pre-miRNA Information
pre-miRNA hsa-mir-497   
Genomic Coordinates chr17: 7017911 - 7018022
Synonyms MIRN497, hsa-mir-497, MIR497
Description Homo sapiens miR-497 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-497-3p
Sequence 64| CAAACCACACUGUGGUGUUAGA |85
Evidence Experimental
Experiments Cloned
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 3 17 - 7017957 29233923 MiREDiBase
A-to-I 4 17 - 7017956 29233923 MiREDiBase
A-to-I 20 17 - 7017940 24964909, 25521855, 27229138, 29165639, 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1413601274 5 dbSNP
rs1028648384 6 dbSNP
rs1479092960 9 dbSNP
rs1261056598 10 dbSNP
rs997278260 11 dbSNP
rs1324708562 13 dbSNP
rs755634302 21 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol ABCG2   
Synonyms ABC15, ABCP, BCRP, BCRP1, BMDP, CD338, CDw338, EST157481, GOUT1, MRX, MXR, MXR-1, MXR1, UAQTL1
Description ATP binding cassette subfamily G member 2 (Junior blood group)
Transcript NM_004827   
Expression
Putative miRNA Targets on ABCG2
3'UTR of ABCG2
(miRNA target sites are highlighted)
>ABCG2|NM_004827|3'UTR
   1 ATTTCCCCTTAATTCAGTATGATTTATCCTCACATAAAAAAGAAGCACTTTGATTGAAGTATTCAATCAAGTTTTTTTGT
  81 TGTTTTCTGTTCCCTTGCCATCACACTGTTGCACAGCAGCAATTGTTTTAAAGAGATACATTTTTAGAAATCACAACAAA
 161 CTGAATTAAACATGAAAGAACCCAAGACATCATGTATCGCATATTAGTTAATCTCCTCAGACAGTAACCATGGGGAAGAA
 241 ATCTGGTCTAATTTATTAATCTAAAAAAGGAGAATTGAATTCTGGAAACTCCTGACAAGTTATTACTGTCTCTGGCATTT
 321 GTTTCCTCATCTTTAAAATGAATAGGTAGGTTAGTAGCCCTTCAGTCTTAATACTTTATGATGCTATGGTTTGCCATTAT
 401 TTAATAAATGACAAATGTATTAATGCTATACTGGAAATGTAAAATTGAAAATATGTTGGAAAAAAGATTCTGTCTTATAG
 481 GGTAAAAAAAGCCACCGTGATAGAAAAAAAATCTTTTTGATAAGCACATTAAAGTTAATAGAACTTACTGATATTCCTGT
 561 CTAGTGGTATAATATCTCAGGAATCTTGGCTGAGGGTTTGGAACTGTGGGTAGAGTAGAGGGCCAGGAGTCCAGTAATAG
 641 AATTCTTGCACCATTTCTGGAACATTCTAGCTCTGGGAGGTCACGTAACCTTCTTGGGGTAGTTCAGTGGTTTAGTGGTT
 721 TATAATCCAGGTGTGCGTCAGAATCATCTGAGGAACTTTGCTAAAATACAAAAATCTGGCCTAAGTAGCTCCAGATCTAC
 801 CTTCATAAAGGAATCTGACCACTCCTGGATTTGGTAATTTCCAAGTTCTGAAAATTTTACTTAGGATTTAATAACTATTA
 881 ACATCTGTCCCTACATAGGTTTTCTTTCCTACTTATATACCTTATGTTCTCTTCATTCTAACCTTCATCAGTAATAGGGA
 961 AATGTTTTAATTTTATTTTTTTAGTTGAAGGGTAATGTACCAAAAAATATAGTTCAGTGAATTAAAATGAACACACATGT
1041 GCAACCATCAATTCAGGTCAAGAAATAGAAGATTGTAGCACACAAAAGCCTACTCAGCCATTCTCCCAGTCACTACTTCC
1121 TTCCTTACCCCTGGGTTATTTTTGAAATGACACTTGATGTATTTCCCTCTGTTGCTGTTATGAGAACATTGCTACAGCCA
1201 AGTGTTGTGTTTCTGTGTGCATAGGTTGATACTTAATTATCTCCCCACTTTTTAATAAACTTTTAATTTGGAAATAATTT
1281 TAGATTGACAGAAAAGTTGCAAAGATAGTGAGGAAAGTTCCTGTCTACTCTTTGCTCAGCTTCCCTTAATGTTAACATTT
1361 TATATAGCAAGATGCATTTGTCAAAGCTAACAAGTTAACATTGGTACAATCACTGTTAATTAAACTGCACACAATATTCA
1441 GATTTCACCACTTTTCCACTAATATTCTTTCATTGTTCTAGGATTCAATTCAGGAGACCACATTTCATCTAGCCCTCTTT
1521 TTTAAAAGTAAATACTTTTCAGCACTTACAGGAGTTAACTGAGCTGGGGCATCATGGTGTATAGACGCCCTGACACTGGT
1601 CATCTTGGAATTCATTTAGTTTGTCAGTGGGTGCCCTGACATTCTGTCACAACATCAATTTGGGAACATGGCATTATATT
1681 TTTATCTTTGAACTTTTTTCTTTTTGGATGACATTTGATTAATGCGTCATCTTGGAACACATTATCTTTTTTCTTGGTTA
1761 TGTGATCAGGAAGATTAATCAGTTTTTCCTGTTCTTGGTATAATTCCTGCTTTTCACATACCTGTCCCTTACAGTTCTCT
1841 ATATATACCCTTCCCTTATTACACAGAGAGAAATATCTATCTATACTTTTTACACAAAATATACTTCAAAAGAAACAAAA
1921 CAGCCACAATTATTAACTTTTTAAATAAATGAGAATTTAATTATATCCTAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' agAUUGUGGUGUCA---CACCAAAc 5'
            ||:: | :::||   ||||||| 
Target 5' ggTAGTTCAGTGGTTTAGTGGTTTa 3'
698 - 722 152.00 -8.70
2
miRNA  3' agAUUGUGG-----UGUCACACCAAAc 5'
            |||:||:     |:: | |||||| 
Target 5' ctTAATACTTTATGATGCTATGGTTTg 3'
367 - 393 128.00 -12.30
3
miRNA  3' agAUUGUGGUGUCA---CACCAAAc 5'
            |:|:|:: | ||   ||||| | 
Target 5' acTGATATTCCTGTCTAGTGGTATa 3'
547 - 571 124.00 -11.42
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30487559 7 COSMIC
COSN30142060 42 COSMIC
COSN31516456 56 COSMIC
COSN31530325 59 COSMIC
COSN30485047 87 COSMIC
COSN19657566 121 COSMIC
COSN21930573 122 COSMIC
COSN7645170 137 COSMIC
COSN21009429 159 COSMIC
COSN26878501 213 COSMIC
COSN25227770 221 COSMIC
COSN8349919 292 COSMIC
COSN5579688 302 COSMIC
COSN5064731 496 COSMIC
COSN28162834 671 COSMIC
COSN25562351 1002 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs965714244 11 dbSNP
rs374778497 12 dbSNP
rs772440727 15 dbSNP
rs1225095319 19 dbSNP
rs748337295 26 dbSNP
rs1313367759 27 dbSNP
rs571120570 33 dbSNP
rs1314067220 34 dbSNP
rs759139218 35 dbSNP
rs776950657 47 dbSNP
rs573723198 58 dbSNP
rs555638039 62 dbSNP
rs1398547984 64 dbSNP
rs370090039 66 dbSNP
rs1327133995 71 dbSNP
rs904284717 71 dbSNP
rs566792922 72 dbSNP
rs1434353323 80 dbSNP
rs1272151455 89 dbSNP
rs1044259558 107 dbSNP
rs977772886 109 dbSNP
rs1212559694 111 dbSNP
rs1467490828 122 dbSNP
rs558043917 123 dbSNP
rs771442619 136 dbSNP
rs967768648 138 dbSNP
rs1315801376 149 dbSNP
rs539777131 155 dbSNP
rs1273693503 170 dbSNP
rs569154459 185 dbSNP
rs1196058131 188 dbSNP
rs867937528 198 dbSNP
rs1475574309 199 dbSNP
rs1192436641 201 dbSNP
rs1316765343 203 dbSNP
rs45566442 217 dbSNP
rs944687411 221 dbSNP
rs1225622428 222 dbSNP
rs550999353 233 dbSNP
rs552242687 237 dbSNP
rs1035254919 241 dbSNP
rs1403692581 243 dbSNP
rs539036343 245 dbSNP
rs1327099993 247 dbSNP
rs1399671696 252 dbSNP
rs184240013 263 dbSNP
rs574709965 269 dbSNP
rs897119621 275 dbSNP
rs568545554 280 dbSNP
rs1037522707 286 dbSNP
rs1327925852 299 dbSNP
rs941463222 308 dbSNP
rs1050458763 315 dbSNP
rs1447052849 333 dbSNP
rs1215468981 344 dbSNP
rs1156677195 345 dbSNP
rs888522672 349 dbSNP
rs548878030 351 dbSNP
rs920711624 356 dbSNP
rs973196182 361 dbSNP
rs1408296648 363 dbSNP
rs140188296 364 dbSNP
rs1242457523 375 dbSNP
rs907793434 377 dbSNP
rs1452076189 379 dbSNP
rs992663134 384 dbSNP
rs1255436892 386 dbSNP
rs1214923693 390 dbSNP
rs931781341 396 dbSNP
rs1259262427 403 dbSNP
rs1138276 407 dbSNP
rs1218419702 411 dbSNP
rs773678078 412 dbSNP
rs1296587335 419 dbSNP
rs1377440761 421 dbSNP
rs566569140 425 dbSNP
rs1334646094 426 dbSNP
rs1339617133 430 dbSNP
rs1242572170 441 dbSNP
rs527497846 448 dbSNP
rs1232136943 452 dbSNP
rs1373366122 454 dbSNP
rs1350809305 458 dbSNP
rs1304278237 460 dbSNP
rs944376136 465 dbSNP
rs1486482980 467 dbSNP
rs748593987 471 dbSNP
rs977720641 475 dbSNP
rs967801174 477 dbSNP
rs1441029498 490 dbSNP
rs1021403533 491 dbSNP
rs546688633 492 dbSNP
rs1364811814 495 dbSNP
rs530160050 496 dbSNP
rs139685238 497 dbSNP
rs1011072921 512 dbSNP
rs1396961849 512 dbSNP
rs78525495 517 dbSNP
rs778502653 530 dbSNP
rs1401258041 531 dbSNP
rs990965631 539 dbSNP
rs959538639 541 dbSNP
rs1394023769 542 dbSNP
rs377236890 544 dbSNP
rs1377479148 555 dbSNP
rs560425458 569 dbSNP
rs1445942841 572 dbSNP
rs1306541585 587 dbSNP
rs1009121872 592 dbSNP
rs1233583777 595 dbSNP
rs1255004876 606 dbSNP
rs551683010 609 dbSNP
rs1345387334 613 dbSNP
rs533313831 618 dbSNP
rs1172699317 625 dbSNP
rs562336750 628 dbSNP
rs1457761250 633 dbSNP
rs1432310395 636 dbSNP
rs1462500764 648 dbSNP
rs754381375 663 dbSNP
rs932027380 667 dbSNP
rs1454726152 671 dbSNP
rs561129046 676 dbSNP
rs544201888 684 dbSNP
rs749004062 685 dbSNP
rs1400757958 699 dbSNP
rs1015635324 705 dbSNP
rs1037787805 706 dbSNP
rs940779478 711 dbSNP
rs907678854 722 dbSNP
rs1188629376 723 dbSNP
rs573606248 732 dbSNP
rs150093758 736 dbSNP
rs888552090 737 dbSNP
rs960205520 739 dbSNP
rs540390670 743 dbSNP
rs1317654231 748 dbSNP
rs140657468 749 dbSNP
rs996021200 753 dbSNP
rs1208930689 769 dbSNP
rs900296985 770 dbSNP
rs1448782 781 dbSNP
rs1468967225 782 dbSNP
rs1281083863 788 dbSNP
rs1040607892 792 dbSNP
rs557958071 796 dbSNP
rs1190630904 799 dbSNP
rs1265344567 822 dbSNP
rs980163929 824 dbSNP
rs968447882 860 dbSNP
rs1424136592 864 dbSNP
rs1306826307 867 dbSNP
rs944674644 871 dbSNP
rs1396512958 872 dbSNP
rs923842016 878 dbSNP
rs191744769 881 dbSNP
rs1458334232 883 dbSNP
rs1009951830 885 dbSNP
rs1292501995 886 dbSNP
rs1387913429 887 dbSNP
rs1383609832 890 dbSNP
rs779635621 895 dbSNP
rs1278376667 898 dbSNP
rs1340325765 911 dbSNP
rs1042061740 916 dbSNP
rs755744350 918 dbSNP
rs144758913 920 dbSNP
rs955784040 921 dbSNP
rs1322916861 922 dbSNP
rs1031148030 935 dbSNP
rs1383703806 939 dbSNP
rs750259790 946 dbSNP
rs575932372 948 dbSNP
rs1217650585 952 dbSNP
rs1009088776 955 dbSNP
rs1477376286 957 dbSNP
rs890685633 959 dbSNP
rs1419753109 963 dbSNP
rs1424368614 965 dbSNP
rs1412467072 982 dbSNP
rs767296296 1000 dbSNP
rs915004660 1001 dbSNP
rs1050731810 1015 dbSNP
rs996575915 1019 dbSNP
rs551167682 1027 dbSNP
rs1298434976 1030 dbSNP
rs147591922 1031 dbSNP
rs1397737295 1038 dbSNP
rs535864925 1051 dbSNP
rs146139545 1054 dbSNP
rs568428797 1055 dbSNP
rs1315267937 1056 dbSNP
rs547101502 1057 dbSNP
rs1448784 1066 dbSNP
rs1371812445 1069 dbSNP
rs982677882 1072 dbSNP
rs751386576 1073 dbSNP
rs1318846572 1074 dbSNP
rs1015834807 1075 dbSNP
rs1285596936 1076 dbSNP
rs1257176552 1082 dbSNP
rs1005570023 1085 dbSNP
rs952659072 1098 dbSNP
rs1056875560 1099 dbSNP
rs538617995 1108 dbSNP
rs765388040 1111 dbSNP
rs1479738153 1112 dbSNP
rs927195130 1115 dbSNP
rs1253908649 1118 dbSNP
rs1441012683 1120 dbSNP
rs1158789291 1125 dbSNP
rs1379152284 1127 dbSNP
rs1249531481 1130 dbSNP
rs980084096 1133 dbSNP
rs1229443896 1144 dbSNP
rs566672143 1152 dbSNP
rs1360134915 1156 dbSNP
rs759484000 1159 dbSNP
rs1318520168 1160 dbSNP
rs111368152 1181 dbSNP
rs74362438 1182 dbSNP
rs1292405061 1187 dbSNP
rs867410008 1192 dbSNP
rs1009129393 1197 dbSNP
rs1376096386 1198 dbSNP
rs1448160187 1199 dbSNP
rs1308670140 1219 dbSNP
rs776827375 1222 dbSNP
rs1236799726 1224 dbSNP
rs1334444740 1225 dbSNP
rs368624404 1229 dbSNP
rs1209089110 1231 dbSNP
rs1235506292 1232 dbSNP
rs1393624868 1236 dbSNP
rs1459090675 1239 dbSNP
rs1299393101 1241 dbSNP
rs1237089990 1242 dbSNP
rs1437229538 1242 dbSNP
rs946393172 1247 dbSNP
rs556533547 1251 dbSNP
rs1417806329 1253 dbSNP
rs1174472816 1254 dbSNP
rs1054714130 1256 dbSNP
rs188090649 1260 dbSNP
rs927688791 1265 dbSNP
rs1331204636 1271 dbSNP
rs1374805897 1272 dbSNP
rs982324150 1277 dbSNP
rs10030206 1295 dbSNP
rs1275673700 1299 dbSNP
rs1367237725 1305 dbSNP
rs1217687991 1322 dbSNP
rs1418844626 1324 dbSNP
rs1181432912 1338 dbSNP
rs1319714747 1342 dbSNP
rs908803866 1356 dbSNP
rs1029576924 1357 dbSNP
rs1252674345 1358 dbSNP
rs996408095 1375 dbSNP
rs1223055814 1388 dbSNP
rs1246771023 1389 dbSNP
rs984335402 1390 dbSNP
rs1477514154 1401 dbSNP
rs952939959 1407 dbSNP
rs899437173 1409 dbSNP
rs765268483 1413 dbSNP
rs1016194092 1428 dbSNP
rs1398664014 1429 dbSNP
rs1407559567 1434 dbSNP
rs1028362209 1437 dbSNP
rs1272518727 1445 dbSNP
rs1211551295 1448 dbSNP
rs550275961 1451 dbSNP
rs1336757451 1452 dbSNP
rs975806339 1461 dbSNP
rs773766199 1480 dbSNP
rs1342181369 1482 dbSNP
rs965514644 1487 dbSNP
rs1218945036 1488 dbSNP
rs1057251170 1498 dbSNP
rs182573918 1510 dbSNP
rs938512135 1523 dbSNP
rs1237802365 1528 dbSNP
rs1008744028 1534 dbSNP
rs902320033 1543 dbSNP
rs368242130 1550 dbSNP
rs1264798949 1554 dbSNP
rs947297245 1570 dbSNP
rs1193464821 1575 dbSNP
rs1421925796 1576 dbSNP
rs1474083837 1578 dbSNP
rs1394351021 1581 dbSNP
rs145123789 1586 dbSNP
rs1463333839 1587 dbSNP
rs988459393 1588 dbSNP
rs539917181 1589 dbSNP
rs748697417 1595 dbSNP
rs912309993 1599 dbSNP
rs986525292 1600 dbSNP
rs1297426592 1605 dbSNP
rs1324442955 1625 dbSNP
rs376176502 1628 dbSNP
rs115329310 1633 dbSNP
rs1355045211 1636 dbSNP
rs906299817 1640 dbSNP
rs545996213 1658 dbSNP
rs575820405 1668 dbSNP
rs768238016 1671 dbSNP
rs908751535 1688 dbSNP
rs1354051361 1697 dbSNP
rs1215399068 1701 dbSNP
rs775461441 1705 dbSNP
rs1444444284 1706 dbSNP
rs984283210 1706 dbSNP
rs963577925 1718 dbSNP
rs931581938 1724 dbSNP
rs557650193 1725 dbSNP
rs115770495 1726 dbSNP
rs879187137 1728 dbSNP
rs1191728860 1738 dbSNP
rs965731624 1741 dbSNP
rs1019703204 1745 dbSNP
rs1419374930 1747 dbSNP
rs114469340 1751 dbSNP
rs1382546046 1764 dbSNP
rs1002926942 1768 dbSNP
rs905957278 1777 dbSNP
rs1339859449 1780 dbSNP
rs553452752 1791 dbSNP
rs535116458 1794 dbSNP
rs1011441426 1798 dbSNP
rs1204360787 1800 dbSNP
rs1020775717 1807 dbSNP
rs1239007789 1809 dbSNP
rs1262166519 1821 dbSNP
rs1347586611 1826 dbSNP
rs1010679141 1831 dbSNP
rs538105525 1841 dbSNP
rs1441263321 1842 dbSNP
rs1181020943 1845 dbSNP
rs1238887658 1849 dbSNP
rs1439117242 1855 dbSNP
rs1177004028 1863 dbSNP
rs1379526542 1868 dbSNP
rs557935020 1869 dbSNP
rs1466733612 1871 dbSNP
rs934565116 1873 dbSNP
rs539639015 1874 dbSNP
rs188930061 1877 dbSNP
rs550834012 1879 dbSNP
rs529201239 1885 dbSNP
rs1046062948 1893 dbSNP
rs201773725 1912 dbSNP
rs1174076424 1920 dbSNP
rs139955244 1921 dbSNP
rs567714508 1925 dbSNP
rs546230660 1933 dbSNP
rs1434167247 1942 dbSNP
rs183322988 1949 dbSNP
rs921036800 1951 dbSNP
rs974924909 1959 dbSNP
rs1478942172 1961 dbSNP
rs1201105312 1964 dbSNP
rs45510401 1964 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions hESCs (WA-09)
Disease 9429.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in SRR359787. RNA binding protein: AGO2. Condition:4-thiouridine ...

- Lipchina I; Elkabetz Y; Hafner M; Sheridan et al., 2011, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' agAUUGUGGUGUCA---CACCAAAc 5'
            ||:: | :::||   ||||||| 
Target 5' ggUAGUUCAGUGGUUUAGUGGUUU- 3'
5 - 28
Article - Lipchina I; Elkabetz Y; Hafner M; Sheridan et al.
- Genes & development, 2011
MicroRNAs are important regulators in many cellular processes, including stem cell self-renewal. Recent studies demonstrated their function as pluripotency factors with the capacity for somatic cell reprogramming. However, their role in human embryonic stem (ES) cells (hESCs) remains poorly understood, partially due to the lack of genome-wide strategies to identify their targets. Here, we performed comprehensive microRNA profiling in hESCs and in purified neural and mesenchymal derivatives. Using a combination of AGO cross-linking and microRNA perturbation experiments, together with computational prediction, we identified the targets of the miR-302/367 cluster, the most abundant microRNAs in hESCs. Functional studies identified novel roles of miR-302/367 in maintaining pluripotency and regulating hESC differentiation. We show that in addition to its role in TGF-beta signaling, miR-302/367 promotes bone morphogenetic protein (BMP) signaling by targeting BMP inhibitors TOB2, DAZAP2, and SLAIN1. This study broadens our understanding of microRNA function in hESCs and is a valuable resource for future studies in this area.
LinkOut: [PMID: 22012620]
CLIP-seq Support 1 for dataset SRR359787
Method / RBP PAR-CLIP / AGO2
Cell line / Condition hESCs (WA-09) / 4-thiouridine, RNase T1
Location of target site ENST00000515655.1 | 3UTR | UUGGGGUAGUUCAGUGGUUUAGUGGUUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22012620 / SRX103431
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28544 Breast cancer -0.746 1.4e-5 -0.675 1.5e-4 24 Click to see details
GSE42095 Differentiated embryonic stem cells -0.443 1.7e-2 -0.461 1.3e-2 23 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.366 3.6e-2 -0.433 1.5e-2 25 Click to see details
GSE32688 Pancreatic cancer 0.253 8.1e-2 0.306 4.4e-2 32 Click to see details
GSE38226 Liver fibrosis 0.314 8.3e-2 0.308 8.7e-2 21 Click to see details
GSE21687 Ependynoma primary tumors 0.164 9.8e-2 0.193 6.3e-2 64 Click to see details
GSE26953 Aortic valvular endothelial cells -0.253 1.2e-1 -0.311 7.0e-2 24 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.205 1.9e-1 -0.313 9.0e-2 20 Click to see details
GSE17498 Multiple myeloma 0.059 3.6e-1 0.049 3.8e-1 40 Click to see details
GSE28260 Renal cortex and medulla 0.09 3.8e-1 0.298 1.6e-1 13 Click to see details
GSE19350 CNS germ cell tumors 0.027 4.7e-1 0.483 5.6e-2 12 Click to see details
GSE19350 CNS germ cell tumors 0.027 4.7e-1 0.483 5.6e-2 12 Click to see details
GSE19350 CNS germ cell tumors 0.027 4.7e-1 0.483 5.6e-2 12 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
LUSC 0.353 0.03 0.510 0 30 Click to see details
BLCA -0.87 0.07 -0.200 0.4 4 Click to see details
LIHC 0.22 0.12 0.359 0.03 30 Click to see details
STAD -0.197 0.2 -0.221 0.17 21 Click to see details
THCA 0.128 0.2 0.085 0.29 45 Click to see details
KICH -0.223 0.21 -0.111 0.35 15 Click to see details
UCEC 0.213 0.21 0.256 0.17 16 Click to see details
BRCA 0.123 0.22 0.059 0.36 42 Click to see details
ESCA -0.275 0.22 0.067 0.43 10 Click to see details
PAAD -0.484 0.26 -0.200 0.4 4 Click to see details
HNSC -0.153 0.27 0.119 0.32 18 Click to see details
CHOL -0.22 0.34 -0.200 0.35 6 Click to see details
KIRC -0.054 0.37 -0.074 0.32 43 Click to see details
PRAD -0.04 0.4 -0.176 0.12 46 Click to see details
LUAD -0.196 0.4 -0.800 0.1 4 Click to see details
KIRP -0.003 0.49 0.091 0.35 21 Click to see details
KIRP -0.003 0.49 0.091 0.35 21 Click to see details
KIRP -0.003 0.49 0.091 0.35 21 Click to see details
KIRP -0.003 0.49 0.091 0.35 21 Click to see details
95 hsa-miR-497-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT092955 CYP2U1 cytochrome P450 family 2 subfamily U member 1 2 4
MIRT124568 PRRC2B proline rich coiled-coil 2B 2 2
MIRT125196 EIF1AX eukaryotic translation initiation factor 1A, X-linked 2 4
MIRT147296 KPNA2 karyopherin subunit alpha 2 2 8
MIRT163999 KIAA1109 KIAA1109 2 4
MIRT252495 NWD1 NACHT and WD repeat domain containing 1 2 2
MIRT357969 GRPEL2 GrpE like 2, mitochondrial 2 2
MIRT443007 TRIOBP TRIO and F-actin binding protein 2 2
MIRT443524 NETO1 neuropilin and tolloid like 1 2 2
MIRT443573 EVX2 even-skipped homeobox 2 2 2
MIRT443656 BACH1 BTB domain and CNC homolog 1 2 2
MIRT460670 KRT10 keratin 10 2 8
MIRT464761 UBE2N ubiquitin conjugating enzyme E2 N 2 2
MIRT465032 LINC00598 long intergenic non-protein coding RNA 598 2 2
MIRT465040 TTC39C tetratricopeptide repeat domain 39C 2 2
MIRT468667 SEC62 SEC62 homolog, preprotein translocation factor 2 2
MIRT473694 MAPK8 mitogen-activated protein kinase 8 2 4
MIRT477618 EFNA3 ephrin A3 2 2
MIRT480506 C11orf57 chromosome 11 open reading frame 57 2 2
MIRT480592 BUB3 BUB3, mitotic checkpoint protein 2 2
MIRT486915 ZNF398 zinc finger protein 398 2 6
MIRT487770 ANKEF1 ankyrin repeat and EF-hand domain containing 1 2 16
MIRT493265 MDFIC MyoD family inhibitor domain containing 2 2
MIRT495271 SLC1A2 solute carrier family 1 member 2 2 4
MIRT495309 CHST12 carbohydrate sulfotransferase 12 2 2
MIRT496681 DPP6 dipeptidyl peptidase like 6 2 4
MIRT496891 FOXP1 forkhead box P1 2 2
MIRT497330 IRF4 interferon regulatory factor 4 2 2
MIRT498272 KIAA1644 KIAA1644 2 2
MIRT498634 CHD4 chromodomain helicase DNA binding protein 4 2 10
MIRT500581 USP53 ubiquitin specific peptidase 53 2 2
MIRT500751 TMPPE transmembrane protein with metallophosphoesterase domain 2 6
MIRT509668 ZNF354B zinc finger protein 354B 2 10
MIRT510919 PSMA2 proteasome subunit alpha 2 2 4
MIRT519118 CEP76 centrosomal protein 76 2 2
MIRT526193 ABCG2 ATP binding cassette subfamily G member 2 (Junior blood group) 2 2
MIRT526746 HLA-DOB major histocompatibility complex, class II, DO beta 2 2
MIRT527270 FBLN2 fibulin 2 2 2
MIRT528198 PLEKHM2 pleckstrin homology and RUN domain containing M2 2 2
MIRT528330 TBC1D22B TBC1 domain family member 22B 2 2
MIRT530346 GABRB3 gamma-aminobutyric acid type A receptor beta3 subunit 2 2
MIRT533627 TMX3 thioredoxin related transmembrane protein 3 2 2
MIRT533738 TMEM200C transmembrane protein 200C 2 2
MIRT533779 TMEM133 transmembrane protein 133 2 2
MIRT534317 SKIDA1 SKI/DACH domain containing 1 2 2
MIRT538438 COG5 component of oligomeric golgi complex 5 2 2
MIRT539156 AREL1 apoptosis resistant E3 ubiquitin protein ligase 1 2 2
MIRT539474 ADARB2 adenosine deaminase, RNA specific B2 (inactive) 2 2
MIRT539620 SHISA9 shisa family member 9 2 2
MIRT539650 BUB1 BUB1 mitotic checkpoint serine/threonine kinase 2 2
MIRT540346 OPHN1 oligophrenin 1 2 2
MIRT540412 PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 2 2
MIRT541200 HSP90AA1 heat shock protein 90 alpha family class A member 1 2 2
MIRT541395 CDC27 cell division cycle 27 2 2
MIRT546443 SNX5 sorting nexin 5 2 2
MIRT547369 MSI2 musashi RNA binding protein 2 2 2
MIRT553288 TSPAN3 tetraspanin 3 2 2
MIRT554402 SERP1 stress associated endoplasmic reticulum protein 1 2 2
MIRT557822 FOXN2 forkhead box N2 2 2
MIRT568530 ANP32E acidic nuclear phosphoprotein 32 family member E 2 2
MIRT569508 THYN1 thymocyte nuclear protein 1 2 2
MIRT570707 FAM69A family with sequence similarity 69 member A 2 2
MIRT608376 PIWIL2 piwi like RNA-mediated gene silencing 2 2 2
MIRT608483 NKTR natural killer cell triggering receptor 2 6
MIRT613533 TRA2B transformer 2 beta homolog 2 2
MIRT616601 ELP2 elongator acetyltransferase complex subunit 2 2 2
MIRT618166 DUSP18 dual specificity phosphatase 18 2 2
MIRT632059 CEP135 centrosomal protein 135 2 2
MIRT647379 ZDHHC23 zinc finger DHHC-type containing 23 2 2
MIRT648366 POTED POTE ankyrin domain family member D 2 2
MIRT651075 ZNF518B zinc finger protein 518B 2 4
MIRT653618 SLC30A4 solute carrier family 30 member 4 2 2
MIRT653636 SLC30A1 solute carrier family 30 member 1 2 2
MIRT654895 POU2F1 POU class 2 homeobox 1 2 2
MIRT656232 MFSD6 major facilitator superfamily domain containing 6 2 2
MIRT659880 CAPRIN1 cell cycle associated protein 1 2 2
MIRT660526 ARL4C ADP ribosylation factor like GTPase 4C 2 2
MIRT666286 SLC30A3 solute carrier family 30 member 3 2 2
MIRT686808 SNX2 sorting nexin 2 2 4
MIRT695302 TK1 thymidine kinase 1 2 2
MIRT699737 SERINC3 serine incorporator 3 2 2
MIRT700794 PIAS2 protein inhibitor of activated STAT 2 2 2
MIRT712270 PPP1CB protein phosphatase 1 catalytic subunit beta 2 2
MIRT712617 KNSTRN kinetochore localized astrin/SPAG5 binding protein 2 2
MIRT714264 RPL10A ribosomal protein L10a 2 2
MIRT715072 TMTC1 transmembrane and tetratricopeptide repeat containing 1 2 2
MIRT715386 TADA3 transcriptional adaptor 3 2 2
MIRT716397 NPAS1 neuronal PAS domain protein 1 2 2
MIRT725328 NFASC neurofascin 2 2
MIRT725503 GANAB glucosidase II alpha subunit 2 2
MIRT732913 IRAK2 interleukin 1 receptor associated kinase 2 3 0
MIRT734890 SMAD3 SMAD family member 3 3 0
MIRT737328 LINC02476 long intergenic non-protein coding RNA 2476 3 0
MIRT737544 MALAT1 metastasis associated lung adenocarcinoma transcript 1 (non-protein coding) 4 0
MIRT755545 PAK1 p21 (RAC1) activated kinase 1 3 1
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-497 Bufalin NULL 9547215 Quantitative real-time PCR colorectal cancer HCT116 cells 24375248 2014 up-regulated
miR-497 Diethylstilbestrol approved 448537 Microarray mammosphere-derived epithelial cells (MDEC) 19549897 2009 up-regulated
miR-497 Ethanol NULL 702 Quantitative real-time PCR CIE10 22141737 2012 up-regulated
miR-497 Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) NULL 8490 Microarray mouse brain 19270793 2009 up-regulated
miR-497 Reversine NULL 210332 Microarray C2C12 myoblast cells 24513286 2014 down-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-497 Tamoxifen 2733525 NSC180973 approved sensitive Low Breast Cancer cell line (MCF-7, T47D)
hsa-mir-497 Dabrafenib 44462760 NSC764134 approved sensitive cell line (A375)
hsa-mir-497 Paclitaxel 36314 NSC125973 approved resistant cell line (W1)
hsa-mir-497 Cisplatin 5460033 NSC119875 approved resistant cell line (CIS)
hsa-mir-497 Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-mir-497 Androstenedione+Letrozole sensitive cell line (MCF-7)
hsa-mir-497 Tamoxifen 2733525 NSC180973 approved sensitive cell line (MCF7)
hsa-mir-497 Cisplatin 5460033 NSC119875 approved sensitive cell line (BxPC3)
hsa-miR-497-3p Mitoxantrone 4212 NSC279836 approved sensitive High Breast Cancer cell line (BT-20, BT-474, BT-549, CAMA-1, HCC1143, HCC1395, HCC1569, HCC1806, HCC-1937, HCC1954, HCC202, HCC38, HCC70, Hs578T, MCF-7, MDA-MB-175VII, MDA-MB-231, MDA-MB-361, MDA-MB-415, MDA-MB-436, MDA-MB-468, SKBR3, T47D, UACC812, EVSA-T, MPE-600 , SK-BR-
hsa-miR-497-3p Docetaxel 148124 NSC628503 approved resistant High Breast Cancer cell line (MDA-MB-231, MCF-7)
hsa-miR-497-3p Cisplatin 5460033 NSC119875 approved resistant High Non-Small Cell Lung Cancer cell line (A549, PC-9)
hsa-miR-497-3p Cisplatin 5460033 NSC119875 approved resistant Low Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-497-3p Gefitinib 123631 NSC715055 approved sensitive cell line (PC9)
hsa-miR-497-3p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-497-3p Cisplatin 5460033 NSC119875 approved resistant tissue
hsa-miR-497-3p Sunitinib 5329102 NSC750690 approved resistant tissue (CardB)
hsa-miR-497-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-497-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)

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