miRTarBase - #MIRT527562


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pre-miRNA Information
pre-miRNA hsa-mir-5590   
Genomic Coordinates chr2: 134857820 - 134857873
Description Homo sapiens miR-5590 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-5590-5p
Sequence 1| UUGCCAUACAUAGACUUUAUU |21
Evidence Not_experimental
Experiments
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs553031425 1 dbSNP
rs1255264134 4 dbSNP
rs1205476379 9 dbSNP
rs1387316331 10 dbSNP
rs1031241138 11 dbSNP
rs1465409255 12 dbSNP
rs1227248415 18 dbSNP
rs1334861447 19 dbSNP
Putative Targets

Gene Information
Gene Symbol ADCY7   
Synonyms AC7
Description adenylate cyclase 7
Transcript NM_001114   
Expression
Putative miRNA Targets on ADCY7
3'UTR of ADCY7
(miRNA target sites are highlighted)		 
>ADCY7|NM_001114|3'UTR
   1 GGGCTCCTGCTGGATTCCGAAAAGGCCGGGAAGCCAGTCTCCTTCCCTGAAGCAAGCCCAGGAGAAGACTCTCCGCCCCA
  81 CGCCAATCCCAAAGGCATGCAGATGGCTGTGCATGTTGGCTTCTTTGGACCTGCACTGGAGGATTTCTCAGACACATGCA
 161 CCAGATTCTGGCTCGAAGCAGCCACTGAGCCATAATGCGCAGGGGAGGCCAGAAGCTCTGTGCCTGGTCTGTAACAGTTT
 241 CCAGGCCAGCTGGAGAATGTTCACTGGTTCGGGGCTGACTTTGAGATCTTTGTTCCCTGAGGTGCCAGGCAGGCAACTTT
 321 AGCACATGATGAAAACAGACTTCCACCTCAGTGGCCTGTGGGCACGCACAAGTGAGGTCTGTTTTTCTAGACACCAAGGG
 401 GGAGTAAGCTGAGCTGTCTAGCACGGATTGGAGACTCCCTCTCCCTGGTGGGCCTGGCAATGACAGCATTTCTCACAGAG
 481 GCATTCTGGTAAATGAAGCTGAAAGGGGTGTTTTACATCTGTAAACGGTTTCAAACAGGTAGAGAGAAAAACACCACAAT
 561 TAACACTGTTACTTTTTGCCTTGTCTGGCATGTTTGTTTTAAATGAATACATTAATGGGGTTTTTATCCTTTTGAATGAC
 641 TTTTCAGACACTAGACATAAATCTCTTCCCTCCAGTGTATGCTCTGCCTTTTTAACCACTGACATGTAAGGAGGACTACT
 721 GTCTAGCATCAGCTTATGGGGTCAGCTGGCTGTGGGGATAGAGTCCTGAGGAATGTGGTCACAGCAAGAAGGCGGGGAGC
 801 AGCAGAGCCTTGCCTTTGAATGAGGCAGCTTGTGAGGCAAGCATTCTGGAGAGAGGTGCTTTGAAAGTAAGGTGCGGCCT
 881 TTCACCTCTTCCTTGATTACTCACACATCTTTGCGTTCTCCCCTGCCGTCCTTCAACTGTATCTTACTTTTCTTACCAGA
 961 AAGGAATGGAGTCTGTTTAGAGACAACTTGGACAACCTGTGAGTGCATCTCTTCTTTCCTTTAGTCTTCACAGCTAACTC
1041 TGGAGAGCTTCAAAACTAGAAGGATCTACTCCGCATGGGTGCATGCAGAGGCTCCTGGATCTGGGAAGCCCGCCCCCTCA
1121 CAAATGCTGAGCCGTTCTTGCTCTGAAACTGCGTGAGTCAAGGCAAATGCAAAAAGCCAGGTTTTGGGGATGTGTCTTAC
1201 TGTGCTTCAACTTCCCAAGGAATTGAAAGTCAACCTAACTGTAACAACAGGGTGAGAAATGACCAAACTGCCCGTGACTT
1281 TTTCTGAATGGACTTCATAACCGGAAGACTTAACCGGTGGCCTCATCACCAGAGCATCGCCAGGATTTCTAATGCACTCA
1361 GTTTCCCTACATAGCAGGGATTCTTAGCTAGGTGTCCCCATGAACCCCGTAAAGTTCTACACAAAGTCTTGCATACAGGA
1441 GCCTTTACAAGATGATTATACAGGGTTGCAGATTGGGTGACTGACCAGACTTGTTGGGGTCCTGGGATGAGTTGCCCCGG
1521 GCTGCAAATTAAGAGTACAGCTAAGTGCGGGGGTGGCGGTGGAGGGAACGAAAATTGAACCTGTCTGCCTGTGCTGTGTC
1601 GTGTGGCTTTATCAGCCCGAGGAAGGGCAGGTGTATTCTAATTTGCACAAAGGTGCTGGGTAGACTAGTGGCAGCTCTCA
1681 TGTGCTGCACATAAGTGGAATCAGTATGAATAGAAGAACTTGCTGTATAAAGGAATTTCATGGCAACAATGCTGGTAAGG
1761 GCAATTAGCCTCGCTTAAGTTGCCTTTTTTACACACCAAAACTTTTTACATGAAGGGCTGGTTTCACATGAATACTATAC
1841 TGAAATCTGTGCTCTCAAGATCTAGCAGTGACCAGGGCTGCCCGGCGGGGGCTCTCCTGGCAAGTCAGGAAGGTTTCTGT
1921 TGCTAATATAACATAGAAACACATTAGTGCACTGGGCCTCTCTGAGGTCAGCATATTTGTACTCTTGGAATATTTGTTTT
2001 TTTCTTCAGTAACAACAGAAACCCCAGTTGGGAGTTTAACAAATAACTGACTACCACTCACTCATGCATTTTTATTTCCA
2081 ATTAAAGCAAAGCACTGTGCTGTGCTCAGATAATAATAGTTTGTAAGTAAAAGTTTTTAGTTTTCAGTGTTCAGGTTATA
2161 GAATATAACTGACCATAAAAATTACCTGCAGGTATTTTCTTTTTATGAACTTGTTTTTAAATTACCAAGTAATTACTGGT
2241 GTCATTTTGTTTTATGACAGACACACGTATCTAACAAACAAACAAACAGTGACCTTCTCCATGGGTCAAGGACTTCCTTA
2321 CAATTTCTCCTGAGTTAACTTTTGTGAAAATAATACCTAAGGTTTTCTGGCTTATTGAGGAAATTTCCTAACAAACAAAC
2401 AAACAAACAAACAGAAGAGAAGATCATTAACCACTGTATACTTTGTGTATATAATAGGTCAGTGTAAAGAAATATGATTT
2481 GAGGTGGTGCATGCAAGTAACTAGGGTTTATTCTATATAATGAATATTTATAGATCTGTAACATTTGTTTCAAAATGCTG
2561 TTTCATTTTTATAAAGTACCAGTGTTTAGCTGCTTTTTATACATTAAATTAGCAATTTGAAAAACTCAAAAAAAAAAAAA
2641 AAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' uuAUUUCAGAUACA-UACCGUu 5'
            |||||   || | |||||| 
Target 5' taTAAAG-GAATTTCATGGCAa 3'
 1726 - 1746 126.00 -11.54
2 
miRNA  3' uuauuuCAGAUACAUACCGUu 5'
                | || ||| ||||| 
Target 5' ctttttGCCT-TGTCTGGCAt 3'
 572 - 591 122.00 -8.00
3 
miRNA  3' uuaUUUCA-GAUAC-----AU-ACCGUu 5'
             ||:|| ||: |     || ||||| 
Target 5' acaAAGGTGCTGGGTAGACTAGTGGCAg 3'
 1647 - 1674 118.00 -11.20
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN26965200 11 COSMIC
COSN30190216 20 COSMIC
COSN31494520 59 COSMIC
COSN30449673 65 COSMIC
COSN30497424 75 COSMIC
COSN30129885 108 COSMIC
COSN23270284 123 COSMIC
COSN1699527 229 COSMIC
COSN7259101 787 COSMIC
COSN9647458 818 COSMIC
COSN31961202 1085 COSMIC
COSN32062287 1284 COSMIC
COSN31585580 1571 COSMIC
COSN31593734 1604 COSMIC
COSN31485549 1607 COSMIC
COSN26576527 1646 COSMIC
COSN31538573 1672 COSMIC
COSN27773734 2196 COSMIC
COSN22353493 2294 COSMIC
COSN5407421 2318 COSMIC
COSN20112866 2411 COSMIC
COSN20112864 2414 COSMIC
rs1872691 795 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1349809992 4 dbSNP
rs1206786268 6 dbSNP
rs777811039 11 dbSNP
rs746983683 12 dbSNP
rs757389802 18 dbSNP
rs9940992 19 dbSNP
rs746073982 20 dbSNP
rs891707075 21 dbSNP
rs769992913 23 dbSNP
rs749618985 25 dbSNP
rs769042923 28 dbSNP
rs762360875 29 dbSNP
rs765864596 31 dbSNP
rs1407641272 35 dbSNP
rs1376102748 36 dbSNP
rs1035321841 40 dbSNP
rs776048333 51 dbSNP
rs541773351 54 dbSNP
rs1423025912 58 dbSNP
rs112368100 69 dbSNP
rs143913266 69 dbSNP
rs745618729 73 dbSNP
rs561790471 75 dbSNP
rs779414356 76 dbSNP
rs574378357 82 dbSNP
rs148478397 83 dbSNP
rs1033744340 95 dbSNP
rs959743411 96 dbSNP
rs1215677406 98 dbSNP
rs201343536 99 dbSNP
rs560422138 114 dbSNP
rs574453018 118 dbSNP
rs1184148384 132 dbSNP
rs1276732839 143 dbSNP
rs1366432711 145 dbSNP
rs532176249 152 dbSNP
rs985391048 160 dbSNP
rs992158027 162 dbSNP
rs1392299348 165 dbSNP
rs758737314 169 dbSNP
rs917956194 175 dbSNP
rs181634047 176 dbSNP
rs1172376637 191 dbSNP
rs60444957 199 dbSNP
rs923274936 201 dbSNP
rs1257840992 212 dbSNP
rs983672672 216 dbSNP
rs909479471 232 dbSNP
rs1306853543 234 dbSNP
rs777255583 236 dbSNP
rs988824889 239 dbSNP
rs1371781688 241 dbSNP
rs1457728088 242 dbSNP
rs531481525 244 dbSNP
rs1039635841 256 dbSNP
rs1235574904 256 dbSNP
rs947466579 265 dbSNP
rs921690308 266 dbSNP
rs933100739 271 dbSNP
rs1298854542 272 dbSNP
rs780310116 279 dbSNP
rs1399527438 280 dbSNP
rs1340182286 286 dbSNP
rs747438578 296 dbSNP
rs905665870 300 dbSNP
rs548199318 313 dbSNP
rs1163547688 321 dbSNP
rs1421716947 321 dbSNP
rs1245832363 323 dbSNP
rs1177322788 325 dbSNP
rs1457686633 329 dbSNP
rs1236954060 331 dbSNP
rs1215927621 333 dbSNP
rs866746292 342 dbSNP
rs1469141801 349 dbSNP
rs568097152 354 dbSNP
rs1219599611 357 dbSNP
rs112889509 366 dbSNP
rs548080841 367 dbSNP
rs1376062482 368 dbSNP
rs571139360 368 dbSNP
rs56232225 373 dbSNP
rs556719417 377 dbSNP
rs1275427960 378 dbSNP
rs1391129013 386 dbSNP
rs904466352 388 dbSNP
rs1001355651 396 dbSNP
rs1034624305 397 dbSNP
rs1346639969 398 dbSNP
rs1456041707 398 dbSNP
rs1158719206 409 dbSNP
rs1438603221 412 dbSNP
rs888205551 415 dbSNP
rs895222388 425 dbSNP
rs1016441248 426 dbSNP
rs576454100 429 dbSNP
rs535591293 442 dbSNP
rs1189893238 443 dbSNP
rs571903499 454 dbSNP
rs555323561 466 dbSNP
rs563372063 467 dbSNP
rs1187959872 474 dbSNP
rs759893247 491 dbSNP
rs1014124417 495 dbSNP
rs1216175560 502 dbSNP
rs1351510278 503 dbSNP
rs1025073634 520 dbSNP
rs1030627148 522 dbSNP
rs1331656001 523 dbSNP
rs755041568 527 dbSNP
rs572083674 528 dbSNP
rs1363619663 537 dbSNP
rs954964677 539 dbSNP
rs1358029243 541 dbSNP
rs1418720638 541 dbSNP
rs989232775 544 dbSNP
rs1466987384 551 dbSNP
rs1197199966 552 dbSNP
rs1377599564 552 dbSNP
rs1430729128 553 dbSNP
rs1369885193 556 dbSNP
rs116529321 558 dbSNP
rs1167483525 561 dbSNP
rs1487441851 567 dbSNP
rs778822977 571 dbSNP
rs1016508194 576 dbSNP
rs1345622615 581 dbSNP
rs560149181 586 dbSNP
rs927376264 590 dbSNP
rs1308969284 606 dbSNP
rs75831772 613 dbSNP
rs1401985983 617 dbSNP
rs762611555 617 dbSNP
rs1398956418 628 dbSNP
rs748308848 630 dbSNP
rs922134518 633 dbSNP
rs929879852 634 dbSNP
rs1402107779 635 dbSNP
rs1171265128 637 dbSNP
rs558099056 641 dbSNP
rs1424722116 658 dbSNP
rs1047186489 660 dbSNP
rs575276298 661 dbSNP
rs1188316655 666 dbSNP
rs1441854685 668 dbSNP
rs1254175278 675 dbSNP
rs1198621806 680 dbSNP
rs796159926 683 dbSNP
rs1258444593 685 dbSNP
rs1227938878 697 dbSNP
rs1217830261 701 dbSNP
rs1315681413 704 dbSNP
rs1294811858 705 dbSNP
rs987146653 706 dbSNP
rs1331647565 708 dbSNP
rs562745185 710 dbSNP
rs1298440075 711 dbSNP
rs1401710796 715 dbSNP
rs1331090042 722 dbSNP
rs1464444680 727 dbSNP
rs1420489273 733 dbSNP
rs945690394 737 dbSNP
rs1344345768 739 dbSNP
rs899580287 740 dbSNP
rs996369804 745 dbSNP
rs1472610351 747 dbSNP
rs1366744758 756 dbSNP
rs1184139534 759 dbSNP
rs769867359 762 dbSNP
rs1230558931 764 dbSNP
rs1197768909 768 dbSNP
rs1456238220 769 dbSNP
rs1291797133 773 dbSNP
rs1210008713 774 dbSNP
rs1042727362 777 dbSNP
rs1281890622 782 dbSNP
rs989038174 783 dbSNP
rs1378277534 785 dbSNP
rs1020712885 786 dbSNP
rs370643134 794 dbSNP
rs1872691 795 dbSNP
rs1324643446 800 dbSNP
rs1404966349 806 dbSNP
rs1388898293 813 dbSNP
rs1160371991 821 dbSNP
rs1258002536 824 dbSNP
rs1379783647 830 dbSNP
rs1177862737 833 dbSNP
rs1463269145 842 dbSNP
rs563983986 844 dbSNP
rs895596917 852 dbSNP
rs1014104358 854 dbSNP
rs1287367831 856 dbSNP
rs1218355001 864 dbSNP
rs1025042433 871 dbSNP
rs577269390 876 dbSNP
rs561788535 877 dbSNP
rs747308946 890 dbSNP
rs1373893019 893 dbSNP
rs1275781679 896 dbSNP
rs929884346 899 dbSNP
rs1329552310 902 dbSNP
rs1320473339 907 dbSNP
rs1420547360 909 dbSNP
rs1466994542 910 dbSNP
rs1156977833 911 dbSNP
rs1046939538 915 dbSNP
rs56018511 916 dbSNP
rs1386824621 918 dbSNP
rs1016308179 923 dbSNP
rs1477536955 926 dbSNP
rs1434674919 928 dbSNP
rs760607802 929 dbSNP
rs541438484 931 dbSNP
rs1488430623 934 dbSNP
rs975360135 937 dbSNP
rs1461235971 942 dbSNP
rs1438863083 943 dbSNP
rs1280029255 946 dbSNP
rs1314442591 946 dbSNP
rs899611694 947 dbSNP
rs777238833 955 dbSNP
rs1029254796 957 dbSNP
rs1052366165 970 dbSNP
rs1400807228 971 dbSNP
rs955013581 972 dbSNP
rs1296409451 979 dbSNP
rs890595925 984 dbSNP
rs1359820774 985 dbSNP
rs763837174 988 dbSNP
rs1334672148 989 dbSNP
rs1422752841 991 dbSNP
rs1172605424 993 dbSNP
rs1233795257 1000 dbSNP
rs1257560092 1002 dbSNP
rs1422547547 1010 dbSNP
rs1190868903 1012 dbSNP
rs1483906776 1017 dbSNP
rs1237560212 1021 dbSNP
rs1326760658 1032 dbSNP
rs1207753860 1034 dbSNP
rs987617004 1035 dbSNP
rs1020575816 1042 dbSNP
rs912963899 1044 dbSNP
rs1317519259 1053 dbSNP
rs969359833 1057 dbSNP
rs1230256219 1058 dbSNP
rs188613986 1063 dbSNP
rs571009120 1065 dbSNP
rs1000183954 1067 dbSNP
rs563782899 1073 dbSNP
rs978388930 1075 dbSNP
rs958798604 1084 dbSNP
rs1266050883 1085 dbSNP
rs1333102024 1087 dbSNP
rs925647163 1091 dbSNP
rs1434260495 1099 dbSNP
rs1201582683 1107 dbSNP
rs992831421 1112 dbSNP
rs746346387 1113 dbSNP
rs1425206364 1114 dbSNP
rs1413828350 1116 dbSNP
rs1410254415 1120 dbSNP
rs1472090723 1122 dbSNP
rs1240648600 1127 dbSNP
rs546447480 1134 dbSNP
rs1457554095 1138 dbSNP
rs1256586364 1147 dbSNP
rs937023799 1153 dbSNP
rs1312066095 1154 dbSNP
rs917076831 1154 dbSNP
rs1056090150 1156 dbSNP
rs1380482481 1158 dbSNP
rs1311280443 1159 dbSNP
rs570262671 1162 dbSNP
rs917194194 1176 dbSNP
rs1286359752 1181 dbSNP
rs561663844 1187 dbSNP
rs983019073 1188 dbSNP
rs1459105789 1190 dbSNP
rs1368318728 1192 dbSNP
rs1350172614 1195 dbSNP
rs909822684 1197 dbSNP
rs761432920 1199 dbSNP
rs1046961695 1202 dbSNP
rs886516508 1203 dbSNP
rs1179760528 1208 dbSNP
rs774852959 1214 dbSNP
rs1236698463 1215 dbSNP
rs1285075205 1218 dbSNP
rs181099925 1221 dbSNP
rs1265149065 1224 dbSNP
rs920892836 1226 dbSNP
rs1355869567 1227 dbSNP
rs933736378 1230 dbSNP
rs1227614066 1232 dbSNP
rs762595252 1237 dbSNP
rs1050900043 1240 dbSNP
rs1330857232 1242 dbSNP
rs763589878 1243 dbSNP
rs892208861 1243 dbSNP
rs532767144 1246 dbSNP
rs1037793509 1257 dbSNP
rs531860676 1264 dbSNP
rs1361853205 1271 dbSNP
rs1488498786 1272 dbSNP
rs535531794 1274 dbSNP
rs764671840 1275 dbSNP
rs1178681482 1276 dbSNP
rs1434057172 1277 dbSNP
rs1000378136 1279 dbSNP
rs1189639769 1280 dbSNP
rs1489409846 1281 dbSNP
rs543724711 1284 dbSNP
rs1216063230 1289 dbSNP
rs1352897979 1292 dbSNP
rs1474472498 1299 dbSNP
rs1472542557 1301 dbSNP
rs1258825767 1303 dbSNP
rs565849071 1304 dbSNP
rs1009006264 1305 dbSNP
rs1414559411 1308 dbSNP
rs1020441984 1316 dbSNP
rs967096863 1317 dbSNP
rs1164292215 1330 dbSNP
rs978439736 1335 dbSNP
rs1382142411 1337 dbSNP
rs534655204 1339 dbSNP
rs558180291 1343 dbSNP
rs1377382669 1350 dbSNP
rs185978634 1354 dbSNP
rs1478910303 1360 dbSNP
rs368092657 1367 dbSNP
rs958593558 1379 dbSNP
rs750899043 1389 dbSNP
rs917142477 1400 dbSNP
rs1024432149 1409 dbSNP
rs1258382189 1410 dbSNP
rs1202070634 1412 dbSNP
rs949984255 1421 dbSNP
rs1046929833 1422 dbSNP
rs112516393 1423 dbSNP
rs1201598759 1423 dbSNP
rs1288754815 1425 dbSNP
rs1278359239 1432 dbSNP
rs1217648708 1433 dbSNP
rs982665352 1435 dbSNP
rs1314285236 1443 dbSNP
rs1397087368 1451 dbSNP
rs1375182427 1452 dbSNP
rs191177266 1456 dbSNP
rs962622835 1465 dbSNP
rs1064448 1468 dbSNP
rs899264857 1473 dbSNP
rs996561874 1474 dbSNP
rs1170182909 1477 dbSNP
rs1050477321 1479 dbSNP
rs1321923367 1484 dbSNP
rs1474568358 1488 dbSNP
rs921175540 1491 dbSNP
rs890698797 1495 dbSNP
rs986855930 1510 dbSNP
rs1009141686 1516 dbSNP
rs1020494204 1519 dbSNP
rs1458877941 1519 dbSNP
rs112731098 1520 dbSNP
rs1337082742 1523 dbSNP
rs201536612 1527 dbSNP
rs376364346 1527 dbSNP
rs146451527 1536 dbSNP
rs755905777 1542 dbSNP
rs936262450 1546 dbSNP
rs1449683869 1548 dbSNP
rs1056005030 1549 dbSNP
rs1378063632 1549 dbSNP
rs1000340364 1550 dbSNP
rs542060712 1552 dbSNP
rs755399752 1558 dbSNP
rs77817811 1559 dbSNP
rs1181625284 1561 dbSNP
rs200948323 1564 dbSNP
rs750255719 1565 dbSNP
rs1238527036 1566 dbSNP
rs1180879235 1567 dbSNP
rs200280094 1568 dbSNP
rs527384520 1570 dbSNP
rs1004681418 1574 dbSNP
rs144247792 1577 dbSNP
rs146577429 1585 dbSNP
rs1289000114 1587 dbSNP
rs141333674 1592 dbSNP
rs1247628518 1601 dbSNP
rs1294781138 1602 dbSNP
rs550474875 1619 dbSNP
rs781324678 1620 dbSNP
rs748381243 1626 dbSNP
rs1229822992 1634 dbSNP
rs1160572588 1638 dbSNP
rs1275775834 1643 dbSNP
rs920661451 1650 dbSNP
rs955264061 1654 dbSNP
rs1157774978 1665 dbSNP
rs150249279 1675 dbSNP
rs1238408395 1681 dbSNP
rs1248269301 1682 dbSNP
rs1199084893 1687 dbSNP
rs529408774 1691 dbSNP
rs537196844 1692 dbSNP
rs752928261 1692 dbSNP
rs768654537 1696 dbSNP
rs1186849039 1708 dbSNP
rs180836351 1712 dbSNP
rs936210192 1716 dbSNP
rs1041920978 1721 dbSNP
rs1055869330 1733 dbSNP
rs1170540951 1736 dbSNP
rs903470589 1740 dbSNP
rs1300098135 1750 dbSNP
rs894758624 1752 dbSNP
rs950319312 1755 dbSNP
rs1359999299 1756 dbSNP
rs1421634570 1760 dbSNP
rs1398917936 1765 dbSNP
rs1000761210 1770 dbSNP
rs1426975754 1773 dbSNP
rs138909499 1774 dbSNP
rs1175093695 1775 dbSNP
rs1479898758 1775 dbSNP
rs1426852317 1788 dbSNP
rs1195404312 1793 dbSNP
rs1241038779 1803 dbSNP
rs1477828424 1803 dbSNP
rs566156219 1812 dbSNP
rs187580369 1813 dbSNP
rs1318071143 1831 dbSNP
rs887074208 1836 dbSNP
rs1363976361 1839 dbSNP
rs1203492162 1843 dbSNP
rs1321664373 1852 dbSNP
rs1435252409 1856 dbSNP
rs1219507310 1861 dbSNP
rs867965707 1868 dbSNP
rs894214927 1878 dbSNP
rs752714308 1884 dbSNP
rs1012630002 1885 dbSNP
rs1004209876 1886 dbSNP
rs1024070156 1887 dbSNP
rs537072790 1888 dbSNP
rs1334561560 1889 dbSNP
rs1469041497 1891 dbSNP
rs1403653958 1893 dbSNP
rs1172309422 1894 dbSNP
rs142343433 1901 dbSNP
rs56185828 1901 dbSNP
rs971023935 1904 dbSNP
rs982463767 1905 dbSNP
rs1028133132 1909 dbSNP
rs1279800725 1910 dbSNP
rs1326037363 1926 dbSNP
rs55881379 1927 dbSNP
rs117262234 1929 dbSNP
rs747048761 1930 dbSNP
rs1307187307 1935 dbSNP
rs974304364 1936 dbSNP
rs1270956742 1937 dbSNP
rs1230164065 1939 dbSNP
rs1379992166 1943 dbSNP
rs1315578696 1944 dbSNP
rs541999015 1947 dbSNP
rs1195500298 1954 dbSNP
rs1244986689 1955 dbSNP
rs1477006138 1958 dbSNP
rs932479014 1958 dbSNP
rs1020624668 1972 dbSNP
rs12444266 1980 dbSNP
rs1425641101 1980 dbSNP
rs1470854541 1990 dbSNP
rs555646856 1992 dbSNP
rs1167693647 1997 dbSNP
rs749436676 1997 dbSNP
rs1156662775 1998 dbSNP
rs1413901425 1999 dbSNP
rs1163465744 2000 dbSNP
rs1387531312 2000 dbSNP
rs1457440854 2017 dbSNP
rs1319724113 2020 dbSNP
rs966810869 2027 dbSNP
rs4785407 2029 dbSNP
rs925056204 2033 dbSNP
rs1224070195 2041 dbSNP
rs1231328543 2041 dbSNP
rs959101266 2041 dbSNP
rs1322354979 2046 dbSNP
rs1041731715 2053 dbSNP
rs541153870 2064 dbSNP
rs991629921 2082 dbSNP
rs190965570 2094 dbSNP
rs532911410 2101 dbSNP
rs1391819975 2109 dbSNP
rs1296029883 2110 dbSNP
rs1347914986 2110 dbSNP
rs1372347123 2110 dbSNP
rs1438213891 2114 dbSNP
rs1365628491 2115 dbSNP
rs1227005544 2117 dbSNP
rs1055119523 2119 dbSNP
rs575235975 2122 dbSNP
rs1418806420 2123 dbSNP
rs775568079 2124 dbSNP
rs1193094041 2128 dbSNP
rs916055100 2129 dbSNP
rs12918980 2131 dbSNP
rs148302203 2131 dbSNP
rs1489837124 2140 dbSNP
rs1207056876 2156 dbSNP
rs1024037652 2160 dbSNP
rs1304655845 2162 dbSNP
rs906974938 2164 dbSNP
rs1222353690 2165 dbSNP
rs1301988857 2166 dbSNP
rs940040972 2168 dbSNP
rs1269585990 2193 dbSNP
rs1481371986 2196 dbSNP
rs1343771143 2199 dbSNP
rs1178750816 2209 dbSNP
rs199909358 2211 dbSNP
rs374212153 2211 dbSNP
rs898596295 2214 dbSNP
rs1003867633 2225 dbSNP
rs1015303091 2227 dbSNP
rs1197537516 2230 dbSNP
rs962944078 2240 dbSNP
rs1264021892 2244 dbSNP
rs1205618798 2245 dbSNP
rs563595264 2247 dbSNP
rs1212061566 2248 dbSNP
rs1324004856 2255 dbSNP
rs1282181778 2256 dbSNP
rs1341794103 2257 dbSNP
rs529591878 2257 dbSNP
rs1295721287 2261 dbSNP
rs553376118 2261 dbSNP
rs1225006639 2267 dbSNP
rs771112633 2268 dbSNP
rs549158721 2272 dbSNP
rs373822923 2273 dbSNP
rs769180994 2273 dbSNP
rs890917143 2273 dbSNP
rs1470467097 2280 dbSNP
rs953873176 2280 dbSNP
rs1159891034 2281 dbSNP
rs1467407661 2288 dbSNP
rs1373697423 2291 dbSNP
rs1387988605 2292 dbSNP
rs1192642509 2297 dbSNP
rs1281744805 2303 dbSNP
rs1427848775 2310 dbSNP
rs987055183 2322 dbSNP
rs1404286118 2324 dbSNP
rs565969163 2324 dbSNP
rs1183541060 2326 dbSNP
rs1461565117 2333 dbSNP
rs1262312143 2336 dbSNP
rs79886276 2341 dbSNP
rs1368079895 2345 dbSNP
rs1408463089 2348 dbSNP
rs1288130503 2349 dbSNP
rs1226142939 2351 dbSNP
rs966135197 2354 dbSNP
rs1315368365 2355 dbSNP
rs1454003118 2356 dbSNP
rs1382440340 2360 dbSNP
rs977392013 2362 dbSNP
rs924577984 2368 dbSNP
rs1449267635 2372 dbSNP
rs1241483526 2386 dbSNP
rs370675918 2387 dbSNP
rs1031938615 2388 dbSNP
rs1167565251 2388 dbSNP
rs375461232 2388 dbSNP
rs1181586547 2390 dbSNP
rs368267322 2390 dbSNP
rs528376942 2390 dbSNP
rs530602866 2390 dbSNP
rs574113544 2390 dbSNP
rs745391456 2390 dbSNP
rs762385795 2390 dbSNP
rs77844678 2390 dbSNP
rs1282680033 2391 dbSNP
rs1355877276 2392 dbSNP
rs1229024830 2397 dbSNP
rs936008080 2397 dbSNP
rs35787328 2399 dbSNP
rs1294040847 2402 dbSNP
rs143823128 2402 dbSNP
rs1439189452 2404 dbSNP
rs1250709870 2407 dbSNP
rs1490822403 2407 dbSNP
rs959133905 2409 dbSNP
rs990490158 2409 dbSNP
rs763344636 2411 dbSNP
rs774304519 2411 dbSNP
rs917667876 2411 dbSNP
rs972012650 2413 dbSNP
rs398070800 2414 dbSNP
rs761222952 2414 dbSNP
rs1250833084 2415 dbSNP
rs551825615 2418 dbSNP
rs1183683744 2420 dbSNP
rs1366411695 2421 dbSNP
rs1472258426 2435 dbSNP
rs1328381121 2439 dbSNP
rs1163668552 2442 dbSNP
rs1389922152 2446 dbSNP
rs1386497934 2448 dbSNP
rs1392933543 2451 dbSNP
rs916168617 2452 dbSNP
rs940259383 2463 dbSNP
rs948897391 2464 dbSNP
rs1161598343 2471 dbSNP
rs1384603201 2471 dbSNP
rs1471006303 2487 dbSNP
rs1045959814 2488 dbSNP
rs574826750 2490 dbSNP
rs537411465 2494 dbSNP
rs919888779 2507 dbSNP
rs932733505 2509 dbSNP
rs1290152967 2511 dbSNP
rs1225999471 2518 dbSNP
rs879172242 2523 dbSNP
rs1351799756 2526 dbSNP
rs1004003579 2532 dbSNP
rs1237128034 2536 dbSNP
rs1428403693 2537 dbSNP
rs1283994925 2539 dbSNP
rs1307915524 2542 dbSNP
rs1363804350 2545 dbSNP
rs1036785083 2553 dbSNP
rs1371675321 2557 dbSNP
rs1393546031 2566 dbSNP
rs1049871066 2572 dbSNP
rs1385358676 2573 dbSNP
rs1157829788 2574 dbSNP
rs1468280847 2580 dbSNP
rs1430892965 2583 dbSNP
rs74402386 2588 dbSNP
rs935757103 2597 dbSNP
rs1266191356 2600 dbSNP
rs1218523346 2603 dbSNP
rs1448129206 2603 dbSNP
rs556518336 2604 dbSNP
rs1203823105 2607 dbSNP
rs1326107603 2609 dbSNP
rs995592724 2616 dbSNP
rs902440230 2618 dbSNP
rs1223152796 2623 dbSNP
rs1343674317 2625 dbSNP
rs1340079548 2628 dbSNP
rs1000713702 2631 dbSNP
rs1280219660 2631 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions hESCs (WA-09)
Disease 113.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in SRR359787. RNA binding protein: AGO2. Condition:4-thiouridine ...

- Lipchina I; Elkabetz Y; Hafner M; Sheridan et al., 2011, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' uuauuucagauacauACCGUu 5'
                         |||:| 
Target 5' -------aacaaugcUGGUAa 3'
 		1 - 14
Article - Lipchina I; Elkabetz Y; Hafner M; Sheridan et al.
- Genes & development, 2011
MicroRNAs are important regulators in many cellular processes, including stem cell self-renewal. Recent studies demonstrated their function as pluripotency factors with the capacity for somatic cell reprogramming. However, their role in human embryonic stem (ES) cells (hESCs) remains poorly understood, partially due to the lack of genome-wide strategies to identify their targets. Here, we performed comprehensive microRNA profiling in hESCs and in purified neural and mesenchymal derivatives. Using a combination of AGO cross-linking and microRNA perturbation experiments, together with computational prediction, we identified the targets of the miR-302/367 cluster, the most abundant microRNAs in hESCs. Functional studies identified novel roles of miR-302/367 in maintaining pluripotency and regulating hESC differentiation. We show that in addition to its role in TGF-beta signaling, miR-302/367 promotes bone morphogenetic protein (BMP) signaling by targeting BMP inhibitors TOB2, DAZAP2, and SLAIN1. This study broadens our understanding of microRNA function in hESCs and is a valuable resource for future studies in this area.
LinkOut: [PMID: 22012620]
CLIP-seq Support 1 for dataset SRR359787
Method / RBP PAR-CLIP / AGO2
Cell line / Condition hESCs (WA-09) / 4-thiouridine, RNase T1
Location of target site ENST00000394697.2 | 3UTR | AACAAUGCUGGUAAGGGC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22012620 / SRX103431
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
69 hsa-miR-5590-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT056313 WAC WW domain containing adaptor with coiled-coil 2 6
MIRT066181 PIP4K2C phosphatidylinositol-5-phosphate 4-kinase type 2 gamma 2 2
MIRT095612 NR3C1 nuclear receptor subfamily 3 group C member 1 2 2
MIRT099166 MYLIP myosin regulatory light chain interacting protein 2 2
MIRT107578 VLDLR very low density lipoprotein receptor 2 2
MIRT179602 CAPZA1 capping actin protein of muscle Z-line alpha subunit 1 2 8
MIRT241303 ZC3H12C zinc finger CCCH-type containing 12C 2 8
MIRT244620 MCM4 minichromosome maintenance complex component 4 2 2
MIRT270705 SBNO1 strawberry notch homolog 1 2 4
MIRT453616 SNRPE small nuclear ribonucleoprotein polypeptide E 2 4
MIRT453653 RAB6C RAB6C, member RAS oncogene family 2 2
MIRT464159 VMP1 vacuole membrane protein 1 2 15
MIRT477720 EEF1A1 eukaryotic translation elongation factor 1 alpha 1 2 2
MIRT484301 ENDOD1 endonuclease domain containing 1 2 4
MIRT496069 GLCCI1 glucocorticoid induced 1 2 2
MIRT496338 TMEM81 transmembrane protein 81 2 2
MIRT496653 PITPNM3 PITPNM family member 3 2 2
MIRT499098 DENND4C DENN domain containing 4C 2 8
MIRT499862 SVOP SV2 related protein 2 12
MIRT504913 CD38 CD38 molecule 2 4
MIRT515401 WDR72 WD repeat domain 72 2 4
MIRT518156 TMEM133 transmembrane protein 133 2 2
MIRT518558 GDPD1 glycerophosphodiester phosphodiesterase domain containing 1 2 2
MIRT518636 NOM1 nucleolar protein with MIF4G domain 1 2 2
MIRT518724 ABCG8 ATP binding cassette subfamily G member 8 2 2
MIRT524301 CTC1 CST telomere replication complex component 1 2 4
MIRT524472 CHRM3 cholinergic receptor muscarinic 3 2 4
MIRT527562 ADCY7 adenylate cyclase 7 2 2
MIRT532694 TCN2 transcobalamin 2 2 4
MIRT534640 RNF6 ring finger protein 6 2 2
MIRT537163 GGCX gamma-glutamyl carboxylase 2 2
MIRT539360 AFF4 AF4/FMR2 family member 4 2 2
MIRT547023 PPP1CB protein phosphatase 1 catalytic subunit beta 2 2
MIRT548155 FRAT2 FRAT2, WNT signaling pathway regulator 2 2
MIRT550127 ZNF138 zinc finger protein 138 2 2
MIRT558473 DBN1 drebrin 1 2 2
MIRT566862 LRRC58 leucine rich repeat containing 58 2 2
MIRT567246 HSP90AA1 heat shock protein 90 alpha family class A member 1 2 2
MIRT572848 BRPF3 bromodomain and PHD finger containing 3 2 2
MIRT574914 Vmp1 vacuole membrane protein 1 2 9
MIRT606849 RAB7A RAB7A, member RAS oncogene family 2 2
MIRT611274 RBMXL1 RNA binding motif protein, X-linked like 1 2 2
MIRT612328 TRPS1 transcriptional repressor GATA binding 1 2 2
MIRT612415 SP1 Sp1 transcription factor 2 2
MIRT614791 RRAGC Ras related GTP binding C 2 2
MIRT618449 SERPINA3 serpin family A member 3 2 2
MIRT621154 MICALCL MICAL C-terminal like 2 2
MIRT622141 SOX4 SRY-box 4 2 2
MIRT623504 KCNK5 potassium two pore domain channel subfamily K member 5 2 2
MIRT623598 IPO9 importin 9 2 2
MIRT624075 EBF1 early B-cell factor 1 2 2
MIRT639792 MVK mevalonate kinase 2 2
MIRT641109 ZNF274 zinc finger protein 274 2 2
MIRT641579 RFX1 regulatory factor X1 2 2
MIRT643095 NDUFB5 NADH:ubiquinone oxidoreductase subunit B5 2 2
MIRT645141 CUBN cubilin 2 2
MIRT646461 PRDM10 PR/SET domain 10 2 2
MIRT650815 HMOX1 heme oxygenase 1 2 2
MIRT653073 ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 2 2
MIRT657675 GPR26 G protein-coupled receptor 26 2 2
MIRT665824 TIMM8B translocase of inner mitochondrial membrane 8 homolog B 2 2
MIRT695592 TMEM199 transmembrane protein 199 2 2
MIRT698039 TRPM7 transient receptor potential cation channel subfamily M member 7 2 2
MIRT701015 PCGF5 polycomb group ring finger 5 2 2
MIRT701357 NR4A3 nuclear receptor subfamily 4 group A member 3 2 2
MIRT707114 NWD1 NACHT and WD repeat domain containing 1 2 2
MIRT718661 HNF4A hepatocyte nuclear factor 4 alpha 2 2
MIRT719901 SERP1 stress associated endoplasmic reticulum protein 1 2 2
MIRT720564 C1RL complement C1r subcomponent like 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-5590-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)

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