miRTarBase - #MIRT528038


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pre-miRNA Information
pre-miRNA hsa-mir-4301   
Genomic Coordinates chr11: 113450023 - 113450088
Description Homo sapiens miR-4301 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4301
Sequence 11| UCCCACUACUUCACUUGUGA |30
Evidence Experimental
Experiments SOLiD
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs184176277 2 dbSNP
rs1191324913 13 dbSNP
rs1369198005 15 dbSNP
rs1036973189 16 dbSNP
rs944900541 18 dbSNP
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol WT1   
Synonyms AWT1, EWS-WT1, GUD, NPHS4, WAGR, WIT-2, WT33
Description Wilms tumor 1
Transcript NM_000378   
Other Transcripts NM_024424 , NM_024426   
Expression
Putative miRNA Targets on WT1
3'UTR of WT1
(miRNA target sites are highlighted)		 
>WT1|NM_000378|3'UTR
   1 GGGGTCTCCCTCGGGGACCGTTCAGTGTCCCAGGCAGCACAGTGTGTGAACTGCTTTCAAGTCTGACTCTCCACTCCTCC
  81 TCACTAAAAAGGAAACTTCAGTTGATCTTCTTCATCCAACTTCCAAGACAAGATACCGGTGCTTCTGGAAACTACCAGGT
 161 GTGCCTGGAAGAGTTGGTCTCTGCCCTGCCTACTTTTAGTTGACTCACAGGCCCTGGAGAAGCAGCTAACAATGTCTGGT
 241 TAGTTAAAAGCCCATTGCCATTTGGTGTGGATTTTCTACTGTAAGAAGAGCCATAGCTGATCATGTCCCCCTGACCCTTC
 321 CCTTCTTTTTTTATGCTCGTTTTCGCTGGGGATGGAATTATTGTACCATTTTCTATCATGGAATATTTATAGGCCAGGGC
 401 ATGTGTATGTGTCTGCTAATGTAAACTTTGTCATGGTTTCCATTTACTAACAGCAACAGCAAGAAATAAATCAGAGAGCA
 481 AGGCATCGGGGGTGAATCTTGTCTAACATTCCCGAGGTCAGCCAGGCTGCTAACCTGGAAAGCAGGATGTAGTTCTGCCA
 561 GGCAACTTTTAAAGCTCATGCATTTCAAGCAGCTGAAGAAAAAATCAGAACTAACCAGTACCTCTGTATAGAAATCTAAA
 641 AGAATTTTACCATTCAGTTAATTCAATGTGAACACTGGCACACTGCTCTTAAGAAACTATGAAGATCTGAGATTTTTTTG
 721 TGTATGTTTTTGACTCTTTTGAGTGGTAATCATATGTGTCTTTATAGATGTACATACCTCCTTGCACAAATGGAGGGGAA
 801 TTCATTTTCATCACTGGGAGTGTCCTTAGTGTATAAAAACCATGCTGGTATATGGCTTCAAGTTGTAAAAATGAAAGTGA
 881 CTTTAAAAGAAAATAGGGGATGGTCCAGGATCTCCACTGATAAGACTGTTTTTAAGTAACTTAAGGACCTTTGGGTCTAC
 961 AAGTATATGTGAAAAAAATGAGACTTACTGGGTGAGGAAATCCATTGTTTAAAGATGGTCGTGTGTGTGTGTGTGTGTGT
1041 GTGTGTGTGTGTGTTGTGTTGTGTTTTGTTTTTTAAGGGAGGGAATTTATTATTTACCGTTGCTTGAAATTACTGTGTAA
1121 ATATATGTCTGATAATGATTTGCTCTTTGACAACTAAAATTAGGACTGTATAAGTACTAGATGCATCACTGGGTGTTGAT
1201 CTTACAAGATATTGATGATAACACTTAAAATTGTAACCTGCATTTTTCACTTTGCTCTCAATTAAAGTCTATTCAAAAGG
1281 AAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' agUGUUCACUU--CAUCACCCu 5'
            | || |||:   || |||| 
Target 5' aaAAAAATGAGACTTACTGGGt 3'
 972 - 993 120.00 -5.80
2 
miRNA  3' agugUUCAC-UUCAUCACccu 5'
              :||||    |||||   
Target 5' ctggGAGTGTCCTTAGTGtat 3'
 814 - 834 104.00 -7.12
3 
miRNA  3' agUGUUCACUUCAUCACCcu 5'
            | |||  || ||| ||  
Target 5' ttAAAAG-AAAATAGGGGat 3'
 883 - 901 101.00 -7.10
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
877955 5 ClinVar
877954 12 ClinVar
304417 16 ClinVar
304416 88 ClinVar
879521 100 ClinVar
304415 110 ClinVar
304414 138 ClinVar
304413 159 ClinVar
304412 224 ClinVar
304411 239 ClinVar
304410 267 ClinVar
304409 269 ClinVar
304408 345 ClinVar
304407 354 ClinVar
304406 366 ClinVar
304405 393 ClinVar
304404 460 ClinVar
304403 513 ClinVar
304402 534 ClinVar
304401 542 ClinVar
304400 575 ClinVar
304399 602 ClinVar
304398 611 ClinVar
304397 614 ClinVar
878010 629 ClinVar
304396 666 ClinVar
304395 685 ClinVar
304394 707 ClinVar
304393 741 ClinVar
304392 768 ClinVar
304391 785 ClinVar
304390 820 ClinVar
304389 835 ClinVar
304388 841 ClinVar
304386 864 ClinVar
304387 864 ClinVar
304385 897 ClinVar
304384 903 ClinVar
304383 979 ClinVar
304382 1050 ClinVar
304377 1055 ClinVar
304378 1055 ClinVar
304379 1055 ClinVar
304380 1055 ClinVar
304381 1055 ClinVar
304376 1058 ClinVar
879412 1066 ClinVar
304375 1098 ClinVar
304374 1132 ClinVar
304373 1167 ClinVar
304372 1209 ClinVar
304371 1225 ClinVar
304370 1239 ClinVar
COSN32052536 2 COSMIC
COSN31511111 3 COSMIC
COSN30452934 8 COSMIC
COSN30463064 10 COSMIC
COSN31510580 12 COSMIC
COSN31497344 20 COSMIC
COSN30494022 43 COSMIC
COSN32052956 48 COSMIC
COSN30139209 60 COSMIC
COSN30172937 74 COSMIC
COSN30624384 74 COSMIC
COSN30475713 79 COSMIC
COSN30487661 91 COSMIC
COSN17156025 92 COSMIC
COSN29998792 96 COSMIC
COSN31594402 141 COSMIC
COSN8442574 167 COSMIC
COSN26703281 339 COSMIC
COSN28784866 346 COSMIC
COSN17290845 382 COSMIC
COSN31594723 404 COSMIC
COSN26642592 481 COSMIC
COSN18723933 488 COSMIC
COSN31529925 649 COSMIC
COSN30424595 709 COSMIC
COSN30172821 720 COSMIC
COSN25075294 721 COSMIC
COSN1529230 725 COSMIC
COSN19660431 971 COSMIC
COSN20108126 1021 COSMIC
COSN20108127 1021 COSMIC
COSN20108128 1049 COSMIC
COSN8641513 1057 COSMIC
COSN31517733 1060 COSMIC
COSN20092335 1061 COSMIC
rs5030317 267 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs747197306 1 dbSNP
rs758798048 2 dbSNP
rs1240257854 3 dbSNP
rs750842875 4 dbSNP
rs765743928 5 dbSNP
rs757807247 10 dbSNP
rs77462662 12 dbSNP
rs763645824 13 dbSNP
rs1056721618 15 dbSNP
rs2234594 16 dbSNP
rs927564066 19 dbSNP
rs767103760 20 dbSNP
rs984366138 24 dbSNP
rs1455176857 27 dbSNP
rs759275928 29 dbSNP
rs774104210 30 dbSNP
rs991097424 31 dbSNP
rs376972948 35 dbSNP
rs1331603534 38 dbSNP
rs1186178033 39 dbSNP
rs749213891 42 dbSNP
rs773040516 46 dbSNP
rs1422395057 53 dbSNP
rs1193913917 54 dbSNP
rs1476631211 77 dbSNP
rs1245314067 80 dbSNP
rs563643335 81 dbSNP
rs749749213 84 dbSNP
rs5030315 88 dbSNP
rs1452652735 93 dbSNP
rs757474299 110 dbSNP
rs1162327531 114 dbSNP
rs1406692115 114 dbSNP
rs1414042959 114 dbSNP
rs1275133169 127 dbSNP
rs1369331887 128 dbSNP
rs1196763919 129 dbSNP
rs966701159 137 dbSNP
rs111351882 138 dbSNP
rs1279158437 139 dbSNP
rs770485644 140 dbSNP
rs1357344319 141 dbSNP
rs1230199836 149 dbSNP
rs746218880 159 dbSNP
rs953997384 163 dbSNP
rs1032790030 166 dbSNP
rs1363877593 169 dbSNP
rs995943288 174 dbSNP
rs1435707641 176 dbSNP
rs1028931020 181 dbSNP
rs900441530 192 dbSNP
rs1186607328 206 dbSNP
rs560907250 208 dbSNP
rs5030316 224 dbSNP
rs1389082529 225 dbSNP
rs796522901 234 dbSNP
rs1169824750 238 dbSNP
rs886048226 239 dbSNP
rs1394746712 240 dbSNP
rs1020107898 241 dbSNP
rs1010439193 242 dbSNP
rs1450480642 243 dbSNP
rs895550196 249 dbSNP
rs868155844 260 dbSNP
rs886100767 265 dbSNP
rs5030317 267 dbSNP
rs886048225 269 dbSNP
rs1170996495 276 dbSNP
rs181881769 280 dbSNP
rs1199744336 283 dbSNP
rs1279088777 284 dbSNP
rs905497414 294 dbSNP
rs1423545206 295 dbSNP
rs1190909350 303 dbSNP
rs930364808 309 dbSNP
rs1478651887 310 dbSNP
rs1449592892 311 dbSNP
rs1049129396 312 dbSNP
rs1189961244 313 dbSNP
rs1392674839 314 dbSNP
rs1177313133 326 dbSNP
rs1464987120 332 dbSNP
rs899352795 334 dbSNP
rs1258773117 338 dbSNP
rs544612574 339 dbSNP
rs972909573 344 dbSNP
rs5030318 345 dbSNP
rs1232520737 349 dbSNP
rs1275368080 352 dbSNP
rs886048224 354 dbSNP
rs1346914622 363 dbSNP
rs557682653 365 dbSNP
rs886048223 366 dbSNP
rs537329306 378 dbSNP
rs746694121 379 dbSNP
rs568703873 390 dbSNP
rs777105291 391 dbSNP
rs1310626511 392 dbSNP
rs886048222 393 dbSNP
rs1276255646 401 dbSNP
rs938130766 403 dbSNP
rs1198858686 412 dbSNP
rs772298084 420 dbSNP
rs554888133 429 dbSNP
rs1378685023 436 dbSNP
rs928209846 443 dbSNP
rs1157443228 446 dbSNP
rs1444441326 446 dbSNP
rs982346389 447 dbSNP
rs761025226 453 dbSNP
rs879240964 457 dbSNP
rs535181585 459 dbSNP
rs886048221 460 dbSNP
rs189407871 465 dbSNP
rs1386253975 468 dbSNP
rs979120763 475 dbSNP
rs757906937 476 dbSNP
rs1443928605 486 dbSNP
rs958135207 487 dbSNP
rs1174897720 489 dbSNP
rs1028338011 501 dbSNP
rs575602262 513 dbSNP
rs372622383 514 dbSNP
rs895630432 517 dbSNP
rs1209938024 518 dbSNP
rs765145800 521 dbSNP
rs1397233754 526 dbSNP
rs868546165 534 dbSNP
rs1019321308 541 dbSNP
rs142726499 542 dbSNP
rs1238906532 548 dbSNP
rs754974695 565 dbSNP
rs774867727 571 dbSNP
rs5030319 575 dbSNP
rs79335260 575 dbSNP
rs1025959550 577 dbSNP
rs1161610087 578 dbSNP
rs1328303145 597 dbSNP
rs5030320 602 dbSNP
rs766220081 604 dbSNP
rs550080671 607 dbSNP
rs886048220 611 dbSNP
rs1163934572 613 dbSNP
rs886048219 614 dbSNP
rs996185185 637 dbSNP
rs1211085209 642 dbSNP
rs1307321972 648 dbSNP
rs1350949502 649 dbSNP
rs1411393848 649 dbSNP
rs1054845813 650 dbSNP
rs761903425 652 dbSNP
rs897393675 655 dbSNP
rs1348375203 657 dbSNP
rs374306749 666 dbSNP
rs1244980349 667 dbSNP
rs764209237 669 dbSNP
rs944204990 670 dbSNP
rs1047116378 674 dbSNP
rs1203721346 675 dbSNP
rs1352809169 682 dbSNP
rs886048218 685 dbSNP
rs1307101232 692 dbSNP
rs1179338904 697 dbSNP
rs945630884 699 dbSNP
rs914117881 700 dbSNP
rs763107748 703 dbSNP
rs886048217 707 dbSNP
rs1225026098 713 dbSNP
rs1254456307 714 dbSNP
rs1049846463 720 dbSNP
rs1165671287 720 dbSNP
rs1387221562 724 dbSNP
rs1427895564 732 dbSNP
rs1167928628 734 dbSNP
rs1371063290 735 dbSNP
rs886048216 741 dbSNP
rs1463427035 745 dbSNP
rs1300870507 746 dbSNP
rs1376335993 751 dbSNP
rs1053728782 752 dbSNP
rs1362455979 755 dbSNP
rs1227002852 756 dbSNP
rs1274671942 765 dbSNP
rs886048215 768 dbSNP
rs1343533420 769 dbSNP
rs184847211 774 dbSNP
rs936643491 780 dbSNP
rs886048214 785 dbSNP
rs746314166 792 dbSNP
rs148478722 797 dbSNP
rs969067930 798 dbSNP
rs1390791454 800 dbSNP
rs1230481073 809 dbSNP
rs913167730 814 dbSNP
rs975468471 818 dbSNP
rs1042347 820 dbSNP
rs959873880 826 dbSNP
rs5030322 835 dbSNP
rs886048213 841 dbSNP
rs1338358214 848 dbSNP
rs1001281441 853 dbSNP
rs1433846737 855 dbSNP
rs1297696429 861 dbSNP
rs1381415682 862 dbSNP
rs5030323 864 dbSNP
rs576023116 872 dbSNP
rs1299813964 893 dbSNP
rs5030324 897 dbSNP
rs1026620563 900 dbSNP
rs5030325 903 dbSNP
rs760142967 913 dbSNP
rs1182713275 917 dbSNP
rs1463717575 919 dbSNP
rs962999593 926 dbSNP
rs1248788262 936 dbSNP
rs1486888100 937 dbSNP
rs1189446509 940 dbSNP
rs776814761 949 dbSNP
rs1259360681 950 dbSNP
rs1033467522 951 dbSNP
rs771360373 955 dbSNP
rs1214105801 957 dbSNP
rs891333731 962 dbSNP
rs1261307317 965 dbSNP
rs1049918557 968 dbSNP
rs1292340190 974 dbSNP
rs1367545112 976 dbSNP
rs1241055722 978 dbSNP
rs5030326 979 dbSNP
rs796951581 980 dbSNP
rs1327510386 982 dbSNP
rs932745099 988 dbSNP
rs1001941309 998 dbSNP
rs575035138 1002 dbSNP
rs1233552547 1004 dbSNP
rs925376619 1019 dbSNP
rs906718942 1020 dbSNP
rs1046578742 1021 dbSNP
rs780961917 1024 dbSNP
rs1010121279 1026 dbSNP
rs892728364 1028 dbSNP
rs1276716298 1035 dbSNP
rs1249418711 1045 dbSNP
rs766176703 1048 dbSNP
rs770524174 1048 dbSNP
rs568803808 1050 dbSNP
rs750046431 1050 dbSNP
rs758276052 1050 dbSNP
rs1159495526 1051 dbSNP
rs1163497628 1055 dbSNP
rs1349897202 1055 dbSNP
rs1403194469 1055 dbSNP
rs1406157009 1055 dbSNP
rs1409674451 1055 dbSNP
rs147708114 1055 dbSNP
rs200382866 1055 dbSNP
rs58549495 1055 dbSNP
rs761038390 1055 dbSNP
rs796756898 1055 dbSNP
rs878917290 1055 dbSNP
rs886048212 1055 dbSNP
rs1224710460 1056 dbSNP
rs754104430 1056 dbSNP
rs767995702 1056 dbSNP
rs1272345421 1058 dbSNP
rs886048211 1058 dbSNP
rs1053925651 1060 dbSNP
rs879067084 1061 dbSNP
rs1386132830 1066 dbSNP
rs936717004 1066 dbSNP
rs1291188783 1068 dbSNP
rs1471608214 1075 dbSNP
rs913857886 1077 dbSNP
rs1425972472 1083 dbSNP
rs921258573 1086 dbSNP
rs5030327 1098 dbSNP
rs746578571 1099 dbSNP
rs1429635201 1117 dbSNP
rs5030328 1132 dbSNP
rs566276801 1141 dbSNP
rs1337839736 1163 dbSNP
rs771770230 1167 dbSNP
rs1283811200 1170 dbSNP
rs754404198 1173 dbSNP
rs1383667889 1174 dbSNP
rs1421830071 1179 dbSNP
rs1248234319 1183 dbSNP
rs1272508702 1184 dbSNP
rs979893839 1193 dbSNP
rs919177283 1198 dbSNP
rs5030329 1209 dbSNP
rs1382004056 1210 dbSNP
rs747653324 1212 dbSNP
rs1477395184 1214 dbSNP
rs539117133 1215 dbSNP
rs1446034534 1216 dbSNP
rs1186163890 1219 dbSNP
rs886048210 1225 dbSNP
rs1388945609 1231 dbSNP
rs534396876 1239 dbSNP
rs1206844262 1257 dbSNP
rs1487439885 1261 dbSNP
rs1264350882 1267 dbSNP
rs995623692 1282 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions hESCs (WA-09)
Disease 7490.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in SRR359787. RNA binding protein: AGO2. Condition:4-thiouridine ...

- Lipchina I; Elkabetz Y; Hafner M; Sheridan et al., 2011, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' agugUUCACUUCA-UCACCcu 5'
              |||| |:|| |||||  
Target 5' gugaAAGU-AGGUCAGUGG-- 3'
 		5 - 22
Article - Lipchina I; Elkabetz Y; Hafner M; Sheridan et al.
- Genes & development, 2011
MicroRNAs are important regulators in many cellular processes, including stem cell self-renewal. Recent studies demonstrated their function as pluripotency factors with the capacity for somatic cell reprogramming. However, their role in human embryonic stem (ES) cells (hESCs) remains poorly understood, partially due to the lack of genome-wide strategies to identify their targets. Here, we performed comprehensive microRNA profiling in hESCs and in purified neural and mesenchymal derivatives. Using a combination of AGO cross-linking and microRNA perturbation experiments, together with computational prediction, we identified the targets of the miR-302/367 cluster, the most abundant microRNAs in hESCs. Functional studies identified novel roles of miR-302/367 in maintaining pluripotency and regulating hESC differentiation. We show that in addition to its role in TGF-beta signaling, miR-302/367 promotes bone morphogenetic protein (BMP) signaling by targeting BMP inhibitors TOB2, DAZAP2, and SLAIN1. This study broadens our understanding of microRNA function in hESCs and is a valuable resource for future studies in this area.
LinkOut: [PMID: 22012620]
CLIP-seq Support 1 for dataset SRR359787
Method / RBP PAR-CLIP / AGO2
Cell line / Condition hESCs (WA-09) / 4-thiouridine, RNase T1
Location of target site ENST00000379079.2 | 3UTR | GUGGGUGAAAGUAGGUCAGUGG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22012620 / SRX103431
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
83 hsa-miR-4301 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT081134 LDLR low density lipoprotein receptor 2 4
MIRT090911 ARHGEF26 Rho guanine nucleotide exchange factor 26 2 2
MIRT229436 MECP2 methyl-CpG binding protein 2 2 2
MIRT274717 CPSF6 cleavage and polyadenylation specific factor 6 2 2
MIRT350957 BACH1 BTB domain and CNC homolog 1 2 2
MIRT386722 NUFIP2 NUFIP2, FMR1 interacting protein 2 2 2
MIRT446022 PEX3 peroxisomal biogenesis factor 3 2 2
MIRT481303 ATP5G3 ATP synthase, H+ transporting, mitochondrial Fo complex subunit C3 (subunit 9) 2 14
MIRT483959 ZNF354B zinc finger protein 354B 2 6
MIRT495667 TUBAL3 tubulin alpha like 3 2 2
MIRT496554 TBX15 T-box 15 2 2
MIRT497702 ARL6IP6 ADP ribosylation factor like GTPase 6 interacting protein 6 2 2
MIRT498105 RMND5A required for meiotic nuclear division 5 homolog A 2 2
MIRT512535 SEMA4D semaphorin 4D 2 2
MIRT512556 MFN2 mitofusin 2 2 6
MIRT521465 RABGAP1 RAB GTPase activating protein 1 2 6
MIRT526236 C2orf15 chromosome 2 open reading frame 15 2 2
MIRT526743 HLA-DOB major histocompatibility complex, class II, DO beta 2 2
MIRT527578 BRD7 bromodomain containing 7 2 4
MIRT528038 WT1 Wilms tumor 1 2 2
MIRT528267 GPRIN2 G protein regulated inducer of neurite outgrowth 2 2 2
MIRT528505 HTR7 5-hydroxytryptamine receptor 7 2 4
MIRT528758 RPS27 ribosomal protein S27 2 6
MIRT528999 IPO9 importin 9 2 2
MIRT529701 MRPL30 mitochondrial ribosomal protein L30 2 2
MIRT529781 C17orf82 chromosome 17 open reading frame 82 2 2
MIRT533797 TMEM119 transmembrane protein 119 2 6
MIRT535308 PHF12 PHD finger protein 12 2 2
MIRT535917 MKL2 MKL1/myocardin like 2 2 2
MIRT544892 OSBPL1A oxysterol binding protein like 1A 2 2
MIRT555423 PPIC peptidylprolyl isomerase C 2 2
MIRT562068 KLHL15 kelch like family member 15 2 2
MIRT565623 SLC31A1 solute carrier family 31 member 1 2 2
MIRT565661 SIX1 SIX homeobox 1 2 2
MIRT570138 IL1RL2 interleukin 1 receptor like 2 2 2
MIRT571045 YRDC yrdC N6-threonylcarbamoyltransferase domain containing 2 2
MIRT621232 LMAN1 lectin, mannose binding 1 2 2
MIRT622272 SH3TC2 SH3 domain and tetratricopeptide repeats 2 2 2
MIRT623844 GAN gigaxonin 2 2
MIRT626158 NFYA nuclear transcription factor Y subunit alpha 2 2
MIRT626464 CMKLR1 chemerin chemokine-like receptor 1 2 2
MIRT632087 ALDH1A2 aldehyde dehydrogenase 1 family member A2 2 2
MIRT637243 FAM26E calcium homeostasis modulator family member 5 2 2
MIRT642710 FGFR1OP2 FGFR1 oncogene partner 2 2 2
MIRT643611 KANSL3 KAT8 regulatory NSL complex subunit 3 2 2
MIRT644270 PAFAH1B1 platelet activating factor acetylhydrolase 1b regulatory subunit 1 2 2
MIRT645470 SPIN3 spindlin family member 3 2 2
MIRT649193 DNPEP aspartyl aminopeptidase 2 2
MIRT650776 POP4 POP4 homolog, ribonuclease P/MRP subunit 2 2
MIRT651345 ZC2HC1C zinc finger C2HC-type containing 1C 2 2
MIRT652237 TRAPPC3L trafficking protein particle complex 3 like 2 2
MIRT652587 TIMM8A translocase of inner mitochondrial membrane 8A 2 2
MIRT654591 PURA purine rich element binding protein A 2 2
MIRT654649 PTAFR platelet activating factor receptor 2 2
MIRT656842 KLF7 Kruppel like factor 7 2 2
MIRT657209 IKZF2 IKAROS family zinc finger 2 2 2
MIRT658513 ETV3 ETS variant 3 2 2
MIRT659448 CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 2 2
MIRT668816 CYLD CYLD lysine 63 deubiquitinase 2 2
MIRT669067 CELSR3 cadherin EGF LAG seven-pass G-type receptor 3 2 2
MIRT677711 ELOF1 elongation factor 1 homolog 2 4
MIRT687146 PTPN12 protein tyrosine phosphatase, non-receptor type 12 2 2
MIRT698498 THOC2 THO complex 2 2 2
MIRT707930 PPP1R3D protein phosphatase 1 regulatory subunit 3D 4 2
MIRT708737 FAM71F2 family with sequence similarity 71 member F2 2 2
MIRT710031 POLL DNA polymerase lambda 2 2
MIRT712175 STK4 serine/threonine kinase 4 2 2
MIRT715297 MAPK1 mitogen-activated protein kinase 1 2 2
MIRT716892 AGPAT6 glycerol-3-phosphate acyltransferase 4 2 2
MIRT717378 RBM41 RNA binding motif protein 41 2 2
MIRT718082 CLIC5 chloride intracellular channel 5 2 2
MIRT718721 ANKRD18A ankyrin repeat domain 18A 2 2
MIRT719152 DPYSL5 dihydropyrimidinase like 5 2 2
MIRT719224 CAMK4 calcium/calmodulin dependent protein kinase IV 2 2
MIRT719528 SRCIN1 SRC kinase signaling inhibitor 1 2 2
MIRT719861 KLF2 Kruppel like factor 2 2 2
MIRT720326 CAMK2G calcium/calmodulin dependent protein kinase II gamma 2 2
MIRT721596 SREBF1 sterol regulatory element binding transcription factor 1 2 2
MIRT722020 NEBL nebulette 2 2
MIRT722484 QSOX1 quiescin sulfhydryl oxidase 1 2 2
MIRT722614 TEAD1 TEA domain transcription factor 1 2 2
MIRT723664 RPTN repetin 2 2
MIRT723939 SVOP SV2 related protein 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4301 Cisplatin 5460033 NSC119875 approved sensitive High Hepatocellular Carcinoma cell line (Hep3B, 97L)
hsa-miR-4301 Imatinib 5291 NSC743414 approved resistant High Chronic Myelogenous Leukemia cell line (K562)
hsa-mir-4301 Paclitaxel 36314 NSC125973 approved resistant cell line (BAS)
hsa-mir-4301 Paclitaxel 36314 NSC125973 approved sensitive cell line (W1)
hsa-mir-4301 Doxorubicin 31703 NSC123127 approved sensitive cell line (W1)
hsa-mir-4301 Methotrexate 126941 NSC740 approved sensitive cell line (W1)
hsa-mir-4301 Topotecan 60699 NSC609699 approved sensitive cell line (W1)
hsa-miR-4301 Gefitinib 123631 NSC715055 approved resistant cell line (PC9)
hsa-miR-4301 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

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