pre-miRNA Information | |
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pre-miRNA | hsa-mir-497 |
Genomic Coordinates | chr17: 7017911 - 7018022 |
Synonyms | MIRN497, hsa-mir-497, MIR497 |
Description | Homo sapiens miR-497 stem-loop |
Comment | None |
RNA Secondary Structure | ![]() |
Associated Diseases | ![]() |
Mature miRNA Information | |||||||||||||||||||||||||||||
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Mature miRNA | hsa-miR-497-3p | ||||||||||||||||||||||||||||
Sequence | 64| CAAACCACACUGUGGUGUUAGA |85 | ||||||||||||||||||||||||||||
Evidence | Experimental | ||||||||||||||||||||||||||||
Experiments | Cloned | ||||||||||||||||||||||||||||
Editing Events in miRNAs |
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SNPs in miRNA |
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Putative Targets |
miRNA Expression profile | |
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Human miRNA Tissue Atlas | |
Circulating MicroRNA Expression Profiling |
Gene Information | |||||||||||||||||||||
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Gene Symbol | ABCG2 | ||||||||||||||||||||
Synonyms | ABC15, ABCP, BCRP, BCRP1, BMDP, CD338, CDw338, EST157481, GOUT1, MRX, MXR, MXR-1, MXR1, UAQTL1 | ||||||||||||||||||||
Description | ATP binding cassette subfamily G member 2 (Junior blood group) | ||||||||||||||||||||
Transcript | NM_004827 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on ABCG2 | |||||||||||||||||||||
3'UTR of ABCG2 (miRNA target sites are highlighted) |
>ABCG2|NM_004827|3'UTR 1 ATTTCCCCTTAATTCAGTATGATTTATCCTCACATAAAAAAGAAGCACTTTGATTGAAGTATTCAATCAAGTTTTTTTGT 81 TGTTTTCTGTTCCCTTGCCATCACACTGTTGCACAGCAGCAATTGTTTTAAAGAGATACATTTTTAGAAATCACAACAAA 161 CTGAATTAAACATGAAAGAACCCAAGACATCATGTATCGCATATTAGTTAATCTCCTCAGACAGTAACCATGGGGAAGAA 241 ATCTGGTCTAATTTATTAATCTAAAAAAGGAGAATTGAATTCTGGAAACTCCTGACAAGTTATTACTGTCTCTGGCATTT 321 GTTTCCTCATCTTTAAAATGAATAGGTAGGTTAGTAGCCCTTCAGTCTTAATACTTTATGATGCTATGGTTTGCCATTAT 401 TTAATAAATGACAAATGTATTAATGCTATACTGGAAATGTAAAATTGAAAATATGTTGGAAAAAAGATTCTGTCTTATAG 481 GGTAAAAAAAGCCACCGTGATAGAAAAAAAATCTTTTTGATAAGCACATTAAAGTTAATAGAACTTACTGATATTCCTGT 561 CTAGTGGTATAATATCTCAGGAATCTTGGCTGAGGGTTTGGAACTGTGGGTAGAGTAGAGGGCCAGGAGTCCAGTAATAG 641 AATTCTTGCACCATTTCTGGAACATTCTAGCTCTGGGAGGTCACGTAACCTTCTTGGGGTAGTTCAGTGGTTTAGTGGTT 721 TATAATCCAGGTGTGCGTCAGAATCATCTGAGGAACTTTGCTAAAATACAAAAATCTGGCCTAAGTAGCTCCAGATCTAC 801 CTTCATAAAGGAATCTGACCACTCCTGGATTTGGTAATTTCCAAGTTCTGAAAATTTTACTTAGGATTTAATAACTATTA 881 ACATCTGTCCCTACATAGGTTTTCTTTCCTACTTATATACCTTATGTTCTCTTCATTCTAACCTTCATCAGTAATAGGGA 961 AATGTTTTAATTTTATTTTTTTAGTTGAAGGGTAATGTACCAAAAAATATAGTTCAGTGAATTAAAATGAACACACATGT 1041 GCAACCATCAATTCAGGTCAAGAAATAGAAGATTGTAGCACACAAAAGCCTACTCAGCCATTCTCCCAGTCACTACTTCC 1121 TTCCTTACCCCTGGGTTATTTTTGAAATGACACTTGATGTATTTCCCTCTGTTGCTGTTATGAGAACATTGCTACAGCCA 1201 AGTGTTGTGTTTCTGTGTGCATAGGTTGATACTTAATTATCTCCCCACTTTTTAATAAACTTTTAATTTGGAAATAATTT 1281 TAGATTGACAGAAAAGTTGCAAAGATAGTGAGGAAAGTTCCTGTCTACTCTTTGCTCAGCTTCCCTTAATGTTAACATTT 1361 TATATAGCAAGATGCATTTGTCAAAGCTAACAAGTTAACATTGGTACAATCACTGTTAATTAAACTGCACACAATATTCA 1441 GATTTCACCACTTTTCCACTAATATTCTTTCATTGTTCTAGGATTCAATTCAGGAGACCACATTTCATCTAGCCCTCTTT 1521 TTTAAAAGTAAATACTTTTCAGCACTTACAGGAGTTAACTGAGCTGGGGCATCATGGTGTATAGACGCCCTGACACTGGT 1601 CATCTTGGAATTCATTTAGTTTGTCAGTGGGTGCCCTGACATTCTGTCACAACATCAATTTGGGAACATGGCATTATATT 1681 TTTATCTTTGAACTTTTTTCTTTTTGGATGACATTTGATTAATGCGTCATCTTGGAACACATTATCTTTTTTCTTGGTTA 1761 TGTGATCAGGAAGATTAATCAGTTTTTCCTGTTCTTGGTATAATTCCTGCTTTTCACATACCTGTCCCTTACAGTTCTCT 1841 ATATATACCCTTCCCTTATTACACAGAGAGAAATATCTATCTATACTTTTTACACAAAATATACTTCAAAAGAAACAAAA 1921 CAGCCACAATTATTAACTTTTTAAATAAATGAGAATTTAATTATATCCTAAAAAAAAAAAAAAA Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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DRVs in gene 3'UTRs | |||||||||||||||||||||
SNPs in gene 3'UTRs |
Experimental Support 1 for Functional miRNA-Target Interaction | |||||||
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miRNA:Target | ---- | ||||||
Validation Method |
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Conditions | hESCs (WA-09) | ||||||
Disease | 9429.0 | ||||||
Location of target site | 3'UTR | ||||||
Tools used in this research | TargetScan , miRTarCLIP , Piranha | ||||||
Original Description (Extracted from the article) |
...
"PAR-CLIP data was present in SRR359787. RNA binding protein: AGO2. Condition:4-thiouridine
... - Lipchina I; Elkabetz Y; Hafner M; Sheridan et al., 2011, Genes & development. |
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miRNA-target interactions (Provided by authors) |
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Article |
- Lipchina I; Elkabetz Y; Hafner M; Sheridan et al. - Genes & development, 2011
MicroRNAs are important regulators in many cellular processes, including stem cell self-renewal. Recent studies demonstrated their function as pluripotency factors with the capacity for somatic cell reprogramming. However, their role in human embryonic stem (ES) cells (hESCs) remains poorly understood, partially due to the lack of genome-wide strategies to identify their targets. Here, we performed comprehensive microRNA profiling in hESCs and in purified neural and mesenchymal derivatives. Using a combination of AGO cross-linking and microRNA perturbation experiments, together with computational prediction, we identified the targets of the miR-302/367 cluster, the most abundant microRNAs in hESCs. Functional studies identified novel roles of miR-302/367 in maintaining pluripotency and regulating hESC differentiation. We show that in addition to its role in TGF-beta signaling, miR-302/367 promotes bone morphogenetic protein (BMP) signaling by targeting BMP inhibitors TOB2, DAZAP2, and SLAIN1. This study broadens our understanding of microRNA function in hESCs and is a valuable resource for future studies in this area.
LinkOut: [PMID: 22012620]
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CLIP-seq Support 1 for dataset SRR359787 | |
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Method / RBP | PAR-CLIP / AGO2 |
Cell line / Condition | hESCs (WA-09) / 4-thiouridine, RNase T1 |
Location of target site | ENST00000515655.1 | 3UTR | UUGGGGUAGUUCAGUGGUUUAGUGGUUU |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 22012620 / SRX103431 |
CLIP-seq Viewer | Link |
MiRNA-Target Expression Profile | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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MiRNA-Target Expression Profile (TCGA) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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95 hsa-miR-497-3p Target Genes:
Functional analysis:
ID![]() |
Target | Description | Validation methods |
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Strong evidence | Less strong evidence | |||||||||||
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MIRT092955 | CYP2U1 | cytochrome P450 family 2 subfamily U member 1 | ![]() |
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2 | 4 | ||||||
MIRT124568 | PRRC2B | proline rich coiled-coil 2B | ![]() |
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2 | 2 | ||||||
MIRT125196 | EIF1AX | eukaryotic translation initiation factor 1A, X-linked | ![]() |
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2 | 4 | ||||||
MIRT147296 | KPNA2 | karyopherin subunit alpha 2 | ![]() |
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2 | 8 | ||||||
MIRT163999 | KIAA1109 | KIAA1109 | ![]() |
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2 | 4 | ||||||
MIRT252495 | NWD1 | NACHT and WD repeat domain containing 1 | ![]() |
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2 | 2 | ||||||
MIRT357969 | GRPEL2 | GrpE like 2, mitochondrial | ![]() |
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2 | 2 | ||||||
MIRT443007 | TRIOBP | TRIO and F-actin binding protein | ![]() |
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2 | 2 | ||||||
MIRT443524 | NETO1 | neuropilin and tolloid like 1 | ![]() |
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2 | 2 | ||||||
MIRT443573 | EVX2 | even-skipped homeobox 2 | ![]() |
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2 | 2 | ||||||
MIRT443656 | BACH1 | BTB domain and CNC homolog 1 | ![]() |
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2 | 2 | ||||||
MIRT460670 | KRT10 | keratin 10 | ![]() |
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2 | 8 | ||||||
MIRT464761 | UBE2N | ubiquitin conjugating enzyme E2 N | ![]() |
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2 | 2 | ||||||
MIRT465032 | LINC00598 | long intergenic non-protein coding RNA 598 | ![]() |
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2 | 2 | ||||||
MIRT465040 | TTC39C | tetratricopeptide repeat domain 39C | ![]() |
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2 | 2 | ||||||
MIRT468667 | SEC62 | SEC62 homolog, preprotein translocation factor | ![]() |
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2 | 2 | ||||||
MIRT473694 | MAPK8 | mitogen-activated protein kinase 8 | ![]() |
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2 | 4 | ||||||
MIRT477618 | EFNA3 | ephrin A3 | ![]() |
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2 | 2 | ||||||
MIRT480506 | C11orf57 | chromosome 11 open reading frame 57 | ![]() |
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2 | 2 | ||||||
MIRT480592 | BUB3 | BUB3, mitotic checkpoint protein | ![]() |
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2 | 2 | ||||||
MIRT486915 | ZNF398 | zinc finger protein 398 | ![]() |
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2 | 6 | ||||||
MIRT487770 | ANKEF1 | ankyrin repeat and EF-hand domain containing 1 | ![]() |
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2 | 16 | ||||||
MIRT493265 | MDFIC | MyoD family inhibitor domain containing | ![]() |
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2 | 2 | ||||||
MIRT495271 | SLC1A2 | solute carrier family 1 member 2 | ![]() |
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2 | 4 | ||||||
MIRT495309 | CHST12 | carbohydrate sulfotransferase 12 | ![]() |
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2 | 2 | ||||||
MIRT496681 | DPP6 | dipeptidyl peptidase like 6 | ![]() |
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2 | 4 | ||||||
MIRT496891 | FOXP1 | forkhead box P1 | ![]() |
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2 | 2 | ||||||
MIRT497330 | IRF4 | interferon regulatory factor 4 | ![]() |
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2 | 2 | ||||||
MIRT498272 | KIAA1644 | KIAA1644 | ![]() |
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2 | 2 | ||||||
MIRT498634 | CHD4 | chromodomain helicase DNA binding protein 4 | ![]() |
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2 | 10 | ||||||
MIRT500581 | USP53 | ubiquitin specific peptidase 53 | ![]() |
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2 | 2 | ||||||
MIRT500751 | TMPPE | transmembrane protein with metallophosphoesterase domain | ![]() |
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2 | 6 | ||||||
MIRT509668 | ZNF354B | zinc finger protein 354B | ![]() |
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2 | 10 | ||||||
MIRT510919 | PSMA2 | proteasome subunit alpha 2 | ![]() |
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2 | 4 | ||||||
MIRT519118 | CEP76 | centrosomal protein 76 | ![]() |
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2 | 2 | ||||||
MIRT526193 | ABCG2 | ATP binding cassette subfamily G member 2 (Junior blood group) | ![]() |
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2 | 2 | ||||||
MIRT526746 | HLA-DOB | major histocompatibility complex, class II, DO beta | ![]() |
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2 | 2 | ||||||
MIRT527270 | FBLN2 | fibulin 2 | ![]() |
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2 | 2 | ||||||
MIRT528198 | PLEKHM2 | pleckstrin homology and RUN domain containing M2 | ![]() |
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2 | 2 | ||||||
MIRT528330 | TBC1D22B | TBC1 domain family member 22B | ![]() |
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2 | 2 | ||||||
MIRT530346 | GABRB3 | gamma-aminobutyric acid type A receptor beta3 subunit | ![]() |
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2 | 2 | ||||||
MIRT533627 | TMX3 | thioredoxin related transmembrane protein 3 | ![]() |
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2 | 2 | ||||||
MIRT533738 | TMEM200C | transmembrane protein 200C | ![]() |
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2 | 2 | ||||||
MIRT533779 | TMEM133 | transmembrane protein 133 | ![]() |
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2 | 2 | ||||||
MIRT534317 | SKIDA1 | SKI/DACH domain containing 1 | ![]() |
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2 | 2 | ||||||
MIRT538438 | COG5 | component of oligomeric golgi complex 5 | ![]() |
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2 | 2 | ||||||
MIRT539156 | AREL1 | apoptosis resistant E3 ubiquitin protein ligase 1 | ![]() |
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2 | 2 | ||||||
MIRT539474 | ADARB2 | adenosine deaminase, RNA specific B2 (inactive) | ![]() |
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2 | 2 | ||||||
MIRT539620 | SHISA9 | shisa family member 9 | ![]() |
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2 | 2 | ||||||
MIRT539650 | BUB1 | BUB1 mitotic checkpoint serine/threonine kinase | ![]() |
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2 | 2 | ||||||
MIRT540346 | OPHN1 | oligophrenin 1 | ![]() |
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2 | 2 | ||||||
MIRT540412 | PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | ![]() |
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2 | 2 | ||||||
MIRT541200 | HSP90AA1 | heat shock protein 90 alpha family class A member 1 | ![]() |
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2 | 2 | ||||||
MIRT541395 | CDC27 | cell division cycle 27 | ![]() |
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2 | 2 | ||||||
MIRT546443 | SNX5 | sorting nexin 5 | ![]() |
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2 | 2 | ||||||
MIRT547369 | MSI2 | musashi RNA binding protein 2 | ![]() |
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2 | 2 | ||||||
MIRT553288 | TSPAN3 | tetraspanin 3 | ![]() |
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2 | 2 | ||||||
MIRT554402 | SERP1 | stress associated endoplasmic reticulum protein 1 | ![]() |
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2 | 2 | ||||||
MIRT557822 | FOXN2 | forkhead box N2 | ![]() |
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2 | 2 | ||||||
MIRT568530 | ANP32E | acidic nuclear phosphoprotein 32 family member E | ![]() |
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2 | 2 | ||||||
MIRT569508 | THYN1 | thymocyte nuclear protein 1 | ![]() |
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2 | 2 | ||||||
MIRT570707 | FAM69A | family with sequence similarity 69 member A | ![]() |
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2 | 2 | ||||||
MIRT608376 | PIWIL2 | piwi like RNA-mediated gene silencing 2 | ![]() |
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2 | 2 | ||||||
MIRT608483 | NKTR | natural killer cell triggering receptor | ![]() |
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2 | 6 | ||||||
MIRT613533 | TRA2B | transformer 2 beta homolog | ![]() |
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2 | 2 | ||||||
MIRT616601 | ELP2 | elongator acetyltransferase complex subunit 2 | ![]() |
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2 | 2 | ||||||
MIRT618166 | DUSP18 | dual specificity phosphatase 18 | ![]() |
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2 | 2 | ||||||
MIRT632059 | CEP135 | centrosomal protein 135 | ![]() |
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2 | 2 | ||||||
MIRT647379 | ZDHHC23 | zinc finger DHHC-type containing 23 | ![]() |
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2 | 2 | ||||||
MIRT648366 | POTED | POTE ankyrin domain family member D | ![]() |
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2 | 2 | ||||||
MIRT651075 | ZNF518B | zinc finger protein 518B | ![]() |
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2 | 4 | ||||||
MIRT653618 | SLC30A4 | solute carrier family 30 member 4 | ![]() |
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2 | 2 | ||||||
MIRT653636 | SLC30A1 | solute carrier family 30 member 1 | ![]() |
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2 | 2 | ||||||
MIRT654895 | POU2F1 | POU class 2 homeobox 1 | ![]() |
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2 | 2 | ||||||
MIRT656232 | MFSD6 | major facilitator superfamily domain containing 6 | ![]() |
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2 | 2 | ||||||
MIRT659880 | CAPRIN1 | cell cycle associated protein 1 | ![]() |
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2 | 2 | ||||||
MIRT660526 | ARL4C | ADP ribosylation factor like GTPase 4C | ![]() |
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2 | 2 | ||||||
MIRT666286 | SLC30A3 | solute carrier family 30 member 3 | ![]() |
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2 | 2 | ||||||
MIRT686808 | SNX2 | sorting nexin 2 | ![]() |
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2 | 4 | ||||||
MIRT695302 | TK1 | thymidine kinase 1 | ![]() |
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2 | 2 | ||||||
MIRT699737 | SERINC3 | serine incorporator 3 | ![]() |
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2 | 2 | ||||||
MIRT700794 | PIAS2 | protein inhibitor of activated STAT 2 | ![]() |
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2 | 2 | ||||||
MIRT712270 | PPP1CB | protein phosphatase 1 catalytic subunit beta | ![]() |
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2 | 2 | ||||||
MIRT712617 | KNSTRN | kinetochore localized astrin/SPAG5 binding protein | ![]() |
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2 | 2 | ||||||
MIRT714264 | RPL10A | ribosomal protein L10a | ![]() |
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2 | 2 | ||||||
MIRT715072 | TMTC1 | transmembrane and tetratricopeptide repeat containing 1 | ![]() |
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2 | 2 | ||||||
MIRT715386 | TADA3 | transcriptional adaptor 3 | ![]() |
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2 | 2 | ||||||
MIRT716397 | NPAS1 | neuronal PAS domain protein 1 | ![]() |
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2 | 2 | ||||||
MIRT725328 | NFASC | neurofascin | ![]() |
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2 | 2 | ||||||
MIRT725503 | GANAB | glucosidase II alpha subunit | ![]() |
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2 | 2 | ||||||
MIRT732913 | IRAK2 | interleukin 1 receptor associated kinase 2 | ![]() |
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3 | 0 | |||||
MIRT734890 | SMAD3 | SMAD family member 3 | ![]() |
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3 | 0 | |||||
MIRT737328 | LINC02476 | long intergenic non-protein coding RNA 2476 | ![]() |
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3 | 0 | |||||
MIRT737544 | MALAT1 | metastasis associated lung adenocarcinoma transcript 1 (non-protein coding) | ![]() |
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4 | 0 | ||||
MIRT755545 | PAK1 | p21 (RAC1) activated kinase 1 | 3 | 1 |
miRNA-Drug Associations | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
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miRNA-Drug Resistance Associations | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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