miRTarBase - #MIRT527175


—
pre-miRNA Information
pre-miRNA hsa-mir-6868   
Genomic Coordinates chr17: 76098019 - 76098076
Description Homo sapiens miR-6868 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6868-3p
Sequence 38| UUCCUUCUGUUGUCUGUGCAG |58
Evidence Experimental
Experiments Meta-analysis
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSM4415890 16 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1268215934 1 dbSNP
rs199573454 9 dbSNP
rs893365109 12 dbSNP
rs370367037 13 dbSNP
rs7208391 16 dbSNP
rs752026363 19 dbSNP
rs113525369 20 dbSNP
Putative Targets

Gene Information
Gene Symbol LRRTM4   
Synonyms -
Description leucine rich repeat transmembrane neuronal 4
Transcript NM_024993   
Other Transcripts NM_001134745   
Expression
Putative miRNA Targets on LRRTM4
3'UTR of LRRTM4
(miRNA target sites are highlighted)		 
>LRRTM4|NM_024993|3'UTR
   1 ACCATGATCCTCCTAAAAGCATTTCTACTGCGGGGAAGGAGAGGTAAATGTTTGAAGCCCTAGAGGTGTCTCTAATCACT
  81 AGAAAGATTAATGACCCTTTTGCTTTTGGGTTTTGCTCAGTGTGAAAGGTTACTTAATTAAATTACAACCACCAGGAAAT
 161 TGACTGCTTTTTTTTTTTTTTTAAATGGTTGAAACTTGAAGGAAGTTCATTCAAGGATAAGTTGGAATAAAGCACTATGT
 241 TAAAACATCTGCTTTTTAACAATTTGTATACAGGGGTTGGACTTAAAAACACACATACAAACAAAACTCTTTTCATTCTG
 321 AAATTTCTGTCTGGTTCTTGGTGTTTGACTGTTGTAATGGAGTAAAGAAGAGGGCCAGCTTAATTTAAAAATAAAGTGAG
 401 TTTACCAAAATTCCAGAAGGTAATGAAGATTTAAACCAAAGAGCAATTTTCCCAAGGGTTGATTTTGTTGTAAATTTTTA
 481 GTTTTAATGAAAGCATGCAACAGGGATCTCACACCCATGTTACTTGCCATTTAGTTATTATACCAGCATAGAGAATGTCA
 561 GAGGCCTACTGTGTAATTGTATCAGGCTCCTAAGGCTTCTTTCTTTTTTTTTTTTTGTTTCCTTCTTTCCTACTTTCTTT
 641 CACTCCTTCCTTTCCTTCCTTTCTCTTCCTTCTTTTTTTGTTTGTTTGTTTGTTTTTTAATTACTGGGATATAGATCCGA
 721 TTTCAAAGGTTTTTATGCACTGGCTATTTGTGTTTAATCAGAATGAAACTTCAATTCCATGCTTTGGCTTTGTCCCTGGT
 801 AACTAAAATCAGGTCACAATTTTGTGGATGATTTAGCAATAATAAAATGGCAGTCATAACAGGGACTGTTTGTCAGTATT
 881 GCTGTCATCCCCAAAAGAAATGATATGTATTCTTGTTAAACTTATTAAAAAATAAGTGATACAAATATTTATAAATAAAA
 961 GGAGAGAGGTTTGAGTTCTGGGTATCCTCCCTTTCTGTAACAGCCTCAAATAAAGGTGTACCTTCCATGTTATATTATTT
1041 TTGTTTTTATAAGAATAAATTTGGACCCGGTTTCTGATTATTTAATTTAAAAGATCACTTACAGGATCATGTTAGTGAGC
1121 AGACAAATAGTCACAAATTTCAAACTTGTCAATAAGTAATGCTGGATGTAAATTGTTCTTTTCTTGGTAATGTTGATCAT
1201 TATGTGCAAAGACTGACTACTAAGGCCTTGTTGCTGGAAGAAACTAGTGAAGAGAGGTTAAATTCTGGCAATATAATGTT
1281 TTAGTATCTGATTTTAGATGATCACTCTTTCAAAAGACAGTTTTAATGAGTAATTAAAGATGTTGCCCTTTCTAATGCTA
1361 GTTAACAGTTGGAAAATATAATTGCTCTTTGATAGCATATACTCCAATTTTTCCATAGTCCTAACTACAAATGCTAATGA
1441 AAATGTTTTCAGACAAAGCACTGAATTTGAAATAATCTCTAACTCAGTACAATTTGGACTATTGAACTGTTCTTCAAAGA
1521 ATTCATTTTCTTCTTTTTTGTGTATCATTGAAAATAAGAGAAGTAATCCCAGATAATAAATTCCTAAAAGGAAACTGTAT
1601 AAGCAATTGCCCTTAAAAATTAAAAAGAATAAAAGATTTTCTATAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' gacGUGUCUGUUGUCUUCCuu 5'
             || | |:  |||||||  
Target 5' tacCA-AAATTCCAGAAGGta 3'
 403 - 422 129.00 -9.50
2 
miRNA  3' gacGUGUCUGUUGUCUUCCUu 5'
             :|| | |:: :|||||| 
Target 5' ttcTACTG-CGG-GGAAGGAg 3'
 23 - 41 128.00 -14.50
3 
miRNA  3' gacgugUCUGUUGUCUUCCUu 5'
                | |:|| ||||| | 
Target 5' cattgaAAATAAGAGAAGTAa 3'
 1546 - 1566 123.00 -6.90
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31524797 6 COSMIC
COSN30192491 10 COSMIC
COSN31511533 30 COSMIC
COSN31582476 31 COSMIC
COSN31505885 33 COSMIC
COSN25384967 46 COSMIC
COSN31581927 51 COSMIC
COSN31520348 57 COSMIC
COSN31507783 59 COSMIC
COSN19702775 68 COSMIC
COSN8609610 80 COSMIC
COSN30537675 85 COSMIC
COSN31585397 132 COSMIC
COSN27231727 167 COSMIC
COSN1242772 168 COSMIC
COSN20096892 168 COSMIC
COSN31588213 180 COSMIC
COSN31487872 182 COSMIC
COSN29217256 252 COSMIC
COSN8561360 276 COSMIC
COSN6684661 283 COSMIC
COSN31555935 284 COSMIC
COSN31537718 327 COSMIC
COSN7084876 338 COSMIC
COSN24299400 374 COSMIC
COSN31548536 390 COSMIC
COSN30176361 441 COSMIC
COSN24987302 461 COSMIC
COSN7993586 466 COSMIC
COSN31570107 481 COSMIC
COSN5957596 583 COSMIC
COSN20096889 603 COSMIC
COSN19656451 604 COSMIC
COSN24299399 630 COSMIC
COSN30539761 632 COSMIC
COSN30539794 633 COSMIC
COSN31514001 637 COSMIC
COSN24971921 669 COSMIC
COSN30051890 836 COSMIC
COSN5957595 903 COSMIC
COSN18723449 922 COSMIC
COSN25669083 936 COSMIC
COSN5957594 957 COSMIC
COSN7993585 1029 COSMIC
COSN23323477 1132 COSMIC
COSN1855787 1274 COSMIC
COSN7084875 1603 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1407845218 3 dbSNP
rs953317342 4 dbSNP
rs778462487 7 dbSNP
rs768089547 9 dbSNP
rs1348118685 16 dbSNP
rs1161113140 18 dbSNP
rs1419462804 19 dbSNP
rs749810384 20 dbSNP
rs780564063 27 dbSNP
rs1481239283 29 dbSNP
rs1269130652 30 dbSNP
rs369806444 31 dbSNP
rs750842196 32 dbSNP
rs1392746635 36 dbSNP
rs1012291921 38 dbSNP
rs1263023719 42 dbSNP
rs781392498 49 dbSNP
rs1217060636 50 dbSNP
rs1265503195 51 dbSNP
rs1189842186 55 dbSNP
rs1253181208 58 dbSNP
rs1473111307 59 dbSNP
rs1181063152 60 dbSNP
rs1409262362 62 dbSNP
rs1462585731 66 dbSNP
rs796980662 68 dbSNP
rs533626980 92 dbSNP
rs1035063807 95 dbSNP
rs554632483 96 dbSNP
rs745743302 105 dbSNP
rs1349233006 107 dbSNP
rs994470500 109 dbSNP
rs1456387733 115 dbSNP
rs897098354 117 dbSNP
rs1277413683 121 dbSNP
rs1408955814 122 dbSNP
rs1038705952 125 dbSNP
rs1005365639 128 dbSNP
rs898109277 129 dbSNP
rs1230112942 131 dbSNP
rs534936976 135 dbSNP
rs1043565764 151 dbSNP
rs1321186740 163 dbSNP
rs889625759 165 dbSNP
rs1049472555 169 dbSNP
rs1277359463 171 dbSNP
rs1364963332 172 dbSNP
rs1483604440 177 dbSNP
rs1204829349 179 dbSNP
rs1249187116 180 dbSNP
rs1006372922 181 dbSNP
rs11684820 182 dbSNP
rs1412514585 183 dbSNP
rs1428895791 183 dbSNP
rs200627311 183 dbSNP
rs201250778 183 dbSNP
rs36044249 183 dbSNP
rs879245456 183 dbSNP
rs933764113 183 dbSNP
rs1368642649 184 dbSNP
rs62159488 185 dbSNP
rs1368952367 186 dbSNP
rs201541858 186 dbSNP
rs1403182852 187 dbSNP
rs1363572231 188 dbSNP
rs182549423 189 dbSNP
rs1430379787 191 dbSNP
rs1372268705 192 dbSNP
rs894134165 199 dbSNP
rs1052812135 219 dbSNP
rs558421139 221 dbSNP
rs924190021 226 dbSNP
rs1197996439 227 dbSNP
rs1489651313 229 dbSNP
rs1236500170 236 dbSNP
rs980111715 237 dbSNP
rs1254542754 243 dbSNP
rs1189882643 247 dbSNP
rs1390725192 248 dbSNP
rs538493879 250 dbSNP
rs1342135301 257 dbSNP
rs924553278 259 dbSNP
rs569465123 264 dbSNP
rs947181984 267 dbSNP
rs770962777 268 dbSNP
rs1322562822 273 dbSNP
rs1235971123 275 dbSNP
rs960798479 278 dbSNP
rs1312921747 280 dbSNP
rs1300859084 292 dbSNP
rs1403125484 298 dbSNP
rs191465072 304 dbSNP
rs1352384371 307 dbSNP
rs1035417318 309 dbSNP
rs994153027 311 dbSNP
rs1220134475 314 dbSNP
rs961694058 329 dbSNP
rs1210061073 334 dbSNP
rs1248178490 341 dbSNP
rs1016811987 352 dbSNP
rs1186642213 353 dbSNP
rs923292341 369 dbSNP
rs1005479866 374 dbSNP
rs1478247128 375 dbSNP
rs889617402 380 dbSNP
rs1410349094 391 dbSNP
rs1395773123 393 dbSNP
rs976511445 396 dbSNP
rs1161636200 398 dbSNP
rs1296172636 399 dbSNP
rs1049629921 407 dbSNP
rs1319164452 411 dbSNP
rs1015562804 425 dbSNP
rs997917391 443 dbSNP
rs1467404615 446 dbSNP
rs1274561216 455 dbSNP
rs1365921561 458 dbSNP
rs900951181 459 dbSNP
rs535934450 462 dbSNP
rs1268338020 466 dbSNP
rs934321807 469 dbSNP
rs1206229047 480 dbSNP
rs1291955225 486 dbSNP
rs1371637304 488 dbSNP
rs1198077598 493 dbSNP
rs1244825676 495 dbSNP
rs1023792980 498 dbSNP
rs140302440 503 dbSNP
rs866193702 508 dbSNP
rs1175304616 509 dbSNP
rs1043973364 510 dbSNP
rs1412919798 513 dbSNP
rs1456795719 515 dbSNP
rs764739146 517 dbSNP
rs894240939 523 dbSNP
rs916726851 523 dbSNP
rs990975349 529 dbSNP
rs747293259 541 dbSNP
rs1182341887 548 dbSNP
rs547106864 549 dbSNP
rs1226044892 559 dbSNP
rs960872854 563 dbSNP
rs928047430 568 dbSNP
rs973229612 579 dbSNP
rs961367160 581 dbSNP
rs1209219514 583 dbSNP
rs1017384065 586 dbSNP
rs777955298 590 dbSNP
rs953967865 591 dbSNP
rs1252825610 596 dbSNP
rs1255817458 599 dbSNP
rs1041619291 603 dbSNP
rs1449341237 603 dbSNP
rs1028147928 604 dbSNP
rs397812357 604 dbSNP
rs914397819 605 dbSNP
rs1221893124 606 dbSNP
rs1432032003 607 dbSNP
rs997992714 607 dbSNP
rs1289067075 608 dbSNP
rs1370336904 615 dbSNP
rs1491075943 617 dbSNP
rs376357631 617 dbSNP
rs5832288 617 dbSNP
rs5832289 617 dbSNP
rs77365108 617 dbSNP
rs878994212 617 dbSNP
rs779093236 618 dbSNP
rs79425265 618 dbSNP
rs1330799368 621 dbSNP
rs770215772 621 dbSNP
rs527264206 622 dbSNP
rs1335039144 623 dbSNP
rs560127871 626 dbSNP
rs1443099797 636 dbSNP
rs560063254 640 dbSNP
rs1397520023 642 dbSNP
rs1402605533 644 dbSNP
rs144927650 651 dbSNP
rs1467889345 653 dbSNP
rs1390467241 658 dbSNP
rs904184868 663 dbSNP
rs1159169176 664 dbSNP
rs923378760 666 dbSNP
rs1402410082 672 dbSNP
rs1394959224 675 dbSNP
rs1042725986 676 dbSNP
rs946954772 680 dbSNP
rs976204702 680 dbSNP
rs1296750516 681 dbSNP
rs1190256884 684 dbSNP
rs1424954182 688 dbSNP
rs1257999513 692 dbSNP
rs1345898076 694 dbSNP
rs1241427704 696 dbSNP
rs962330066 696 dbSNP
rs1466294387 703 dbSNP
rs895371619 704 dbSNP
rs761393903 709 dbSNP
rs758555394 712 dbSNP
rs565961054 718 dbSNP
rs186604248 719 dbSNP
rs1427128731 739 dbSNP
rs985000856 751 dbSNP
rs952337993 755 dbSNP
rs1465290082 760 dbSNP
rs1173797441 774 dbSNP
rs1466371276 785 dbSNP
rs1457281072 790 dbSNP
rs1319844337 793 dbSNP
rs182282675 799 dbSNP
rs1359708712 813 dbSNP
rs1388303700 818 dbSNP
rs1301801983 825 dbSNP
rs1269024955 830 dbSNP
rs1223186128 849 dbSNP
rs939496176 850 dbSNP
rs1261469094 854 dbSNP
rs1331357538 872 dbSNP
rs74933570 873 dbSNP
rs748553990 887 dbSNP
rs940141559 895 dbSNP
rs1485139364 903 dbSNP
rs1012859538 904 dbSNP
rs909866854 910 dbSNP
rs984150291 929 dbSNP
rs1267345256 940 dbSNP
rs960920146 942 dbSNP
rs1432944329 943 dbSNP
rs1196885061 961 dbSNP
rs1413660255 969 dbSNP
rs1472641622 974 dbSNP
rs1470317837 980 dbSNP
rs1342921232 981 dbSNP
rs1459434264 982 dbSNP
rs1035826460 984 dbSNP
rs954040163 995 dbSNP
rs200307251 1000 dbSNP
rs1028223015 1004 dbSNP
rs1002630618 1006 dbSNP
rs976669656 1008 dbSNP
rs1341050678 1022 dbSNP
rs965209773 1027 dbSNP
rs1314102130 1033 dbSNP
rs764222442 1043 dbSNP
rs1366841580 1049 dbSNP
rs1019993071 1063 dbSNP
rs187138886 1068 dbSNP
rs779109083 1069 dbSNP
rs1220656829 1085 dbSNP
rs1164558012 1087 dbSNP
rs1253531558 1089 dbSNP
rs1050237546 1094 dbSNP
rs931777482 1096 dbSNP
rs115464868 1104 dbSNP
rs561410216 1132 dbSNP
rs1021340245 1144 dbSNP
rs1040820580 1146 dbSNP
rs1182070904 1152 dbSNP
rs754281171 1154 dbSNP
rs764113597 1156 dbSNP
rs1422531864 1173 dbSNP
rs78491533 1178 dbSNP
rs907878969 1179 dbSNP
rs1248836930 1192 dbSNP
rs1297797268 1199 dbSNP
rs1055269942 1207 dbSNP
rs1371326709 1208 dbSNP
rs1192707597 1212 dbSNP
rs572106176 1217 dbSNP
rs939632839 1220 dbSNP
rs1314095415 1222 dbSNP
rs1445544783 1234 dbSNP
rs1359269167 1236 dbSNP
rs1244419049 1237 dbSNP
rs906699241 1245 dbSNP
rs149909362 1253 dbSNP
rs139344869 1254 dbSNP
rs529557131 1271 dbSNP
rs1483962479 1274 dbSNP
rs909940754 1278 dbSNP
rs1181881815 1287 dbSNP
rs575848073 1294 dbSNP
rs1442775469 1298 dbSNP
rs991103541 1302 dbSNP
rs1428831502 1303 dbSNP
rs961119266 1310 dbSNP
rs1035200984 1331 dbSNP
rs545293334 1339 dbSNP
rs1290959549 1352 dbSNP
rs183780641 1353 dbSNP
rs984225647 1354 dbSNP
rs932600820 1360 dbSNP
rs1451162031 1365 dbSNP
rs1344078062 1366 dbSNP
rs1270588637 1368 dbSNP
rs191478993 1379 dbSNP
rs1324397141 1391 dbSNP
rs976659858 1393 dbSNP
rs1386858545 1397 dbSNP
rs1365454557 1412 dbSNP
rs1011277477 1418 dbSNP
rs965695817 1421 dbSNP
rs1162257708 1424 dbSNP
rs1313520994 1429 dbSNP
rs567286980 1434 dbSNP
rs1210378379 1439 dbSNP
rs1242047727 1447 dbSNP
rs924453392 1454 dbSNP
rs547456950 1458 dbSNP
rs533815897 1479 dbSNP
rs892820950 1480 dbSNP
rs1223120139 1486 dbSNP
rs1184498936 1487 dbSNP
rs562002333 1499 dbSNP
rs1028891930 1502 dbSNP
rs996111015 1509 dbSNP
rs1177033038 1511 dbSNP
rs751317512 1516 dbSNP
rs1021289457 1519 dbSNP
rs1391145669 1522 dbSNP
rs1323167639 1524 dbSNP
rs1167757284 1531 dbSNP
rs901639944 1532 dbSNP
rs1430471683 1536 dbSNP
rs1474546133 1544 dbSNP
rs1268853570 1545 dbSNP
rs1248674888 1548 dbSNP
rs1370158173 1551 dbSNP
rs1040246229 1555 dbSNP
rs1199595998 1557 dbSNP
rs1320840001 1561 dbSNP
rs1490212865 1564 dbSNP
rs940752809 1564 dbSNP
rs1446287330 1570 dbSNP
rs1012626448 1571 dbSNP
rs886553446 1592 dbSNP
rs185545008 1599 dbSNP
rs181059905 1608 dbSNP
rs1484030889 1614 dbSNP
rs1428802532 1622 dbSNP
rs150872381 1635 dbSNP
rs916581456 1641 dbSNP
rs563927008 1645 dbSNP
rs142181461 1649 dbSNP
rs1352022059 1655 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions hESCs (WA-09)
Disease 80059.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in SRR359787. RNA binding protein: AGO2. Condition:4-thiouridine ...

- Lipchina I; Elkabetz Y; Hafner M; Sheridan et al., 2011, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' gacgugucuguuguCUUCCUu 5'
                        |||||| 
Target 5' --ugguugaaacuuGAAGGAa 3'
 		1 - 19
Article - Lipchina I; Elkabetz Y; Hafner M; Sheridan et al.
- Genes & development, 2011
MicroRNAs are important regulators in many cellular processes, including stem cell self-renewal. Recent studies demonstrated their function as pluripotency factors with the capacity for somatic cell reprogramming. However, their role in human embryonic stem (ES) cells (hESCs) remains poorly understood, partially due to the lack of genome-wide strategies to identify their targets. Here, we performed comprehensive microRNA profiling in hESCs and in purified neural and mesenchymal derivatives. Using a combination of AGO cross-linking and microRNA perturbation experiments, together with computational prediction, we identified the targets of the miR-302/367 cluster, the most abundant microRNAs in hESCs. Functional studies identified novel roles of miR-302/367 in maintaining pluripotency and regulating hESC differentiation. We show that in addition to its role in TGF-beta signaling, miR-302/367 promotes bone morphogenetic protein (BMP) signaling by targeting BMP inhibitors TOB2, DAZAP2, and SLAIN1. This study broadens our understanding of microRNA function in hESCs and is a valuable resource for future studies in this area.
LinkOut: [PMID: 22012620]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions Prostate Tissue
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in SRX1760632. RNA binding protein: AGO2. Condition:AGO-CLIP-22RV1_C ...

- Hamilton MP; Rajapakshe KI; Bader DA; Cerne et al., 2016, Neoplasia (New York, N.Y.).

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' gacgugucuguuguCUUCCUu 5'
                        |||||| 
Target 5' ----guugaaacuuGAAGGA- 3'
 		1 - 16
Article - Hamilton MP; Rajapakshe KI; Bader DA; Cerne et al.
- Neoplasia (New York, N.Y.), 2016
MicroRNA (miRNA) deregulation in prostate cancer (PCa) contributes to PCa initiation and metastatic progression. To comprehensively define the cancer-associated changes in miRNA targeting and function in commonly studied models of PCa, we performed photoactivatable ribonucleoside-enhanced cross-linking immunoprecipitation of the Argonaute protein in a panel of PCa cell lines modeling different stages of PCa progression. Using this comprehensive catalogue of miRNA targets, we analyzed miRNA targeting on known drivers of PCa and examined tissue-specific and stage-specific pathway targeting by miRNAs. We found that androgen receptor is the most frequently targeted PCa oncogene and that miR-148a targets the largest number of known PCa drivers. Globally, tissue-specific and stage-specific changes in miRNA targeting are driven by homeostatic response to active oncogenic pathways. Our findings indicate that, even in advanced PCa, the miRNA pool adapts to regulate continuing alterations in the cancer genome to balance oncogenic molecular changes. These findings are important because they are the first to globally characterize miRNA changes in PCa and demonstrate how the miRNA target spectrum responds to staged tumorigenesis.
LinkOut: [PMID: 27292025]
CLIP-seq Support 1 for dataset SRR359787
Method / RBP PAR-CLIP / AGO2
Cell line / Condition hESCs (WA-09) / 4-thiouridine, RNase T1
Location of target site ENST00000409088.3 | 3UTR | UGGUUGAAACUUGAAGGAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22012620 / SRX103431
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
178 hsa-miR-6868-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT107800 SLC1A1 solute carrier family 1 member 1 2 2
MIRT164443 CPEB2 cytoplasmic polyadenylation element binding protein 2 2 2
MIRT180168 NOTCH2 notch 2 2 2
MIRT363961 IMPAD1 inositol monophosphatase domain containing 1 2 2
MIRT445561 POFUT1 protein O-fucosyltransferase 1 2 2
MIRT468817 RSRC2 arginine and serine rich coiled-coil 2 2 4
MIRT475452 HSPA8 heat shock protein family A (Hsp70) member 8 2 6
MIRT478206 DDX6 DEAD-box helicase 6 2 2
MIRT506235 PEX13 peroxisomal biogenesis factor 13 2 4
MIRT507651 CREBRF CREB3 regulatory factor 2 4
MIRT509448 CAPRIN1 cell cycle associated protein 1 2 4
MIRT520196 WASL Wiskott-Aldrich syndrome like 2 2
MIRT521020 SLC38A1 solute carrier family 38 member 1 2 4
MIRT526334 SH3TC2 SH3 domain and tetratricopeptide repeats 2 2 2
MIRT527175 LRRTM4 leucine rich repeat transmembrane neuronal 4 2 2
MIRT527348 FAM69C family with sequence similarity 69 member C 2 2
MIRT527514 FOXB1 forkhead box B1 2 4
MIRT527955 MTAP methylthioadenosine phosphorylase 2 2
MIRT528474 STAMBPL1 STAM binding protein like 1 2 2
MIRT528929 SFMBT2 Scm like with four mbt domains 2 2 2
MIRT531496 NONO non-POU domain containing octamer binding 2 2
MIRT531608 ACP1 acid phosphatase 1, soluble 2 2
MIRT535579 NUP35 nucleoporin 35 2 2
MIRT536158 MAP3K9 mitogen-activated protein kinase kinase kinase 9 2 6
MIRT536194 MAML2 mastermind like transcriptional coactivator 2 2 2
MIRT549649 RSL1D1 ribosomal L1 domain containing 1 2 2
MIRT551819 TMEM138 transmembrane protein 138 2 2
MIRT557174 HOXA11 homeobox A11 2 2
MIRT558889 CCND2 cyclin D2 2 2
MIRT559109 C16orf52 chromosome 16 open reading frame 52 2 2
MIRT569341 EFHC1 EF-hand domain containing 1 2 2
MIRT608169 ERBB2 erb-b2 receptor tyrosine kinase 2 2 2
MIRT609642 PACS2 phosphofurin acidic cluster sorting protein 2 2 2
MIRT610274 PLCXD3 phosphatidylinositol specific phospholipase C X domain containing 3 2 2
MIRT611130 CTBP2 C-terminal binding protein 2 2 2
MIRT611350 KIAA2018 upstream transcription factor family member 3 2 2
MIRT612894 HMGB1 high mobility group box 1 2 2
MIRT613291 BACE2 beta-site APP-cleaving enzyme 2 2 4
MIRT614162 MYO1F myosin IF 2 2
MIRT614217 TSKU tsukushi, small leucine rich proteoglycan 2 2
MIRT615474 RPS6KA3 ribosomal protein S6 kinase A3 2 2
MIRT615863 HSPA6 heat shock protein family A (Hsp70) member 6 2 2
MIRT616022 PRRG4 proline rich and Gla domain 4 2 2
MIRT616349 RASGEF1B RasGEF domain family member 1B 2 2
MIRT616679 FJX1 four jointed box 1 2 2
MIRT616811 PAPPA-AS1 PAPPA antisense RNA 1 2 2
MIRT616964 LMX1A LIM homeobox transcription factor 1 alpha 2 2
MIRT617067 SPIB Spi-B transcription factor 2 2
MIRT618597 C2orf48 chromosome 2 open reading frame 48 2 2
MIRT618656 ATP6AP1L ATPase H+ transporting accessory protein 1 like 2 2
MIRT618914 KLHL4 kelch like family member 4 2 2
MIRT620197 VN1R1 vomeronasal 1 receptor 1 2 2
MIRT620644 CXCL5 C-X-C motif chemokine ligand 5 2 2
MIRT620762 CCR5 C-C motif chemokine receptor 5 (gene/pseudogene) 2 2
MIRT621142 RNF122 ring finger protein 122 2 2
MIRT621248 QTRT1 queuine tRNA-ribosyltransferase catalytic subunit 1 2 2
MIRT622711 PLEKHA2 pleckstrin homology domain containing A2 2 2
MIRT622941 PABPN1 poly(A) binding protein nuclear 1 2 2
MIRT623329 MAK16 MAK16 homolog 2 2
MIRT623539 KCNJ6 potassium voltage-gated channel subfamily J member 6 2 2
MIRT624413 CCDC149 coiled-coil domain containing 149 2 2
MIRT624478 CACNG8 calcium voltage-gated channel auxiliary subunit gamma 8 2 2
MIRT624574 BCL9L B-cell CLL/lymphoma 9 like 2 2
MIRT624584 BCL2L2-PABPN1 BCL2L2-PABPN1 readthrough 2 2
MIRT624685 AR androgen receptor 2 2
MIRT625750 GPC5 glypican 5 2 2
MIRT626539 EMCN endomucin 2 2
MIRT627474 STRN striatin 2 2
MIRT628183 GLP1R glucagon like peptide 1 receptor 2 2
MIRT634165 XKR4 XK related 4 2 2
MIRT634553 LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 2 2
MIRT637463 DEFB105B defensin beta 105B 2 4
MIRT637495 DEFB105A defensin beta 105A 2 4
MIRT638102 ZBTB7A zinc finger and BTB domain containing 7A 2 2
MIRT638313 RNF157 ring finger protein 157 2 2
MIRT639297 OPTN optineurin 2 2
MIRT639588 RGS5 regulator of G protein signaling 5 2 2
MIRT639721 RAB17 RAB17, member RAS oncogene family 2 2
MIRT640060 KPNA6 karyopherin subunit alpha 6 2 2
MIRT640117 DCAF7 DDB1 and CUL4 associated factor 7 2 2
MIRT640387 ZNF785 zinc finger protein 785 2 2
MIRT640579 MYO5A myosin VA 2 2
MIRT640591 TM9SF4 transmembrane 9 superfamily member 4 2 2
MIRT640627 ZFP30 ZFP30 zinc finger protein 2 2
MIRT640761 GLO1 glyoxalase I 2 2
MIRT640808 ZMAT1 zinc finger matrin-type 1 2 2
MIRT641827 TRIM71 tripartite motif containing 71 2 2
MIRT643955 GALNT13 polypeptide N-acetylgalactosaminyltransferase 13 2 2
MIRT644218 ADD1 adducin 1 2 2
MIRT644356 NDUFAF6 NADH:ubiquinone oxidoreductase complex assembly factor 6 2 2
MIRT644560 SPOP speckle type BTB/POZ protein 2 2
MIRT645486 TRIM63 tripartite motif containing 63 2 2
MIRT645595 MRPS15 mitochondrial ribosomal protein S15 2 2
MIRT645840 BRS3 bombesin receptor subtype 3 2 2
MIRT645944 TTF2 transcription termination factor 2 2 2
MIRT646154 VASH2 vasohibin 2 2 2
MIRT648097 LRRFIP1 LRR binding FLII interacting protein 1 2 2
MIRT648131 JAGN1 jagunal homolog 1 2 2
MIRT648469 TCERG1 transcription elongation regulator 1 2 2
MIRT648954 ZNF385D zinc finger protein 385D 2 4
MIRT649447 ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 2 2
MIRT649559 POLD3 DNA polymerase delta 3, accessory subunit 2 2
MIRT649641 SAMHD1 SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 2 2
MIRT650541 MSANTD2 Myb/SANT DNA binding domain containing 2 2 2
MIRT651104 ZNF48 zinc finger protein 48 2 2
MIRT651197 ZNF281 zinc finger protein 281 2 2
MIRT651682 VPS13D vacuolar protein sorting 13 homolog D 2 2
MIRT651995 UBA6 ubiquitin like modifier activating enzyme 6 2 2
MIRT652062 TTC39B tetratricopeptide repeat domain 39B 2 2
MIRT652310 TNRC6B trinucleotide repeat containing 6B 2 2
MIRT654265 RGS17 regulator of G protein signaling 17 2 2
MIRT654402 RBBP4 RB binding protein 4, chromatin remodeling factor 2 2
MIRT654679 PSMB5 proteasome subunit beta 5 2 2
MIRT654741 PRKCB protein kinase C beta 2 2
MIRT656172 MRPL44 mitochondrial ribosomal protein L44 2 2
MIRT656583 LSAMP limbic system-associated membrane protein 2 2
MIRT656700 LNPEP leucyl and cystinyl aminopeptidase 2 2
MIRT657492 HBEGF heparin binding EGF like growth factor 2 2
MIRT658487 EXOC7 exocyst complex component 7 2 2
MIRT658583 EPHB1 EPH receptor B1 2 2
MIRT658657 EMX2 empty spiracles homeobox 2 2 2
MIRT659123 DENND5B DENN domain containing 5B 2 2
MIRT659188 CYSLTR2 cysteinyl leukotriene receptor 2 2 2
MIRT659329 CSNK2A1 casein kinase 2 alpha 1 2 2
MIRT660376 B4GALT6 beta-1,4-galactosyltransferase 6 2 2
MIRT660636 ANKRD50 ankyrin repeat domain 50 2 2
MIRT660689 ANAPC1 anaphase promoting complex subunit 1 2 4
MIRT662434 RALGAPA1 Ral GTPase activating protein catalytic alpha subunit 1 2 2
MIRT662562 IL2RA interleukin 2 receptor subunit alpha 2 2
MIRT662966 ZSWIM1 zinc finger SWIM-type containing 1 2 2
MIRT666429 SH2B3 SH2B adaptor protein 3 2 2
MIRT668902 CREB1 cAMP responsive element binding protein 1 2 2
MIRT673056 AGO3 argonaute 3, RISC catalytic component 2 2
MIRT687429 NR3C1 nuclear receptor subfamily 3 group C member 1 2 2
MIRT694785 DHFRL1 dihydrofolate reductase 2 2 2
MIRT708677 ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 2 2
MIRT708853 TMSB4X thymosin beta 4, X-linked 2 2
MIRT709605 CXorf23 BCLAF1 and THRAP3 family member 3 2 2
MIRT709993 IFIT1 interferon induced protein with tetratricopeptide repeats 1 2 2
MIRT710881 MTG1 mitochondrial ribosome associated GTPase 1 2 2
MIRT711023 MBOAT2 membrane bound O-acyltransferase domain containing 2 2 2
MIRT711338 FMNL2 formin like 2 2 2
MIRT711351 HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 2 2
MIRT712163 SURF4 surfeit 4 2 2
MIRT712225 RIMS3 regulating synaptic membrane exocytosis 3 2 2
MIRT713028 MAP3K2 mitogen-activated protein kinase kinase kinase 2 2 2
MIRT713719 CD244 CD244 molecule 2 2
MIRT713970 ASIC4 acid sensing ion channel subunit family member 4 2 2
MIRT714872 SPDL1 spindle apparatus coiled-coil protein 1 2 2
MIRT715837 SZT2 SZT2, KICSTOR complex subunit 2 2
MIRT717031 KRTAP4-9 keratin associated protein 4-9 2 2
MIRT717158 SHB SH2 domain containing adaptor protein B 2 2
MIRT717292 KCTD20 potassium channel tetramerization domain containing 20 2 2
MIRT717670 CDC42BPA CDC42 binding protein kinase alpha 2 2
MIRT717838 NEGR1 neuronal growth regulator 1 2 2
MIRT718148 TTC33 tetratricopeptide repeat domain 33 2 2
MIRT719726 SLC39A11 solute carrier family 39 member 11 2 2
MIRT719909 IL5 interleukin 5 2 2
MIRT720245 FAM83F family with sequence similarity 83 member F 2 2
MIRT720352 AHCYL2 adenosylhomocysteinase like 2 2 2
MIRT720803 NUDT5 nudix hydrolase 5 2 2
MIRT720930 PPP1R3E protein phosphatase 1 regulatory subunit 3E 2 2
MIRT721609 PPP1CB protein phosphatase 1 catalytic subunit beta 2 2
MIRT722090 SUSD1 sushi domain containing 1 2 2
MIRT722271 LURAP1 leucine rich adaptor protein 1 2 2
MIRT722548 FGFR1OP FGFR1 oncogene partner 2 2
MIRT723141 METTL24 methyltransferase like 24 2 2
MIRT723271 TAL2 TAL bHLH transcription factor 2 2 2
MIRT723396 OAF out at first homolog 2 2
MIRT723633 STK25 serine/threonine kinase 25 2 2
MIRT723680 CIRH1A UTP4, small subunit processome component 2 2
MIRT723803 BDKRB2 bradykinin receptor B2 2 2
MIRT723894 NUDT21 nudix hydrolase 21 2 2
MIRT724672 NCAPG non-SMC condensin I complex subunit G 2 2
MIRT724759 PSG4 pregnancy specific beta-1-glycoprotein 4 2 2
MIRT724973 TNS1 tensin 1 2 2
MIRT725046 ZFP36L1 ZFP36 ring finger protein like 1 2 2
MIRT725428 HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-6868-3p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-6868-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-miR-6868-3p Docetaxel+Cisplatin+5-Fluorouracil resistant tissue (hypopharyngeal squamous cell carcinoma)

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