miRTarBase - #MIRT528154


—
pre-miRNA Information
pre-miRNA hsa-mir-4749   
Genomic Coordinates chr19: 49854591 - 49854651
Description Homo sapiens miR-4749 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4749-3p
Sequence 42| CGCCCCUCCUGCCCCCACAG |61
Evidence Experimental
Experiments Illumina
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN19730808 2 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs147943327 1 dbSNP
rs148982635 2 dbSNP
rs372882504 3 dbSNP
rs200056596 4 dbSNP
rs570340094 5 dbSNP
rs778438436 11 dbSNP
rs748573000 13 dbSNP
rs770230641 14 dbSNP
rs201103722 16 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol BCL2L1   
Synonyms BCL-XL/S, BCL2L, BCLX, Bcl-X, PPP1R52
Description BCL2 like 1
Transcript NM_138578   
Other Transcripts NM_001191   
Expression
Putative miRNA Targets on BCL2L1
3'UTR of BCL2L1
(miRNA target sites are highlighted)		 
>BCL2L1|NM_138578|3'UTR
   1 CCAGACACTGACCATCCACTCTACCCTCCCACCCCCTTCTCTGCTCCACCACATCCTCCGTCCAGCCGCCATTGCCACCA
  81 GGAGAACCACTACATGCAGCCCATGCCCACCTGCCCATCACAGGGTTGGGCCCAGATCTGGTCCCTTGCAGCTAGTTTTC
 161 TAGAATTTATCACACTTCTGTGAGACCCCCACACCTCAGTTCCCTTGGCCTCAGAATTCACAAAATTTCCACAAAATCTG
 241 TCCAAAGGAGGCTGGCAGGTATGGAAGGGTTTGTGGCTGGGGGCAGGAGGGCCCTACCTGATTGGTGCAACCCTTACCCC
 321 TTAGCCTCCCTGAAAATGTTTTTCTGCCAGGGAGCTTGAAAGTTTTCAGAACCTCTTCCCCAGAAAGGAGACTAGATTGC
 401 CTTTGTTTTGATGTTTGTGGCCTCAGAATTGATCATTTTCCCCCCACTCTCCCCACACTAACCTGGGTTCCCTTTCCTTC
 481 CATCCCTACCCCCTAAGAGCCATTTAGGGGCCACTTTTGACTAGGGATTCAGGCTGCTTGGGATAAAGATGCAAGGACCA
 561 GGACTCCCTCCTCACCTCTGGACTGGCTAGAGTCCTCACTCCCAGTCCAAATGTCCTCCAGAAGCCTCTGGCTAGAGGCC
 641 AGCCCCACCCAGGAGGGAGGGGGCTATAGCTACAGGAAGCACCCCATGCCAAAGCTAGGGTGGCCCTTGCAGTTCAGCAC
 721 CACCCTAGTCCCTTCCCCTCCCTGGCTCCCATGACCATACTGAGGGACCAACTGGGCCCAAGACAGATGCCCCAGAGCTG
 801 TTTATGGCCTCAGCTGCCTCACTTCCTACAAGAGCAGCCTGTGGCATCTTTGCCTTGGGCTGCTCCTCATGGTGGGTTCA
 881 GGGGACTCAGCCCTGAGGTGAAAGGGAGCTATCAGGAACAGCTATGGGAGCCCCAGGGTCTTCCCTACCTCAGGCAGGAA
 961 GGGCAGGAAGGAGAGCCTGCTGCATGGGGTGGGGTAGGGCTGACTAGAAGGGCCAGTCCTGCCTGGCCAGGCAGATCTGT
1041 GCCCCATGCCTGTCCAGCCTGGGCAGCCAGGCTGCCAAGGCCAGAGTGGCCTGGCCAGGAGCTCTTCAGGCCTCCCTCTC
1121 TCTTCTGCTCCACCCTTGGCCTGTCTCATCCCCAGGGGTCCCAGCCACCCCGGGCTCTCTGCTGTACATATTTGAGACTA
1201 GTTTTTATTCCTTGTGAAGATGATATACTATTTTTGTTAAGCGTGTCTGTATTTATGTGTGAGGAGCTGCTGGCTTGCAG
1281 TGCGCGTGCACGTGGAGAGCTGGTGCCCGGAGATTGGACGGCCTGATGCTCCCTCCCCTGCCCTGGTCCAGGGAAGCTGG
1361 CCGAGGGTCCTGGCTCCTGAGGGGCATCTGCCCCTCCCCCAACCCCCACCCCACACTTGTTCCAGCTCTTTGAAATAGTC
1441 TGTGTGAAGGTGAAAGTGCAGTTCAGTAATAAACTGTGTTTACTCAGTGAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' gacACCCCCGUCCUCCCCGc 5'
             |||||||||||||| | 
Target 5' ggcTGGGGGCAGGAGGGCCc 3'
 275 - 294 153.00 -31.20
2 
miRNA  3' gacacCCCCGUCCUCCCCGc 5'
               ||  |  ||||||| 
Target 5' gtcctGGCTCCTGAGGGGCa 3'
 1367 - 1386 143.00 -15.80
3 
miRNA  3' gacacccCCGUCCUCCCCgc 5'
                 || :|||||||  
Target 5' ccacccaGGAGGGAGGGGgc 3'
 645 - 664 133.00 -19.60
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30516422 12 COSMIC
COSN30153975 21 COSMIC
COSN30477605 36 COSMIC
COSN30591120 53 COSMIC
COSN30462607 59 COSMIC
COSN30496869 60 COSMIC
COSN24387724 68 COSMIC
COSN31501279 82 COSMIC
COSN31575007 84 COSMIC
COSN30181223 101 COSMIC
COSN30141227 146 COSMIC
COSN31573807 167 COSMIC
COSN31522982 174 COSMIC
COSN26676840 209 COSMIC
COSN15659943 294 COSMIC
COSN31515077 365 COSMIC
COSN32099867 390 COSMIC
COSN31489757 614 COSMIC
COSN24266726 628 COSMIC
COSN31528278 686 COSMIC
COSN1869589 930 COSMIC
COSN1869588 931 COSMIC
COSN30443842 987 COSMIC
COSN1247448 999 COSMIC
COSN31521406 1108 COSMIC
COSN30162334 1179 COSMIC
COSN22782259 1308 COSMIC
COSN5802493 1388 COSMIC
COSN28816001 1401 COSMIC
COSN14563075 1408 COSMIC
COSN28198296 1411 COSMIC
COSN21016819 1414 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs781506995 6 dbSNP
rs757800093 8 dbSNP
rs751808059 11 dbSNP
rs1244379117 18 dbSNP
rs1246086266 19 dbSNP
rs764588065 19 dbSNP
rs1451150656 20 dbSNP
rs1216554681 25 dbSNP
rs754613701 26 dbSNP
rs753539518 27 dbSNP
rs765845311 35 dbSNP
rs1030657544 36 dbSNP
rs769154919 42 dbSNP
rs760138522 44 dbSNP
rs989916889 46 dbSNP
rs1243372307 48 dbSNP
rs1204774379 50 dbSNP
rs554584920 59 dbSNP
rs967769834 60 dbSNP
rs936677262 62 dbSNP
rs926738457 64 dbSNP
rs1401962362 67 dbSNP
rs980839387 68 dbSNP
rs969871111 79 dbSNP
rs1189056795 85 dbSNP
rs1266419496 98 dbSNP
rs1431216831 106 dbSNP
rs536243459 109 dbSNP
rs1022080146 114 dbSNP
rs1378390732 115 dbSNP
rs1456868565 116 dbSNP
rs1024061730 117 dbSNP
rs992719994 121 dbSNP
rs950656912 123 dbSNP
rs11550475 125 dbSNP
rs1366019003 128 dbSNP
rs1388859223 130 dbSNP
rs1439561988 133 dbSNP
rs1012013351 136 dbSNP
rs565690849 141 dbSNP
rs10861 152 dbSNP
rs1026219616 153 dbSNP
rs1227351857 169 dbSNP
rs1469106584 175 dbSNP
rs1035270230 180 dbSNP
rs1265066225 187 dbSNP
rs1219594547 188 dbSNP
rs994947146 189 dbSNP
rs1211389391 191 dbSNP
rs963075237 194 dbSNP
rs1003429993 202 dbSNP
rs1284972258 203 dbSNP
rs1180214408 207 dbSNP
rs886391008 208 dbSNP
rs1007283064 217 dbSNP
rs890642399 245 dbSNP
rs1239403000 248 dbSNP
rs1211982630 251 dbSNP
rs1459857115 254 dbSNP
rs1294518867 257 dbSNP
rs1370266387 264 dbSNP
rs1051910841 282 dbSNP
rs1047719179 288 dbSNP
rs1305403228 290 dbSNP
rs1441336995 293 dbSNP
rs1351870582 294 dbSNP
rs1009721157 298 dbSNP
rs1311981294 300 dbSNP
rs1366585869 302 dbSNP
rs1246818848 305 dbSNP
rs1291463957 314 dbSNP
rs770055952 320 dbSNP
rs34865640 331 dbSNP
rs1203367777 339 dbSNP
rs1254213489 342 dbSNP
rs1481030032 344 dbSNP
rs553661086 346 dbSNP
rs538525918 355 dbSNP
rs899244011 357 dbSNP
rs1345286656 360 dbSNP
rs1039065909 373 dbSNP
rs1390006220 378 dbSNP
rs1428216419 383 dbSNP
rs943451680 393 dbSNP
rs936669303 394 dbSNP
rs912030586 421 dbSNP
rs1301760882 425 dbSNP
rs1175975823 438 dbSNP
rs1230017270 439 dbSNP
rs1315641317 440 dbSNP
rs1341251098 441 dbSNP
rs1434147554 442 dbSNP
rs926610351 445 dbSNP
rs1308337516 446 dbSNP
rs1209595844 452 dbSNP
rs1267028357 456 dbSNP
rs1189703298 467 dbSNP
rs571443689 471 dbSNP
rs1045137100 472 dbSNP
rs988079245 477 dbSNP
rs1247914621 482 dbSNP
rs1264078411 484 dbSNP
rs745601479 485 dbSNP
rs924878889 492 dbSNP
rs549690378 493 dbSNP
rs1449547207 495 dbSNP
rs531471504 499 dbSNP
rs1351481436 502 dbSNP
rs1337370233 510 dbSNP
rs950573836 520 dbSNP
rs977738014 526 dbSNP
rs1364404340 533 dbSNP
rs967674861 537 dbSNP
rs1021986730 549 dbSNP
rs990531438 570 dbSNP
rs1282410414 574 dbSNP
rs959393524 575 dbSNP
rs919209235 576 dbSNP
rs1362322222 581 dbSNP
rs1034853217 586 dbSNP
rs567358983 588 dbSNP
rs1003826513 590 dbSNP
rs1314061712 599 dbSNP
rs886341110 604 dbSNP
rs112085564 610 dbSNP
rs527283085 611 dbSNP
rs994726961 617 dbSNP
rs1017242553 619 dbSNP
rs1190998136 624 dbSNP
rs756689819 628 dbSNP
rs1477903211 631 dbSNP
rs1190313769 639 dbSNP
rs1422598302 648 dbSNP
rs954468617 650 dbSNP
rs1362224634 656 dbSNP
rs1297091899 657 dbSNP
rs1455587429 659 dbSNP
rs116990630 660 dbSNP
rs1009778373 667 dbSNP
rs1376694397 674 dbSNP
rs1039018055 676 dbSNP
rs770813221 678 dbSNP
rs747000648 680 dbSNP
rs1377474392 686 dbSNP
rs905208400 703 dbSNP
rs1045066584 712 dbSNP
rs541725032 717 dbSNP
rs1051918296 718 dbSNP
rs934851519 724 dbSNP
rs1248781577 731 dbSNP
rs924784207 736 dbSNP
rs777327056 738 dbSNP
rs1410656541 743 dbSNP
rs558611326 746 dbSNP
rs1160265045 751 dbSNP
rs914879726 760 dbSNP
rs990927727 766 dbSNP
rs532665035 768 dbSNP
rs1367131681 769 dbSNP
rs1405843973 771 dbSNP
rs560997987 771 dbSNP
rs1348751835 777 dbSNP
rs1230279923 792 dbSNP
rs1280165152 806 dbSNP
rs1356304108 814 dbSNP
rs757916272 816 dbSNP
rs927726767 822 dbSNP
rs116239579 825 dbSNP
rs950577686 829 dbSNP
rs1026123997 832 dbSNP
rs1482879175 835 dbSNP
rs1222853389 837 dbSNP
rs1250570354 840 dbSNP
rs994679279 844 dbSNP
rs755868976 845 dbSNP
rs752260890 855 dbSNP
rs778372909 856 dbSNP
rs963297847 859 dbSNP
rs1254099326 865 dbSNP
rs1161332555 869 dbSNP
rs1386934123 872 dbSNP
rs543647087 876 dbSNP
rs1007995653 877 dbSNP
rs184626287 884 dbSNP
rs1329633220 886 dbSNP
rs1339891380 893 dbSNP
rs1052251835 897 dbSNP
rs1286459966 904 dbSNP
rs957105328 908 dbSNP
rs1216335005 909 dbSNP
rs750779574 911 dbSNP
rs3208680 914 dbSNP
rs998965064 919 dbSNP
rs1272868134 923 dbSNP
rs1312939254 924 dbSNP
rs1339671718 930 dbSNP
rs903310810 931 dbSNP
rs1197113435 932 dbSNP
rs3208681 933 dbSNP
rs3208682 934 dbSNP
rs3208683 938 dbSNP
rs1043257240 943 dbSNP
rs3208684 947 dbSNP
rs554647826 962 dbSNP
rs947612698 966 dbSNP
rs1185381532 967 dbSNP
rs1244872626 975 dbSNP
rs916206720 979 dbSNP
rs1402079072 982 dbSNP
rs1001422125 984 dbSNP
rs768032844 988 dbSNP
rs1463871491 991 dbSNP
rs542672064 993 dbSNP
rs1168703120 1011 dbSNP
rs1401668119 1014 dbSNP
rs192023484 1017 dbSNP
rs1339323713 1023 dbSNP
rs1384208295 1024 dbSNP
rs937704469 1028 dbSNP
rs1013582422 1030 dbSNP
rs553855036 1039 dbSNP
rs1328507787 1042 dbSNP
rs1476932291 1043 dbSNP
rs1251497143 1052 dbSNP
rs1420185462 1053 dbSNP
rs1343735626 1056 dbSNP
rs1188329969 1057 dbSNP
rs927665237 1058 dbSNP
rs758028362 1062 dbSNP
rs1198256055 1064 dbSNP
rs1264420896 1067 dbSNP
rs1187793841 1071 dbSNP
rs745345322 1073 dbSNP
rs1430075342 1074 dbSNP
rs1194212485 1076 dbSNP
rs982246124 1076 dbSNP
rs1477133801 1077 dbSNP
rs1178715471 1078 dbSNP
rs1406832982 1087 dbSNP
rs950479047 1092 dbSNP
rs1457189941 1093 dbSNP
rs919083667 1102 dbSNP
rs1387647930 1107 dbSNP
rs1383104954 1114 dbSNP
rs1047144314 1115 dbSNP
rs930050069 1116 dbSNP
rs1197438126 1120 dbSNP
rs1221237965 1125 dbSNP
rs1284666450 1127 dbSNP
rs1323614461 1128 dbSNP
rs1458073735 1130 dbSNP
rs537018288 1134 dbSNP
rs963245815 1135 dbSNP
rs1196434090 1136 dbSNP
rs1266357342 1145 dbSNP
rs1431661789 1148 dbSNP
rs1336482604 1151 dbSNP
rs1037564035 1155 dbSNP
rs188120954 1159 dbSNP
rs1472302496 1161 dbSNP
rs1007487936 1171 dbSNP
rs1338141277 1172 dbSNP
rs1454727310 1184 dbSNP
rs1311245855 1187 dbSNP
rs1439613768 1188 dbSNP
rs1393578586 1199 dbSNP
rs1378129250 1210 dbSNP
rs368749245 1217 dbSNP
rs910510174 1220 dbSNP
rs954847298 1225 dbSNP
rs1227216518 1226 dbSNP
rs1304169504 1229 dbSNP
rs1331082592 1240 dbSNP
rs1318688259 1242 dbSNP
rs1030332085 1243 dbSNP
rs1239596198 1246 dbSNP
rs1464323762 1249 dbSNP
rs752115367 1251 dbSNP
rs1163963370 1256 dbSNP
rs1457491030 1267 dbSNP
rs1269843260 1273 dbSNP
rs1482823858 1274 dbSNP
rs1180148264 1277 dbSNP
rs1252678512 1278 dbSNP
rs867739143 1281 dbSNP
rs922902117 1283 dbSNP
rs903304395 1284 dbSNP
rs988311854 1285 dbSNP
rs956504890 1286 dbSNP
rs184805060 1291 dbSNP
rs554667741 1292 dbSNP
rs1295947703 1305 dbSNP
rs1011777629 1308 dbSNP
rs979657125 1314 dbSNP
rs537638536 1319 dbSNP
rs1208829342 1322 dbSNP
rs759097020 1322 dbSNP
rs1056422275 1328 dbSNP
rs938965741 1329 dbSNP
rs1292181067 1332 dbSNP
rs1341730541 1335 dbSNP
rs1202627574 1338 dbSNP
rs906153196 1349 dbSNP
rs1261912657 1357 dbSNP
rs1046098430 1362 dbSNP
rs865787655 1363 dbSNP
rs1241808467 1372 dbSNP
rs1446917838 1373 dbSNP
rs929055673 1379 dbSNP
rs567420266 1388 dbSNP
rs1389864939 1392 dbSNP
rs1309042682 1393 dbSNP
rs753679722 1395 dbSNP
rs1325159273 1404 dbSNP
rs1355842491 1408 dbSNP
rs908701953 1408 dbSNP
rs1462023611 1410 dbSNP
rs549105385 1416 dbSNP
rs973197792 1422 dbSNP
rs1380534907 1423 dbSNP
rs1454446190 1424 dbSNP
rs527346866 1450 dbSNP
rs1364181676 1452 dbSNP
rs898608725 1462 dbSNP
rs1324497112 1464 dbSNP
rs1386366488 1466 dbSNP
rs910403008 1467 dbSNP
rs986411458 1474 dbSNP
rs138866312 1475 dbSNP
rs1030742158 1487 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions hESCs (WA-09)
Disease 598.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in SRR359787. RNA binding protein: AGO2. Condition:4-thiouridine ...

- Lipchina I; Elkabetz Y; Hafner M; Sheridan et al., 2011, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' gacacccccguCCUCCCCGc 5'
                     ||| |||: 
Target 5' -----------GGAAGGGUu 3'
 		1 - 9
Article - Lipchina I; Elkabetz Y; Hafner M; Sheridan et al.
- Genes & development, 2011
MicroRNAs are important regulators in many cellular processes, including stem cell self-renewal. Recent studies demonstrated their function as pluripotency factors with the capacity for somatic cell reprogramming. However, their role in human embryonic stem (ES) cells (hESCs) remains poorly understood, partially due to the lack of genome-wide strategies to identify their targets. Here, we performed comprehensive microRNA profiling in hESCs and in purified neural and mesenchymal derivatives. Using a combination of AGO cross-linking and microRNA perturbation experiments, together with computational prediction, we identified the targets of the miR-302/367 cluster, the most abundant microRNAs in hESCs. Functional studies identified novel roles of miR-302/367 in maintaining pluripotency and regulating hESC differentiation. We show that in addition to its role in TGF-beta signaling, miR-302/367 promotes bone morphogenetic protein (BMP) signaling by targeting BMP inhibitors TOB2, DAZAP2, and SLAIN1. This study broadens our understanding of microRNA function in hESCs and is a valuable resource for future studies in this area.
LinkOut: [PMID: 22012620]
CLIP-seq Support 1 for dataset SRR359787
Method / RBP PAR-CLIP / AGO2
Cell line / Condition hESCs (WA-09) / 4-thiouridine, RNase T1
Location of target site ENST00000376062.2 | 3UTR | GGAAGGGUUUGUGGCUGGGGG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22012620 / SRX103431
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
63 hsa-miR-4749-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT082256 MED29 mediator complex subunit 29 2 4
MIRT112161 OTUD3 OTU deubiquitinase 3 2 2
MIRT150036 MIDN midnolin 2 2
MIRT246308 HIST2H2AA3 histone cluster 2 H2A family member a3 2 4
MIRT246320 HIST2H2AA4 histone cluster 2 H2A family member a4 2 4
MIRT248254 SP1 Sp1 transcription factor 2 2
MIRT257944 GIGYF1 GRB10 interacting GYF protein 1 2 2
MIRT466973 STARD7 StAR related lipid transfer domain containing 7 2 4
MIRT492322 SETD1B SET domain containing 1B 2 2
MIRT496204 EFCAB1 EF-hand calcium binding domain 1 2 2
MIRT497568 CCR6 C-C motif chemokine receptor 6 2 2
MIRT502990 CCDC71L coiled-coil domain containing 71 like 2 8
MIRT508300 SIX5 SIX homeobox 5 2 4
MIRT522472 ZAK mitogen-activated protein kinase kinase kinase 20 2 2
MIRT525825 VIMP selenoprotein S 2 4
MIRT528154 BCL2L1 BCL2 like 1 2 2
MIRT532606 SPTLC2 serine palmitoyltransferase long chain base subunit 2 2 2
MIRT551302 RPRM reprimo, TP53 dependent G2 arrest mediator homolog 2 2
MIRT568777 FAM53C family with sequence similarity 53 member C 2 6
MIRT570896 METTL21A methyltransferase like 21A 2 2
MIRT570963 TMBIM4 transmembrane BAX inhibitor motif containing 4 2 2
MIRT571167 ZNF85 zinc finger protein 85 2 2
MIRT576751 Tmem127 transmembrane protein 127 2 2
MIRT609854 DAZAP2 DAZ associated protein 2 2 2
MIRT627101 PDRG1 p53 and DNA damage regulated 1 2 2
MIRT637060 PRKAG1 protein kinase AMP-activated non-catalytic subunit gamma 1 2 2
MIRT639423 PKP1 plakophilin 1 2 2
MIRT643208 TYW3 tRNA-yW synthesizing protein 3 homolog 2 4
MIRT646251 PRSS38 protease, serine 38 2 2
MIRT647145 CYP27C1 cytochrome P450 family 27 subfamily C member 1 2 2
MIRT647429 ZKSCAN2 zinc finger with KRAB and SCAN domains 2 2 2
MIRT650666 GAPDHP44 glyceraldehyde 3 phosphate dehydrogenase pseudogene 44 2 2
MIRT651816 USP49 ubiquitin specific peptidase 49 2 2
MIRT657376 HMGA1 high mobility group AT-hook 1 2 2
MIRT658105 FOXK1 forkhead box K1 2 2
MIRT658161 FCHSD1 FCH and double SH3 domains 1 2 2
MIRT662754 LRRC3C leucine rich repeat containing 3C 2 2
MIRT667209 NIPAL1 NIPA like domain containing 1 2 2
MIRT687003 RPL35 ribosomal protein L35 2 2
MIRT707057 NACC2 NACC family member 2 2 2
MIRT709048 MRO maestro 2 2
MIRT709054 MGAT5B mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B 2 2
MIRT709446 VWA2 von Willebrand factor A domain containing 2 2 2
MIRT709847 SNX12 sorting nexin 12 2 2
MIRT710790 IFNLR1 interferon lambda receptor 1 2 2
MIRT711696 GMPR guanosine monophosphate reductase 2 2
MIRT712462 KCNC3 potassium voltage-gated channel subfamily C member 3 2 2
MIRT713884 MOB3A MOB kinase activator 3A 2 2
MIRT715329 NTN1 netrin 1 2 2
MIRT715927 CHD4 chromodomain helicase DNA binding protein 4 2 2
MIRT716533 ATF5 activating transcription factor 5 2 2
MIRT716937 CACNB1 calcium voltage-gated channel auxiliary subunit beta 1 2 2
MIRT717007 MFSD6 major facilitator superfamily domain containing 6 2 2
MIRT719139 DPYSL5 dihydropyrimidinase like 5 2 2
MIRT720853 MEF2D myocyte enhancer factor 2D 2 2
MIRT721484 LTB4R2 leukotriene B4 receptor 2 2 2
MIRT721517 DKK3 dickkopf WNT signaling pathway inhibitor 3 2 2
MIRT722895 LRRC20 leucine rich repeat containing 20 2 2
MIRT723066 GGA1 golgi associated, gamma adaptin ear containing, ARF binding protein 1 2 2
MIRT723086 INSIG1 insulin induced gene 1 2 2
MIRT723353 ASCL2 achaete-scute family bHLH transcription factor 2 2 2
MIRT723483 MINOS1 mitochondrial inner membrane organizing system 1 2 2
MIRT724576 NOTCH2 notch 2 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4749 Fluorouracil 3385 NSC19893 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-mir-4749 Gemcitabine 60750 NSC613327 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-mir-4749 Paclitaxel 36314 NSC125973 approved resistant cell line (W1)
hsa-miR-4749-3p Cisplatin 5460033 NSC119875 approved resistant High Hypopharyngeal Cancer cell line (FaDu)
hsa-miR-4749-3p Tamoxifen+Fulvestrant sensitive cell line (LCC9)
hsa-miR-4749-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-miR-4749-3p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)
hsa-miR-4749-3p Cisplatin 5460033 NSC119875 approved resistant cell line (OVSAHO)
hsa-miR-4749-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (TOV-112D)

Error report submission