pre-miRNA Information
pre-miRNA hsa-mir-2115   
Genomic Coordinates chr3: 48316360 - 48316459
Description Homo sapiens miR-2115 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-2115-3p
Sequence 58| CAUCAGAAUUCAUGGAGGCUAG |79
Evidence Experimental
Experiments 454
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN31490809 22 COSMIC
COSN31579735 22 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs543123304 18 dbSNP
rs1450988157 21 dbSNP
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol MGARP   
Synonyms C4orf49, CESP-1, HUMMR, OSAP
Description mitochondria localized glutamic acid rich protein
Transcript NM_032623   
Expression
Putative miRNA Targets on MGARP
3'UTR of MGARP
(miRNA target sites are highlighted)
>MGARP|NM_032623|3'UTR
   1 TCTCCAGCCGGTAGACATTTCAGCAACAAATGCCATAGGGTGTCTGATAAGTGCTTTTGTGTTTTTAGTACACTTAGTTT
  81 AAAAAAAAAAAGACTTATTTTCTAGAAAACGTTAATGGGTCTTGAAGATTTTTGGCATCCACTGATAGATTTTAGGACTG
 161 AGAGACTTGAGATTGTACATTTCTTACTACTCTTCTACTGTCTGAGATCAGAATATGACATTGCAGTAAAGAGCTTAAAT
 241 AGTTTCATCTTTGGTTTTTTTTTCTAGACACTTTTCTTTTATCCCAGTCATCTCTGAATTTACATTTTATATTAAAGAAA
 321 TTGAGCTATCCATACAACCTGTATTTACTTTAATTTCACTATGCTTTCAGCTTACTTTATTGTATGATATGTAGGTCTAA
 401 AATATAGTTTGAGTCAAATAAAATTAGAAAAGCTTT
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' gaucggaGGUA-CUUA-AGACUAc 5'
                 |||| |::| |||||| 
Target 5' acaaatgCCATAGGGTGTCTGATa 3'
26 - 49 127.00 -11.60
2
miRNA  3' gaUCGGAGGUACUUAAGACUac 5'
            :|:||: | || ||:||:  
Target 5' tgGGTCTTGAAGATTTTTGGca 3'
116 - 137 112.00 -9.00
3
miRNA  3' gaucGGAGGU-ACUUAAGACUac 5'
              |:||:| ||   |||||  
Target 5' tactCTTCTACTG---TCTGAga 3'
188 - 207 106.00 -9.70
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN22590074 7 COSMIC
COSN31613574 22 COSMIC
COSN31605404 54 COSMIC
COSN31579239 61 COSMIC
COSN20100546 80 COSMIC
COSN1288324 81 COSMIC
COSN20164294 108 COSMIC
COSN31542366 127 COSMIC
COSN31484660 156 COSMIC
COSN9904364 308 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs777039382 1 dbSNP
rs769022355 3 dbSNP
rs1362430264 6 dbSNP
rs1315426912 8 dbSNP
rs775038659 9 dbSNP
rs368593415 10 dbSNP
rs745416763 17 dbSNP
rs757326727 23 dbSNP
rs749220580 29 dbSNP
rs374477941 31 dbSNP
rs1000380717 36 dbSNP
rs1380107925 38 dbSNP
rs755975260 39 dbSNP
rs1446722178 41 dbSNP
rs752494954 44 dbSNP
rs766561025 51 dbSNP
rs902836217 69 dbSNP
rs1355636008 72 dbSNP
rs1279569776 80 dbSNP
rs994146436 81 dbSNP
rs963035875 91 dbSNP
rs202133262 92 dbSNP
rs879242379 92 dbSNP
rs1016975233 93 dbSNP
rs74409545 95 dbSNP
rs1338679675 102 dbSNP
rs149607840 119 dbSNP
rs1039637798 128 dbSNP
rs1051247390 129 dbSNP
rs1405172004 135 dbSNP
rs998374687 137 dbSNP
rs116191353 141 dbSNP
rs1053288334 145 dbSNP
rs935643244 155 dbSNP
rs760181856 160 dbSNP
rs1447980715 162 dbSNP
rs1410443632 171 dbSNP
rs1159178476 177 dbSNP
rs1469711121 179 dbSNP
rs1420794291 188 dbSNP
rs1433150783 191 dbSNP
rs1236860480 195 dbSNP
rs904187330 196 dbSNP
rs1470349112 215 dbSNP
rs1462040668 218 dbSNP
rs1044103834 221 dbSNP
rs1386759829 225 dbSNP
rs1242978381 228 dbSNP
rs372871458 230 dbSNP
rs1208475249 239 dbSNP
rs948627866 254 dbSNP
rs1362548456 255 dbSNP
rs78918614 261 dbSNP
rs1222687748 264 dbSNP
rs1280804076 264 dbSNP
rs992590031 267 dbSNP
rs972067239 270 dbSNP
rs566330680 271 dbSNP
rs1317073158 275 dbSNP
rs1246698541 276 dbSNP
rs971600701 282 dbSNP
rs1381962657 311 dbSNP
rs1334374658 333 dbSNP
rs1197815984 334 dbSNP
rs1168211955 341 dbSNP
rs1271703576 356 dbSNP
rs1480778560 363 dbSNP
rs1158562600 364 dbSNP
rs1409993452 366 dbSNP
rs1024559487 383 dbSNP
rs1161003809 384 dbSNP
rs1345637819 386 dbSNP
rs1435503941 390 dbSNP
rs929147716 408 dbSNP
rs1347344572 414 dbSNP
rs1347134828 423 dbSNP
rs1287201869 431 dbSNP
rs918629887 432 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions hESCs (WA-09)
Disease 84709.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in SRR359787. RNA binding protein: AGO2. Condition:4-thiouridine ...

- Lipchina I; Elkabetz Y; Hafner M; Sheridan et al., 2011, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' gaucggagguacuuAAGACuac 5'
                        ||:||   
Target 5' -------uaagugcUUUUGugu 3'
1 - 15
Article - Lipchina I; Elkabetz Y; Hafner M; Sheridan et al.
- Genes & development, 2011
MicroRNAs are important regulators in many cellular processes, including stem cell self-renewal. Recent studies demonstrated their function as pluripotency factors with the capacity for somatic cell reprogramming. However, their role in human embryonic stem (ES) cells (hESCs) remains poorly understood, partially due to the lack of genome-wide strategies to identify their targets. Here, we performed comprehensive microRNA profiling in hESCs and in purified neural and mesenchymal derivatives. Using a combination of AGO cross-linking and microRNA perturbation experiments, together with computational prediction, we identified the targets of the miR-302/367 cluster, the most abundant microRNAs in hESCs. Functional studies identified novel roles of miR-302/367 in maintaining pluripotency and regulating hESC differentiation. We show that in addition to its role in TGF-beta signaling, miR-302/367 promotes bone morphogenetic protein (BMP) signaling by targeting BMP inhibitors TOB2, DAZAP2, and SLAIN1. This study broadens our understanding of microRNA function in hESCs and is a valuable resource for future studies in this area.
LinkOut: [PMID: 22012620]
CLIP-seq Support 1 for dataset SRR359787
Method / RBP PAR-CLIP / AGO2
Cell line / Condition hESCs (WA-09) / 4-thiouridine, RNase T1
Location of target site ENST00000398955.1 | 3UTR | UAAGUGCUUUUGUGUUUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22012620 / SRX103431
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
80 hsa-miR-2115-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT057089 DDIT4 DNA damage inducible transcript 4 2 2
MIRT071216 FCF1 FCF1, rRNA-processing protein 2 2
MIRT226901 RAD23B RAD23 homolog B, nucleotide excision repair protein 2 2
MIRT235961 BACH1 BTB domain and CNC homolog 1 2 2
MIRT294569 ZNF460 zinc finger protein 460 2 4
MIRT321046 RAC1 Rac family small GTPase 1 2 4
MIRT359666 NUS1 NUS1 dehydrodolichyl diphosphate synthase subunit 2 8
MIRT366451 KLHL15 kelch like family member 15 2 2
MIRT405375 ZBTB18 zinc finger and BTB domain containing 18 2 2
MIRT441794 TCEAL5 transcription elongation factor A like 5 2 2
MIRT443295 TCEAL3 transcription elongation factor A like 3 2 2
MIRT455275 DDX39B DExD-box helicase 39B 2 2
MIRT458523 C5orf22 chromosome 5 open reading frame 22 2 2
MIRT464960 TWIST1 twist family bHLH transcription factor 1 2 2
MIRT466848 STX6 syntaxin 6 2 2
MIRT469252 RHOB ras homolog family member B 2 2
MIRT469825 RAB14 RAB14, member RAS oncogene family 2 4
MIRT470047 PTGFRN prostaglandin F2 receptor inhibitor 2 2
MIRT471420 PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 2 2
MIRT472024 NPM1 nucleophosmin 1 2 2
MIRT484156 CENPN centromere protein N 2 2
MIRT485490 HMGN2 high mobility group nucleosomal binding domain 2 2 2
MIRT490462 PROSER2 proline and serine rich 2 2 2
MIRT493069 MTCH1 mitochondrial carrier 1 2 2
MIRT493573 HSP90AA1 heat shock protein 90 alpha family class A member 1 2 8
MIRT494919 NDUFC2-KCTD14 NDUFC2-KCTD14 readthrough 2 2
MIRT500439 ZMAT3 zinc finger matrin-type 3 2 2
MIRT500931 SRPR SRP receptor alpha subunit 2 4
MIRT501551 POC1B-GALNT4 POC1B-GALNT4 readthrough 2 2
MIRT501809 NEURL1B neuralized E3 ubiquitin protein ligase 1B 2 2
MIRT502415 GALNT4 polypeptide N-acetylgalactosaminyltransferase 4 2 2
MIRT506504 MSANTD4 Myb/SANT DNA binding domain containing 4 with coiled-coils 2 2
MIRT507861 CCNE2 cyclin E2 2 2
MIRT510511 YOD1 YOD1 deubiquitinase 2 6
MIRT516073 RAB42 RAB42, member RAS oncogene family 2 2
MIRT519030 KYNU kynureninase 2 6
MIRT521762 PPIL1 peptidylprolyl isomerase like 1 2 4
MIRT522898 KCNJ3 potassium voltage-gated channel subfamily J member 3 2 4
MIRT527370 MGARP mitochondria localized glutamic acid rich protein 2 2
MIRT530691 C8orf46 chromosome 8 open reading frame 46 2 2
MIRT530867 TRUB1 TruB pseudouridine synthase family member 1 2 2
MIRT531832 MTPAP mitochondrial poly(A) polymerase 2 4
MIRT533035 ZBTB5 zinc finger and BTB domain containing 5 2 2
MIRT533165 WIPF2 WAS/WASL interacting protein family member 2 2 2
MIRT533464 TRIM71 tripartite motif containing 71 2 2
MIRT534331 SHCBP1 SHC binding and spindle associated 1 2 2
MIRT539372 ADSS adenylosuccinate synthase 2 6
MIRT545951 ZBTB10 zinc finger and BTB domain containing 10 2 2
MIRT553283 TSR1 TSR1, ribosome maturation factor 2 2
MIRT553532 TMEM185B transmembrane protein 185B 2 4
MIRT556480 LIPA lipase A, lysosomal acid type 2 2
MIRT556975 HSPA4L heat shock protein family A (Hsp70) member 4 like 2 2
MIRT557697 GATA6 GATA binding protein 6 2 2
MIRT558901 CCDC58 coiled-coil domain containing 58 2 2
MIRT559224 BLMH bleomycin hydrolase 2 2
MIRT559827 SLPI secretory leukocyte peptidase inhibitor 2 2
MIRT563435 SLC3A2 solute carrier family 3 member 2 2 2
MIRT569270 PCDH11X protocadherin 11 X-linked 2 2
MIRT571386 JKAMP JNK1/MAPK8-associated membrane protein 2 2
MIRT572567 AFF1 AF4/FMR2 family member 1 2 2
MIRT610400 AR androgen receptor 2 2
MIRT611058 ZNF621 zinc finger protein 621 2 2
MIRT635118 TMEM233 transmembrane protein 233 2 2
MIRT641617 DEFB118 defensin beta 118 2 2
MIRT642146 CHORDC1 cysteine and histidine rich domain containing 1 2 2
MIRT647295 C8orf33 chromosome 8 open reading frame 33 2 2
MIRT648155 MPLKIP M-phase specific PLK1 interacting protein 2 2
MIRT652780 TENM3 teneurin transmembrane protein 3 2 2
MIRT657356 HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 2 2
MIRT658718 ELN elastin 2 2
MIRT662441 RALGAPA1 Ral GTPase activating protein catalytic alpha subunit 1 2 2
MIRT665302 ZBTB38 zinc finger and BTB domain containing 38 2 2
MIRT699898 RUNX1 runt related transcription factor 1 2 2
MIRT700921 PDS5A PDS5 cohesin associated factor A 2 2
MIRT700992 PDE3A phosphodiesterase 3A 2 2
MIRT707397 DCAF4L1 DDB1 and CUL4 associated factor 4 like 1 2 2
MIRT711895 INSIG2 insulin induced gene 2 2 2
MIRT712072 XRCC5 X-ray repair cross complementing 5 2 2
MIRT716121 PTPLAD2 3-hydroxyacyl-CoA dehydratase 4 1 1
MIRT724470 SMAD2 SMAD family member 2 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-2115 Docetaxel+Cisplatin+5-Fluorouracil sensitive tissue (hypopharyngeal squamous cell carcinoma)
hsa-mir-2115 Decitabine 451668 approved sensitive tissue (esopheageal cancer)
hsa-miR-2115-3p Imatinib 5291 NSC743414 approved resistant High Chronic Myelogenous Leukemia cell line (K562)
hsa-miR-2115-3p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-2115-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-2115-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-miR-2115-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-2115-3p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-miR-2115-3p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)

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