miRTarBase - #MIRT527428


—
pre-miRNA Information
pre-miRNA hsa-mir-216b   
Genomic Coordinates chr2: 56000714 - 56000795
Description Homo sapiens miR-216b stem-loop
Comment This sequence was identified as a miRNA candidate by Berezikov et al. using RAKE and MPSS techniques .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-216b-3p
Sequence 49| ACACACUUACCCGUAGAGAUUCUA |72
Evidence Experimental
Experiments Illumina
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 9 2 - 56000739 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1032185572 4 dbSNP
rs1291886633 6 dbSNP
rs1195180466 10 dbSNP
rs761473579 10 dbSNP
rs751204276 12 dbSNP
rs368125248 13 dbSNP
rs755646560 13 dbSNP
rs1307586870 14 dbSNP
rs907200088 16 dbSNP
rs763696104 22 dbSNP
rs762699560 24 dbSNP
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Biomarker Information
Biomarker ID Name Type Discovered From Mode Level Source Testing Methods
B5PHM2 miR-216b Safety Biomarker (SAF) Clinical/Experimental Data Expression Increase Plasma MiRNA qPCR analyses
Gene Information
Gene Symbol NRL   
Synonyms D14S46E, NRL-MAF, RP27
Description neural retina leucine zipper
Transcript NM_006177   
Expression
Putative miRNA Targets on NRL
3'UTR of NRL
(miRNA target sites are highlighted)		 
>NRL|NM_006177|3'UTR
   1 GCCGTTCAGAGCACCTTGTGGTGTAGTGGGGGCTGGGTGGGGTGGCTCCGCCCAGGAGGCGGCTGCACGGTTCTCTGCAT
  81 CGTTACCAGAGCGCCTTCTGGTCCTAGCCACGCCCTGTATGACCGCGCAAATATCCCCAAAGCTTTTGGGTCCTCAAGTC
 161 ATGCCCGAATTTAGATGCTGGTCATTTTCTGGAGAGGGGTCCCCTCCCCTTACGAACACAGAAACCCAGCCCACATGACT
 241 AGCACGCTGAGCTCTGCAGGGACCAGTGCCAGGCACTGGGGGGTGGAAGTGTGGTGACACAGTGAATGGGAGGTGGAGGA
 321 GGGTTGCAGCTCCCACCTCAGTTTAGTTTTTAATTCAGGGTTTTCAACCTGTAACACATTAAAGCTGTAATTAGCAATGA
 401 GGCTGTATTTTCATTCTGAAGCTTGTAACCTCCCCATTTTAGCACTACAGAATTTTCAAGATTTCAATATCCAACAACTA
 481 GATAGATTAGGACCTCTATCCGAGATGCTTTTTCCCTGCCCAACCCTGTGGCCTTCAGGGCTCAGAGCAGCAAAGGCCTG
 561 AAGAGTGAGCTCTGGGGGTTGTTGGTGTGGGTTGGGAGAGAGCTGTGTGCAGAAGTCTGGAAACCTGGGTCCTAGTCCCA
 641 GCTCTTCCATGGGATCCCCCTGTCACCCTGAGCAAATCAGTTGCTTCCTGGACTTGTGTTACTTCATCTAATTCTCATGT
 721 GGATTGGACGACTTCTGCTCCCTTTCCAGTTCTGGCATCTCCCCAGTATGGAAGTCCCGGTGGTCTCCCCAAGAAGTCCC
 801 CAAGACAATCTCGCCAAAGGCACCTCCTATCCTGCTGCAGTTTCCCAGCTGCAGCCTAGGCAGGGGATGCACAGCCCAGG
 881 CGAGGAAGCCTGGCTTCTCTGTGAGCACATACGTGGGTCCTCGGCAGCTCCCTCCAGGCTGTCTGGGCCTCCAGACCTGC
 961 ACAGGGTGCTCCTGCCACCTCCCACCTCTCTGAGGGCTGAGGTGAGACTTCTCCTGGGATGACAATTTGCTGAGAGAGTG
1041 CAGCTTTTGTGAATTAAACTTGAAGTCCAGGCAGAATTCTAATGCAATAAGCTAAATGTTCTTGCAATTTAAGAAGTGTT
1121 CATTCTTTA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' aucUUAGAGA-UGCCCA--UUCACACa 5'
             |: | || : ||||  ||||||| 
Target 5' gccAGGCACTGGGGGGTGGAAGTGTGg 3'
 268 - 294 155.00 -18.40
2 
miRNA  3' auCUUA---GAGAUGCC---CAUUCACACa 5'
            ||:|   ||||: ||   || :||||| 
Target 5' aaGAGTGAGCTCTGGGGGTTGTTGGTGTGg 3'
 561 - 590 122.00 -23.50
3 
miRNA  3' auCU-UAGAGAUGCCCAUUCACACa 5'
            || | || |::|   |||| || 
Target 5' gaGAGAGCTGTGTGCAGAAGTCTGg 3'
 596 - 620 122.00 -10.30
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
312940 56 ClinVar
312939 108 ClinVar
312938 113 ClinVar
312937 173 ClinVar
312936 213 ClinVar
312935 221 ClinVar
312934 284 ClinVar
882237 301 ClinVar
312933 472 ClinVar
312932 480 ClinVar
312931 558 ClinVar
312930 667 ClinVar
880865 673 ClinVar
880864 778 ClinVar
312929 780 ClinVar
312928 813 ClinVar
312927 834 ClinVar
884148 864 ClinVar
312926 935 ClinVar
312925 1043 ClinVar
312924 1118 ClinVar
312923 1127 ClinVar
COSN26604312 3 COSMIC
COSN213173 20 COSMIC
COSN30538016 24 COSMIC
COSN5746960 122 COSMIC
COSN29283086 206 COSMIC
COSN30530071 288 COSMIC
COSN8548604 501 COSMIC
COSN31565974 502 COSMIC
COSN32058591 779 COSMIC
COSN31606950 804 COSMIC
COSN6243213 1077 COSMIC
rs743271 1878 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs764462511 3 dbSNP
rs1034206043 4 dbSNP
rs1415389614 12 dbSNP
rs756374849 14 dbSNP
rs1476281882 15 dbSNP
rs1299692443 16 dbSNP
rs753179989 16 dbSNP
rs1432413074 18 dbSNP
rs1435516339 23 dbSNP
rs767716497 27 dbSNP
rs760092291 28 dbSNP
rs1176148036 32 dbSNP
rs1286496074 35 dbSNP
rs1369639095 38 dbSNP
rs1206232312 40 dbSNP
rs1356260437 41 dbSNP
rs1271602408 42 dbSNP
rs972422686 48 dbSNP
rs1235559623 49 dbSNP
rs774679033 50 dbSNP
rs961614639 53 dbSNP
rs1016823518 54 dbSNP
rs886050428 56 dbSNP
rs1248863014 60 dbSNP
rs548894842 68 dbSNP
rs140157008 69 dbSNP
rs1437282021 70 dbSNP
rs750437525 74 dbSNP
rs1408250570 78 dbSNP
rs752674088 79 dbSNP
rs1162403118 82 dbSNP
rs1225800955 84 dbSNP
rs996297728 87 dbSNP
rs1330597048 92 dbSNP
rs569332440 99 dbSNP
rs1374679139 104 dbSNP
rs552709917 108 dbSNP
rs1040802848 112 dbSNP
rs3560 113 dbSNP
rs1355866876 114 dbSNP
rs892053867 116 dbSNP
rs1292412044 119 dbSNP
rs1054688393 120 dbSNP
rs1198501753 123 dbSNP
rs1236901436 124 dbSNP
rs1459524801 125 dbSNP
rs1179969069 127 dbSNP
rs1232996224 137 dbSNP
rs1472231455 142 dbSNP
rs936173220 143 dbSNP
rs560174741 152 dbSNP
rs546594803 153 dbSNP
rs530034913 156 dbSNP
rs1169764848 162 dbSNP
rs1435860839 163 dbSNP
rs1371305380 164 dbSNP
rs770345705 166 dbSNP
rs748736076 171 dbSNP
rs540751400 173 dbSNP
rs541740361 191 dbSNP
rs576212622 192 dbSNP
rs1428104947 194 dbSNP
rs972839479 197 dbSNP
rs562561220 198 dbSNP
rs147146405 199 dbSNP
rs1435384834 203 dbSNP
rs1027887669 204 dbSNP
rs973635554 206 dbSNP
rs1218397600 209 dbSNP
rs79489503 213 dbSNP
rs1190064696 214 dbSNP
rs1483090536 215 dbSNP
rs1273046923 217 dbSNP
rs1441339522 219 dbSNP
rs3561 221 dbSNP
rs1202554227 243 dbSNP
rs906581448 246 dbSNP
rs1192626023 248 dbSNP
rs984004708 250 dbSNP
rs953937268 252 dbSNP
rs1482554007 254 dbSNP
rs1478735278 258 dbSNP
rs1009498319 263 dbSNP
rs1028201803 265 dbSNP
rs998002652 278 dbSNP
rs187067743 279 dbSNP
rs966557916 282 dbSNP
rs1399674530 284 dbSNP
rs200281199 284 dbSNP
rs1276678067 287 dbSNP
rs1053659558 294 dbSNP
rs533816303 298 dbSNP
rs1019002721 301 dbSNP
rs754089933 302 dbSNP
rs574615388 307 dbSNP
rs1274786910 311 dbSNP
rs1343557422 329 dbSNP
rs574474899 330 dbSNP
rs755468700 337 dbSNP
rs899701976 356 dbSNP
rs1010669614 364 dbSNP
rs1485780667 372 dbSNP
rs891754128 394 dbSNP
rs747396606 396 dbSNP
rs1224334526 399 dbSNP
rs943794900 401 dbSNP
rs780508032 406 dbSNP
rs1193739179 420 dbSNP
rs1376990172 421 dbSNP
rs1477040596 424 dbSNP
rs1000436978 429 dbSNP
rs1174362874 432 dbSNP
rs1395824433 435 dbSNP
rs1419284922 441 dbSNP
rs879792464 443 dbSNP
rs758697912 457 dbSNP
rs1296585099 460 dbSNP
rs1362779144 463 dbSNP
rs555330815 472 dbSNP
rs878872233 474 dbSNP
rs1351146257 478 dbSNP
rs886050427 480 dbSNP
rs950206569 494 dbSNP
rs1046783071 496 dbSNP
rs538179231 497 dbSNP
rs1348016792 498 dbSNP
rs919582016 506 dbSNP
rs1283456302 507 dbSNP
rs1486675856 509 dbSNP
rs1036745333 514 dbSNP
rs973686002 516 dbSNP
rs569498952 532 dbSNP
rs1370221273 535 dbSNP
rs959649011 540 dbSNP
rs558895040 550 dbSNP
rs1449775533 555 dbSNP
rs1200943822 556 dbSNP
rs114327952 558 dbSNP
rs1357847547 560 dbSNP
rs1156988623 564 dbSNP
rs1175975034 568 dbSNP
rs376517720 581 dbSNP
rs909585258 582 dbSNP
rs766085808 587 dbSNP
rs983787291 592 dbSNP
rs1454538946 594 dbSNP
rs1163016972 595 dbSNP
rs1388993273 600 dbSNP
rs982271740 615 dbSNP
rs566674724 624 dbSNP
rs1445386764 634 dbSNP
rs1472039829 642 dbSNP
rs1306542577 645 dbSNP
rs971236127 649 dbSNP
rs546682364 654 dbSNP
rs932581387 657 dbSNP
rs921170816 658 dbSNP
rs958065128 662 dbSNP
rs1482149262 664 dbSNP
rs555110362 667 dbSNP
rs996722399 679 dbSNP
rs1331165923 682 dbSNP
rs1176822229 683 dbSNP
rs1240156988 702 dbSNP
rs1290245782 711 dbSNP
rs567298055 714 dbSNP
rs1419842929 718 dbSNP
rs1187142602 731 dbSNP
rs373376079 753 dbSNP
rs965216246 755 dbSNP
rs1350042431 759 dbSNP
rs1019447316 766 dbSNP
rs1400208770 769 dbSNP
rs1278072406 772 dbSNP
rs1464561317 773 dbSNP
rs762694845 778 dbSNP
rs956309899 779 dbSNP
rs886050426 780 dbSNP
rs1377394912 783 dbSNP
rs1008038982 785 dbSNP
rs369798445 785 dbSNP
rs1338392725 788 dbSNP
rs1458186823 791 dbSNP
rs757264631 798 dbSNP
rs1317201283 802 dbSNP
rs527728224 803 dbSNP
rs1046877270 808 dbSNP
rs1456231347 812 dbSNP
rs560755924 813 dbSNP
rs1200030787 814 dbSNP
rs1254322183 826 dbSNP
rs1476348045 827 dbSNP
rs763970615 829 dbSNP
rs1051718 834 dbSNP
rs1255148989 838 dbSNP
rs1188979568 849 dbSNP
rs1466167919 856 dbSNP
rs906154950 864 dbSNP
rs938273459 878 dbSNP
rs1399567187 881 dbSNP
rs1001819424 882 dbSNP
rs1208082056 894 dbSNP
rs199728110 895 dbSNP
rs926870454 896 dbSNP
rs1339628104 897 dbSNP
rs1216649547 903 dbSNP
rs149452249 909 dbSNP
rs970947788 912 dbSNP
rs1037597903 913 dbSNP
rs1232618696 913 dbSNP
rs939824665 922 dbSNP
rs545682174 923 dbSNP
rs1211898073 926 dbSNP
rs1262873622 927 dbSNP
rs1487516971 930 dbSNP
rs184235122 935 dbSNP
rs1048117703 937 dbSNP
rs1324856953 941 dbSNP
rs1436312123 942 dbSNP
rs775281644 949 dbSNP
rs932275292 965 dbSNP
rs1436152998 966 dbSNP
rs921198462 975 dbSNP
rs1367862787 977 dbSNP
rs976628634 980 dbSNP
rs560329228 990 dbSNP
rs1359595533 993 dbSNP
rs1397900144 995 dbSNP
rs1290482182 996 dbSNP
rs1362535708 1001 dbSNP
rs1386193148 1004 dbSNP
rs1299227020 1025 dbSNP
rs1350188652 1037 dbSNP
rs775416749 1038 dbSNP
rs988224168 1041 dbSNP
rs767236932 1043 dbSNP
rs1285560125 1046 dbSNP
rs1435099139 1055 dbSNP
rs958076227 1057 dbSNP
rs759255402 1061 dbSNP
rs1218342769 1065 dbSNP
rs192098457 1071 dbSNP
rs574558502 1074 dbSNP
rs1243101319 1085 dbSNP
rs773864629 1115 dbSNP
rs554283773 1116 dbSNP
rs544154741 1117 dbSNP
rs77284446 1118 dbSNP
rs113119768 1127 dbSNP
rs1455202454 1129 dbSNP
rs1367564177 1135 dbSNP
rs1168938562 1141 dbSNP
rs138000926 1142 dbSNP
rs187609793 1143 dbSNP
rs1345593709 1146 dbSNP
rs1291723935 1149 dbSNP
rs1373218100 1152 dbSNP
rs150321333 1158 dbSNP
rs1025482727 1166 dbSNP
rs995259583 1176 dbSNP
rs898216829 1181 dbSNP
rs1285341428 1184 dbSNP
rs772725218 1185 dbSNP
rs1268072497 1187 dbSNP
rs1055484812 1191 dbSNP
rs937045135 1191 dbSNP
rs1211716883 1192 dbSNP
rs1046677974 1193 dbSNP
rs541263160 1193 dbSNP
rs1178612755 1195 dbSNP
rs969992284 1198 dbSNP
rs1404568092 1199 dbSNP
rs146511639 1199 dbSNP
rs573643336 1199 dbSNP
rs1396554252 1209 dbSNP
rs1023180666 1228 dbSNP
rs1330700117 1237 dbSNP
rs183851849 1241 dbSNP
rs1344757341 1246 dbSNP
rs1280370875 1251 dbSNP
rs960565528 1255 dbSNP
rs1226962097 1256 dbSNP
rs1295544643 1260 dbSNP
rs567386259 1264 dbSNP
rs1015785202 1267 dbSNP
rs1004774741 1268 dbSNP
rs550705806 1273 dbSNP
rs1206115048 1281 dbSNP
rs530886943 1285 dbSNP
rs569101920 1295 dbSNP
rs1048147455 1300 dbSNP
rs975886206 1302 dbSNP
rs964107543 1303 dbSNP
rs1419782676 1304 dbSNP
rs1475469407 1309 dbSNP
rs1169878504 1310 dbSNP
rs1324909459 1324 dbSNP
rs1020026606 1325 dbSNP
rs1411715791 1325 dbSNP
rs986777836 1330 dbSNP
rs1389448998 1335 dbSNP
rs759337548 1341 dbSNP
rs1413224503 1345 dbSNP
rs1315118295 1349 dbSNP
rs769052205 1352 dbSNP
rs1431319691 1354 dbSNP
rs1388073989 1358 dbSNP
rs1356540987 1359 dbSNP
rs1218495191 1367 dbSNP
rs899467236 1368 dbSNP
rs1478275172 1385 dbSNP
rs747453516 1391 dbSNP
rs1379328500 1395 dbSNP
rs552437864 1400 dbSNP
rs1025494271 1406 dbSNP
rs1432099785 1412 dbSNP
rs62000824 1415 dbSNP
rs1259273881 1416 dbSNP
rs1485883437 1417 dbSNP
rs12888763 1420 dbSNP
rs1052306715 1421 dbSNP
rs1034127184 1422 dbSNP
rs746519700 1425 dbSNP
rs1476374877 1435 dbSNP
rs1168547126 1438 dbSNP
rs540394410 1445 dbSNP
rs1206125646 1456 dbSNP
rs529825570 1457 dbSNP
rs1045771416 1462 dbSNP
rs1272851298 1462 dbSNP
rs1316768789 1465 dbSNP
rs949668801 1469 dbSNP
rs560992236 1474 dbSNP
rs1270228407 1475 dbSNP
rs543920649 1481 dbSNP
rs575169334 1482 dbSNP
rs1277098428 1493 dbSNP
rs1231756256 1499 dbSNP
rs1052571214 1503 dbSNP
rs1344317675 1505 dbSNP
rs1215585333 1507 dbSNP
rs936866130 1518 dbSNP
rs1448612882 1520 dbSNP
rs925442393 1528 dbSNP
rs1246135367 1531 dbSNP
rs746139456 1532 dbSNP
rs993217433 1536 dbSNP
rs987174603 1542 dbSNP
rs1307133521 1543 dbSNP
rs951292808 1544 dbSNP
rs1401726182 1546 dbSNP
rs1323492101 1549 dbSNP
rs1369500887 1550 dbSNP
rs1438071028 1568 dbSNP
rs1305040450 1576 dbSNP
rs559023906 1578 dbSNP
rs918528250 1579 dbSNP
rs572546598 1587 dbSNP
rs1477693002 1588 dbSNP
rs1205589979 1591 dbSNP
rs778972248 1593 dbSNP
rs755563812 1597 dbSNP
rs1253724507 1599 dbSNP
rs1439269098 1610 dbSNP
rs1179930301 1612 dbSNP
rs1365848157 1613 dbSNP
rs1163107041 1618 dbSNP
rs1392879560 1627 dbSNP
rs1463520206 1633 dbSNP
rs960346064 1637 dbSNP
rs545277285 1641 dbSNP
rs1182997212 1644 dbSNP
rs1394621569 1647 dbSNP
rs1473673574 1648 dbSNP
rs1249918874 1655 dbSNP
rs1304434156 1658 dbSNP
rs971520267 1659 dbSNP
rs1239503430 1665 dbSNP
rs1292496980 1667 dbSNP
rs573169794 1671 dbSNP
rs111746269 1672 dbSNP
rs1026745815 1681 dbSNP
rs1480355061 1686 dbSNP
rs1194209922 1687 dbSNP
rs996635225 1688 dbSNP
rs891444851 1695 dbSNP
rs899583527 1704 dbSNP
rs113869441 1705 dbSNP
rs1187253607 1707 dbSNP
rs192465074 1708 dbSNP
rs1199231494 1721 dbSNP
rs115212869 1724 dbSNP
rs1052758605 1725 dbSNP
rs780506895 1726 dbSNP
rs925151211 1742 dbSNP
rs1268130451 1747 dbSNP
rs1044872811 1753 dbSNP
rs1296017389 1761 dbSNP
rs574053527 1763 dbSNP
rs948828292 1766 dbSNP
rs1229728558 1776 dbSNP
rs1311999858 1783 dbSNP
rs141292548 1785 dbSNP
rs1278564362 1793 dbSNP
rs1234997881 1797 dbSNP
rs1293814237 1805 dbSNP
rs1306913417 1809 dbSNP
rs1448392561 1823 dbSNP
rs537091055 1825 dbSNP
rs960288144 1827 dbSNP
rs1481053754 1829 dbSNP
rs912612639 1837 dbSNP
rs571600042 1838 dbSNP
rs1189168073 1848 dbSNP
rs1389328841 1849 dbSNP
rs1051167697 1851 dbSNP
rs1427305406 1853 dbSNP
rs372869863 1855 dbSNP
rs929988310 1857 dbSNP
rs908793614 1863 dbSNP
rs918581989 1872 dbSNP
rs743271 1878 dbSNP
rs952934833 1880 dbSNP
rs1313302099 1881 dbSNP
rs1361158700 1886 dbSNP
rs927156544 1889 dbSNP
rs1409901065 1892 dbSNP
rs1176832386 1901 dbSNP
rs1308157129 1902 dbSNP
rs1473281843 1906 dbSNP
rs1233772792 1907 dbSNP
rs980313044 1921 dbSNP
rs1350411198 1922 dbSNP
rs1212008770 1924 dbSNP
rs1260560068 1936 dbSNP
rs1239517808 1938 dbSNP
rs188809172 1940 dbSNP
rs1024499469 1941 dbSNP
rs1009929461 1957 dbSNP
rs1461227284 1958 dbSNP
rs1449528194 1959 dbSNP
rs1192533108 1961 dbSNP
rs533125693 1961 dbSNP
rs138673778 1964 dbSNP
rs963817618 1970 dbSNP
rs1206685657 1988 dbSNP
rs750594709 1989 dbSNP
rs1290577126 2005 dbSNP
rs1362646867 2011 dbSNP
rs1440257887 2012 dbSNP
rs529914539 2019 dbSNP
rs1326419833 2021 dbSNP
rs112604236 2026 dbSNP
rs1019754093 2027 dbSNP
rs1007913025 2028 dbSNP
rs892086902 2031 dbSNP
rs1283915410 2038 dbSNP
rs1228483371 2041 dbSNP
rs1358035065 2049 dbSNP
rs1218449415 2050 dbSNP
rs1039888400 2063 dbSNP
rs1030659060 2071 dbSNP
rs1212496090 2077 dbSNP
rs1282176400 2082 dbSNP
rs78967414 2083 dbSNP
rs762088 2086 dbSNP
rs1406903033 2087 dbSNP
rs182608089 2092 dbSNP
rs1432892537 2093 dbSNP
rs930040700 2101 dbSNP
rs947860733 2117 dbSNP
rs565190137 2119 dbSNP
rs751326715 2119 dbSNP
rs1441840852 2135 dbSNP
rs1057452308 2136 dbSNP
rs1406100985 2140 dbSNP
rs368059904 2141 dbSNP
rs938701343 2147 dbSNP
rs1416267310 2150 dbSNP
rs1161772845 2152 dbSNP
rs1444368596 2153 dbSNP
rs908573862 2157 dbSNP
rs982802570 2158 dbSNP
rs931578589 2163 dbSNP
rs920164404 2167 dbSNP
rs765966837 2175 dbSNP
rs980025425 2199 dbSNP
rs949953927 2203 dbSNP
rs1270659000 2204 dbSNP
rs1463948926 2205 dbSNP
rs964184879 2218 dbSNP
rs917082451 2219 dbSNP
rs988561877 2220 dbSNP
rs1019364205 2223 dbSNP
rs955752437 2225 dbSNP
rs986988672 2228 dbSNP
rs1474819022 2232 dbSNP
rs978371077 2233 dbSNP
rs564915074 2234 dbSNP
rs964389187 2240 dbSNP
rs956480289 2247 dbSNP
rs1031107721 2258 dbSNP
rs1299622310 2259 dbSNP
rs1226009110 2260 dbSNP
rs1328317307 2264 dbSNP
rs1361187234 2266 dbSNP
rs1000474004 2268 dbSNP
rs1193816012 2272 dbSNP
rs1355228783 2272 dbSNP
rs1231935212 2286 dbSNP
rs903791235 2294 dbSNP
rs1295637647 2329 dbSNP
rs189792186 2331 dbSNP
rs1336202039 2340 dbSNP
rs1228365350 2347 dbSNP
rs375365055 2350 dbSNP
rs141128744 2351 dbSNP
rs751653826 2353 dbSNP
rs371780331 2372 dbSNP
rs371253087 2373 dbSNP
rs1185609736 2375 dbSNP
rs535294219 2376 dbSNP
rs1301486283 2386 dbSNP
rs994260949 2395 dbSNP
rs1417495817 2399 dbSNP
rs1056295517 2401 dbSNP
rs1169480612 2405 dbSNP
rs1391112617 2410 dbSNP
rs77644489 2412 dbSNP
rs887182189 2416 dbSNP
rs1430674899 2421 dbSNP
rs1269041862 2424 dbSNP
rs941382339 2442 dbSNP
rs761321489 2447 dbSNP
rs557208534 2448 dbSNP
rs1419455658 2452 dbSNP
rs1346790604 2455 dbSNP
rs1192337051 2479 dbSNP
rs1282220061 2484 dbSNP
rs1442867729 2485 dbSNP
rs931274233 2490 dbSNP
rs1044741158 2498 dbSNP
rs920195466 2499 dbSNP
rs1221259968 2504 dbSNP
rs1483186282 2515 dbSNP
rs1345702285 2516 dbSNP
rs1476419813 2518 dbSNP
rs1276425441 2523 dbSNP
rs1189340532 2525 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions hESCs (WA-09)
Disease 4901.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in SRR359787. RNA binding protein: AGO2. Condition:4-thiouridine ...

- Lipchina I; Elkabetz Y; Hafner M; Sheridan et al., 2011, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' aucuuagagaugcCCA--UUCACACa 5'
                       |||  ||||||| 
Target 5' -------------GGUGGAAGUGUGg 3'
 		1 - 13
Article - Lipchina I; Elkabetz Y; Hafner M; Sheridan et al.
- Genes & development, 2011
MicroRNAs are important regulators in many cellular processes, including stem cell self-renewal. Recent studies demonstrated their function as pluripotency factors with the capacity for somatic cell reprogramming. However, their role in human embryonic stem (ES) cells (hESCs) remains poorly understood, partially due to the lack of genome-wide strategies to identify their targets. Here, we performed comprehensive microRNA profiling in hESCs and in purified neural and mesenchymal derivatives. Using a combination of AGO cross-linking and microRNA perturbation experiments, together with computational prediction, we identified the targets of the miR-302/367 cluster, the most abundant microRNAs in hESCs. Functional studies identified novel roles of miR-302/367 in maintaining pluripotency and regulating hESC differentiation. We show that in addition to its role in TGF-beta signaling, miR-302/367 promotes bone morphogenetic protein (BMP) signaling by targeting BMP inhibitors TOB2, DAZAP2, and SLAIN1. This study broadens our understanding of microRNA function in hESCs and is a valuable resource for future studies in this area.
LinkOut: [PMID: 22012620]
CLIP-seq Support 1 for dataset SRR359787
Method / RBP PAR-CLIP / AGO2
Cell line / Condition hESCs (WA-09) / 4-thiouridine, RNase T1
Location of target site ENST00000397002.2 | 3UTR | GGUGGAAGUGUGGUGACACAGUGAAUGGGAGGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22012620 / SRX103431
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
111 hsa-miR-216b-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT071722 CCNK cyclin K 2 2
MIRT074768 CNEP1R1 CTD nuclear envelope phosphatase 1 regulatory subunit 1 2 2
MIRT101407 SSR1 signal sequence receptor subunit 1 2 2
MIRT241289 AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 2 4
MIRT268292 CCND1 cyclin D1 2 8
MIRT445347 IFNA6 interferon alpha 6 2 2
MIRT446663 MXI1 MAX interactor 1, dimerization protein 2 4
MIRT447595 MSH3 mutS homolog 3 2 2
MIRT448485 SEMA4F ssemaphorin 4F 2 2
MIRT450309 DRAXIN dorsal inhibitory axon guidance protein 2 2
MIRT451850 TXNDC5 thioredoxin domain containing 5 2 2
MIRT483613 SMC5 structural maintenance of chromosomes 5 2 2
MIRT485633 EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 2 2
MIRT499766 CIRH1A UTP4, small subunit processome component 2 6
MIRT503337 MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 2 2
MIRT513007 MAN1A2 mannosidase alpha class 1A member 2 2 2
MIRT513529 RHOQ ras homolog family member Q 2 4
MIRT521499 RAB11B RAB11B, member RAS oncogene family 2 2
MIRT524335 CRK CRK proto-oncogene, adaptor protein 2 4
MIRT524731 BRI3BP BRI3 binding protein 2 8
MIRT525326 SNX29 sorting nexin 29 2 2
MIRT526264 CCDC169 coiled-coil domain containing 169 2 2
MIRT527428 NRL neural retina leucine zipper 2 2
MIRT527512 ZNF134 zinc finger protein 134 2 2
MIRT528881 ATF3 activating transcription factor 3 2 2
MIRT529578 IGBP1 immunoglobulin binding protein 1 2 4
MIRT531122 ZYG11B zyg-11 family member B, cell cycle regulator 2 2
MIRT531341 TGIF2LX TGFB induced factor homeobox 2 like, X-linked 2 2
MIRT532433 DHX33 DEAH-box helicase 33 2 2
MIRT534032 STX7 syntaxin 7 2 2
MIRT534538 SACS sacsin molecular chaperone 2 4
MIRT538886 BRWD3 bromodomain and WD repeat domain containing 3 2 2
MIRT539628 CD19 CD19 molecule 2 8
MIRT540327 ATAT1 alpha tubulin acetyltransferase 1 2 8
MIRT540353 OCLN occludin 2 6
MIRT540699 ATG10 autophagy related 10 2 4
MIRT541033 STRBP spermatid perinuclear RNA binding protein 2 8
MIRT541945 NBPF10 NBPF member 10 2 4
MIRT543505 PLS1 plastin 1 2 2
MIRT551164 UBTF upstream binding transcription factor, RNA polymerase I 2 4
MIRT551790 ZNF117 zinc finger protein 117 2 4
MIRT553227 TWF1 twinfilin actin binding protein 1 2 2
MIRT559622 AKIRIN2 akirin 2 2 2
MIRT559719 ADORA2B adenosine A2b receptor 2 2
MIRT564600 ZNF781 zinc finger protein 781 2 2
MIRT567015 KLHL15 kelch like family member 15 2 2
MIRT569564 C7orf26 chromosome 7 open reading frame 26 2 2
MIRT572155 DDX3X DEAD-box helicase 3, X-linked 2 2
MIRT575399 Zdhhc22 zinc finger, DHHC-type containing 22 2 5
MIRT607322 PKNOX1 PBX/knotted 1 homeobox 1 2 4
MIRT607953 NFAM1 NFAT activating protein with ITAM motif 1 2 10
MIRT607979 ZDHHC22 zinc finger DHHC-type containing 22 2 7
MIRT609145 ZNF610 zinc finger protein 610 2 4
MIRT609206 GOSR2 golgi SNAP receptor complex member 2 2 4
MIRT609338 HRASLS5 HRAS like suppressor family member 5 2 2
MIRT609725 KIF5C kinesin family member 5C 2 4
MIRT610014 MED24 mediator complex subunit 24 2 4
MIRT610407 TMEM245 transmembrane protein 245 2 2
MIRT610559 NBPF14 NBPF member 14 2 2
MIRT611291 PAGR1 PAXIP1 associated glutamate rich protein 1 2 2
MIRT611399 ATP9A ATPase phospholipid transporting 9A (putative) 2 2
MIRT611432 C11orf45 chromosome 11 open reading frame 45 2 4
MIRT611710 SLFN13 schlafen family member 13 2 2
MIRT611721 ANK3 ankyrin 3 2 2
MIRT611830 CACNG8 calcium voltage-gated channel auxiliary subunit gamma 8 2 4
MIRT611977 ZNF175 zinc finger protein 175 2 2
MIRT612073 CEP135 centrosomal protein 135 2 4
MIRT612195 CCDC77 coiled-coil domain containing 77 2 2
MIRT612320 UBE2H ubiquitin conjugating enzyme E2 H 2 2
MIRT612354 TNRC6C trinucleotide repeat containing 6C 2 4
MIRT612635 PTEN phosphatase and tensin homolog 2 2
MIRT612773 MLXIP MLX interacting protein 2 4
MIRT612788 MAP3K9 mitogen-activated protein kinase kinase kinase 9 2 4
MIRT612853 JAZF1 JAZF zinc finger 1 2 2
MIRT612965 GID4 GID complex subunit 4 homolog 2 6
MIRT613132 DUSP6 dual specificity phosphatase 6 2 2
MIRT613388 AAK1 AP2 associated kinase 1 2 2
MIRT615058 CRY2 cryptochrome circadian clock 2 2 4
MIRT616046 HSPA12B heat shock protein family A (Hsp70) member 12B 2 2
MIRT617962 SEPT9 septin 9 2 2
MIRT618413 ATP2A2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 2 2
MIRT622448 RNF213 ring finger protein 213 2 2
MIRT623611 IPCEF1 interaction protein for cytohesin exchange factors 1 2 2
MIRT625709 SHROOM1 shroom family member 1 2 2
MIRT630646 ELK1 ELK1, ETS transcription factor 2 2
MIRT630970 KIAA2022 neurite extension and migration factor 2 2
MIRT631003 SPAG7 sperm associated antigen 7 2 2
MIRT640385 EMC1 ER membrane protein complex subunit 1 2 4
MIRT641064 WBSCR17 polypeptide N-acetylgalactosaminyltransferase 17 2 2
MIRT641780 ZDHHC7 zinc finger DHHC-type containing 7 2 4
MIRT646310 MPHOSPH8 M-phase phosphoprotein 8 2 2
MIRT646624 CENPL centromere protein L 2 2
MIRT659653 CDH2 cadherin 2 2 2
MIRT666161 SP1 Sp1 transcription factor 2 2
MIRT667638 LHFPL2 LHFPL tetraspan subfamily member 2 2 2
MIRT668988 CHRFAM7A CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion 2 2
MIRT680949 PLCXD1 phosphatidylinositol specific phospholipase C X domain containing 1 2 2
MIRT695238 PBK PDZ binding kinase 2 2
MIRT700036 RPL22 ribosomal protein L22 2 2
MIRT707685 GPR50 G protein-coupled receptor 50 2 2
MIRT709324 HMBOX1 homeobox containing 1 2 2
MIRT710176 MTRF1L mitochondrial translational release factor 1 like 2 2
MIRT712007 F9 coagulation factor IX 2 2
MIRT714219 C10orf71 chromosome 10 open reading frame 71 2 2
MIRT714496 HSPA4 heat shock protein family A (Hsp70) member 4 2 2
MIRT714575 GALNT10 polypeptide N-acetylgalactosaminyltransferase 10 2 2
MIRT715982 TFRC transferrin receptor 2 2
MIRT717870 TRAPPC3L trafficking protein particle complex 3 like 2 2
MIRT718289 MINA ribosomal oxygenase 2 2 2
MIRT725200 PTRF caveolae associated protein 1 2 2
MIRT737338 TPX2 TPX2, microtubule nucleation factor 3 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-216b Perfluorooctane sulfonate NULL 74483 Microarray zebrafish embryos 20878907 2011 up-regulated
miR-216b 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) NULL 15625 Microarray embryos 22921993 2012 up-regulated
miR-216b Reversine NULL 210332 Microarray C2C12 myoblast cells 24513286 2014 up-regulated
miR-216b Hydroxycamptothecin (HCPT) NULL 97226 Microarray human Tenon's fibroblasts (HTFs) 24681041 2014 down-regulated
miR-216b Hydroxycamptothecin (HCPT) NULL 97226 Quantitative real-time PCR human Tenon's fibroblasts (HTFs) 24681041 2014 down-regulated
miR-216b Curcumin NULL 969516 Quantitative real-time PCR Y79 RB cells. 22510010 2012 down-regulated
miR-216b Doxorubicin approved 31703 Quantitative real-time PCR heart 22859947 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-216b Paclitaxel 36314 NSC125973 approved sensitive cell line (A2780)
hsa-mir-216b Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-miR-216b-3p Tripterygium wilfordii Hook F resistant tissue
hsa-miR-216b-3p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-216b-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (MGC-803)

Error report submission