miRTarBase - #MIRT527851


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pre-miRNA Information
pre-miRNA hsa-mir-3689e   
Genomic Coordinates chr9: 134850570 - 134850641
Description Homo sapiens miR-3689e stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-3689e
Sequence 7| UGUGAUAUCAUGGUUCCUGGGA |28
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs796680971 2 dbSNP
rs1260021280 4 dbSNP
rs951515835 6 dbSNP
rs1244734523 9 dbSNP
rs1286185090 10 dbSNP
rs922384128 14 dbSNP
rs1485140592 16 dbSNP
Putative Targets

Gene Information
Gene Symbol SMOC1   
Synonyms OAS
Description SPARC related modular calcium binding 1
Transcript NM_001034852   
Other Transcripts NM_022137   
Expression
Putative miRNA Targets on SMOC1
3'UTR of SMOC1
(miRNA target sites are highlighted)		 
>SMOC1|NM_001034852|3'UTR
   1 GGAGCAGAAAACCCAAGGGCAGGTGGAGAGTCCAGGGAGGCAGGATGGATCACCAGACACCTAACCTTCAGCGTTGCCCA
  81 TGGCCCTGCCACATCCCGTGTAACATAAGTGGTGCCCACCATGTTTGCACTTTTAATAACTCTTACTTGCGTGTTTTGTT
 161 TTTGGTTTCATTTTAAAACACCAATATCTAATACCACAGTGGGAAAAGGAAAGGGAAGAAAGACTTTATTCTCTCTCTTA
 241 TTGTAAGTTTTTGGATCTGCTACTGACAACTTTTAGAGGGTTTTGGGGGGGTGGGGGAGGGTGTTGTTGGGGCTGAGAAG
 321 AAAGAGATTTATATGCTGTATATAAATATATATGTAAATTGTATAGTTCTTTTGTACAGGCATTGGCATTGCTGTTTGTT
 401 TATTTCTCTCCCTCTGCCTGCTGTGGGTGGTGGGCACTCTGGACACATAGTCCAGCTTTCTAAAATCCAGGACTCTATCC
 481 TGGGCCTACTAAACTTCTGTTTGGAGACTGACCCTTGTGTATAAAGACGGGAGTCCTGCAATTGTACTGCGGACTCCACG
 561 AGTTCTTTTCTGGTGGGAGGACTATATTGCCCCATGCCATTAGTTGTCAAAATTGATAAGTCACTTGGCTCTCGGCCTTG
 641 TCCAGGGAGGTTGGGCTAAGGAGAGATGGAAACTGCCCTGGGAGAGGAAGGGAGTCCAGATCCCATGAATAGCCCACACA
 721 GGTACCGGCTCTCAGAGGGTCCGTGCATTCCTGCTCTCCGGACCCCCAAAGGGCCCAGCATTGGTGGGTGCACCAGTATC
 801 TTAGTGACCCTCGGAGCAAATTATCCACAAAGGATTTGCATTACGTCACTCGAAACGTTTTCATCCATGCTTAGCATCTA
 881 CTCTGTATAACGCATGAGAGGGGAGGCAAAGAAGAAAAAGACACACAGAAGGGCCTTTAAAAAAGTAGATATTTAATATC
 961 TAAGCAGGGGAGGGGACAGGACAGAAAGCCTGCACTGAGGGGTGCGGTGCCAACAGGGAAACTCTTCACCTCCCTGCAAA
1041 CCTACCAGTGAGGCTCCCAGAGACGCAGCTGTCTCAGTGCCAGGGGCAGATTGGGTGTGACCTCTCCACTCCTCCATCTC
1121 CTGCTGTTGTCCTAGTGGCTATCACAGGCCTGGGTGGGTGGGTTGGGGGAGGTGTCAGTCACCTTGTTGGTAACACTAAA
1201 GTTGTTTTGTTGGTTTTTTAAAAACCCAATACTGAGGTTCTTCCTGTTCCCTCAAGTTTTCTTATGGGCTTCCAGGCTTT
1281 AAGCTAATTCCAGAAGTAAAACTGATCTTGGGTTTCCTATTCTGCCTCCCCTAGAAGGGCAGGGGTGATAACCCAGCTAC
1361 AGGGAAATCCCGGCCCAGCTTTCCACAGGCATCACAGGCATCTTCCGCGGATTCTAGGGTGGGCTGCCCAGCCTTCTGGT
1441 CTGAGGCGCAGCTCCCTCTGCCCAGGTGCTGTGCCTATTCAAGTGGCCTTCAGGCAGAGCAGCAAGTGGCCCTTAGCGCC
1521 CCTTCCCATAAGCAGCTGTGGTGGCAGTGAGGGAGGTTGGGTAGCCCTGGACTGGTCCCCTCCTCAGATCACCCTTGCAA
1601 ATCTGGCCTCATCTTGTATTCCAACCCGACATCCCTAAAAGTACCTCCACCCGTTCCGGGTCTGGAAGGCGTTGGCACCA
1681 CAAGCACTGTCCCTGTGGGAGGAGCACAACCTTCTCGGGACAGGATCTGATGGGGTCTTGGGCTAAAGGAGGTCCCTGCT
1761 GTCCTGGAGAAAGTCCTAGAGGTTATCTCAGGAATGACTGGTGGCCCTGCCCCAACGTGGAAAGGTGGGAAGGAAGCCTT
1841 CTCCCATTAGCCCCAATGAGAGAACTCAACGTGCCGGAGCTGAGTGGGCCTTGCACGAGACACTGGCCCCACTTTCAGGC
1921 CTGGAGGAAGCATGCACACATGGAGACGGCGCCTGCCTGTAGATGTTTGGATCTTCGAGATCTCCCCAGGCATCTTGTCT
2001 CCCACAGGATCGTGTGTGTAGGTGGTGTTGTGTGGTTTTCCTTTGTGAAGGAGAGAGGGAAACTATTTGTAGCTTGTTTT
2081 ATAAAAAATAAAAAATGGGTAAATCTTGAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' agGGU-CCUUGGUACUA--UAGUGu 5'
            ||| |||: || |||  ||||| 
Target 5' gtCCAGGGAGGCAGGATGGATCACc 3'
 30 - 54 132.00 -17.90
2 
miRNA  3' agGGUCCUUGGUACUAUAGUGu 5'
            |||  | |:|  ||| ||| 
Target 5' caCCAATATCTA--ATACCACa 3'
 179 - 198 120.00 -7.60
3 
miRNA  3' aggguccuugguacuAUAGUGu 5'
                         |||||| 
Target 5' tgttgtcctagtggcTATCACa 3'
 1125 - 1146 120.00 -13.30
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
1179798 81 ClinVar
COSM7894425 1 COSMIC
COSN31498861 14 COSMIC
COSN26995828 27 COSMIC
COSN30471586 38 COSMIC
COSN30474649 41 COSMIC
COSN30473617 44 COSMIC
COSN30180704 52 COSMIC
COSN30523177 55 COSMIC
COSN30109137 59 COSMIC
COSN30493640 73 COSMIC
COSN7025247 74 COSMIC
COSN30450005 80 COSMIC
COSN510799 81 COSMIC
COSN30758225 84 COSMIC
COSN31566862 86 COSMIC
COSN30186935 87 COSMIC
COSN30468626 97 COSMIC
COSN30455479 98 COSMIC
COSN30101405 107 COSMIC
COSN17132580 110 COSMIC
COSN30105495 157 COSMIC
COSN30162191 170 COSMIC
COSN31525873 185 COSMIC
COSN20085335 189 COSMIC
COSN8387149 238 COSMIC
COSN19507632 399 COSMIC
COSN31961000 529 COSMIC
COSN8156495 715 COSMIC
COSN20981518 827 COSMIC
COSN8848924 846 COSMIC
COSN5172170 899 COSMIC
COSN26774337 946 COSMIC
COSN6257547 1259 COSMIC
COSN23498266 1408 COSMIC
COSN8156496 1409 COSMIC
COSN15062860 1519 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs751567810 1 dbSNP
rs1354562365 2 dbSNP
rs1211820190 11 dbSNP
rs1291792043 13 dbSNP
rs1468707398 14 dbSNP
rs1301687926 15 dbSNP
rs760656651 15 dbSNP
rs1187858887 16 dbSNP
rs566181977 19 dbSNP
rs201525786 20 dbSNP
rs770017964 23 dbSNP
rs368841209 24 dbSNP
rs936350059 26 dbSNP
rs1456090383 27 dbSNP
rs749646389 28 dbSNP
rs769106450 29 dbSNP
rs774707485 39 dbSNP
rs373029308 43 dbSNP
rs949190906 45 dbSNP
rs770497921 49 dbSNP
rs1465301406 62 dbSNP
rs754560347 66 dbSNP
rs1464704561 69 dbSNP
rs184678642 73 dbSNP
rs370194954 74 dbSNP
rs7152085 81 dbSNP
rs886293554 84 dbSNP
rs1378933156 92 dbSNP
rs1027609797 96 dbSNP
rs1440913141 98 dbSNP
rs1004676638 99 dbSNP
rs1012758803 118 dbSNP
rs77498272 122 dbSNP
rs757925210 123 dbSNP
rs1212703307 124 dbSNP
rs1337857913 128 dbSNP
rs1220069311 135 dbSNP
rs898486266 138 dbSNP
rs1278366864 139 dbSNP
rs1240780568 141 dbSNP
rs1379073045 142 dbSNP
rs574982474 151 dbSNP
rs995508330 152 dbSNP
rs1028526199 163 dbSNP
rs536000675 169 dbSNP
rs1401713909 178 dbSNP
rs954260656 181 dbSNP
rs554318128 182 dbSNP
rs1008480736 185 dbSNP
rs924263028 186 dbSNP
rs1261107998 195 dbSNP
rs777615788 202 dbSNP
rs868049820 204 dbSNP
rs1489279193 210 dbSNP
rs189175828 214 dbSNP
rs966914838 219 dbSNP
rs1424675964 220 dbSNP
rs1422761827 223 dbSNP
rs575114117 230 dbSNP
rs978232692 232 dbSNP
rs1379192675 238 dbSNP
rs1487138539 238 dbSNP
rs1435251804 242 dbSNP
rs990137929 244 dbSNP
rs1032115560 248 dbSNP
rs957688660 250 dbSNP
rs776064218 257 dbSNP
rs1352692851 259 dbSNP
rs1263642792 268 dbSNP
rs1242608913 271 dbSNP
rs1234859645 278 dbSNP
rs546239570 282 dbSNP
rs1273546369 285 dbSNP
rs1349761805 285 dbSNP
rs1338771028 286 dbSNP
rs990518321 288 dbSNP
rs1298307921 290 dbSNP
rs1366445041 292 dbSNP
rs1050571121 293 dbSNP
rs1303859432 299 dbSNP
rs1313214673 300 dbSNP
rs912084919 302 dbSNP
rs944778604 305 dbSNP
rs916253961 307 dbSNP
rs897825877 308 dbSNP
rs1489574533 311 dbSNP
rs759053173 313 dbSNP
rs1265103537 316 dbSNP
rs1209149135 318 dbSNP
rs1357045622 321 dbSNP
rs1273859492 336 dbSNP
rs930662066 339 dbSNP
rs1277842360 340 dbSNP
rs1431849092 351 dbSNP
rs564499094 354 dbSNP
rs1328576430 357 dbSNP
rs1322055041 360 dbSNP
rs1246249440 362 dbSNP
rs1487609208 363 dbSNP
rs1392139900 374 dbSNP
rs949260887 380 dbSNP
rs1193207520 387 dbSNP
rs1269183202 392 dbSNP
rs1049413267 403 dbSNP
rs11540035 407 dbSNP
rs1013143002 420 dbSNP
rs1476220886 431 dbSNP
rs907688091 434 dbSNP
rs1197957997 441 dbSNP
rs1452089434 443 dbSNP
rs1254843084 444 dbSNP
rs1215598462 447 dbSNP
rs907066593 448 dbSNP
rs1257601037 450 dbSNP
rs770876370 451 dbSNP
rs1378356157 454 dbSNP
rs1037522592 458 dbSNP
rs898621535 466 dbSNP
rs1421496841 489 dbSNP
rs1159159294 496 dbSNP
rs931406422 499 dbSNP
rs1031465057 502 dbSNP
rs1398899743 508 dbSNP
rs1331515887 512 dbSNP
rs1411262648 512 dbSNP
rs1399682021 514 dbSNP
rs1433839089 517 dbSNP
rs1294864074 518 dbSNP
rs957221781 523 dbSNP
rs879530920 526 dbSNP
rs889800488 529 dbSNP
rs557738546 530 dbSNP
rs1019891775 532 dbSNP
rs1237636777 540 dbSNP
rs1205362510 542 dbSNP
rs989840628 543 dbSNP
rs902661508 545 dbSNP
rs1022945714 547 dbSNP
rs953637025 548 dbSNP
rs986374163 551 dbSNP
rs912053158 552 dbSNP
rs1376861381 553 dbSNP
rs1356438375 556 dbSNP
rs944912860 560 dbSNP
rs45447998 561 dbSNP
rs1032085419 563 dbSNP
rs1333106769 571 dbSNP
rs111757119 572 dbSNP
rs1377035881 575 dbSNP
rs547940516 581 dbSNP
rs1156686810 582 dbSNP
rs930609095 591 dbSNP
rs372675264 592 dbSNP
rs1177810347 598 dbSNP
rs559830945 600 dbSNP
rs1471202107 601 dbSNP
rs990588537 602 dbSNP
rs1049080582 617 dbSNP
rs1187085367 618 dbSNP
rs1266188585 618 dbSNP
rs1282870534 629 dbSNP
rs1023278652 631 dbSNP
rs970410772 634 dbSNP
rs982419249 635 dbSNP
rs1177756021 636 dbSNP
rs1045715506 646 dbSNP
rs907033931 647 dbSNP
rs1415017637 652 dbSNP
rs749531821 665 dbSNP
rs907827605 667 dbSNP
rs1441464055 673 dbSNP
rs527413867 674 dbSNP
rs1412998714 676 dbSNP
rs1161213137 679 dbSNP
rs1403587086 680 dbSNP
rs1411711748 700 dbSNP
rs1164352215 702 dbSNP
rs1475644494 706 dbSNP
rs1403030846 710 dbSNP
rs1031391405 712 dbSNP
rs1191907787 718 dbSNP
rs182143181 727 dbSNP
rs111784304 728 dbSNP
rs1218549766 730 dbSNP
rs761838383 734 dbSNP
rs533243051 743 dbSNP
rs59918631 744 dbSNP
rs1336438423 755 dbSNP
rs144239370 760 dbSNP
rs78968793 761 dbSNP
rs1362378316 768 dbSNP
rs1290482055 773 dbSNP
rs966146301 774 dbSNP
rs944076580 775 dbSNP
rs972216517 781 dbSNP
rs184347786 783 dbSNP
rs45445899 787 dbSNP
rs1325246492 797 dbSNP
rs1443542373 799 dbSNP
rs45486993 802 dbSNP
rs1168813010 809 dbSNP
rs930728988 811 dbSNP
rs902798678 813 dbSNP
rs867799717 814 dbSNP
rs1000192835 816 dbSNP
rs1213701527 823 dbSNP
rs915908141 827 dbSNP
rs1032490097 829 dbSNP
rs146575108 837 dbSNP
rs761131829 841 dbSNP
rs928545547 844 dbSNP
rs1204962640 845 dbSNP
rs1023413051 846 dbSNP
rs535688780 851 dbSNP
rs554381260 852 dbSNP
rs1003246708 853 dbSNP
rs572653180 869 dbSNP
rs1052937598 877 dbSNP
rs892988366 884 dbSNP
rs1461646506 887 dbSNP
rs1015013338 892 dbSNP
rs961950128 895 dbSNP
rs763918288 897 dbSNP
rs973311492 901 dbSNP
rs1394941889 904 dbSNP
rs1011317524 914 dbSNP
rs1476457017 917 dbSNP
rs2273780 928 dbSNP
rs953240326 930 dbSNP
rs985489528 932 dbSNP
rs1480726049 960 dbSNP
rs911345783 968 dbSNP
rs1477288061 969 dbSNP
rs539971396 971 dbSNP
rs944028497 975 dbSNP
rs1207680865 976 dbSNP
rs1189335336 983 dbSNP
rs889408260 990 dbSNP
rs1007854528 991 dbSNP
rs1236402267 997 dbSNP
rs766736257 1000 dbSNP
rs1307155159 1001 dbSNP
rs1390919167 1003 dbSNP
rs369843484 1004 dbSNP
rs923939846 1006 dbSNP
rs754145236 1009 dbSNP
rs1410812891 1017 dbSNP
rs1464782021 1026 dbSNP
rs966283713 1030 dbSNP
rs1333953648 1031 dbSNP
rs1437100828 1037 dbSNP
rs759884939 1038 dbSNP
rs993736031 1040 dbSNP
rs1357909286 1046 dbSNP
rs1180412337 1047 dbSNP
rs1054069926 1048 dbSNP
rs139737105 1051 dbSNP
rs1252158698 1054 dbSNP
rs1012460964 1059 dbSNP
rs751429988 1064 dbSNP
rs952348862 1065 dbSNP
rs576404999 1066 dbSNP
rs984893234 1073 dbSNP
rs1212821692 1076 dbSNP
rs1351357144 1078 dbSNP
rs1216890795 1083 dbSNP
rs45527633 1086 dbSNP
rs1238344564 1087 dbSNP
rs906250360 1092 dbSNP
rs1003708607 1094 dbSNP
rs1014570592 1096 dbSNP
rs1280266782 1098 dbSNP
rs375761979 1110 dbSNP
rs994697617 1114 dbSNP
rs1214891549 1115 dbSNP
rs915983915 1123 dbSNP
rs1277713286 1131 dbSNP
rs1027549817 1132 dbSNP
rs953211687 1133 dbSNP
rs543752201 1141 dbSNP
rs562648261 1149 dbSNP
rs1257586093 1151 dbSNP
rs911721477 1155 dbSNP
rs899145564 1156 dbSNP
rs45622332 1157 dbSNP
rs1454817446 1159 dbSNP
rs1190880464 1160 dbSNP
rs1425270986 1161 dbSNP
rs45576440 1163 dbSNP
rs1411670321 1165 dbSNP
rs995468069 1165 dbSNP
rs45542132 1167 dbSNP
rs1423596597 1179 dbSNP
rs981454884 1181 dbSNP
rs928513828 1183 dbSNP
rs1260843935 1188 dbSNP
rs1313962407 1196 dbSNP
rs934550366 1198 dbSNP
rs977255012 1214 dbSNP
rs189236198 1215 dbSNP
rs1334389975 1220 dbSNP
rs1300141575 1221 dbSNP
rs866346218 1225 dbSNP
rs1338886894 1227 dbSNP
rs116283028 1230 dbSNP
rs752367262 1241 dbSNP
rs915532720 1255 dbSNP
rs1291244724 1258 dbSNP
rs1007823639 1262 dbSNP
rs1418047225 1272 dbSNP
rs948295138 1276 dbSNP
rs1166625896 1285 dbSNP
rs1476672650 1309 dbSNP
rs1045218956 1311 dbSNP
rs1274022417 1313 dbSNP
rs1040667606 1317 dbSNP
rs1193690107 1317 dbSNP
rs1265221615 1330 dbSNP
rs1211823376 1331 dbSNP
rs1468101253 1339 dbSNP
rs896857246 1341 dbSNP
rs906714311 1343 dbSNP
rs527474164 1344 dbSNP
rs1215785825 1348 dbSNP
rs61612924 1360 dbSNP
rs1269956742 1370 dbSNP
rs1228646147 1371 dbSNP
rs1036548386 1372 dbSNP
rs1301888769 1373 dbSNP
rs757865112 1375 dbSNP
rs3742912 1379 dbSNP
rs1006808541 1380 dbSNP
rs1327376921 1384 dbSNP
rs1027520428 1390 dbSNP
rs1263277086 1392 dbSNP
rs1168242354 1401 dbSNP
rs888998678 1407 dbSNP
rs3742913 1408 dbSNP
rs541985823 1409 dbSNP
rs1007432496 1410 dbSNP
rs1479172808 1418 dbSNP
rs1018756054 1419 dbSNP
rs966301414 1422 dbSNP
rs1436244318 1423 dbSNP
rs976845776 1424 dbSNP
rs1035684057 1425 dbSNP
rs1380173938 1426 dbSNP
rs751544588 1428 dbSNP
rs1234159114 1431 dbSNP
rs3742914 1433 dbSNP
rs989449162 1439 dbSNP
rs538933648 1449 dbSNP
rs1385846358 1456 dbSNP
rs948262563 1466 dbSNP
rs1411361520 1467 dbSNP
rs557274944 1477 dbSNP
rs1172825030 1478 dbSNP
rs145798773 1486 dbSNP
rs943778279 1488 dbSNP
rs148985334 1492 dbSNP
rs781285346 1496 dbSNP
rs1442773044 1517 dbSNP
rs769599437 1518 dbSNP
rs1232461211 1519 dbSNP
rs896826239 1520 dbSNP
rs929636285 1523 dbSNP
rs867329536 1526 dbSNP
rs79460286 1529 dbSNP
rs888039633 1532 dbSNP
rs930402818 1539 dbSNP
rs1350698221 1550 dbSNP
rs1349312899 1558 dbSNP
rs1279694018 1582 dbSNP
rs1443885666 1584 dbSNP
rs1006367123 1593 dbSNP
rs80262145 1601 dbSNP
rs566315460 1607 dbSNP
rs1469552746 1614 dbSNP
rs1316154940 1615 dbSNP
rs147757192 1617 dbSNP
rs1400107993 1623 dbSNP
rs1407305008 1627 dbSNP
rs1194633031 1628 dbSNP
rs1471250440 1629 dbSNP
rs1237994186 1632 dbSNP
rs558285075 1634 dbSNP
rs34130244 1647 dbSNP
rs888799261 1653 dbSNP
rs1007419347 1654 dbSNP
rs558808751 1658 dbSNP
rs956032053 1659 dbSNP
rs1364892271 1660 dbSNP
rs901674194 1661 dbSNP
rs1332167318 1665 dbSNP
rs141113901 1670 dbSNP
rs537064652 1671 dbSNP
rs1400733979 1672 dbSNP
rs1161563597 1673 dbSNP
rs1021516505 1679 dbSNP
rs969020427 1680 dbSNP
rs1319017794 1681 dbSNP
rs1458888326 1685 dbSNP
rs536812912 1705 dbSNP
rs1164460432 1710 dbSNP
rs761185178 1711 dbSNP
rs989584788 1713 dbSNP
rs181239668 1717 dbSNP
rs1375954577 1718 dbSNP
rs911049578 1735 dbSNP
rs1217228830 1736 dbSNP
rs573936416 1743 dbSNP
rs1444328730 1749 dbSNP
rs372662734 1752 dbSNP
rs1272056525 1758 dbSNP
rs541763428 1762 dbSNP
rs1213929935 1764 dbSNP
rs1336553404 1771 dbSNP
rs575549912 1775 dbSNP
rs1293112944 1777 dbSNP
rs969404902 1783 dbSNP
rs981027326 1795 dbSNP
rs1362487171 1796 dbSNP
rs1271868891 1797 dbSNP
rs1336310452 1799 dbSNP
rs1368869179 1800 dbSNP
rs1325353250 1803 dbSNP
rs1462143629 1807 dbSNP
rs1351859774 1808 dbSNP
rs1168730522 1811 dbSNP
rs943914452 1812 dbSNP
rs976434680 1815 dbSNP
rs918343759 1816 dbSNP
rs571912935 1817 dbSNP
rs939525654 1818 dbSNP
rs1336454663 1819 dbSNP
rs1214004696 1830 dbSNP
rs1048554708 1846 dbSNP
rs888143815 1847 dbSNP
rs1203482190 1851 dbSNP
rs1307844637 1853 dbSNP
rs942267255 1854 dbSNP
rs1044706639 1857 dbSNP
rs545555700 1865 dbSNP
rs919428630 1866 dbSNP
rs930370080 1871 dbSNP
rs1441775951 1874 dbSNP
rs1048809014 1876 dbSNP
rs1296683373 1877 dbSNP
rs888764795 1880 dbSNP
rs1355478065 1881 dbSNP
rs1420159978 1884 dbSNP
rs1475652462 1885 dbSNP
rs1433380765 1893 dbSNP
rs1170169842 1894 dbSNP
rs1173639720 1895 dbSNP
rs1434407848 1896 dbSNP
rs891891876 1898 dbSNP
rs943069117 1900 dbSNP
rs1040284183 1908 dbSNP
rs901723675 1920 dbSNP
rs1022029078 1921 dbSNP
rs998788180 1928 dbSNP
rs1208494739 1933 dbSNP
rs1053341113 1938 dbSNP
rs1347009185 1941 dbSNP
rs1280963610 1943 dbSNP
rs1235041595 1945 dbSNP
rs1305046693 1948 dbSNP
rs892989312 1948 dbSNP
rs564044129 1949 dbSNP
rs1022410387 1951 dbSNP
rs969373840 1952 dbSNP
rs1002647654 1954 dbSNP
rs1413322907 1958 dbSNP
rs1375309889 1960 dbSNP
rs1035034851 1962 dbSNP
rs1468088736 1965 dbSNP
rs1356877445 1972 dbSNP
rs147982176 1977 dbSNP
rs1419250832 1988 dbSNP
rs531411149 2002 dbSNP
rs1315710105 2003 dbSNP
rs1311780253 2004 dbSNP
rs972360643 2012 dbSNP
rs976568835 2015 dbSNP
rs1202107190 2016 dbSNP
rs919397506 2022 dbSNP
rs1483189827 2025 dbSNP
rs952238646 2026 dbSNP
rs984504287 2027 dbSNP
rs750458860 2029 dbSNP
rs185808601 2032 dbSNP
rs1290456656 2033 dbSNP
rs141666125 2044 dbSNP
rs1193084751 2066 dbSNP
rs1355218132 2068 dbSNP
rs1294330565 2073 dbSNP
rs1398282155 2076 dbSNP
rs943141991 2083 dbSNP
rs1430570161 2090 dbSNP
rs528885359 2092 dbSNP
rs548153484 2100 dbSNP
rs1453860790 2109 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions hESCs (WA-09)
Disease 64093.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in SRR359787. RNA binding protein: AGO2. Condition:4-thiouridine ...

- Lipchina I; Elkabetz Y; Hafner M; Sheridan et al., 2011, Genes & development.

Article - Lipchina I; Elkabetz Y; Hafner M; Sheridan et al.
- Genes & development, 2011
MicroRNAs are important regulators in many cellular processes, including stem cell self-renewal. Recent studies demonstrated their function as pluripotency factors with the capacity for somatic cell reprogramming. However, their role in human embryonic stem (ES) cells (hESCs) remains poorly understood, partially due to the lack of genome-wide strategies to identify their targets. Here, we performed comprehensive microRNA profiling in hESCs and in purified neural and mesenchymal derivatives. Using a combination of AGO cross-linking and microRNA perturbation experiments, together with computational prediction, we identified the targets of the miR-302/367 cluster, the most abundant microRNAs in hESCs. Functional studies identified novel roles of miR-302/367 in maintaining pluripotency and regulating hESC differentiation. We show that in addition to its role in TGF-beta signaling, miR-302/367 promotes bone morphogenetic protein (BMP) signaling by targeting BMP inhibitors TOB2, DAZAP2, and SLAIN1. This study broadens our understanding of microRNA function in hESCs and is a valuable resource for future studies in this area.
LinkOut: [PMID: 22012620]
CLIP-seq Support 1 for dataset SRR359787
Method / RBP PAR-CLIP / AGO2
Cell line / Condition hESCs (WA-09) / 4-thiouridine, RNase T1
Location of target site ENST00000381280.4 | 3UTR | CAGGCCUGGGUGGGUGGGUUGGGGGA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22012620 / SRX103431
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
45 hsa-miR-3689e Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT112233 MDM4 MDM4, p53 regulator 2 2
MIRT188658 FAM76A family with sequence similarity 76 member A 2 2
MIRT200913 ZNF264 zinc finger protein 264 2 4
MIRT210597 KBTBD8 kelch repeat and BTB domain containing 8 2 6
MIRT299209 CSRNP3 cysteine and serine rich nuclear protein 3 2 2
MIRT317526 SLC39A7 solute carrier family 39 member 7 2 2
MIRT355852 SGMS2 sphingomyelin synthase 2 2 4
MIRT443050 THRB thyroid hormone receptor beta 2 2
MIRT446629 SDC3 syndecan 3 2 2
MIRT449407 TRIM5 tripartite motif containing 5 2 2
MIRT463559 ZBTB39 zinc finger and BTB domain containing 39 2 6
MIRT465701 TNFAIP1 TNF alpha induced protein 1 2 2
MIRT472686 MYCBP MYC binding protein 2 4
MIRT493285 LNPEP leucyl and cystinyl aminopeptidase 2 2
MIRT499336 RAB25 RAB25, member RAS oncogene family 2 2
MIRT501721 OVOL1 ovo like transcriptional repressor 1 2 2
MIRT507975 BCL2L13 BCL2 like 13 2 4
MIRT511809 HDGF heparin binding growth factor 2 6
MIRT516709 PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma 2 4
MIRT527851 SMOC1 SPARC related modular calcium binding 1 2 2
MIRT531284 SLC7A7 solute carrier family 7 member 7 2 2
MIRT531892 INVS inversin 2 8
MIRT536805 HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 2 2
MIRT537805 EFNB2 ephrin B2 2 4
MIRT544333 LPGAT1 lysophosphatidylglycerol acyltransferase 1 2 2
MIRT547140 PGM3 phosphoglucomutase 3 2 2
MIRT547427 MED4 mediator complex subunit 4 2 2
MIRT563352 ZNF181 zinc finger protein 181 2 2
MIRT564847 ZBED3 zinc finger BED-type containing 3 2 2
MIRT566424 PIGA phosphatidylinositol glycan anchor biosynthesis class A 2 2
MIRT572510 KIAA0232 KIAA0232 2 2
MIRT574680 HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 2 2
MIRT608818 ONECUT3 one cut homeobox 3 2 6
MIRT608884 CLIC6 chloride intracellular channel 6 2 2
MIRT608957 GIMAP1 GTPase, IMAP family member 1 2 4
MIRT609010 HPS3 HPS3, biogenesis of lysosomal organelles complex 2 subunit 1 2 2
MIRT641429 SCUBE3 signal peptide, CUB domain and EGF like domain containing 3 2 2
MIRT661839 ZNF587B zinc finger protein 587B 2 2
MIRT690649 RPF2 ribosome production factor 2 homolog 2 2
MIRT704617 CLIP1 CAP-Gly domain containing linker protein 1 2 2
MIRT708712 PTPLAD2 3-hydroxyacyl-CoA dehydratase 4 1 1
MIRT710661 CSTF2T cleavage stimulation factor subunit 2 tau variant 2 2
MIRT711258 TPCN2 two pore segment channel 2 2 2
MIRT714647 FSTL1 follistatin like 1 2 2
MIRT718516 COL19A1 collagen type XIX alpha 1 chain 2 2

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