pre-miRNA Information
pre-miRNA hsa-mir-497   
Genomic Coordinates chr17: 7017911 - 7018022
Synonyms MIRN497, hsa-mir-497, MIR497
Description Homo sapiens miR-497 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-497-3p
Sequence 64| CAAACCACACUGUGGUGUUAGA |85
Evidence Experimental
Experiments Cloned
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 3 17 - 7017957 29233923 MiREDiBase
A-to-I 4 17 - 7017956 29233923 MiREDiBase
A-to-I 20 17 - 7017940 24964909, 25521855, 27229138, 29165639, 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1413601274 5 dbSNP
rs1028648384 6 dbSNP
rs1479092960 9 dbSNP
rs1261056598 10 dbSNP
rs997278260 11 dbSNP
rs1324708562 13 dbSNP
rs755634302 21 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol PLEKHM2   
Synonyms SKIP
Description pleckstrin homology and RUN domain containing M2
Transcript NM_015164   
Expression
Putative miRNA Targets on PLEKHM2
3'UTR of PLEKHM2
(miRNA target sites are highlighted)
>PLEKHM2|NM_015164|3'UTR
   1 GGCAGAGCTGGTTGGCGTCCCTGGTGGGCAGGAAAGGAAGGCACGCCAGCCGGCAGGCACACTGTCACGGCTGTTGTCAT
  81 GCTGTCGGGAGCCTACAGTCCACCCCTGCCCTGGGCGGCAGAACCACCGAGTGTGGCTTAAGACAGGGTCCCTCCACTCC
 161 AGGGATCCAGATCAGGTGCCCGGCACCCCTGGGCATCCTGCCCGACAGGTAGCGAATGGAGGTCGCTGGGGGCAGAGGGT
 241 CCGAGCCCTGTGGGCTCTGCGGATGCACGCCCTCCTCCCGGGCCTCCGCCTCAGTCTGCAGAATTTCTGCCGAGTGGCAC
 321 CGAGAACACCATCCATCTAAGGACGAACAAAAGAACCAGGAGGGCGGGACCCCCCTCTTCCTCTCCTGGGTTGGGGGCTG
 401 GGGCCCTGAGTGCCCAGCCATCCTTGTTCGTGTTTGAACACTCTCCTGGCCACGTGGGGAAGCGGGAACACGGGGTGTCT
 481 GCGCATGTTTCCTCCTCCTAGCTCCATCACTGCGCACACAGCTGCCTGCCTCGCCAGATGCAGGGGGGCGGGCAGCCCTC
 561 CCTGGCTGCCAGGAGGCTCTGCATGCCCACAGTCCTGCCCTGCCTGTCCCCTCAACCCGGCAGTGCCTGTAGCACCGAGG
 641 AGCAAAGGGGGTGGATGGGGGGCTTGGAGAAGGGCGGAGCCCACCAGCCTGGCATCCATGTTGACATCTTCTGACTGTCC
 721 CCTGCTTGGCTGGAGCCAGGCCCTTCCCTAGAGTTTCGTCAAGAGCCTCCTGGGGAAGGGGTCAGGTGGTTTGGGTTTTG
 801 TTTTTTAAAATAAAATAGACATGTTATATTGCCAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' agauugugguGUCACACCAAAc 5'
                    ||| ||||||| 
Target 5' gggaaggggtCAG-GTGGTTTg 3'
773 - 793 147.00 -14.70
2
miRNA  3' agaUUGUGGUG--UCACACCAAAc 5'
             |: |||||  ||||||| || 
Target 5' ggcAGAACCACCGAGTGTGGCTTa 3'
117 - 140 141.00 -16.56
3
miRNA  3' agAUUGUGG-----UGU----CACACCAAac 5'
            ||:||||     :||    | |||| |  
Target 5' tgTAGCACCGAGGAGCAAAGGGGGTGGATgg 3'
628 - 658 102.00 -17.10
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
1175687 250 ClinVar
COSN30451036 21 COSMIC
COSN26561315 28 COSMIC
COSN30527113 47 COSMIC
COSN30498618 52 COSMIC
COSN19771127 54 COSMIC
COSN31550012 116 COSMIC
COSN31960180 183 COSMIC
COSN30344106 270 COSMIC
COSN18723368 483 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs567449777 4 dbSNP
rs1329272068 8 dbSNP
rs759289109 13 dbSNP
rs986180418 15 dbSNP
rs1263464589 16 dbSNP
rs751706088 17 dbSNP
rs373277994 18 dbSNP
rs781591637 27 dbSNP
rs750460965 29 dbSNP
rs756275044 36 dbSNP
rs780125685 41 dbSNP
rs377689243 42 dbSNP
rs1202235828 43 dbSNP
rs768306027 45 dbSNP
rs1042752150 46 dbSNP
rs1157469002 47 dbSNP
rs1347153801 50 dbSNP
rs1454563892 51 dbSNP
rs371434584 52 dbSNP
rs934828955 53 dbSNP
rs1392790191 54 dbSNP
rs760832371 58 dbSNP
rs902881532 69 dbSNP
rs77963885 70 dbSNP
rs1268884618 71 dbSNP
rs576674477 75 dbSNP
rs896045807 77 dbSNP
rs949023126 78 dbSNP
rs779221714 86 dbSNP
rs1033198937 88 dbSNP
rs1305770489 93 dbSNP
rs1225082599 94 dbSNP
rs1045061319 100 dbSNP
rs888421515 103 dbSNP
rs1192227193 107 dbSNP
rs1371226967 109 dbSNP
rs1476374621 116 dbSNP
rs1168646730 118 dbSNP
rs1334716885 122 dbSNP
rs1422221012 123 dbSNP
rs1244872414 128 dbSNP
rs963815002 129 dbSNP
rs1015684285 130 dbSNP
rs1285377560 139 dbSNP
rs1359091616 141 dbSNP
rs144541067 144 dbSNP
rs897277307 145 dbSNP
rs1316736971 147 dbSNP
rs559215130 155 dbSNP
rs754045311 156 dbSNP
rs1436541068 171 dbSNP
rs1030187988 172 dbSNP
rs1248276561 178 dbSNP
rs368388509 179 dbSNP
rs1266205380 182 dbSNP
rs954959099 182 dbSNP
rs150699153 183 dbSNP
rs908133971 185 dbSNP
rs1204296252 186 dbSNP
rs1259457083 188 dbSNP
rs1207623545 199 dbSNP
rs541053509 202 dbSNP
rs1242472670 205 dbSNP
rs1442189939 214 dbSNP
rs139674413 215 dbSNP
rs1368654283 222 dbSNP
rs920690898 225 dbSNP
rs1317307520 226 dbSNP
rs1017480747 229 dbSNP
rs755187659 230 dbSNP
rs978438165 232 dbSNP
rs924359150 233 dbSNP
rs1454606797 234 dbSNP
rs1313580255 238 dbSNP
rs1335376165 243 dbSNP
rs1237226973 244 dbSNP
rs560946809 248 dbSNP
rs7553242 250 dbSNP
rs1262389327 251 dbSNP
rs1162811308 261 dbSNP
rs993387784 262 dbSNP
rs917054777 266 dbSNP
rs543635658 269 dbSNP
rs181429747 270 dbSNP
rs1179146971 278 dbSNP
rs948914735 280 dbSNP
rs753016959 281 dbSNP
rs903081657 288 dbSNP
rs186914798 289 dbSNP
rs1471270509 291 dbSNP
rs1303486910 295 dbSNP
rs1395944050 308 dbSNP
rs1389748278 310 dbSNP
rs1054097360 312 dbSNP
rs899597010 313 dbSNP
rs996511649 322 dbSNP
rs1029361788 323 dbSNP
rs1479994567 325 dbSNP
rs1314940456 330 dbSNP
rs954915975 336 dbSNP
rs1193593469 337 dbSNP
rs1253471913 345 dbSNP
rs1343390762 346 dbSNP
rs1199121992 349 dbSNP
rs558896831 366 dbSNP
rs778252076 367 dbSNP
rs1007805975 368 dbSNP
rs1373033590 370 dbSNP
rs1017474508 373 dbSNP
rs1015623453 375 dbSNP
rs1339000122 378 dbSNP
rs1302306879 386 dbSNP
rs1343340069 398 dbSNP
rs968642160 400 dbSNP
rs962292362 404 dbSNP
rs1201206226 405 dbSNP
rs1258392417 408 dbSNP
rs973830387 418 dbSNP
rs920569282 427 dbSNP
rs559620403 430 dbSNP
rs576980081 431 dbSNP
rs917334748 444 dbSNP
rs1266333798 447 dbSNP
rs949887519 454 dbSNP
rs1041560102 455 dbSNP
rs1261606138 461 dbSNP
rs10927843 464 dbSNP
rs1168073274 465 dbSNP
rs779449385 467 dbSNP
rs1390942952 472 dbSNP
rs544399126 472 dbSNP
rs899462528 473 dbSNP
rs41270295 479 dbSNP
rs1438294388 482 dbSNP
rs536395207 483 dbSNP
rs1468822469 484 dbSNP
rs1380515503 486 dbSNP
rs980710484 490 dbSNP
rs1336731857 498 dbSNP
rs890865136 499 dbSNP
rs116089142 507 dbSNP
rs1437830959 510 dbSNP
rs774137832 514 dbSNP
rs1289091210 515 dbSNP
rs1015070154 517 dbSNP
rs747942456 519 dbSNP
rs79668581 529 dbSNP
rs1037305320 533 dbSNP
rs1485177802 535 dbSNP
rs1190991090 543 dbSNP
rs1249208234 545 dbSNP
rs918560685 549 dbSNP
rs375228006 550 dbSNP
rs1416185521 551 dbSNP
rs1406219569 553 dbSNP
rs1165196410 554 dbSNP
rs113565441 560 dbSNP
rs995066748 562 dbSNP
rs1321580728 566 dbSNP
rs1455446834 578 dbSNP
rs1322395125 581 dbSNP
rs1028314499 586 dbSNP
rs1203114899 587 dbSNP
rs958733326 588 dbSNP
rs1451241112 592 dbSNP
rs7748 607 dbSNP
rs1024423761 610 dbSNP
rs971440568 619 dbSNP
rs1283128595 620 dbSNP
rs1260824842 623 dbSNP
rs558959495 628 dbSNP
rs1433531789 632 dbSNP
rs977268702 637 dbSNP
rs537362875 638 dbSNP
rs1426767041 639 dbSNP
rs1269278729 647 dbSNP
rs763823699 649 dbSNP
rs990125040 651 dbSNP
rs921163056 652 dbSNP
rs932350413 655 dbSNP
rs1050692419 658 dbSNP
rs1038874394 661 dbSNP
rs1176763937 663 dbSNP
rs773250512 667 dbSNP
rs1390145705 668 dbSNP
rs566409536 670 dbSNP
rs1036947215 677 dbSNP
rs1389261981 681 dbSNP
rs898029293 685 dbSNP
rs995411155 689 dbSNP
rs148967579 695 dbSNP
rs1303770263 699 dbSNP
rs1278546465 700 dbSNP
rs1230584817 701 dbSNP
rs1289420292 707 dbSNP
rs1343885485 716 dbSNP
rs955699491 718 dbSNP
rs576310999 720 dbSNP
rs1281353341 723 dbSNP
rs1443015751 728 dbSNP
rs1024049434 739 dbSNP
rs1231355052 747 dbSNP
rs1484188068 754 dbSNP
rs970240702 758 dbSNP
rs554649631 759 dbSNP
rs1322170218 765 dbSNP
rs541887272 767 dbSNP
rs971471610 769 dbSNP
rs1427211951 774 dbSNP
rs760712578 776 dbSNP
rs980248108 777 dbSNP
rs1327654316 782 dbSNP
rs751519266 786 dbSNP
rs1368289670 793 dbSNP
rs868753898 799 dbSNP
rs910028149 808 dbSNP
rs1309011497 815 dbSNP
rs977497510 817 dbSNP
rs972944282 821 dbSNP
rs918835342 822 dbSNP
rs1346364075 823 dbSNP
rs1032162860 824 dbSNP
rs1271042893 833 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions hESCs (WA-09)
Disease 23207.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in SRR359787. RNA binding protein: AGO2. Condition:4-thiouridine ...

- Lipchina I; Elkabetz Y; Hafner M; Sheridan et al., 2011, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' agauugugguGUCACACCAAAc 5'
                    ||| ||||||| 
Target 5' ---------uCAG-GUGGUUUg 3'
1 - 12
Article - Lipchina I; Elkabetz Y; Hafner M; Sheridan et al.
- Genes & development, 2011
MicroRNAs are important regulators in many cellular processes, including stem cell self-renewal. Recent studies demonstrated their function as pluripotency factors with the capacity for somatic cell reprogramming. However, their role in human embryonic stem (ES) cells (hESCs) remains poorly understood, partially due to the lack of genome-wide strategies to identify their targets. Here, we performed comprehensive microRNA profiling in hESCs and in purified neural and mesenchymal derivatives. Using a combination of AGO cross-linking and microRNA perturbation experiments, together with computational prediction, we identified the targets of the miR-302/367 cluster, the most abundant microRNAs in hESCs. Functional studies identified novel roles of miR-302/367 in maintaining pluripotency and regulating hESC differentiation. We show that in addition to its role in TGF-beta signaling, miR-302/367 promotes bone morphogenetic protein (BMP) signaling by targeting BMP inhibitors TOB2, DAZAP2, and SLAIN1. This study broadens our understanding of microRNA function in hESCs and is a valuable resource for future studies in this area.
LinkOut: [PMID: 22012620]
CLIP-seq Support 1 for dataset SRR359787
Method / RBP PAR-CLIP / AGO2
Cell line / Condition hESCs (WA-09) / 4-thiouridine, RNase T1
Location of target site ENST00000375799.3 | 3UTR | UCAGGUGGUUUGGGUUUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22012620 / SRX103431
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE42095 Differentiated embryonic stem cells 0.594 1.4e-3 0.475 1.1e-2 23 Click to see details
GSE28260 Renal cortex and medulla 0.673 5.9e-3 0.537 2.9e-2 13 Click to see details
GSE38974 Chronic obstructive pulmonary disease 0.456 1.1e-2 0.620 4.7e-4 25 Click to see details
GSE28544 Breast cancer 0.447 1.4e-2 0.594 1.1e-3 24 Click to see details
GSE19350 CNS germ cell tumors 0.603 1.9e-2 0.503 4.8e-2 12 Click to see details
GSE38226 Liver fibrosis -0.439 2.3e-2 -0.412 3.2e-2 21 Click to see details
GSE26953 Aortic valvular endothelial cells -0.338 5.3e-2 -0.042 4.2e-1 24 Click to see details
GSE32688 Pancreatic cancer -0.197 1.4e-1 -0.150 2.1e-1 32 Click to see details
GSE21687 Ependynoma primary tumors -0.119 1.7e-1 -0.091 2.4e-1 64 Click to see details
GSE17498 Multiple myeloma -0.067 3.4e-1 -0.074 3.2e-1 40 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.014 4.8e-1 0.220 1.8e-1 20 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.014 4.8e-1 0.220 1.8e-1 20 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.014 4.8e-1 0.220 1.8e-1 20 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
ESCA 0.708 0.01 0.491 0.07 10 Click to see details
BRCA -0.32 0.02 -0.327 0.02 42 Click to see details
THCA -0.246 0.05 -0.201 0.09 45 Click to see details
CHOL -0.605 0.1 -0.600 0.1 6 Click to see details
HNSC -0.277 0.13 -0.286 0.12 18 Click to see details
KIRC 0.16 0.15 0.202 0.1 43 Click to see details
LUSC -0.183 0.17 -0.228 0.11 30 Click to see details
PAAD -0.593 0.2 -0.800 0.1 4 Click to see details
KICH 0.135 0.32 0.104 0.36 15 Click to see details
KIRP 0.098 0.34 0.082 0.36 21 Click to see details
STAD -0.08 0.37 0.055 0.41 21 Click to see details
BLCA 0.198 0.4 -0.200 0.4 4 Click to see details
UCEC -0.044 0.44 0.065 0.41 16 Click to see details
LUAD -0.08 0.46 -0.600 0.2 4 Click to see details
LIHC 0.005 0.49 0.238 0.1 30 Click to see details
PRAD 0.001 0.5 -0.039 0.4 46 Click to see details
PRAD 0.001 0.5 -0.039 0.4 46 Click to see details
PRAD 0.001 0.5 -0.039 0.4 46 Click to see details
PRAD 0.001 0.5 -0.039 0.4 46 Click to see details
95 hsa-miR-497-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT092955 CYP2U1 cytochrome P450 family 2 subfamily U member 1 2 4
MIRT124568 PRRC2B proline rich coiled-coil 2B 2 2
MIRT125196 EIF1AX eukaryotic translation initiation factor 1A, X-linked 2 4
MIRT147296 KPNA2 karyopherin subunit alpha 2 2 8
MIRT163999 KIAA1109 KIAA1109 2 4
MIRT252495 NWD1 NACHT and WD repeat domain containing 1 2 2
MIRT357969 GRPEL2 GrpE like 2, mitochondrial 2 2
MIRT443007 TRIOBP TRIO and F-actin binding protein 2 2
MIRT443524 NETO1 neuropilin and tolloid like 1 2 2
MIRT443573 EVX2 even-skipped homeobox 2 2 2
MIRT443656 BACH1 BTB domain and CNC homolog 1 2 2
MIRT460670 KRT10 keratin 10 2 8
MIRT464761 UBE2N ubiquitin conjugating enzyme E2 N 2 2
MIRT465032 LINC00598 long intergenic non-protein coding RNA 598 2 2
MIRT465040 TTC39C tetratricopeptide repeat domain 39C 2 2
MIRT468667 SEC62 SEC62 homolog, preprotein translocation factor 2 2
MIRT473694 MAPK8 mitogen-activated protein kinase 8 2 4
MIRT477618 EFNA3 ephrin A3 2 2
MIRT480506 C11orf57 chromosome 11 open reading frame 57 2 2
MIRT480592 BUB3 BUB3, mitotic checkpoint protein 2 2
MIRT486915 ZNF398 zinc finger protein 398 2 6
MIRT487770 ANKEF1 ankyrin repeat and EF-hand domain containing 1 2 16
MIRT493265 MDFIC MyoD family inhibitor domain containing 2 2
MIRT495271 SLC1A2 solute carrier family 1 member 2 2 4
MIRT495309 CHST12 carbohydrate sulfotransferase 12 2 2
MIRT496681 DPP6 dipeptidyl peptidase like 6 2 4
MIRT496891 FOXP1 forkhead box P1 2 2
MIRT497330 IRF4 interferon regulatory factor 4 2 2
MIRT498272 KIAA1644 KIAA1644 2 2
MIRT498634 CHD4 chromodomain helicase DNA binding protein 4 2 10
MIRT500581 USP53 ubiquitin specific peptidase 53 2 2
MIRT500751 TMPPE transmembrane protein with metallophosphoesterase domain 2 6
MIRT509668 ZNF354B zinc finger protein 354B 2 10
MIRT510919 PSMA2 proteasome subunit alpha 2 2 4
MIRT519118 CEP76 centrosomal protein 76 2 2
MIRT526193 ABCG2 ATP binding cassette subfamily G member 2 (Junior blood group) 2 2
MIRT526746 HLA-DOB major histocompatibility complex, class II, DO beta 2 2
MIRT527270 FBLN2 fibulin 2 2 2
MIRT528198 PLEKHM2 pleckstrin homology and RUN domain containing M2 2 2
MIRT528330 TBC1D22B TBC1 domain family member 22B 2 2
MIRT530346 GABRB3 gamma-aminobutyric acid type A receptor beta3 subunit 2 2
MIRT533627 TMX3 thioredoxin related transmembrane protein 3 2 2
MIRT533738 TMEM200C transmembrane protein 200C 2 2
MIRT533779 TMEM133 transmembrane protein 133 2 2
MIRT534317 SKIDA1 SKI/DACH domain containing 1 2 2
MIRT538438 COG5 component of oligomeric golgi complex 5 2 2
MIRT539156 AREL1 apoptosis resistant E3 ubiquitin protein ligase 1 2 2
MIRT539474 ADARB2 adenosine deaminase, RNA specific B2 (inactive) 2 2
MIRT539620 SHISA9 shisa family member 9 2 2
MIRT539650 BUB1 BUB1 mitotic checkpoint serine/threonine kinase 2 2
MIRT540346 OPHN1 oligophrenin 1 2 2
MIRT540412 PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 2 2
MIRT541200 HSP90AA1 heat shock protein 90 alpha family class A member 1 2 2
MIRT541395 CDC27 cell division cycle 27 2 2
MIRT546443 SNX5 sorting nexin 5 2 2
MIRT547369 MSI2 musashi RNA binding protein 2 2 2
MIRT553288 TSPAN3 tetraspanin 3 2 2
MIRT554402 SERP1 stress associated endoplasmic reticulum protein 1 2 2
MIRT557822 FOXN2 forkhead box N2 2 2
MIRT568530 ANP32E acidic nuclear phosphoprotein 32 family member E 2 2
MIRT569508 THYN1 thymocyte nuclear protein 1 2 2
MIRT570707 FAM69A family with sequence similarity 69 member A 2 2
MIRT608376 PIWIL2 piwi like RNA-mediated gene silencing 2 2 2
MIRT608483 NKTR natural killer cell triggering receptor 2 6
MIRT613533 TRA2B transformer 2 beta homolog 2 2
MIRT616601 ELP2 elongator acetyltransferase complex subunit 2 2 2
MIRT618166 DUSP18 dual specificity phosphatase 18 2 2
MIRT632059 CEP135 centrosomal protein 135 2 2
MIRT647379 ZDHHC23 zinc finger DHHC-type containing 23 2 2
MIRT648366 POTED POTE ankyrin domain family member D 2 2
MIRT651075 ZNF518B zinc finger protein 518B 2 4
MIRT653618 SLC30A4 solute carrier family 30 member 4 2 2
MIRT653636 SLC30A1 solute carrier family 30 member 1 2 2
MIRT654895 POU2F1 POU class 2 homeobox 1 2 2
MIRT656232 MFSD6 major facilitator superfamily domain containing 6 2 2
MIRT659880 CAPRIN1 cell cycle associated protein 1 2 2
MIRT660526 ARL4C ADP ribosylation factor like GTPase 4C 2 2
MIRT666286 SLC30A3 solute carrier family 30 member 3 2 2
MIRT686808 SNX2 sorting nexin 2 2 4
MIRT695302 TK1 thymidine kinase 1 2 2
MIRT699737 SERINC3 serine incorporator 3 2 2
MIRT700794 PIAS2 protein inhibitor of activated STAT 2 2 2
MIRT712270 PPP1CB protein phosphatase 1 catalytic subunit beta 2 2
MIRT712617 KNSTRN kinetochore localized astrin/SPAG5 binding protein 2 2
MIRT714264 RPL10A ribosomal protein L10a 2 2
MIRT715072 TMTC1 transmembrane and tetratricopeptide repeat containing 1 2 2
MIRT715386 TADA3 transcriptional adaptor 3 2 2
MIRT716397 NPAS1 neuronal PAS domain protein 1 2 2
MIRT725328 NFASC neurofascin 2 2
MIRT725503 GANAB glucosidase II alpha subunit 2 2
MIRT732913 IRAK2 interleukin 1 receptor associated kinase 2 3 0
MIRT734890 SMAD3 SMAD family member 3 3 0
MIRT737328 LINC02476 long intergenic non-protein coding RNA 2476 3 0
MIRT737544 MALAT1 metastasis associated lung adenocarcinoma transcript 1 (non-protein coding) 4 0
MIRT755545 PAK1 p21 (RAC1) activated kinase 1 3 1
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-497 Bufalin NULL 9547215 Quantitative real-time PCR colorectal cancer HCT116 cells 24375248 2014 up-regulated
miR-497 Diethylstilbestrol approved 448537 Microarray mammosphere-derived epithelial cells (MDEC) 19549897 2009 up-regulated
miR-497 Ethanol NULL 702 Quantitative real-time PCR CIE10 22141737 2012 up-regulated
miR-497 Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) NULL 8490 Microarray mouse brain 19270793 2009 up-regulated
miR-497 Reversine NULL 210332 Microarray C2C12 myoblast cells 24513286 2014 down-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-497 Tamoxifen 2733525 NSC180973 approved sensitive Low Breast Cancer cell line (MCF-7, T47D)
hsa-mir-497 Dabrafenib 44462760 NSC764134 approved sensitive cell line (A375)
hsa-mir-497 Paclitaxel 36314 NSC125973 approved resistant cell line (W1)
hsa-mir-497 Cisplatin 5460033 NSC119875 approved resistant cell line (CIS)
hsa-mir-497 Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-mir-497 Androstenedione+Letrozole sensitive cell line (MCF-7)
hsa-mir-497 Tamoxifen 2733525 NSC180973 approved sensitive cell line (MCF7)
hsa-mir-497 Cisplatin 5460033 NSC119875 approved sensitive cell line (BxPC3)
hsa-miR-497-3p Mitoxantrone 4212 NSC279836 approved sensitive High Breast Cancer cell line (BT-20, BT-474, BT-549, CAMA-1, HCC1143, HCC1395, HCC1569, HCC1806, HCC-1937, HCC1954, HCC202, HCC38, HCC70, Hs578T, MCF-7, MDA-MB-175VII, MDA-MB-231, MDA-MB-361, MDA-MB-415, MDA-MB-436, MDA-MB-468, SKBR3, T47D, UACC812, EVSA-T, MPE-600 , SK-BR-
hsa-miR-497-3p Docetaxel 148124 NSC628503 approved resistant High Breast Cancer cell line (MDA-MB-231, MCF-7)
hsa-miR-497-3p Cisplatin 5460033 NSC119875 approved resistant High Non-Small Cell Lung Cancer cell line (A549, PC-9)
hsa-miR-497-3p Cisplatin 5460033 NSC119875 approved resistant Low Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-497-3p Gefitinib 123631 NSC715055 approved sensitive cell line (PC9)
hsa-miR-497-3p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-497-3p Cisplatin 5460033 NSC119875 approved resistant tissue
hsa-miR-497-3p Sunitinib 5329102 NSC750690 approved resistant tissue (CardB)
hsa-miR-497-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-497-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)

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