826276	555	dbSNP
rs1042351737	569	dbSNP
rs1264241251	574	dbSNP
rs925307353	576	dbSNP
rs936724977	577	dbSNP
rs1055224952	578	dbSNP
rs1436494324	601	dbSNP
rs1215787021	605	dbSNP
rs776317415	610	dbSNP
rs559149474	611	dbSNP
rs1013743913	614	dbSNP
rs1046627964	616	dbSNP
rs1476314115	617	dbSNP
rs1164995789	625	dbSNP
rs1457968770	627	dbSNP
rs897391260	638	dbSNP
rs1372009828	639	dbSNP
rs994437996	640	dbSNP
rs1478609163	641	dbSNP
rs1265740401	642	dbSNP
rs1026621635	643	dbSNP
rs952420092	649	dbSNP
rs1490301922	652	dbSNP
rs938282833	653	dbSNP
rs1418523070	655	dbSNP
rs1212219444	660	dbSNP
rs1463904451	672	dbSNP
rs1007011171	677	dbSNP
rs761776414	677	dbSNP
rs896161221	677	dbSNP
rs547119041	682	dbSNP
rs1404096820	684	dbSNP
rs965537566	688	dbSNP
rs1325371069	695	dbSNP
rs1387297944	696	dbSNP
rs1395087360	700	dbSNP
rs976541316	711	dbSNP
rs1394703620	713	dbSNP
rs1005956306	726	dbSNP
rs533027371	733	dbSNP
rs1320935751	734	dbSNP
rs1423864935	744	dbSNP
rs1327692031	745	dbSNP
rs1017461892	748	dbSNP
rs1201571804	759	dbSNP
rs1452726290	763	dbSNP
rs1270199871	768	dbSNP
rs964502224	770	dbSNP
rs913091382	777	dbSNP
rs967246244	781	dbSNP
rs577229054	786	dbSNP
rs1258948786	803	dbSNP
rs978663972	806	dbSNP
rs760340728	811	dbSNP
rs997443473	814	dbSNP
rs1274225647	827	dbSNP
rs1233828441	833	dbSNP
rs1468173371	834	dbSNP
rs1329282774	846	dbSNP
rs544397791	850	dbSNP
rs563268540	858	dbSNP
rs1280545351	876	dbSNP
rs925242941	878	dbSNP
rs112448335	881	dbSNP
rs1400476260	882	dbSNP
rs1412413136	885	dbSNP
rs991261252	885	dbSNP
rs1325924858	894	dbSNP
rs1423440683	898	dbSNP
rs916655665	899	dbSNP
rs1478589715	901	dbSNP
rs1380214642	904	dbSNP
rs532082469	906	dbSNP
rs1441553398	912	dbSNP
rs550458247	914	dbSNP
rs1193769640	916	dbSNP
rs1241494261	931	dbSNP
rs913892664	933	dbSNP
rs1476812644	935	dbSNP
rs1352785922	940	dbSNP
rs1046575903	941	dbSNP
rs10219270	945	dbSNP
rs765133936	948	dbSNP
rs529439625	953	dbSNP
rs1460537484	956	dbSNP
rs1313765953	958	dbSNP
rs547888445	963	dbSNP
rs61676288	963	dbSNP
rs1415401168	965	dbSNP
rs888734522	965	dbSNP
rs1006551311	967	dbSNP
rs1386493025	973	dbSNP
rs1422088564	975	dbSNP
rs1380957192	981	dbSNP
rs1181318443	989	dbSNP
rs1382342844	994	dbSNP
rs1018387471	1002	dbSNP
rs1188587630	1007	dbSNP
rs1487800535	1007	dbSNP
rs1283636975	1008	dbSNP
rs757968380	1023	dbSNP
rs900902312	1024	dbSNP
rs559386843	1028	dbSNP
rs1354363164	1043	dbSNP
rs1318225503	1044	dbSNP
rs1289122469	1046	dbSNP
rs10219424	1047	dbSNP
rs918206230	1048	dbSNP
rs539900273	1051	dbSNP
rs557778029	1052	dbSNP
rs1361704277	1053	dbSNP
rs1164759413	1055	dbSNP
rs1403670160	1073	dbSNP
rs887420568	1075	dbSNP
rs1163991439	1078	dbSNP
rs1477630033	1079	dbSNP
rs978611448	1084	dbSNP
rs551509967	1097	dbSNP
rs1488528326	1102	dbSNP
rs569707580	1104	dbSNP
rs958899779	1105	dbSNP
rs761737457	1106	dbSNP
rs569731109	1107	dbSNP
rs1322942178	1116	dbSNP
rs1290001424	1121	dbSNP
rs537661748	1140	dbSNP
rs1315655359	1143	dbSNP
rs997389689	1144	dbSNP
rs562677814	1148	dbSNP
rs750403379	1155	dbSNP
rs1030152712	1159	dbSNP
rs1402223635	1161	dbSNP
rs1204578939	1166	dbSNP
rs949418172	1176	dbSNP
rs1284010165	1187	dbSNP
rs982200663	1195	dbSNP
rs1351639480	1197	dbSNP
rs536949237	1199	dbSNP
rs1421739028	1207	dbSNP
rs1010127238	1209	dbSNP
rs930124299	1212	dbSNP
rs758344977	1214	dbSNP
rs1021394326	1216	dbSNP
rs1189351809	1219	dbSNP
rs1489443086	1224	dbSNP
rs1247263185	1235	dbSNP
rs1049073300	1246	dbSNP
rs1197440127	1258	dbSNP
rs1474794288	1259	dbSNP
rs968035218	1261	dbSNP
rs1218865522	1270	dbSNP
rs1308387682	1275	dbSNP
rs1184925950	1293	dbSNP
rs1301041267	1294	dbSNP
rs1217935514	1305	dbSNP
rs1370321492	1307	dbSNP
rs1365236290	1311	dbSNP
rs979492871	1314	dbSNP
rs1033756654	1325	dbSNP
rs1333547958	1328	dbSNP
rs888693046	1330	dbSNP
rs942969244	1331	dbSNP
rs1437065432	1332	dbSNP
rs1039347730	1336	dbSNP
rs900862278	1343	dbSNP
rs1355220907	1348	dbSNP
rs1173661923	1349	dbSNP
rs781452584	1367	dbSNP
rs1425762933	1381	dbSNP
rs1394703514	1387	dbSNP
rs929559348	1390	dbSNP
rs1309630214	1401	dbSNP
rs1239478447	1402	dbSNP
rs983697004	1412	dbSNP
rs184176744	1417	dbSNP
rs1253920775	1420	dbSNP
rs1208431859	1423	dbSNP
rs1314377813	1427	dbSNP
rs1304722305	1436	dbSNP
rs1238606080	1440	dbSNP
rs1283897677	1447	dbSNP
rs371681273	1449	dbSNP
rs1019995763	1450	dbSNP
rs573794761	1451	dbSNP
rs752777206	1453	dbSNP
rs1378697503	1472	dbSNP
rs1301378790	1475	dbSNP
rs1033280648	1476	dbSNP
rs1467382130	1479	dbSNP
rs1212925143	1483	dbSNP
rs958623539	1487	dbSNP
rs1417808324	1494	dbSNP
rs991826548	1495	dbSNP
rs1178680843	1496	dbSNP
rs1422779237	1520	dbSNP
rs1051613408	1525	dbSNP
rs1183244468	1527	dbSNP
rs1484409394	1531	dbSNP
rs1482794973	1534	dbSNP
rs1281523977	1535	dbSNP
rs147121213	1547	dbSNP
rs567897263	1548	dbSNP
rs1288849113	1549	dbSNP
rs749455733	1559	dbSNP
rs553108253	1564	dbSNP
rs147715632	1568	dbSNP
rs1321262497	1575	dbSNP
rs918665716	1584	dbSNP
rs1310759537	1586	dbSNP
rs904429456	1589	dbSNP
rs372420965	1592	dbSNP
rs1297386951	1603	dbSNP
rs1397955160	1606	dbSNP
rs1033620638	1609	dbSNP
rs984289074	1620	dbSNP
rs1366218955	1627	dbSNP
rs910059785	1634	dbSNP
rs1025581730	1643	dbSNP
rs1174788754	1644	dbSNP
rs1193362274	1645	dbSNP
rs553346423	1649	dbSNP
rs577626903	1653	dbSNP
rs1265962984	1654	dbSNP
rs1206249262	1658	dbSNP
rs1465010144	1663	dbSNP
rs145868277	1664	dbSNP
rs544151704	1669	dbSNP
rs1397670128	1675	dbSNP
rs909506918	1677	dbSNP
rs1391023750	1683	dbSNP
rs562337544	1688	dbSNP
rs1373244021	1693	dbSNP
rs529576245	1707	dbSNP
rs1235186104	1714	dbSNP
rs547703352	1715	dbSNP
rs1302801983	1719	dbSNP
rs368169895	1720	dbSNP
rs974435854	1733	dbSNP
rs1386162161	1737	dbSNP
rs775671484	1737	dbSNP
rs1294740928	1741	dbSNP
rs1230986282	1749	dbSNP
rs1422451006	1752	dbSNP
rs1168172203	1753	dbSNP
rs921571435	1754	dbSNP
rs1252794178	1756	dbSNP
rs1480870656	1757	dbSNP
rs1194461744	1761	dbSNP
rs1451571448	1762	dbSNP
rs188685618	1773	dbSNP
rs1041401196	1780	dbSNP
rs1197621694	1790	dbSNP
rs1236023759	1792	dbSNP
rs933077595	1801	dbSNP
rs1469010383	1804	dbSNP
rs533306332	1805	dbSNP
rs1196999087	1809	dbSNP
rs1319676752	1813	dbSNP
rs1270581962	1825	dbSNP
rs1051487392	1830	dbSNP
rs563826458	1832	dbSNP
rs902921149	1849	dbSNP
rs7938692	1850	dbSNP
rs1431883028	1860	dbSNP
rs1398920263	1863	dbSNP
rs1054264696	1866	dbSNP
rs1466886358	1867	dbSNP
rs1399037432	1871	dbSNP
rs775951942	1877	dbSNP
rs569736225	1878	dbSNP
rs529828276	1880	dbSNP
rs374945836	1882	dbSNP
rs1388675678	1888	dbSNP
rs904471204	1896	dbSNP
rs368048272	1901	dbSNP
rs1439743603	1906	dbSNP
rs1274036370	1909	dbSNP
rs971337298	1926	dbSNP
rs1396905613	1927	dbSNP
rs1441960502	1928	dbSNP
rs1033653438	1930	dbSNP
rs1375459817	1932	dbSNP
rs1325231294	1938	dbSNP
rs1448407544	1939	dbSNP
rs1335961583	1948	dbSNP
rs895126928	1952	dbSNP
rs1414258062	1953	dbSNP
rs1365600618	1954	dbSNP
rs1217395660	1956	dbSNP
rs1176023783	1957	dbSNP
rs1435918205	1957	dbSNP
rs34955804	1957	dbSNP
rs796125220	1957	dbSNP
rs1013626713	1960	dbSNP
rs1471231462	1969	dbSNP
rs1233659007	1972	dbSNP
rs534911830	1974	dbSNP
rs1440419071	1993	dbSNP
rs1259388903	1998	dbSNP
rs1211462269	2001	dbSNP
rs372313269	2003	dbSNP
rs950859366	2004	dbSNP
rs1224955222	2007	dbSNP
rs1350847210	2010	dbSNP
rs1283172536	2013	dbSNP
rs1445375676	2017	dbSNP
rs577723961	2018	dbSNP
rs1003532076	2022	dbSNP
rs749376549	2023	dbSNP
rs111754565	2035	dbSNP
rs1321444907	2035	dbSNP
rs1491434124	2035	dbSNP
rs199747306	2035	dbSNP
rs397955976	2035	dbSNP
rs60962125	2035	dbSNP
rs774097826	2035	dbSNP
rs1336407767	2036	dbSNP
rs1213942107	2037	dbSNP
rs1487874182	2045	dbSNP
rs1016832274	2047	dbSNP
rs768050329	2055	dbSNP
rs548440228	2057	dbSNP
rs1245608850	2066	dbSNP
rs921602365	2074	dbSNP
rs910019686	2075	dbSNP
rs678485	2077	dbSNP
rs1340300957	2082	dbSNP
rs1296821542	2094	dbSNP
rs987533224	2097	dbSNP
rs975649822	2099	dbSNP
rs922852039	2100	dbSNP
rs934265741	2104	dbSNP
rs1263101237	2115	dbSNP
rs913018341	2117	dbSNP
rs751814676	2118	dbSNP
rs945767082	2121	dbSNP
rs1166013280	2124	dbSNP
rs1041338707	2128	dbSNP
rs1421227395	2129	dbSNP
rs924292123	2132	dbSNP
rs935728267	2133	dbSNP
rs1054614790	2151	dbSNP
rs1246103385	2159	dbSNP
rs1218724825	2163	dbSNP
rs1469470565	2166	dbSNP
rs894263402	2172	dbSNP
rs1197637014	2173	dbSNP
rs575329872	2175	dbSNP
rs925759003	2179	dbSNP
rs1293922379	2182	dbSNP
rs1348200368	2184	dbSNP
rs1216734541	2185	dbSNP
rs1363248280	2204	dbSNP
rs1274839568	2205	dbSNP
rs369862968	2209	dbSNP
rs1438799550	2210	dbSNP
rs1396795472	2215	dbSNP
rs1276366288	2218	dbSNP
rs1326761428	2225	dbSNP
rs1465323432	2227	dbSNP
rs1398424846	2233	dbSNP
rs1433031669	2244	dbSNP
rs1013156927	2246	dbSNP
rs1172242559	2258	dbSNP
rs937276380	2260	dbSNP
rs867860116	2261	dbSNP
rs1189401386	2269	dbSNP
rs895157973	2270	dbSNP
rs1013627954	2273	dbSNP
rs1399325269	2275	dbSNP
rs1456151703	2278	dbSNP
rs1046811209	2293	dbSNP
rs1276004983	2299	dbSNP
rs1207051294	2306	dbSNP
rs138417866	2308	dbSNP
rs993432460	2324	dbSNP
rs761318904	2328	dbSNP
rs1016452351	2331	dbSNP
rs1373225595	2332	dbSNP
rs963500759	2348	dbSNP
rs996440715	2350	dbSNP
rs1371439302	2352	dbSNP
rs1300182898	2364	dbSNP
rs1176220935	2367	dbSNP
rs560918313	2368	dbSNP
rs765089517	2376	dbSNP
rs954936632	2379	dbSNP
rs679810	2383	dbSNP
rs1157509253	2385	dbSNP
rs1488214397	2392	dbSNP
rs1192148867	2393	dbSNP
rs1017433398	2398	dbSNP
rs1177430306	2399	dbSNP
rs1481132467	2407	dbSNP
rs964197239	2414	dbSNP
rs763007321	2418	dbSNP
rs541702413	2419	dbSNP
rs559707602	2427	dbSNP
rs533540612	2433	dbSNP
rs551473918	2434	dbSNP
rs1029801580	2436	dbSNP
rs967166391	2438	dbSNP
rs1281739107	2450	dbSNP
rs978893442	2457	dbSNP
rs955590513	2458	dbSNP
rs767853558	2459	dbSNP
rs1411960042	2460	dbSNP
rs1378117083	2470	dbSNP
rs925791239	2478	dbSNP
rs1159835744	2484	dbSNP
rs377299265	2488	dbSNP
rs563475074	2494	dbSNP
rs866772717	2497	dbSNP
rs977650216	2499	dbSNP
rs1055550638	2502	dbSNP
rs1297578764	2502	dbSNP
rs1214533448	2507	dbSNP
rs924238322	2511	dbSNP
rs865777527	2514	dbSNP
rs1159320404	2515	dbSNP
rs935662029	2518	dbSNP
rs1422912521	2521	dbSNP
rs1377013291	2526	dbSNP
rs1186238613	2531	dbSNP
rs1486896626	2533	dbSNP
rs917189300	2534	dbSNP
rs1216536582	2538	dbSNP
rs766475939	2546	dbSNP
rs949996000	2552	dbSNP
rs1262596513	2556	dbSNP
rs1239905259	2560	dbSNP
rs1321322566	2564	dbSNP
rs543288307	2565	dbSNP
rs1234902655	2566	dbSNP
rs1355863097	2582	dbSNP
rs1297444216	2591	dbSNP
rs1380482733	2605	dbSNP
rs1046408072	2611	dbSNP
rs190721997	2613	dbSNP
rs1376470769	2620	dbSNP
rs989865139	2622	dbSNP
rs1457021528	2630	dbSNP
rs1391830956	2632	dbSNP
rs1166652743	2646	dbSNP
rs149274455	2653	dbSNP
rs1307018874	2655	dbSNP
rs1419055191	2662	dbSNP
rs1193045859	2663	dbSNP
rs560463534	2672	dbSNP
rs1352421418	2677	dbSNP
rs1205781198	2683	dbSNP
rs1215082428	2684	dbSNP
rs1488237619	2694	dbSNP
rs899242854	2697	dbSNP
rs1215807274	2699	dbSNP
rs1486191904	2702	dbSNP
rs1277364365	2721	dbSNP
rs996384374	2723	dbSNP
rs1209796971	2725	dbSNP
rs1296292980	2729	dbSNP
rs1385665411	2742	dbSNP
rs1236090515	2745	dbSNP
rs1368165930	2748	dbSNP
rs1327441722	2750	dbSNP
rs1029145729	2751	dbSNP
rs1399138662	2762	dbSNP
rs750769084	2770	dbSNP
rs567638889	2774	dbSNP
rs182905259	2781	dbSNP
rs527633885	2783	dbSNP
rs373242697	2784	dbSNP
rs1009533150	2790	dbSNP
rs374545458	2795	dbSNP
rs1047681552	2797	dbSNP
rs1251241832	2805	dbSNP
rs757378034	2808	dbSNP
rs978543401	2809	dbSNP
rs1415005340	2838	dbSNP
rs1032757260	2843	dbSNP
rs772220406	2847	dbSNP
rs1005960228	2852	dbSNP
rs143429471	2859	dbSNP
rs147987584	2860	dbSNP
rs1451505185	2865	dbSNP
rs1368094468	2872	dbSNP
rs1304946212	2879	dbSNP
rs1357231385	2884	dbSNP
rs991310959	2888	dbSNP
rs917053524	2891	dbSNP
rs950017688	2894	dbSNP
rs983068271	2896	dbSNP
rs1168951911	2904	dbSNP
rs1434677417	2907	dbSNP
rs899889642	2908	dbSNP
rs11605890	2913	dbSNP
rs1175576061	2922	dbSNP
rs1454809920	2929	dbSNP
rs1232448970	2939	dbSNP
rs1179942055	2947	dbSNP
rs1331703738	2950	dbSNP
rs541320654	2954	dbSNP
rs1375479427	2958	dbSNP
rs1209934144	2959	dbSNP
rs761570250	2961	dbSNP
rs996897430	2964	dbSNP
rs940723549	2973	dbSNP
rs1234375781	2975	dbSNP
rs1469725873	2976	dbSNP
rs1029750614	2982	dbSNP
rs758728471	2988	dbSNP
rs559645962	2989	dbSNP
rs1032330863	2999	dbSNP
rs796770807	3002	dbSNP
rs957673177	3012	dbSNP
rs780607732	3034	dbSNP
rs1009153498	3038	dbSNP
rs990203555	3040	dbSNP
rs1439986495	3045	dbSNP
rs142645503	3049	dbSNP

- Genes & development, 2011

MicroRNAs are important regulators in many cellular processes, including stem cell self-renewal. Recent studies demonstrated their function as pluripotency factors with the capacity for somatic cell reprogramming. However, their role in human embryonic stem (ES) cells (hESCs) remains poorly understood, partially due to the lack of genome-wide strategies to identify their targets. Here, we performed comprehensive microRNA profiling in hESCs and in purified neural and mesenchymal derivatives. Using a combination of AGO cross-linking and microRNA perturbation experiments, together with computational prediction, we identified the targets of the miR-302/367 cluster, the most abundant microRNAs in hESCs. Functional studies identified novel roles of miR-302/367 in maintaining pluripotency and regulating hESC differentiation. We show that in addition to its role in TGF-beta signaling, miR-302/367 promotes bone morphogenetic protein (BMP) signaling by targeting BMP inhibitors TOB2, DAZAP2, and SLAIN1. This study broadens our understanding of microRNA function in hESCs and is a valuable resource for future studies in this area.