>BRD7|NM_001173984|3'UTR
   1 GGCTGCCTGGTATTTGATTATATATTATGTACATACTTTTTCATTCTTAACTTAGAAATGCTTTTCAGAAGATATTAAAT
  81 ATTTGTAAATTGTGTTTTTAATTAAACTTTGGAACAGCGAATTTGGATGTTCCAGAGGTTGGACTTGTATTAGGTAATAA
 161 AGCTGGACCTGGGACTCGTGAGGAAGGAATGTGAAAAAAAAAAAAAAAAAA

ID	Duplex structure	Position	Score	MFE
1	miRNA 3' agUGUUC-ACUU---CAUCACCCu 5' | |:| ||:| ||| | || Target 5' ccAGAGGTTGGACTTGTATTAGGt 3'	132 - 155	90.00	-5.30
2	miRNA 3' agUGUUCACUUCAUCACCCu 5' || | |:| | ||| | Target 5' ggACCTG-GGACTCGTGAGg 3'	165 - 183	85.00	-6.10

Mutant ID	Mutant Position	Mutant Source
COSN30154813	12	COSMIC
COSN30529673	33	COSMIC
COSN31481923	55	COSMIC
COSN22194232	66	COSMIC
COSN31573978	83	COSMIC
COSN30113111	118	COSMIC
COSN31602000	119	COSMIC
COSN31548918	137	COSMIC
COSN26586115	218	COSMIC
COSN20112864	1292	COSMIC
COSN20112866	1293	COSMIC
COSN5407421	1389	COSMIC
COSN22353493	1413	COSMIC
COSN27773734	1511	COSMIC
COSN31538573	2035	COSMIC
COSN26576527	2061	COSMIC
COSN31485549	2100	COSMIC
COSN31593734	2103	COSMIC
COSN31585580	2136	COSMIC
COSN32062287	2422	COSMIC
COSN31961202	2622	COSMIC
COSN9647458	2889	COSMIC
COSN7259101	2920	COSMIC
rs1872691	2912	GWAS

Mutant ID	Mutant Position	Mutant Source
rs751528435	1	dbSNP
rs192811063	7	dbSNP
rs758180358	19	dbSNP
rs570981850	20	dbSNP
rs752321817	26	dbSNP
rs1482778827	28	dbSNP
rs1205224875	29	dbSNP
rs764892828	32	dbSNP
rs1264859942	34	dbSNP
rs935287920	36	dbSNP
rs1226479250	37	dbSNP
rs902431314	37	dbSNP
rs1335016640	39	dbSNP
rs758978675	40	dbSNP
rs1392797142	45	dbSNP
rs1376470730	49	dbSNP
rs1181465424	51	dbSNP
rs534770850	61	dbSNP
rs1454167761	67	dbSNP
rs966001016	75	dbSNP
rs1019904848	92	dbSNP
rs1383041945	106	dbSNP
rs943688391	115	dbSNP
rs910990156	118	dbSNP
rs985587359	119	dbSNP
rs931510036	120	dbSNP
rs1446892910	142	dbSNP
rs1464256596	158	dbSNP
rs1007462680	177	dbSNP
rs138739351	178	dbSNP
rs1170885585	187	dbSNP
rs780379768	190	dbSNP
rs1342866363	193	dbSNP
rs372824514	203	dbSNP
rs1388311193	204	dbSNP
rs552670622	206	dbSNP
rs549268552	209	dbSNP
rs961649929	217	dbSNP
rs1209708844	230	dbSNP
rs756269860	230	dbSNP
rs1462936782	233	dbSNP
rs1187137889	234	dbSNP
rs1389925197	237	dbSNP
rs1476053377	238	dbSNP
rs530945516	246	dbSNP
rs1036014689	248	dbSNP
rs1243861644	253	dbSNP
rs1413361693	257	dbSNP
rs563489348	259	dbSNP
rs1482408422	260	dbSNP
rs1234889129	261	dbSNP
rs1205741860	262	dbSNP
rs1407760197	264	dbSNP
rs981456511	267	dbSNP
rs1319710270	271	dbSNP
rs1326772940	273	dbSNP
rs1432843639	274	dbSNP
rs1342052688	278	dbSNP
rs1272949998	280	dbSNP
rs770259248	282	dbSNP
rs1342978209	287	dbSNP
rs970016211	288	dbSNP
rs866563440	291	dbSNP
rs1247493379	292	dbSNP
rs1359485649	301	dbSNP
rs542341310	302	dbSNP
rs368933364	305	dbSNP
rs1447903189	308	dbSNP
rs1195986649	319	dbSNP
rs567695810	324	dbSNP
rs550984455	325	dbSNP
rs530953052	328	dbSNP
rs1430772465	329	dbSNP
rs565333907	331	dbSNP
rs551691060	332	dbSNP
rs1385429195	338	dbSNP
rs548561513	340	dbSNP
rs1383645642	346	dbSNP
rs187945831	348	dbSNP
rs147159153	351	dbSNP
rs924056761	366	dbSNP
rs182530342	367	dbSNP
rs1226832693	388	dbSNP
rs889418371	401	dbSNP
rs781568115	417	dbSNP
rs1351869663	419	dbSNP
rs1385883001	430	dbSNP
rs375776351	431	dbSNP
rs1164175046	432	dbSNP
rs1049498514	435	dbSNP
rs755276924	438	dbSNP
rs1007102436	439	dbSNP
rs867334687	443	dbSNP
rs1482956215	447	dbSNP
rs1250105727	448	dbSNP
rs1225303431	454	dbSNP
rs1471295169	455	dbSNP
rs1181026240	474	dbSNP
rs1363951969	474	dbSNP
rs1490659815	475	dbSNP
rs1264347456	477	dbSNP
rs973332283	478	dbSNP
rs143422120	495	dbSNP
rs928883452	499	dbSNP
rs1389717813	501	dbSNP
rs568214404	503	dbSNP
rs970049026	504	dbSNP
rs1222885895	506	dbSNP
rs1306569677	508	dbSNP
rs1348346186	510	dbSNP
rs1023425346	511	dbSNP
rs1304746823	511	dbSNP
rs1405414147	514	dbSNP
rs1241437477	517	dbSNP
rs1282845427	520	dbSNP
rs1364953640	520	dbSNP
rs990158046	524	dbSNP
rs1223909538	527	dbSNP
rs1294511453	527	dbSNP
rs1456495566	531	dbSNP
rs937740913	534	dbSNP
rs1481789213	547	dbSNP
rs1160051119	548	dbSNP
rs1472399674	549	dbSNP
rs1250595771	552	dbSNP
rs1420550473	554	dbSNP
rs1036155803	560	dbSNP
rs1367707577	564	dbSNP
rs1165412497	565	dbSNP
rs1410140501	565	dbSNP
rs1444969042	565	dbSNP
rs1429023515	570	dbSNP
rs1297740074	572	dbSNP
rs562986603	581	dbSNP
rs1202045831	597	dbSNP
rs1481043411	601	dbSNP
rs1004949564	608	dbSNP
rs766789758	615	dbSNP
rs1332377972	616	dbSNP
rs762579157	616	dbSNP
rs999333497	617	dbSNP
rs1317605711	622	dbSNP
rs1340733070	626	dbSNP
rs1260829803	631	dbSNP
rs1227307600	632	dbSNP
rs916511128	633	dbSNP
rs1207652381	635	dbSNP
rs1326650390	636	dbSNP
rs1242083529	639	dbSNP
rs1284950718	653	dbSNP
rs1461610198	654	dbSNP
rs1223948527	659	dbSNP
rs1388077702	659	dbSNP
rs1448841588	662	dbSNP
rs545009330	675	dbSNP
rs1373751121	678	dbSNP
rs1299152377	679	dbSNP
rs1463537849	680	dbSNP
rs1383882641	685	dbSNP
rs936532416	688	dbSNP
rs966488727	693	dbSNP
rs1453637962	694	dbSNP
rs924020508	705	dbSNP
rs978166644	721	dbSNP
rs1382184814	723	dbSNP
rs561633893	730	dbSNP
rs548078724	731	dbSNP
rs912539677	738	dbSNP
rs1323889515	741	dbSNP
rs1179006567	744	dbSNP
rs985876915	746	dbSNP
rs1246009227	748	dbSNP
rs1019500360	749	dbSNP
rs190257513	750	dbSNP
rs572667020	751	dbSNP
rs749875872	752	dbSNP
rs543404612	761	dbSNP
rs1470530231	766	dbSNP
rs954263181	771	dbSNP
rs1377455649	787	dbSNP
rs1174118904	796	dbSNP
rs757541471	796	dbSNP
rs777851021	797	dbSNP
rs577670921	800	dbSNP
rs906295175	801	dbSNP
rs146352835	803	dbSNP
rs1282143974	805	dbSNP
rs1011897572	809	dbSNP
rs1316122535	811	dbSNP
rs535031572	811	dbSNP
rs546289021	811	dbSNP
rs59889907	811	dbSNP
rs71382315	811	dbSNP
rs1268304686	812	dbSNP
rs1480775114	816	dbSNP
rs1049896627	821	dbSNP
rs1053669575	824	dbSNP
rs936599522	828	dbSNP
rs1160368452	831	dbSNP
rs1264669411	833	dbSNP
rs1456876487	834	dbSNP
rs1303034975	835	dbSNP
rs995163217	842	dbSNP
rs1489577175	847	dbSNP
rs898256320	848	dbSNP
rs80244110	852	dbSNP
rs902303997	857	dbSNP
rs143843027	859	dbSNP
rs1319655623	860	dbSNP
rs1254051093	868	dbSNP
rs185982116	877	dbSNP
rs1247408879	881	dbSNP
rs1221682454	883	dbSNP
rs928749354	887	dbSNP
rs1229445559	888	dbSNP
rs1045929626	891	dbSNP
rs949020970	894	dbSNP
rs1326956002	898	dbSNP
rs766460572	900	dbSNP
rs1434531623	901	dbSNP
rs1469866765	902	dbSNP
rs1363253994	905	dbSNP
rs1410661553	911	dbSNP
rs944106307	911	dbSNP
rs1453684213	914	dbSNP
rs572295114	916	dbSNP
rs760584659	917	dbSNP
rs1353382347	920	dbSNP
rs1427093443	920	dbSNP
rs1171192767	922	dbSNP
rs760124451	923	dbSNP
rs199684168	925	dbSNP
rs869035766	925	dbSNP
rs990580786	925	dbSNP
rs200867614	926	dbSNP
rs1244884963	928	dbSNP
rs1315468722	930	dbSNP
rs1361579613	930	dbSNP
rs1167387509	937	dbSNP
rs1226057696	939	dbSNP
rs149001146	940	dbSNP
rs1437274222	955	dbSNP
rs1205520698	961	dbSNP
rs1234763373	962	dbSNP
rs764977194	962	dbSNP
rs974290293	964	dbSNP
rs961627103	970	dbSNP
rs1015740816	973	dbSNP
rs1166620718	977	dbSNP
rs761585312	979	dbSNP
rs1409980249	980	dbSNP
rs1244474785	981	dbSNP
rs1183768872	984	dbSNP
rs767202141	985	dbSNP
rs1253733852	986	dbSNP
rs1384690928	986	dbSNP
rs1432851224	987	dbSNP
rs982031488	990	dbSNP
rs1338841409	993	dbSNP
rs1215170410	995	dbSNP
rs1275187014	999	dbSNP
rs761421608	1002	dbSNP
rs966521082	1005	dbSNP
rs970490457	1015	dbSNP
rs1011864991	1016	dbSNP
rs575292483	1016	dbSNP
rs535786256	1019	dbSNP
rs1241972954	1021	dbSNP
rs1019448116	1025	dbSNP
rs1187825064	1037	dbSNP
rs1008009850	1038	dbSNP
rs1469008969	1039	dbSNP
rs1176662511	1050	dbSNP
rs776378096	1053	dbSNP
rs1273880677	1054	dbSNP
rs1226130997	1055	dbSNP
rs569961998	1058	dbSNP
rs1028215976	1075	dbSNP
rs1000713702	1076	dbSNP
rs1280219660	1076	dbSNP
rs1340079548	1079	dbSNP
rs1343674317	1082	dbSNP
rs1223152796	1084	dbSNP
rs902440230	1089	dbSNP
rs995592724	1091	dbSNP
rs1326107603	1098	dbSNP
rs1203823105	1100	dbSNP
rs556518336	1103	dbSNP
rs1218523346	1104	dbSNP
rs1448129206	1104	dbSNP
rs1266191356	1107	dbSNP
rs935757103	1110	dbSNP
rs74402386	1119	dbSNP
rs1430892965	1124	dbSNP
rs1468280847	1127	dbSNP
rs1157829788	1133	dbSNP
rs1385358676	1134	dbSNP
rs1049871066	1135	dbSNP
rs1393546031	1141	dbSNP
rs1371675321	1150	dbSNP
rs1036785083	1154	dbSNP
rs1363804350	1162	dbSNP
rs1307915524	1165	dbSNP
rs1283994925	1168	dbSNP
rs1428403693	1170	dbSNP
rs1237128034	1171	dbSNP
rs1004003579	1175	dbSNP
rs1351799756	1181	dbSNP
rs879172242	1184	dbSNP
rs1225999471	1189	dbSNP
rs1290152967	1196	dbSNP
rs932733505	1198	dbSNP
rs919888779	1200	dbSNP
rs537411465	1213	dbSNP
rs574826750	1217	dbSNP
rs1045959814	1219	dbSNP
rs1471006303	1220	dbSNP
rs1161598343	1236	dbSNP
rs1384603201	1236	dbSNP
rs948897391	1243	dbSNP
rs940259383	1244	dbSNP
rs916168617	1255	dbSNP
rs1392933543	1256	dbSNP
rs1386497934	1259	dbSNP
rs1389922152	1261	dbSNP
rs1163668552	1265	dbSNP
rs1328381121	1268	dbSNP
rs1472258426	1272	dbSNP
rs1366411695	1286	dbSNP
rs1183683744	1287	dbSNP
rs551825615	1289	dbSNP
rs1250833084	1292	dbSNP
rs398070800	1293	dbSNP
rs761222952	1293	dbSNP
rs972012650	1294	dbSNP
rs763344636	1296	dbSNP
rs774304519	1296	dbSNP
rs917667876	1296	dbSNP
rs959133905	1298	dbSNP
rs990490158	1298	dbSNP
rs1250709870	1300	dbSNP
rs1490822403	1300	dbSNP
rs1439189452	1303	dbSNP
rs1294040847	1305	dbSNP
rs143823128	1305	dbSNP
rs35787328	1308	dbSNP
rs1229024830	1310	dbSNP
rs936008080	1310	dbSNP
rs1355877276	1315	dbSNP
rs1282680033	1316	dbSNP
rs1181586547	1317	dbSNP
rs368267322	1317	dbSNP
rs528376942	1317	dbSNP
rs530602866	1317	dbSNP
rs574113544	1317	dbSNP
rs745391456	1317	dbSNP
rs762385795	1317	dbSNP
rs77844678	1317	dbSNP
rs1031938615	1319	dbSNP
rs1167565251	1319	dbSNP
rs375461232	1319	dbSNP
rs370675918	1320	dbSNP
rs1241483526	1321	dbSNP
rs1449267635	1335	dbSNP
rs924577984	1339	dbSNP
rs977392013	1345	dbSNP
rs1382440340	1347	dbSNP
rs1454003118	1351	dbSNP
rs1315368365	1352	dbSNP
rs966135197	1353	dbSNP
rs1226142939	1356	dbSNP
rs1288130503	1358	dbSNP
rs1408463089	1359	dbSNP
rs1368079895	1362	dbSNP
rs79886276	1366	dbSNP
rs1262312143	1371	dbSNP
rs1461565117	1374	dbSNP
rs1183541060	1381	dbSNP
rs1404286118	1383	dbSNP
rs565969163	1383	dbSNP
rs987055183	1385	dbSNP
rs1427848775	1397	dbSNP
rs1281744805	1404	dbSNP
rs1192642509	1410	dbSNP
rs1387988605	1415	dbSNP
rs1373697423	1416	dbSNP
rs1467407661	1419	dbSNP
rs1159891034	1426	dbSNP
rs1470467097	1427	dbSNP
rs953873176	1427	dbSNP
rs373822923	1434	dbSNP
rs769180994	1434	dbSNP
rs890917143	1434	dbSNP
rs549158721	1435	dbSNP
rs771112633	1439	dbSNP
rs1225006639	1440	dbSNP
rs1295721287	1446	dbSNP
rs553376118	1446	dbSNP
rs1341794103	1450	dbSNP
rs529591878	1450	dbSNP
rs1282181778	1451	dbSNP
rs1324004856	1452	dbSNP
rs1212061566	1459	dbSNP
rs563595264	1460	dbSNP
rs1205618798	1462	dbSNP
rs1264021892	1463	dbSNP
rs962944078	1467	dbSNP
rs1197537516	1477	dbSNP
rs1015303091	1480	dbSNP
rs1003867633	1482	dbSNP
rs898596295	1493	dbSNP
rs199909358	1496	dbSNP
rs374212153	1496	dbSNP
rs1178750816	1498	dbSNP
rs1343771143	1508	dbSNP
rs1481371986	1511	dbSNP
rs1269585990	1514	dbSNP
rs940040972	1539	dbSNP
rs1301988857	1541	dbSNP
rs1222353690	1542	dbSNP
rs906974938	1543	dbSNP
rs1304655845	1545	dbSNP
rs1024037652	1547	dbSNP
rs1207056876	1551	dbSNP
rs1489837124	1567	dbSNP
rs12918980	1576	dbSNP
rs148302203	1576	dbSNP
rs916055100	1578	dbSNP
rs1193094041	1579	dbSNP
rs775568079	1583	dbSNP
rs1418806420	1584	dbSNP
rs575235975	1585	dbSNP
rs1055119523	1588	dbSNP
rs1227005544	1590	dbSNP
rs1365628491	1592	dbSNP
rs1438213891	1593	dbSNP
rs1296029883	1597	dbSNP
rs1347914986	1597	dbSNP
rs1372347123	1597	dbSNP
rs1391819975	1598	dbSNP
rs532911410	1606	dbSNP
rs190965570	1613	dbSNP
rs991629921	1625	dbSNP
rs541153870	1643	dbSNP
rs1041731715	1654	dbSNP
rs1322354979	1661	dbSNP
rs1224070195	1666	dbSNP
rs1231328543	1666	dbSNP
rs959101266	1666	dbSNP
rs925056204	1674	dbSNP
rs4785407	1678	dbSNP
rs966810869	1680	dbSNP
rs1319724113	1687	dbSNP
rs1457440854	1690	dbSNP
rs1163465744	1707	dbSNP
rs1387531312	1707	dbSNP
rs1413901425	1708	dbSNP
rs1156662775	1709	dbSNP
rs1167693647	1710	dbSNP
rs749436676	1710	dbSNP
rs555646856	1715	dbSNP
rs1470854541	1717	dbSNP
rs12444266	1727	dbSNP
rs1425641101	1727	dbSNP
rs1020624668	1735	dbSNP
rs1477006138	1749	dbSNP
rs932479014	1749	dbSNP
rs1244986689	1752	dbSNP
rs1195500298	1753	dbSNP
rs541999015	1760	dbSNP
rs1315578696	1763	dbSNP
rs1379992166	1764	dbSNP
rs1230164065	1768	dbSNP
rs1270956742	1770	dbSNP
rs974304364	1771	dbSNP
rs1307187307	1772	dbSNP
rs747048761	1777	dbSNP
rs117262234	1778	dbSNP
rs55881379	1780	dbSNP
rs1326037363	1781	dbSNP
rs1279800725	1797	dbSNP
rs1028133132	1798	dbSNP
rs982463767	1802	dbSNP
rs971023935	1803	dbSNP
rs142343433	1806	dbSNP
rs56185828	1806	dbSNP
rs1172309422	1813	dbSNP
rs1403653958	1814	dbSNP
rs1469041497	1816	dbSNP
rs1334561560	1818	dbSNP
rs537072790	1819	dbSNP
rs1024070156	1820	dbSNP
rs1004209876	1821	dbSNP
rs1012630002	1822	dbSNP
rs752714308	1823	dbSNP
rs894214927	1829	dbSNP
rs867965707	1839	dbSNP
rs1219507310	1846	dbSNP
rs1435252409	1851	dbSNP
rs1321664373	1855	dbSNP
rs1203492162	1864	dbSNP
rs1363976361	1868	dbSNP
rs887074208	1871	dbSNP
rs1318071143	1876	dbSNP
rs187580369	1894	dbSNP
rs566156219	1895	dbSNP
rs1241038779	1904	dbSNP
rs1477828424	1904	dbSNP
rs1195404312	1914	dbSNP
rs1426852317	1919	dbSNP
rs1175093695	1932	dbSNP
rs1479898758	1932	dbSNP
rs138909499	1933	dbSNP
rs1426975754	1934	dbSNP
rs1000761210	1937	dbSNP
rs1398917936	1942	dbSNP
rs1421634570	1947	dbSNP
rs1359999299	1951	dbSNP
rs950319312	1952	dbSNP
rs894758624	1955	dbSNP
rs1300098135	1957	dbSNP
rs903470589	1967	dbSNP
rs1170540951	1971	dbSNP
rs1055869330	1974	dbSNP
rs1041920978	1986	dbSNP
rs936210192	1991	dbSNP
rs180836351	1995	dbSNP
rs1186849039	1999	dbSNP
rs768654537	2011	dbSNP
rs537196844	2015	dbSNP
rs752928261	2015	dbSNP
rs529408774	2016	dbSNP
rs1199084893	2020	dbSNP
rs1248269301	2025	dbSNP
rs1238408395	2026	dbSNP
rs150249279	2032	dbSNP
rs1157774978	2042	dbSNP
rs955264061	2053	dbSNP
rs920661451	2057	dbSNP
rs1275775834	2064	dbSNP
rs1160572588	2069	dbSNP
rs1229822992	2073	dbSNP
rs748381243	2081	dbSNP
rs781324678	2087	dbSNP
rs550474875	2088	dbSNP
rs1294781138	2105	dbSNP
rs1247628518	2106	dbSNP
rs141333674	2115	dbSNP
rs1289000114	2120	dbSNP
rs146577429	2122	dbSNP
rs144247792	2130	dbSNP
rs1004681418	2133	dbSNP
rs527384520	2137	dbSNP
rs200280094	2139	dbSNP
rs1180879235	2140	dbSNP
rs1238527036	2141	dbSNP
rs750255719	2142	dbSNP
rs200948323	2143	dbSNP
rs1181625284	2146	dbSNP
rs77817811	2148	dbSNP
rs755399752	2149	dbSNP
rs542060712	2155	dbSNP
rs1000340364	2157	dbSNP
rs1056005030	2158	dbSNP
rs1378063632	2158	dbSNP
rs1449683869	2159	dbSNP
rs936262450	2161	dbSNP
rs755905777	2165	dbSNP
rs146451527	2171	dbSNP
rs201536612	2180	dbSNP
rs376364346	2180	dbSNP
rs1337082742	2184	dbSNP
rs112731098	2187	dbSNP
rs1020494204	2188	dbSNP
rs1458877941	2188	dbSNP
rs1009141686	2191	dbSNP
rs986855930	2197	dbSNP
rs890698797	2212	dbSNP
rs921175540	2216	dbSNP
rs1474568358	2219	dbSNP
rs1321923367	2223	dbSNP
rs1050477321	2228	dbSNP
rs1170182909	2230	dbSNP
rs996561874	2233	dbSNP
rs899264857	2234	dbSNP
rs1064448	2239	dbSNP
rs962622835	2242	dbSNP
rs191177266	2251	dbSNP
rs1375182427	2255	dbSNP
rs1397087368	2256	dbSNP
rs1314285236	2264	dbSNP
rs982665352	2272	dbSNP
rs1217648708	2274	dbSNP
rs1278359239	2275	dbSNP
rs1288754815	2282	dbSNP
rs112516393	2284	dbSNP
rs1201598759	2284	dbSNP
rs1046929833	2285	dbSNP
rs949984255	2286	dbSNP
rs1202070634	2295	dbSNP
rs1258382189	2297	dbSNP
rs1024432149	2298	dbSNP
rs917142477	2307	dbSNP
rs750899043	2318	dbSNP
rs958593558	2328	dbSNP
rs368092657	2340	dbSNP
rs1478910303	2347	dbSNP
rs185978634	2353	dbSNP
rs1377382669	2357	dbSNP
rs558180291	2364	dbSNP
rs534655204	2368	dbSNP
rs1382142411	2370	dbSNP
rs978439736	2372	dbSNP
rs1164292215	2377	dbSNP
rs967096863	2390	dbSNP
rs1020441984	2391	dbSNP
rs1414559411	2399	dbSNP
rs1009006264	2402	dbSNP
rs565849071	2403	dbSNP
rs1258825767	2404	dbSNP
rs1472542557	2406	dbSNP
rs1474472498	2408	dbSNP
rs1352897979	2415	dbSNP
rs1216063230	2418	dbSNP
rs543724711	2423	dbSNP
rs1489409846	2426	dbSNP
rs1189639769	2427	dbSNP
rs1000378136	2428	dbSNP
rs1434057172	2430	dbSNP
rs1178681482	2431	dbSNP
rs764671840	2432	dbSNP
rs535531794	2433	dbSNP
rs1488498786	2435	dbSNP
rs1361853205	2436	dbSNP
rs531860676	2443	dbSNP
rs1037793509	2450	dbSNP
rs532767144	2461	dbSNP
rs763589878	2464	dbSNP
rs892208861	2464	dbSNP
rs1330857232	2465	dbSNP
rs1050900043	2467	dbSNP
rs762595252	2470	dbSNP
rs1227614066	2475	dbSNP
rs933736378	2477	dbSNP
rs1355869567	2480	dbSNP
rs920892836	2481	dbSNP
rs1265149065	2483	dbSNP
rs181099925	2486	dbSNP
rs1285075205	2489	dbSNP
rs1236698463	2492	dbSNP
rs774852959	2493	dbSNP
rs1179760528	2499	dbSNP
rs886516508	2504	dbSNP
rs1046961695	2505	dbSNP
rs761432920	2508	dbSNP
rs909822684	2510	dbSNP
rs1350172614	2512	dbSNP
rs1368318728	2515	dbSNP
rs1459105789	2517	dbSNP
rs983019073	2519	dbSNP
rs561663844	2520	dbSNP
rs1286359752	2526	dbSNP
rs917194194	2531	dbSNP
rs570262671	2545	dbSNP
rs1311280443	2548	dbSNP
rs1380482481	2549	dbSNP
rs1056090150	2551	dbSNP
rs1312066095	2553	dbSNP
rs917076831	2553	dbSNP
rs937023799	2554	dbSNP
rs1256586364	2560	dbSNP
rs1457554095	2569	dbSNP
rs546447480	2573	dbSNP
rs1240648600	2580	dbSNP
rs1472090723	2585	dbSNP
rs1410254415	2587	dbSNP
rs1413828350	2591	dbSNP
rs1425206364	2593	dbSNP
rs746346387	2594	dbSNP
rs992831421	2595	dbSNP
rs1201582683	2600	dbSNP
rs1434260495	2608	dbSNP
rs925647163	2616	dbSNP
rs1333102024	2620	dbSNP
rs1266050883	2622	dbSNP
rs958798604	2623	dbSNP
rs978388930	2632	dbSNP
rs563782899	2634	dbSNP
rs1000183954	2640	dbSNP
rs571009120	2642	dbSNP
rs188613986	2644	dbSNP
rs1230256219	2649	dbSNP
rs969359833	2650	dbSNP
rs1317519259	2654	dbSNP
rs912963899	2663	dbSNP
rs1020575816	2665	dbSNP
rs987617004	2672	dbSNP
rs1207753860	2673	dbSNP
rs1326760658	2675	dbSNP
rs1237560212	2686	dbSNP
rs1483906776	2690	dbSNP
rs1190868903	2695	dbSNP
rs1422547547	2697	dbSNP
rs1257560092	2705	dbSNP
rs1233795257	2707	dbSNP
rs1172605424	2714	dbSNP
rs1422752841	2716	dbSNP
rs1334672148	2718	dbSNP
rs763837174	2719	dbSNP
rs1359820774	2722	dbSNP
rs890595925	2723	dbSNP
rs1296409451	2728	dbSNP
rs955013581	2735	dbSNP
rs1400807228	2736	dbSNP
rs1052366165	2737	dbSNP
rs1029254796	2750	dbSNP
rs777238833	2752	dbSNP
rs899611694	2760	dbSNP
rs1280029255	2761	dbSNP
rs1314442591	2761	dbSNP
rs1438863083	2764	dbSNP
rs1461235971	2765	dbSNP
rs975360135	2770	dbSNP
rs1488430623	2773	dbSNP
rs541438484	2776	dbSNP
rs760607802	2778	dbSNP
rs1434674919	2779	dbSNP
rs1477536955	2781	dbSNP
rs1016308179	2784	dbSNP
rs1386824621	2789	dbSNP
rs56018511	2791	dbSNP
rs1046939538	2792	dbSNP
rs1156977833	2796	dbSNP
rs1466994542	2797	dbSNP
rs1420547360	2798	dbSNP
rs1320473339	2800	dbSNP
rs1329552310	2805	dbSNP
rs929884346	2808	dbSNP
rs1275781679	2811	dbSNP
rs1373893019	2814	dbSNP
rs747308946	2817	dbSNP
rs561788535	2830	dbSNP
rs577269390	2831	dbSNP
rs1025042433	2836	dbSNP
rs1218355001	2843	dbSNP
rs1287367831	2851	dbSNP
rs1014104358	2853	dbSNP
rs895596917	2855	dbSNP
rs563983986	2863	dbSNP
rs1463269145	2865	dbSNP
rs1177862737	2874	dbSNP
rs1379783647	2877	dbSNP
rs1258002536	2883	dbSNP
rs1160371991	2886	dbSNP
rs1388898293	2894	dbSNP
rs1404966349	2901	dbSNP
rs1324643446	2907	dbSNP
rs1872691	2912	dbSNP
rs370643134	2913	dbSNP
rs1020712885	2921	dbSNP
rs1378277534	2922	dbSNP
rs989038174	2924	dbSNP
rs1281890622	2925	dbSNP
rs1042727362	2930	dbSNP
rs1210008713	2933	dbSNP
rs1291797133	2934	dbSNP
rs1456238220	2938	dbSNP
rs1197768909	2939	dbSNP
rs1230558931	2943	dbSNP
rs769867359	2945	dbSNP
rs1184139534	2948	dbSNP
rs1366744758	2951	dbSNP
rs1472610351	2960	dbSNP
rs996369804	2962	dbSNP
rs899580287	2967	dbSNP
rs1344345768	2968	dbSNP
rs945690394	2970	dbSNP
rs1420489273	2974	dbSNP
rs1464444680	2980	dbSNP
rs1331090042	2985	dbSNP
rs1401710796	2992	dbSNP
rs1298440075	2996	dbSNP
rs562745185	2997	dbSNP
rs1331647565	2999	dbSNP
rs987146653	3001	dbSNP
rs1294811858	3002	dbSNP
rs1315681413	3003	dbSNP
rs1217830261	3006	dbSNP
rs1227938878	3010	dbSNP
rs1258444593	3022	dbSNP
rs796159926	3024	dbSNP
rs1198621806	3027	dbSNP
rs1254175278	3032	dbSNP
rs1441854685	3039	dbSNP
rs1188316655	3041	dbSNP
rs575276298	3046	dbSNP
rs1047186489	3047	dbSNP
rs1424722116	3049	dbSNP
rs558099056	3066	dbSNP
rs1171265128	3070	dbSNP
rs1402107779	3072	dbSNP
rs929879852	3073	dbSNP
rs922134518	3074	dbSNP
rs748308848	3077	dbSNP
rs1398956418	3079	dbSNP
rs1401985983	3090	dbSNP
rs762611555	3090	dbSNP
rs75831772	3094	dbSNP
rs1308969284	3101	dbSNP
rs927376264	3117	dbSNP
rs560149181	3121	dbSNP
rs1345622615	3126	dbSNP
rs1016508194	3131	dbSNP
rs778822977	3136	dbSNP
rs1487441851	3140	dbSNP
rs1167483525	3146	dbSNP
rs116529321	3149	dbSNP
rs1369885193	3151	dbSNP
rs1430729128	3154	dbSNP
rs1197199966	3155	dbSNP
rs1377599564	3155	dbSNP
rs1466987384	3156	dbSNP
rs989232775	3163	dbSNP
rs1358029243	3166	dbSNP
rs1418720638	3166	dbSNP
rs954964677	3168	dbSNP
rs1363619663	3170	dbSNP
rs572083674	3179	dbSNP
rs755041568	3180	dbSNP
rs1331656001	3184	dbSNP
rs1030627148	3185	dbSNP
rs1025073634	3187	dbSNP
rs1351510278	3204	dbSNP
rs1216175560	3205	dbSNP
rs1014124417	3212	dbSNP
rs759893247	3216	dbSNP
rs1187959872	3233	dbSNP
rs563372063	3240	dbSNP
rs555323561	3241	dbSNP
rs571903499	3253	dbSNP

- Cell, 2010

RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.

- Genes & development, 2011

MicroRNAs are important regulators in many cellular processes, including stem cell self-renewal. Recent studies demonstrated their function as pluripotency factors with the capacity for somatic cell reprogramming. However, their role in human embryonic stem (ES) cells (hESCs) remains poorly understood, partially due to the lack of genome-wide strategies to identify their targets. Here, we performed comprehensive microRNA profiling in hESCs and in purified neural and mesenchymal derivatives. Using a combination of AGO cross-linking and microRNA perturbation experiments, together with computational prediction, we identified the targets of the miR-302/367 cluster, the most abundant microRNAs in hESCs. Functional studies identified novel roles of miR-302/367 in maintaining pluripotency and regulating hESC differentiation. We show that in addition to its role in TGF-beta signaling, miR-302/367 promotes bone morphogenetic protein (BMP) signaling by targeting BMP inhibitors TOB2, DAZAP2, and SLAIN1. This study broadens our understanding of microRNA function in hESCs and is a valuable resource for future studies in this area.