miRTarBase - #MIRT527509


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pre-miRNA Information
pre-miRNA hsa-mir-4666a   
Genomic Coordinates chr1: 228462074 - 228462152
Description Homo sapiens miR-4666a stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4666a-5p
Sequence 10| AUACAUGUCAGAUUGUAUGCC |30
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1288210208 3 dbSNP
rs1333314792 5 dbSNP
rs562096649 7 dbSNP
rs1324809033 10 dbSNP
rs1027635037 13 dbSNP
rs1351630778 15 dbSNP
rs1034879562 18 dbSNP
rs1383267208 21 dbSNP
Putative Targets

Gene Information
Gene Symbol ZNF134   
Synonyms pHZ-15
Description zinc finger protein 134
Transcript NM_003435   
Expression
Putative miRNA Targets on ZNF134
3'UTR of ZNF134
(miRNA target sites are highlighted)		 
>ZNF134|NM_003435|3'UTR
   1 GAGTGCTTTGAATACAACAGGACTCATCAATCAGATGTTGAATTTCATGTATCTGAACATTGACACAAAGGAGATACCTT
  81 ATGGTGCCAGGTACGTGGGAACCTTCTAGGGATATGTTGCACTTTCTGACTTGCTCAGGTTTTTTGCCAGAGTTATGTCA
 161 CTGTCAATCCATGTGGCCGAAACCATCTTAACTCTACCAGCTAAGATACCCCAGCATTGGGGAAGGCAGGGTTTTGTATT
 241 GTCCAGTCCCTGGAGAAAATCATGAAATGCCTGAGTTCATTGGGGGTCCTCATTCCCTTCTGTATGACAGGTATAGGTAT
 321 GGATATGACCCATTTTTAGCCAAGAGGGTCTGAGCTGTATCTGCTGGTGGCTTATACAAAAAGTTTACTTTCTTCATGGA
 401 TATTCTTGGTCTCACATACTTGTAATCAAGTTTTTCCAGCCTCCAAGTCACCTGGCCTGGGAAAGTACTTGCCTCATGTT
 481 GCTCTGGTTTGTGATAATAAAGGCTTTACAGTTTAAGCCACATTTAATCTTGGGGCTTCTTCTTATGGTCTGGGGTGGAT
 561 TGAAAACAGGCTCTGCCAAACTGAAGACAGCCTTTGTGCGGTGCCTCCAACTTTGCCTCAAATGGGACAGTGGGTTGAGG
 641 GAGAACAGTTCTTAGTCCAGTTTTGATGTTAACTTCCATAGCTGACAAAGCTTGTTAAGTAAGAATTAAGATCTTGTGTA
 721 GACCTGATTTGTCTGGATTTTAGAGTTATTTGAGAGCCCATATTTCACCTTGAGGAGGGTGCTGCTGCTGTGACAGCCTG
 801 CAGTGTTTTGAAACAGCATGGATTGGGTGTCTTGTTTGCAGCATGTGTCCCATGTTCCCCAACACTGTTGAGGGAAAGCT
 881 GTTCCTCAGGACCTGCTGAGTGGCCATATTCCCTGAAGGCCTGAATCTGTTTCACAGGCCACTGTTGGTAAGATCTAAAG
 961 CATCCAGTAGGGAAACAAAATTGATAAATATTGAGTGTGAGTAATTGGGATTGGGGAGATTGTGGCAAACTAGAGGGGAA
1041 GTGCCCATTGTAAAAACACATCCACAGACAGTCCAGGCACTAAGGCTGAATGGGATCAGGGTATCCAGAAATCTCAGGAT
1121 CTCCAGGGCCATGTTACTGTTAGGTCAAGGTCACTGGTGCAGCAACGAATGTAGTTTTTCTAGATTCCTCTCCCTCCCTG
1201 GGCTCTTTACCTAATGTCTTTGCGGCACAGGCGGTAACCCTGGGAGTAAAGAGGTGTGGTCCAAGGAAGTAGCTTTTGTG
1281 ACCAGCTGGAGTTTCTGGTGACTCTTTTGGCAATGGTCCTCATTGTTTGCCAGTTTTTCTTACTACTGAGGAAGAGATTG
1361 TCTTCCCAAGATATTTGGAGTGATAAGAGTCACCATAGTGAGGTAGAGTCACTCTTAGTGATGTCCAGTTGTCCAGTTTC
1441 CAATAGAAGTGGGAGATCCAGATTTTTAAATGGGATAACTTTTTATAGGTTCACTGAGGTGTAATCAACATGCAATATAT
1521 TGCACATATTTAAAGTGTACGAGTTAAGTCTTGATACACACACACACACACACACACACACACACACACACACTTGAAAC
1601 TATCACCCTATCAGTGGTATTGGACATATCTGTTACCCCCAAAGTTAACCTGAGGCCCTTAACCTTTCTCTCAGTGCTCG
1681 CCTTCCCCCAGAATCCCTAGGCAACCACTGAGTAGTTTTCACTGTAGGTAAATTTGTCTTTTCTAGAATTTTATGTAAGT
1761 CTGCCTATAAAGTGTTAATTTTGCATGCTGTCTTTCATGCAACATAATTTGAAATTTGTCCATGGTATGTATGAACAGTC
1841 CATTTTAAAATTACTGAGTCATATTCTGTATGGATATACCACAGTTTATCCATTTATCTTAATTGATGTCTGTACTCCAC
1921 CCCCATTTTTAAATATTAAAAAGCTGCTGCAAATATTGATGCATGAGTCTTTATGTGGACACTTAGCTGAGAACATTTTT
2001 AAGCAGAGGTTTTGAAGGTGTGACCATATATCTTACTAATTATAGTAAAATATATTGGAAAAGAGATACATACAGGGAAG
2081 AACTGTGAAACAGAAAAGACCTAAGATTTGATGATTTGGGAAATTCTCAGCCCATCTTAATTGGAAAAAAAAAACAAACC
2161 ATTGAAATTAAGAGATTCATTGTTAGGAAAGATAGATGTTTTAGAGAGAGAGATGTTTTAGAGAGATAGCCAAGGATGTT
2241 TGCTGATACCGGGATCAAAACATACATCAGAACACTGTCACACAAAAAGCTCTTTGAAGAGATTAAATGTGACTTGTAGA
2321 TCCCCTCAATACAAACAATTTATAAGAAGTTTAAACTATCACTCATCTCAGCAAAAGCCAAAAATATAGATAGGGGATTC
2401 CCTAGGAGGAATAATCTGCATAAACCTCTTTTCTAATGTTGTGAATTTCAGTGATGTACAGGAGACTCACAAAATTCTTG
2481 AAAATTTTATACCAGTGGAAATGCTCACCTTGGGTCTAAAGGGACCTTGAAAGTATGAAGTTAAAGGGTGTAGGCATGTA
2561 AAGTGTGAAGTTAAAGGTTGTAATATTCTATACATGGGACTGGCTGCGGAAACAGGTGCAAGCCCTTGCTACCTTTCATG
2641 AGAAAGGAAGGATGACTCAGAGCAGAGGAGAGTCCAGTGGGCAGAGTCCTGAACCATGTGATATTCCCATGTCTTGACTC
2721 CCAGTGGCATTTGCCAAACTAGATTTCAGATTTTCTTGGGATTGGTGGTTCCATTTTTTTTGTTTTCCCCCCTTCCATTT
2801 CCTCCCCTTTTGAAACAATGCATATACATATAACTATTATCCTAGGTCTTTCCCAACCTTTTGTTTGGGAGCAGATAACT
2881 AGTTTTCTAGTTTTACAGATCCAAATGAGACAGGAATAGCACTGGGTGGTCACAGGAGGATGGAAAATCTCAACACCCTG
2961 GTTTTGGTGCAGCTGAAAAAAAAAAAGAAAAACCCAAACAACAGCTAAAACGGGAACTAGGCAAAGAAACCGTGGGATAA
3041 CAGAAAACCCAAAACAAAAGAGAAAACTGCCAGAACCCCAGTCAGGGTGACATGTCTGTAACTCTTCCAGGCAAACCCAA
3121 ATAAGGGAGGAGGGGTGGTAATCAGGGGTCCCTGAAATCCCCTCTTTTCCCAGAATACCTAATGATTACCCCTATTAAAG
3201 GAACACCCATACAATTAGAAACCCAAACTTTGTTTTGCATGACTTGCTCTCAGGGGCACTCCCACACTTCTCTCTTGTGT
3281 GTACTTTTGCTTCACAATAAAAGCTGCTTGCCTT
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' ccGUAUGUUAGACUGUACAua 5'
            ||  ||:  ||||||||  
Target 5' ccCAGTCAGGGTGACATGTct 3'
 3077 - 3097 139.00 -11.70
2 
miRNA  3' ccGUAUGUUAGA-CUGUACAUa 5'
            :| | ::| | |:|||||| 
Target 5' gtTAAAGGGTGTAGGCATGTAa 3'
 2540 - 2561 135.00 -8.60
3 
miRNA  3' ccgUAUGUUAGACUGUACAUa 5'
             ||  ||| |||| |||| 
Target 5' gagATTAAATGTGACTTGTAg 3'
 2299 - 2319 134.00 -8.00
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30494650 12 COSMIC
COSN30190928 24 COSMIC
COSN31511947 31 COSMIC
COSN26764245 35 COSMIC
COSN13839592 47 COSMIC
COSN30552298 48 COSMIC
COSN30170427 54 COSMIC
COSN30506183 56 COSMIC
COSN31572356 95 COSMIC
COSN30523676 96 COSMIC
COSN30488222 104 COSMIC
COSN31593147 107 COSMIC
COSN31612100 111 COSMIC
COSN512227 112 COSMIC
COSN20062570 142 COSMIC
COSN30114956 144 COSMIC
COSN30452446 171 COSMIC
COSN30760385 179 COSMIC
COSN30723465 180 COSMIC
COSN30507590 239 COSMIC
COSN21124522 251 COSMIC
COSN31598878 270 COSMIC
COSN15570884 466 COSMIC
COSN29432153 467 COSMIC
COSN17037497 485 COSMIC
COSN17037498 530 COSMIC
COSN17037499 543 COSMIC
COSN32160508 753 COSMIC
COSN2529478 1593 COSMIC
COSN29561278 2155 COSMIC
COSN16157553 2177 COSMIC
COSN24899379 2246 COSMIC
COSN5124849 2320 COSMIC
COSN5124850 2390 COSMIC
COSN17809641 2419 COSMIC
COSN9852862 2792 COSMIC
COSN27684899 3097 COSMIC
COSN22813761 3190 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs778725512 4 dbSNP
rs745578522 7 dbSNP
rs200517903 11 dbSNP
rs1339764108 13 dbSNP
rs1204214195 14 dbSNP
rs769310216 16 dbSNP
rs372685936 17 dbSNP
rs752642909 26 dbSNP
rs1395655273 27 dbSNP
rs758321267 30 dbSNP
rs763558127 31 dbSNP
rs1195928695 37 dbSNP
rs1371892622 39 dbSNP
rs751099887 49 dbSNP
rs922171636 51 dbSNP
rs1174683794 52 dbSNP
rs375727806 57 dbSNP
rs975750495 58 dbSNP
rs1433103266 61 dbSNP
rs780838743 62 dbSNP
rs1182178060 63 dbSNP
rs1385727930 64 dbSNP
rs576149012 65 dbSNP
rs1297581351 66 dbSNP
rs542156002 72 dbSNP
rs780370549 74 dbSNP
rs749809210 76 dbSNP
rs769229332 78 dbSNP
rs1302560514 80 dbSNP
rs775049555 81 dbSNP
rs774682981 86 dbSNP
rs1255103880 87 dbSNP
rs1485891571 89 dbSNP
rs1206412237 92 dbSNP
rs748266120 94 dbSNP
rs561840396 95 dbSNP
rs527543951 96 dbSNP
rs760973729 103 dbSNP
rs769751164 108 dbSNP
rs546608813 109 dbSNP
rs771704176 110 dbSNP
rs1455366002 112 dbSNP
rs953363020 116 dbSNP
rs1287203703 117 dbSNP
rs762603953 121 dbSNP
rs866031236 122 dbSNP
rs370943653 129 dbSNP
rs373444565 132 dbSNP
rs761373322 134 dbSNP
rs1413685624 136 dbSNP
rs767014001 137 dbSNP
rs532501786 138 dbSNP
rs755742262 140 dbSNP
rs779524837 141 dbSNP
rs1158990980 142 dbSNP
rs1228284674 152 dbSNP
rs1471038516 172 dbSNP
rs867854944 177 dbSNP
rs186505474 179 dbSNP
rs569153292 180 dbSNP
rs1259744677 184 dbSNP
rs533388416 187 dbSNP
rs747250891 191 dbSNP
rs1446987246 192 dbSNP
rs920773926 204 dbSNP
rs1207299971 205 dbSNP
rs1051515890 215 dbSNP
rs1053662941 218 dbSNP
rs895062960 220 dbSNP
rs538056580 223 dbSNP
rs548721564 239 dbSNP
rs1215372122 242 dbSNP
rs1012065921 246 dbSNP
rs749631532 250 dbSNP
rs905482094 263 dbSNP
rs1318858278 271 dbSNP
rs774903924 272 dbSNP
rs939595892 277 dbSNP
rs1056083806 280 dbSNP
rs1163898778 280 dbSNP
rs1462171966 281 dbSNP
rs1175636495 289 dbSNP
rs1420270377 291 dbSNP
rs1191652528 301 dbSNP
rs892111277 309 dbSNP
rs576600180 310 dbSNP
rs1195973057 313 dbSNP
rs970946643 320 dbSNP
rs1042102 326 dbSNP
rs770227314 328 dbSNP
rs1252798620 329 dbSNP
rs773556583 333 dbSNP
rs1214653021 335 dbSNP
rs903694164 336 dbSNP
rs568674568 344 dbSNP
rs963446027 345 dbSNP
rs973400082 349 dbSNP
rs763238578 350 dbSNP
rs1338163688 358 dbSNP
rs868121055 388 dbSNP
rs1028572903 390 dbSNP
rs1162112200 397 dbSNP
rs1391919438 398 dbSNP
rs953596932 410 dbSNP
rs1382435601 416 dbSNP
rs190036746 423 dbSNP
rs553831917 425 dbSNP
rs766787164 436 dbSNP
rs774551502 437 dbSNP
rs962009480 441 dbSNP
rs570446803 443 dbSNP
rs1316776802 444 dbSNP
rs1328293818 454 dbSNP
rs1477339245 459 dbSNP
rs1394982333 465 dbSNP
rs1194695946 466 dbSNP
rs936378630 469 dbSNP
rs1053373634 472 dbSNP
rs10403536 473 dbSNP
rs115775338 477 dbSNP
rs182974945 482 dbSNP
rs1215793820 483 dbSNP
rs1345697657 494 dbSNP
rs1235312581 499 dbSNP
rs1234828123 500 dbSNP
rs555654186 504 dbSNP
rs980996168 512 dbSNP
rs926778227 519 dbSNP
rs1355284567 520 dbSNP
rs541671079 533 dbSNP
rs555505751 534 dbSNP
rs1174797924 536 dbSNP
rs1375439204 536 dbSNP
rs572275072 539 dbSNP
rs906376778 540 dbSNP
rs1005117666 546 dbSNP
rs1263839028 547 dbSNP
rs1056616303 549 dbSNP
rs1015050590 553 dbSNP
rs1206093957 569 dbSNP
rs899231492 576 dbSNP
rs1186278532 577 dbSNP
rs945010938 579 dbSNP
rs1414992555 581 dbSNP
rs1475997325 593 dbSNP
rs1165147758 600 dbSNP
rs567212752 601 dbSNP
rs559496247 602 dbSNP
rs953333609 604 dbSNP
rs1374382246 610 dbSNP
rs560152579 615 dbSNP
rs1287475994 621 dbSNP
rs1413073192 622 dbSNP
rs1374937455 625 dbSNP
rs1387861953 626 dbSNP
rs753615009 648 dbSNP
rs1437154302 653 dbSNP
rs1049610707 655 dbSNP
rs1312371033 657 dbSNP
rs1401651446 667 dbSNP
rs1408341217 671 dbSNP
rs1183918208 676 dbSNP
rs1353598516 693 dbSNP
rs879487563 693 dbSNP
rs1416857400 694 dbSNP
rs1473984367 694 dbSNP
rs1256234748 698 dbSNP
rs890945922 717 dbSNP
rs1294069371 718 dbSNP
rs532366839 719 dbSNP
rs1019581299 723 dbSNP
rs1236700129 729 dbSNP
rs528692714 732 dbSNP
rs967605292 750 dbSNP
rs977989122 752 dbSNP
rs545743865 753 dbSNP
rs78225665 757 dbSNP
rs145105176 761 dbSNP
rs1294004610 770 dbSNP
rs1416671667 772 dbSNP
rs778922185 774 dbSNP
rs1188238027 775 dbSNP
rs1288787449 780 dbSNP
rs1432040460 809 dbSNP
rs1347324900 811 dbSNP
rs745485697 816 dbSNP
rs1459568706 824 dbSNP
rs1416688455 825 dbSNP
rs1416939529 825 dbSNP
rs1425037288 832 dbSNP
rs572715153 832 dbSNP
rs375184866 835 dbSNP
rs1454789835 840 dbSNP
rs80075511 844 dbSNP
rs1046346373 845 dbSNP
rs1373721391 855 dbSNP
rs952188930 857 dbSNP
rs981244965 862 dbSNP
rs568616982 863 dbSNP
rs1436723717 865 dbSNP
rs779569364 866 dbSNP
rs1235282885 867 dbSNP
rs1372920742 868 dbSNP
rs1389868849 869 dbSNP
rs960833959 878 dbSNP
rs376829858 888 dbSNP
rs1036590780 895 dbSNP
rs898968514 902 dbSNP
rs187446163 904 dbSNP
rs1278031010 921 dbSNP
rs1393360255 926 dbSNP
rs1326151373 930 dbSNP
rs994939088 934 dbSNP
rs1370847911 953 dbSNP
rs1169081185 954 dbSNP
rs1029041055 959 dbSNP
rs1429068401 961 dbSNP
rs1391920622 962 dbSNP
rs945618716 963 dbSNP
rs1467859884 968 dbSNP
rs1253337548 972 dbSNP
rs1043433260 983 dbSNP
rs1250853435 989 dbSNP
rs746533909 992 dbSNP
rs1349951208 993 dbSNP
rs1009304629 1007 dbSNP
rs1211067776 1023 dbSNP
rs1273246858 1026 dbSNP
rs1234092340 1027 dbSNP
rs1372197047 1029 dbSNP
rs1019232166 1031 dbSNP
rs770276723 1033 dbSNP
rs1388181539 1035 dbSNP
rs1178532411 1037 dbSNP
rs541395296 1043 dbSNP
rs1419986443 1046 dbSNP
rs1193385433 1048 dbSNP
rs932443222 1051 dbSNP
rs1453656630 1052 dbSNP
rs1437091246 1053 dbSNP
rs1395495841 1058 dbSNP
rs1049921005 1061 dbSNP
rs1417611374 1063 dbSNP
rs1250046067 1076 dbSNP
rs1174392906 1080 dbSNP
rs1033160197 1084 dbSNP
rs1210802618 1088 dbSNP
rs1349179569 1091 dbSNP
rs1306108859 1102 dbSNP
rs1237303896 1118 dbSNP
rs1008023969 1120 dbSNP
rs1300047420 1144 dbSNP
rs1391554276 1145 dbSNP
rs1351808901 1147 dbSNP
rs957497089 1151 dbSNP
rs989198116 1158 dbSNP
rs916326376 1167 dbSNP
rs548101255 1168 dbSNP
rs982167900 1170 dbSNP
rs147171300 1171 dbSNP
rs1363499317 1172 dbSNP
rs766283181 1179 dbSNP
rs539445331 1189 dbSNP
rs995814648 1192 dbSNP
rs1473657238 1197 dbSNP
rs556157413 1199 dbSNP
rs1027676679 1203 dbSNP
rs1187249815 1204 dbSNP
rs940615663 1209 dbSNP
rs1486311346 1212 dbSNP
rs1281305570 1218 dbSNP
rs139455711 1224 dbSNP
rs369424695 1225 dbSNP
rs1228664064 1230 dbSNP
rs898999522 1233 dbSNP
rs149674382 1234 dbSNP
rs540971293 1240 dbSNP
rs749856570 1241 dbSNP
rs1336077789 1244 dbSNP
rs1487950821 1246 dbSNP
rs1050533768 1247 dbSNP
rs1380398984 1247 dbSNP
rs889201596 1249 dbSNP
rs1213501301 1250 dbSNP
rs145864813 1252 dbSNP
rs914065160 1254 dbSNP
rs967015860 1257 dbSNP
rs1455985678 1262 dbSNP
rs1194762542 1264 dbSNP
rs1040763812 1268 dbSNP
rs1164349764 1268 dbSNP
rs903161980 1269 dbSNP
rs999516964 1273 dbSNP
rs1191674741 1274 dbSNP
rs548512858 1285 dbSNP
rs1262898054 1289 dbSNP
rs759705114 1294 dbSNP
rs1172608116 1302 dbSNP
rs957569163 1309 dbSNP
rs932274335 1314 dbSNP
rs1232213320 1315 dbSNP
rs1013038374 1317 dbSNP
rs1285380573 1321 dbSNP
rs1373924044 1325 dbSNP
rs767756111 1332 dbSNP
rs1461092914 1333 dbSNP
rs969532843 1335 dbSNP
rs1321033696 1344 dbSNP
rs1436965580 1347 dbSNP
rs1325455158 1348 dbSNP
rs1007248692 1356 dbSNP
rs1416094982 1360 dbSNP
rs545807382 1369 dbSNP
rs532028522 1372 dbSNP
rs1166186036 1380 dbSNP
rs1323707661 1381 dbSNP
rs1374110149 1383 dbSNP
rs1190980566 1396 dbSNP
rs912354142 1400 dbSNP
rs943761281 1401 dbSNP
rs1036893510 1404 dbSNP
rs1288154312 1406 dbSNP
rs1359762674 1411 dbSNP
rs1193548050 1412 dbSNP
rs191942066 1413 dbSNP
rs896959668 1419 dbSNP
rs1215882279 1429 dbSNP
rs1368528178 1430 dbSNP
rs1302368019 1436 dbSNP
rs1295637072 1446 dbSNP
rs931263197 1450 dbSNP
rs1048757960 1471 dbSNP
rs981854353 1476 dbSNP
rs927636530 1493 dbSNP
rs2885007 1502 dbSNP
rs972397039 1510 dbSNP
rs896611751 1513 dbSNP
rs1013611873 1516 dbSNP
rs1271696669 1527 dbSNP
rs183274613 1533 dbSNP
rs1478179465 1536 dbSNP
rs1248060273 1537 dbSNP
rs376913113 1541 dbSNP
rs188870447 1542 dbSNP
rs1207251762 1551 dbSNP
rs1219559138 1554 dbSNP
rs1279407854 1554 dbSNP
rs1345587651 1554 dbSNP
rs10589612 1556 dbSNP
rs1175131025 1556 dbSNP
rs1210628656 1556 dbSNP
rs1256717577 1556 dbSNP
rs1313753839 1556 dbSNP
rs1426897183 1556 dbSNP
rs1427482888 1556 dbSNP
rs146286553 1556 dbSNP
rs3054108 1556 dbSNP
rs35011458 1556 dbSNP
rs367609266 1556 dbSNP
rs376413721 1556 dbSNP
rs55784402 1556 dbSNP
rs59384400 1556 dbSNP
rs60608069 1556 dbSNP
rs68017833 1556 dbSNP
rs763676781 1556 dbSNP
rs1281804316 1558 dbSNP
rs1242107019 1559 dbSNP
rs1485177794 1561 dbSNP
rs1223462141 1562 dbSNP
rs1290345040 1568 dbSNP
rs1188402579 1585 dbSNP
rs761269173 1585 dbSNP
rs777409400 1585 dbSNP
rs1420294794 1587 dbSNP
rs979722566 1587 dbSNP
rs1355456663 1588 dbSNP
rs867574393 1589 dbSNP
rs1303918147 1590 dbSNP
rs1475018696 1592 dbSNP
rs1491406359 1593 dbSNP
rs910667204 1593 dbSNP
rs1491137127 1594 dbSNP
rs1032966762 1595 dbSNP
rs1412217316 1603 dbSNP
rs1160833600 1607 dbSNP
rs954316508 1608 dbSNP
rs527885978 1611 dbSNP
rs148596510 1618 dbSNP
rs903190732 1620 dbSNP
rs998860069 1630 dbSNP
rs1054675796 1633 dbSNP
rs912217891 1636 dbSNP
rs893373695 1637 dbSNP
rs114352426 1638 dbSNP
rs1231588182 1639 dbSNP
rs533635671 1640 dbSNP
rs1432782124 1641 dbSNP
rs1023103869 1643 dbSNP
rs971564166 1647 dbSNP
rs918438968 1656 dbSNP
rs1360467880 1658 dbSNP
rs1412545229 1664 dbSNP
rs1436278426 1665 dbSNP
rs1294685415 1667 dbSNP
rs1003705254 1668 dbSNP
rs1459485647 1677 dbSNP
rs1367417240 1678 dbSNP
rs1164808225 1679 dbSNP
rs760685765 1680 dbSNP
rs1048312246 1681 dbSNP
rs1187771171 1689 dbSNP
rs905816348 1690 dbSNP
rs1249597749 1706 dbSNP
rs962046800 1709 dbSNP
rs937254876 1711 dbSNP
rs1055078388 1713 dbSNP
rs1223827539 1715 dbSNP
rs144518114 1725 dbSNP
rs117427775 1729 dbSNP
rs951928813 1731 dbSNP
rs986016735 1739 dbSNP
rs1301655289 1744 dbSNP
rs1389537159 1746 dbSNP
rs1293647027 1760 dbSNP
rs1458990143 1769 dbSNP
rs1020967088 1783 dbSNP
rs776109598 1785 dbSNP
rs1001479425 1786 dbSNP
rs1430250830 1788 dbSNP
rs910380964 1797 dbSNP
rs1391812715 1800 dbSNP
rs146593158 1805 dbSNP
rs753715329 1817 dbSNP
rs1432863636 1826 dbSNP
rs1268316013 1828 dbSNP
rs924717821 1830 dbSNP
rs934684416 1832 dbSNP
rs1263999937 1833 dbSNP
rs1054374974 1843 dbSNP
rs1206543216 1852 dbSNP
rs1272206473 1853 dbSNP
rs985689544 1858 dbSNP
rs1485350422 1860 dbSNP
rs1185879026 1863 dbSNP
rs1330217720 1869 dbSNP
rs531261537 1871 dbSNP
rs948989744 1873 dbSNP
rs1044585210 1878 dbSNP
rs1306826137 1893 dbSNP
rs1430353862 1918 dbSNP
rs1475639491 1920 dbSNP
rs1176453812 1928 dbSNP
rs549057611 1931 dbSNP
rs907370271 1937 dbSNP
rs918294116 1953 dbSNP
rs1402407405 1960 dbSNP
rs1159660320 1964 dbSNP
rs548383942 1966 dbSNP
rs952493925 1968 dbSNP
rs1417515687 1970 dbSNP
rs1035221870 1974 dbSNP
rs1314175312 1975 dbSNP
rs1256017804 1980 dbSNP
rs927138295 1986 dbSNP
rs1441001965 1988 dbSNP
rs937283020 2000 dbSNP
rs1279365767 2006 dbSNP
rs1371541969 2009 dbSNP
rs897554928 2017 dbSNP
rs565591416 2019 dbSNP
rs534515890 2026 dbSNP
rs1352324942 2027 dbSNP
rs993190432 2032 dbSNP
rs1402683170 2035 dbSNP
rs1027335239 2040 dbSNP
rs1304322675 2041 dbSNP
rs1451960642 2043 dbSNP
rs1411472860 2044 dbSNP
rs1287431408 2047 dbSNP
rs917931024 2050 dbSNP
rs1473605686 2054 dbSNP
rs1415694745 2055 dbSNP
rs951654052 2064 dbSNP
rs986054827 2067 dbSNP
rs1017514584 2073 dbSNP
rs1042388452 2078 dbSNP
rs557494373 2084 dbSNP
rs966311654 2088 dbSNP
rs1203729101 2092 dbSNP
rs1463298370 2107 dbSNP
rs1267089505 2123 dbSNP
rs1208869069 2125 dbSNP
rs141358343 2129 dbSNP
rs192513105 2143 dbSNP
rs1000943843 2145 dbSNP
rs1054385848 2145 dbSNP
rs1281883975 2145 dbSNP
rs1443236902 2152 dbSNP
rs1380305211 2154 dbSNP
rs1388251095 2154 dbSNP
rs1007158959 2155 dbSNP
rs924721548 2155 dbSNP
rs934760237 2156 dbSNP
rs990171880 2157 dbSNP
rs1473438845 2159 dbSNP
rs914575910 2166 dbSNP
rs1181310326 2171 dbSNP
rs1449259193 2175 dbSNP
rs556348209 2177 dbSNP
rs1045074400 2180 dbSNP
rs1287190417 2182 dbSNP
rs1471006973 2188 dbSNP
rs1208696980 2194 dbSNP
rs1357051450 2196 dbSNP
rs1179010486 2198 dbSNP
rs1394477256 2199 dbSNP
rs1452469617 2203 dbSNP
rs1175032184 2206 dbSNP
rs370191062 2217 dbSNP
rs907447109 2219 dbSNP
rs1329539233 2220 dbSNP
rs1409046023 2228 dbSNP
rs1025303154 2230 dbSNP
rs1326375080 2231 dbSNP
rs938871771 2232 dbSNP
rs1444894371 2237 dbSNP
rs1166669453 2245 dbSNP
rs1310407840 2250 dbSNP
rs1429631038 2251 dbSNP
rs1037188536 2252 dbSNP
rs952602243 2254 dbSNP
rs1450991839 2255 dbSNP
rs1305758446 2262 dbSNP
rs897284882 2265 dbSNP
rs1345726222 2279 dbSNP
rs993263895 2280 dbSNP
rs1195457639 2283 dbSNP
rs1451686219 2284 dbSNP
rs927137904 2284 dbSNP
rs568126233 2288 dbSNP
rs992713243 2290 dbSNP
rs1275148055 2293 dbSNP
rs917202580 2293 dbSNP
rs887476630 2308 dbSNP
rs1007230661 2317 dbSNP
rs1274500987 2318 dbSNP
rs1437377021 2321 dbSNP
rs1332939179 2322 dbSNP
rs1306206526 2323 dbSNP
rs1199084474 2325 dbSNP
rs576491036 2326 dbSNP
rs965978692 2330 dbSNP
rs1433236440 2331 dbSNP
rs1424826562 2334 dbSNP
rs541809927 2335 dbSNP
rs1377724701 2339 dbSNP
rs1247967010 2340 dbSNP
rs374452549 2342 dbSNP
rs201665629 2344 dbSNP
rs776364344 2348 dbSNP
rs1482710379 2349 dbSNP
rs758087268 2351 dbSNP
rs1421294233 2352 dbSNP
rs1207103214 2356 dbSNP
rs1410171864 2360 dbSNP
rs889964153 2361 dbSNP
rs1220057064 2371 dbSNP
rs376438080 2381 dbSNP
rs1394121300 2387 dbSNP
rs1347370612 2391 dbSNP
rs955832855 2392 dbSNP
rs1439380860 2397 dbSNP
rs145046260 2412 dbSNP
rs1227859275 2416 dbSNP
rs527462431 2425 dbSNP
rs1351711892 2427 dbSNP
rs914649437 2436 dbSNP
rs769691646 2437 dbSNP
rs948759381 2439 dbSNP
rs1358977439 2442 dbSNP
rs184437885 2452 dbSNP
rs1414731609 2454 dbSNP
rs779584214 2457 dbSNP
rs746730864 2458 dbSNP
rs1037665040 2461 dbSNP
rs1025758444 2469 dbSNP
rs918767135 2478 dbSNP
rs1184300519 2479 dbSNP
rs547401001 2492 dbSNP
rs888096508 2493 dbSNP
rs1210526804 2495 dbSNP
rs931462387 2498 dbSNP
rs1444417939 2515 dbSNP
rs148433652 2518 dbSNP
rs1208286974 2526 dbSNP
rs1329935644 2533 dbSNP
rs539882980 2535 dbSNP
rs1227124800 2536 dbSNP
rs1379048239 2544 dbSNP
rs1285198100 2546 dbSNP
rs958535394 2552 dbSNP
rs1268024623 2553 dbSNP
rs992653242 2555 dbSNP
rs112605143 2559 dbSNP
rs1024079420 2561 dbSNP
rs1456344954 2577 dbSNP
rs9749439 2579 dbSNP
rs1243287423 2586 dbSNP
rs1477946568 2590 dbSNP
rs1182296358 2591 dbSNP
rs1163711306 2595 dbSNP
rs1473664961 2596 dbSNP
rs111371772 2608 dbSNP
rs191709772 2609 dbSNP
rs1165330460 2611 dbSNP
rs1038712103 2621 dbSNP
rs1465472252 2628 dbSNP
rs184061386 2631 dbSNP
rs936649383 2632 dbSNP
rs759834849 2634 dbSNP
rs997447195 2641 dbSNP
rs1321714695 2644 dbSNP
rs1031971516 2645 dbSNP
rs1382141317 2648 dbSNP
rs774657534 2654 dbSNP
rs1230467549 2655 dbSNP
rs911348032 2659 dbSNP
rs1328204312 2661 dbSNP
rs1164278921 2663 dbSNP
rs1011359339 2667 dbSNP
rs1365434076 2670 dbSNP
rs942755673 2680 dbSNP
rs1455925110 2683 dbSNP
rs1021686074 2689 dbSNP
rs528982617 2705 dbSNP
rs746234647 2714 dbSNP
rs1234982880 2742 dbSNP
rs1450364324 2757 dbSNP
rs1264117085 2764 dbSNP
rs376101383 2766 dbSNP
rs1189604153 2768 dbSNP
rs901325325 2774 dbSNP
rs930241238 2774 dbSNP
rs1224460338 2775 dbSNP
rs980564940 2780 dbSNP
rs554029368 2781 dbSNP
rs1053164 2783 dbSNP
rs763010773 2787 dbSNP
rs928670404 2787 dbSNP
rs548847220 2788 dbSNP
rs565323209 2791 dbSNP
rs1342510704 2792 dbSNP
rs973043830 2793 dbSNP
rs75581532 2796 dbSNP
rs918840811 2797 dbSNP
rs1293550862 2800 dbSNP
rs931493357 2808 dbSNP
rs894256653 2820 dbSNP
rs1186577586 2823 dbSNP
rs772281832 2826 dbSNP
rs551234134 2827 dbSNP
rs1475980765 2829 dbSNP
rs911366278 2831 dbSNP
rs1174227356 2832 dbSNP
rs1190120243 2836 dbSNP
rs375125162 2837 dbSNP
rs1268207156 2841 dbSNP
rs1024110714 2842 dbSNP
rs1251715323 2857 dbSNP
rs775562758 2857 dbSNP
rs1039156157 2864 dbSNP
rs1481827945 2866 dbSNP
rs189144240 2870 dbSNP
rs113427134 2874 dbSNP
rs151281401 2879 dbSNP
rs1408764090 2883 dbSNP
rs1420432864 2885 dbSNP
rs1312350898 2895 dbSNP
rs957512381 2904 dbSNP
rs1307354526 2907 dbSNP
rs1348619684 2907 dbSNP
rs1416795770 2911 dbSNP
rs573799426 2913 dbSNP
rs1313168494 2920 dbSNP
rs1398403507 2925 dbSNP
rs140443984 2927 dbSNP
rs976811953 2929 dbSNP
rs570165986 2931 dbSNP
rs1471661137 2932 dbSNP
rs1411253033 2940 dbSNP
rs891693933 2941 dbSNP
rs181480396 2943 dbSNP
rs1021426772 2948 dbSNP
rs776903656 2949 dbSNP
rs1209611673 2951 dbSNP
rs1254570484 2960 dbSNP
rs888744158 2974 dbSNP
rs1228983550 2976 dbSNP
rs1287114276 2976 dbSNP
rs1326464071 2976 dbSNP
rs1468755010 2976 dbSNP
rs1482760489 2976 dbSNP
rs1337433428 2977 dbSNP
rs969840028 2979 dbSNP
rs1277553501 2980 dbSNP
rs1310397419 2982 dbSNP
rs1395225141 2984 dbSNP
rs1402577355 2997 dbSNP
rs761797598 3002 dbSNP
rs1001629097 3003 dbSNP
rs1036177241 3012 dbSNP
rs960107994 3013 dbSNP
rs1471463571 3027 dbSNP
rs894120853 3032 dbSNP
rs150412869 3033 dbSNP
rs1424771811 3053 dbSNP
rs1245280650 3054 dbSNP
rs1180072415 3058 dbSNP
rs1045421228 3059 dbSNP
rs903017076 3060 dbSNP
rs1382775835 3063 dbSNP
rs998737406 3063 dbSNP
rs1205203757 3075 dbSNP
rs1033249912 3076 dbSNP
rs138151289 3077 dbSNP
rs1173109529 3091 dbSNP
rs541456921 3108 dbSNP
rs765300494 3110 dbSNP
rs750178707 3113 dbSNP
rs1316835302 3116 dbSNP
rs187397403 3119 dbSNP
rs1364684900 3127 dbSNP
rs1321375232 3130 dbSNP
rs1402506089 3133 dbSNP
rs1388597361 3134 dbSNP
rs1163192714 3142 dbSNP
rs1458829052 3143 dbSNP
rs1387495378 3154 dbSNP
rs1167066768 3161 dbSNP
rs984350336 3162 dbSNP
rs535544529 3172 dbSNP
rs1311178580 3195 dbSNP
rs922672868 3207 dbSNP
rs578251599 3211 dbSNP
rs762826302 3227 dbSNP
rs1293718650 3229 dbSNP
rs982998748 3230 dbSNP
rs868507558 3236 dbSNP
rs974551325 3240 dbSNP
rs923011012 3241 dbSNP
rs1271002353 3242 dbSNP
rs1329446720 3244 dbSNP
rs933022661 3246 dbSNP
rs1300628404 3247 dbSNP
rs1052705072 3256 dbSNP
rs543810371 3260 dbSNP
rs1406145589 3276 dbSNP
rs1233544003 3277 dbSNP
rs1167166845 3279 dbSNP
rs563900031 3283 dbSNP
rs1250457359 3285 dbSNP
rs147015134 3287 dbSNP
rs542686960 3288 dbSNP
rs947324614 3292 dbSNP
rs754248126 3298 dbSNP
rs757792262 3299 dbSNP
rs1375480508 3310 dbSNP
rs559044355 3312 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions hESCs (WA-09)
Disease 7693.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in SRR359787. RNA binding protein: AGO2. Condition:4-thiouridine ...

- Lipchina I; Elkabetz Y; Hafner M; Sheridan et al., 2011, Genes & development.

Article - Lipchina I; Elkabetz Y; Hafner M; Sheridan et al.
- Genes & development, 2011
MicroRNAs are important regulators in many cellular processes, including stem cell self-renewal. Recent studies demonstrated their function as pluripotency factors with the capacity for somatic cell reprogramming. However, their role in human embryonic stem (ES) cells (hESCs) remains poorly understood, partially due to the lack of genome-wide strategies to identify their targets. Here, we performed comprehensive microRNA profiling in hESCs and in purified neural and mesenchymal derivatives. Using a combination of AGO cross-linking and microRNA perturbation experiments, together with computational prediction, we identified the targets of the miR-302/367 cluster, the most abundant microRNAs in hESCs. Functional studies identified novel roles of miR-302/367 in maintaining pluripotency and regulating hESC differentiation. We show that in addition to its role in TGF-beta signaling, miR-302/367 promotes bone morphogenetic protein (BMP) signaling by targeting BMP inhibitors TOB2, DAZAP2, and SLAIN1. This study broadens our understanding of microRNA function in hESCs and is a valuable resource for future studies in this area.
LinkOut: [PMID: 22012620]
CLIP-seq Support 1 for dataset SRR359787
Method / RBP PAR-CLIP / AGO2
Cell line / Condition hESCs (WA-09) / 4-thiouridine, RNase T1
Location of target site ENST00000396161.5 | 3UTR | AAGUGUGAAGUUAAAGGUUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22012620 / SRX103431
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
83 hsa-miR-4666a-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT057266 FAM35A family with sequence similarity 35 member A 2 2
MIRT059969 PATL1 PAT1 homolog 1, processing body mRNA decay factor 2 6
MIRT079031 TNRC6C trinucleotide repeat containing 6C 2 2
MIRT079631 DNAJB4 DnaJ heat shock protein family (Hsp40) member B4 2 2
MIRT086974 LANCL1 LanC like 1 2 2
MIRT091804 GOLGA4 golgin A4 2 2
MIRT229501 EIF1AX eukaryotic translation initiation factor 1A, X-linked 2 4
MIRT255972 WDR17 WD repeat domain 17 2 2
MIRT262975 ADO 2-aminoethanethiol dioxygenase 2 2
MIRT264774 PAFAH1B2 platelet activating factor acetylhydrolase 1b catalytic subunit 2 2 2
MIRT334169 CCND1 cyclin D1 2 6
MIRT345868 SRSF2 serine and arginine rich splicing factor 2 2 2
MIRT452477 DDX4 DEAD-box helicase 4 2 2
MIRT455764 TSPAN6 tetraspanin 6 2 4
MIRT461627 DCAF15 DDB1 and CUL4 associated factor 15 2 4
MIRT465169 TRPV2 transient receptor potential cation channel subfamily V member 2 2 4
MIRT468950 RPS14 ribosomal protein S14 2 6
MIRT483236 C2orf72 chromosome 2 open reading frame 72 2 8
MIRT498544 TMEM30B transmembrane protein 30B 2 2
MIRT500633 TXNIP thioredoxin interacting protein 2 4
MIRT504113 GPR158 G protein-coupled receptor 158 2 2
MIRT504428 ZNF85 zinc finger protein 85 2 6
MIRT505036 ZNF451 zinc finger protein 451 2 2
MIRT506526 MRPL17 mitochondrial ribosomal protein L17 2 6
MIRT508773 GSG1 germ cell associated 1 2 2
MIRT517297 ELF4 E74 like ETS transcription factor 4 2 6
MIRT519353 OBFC1 STN1, CST complex subunit 2 4
MIRT523891 ENPP6 ectonucleotide pyrophosphatase/phosphodiesterase 6 2 6
MIRT527509 ZNF134 zinc finger protein 134 2 2
MIRT531218 IFNGR2 interferon gamma receptor 2 2 2
MIRT535957 MOGAT1 monoacylglycerol O-acyltransferase 1 2 2
MIRT537229 GALNT7 polypeptide N-acetylgalactosaminyltransferase 7 2 4
MIRT537337 FKBP5 FK506 binding protein 5 2 2
MIRT539125 ARHGEF17 Rho guanine nucleotide exchange factor 17 2 2
MIRT539910 ISPD isoprenoid synthase domain containing 2 2
MIRT541527 MGAT4C MGAT4 family member C 2 2
MIRT546119 USP25 ubiquitin specific peptidase 25 2 2
MIRT548846 CERCAM cerebral endothelial cell adhesion molecule 2 2
MIRT549892 LINC00955 long intergenic non-protein coding RNA 955 2 2
MIRT549898 ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide 2 2
MIRT550763 ENOX2 ecto-NOX disulfide-thiol exchanger 2 2 4
MIRT553200 UBE2A ubiquitin conjugating enzyme E2 A 2 2
MIRT553970 SRSF10 serine and arginine rich splicing factor 10 2 2
MIRT554092 SMU1 DNA replication regulator and spliceosomal factor 2 2
MIRT555208 PROX1 prospero homeobox 1 2 4
MIRT555834 PAX5 paired box 5 2 4
MIRT556865 JAZF1 JAZF zinc finger 1 2 2
MIRT558594 CREBL2 cAMP responsive element binding protein like 2 2 2
MIRT559690 AGO2 argonaute 2, RISC catalytic component 2 4
MIRT563312 ORC4 origin recognition complex subunit 4 2 2
MIRT563585 FAM229B family with sequence similarity 229 member B 2 2
MIRT563853 ALYREF Aly/REF export factor 2 4
MIRT565146 TUBB2A tubulin beta 2A class IIa 2 2
MIRT565769 SEPHS1 selenophosphate synthetase 1 2 2
MIRT568317 BACH1 BTB domain and CNC homolog 1 2 2
MIRT575387 Unc5b unc-5 netrin receptor B 2 4
MIRT607728 BDH1 3-hydroxybutyrate dehydrogenase 1 2 8
MIRT612691 PLXNA4 plexin A4 2 4
MIRT615916 GDPD1 glycerophosphodiester phosphodiesterase domain containing 1 2 2
MIRT629792 P2RY1 purinergic receptor P2Y1 2 2
MIRT632119 FKBP9 FK506 binding protein 9 2 2
MIRT645554 ZDHHC15 zinc finger DHHC-type containing 15 2 4
MIRT651479 WWC3 WWC family member 3 2 2
MIRT654138 RPH3A rabphilin 3A 2 6
MIRT655191 PHAX phosphorylated adaptor for RNA export 2 2
MIRT665543 UNC5B unc-5 netrin receptor B 2 5
MIRT668057 GRIK3 glutamate ionotropic receptor kainate type subunit 3 2 2
MIRT678978 CERS4 ceramide synthase 4 2 4
MIRT679124 RBM3 RNA binding motif (RNP1, RRM) protein 3 2 2
MIRT686776 AZF1 azoospermia factor 1 2 2
MIRT687144 PTPN12 protein tyrosine phosphatase, non-receptor type 12 2 2
MIRT691453 C21orf58 chromosome 21 open reading frame 58 2 2
MIRT691469 FAM98B family with sequence similarity 98 member B 2 2
MIRT697031 UHRF1BP1 UHRF1 binding protein 1 2 2
MIRT698401 TM9SF3 transmembrane 9 superfamily member 3 2 2
MIRT702056 RNMT RNA guanine-7 methyltransferase 2 2
MIRT705903 ADAM9 ADAM metallopeptidase domain 9 2 2
MIRT707491 MMADHC methylmalonic aciduria and homocystinuria, cblD type 2 2
MIRT708080 KLHL23 kelch like family member 23 2 2
MIRT709738 TRIM27 tripartite motif containing 27 2 2
MIRT710056 RWDD2A RWD domain containing 2A 2 2
MIRT710226 KCNK1 potassium two pore domain channel subfamily K member 1 2 2
MIRT712043 STYK1 serine/threonine/tyrosine kinase 1 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4666a Doxorubicin 31703 NSC123127 approved sensitive High Triple-Negative Breast Cancer cell line (MDA-MB-231, MDA-MB-468)

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