miRTarBase - #MIRT528860


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pre-miRNA Information
pre-miRNA hsa-mir-4650-1   
Genomic Coordinates chr7: 67114322 - 67114397
Description Homo sapiens miR-4650-1 stem-loop
Comment None
RNA Secondary Structure
pre-miRNA hsa-mir-4650-2   
Genomic Coordinates chr7: 72697903 - 72697978
Description Homo sapiens miR-4650-2 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4650-5p
Sequence 15| UCAGGCCUCUUUCUACCUU |33
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1332063492 8 dbSNP
rs914649075 9 dbSNP
rs1452034829 10 dbSNP
rs1489220537 15 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol PKP1   
Synonyms B6P
Description plakophilin 1
Transcript NM_000299   
Other Transcripts NM_001005337   
Expression
Putative miRNA Targets on PKP1
3'UTR of PKP1
(miRNA target sites are highlighted)		 
>PKP1|NM_000299|3'UTR
   1 GAAGAGACTGTCCAAGCAAGTTAGGCTTGCAGGAAGATATGACCCAGCTGAGAAGCCCTCAGGCCTCGCTGGATGGGGTT
  81 TTCTGTCCATCCTGTGCAGTATTTGGGAAAGTTCACAAGAAACTGAGAAGAAACCTAAAAACTGTGGATAGTGGAAAGAT
 161 TTTTAGATTTTTTTTTTCCTTGGGGAAACTGGCAGGCAATGGGGGTTAGGGAGGTTGGGGCGGGGGGGGCTTTCTTGAGT
 241 TAAAGGGGCTTATATGTGATGTCAATATTTCTTCCTCTGAGAAATGGTATATATATGTGTATAATGTAAGTGTGTGCATG
 321 CATGTGCGCGTGCATGTGTGTGTGTGTGAGTGTCTTAAAGCATAACCACAAACTGCAAAAAGCTAGGTAAGCTATTTTGT
 401 TGCAGCTCATAAGGTGGTGAAAAGGACTCTCCTGTGTTTCTTACTCATAGGCAAGGACAACATGTGCTTTTTGGTGAGCT
 481 GCTCATAATTCCTGAAATGTGTGGTGCCAGGGCAAGGGGGCCATCACTGCAGTCAGGCCCTCAGAGGAGTCCTGCAGGCT
 561 TCCTACCAGTGGTCTCCAGGGGTGCAGGAGTAACTGGGGCTGGGCCAGCCTCCCCACTTACAAGGCTGCTTTCCAGGAAG
 641 GGAGGTCTGGTGTATCTCATGGGAGAATCTGGGGTGTCTGTAATGTCACCCCTCCAGCAGCGCCACAAGGACTGAGGTTG
 721 GGTAGGTGTGGGGTTCCAGAGGACAGCAGGACACTCTCGCATACTTTGCCAAATGAGGCCTGCTCAGAGGAGTAGGAGCT
 801 GAAAGATGGTGCCTTCCACCCTCTTGGGCTGTGTGCCCATCAGAGCAGGCTCAGCCTGCAAAGGCCCTGCATTCAGAGGT
 881 CTTGTAATCTACTTGTTGCAGGAGAAAGAAGGTAAAAAATGATTTTTTTAAGAAAAGCTATTTTATTGCAGCTCTTTCCC
 961 AAGAGCTGTTCTGGGAATGGCTGGTCTTCATATTCCCAGTGGAGAGGGGAACAAGTGGGGCTGGGCATATACCTATTCCG
1041 GCTTCTAGTGGGATGGAGTTGGGGTATAGAAATTAACCAGGAAGATGTTTCCACCAAGCCTGCTGTGAGTCAATTGAGGG
1121 AGTGTTTGGGGTCCCAGGAGACTTGGACGGGGGGAGTTTGGGTAGACTAGGAAAGGAAAGTGCCATATCAGGGTACCGGT
1201 ACCGGCAAGCTCACATCTCAGCCAGGGGCCATGCCCCACTTCCCCTGACCCCAGCTGTCTTGTCTCCACTCTGTGAAACC
1281 CACAGGGGATGTGATAAACAGGGCTATTAGGGGTATCAGCCACGTCGAGCCCCCAGACTCTGTGCACTTCAGACCAGCAG
1361 CAGCAGGAGGGCTCCCGAGGGCCTTATGAGAAAACCTGTGTGGACATCCCTTGGTGTACACTAAGACAGAGCAGAGCCCA
1441 GCGCTCCCAAGCCTTCCTCCTTCCAGCTTCTACCTCCATGCTAGCATTGCTGGTGTTAGAGAGGAATTAACTTCCTGGTC
1521 TGTGCCCTTCTCTAGAAGAATATAAGATGCTCCTCCTCCTCACCCCTTCTCAGCCTCCTCCCAAGTCTTCCTCTTCTGCA
1601 CCACCCCCGAGTCCAAACCCACCTCTTGCCCCAGCATTCAGGCTGGAAAACACTGATGTGGACTCAGTATGATAACTGAG
1681 ATGGGGGACGCCAGACATGTGAGGACGCTGTCCTCCGAGAGGTGTCCCCGGCTGTTAGCCAGCTGTGCTGTGGTGCTGTG
1761 GGTCTGTCATACCCTCCCTTGCTTCTGTTCACACTGGGAGGCCCACTCCTGGCTCACCTCTCCCTCTCAGGGACCCACGT
1841 GGGAGCCTGGATCCCTGGACTGTCCTGGGCATAGGTTTCAGGGGCCTCCTTTGTTGTCATCAGAACCCAGAGGAATTCTT
1921 CTCCTAAAAAATACGTATGGCATACCAATCTGTGCGGGGCAGTGTCCTAAGCACTTAGACTACATCAGGGAAGAACACAG
2001 ACCACATCCCTGTCCTCATGCGGCTTATGTTTTCTGGAGGAAAGTGGAGACACAAGTCCTTGGCTTTAGGGCTCCCCCGG
2081 CTGGGGGCTGTGCAGTCCGGTCAGGGCGGGAGGGGAAATGCACCGCTGCATGTGAACCTTACCAGCCCAGGCGGATGCCC
2161 CTTCCCCTTAGCACTACCCTGGCCTCCTGCATCCCCTCGCCTCATGTTCCTCCCACCTTCAAAGAATGAAGAGCCCCATG
2241 GGCCCAGCCCCTGCCCTGGGAACCAGGCAGCCTTCCAGACCTCAGGGGCTGAGGCAGACTATTAGGGCAGGGCTGACTTT
2321 GGTGACACTGCCCATTCCCTCTCAGGCCAGCTCAGGTCACCCGGGCCTCTGACCCAGGCCTGTCACTTTGAGAGGGGCAA
2401 AACTGAGAGGGGCTTTTCCTAGAGAAAGAGAACAAGGAGCTTGCCAGGCTTCATGTAGCCGACACACGTCTCAGGATTTT
2481 AAGTCCACATTGGCCTCACACTACCAGGGCCAATGCCCAAAATAAGGAGTTCCAATTTGGGGCCAAATGAGGAAGGACAC
2561 AGACTCTGCCCTGGGATCTCCTGTGCTAGCGGCCAATGACAAATCCAGTCATTGGCCACCAGCCACCTCTGCAGTGGGGA
2641 CCACACTAGCAGCCCTGACTCCACACTCCTCCTGGGGACCCAAGAGGCAGTGTTGCTGTCTGCATGTCCACCTTGGAATC
2721 TGGCTGAACTGGCTGGCAGGACCAAGACTGCGGCTGGGGTGGGCAGGGAAGGGAAGCCGGGGGCTGCTGTGAGGGATCTT
2801 GGAGCTTCCCTGTAGCCCACCTTCCCCTTGCTTCATGTTTGTAGAGGAACCTTGTGCCGGCCAGGCCCAGTTTCCTTGTG
2881 TGATACACTAATGTATTTGCTTTTTTTGGAAATAGAGAAAATCAATAAATTGCTAGTGTTTCTTTGAACTTT
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' uuccaucUUUCUCCGGACu 5'
                 || |||||||| 
Target 5' tttgccaAATGAGGCCTGc 3'
 765 - 783 152.00 -13.80
2 
miRNA  3' uuccauCUUUCUCCGGACu 5'
                ||   ||||||| 
Target 5' gcctctGACCCAGGCCTGt 3'
 2365 - 2383 141.00 -11.70
3 
miRNA  3' uuccaUCUUU--CUCCGGACu 5'
               ||:||  ||||:||| 
Target 5' tttccAGGAAGGGAGGTCTGg 3'
 630 - 650 140.00 -18.40
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
294831 1262 ClinVar
294832 1269 ClinVar
294833 1357 ClinVar
294834 1373 ClinVar
294835 1398 ClinVar
874162 1427 ClinVar
294837 1428 ClinVar
294838 1428 ClinVar
294836 1430 ClinVar
294839 1507 ClinVar
294840 1526 ClinVar
294841 1533 ClinVar
294842 1535 ClinVar
294843 1555 ClinVar
294844 1623 ClinVar
294845 1653 ClinVar
876033 1654 ClinVar
294846 1785 ClinVar
294847 1822 ClinVar
294848 1850 ClinVar
294849 1879 ClinVar
294850 1879 ClinVar
294851 1889 ClinVar
294852 1915 ClinVar
877004 1919 ClinVar
294853 1924 ClinVar
294854 1937 ClinVar
874212 1947 ClinVar
874213 1992 ClinVar
294855 2062 ClinVar
874214 2067 ClinVar
294856 2070 ClinVar
874215 2100 ClinVar
875134 2102 ClinVar
294857 2130 ClinVar
875135 2139 ClinVar
294858 2238 ClinVar
294859 2246 ClinVar
875136 2270 ClinVar
875137 2338 ClinVar
294860 2354 ClinVar
294861 2403 ClinVar
876095 2409 ClinVar
294862 2435 ClinVar
294863 2511 ClinVar
294864 2615 ClinVar
876096 2649 ClinVar
294865 2704 ClinVar
294866 2722 ClinVar
294867 2761 ClinVar
877048 2764 ClinVar
294868 2771 ClinVar
294869 2810 ClinVar
294870 2849 ClinVar
294871 2879 ClinVar
294872 2895 ClinVar
294873 2922 ClinVar
874266 2936 ClinVar
294874 3018 ClinVar
294875 3090 ClinVar
294876 3148 ClinVar
874267 3487 ClinVar
294877 3568 ClinVar
875195 3614 ClinVar
875196 3666 ClinVar
875197 3707 ClinVar
294878 3711 ClinVar
294879 3733 ClinVar
294880 3748 ClinVar
294881 3749 ClinVar
294882 3765 ClinVar
294883 3774 ClinVar
294884 3774 ClinVar
876155 3797 ClinVar
294885 3829 ClinVar
294886 3910 ClinVar
294887 3943 ClinVar
294888 3958 ClinVar
294889 3984 ClinVar
876297 4011 ClinVar
294890 4056 ClinVar
294891 4064 ClinVar
294892 4065 ClinVar
COSN30191328 15 COSMIC
COSN30106756 30 COSMIC
COSN5852254 84 COSMIC
COSN28183435 161 COSMIC
COSN29338377 217 COSMIC
COSN6523735 389 COSMIC
COSN1426548 465 COSMIC
COSN1095986 655 COSMIC
COSN31989844 655 COSMIC
COSN24832777 999 COSMIC
COSN8428558 1242 COSMIC
COSN8428559 1243 COSMIC
COSN25819115 1418 COSMIC
COSN8428560 1448 COSMIC
COSN8428561 1501 COSMIC
COSN1426549 1756 COSMIC
COSN23543922 1778 COSMIC
COSN2525868 1879 COSMIC
COSN21734327 1948 COSMIC
COSN22755885 1949 COSMIC
COSN27833467 2135 COSMIC
COSN21993608 2348 COSMIC
COSN29394913 2791 COSMIC
COSN5736471 2856 COSMIC
COSN6019007 2904 COSMIC
COSN21185684 3143 COSMIC
COSN20090428 3364 COSMIC
COSN20095727 3777 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1441062455 2 dbSNP
rs747415292 13 dbSNP
rs1428400893 14 dbSNP
rs771192084 17 dbSNP
rs781530697 18 dbSNP
rs1172772289 21 dbSNP
rs370739529 26 dbSNP
rs769921106 30 dbSNP
rs1168465369 31 dbSNP
rs1161007261 36 dbSNP
rs775506442 42 dbSNP
rs1381736977 45 dbSNP
rs748104844 46 dbSNP
rs772039714 47 dbSNP
rs1437516318 50 dbSNP
rs371965671 54 dbSNP
rs1267705256 66 dbSNP
rs992637243 95 dbSNP
rs1359091456 99 dbSNP
rs543397782 103 dbSNP
rs564873258 110 dbSNP
rs1242572637 111 dbSNP
rs1354568142 112 dbSNP
rs1339136430 118 dbSNP
rs1306424109 125 dbSNP
rs553546540 126 dbSNP
rs951263155 129 dbSNP
rs567250883 131 dbSNP
rs1295143659 132 dbSNP
rs1405401233 137 dbSNP
rs1002665650 139 dbSNP
rs1298750725 150 dbSNP
rs1421105587 154 dbSNP
rs1035114345 167 dbSNP
rs960968524 176 dbSNP
rs867417073 187 dbSNP
rs1416733018 193 dbSNP
rs909877489 194 dbSNP
rs576073490 195 dbSNP
rs536125901 197 dbSNP
rs967314016 210 dbSNP
rs1264784557 212 dbSNP
rs1260301106 213 dbSNP
rs978591492 216 dbSNP
rs925813124 217 dbSNP
rs942548811 218 dbSNP
rs1224019877 224 dbSNP
rs1203372762 227 dbSNP
rs1301099901 231 dbSNP
rs1401566789 232 dbSNP
rs975542662 233 dbSNP
rs1287858702 235 dbSNP
rs1451087237 237 dbSNP
rs922388594 253 dbSNP
rs556154642 261 dbSNP
rs1233160816 262 dbSNP
rs576331677 269 dbSNP
rs933637034 274 dbSNP
rs756908517 283 dbSNP
rs1480379948 286 dbSNP
rs1427751926 288 dbSNP
rs1481318183 294 dbSNP
rs115830010 304 dbSNP
rs1488781657 313 dbSNP
rs1429147916 315 dbSNP
rs1481060710 316 dbSNP
rs1051194386 321 dbSNP
rs887357694 338 dbSNP
rs941649533 339 dbSNP
rs1203069286 344 dbSNP
rs1322761678 357 dbSNP
rs1038597768 359 dbSNP
rs1281239112 364 dbSNP
rs1220242612 368 dbSNP
rs905319571 373 dbSNP
rs369838627 377 dbSNP
rs1380151758 382 dbSNP
rs1572968 389 dbSNP
rs1336857014 390 dbSNP
rs1035487309 393 dbSNP
rs1173446355 394 dbSNP
rs1434356829 402 dbSNP
rs756114184 407 dbSNP
rs1344735274 409 dbSNP
rs896598584 413 dbSNP
rs572495585 417 dbSNP
rs1425812308 423 dbSNP
rs1257065452 424 dbSNP
rs894211716 427 dbSNP
rs1183081133 431 dbSNP
rs1459984591 432 dbSNP
rs1014125064 438 dbSNP
rs1200445174 442 dbSNP
rs1024135693 452 dbSNP
rs951368480 453 dbSNP
rs80328041 456 dbSNP
rs1213828135 468 dbSNP
rs1315229238 472 dbSNP
rs1273236813 474 dbSNP
rs532287103 482 dbSNP
rs1379919441 485 dbSNP
rs1021008304 489 dbSNP
rs1004545520 490 dbSNP
rs1410987352 491 dbSNP
rs561447593 500 dbSNP
rs978633894 503 dbSNP
rs1166538326 504 dbSNP
rs963052199 507 dbSNP
rs1386101925 511 dbSNP
rs1572969 520 dbSNP
rs921380127 521 dbSNP
rs1267567544 531 dbSNP
rs1240082950 535 dbSNP
rs1180479396 547 dbSNP
rs1438359412 557 dbSNP
rs955449977 563 dbSNP
rs1490636667 582 dbSNP
rs964188367 588 dbSNP
rs1193857955 591 dbSNP
rs986971283 596 dbSNP
rs187206490 597 dbSNP
rs1244756660 599 dbSNP
rs562505636 609 dbSNP
rs975300163 610 dbSNP
rs796226711 612 dbSNP
rs1310854281 614 dbSNP
rs922326021 615 dbSNP
rs1442236151 620 dbSNP
rs1202218558 621 dbSNP
rs945530187 626 dbSNP
rs531166831 627 dbSNP
rs1261728766 631 dbSNP
rs1388956732 643 dbSNP
rs1044380039 653 dbSNP
rs1163236954 654 dbSNP
rs933794711 655 dbSNP
rs1382365973 659 dbSNP
rs1159245140 664 dbSNP
rs551346007 674 dbSNP
rs749164446 675 dbSNP
rs1421865915 693 dbSNP
rs1490792506 696 dbSNP
rs1269291496 700 dbSNP
rs556804191 701 dbSNP
rs6697983 705 dbSNP
rs1361904 706 dbSNP
rs1014010284 711 dbSNP
rs1278355611 712 dbSNP
rs1236042451 713 dbSNP
rs1366272350 714 dbSNP
rs1346587432 719 dbSNP
rs1045475177 725 dbSNP
rs1038566244 733 dbSNP
rs1403442869 734 dbSNP
rs886956836 737 dbSNP
rs926909689 738 dbSNP
rs1304857564 744 dbSNP
rs938165607 744 dbSNP
rs748383230 745 dbSNP
rs896561772 754 dbSNP
rs1405852404 755 dbSNP
rs1017289315 756 dbSNP
rs1481394921 767 dbSNP
rs1429851094 772 dbSNP
rs6685490 779 dbSNP
rs1270571390 796 dbSNP
rs1042505523 802 dbSNP
rs1243558220 806 dbSNP
rs1216049844 812 dbSNP
rs903830540 813 dbSNP
rs1226260388 814 dbSNP
rs1426730847 824 dbSNP
rs773374504 825 dbSNP
rs1204978207 837 dbSNP
rs1033327568 838 dbSNP
rs1283143658 840 dbSNP
rs548296273 843 dbSNP
rs1342755149 845 dbSNP
rs572436125 846 dbSNP
rs6660897 850 dbSNP
rs1430236418 852 dbSNP
rs1284464876 853 dbSNP
rs1336270273 856 dbSNP
rs913958661 861 dbSNP
rs1175615392 864 dbSNP
rs1361903 871 dbSNP
rs955391744 875 dbSNP
rs1421361196 881 dbSNP
rs1194273771 882 dbSNP
rs979604857 896 dbSNP
rs769064314 898 dbSNP
rs1361902 903 dbSNP
rs141138478 922 dbSNP
rs973739130 924 dbSNP
rs1055507193 933 dbSNP
rs1263122311 935 dbSNP
rs915581748 939 dbSNP
rs775945333 948 dbSNP
rs35176662 956 dbSNP
rs1446491498 958 dbSNP
rs1214299738 959 dbSNP
rs1360148975 963 dbSNP
rs938318016 970 dbSNP
rs558910609 971 dbSNP
rs1453556242 972 dbSNP
rs761587162 974 dbSNP
rs762265958 975 dbSNP
rs768053236 988 dbSNP
rs6698269 989 dbSNP
rs1346738611 993 dbSNP
rs1450252465 1006 dbSNP
rs1313893625 1009 dbSNP
rs1356169780 1010 dbSNP
rs945532838 1010 dbSNP
rs898447849 1018 dbSNP
rs1042464741 1020 dbSNP
rs572479145 1021 dbSNP
rs1165067850 1025 dbSNP
rs1028161224 1027 dbSNP
rs1247482164 1033 dbSNP
rs903964792 1035 dbSNP
rs1361901 1036 dbSNP
rs1206235143 1046 dbSNP
rs969628293 1047 dbSNP
rs61819984 1052 dbSNP
rs899746007 1053 dbSNP
rs1441029407 1059 dbSNP
rs1233904633 1070 dbSNP
rs996737531 1081 dbSNP
rs1306121974 1084 dbSNP
rs118171556 1101 dbSNP
rs955179248 1105 dbSNP
rs1358868864 1106 dbSNP
rs1243936363 1109 dbSNP
rs1393165974 1111 dbSNP
rs980041460 1117 dbSNP
rs1004020456 1121 dbSNP
rs1441301007 1124 dbSNP
rs544135334 1134 dbSNP
rs959488168 1136 dbSNP
rs1424934493 1138 dbSNP
rs1384164656 1144 dbSNP
rs1161147259 1146 dbSNP
rs962463354 1147 dbSNP
rs532188035 1148 dbSNP
rs6700827 1150 dbSNP
rs753889373 1151 dbSNP
rs949724552 1162 dbSNP
rs1468008486 1168 dbSNP
rs1223634810 1170 dbSNP
rs1490255091 1173 dbSNP
rs1289793784 1188 dbSNP
rs1335875036 1188 dbSNP
rs1241285180 1193 dbSNP
rs1406293902 1198 dbSNP
rs959298202 1211 dbSNP
rs992386689 1213 dbSNP
rs1217652476 1215 dbSNP
rs918184630 1227 dbSNP
rs1307673398 1243 dbSNP
rs1279909878 1255 dbSNP
rs1223108853 1256 dbSNP
rs886045812 1262 dbSNP
rs908324390 1263 dbSNP
rs886045813 1269 dbSNP
rs758301018 1271 dbSNP
rs1334648972 1273 dbSNP
rs150757816 1274 dbSNP
rs1345247264 1280 dbSNP
rs1159067922 1283 dbSNP
rs1417888394 1284 dbSNP
rs939785482 1295 dbSNP
rs947374 1300 dbSNP
rs1480277771 1305 dbSNP
rs1267125940 1306 dbSNP
rs1322075085 1307 dbSNP
rs1486256243 1321 dbSNP
rs1260246850 1330 dbSNP
rs1213665427 1335 dbSNP
rs925352333 1346 dbSNP
rs1327009078 1352 dbSNP
rs1223232743 1354 dbSNP
rs936779688 1355 dbSNP
rs79906867 1357 dbSNP
rs932456506 1365 dbSNP
rs1196975329 1370 dbSNP
rs1049648633 1373 dbSNP
rs1250143956 1373 dbSNP
rs1362173563 1373 dbSNP
rs886045814 1373 dbSNP
rs1455135307 1374 dbSNP
rs891022769 1378 dbSNP
rs1177786632 1379 dbSNP
rs1250145386 1384 dbSNP
rs1438441496 1385 dbSNP
rs1184124841 1387 dbSNP
rs1427597601 1388 dbSNP
rs1008209946 1393 dbSNP
rs1429357673 1397 dbSNP
rs114649649 1398 dbSNP
rs1479427729 1403 dbSNP
rs1175371904 1406 dbSNP
rs1429730620 1418 dbSNP
rs752451518 1420 dbSNP
rs1000960081 1421 dbSNP
rs1200258224 1422 dbSNP
rs1204196165 1422 dbSNP
rs1470867356 1425 dbSNP
rs201366172 1426 dbSNP
rs386638476 1427 dbSNP
rs547062578 1427 dbSNP
rs758358539 1427 dbSNP
rs886045815 1427 dbSNP
rs7541805 1428 dbSNP
rs959546140 1429 dbSNP
rs947375 1430 dbSNP
rs1372788891 1432 dbSNP
rs1344115937 1433 dbSNP
rs1025259763 1434 dbSNP
rs1284553785 1435 dbSNP
rs942629067 1436 dbSNP
rs1326082291 1441 dbSNP
rs900467095 1442 dbSNP
rs1339828803 1443 dbSNP
rs1225755971 1446 dbSNP
rs1250938194 1453 dbSNP
rs1250473076 1454 dbSNP
rs1340359372 1454 dbSNP
rs933330011 1455 dbSNP
rs1197579736 1467 dbSNP
rs1050999217 1471 dbSNP
rs1490226300 1493 dbSNP
rs908207719 1493 dbSNP
rs1198584819 1500 dbSNP
rs891065407 1501 dbSNP
rs184565243 1504 dbSNP
rs947376 1507 dbSNP
rs1426823865 1508 dbSNP
rs932508958 1509 dbSNP
rs1163024776 1512 dbSNP
rs1471814318 1524 dbSNP
rs886045816 1526 dbSNP
rs898246005 1528 dbSNP
rs1438235850 1529 dbSNP
rs188228781 1533 dbSNP
rs746397073 1534 dbSNP
rs886045817 1535 dbSNP
rs547359724 1536 dbSNP
rs552326541 1538 dbSNP
rs1053898649 1539 dbSNP
rs142978010 1540 dbSNP
rs1491298339 1540 dbSNP
rs895220756 1540 dbSNP
rs1286871898 1545 dbSNP
rs1012456084 1551 dbSNP
rs1423511746 1555 dbSNP
rs886045818 1555 dbSNP
rs1304254710 1563 dbSNP
rs1025220519 1573 dbSNP
rs1025147060 1578 dbSNP
rs1380844741 1590 dbSNP
rs970847520 1606 dbSNP
rs1005144597 1612 dbSNP
rs1160273832 1616 dbSNP
rs1470482246 1619 dbSNP
rs566048359 1623 dbSNP
rs1179750164 1628 dbSNP
rs770381696 1634 dbSNP
rs978254447 1636 dbSNP
rs1015564708 1637 dbSNP
rs961087637 1642 dbSNP
rs886045819 1653 dbSNP
rs925402795 1654 dbSNP
rs1220344279 1658 dbSNP
rs372822124 1661 dbSNP
rs796938287 1662 dbSNP
rs936832075 1670 dbSNP
rs919705113 1691 dbSNP
rs1205154191 1711 dbSNP
rs974826587 1714 dbSNP
rs1229892755 1716 dbSNP
rs776035292 1724 dbSNP
rs1289940242 1727 dbSNP
rs933317251 1731 dbSNP
rs1358792429 1737 dbSNP
rs1052226731 1739 dbSNP
rs1434547066 1744 dbSNP
rs1292361590 1745 dbSNP
rs1328388119 1753 dbSNP
rs1489438047 1771 dbSNP
rs10920174 1785 dbSNP
rs1400120807 1796 dbSNP
rs1387900443 1805 dbSNP
rs1156837757 1814 dbSNP
rs1470861336 1817 dbSNP
rs1429692655 1818 dbSNP
rs943835264 1819 dbSNP
rs1042320816 1820 dbSNP
rs1260787751 1821 dbSNP
rs2365648 1822 dbSNP
rs537686660 1824 dbSNP
rs1324769820 1826 dbSNP
rs1278403630 1848 dbSNP
rs886045820 1850 dbSNP
rs1036910433 1853 dbSNP
rs1341738133 1856 dbSNP
rs1054189388 1858 dbSNP
rs1363088432 1860 dbSNP
rs898298191 1861 dbSNP
rs1318503295 1876 dbSNP
rs866540543 1876 dbSNP
rs1454541994 1877 dbSNP
rs1406665881 1878 dbSNP
rs74504311 1879 dbSNP
rs1421292642 1886 dbSNP
rs1105331 1889 dbSNP
rs1443444800 1891 dbSNP
rs1163699502 1894 dbSNP
rs1245637556 1894 dbSNP
rs894918800 1895 dbSNP
rs1013246074 1896 dbSNP
rs1452277155 1898 dbSNP
rs1208540836 1901 dbSNP
rs1024687170 1902 dbSNP
rs1288587023 1907 dbSNP
rs1439918181 1908 dbSNP
rs1274028898 1914 dbSNP
rs3795628 1915 dbSNP
rs1340245296 1916 dbSNP
rs181019805 1919 dbSNP
rs1032608205 1922 dbSNP
rs1302178583 1923 dbSNP
rs184294871 1924 dbSNP
rs975340262 1929 dbSNP
rs758179057 1930 dbSNP
rs540738012 1931 dbSNP
rs3795629 1937 dbSNP
rs1387890901 1939 dbSNP
rs529739628 1948 dbSNP
rs953673273 1956 dbSNP
rs1444708052 1963 dbSNP
rs879432693 1964 dbSNP
rs985183680 1965 dbSNP
rs1233841098 1967 dbSNP
rs1204837949 1970 dbSNP
rs987429497 1981 dbSNP
rs912284250 1983 dbSNP
rs771075412 1989 dbSNP
rs149894452 1992 dbSNP
rs1260137026 2007 dbSNP
rs978316257 2008 dbSNP
rs1375374902 2011 dbSNP
rs1288779781 2015 dbSNP
rs190014563 2021 dbSNP
rs919860104 2023 dbSNP
rs1210404379 2027 dbSNP
rs931150699 2030 dbSNP
rs28602515 2031 dbSNP
rs1304581399 2033 dbSNP
rs936582829 2047 dbSNP
rs1162036873 2060 dbSNP
rs1104755 2062 dbSNP
rs61819986 2070 dbSNP
rs1013714075 2071 dbSNP
rs1046188502 2072 dbSNP
rs1471807276 2077 dbSNP
rs902151577 2093 dbSNP
rs1488224669 2094 dbSNP
rs999210261 2099 dbSNP
rs566087080 2100 dbSNP
rs1415339762 2101 dbSNP
rs181273328 2102 dbSNP
rs1268680637 2114 dbSNP
rs1036929022 2115 dbSNP
rs1348364885 2117 dbSNP
rs1284860410 2119 dbSNP
rs899452615 2128 dbSNP
rs3795630 2130 dbSNP
rs1029165871 2135 dbSNP
rs1454840941 2139 dbSNP
rs1346367345 2146 dbSNP
rs1159068491 2148 dbSNP
rs1364919837 2164 dbSNP
rs1456011993 2166 dbSNP
rs1455632434 2168 dbSNP
rs1029614429 2171 dbSNP
rs1431872817 2173 dbSNP
rs1335165418 2181 dbSNP
rs1432849337 2182 dbSNP
rs889463649 2183 dbSNP
rs1188368546 2184 dbSNP
rs1454888580 2191 dbSNP
rs1006488733 2196 dbSNP
rs111378582 2206 dbSNP
rs568596167 2214 dbSNP
rs1453658341 2215 dbSNP
rs965493777 2221 dbSNP
rs987481670 2223 dbSNP
rs1371265264 2225 dbSNP
rs977991558 2230 dbSNP
rs907976068 2231 dbSNP
rs147193741 2238 dbSNP
rs1311265211 2239 dbSNP
rs973406926 2245 dbSNP
rs774719541 2246 dbSNP
rs1383481355 2248 dbSNP
rs554671472 2250 dbSNP
rs760268759 2254 dbSNP
rs186112428 2262 dbSNP
rs1433554532 2264 dbSNP
rs765354486 2270 dbSNP
rs931264055 2278 dbSNP
rs6667284 2282 dbSNP
rs1055055086 2284 dbSNP
rs770579345 2289 dbSNP
rs557286579 2291 dbSNP
rs577340063 2308 dbSNP
rs1238892968 2320 dbSNP
rs1479353709 2328 dbSNP
rs1172767467 2329 dbSNP
rs1429248943 2332 dbSNP
rs1176155769 2338 dbSNP
rs1046156842 2340 dbSNP
rs948057796 2348 dbSNP
rs1463494521 2350 dbSNP
rs140478008 2354 dbSNP
rs940767552 2354 dbSNP
rs759026826 2355 dbSNP
rs553211179 2356 dbSNP
rs573192326 2360 dbSNP
rs899336916 2361 dbSNP
rs1053483359 2362 dbSNP
rs1296266733 2365 dbSNP
rs930783810 2367 dbSNP
rs1385633468 2374 dbSNP
rs1050655052 2383 dbSNP
rs1395854803 2388 dbSNP
rs1400493651 2389 dbSNP
rs1473864316 2391 dbSNP
rs1370117536 2397 dbSNP
rs889352700 2397 dbSNP
rs540651814 2403 dbSNP
rs560541017 2404 dbSNP
rs1423078409 2408 dbSNP
rs574230662 2409 dbSNP
rs543461764 2410 dbSNP
rs1030723075 2412 dbSNP
rs958130930 2417 dbSNP
rs1470538365 2419 dbSNP
rs955013267 2421 dbSNP
rs574365899 2423 dbSNP
rs1009037211 2430 dbSNP
rs1014940698 2433 dbSNP
rs1244731737 2434 dbSNP
rs775406062 2435 dbSNP
rs1353021202 2441 dbSNP
rs1441520685 2445 dbSNP
rs973375871 2466 dbSNP
rs1350165579 2468 dbSNP
rs969283878 2470 dbSNP
rs1373897971 2478 dbSNP
rs1028031270 2479 dbSNP
rs958743350 2480 dbSNP
rs1162687348 2488 dbSNP
rs1411593421 2489 dbSNP
rs35917356 2490 dbSNP
rs991117325 2495 dbSNP
rs1366574538 2501 dbSNP
rs1184092614 2504 dbSNP
rs927955689 2505 dbSNP
rs1281374694 2507 dbSNP
rs1344624250 2509 dbSNP
rs188915730 2511 dbSNP
rs972569913 2514 dbSNP
rs1490725531 2516 dbSNP
rs1280249895 2517 dbSNP
rs920666063 2519 dbSNP
rs543331730 2520 dbSNP
rs1263006600 2527 dbSNP
rs532301718 2529 dbSNP
rs981970181 2532 dbSNP
rs1203134390 2533 dbSNP
rs1251383768 2535 dbSNP
rs1350221938 2543 dbSNP
rs1286743340 2545 dbSNP
rs930836278 2551 dbSNP
rs923677554 2556 dbSNP
rs368916010 2558 dbSNP
rs1322977846 2563 dbSNP
rs935106619 2566 dbSNP
rs1385091110 2572 dbSNP
rs1388560932 2577 dbSNP
rs1053543004 2580 dbSNP
rs763813288 2582 dbSNP
rs552073129 2583 dbSNP
rs1410991110 2587 dbSNP
rs1156640562 2592 dbSNP
rs1040597569 2593 dbSNP
rs1051091466 2597 dbSNP
rs890735356 2601 dbSNP
rs1480952541 2606 dbSNP
rs900850230 2606 dbSNP
rs1009014528 2607 dbSNP
rs1193318701 2608 dbSNP
rs559713296 2609 dbSNP
rs528393015 2610 dbSNP
rs1417579779 2611 dbSNP
rs886045821 2615 dbSNP
rs1329023372 2619 dbSNP
rs898002222 2622 dbSNP
rs994849297 2624 dbSNP
rs548644290 2627 dbSNP
rs1274470678 2632 dbSNP
rs568423815 2640 dbSNP
rs958934881 2641 dbSNP
rs1372481655 2643 dbSNP
rs751325066 2648 dbSNP
rs530912477 2649 dbSNP
rs1023468753 2663 dbSNP
rs969170447 2664 dbSNP
rs991529754 2686 dbSNP
rs1023961611 2691 dbSNP
rs1425515586 2696 dbSNP
rs970665996 2699 dbSNP
rs1171607740 2700 dbSNP
rs981939058 2701 dbSNP
rs767755021 2703 dbSNP
rs886045822 2704 dbSNP
rs1405277296 2705 dbSNP
rs962370808 2707 dbSNP
rs866120795 2709 dbSNP
rs1246664371 2712 dbSNP
rs886045823 2722 dbSNP
rs920710686 2723 dbSNP
rs935158218 2728 dbSNP
rs1217663859 2736 dbSNP
rs989605228 2747 dbSNP
rs915014058 2753 dbSNP
rs181971047 2754 dbSNP
rs1227688764 2756 dbSNP
rs1359345023 2760 dbSNP
rs12564605 2761 dbSNP
rs886045824 2771 dbSNP
rs1359502935 2772 dbSNP
rs1295917540 2788 dbSNP
rs1333204131 2788 dbSNP
rs1412432313 2793 dbSNP
rs944922588 2798 dbSNP
rs1343646188 2803 dbSNP
rs1448332174 2804 dbSNP
rs750904335 2808 dbSNP
rs886045825 2810 dbSNP
rs897971113 2814 dbSNP
rs995035686 2815 dbSNP
rs756694170 2822 dbSNP
rs540057964 2826 dbSNP
rs780773900 2828 dbSNP
rs553127390 2831 dbSNP
rs893597527 2832 dbSNP
rs1010660883 2835 dbSNP
rs566868682 2841 dbSNP
rs1044802316 2842 dbSNP
rs1475331393 2848 dbSNP
rs548099839 2849 dbSNP
rs1392311575 2851 dbSNP
rs1379753038 2852 dbSNP
rs147846879 2858 dbSNP
rs1283383959 2872 dbSNP
rs1442814925 2875 dbSNP
rs10920175 2879 dbSNP
rs1024348714 2883 dbSNP
rs1364824507 2888 dbSNP
rs1405885748 2891 dbSNP
rs1308252958 2892 dbSNP
rs10800772 2895 dbSNP
rs1166223627 2909 dbSNP
rs961974311 2910 dbSNP
rs993944645 2912 dbSNP
rs370255022 2913 dbSNP
rs1003425663 2921 dbSNP
rs543171855 2922 dbSNP
rs1252863038 2923 dbSNP
rs1181705310 2929 dbSNP
rs1366961064 2930 dbSNP
rs557055659 2933 dbSNP
rs767259490 2935 dbSNP
rs186347223 2936 dbSNP
rs1313755827 2940 dbSNP
rs1231294504 2948 dbSNP
rs1360712784 2954 dbSNP
rs1288640767 2956 dbSNP
rs956500716 2957 dbSNP
rs1408861139 2959 dbSNP
rs1370643846 2962 dbSNP
rs966208002 2968 dbSNP
rs989350180 2987 dbSNP
rs565992887 2993 dbSNP
rs914959328 2998 dbSNP
rs111972864 3000 dbSNP
rs953198068 3006 dbSNP
rs1413192182 3007 dbSNP
rs569836518 3008 dbSNP
rs546026631 3009 dbSNP
rs1216993897 3014 dbSNP
rs1269662059 3017 dbSNP
rs149146601 3018 dbSNP
rs1191904293 3023 dbSNP
rs1488195121 3024 dbSNP
rs1246090951 3030 dbSNP
rs1211715065 3037 dbSNP
rs1466158823 3044 dbSNP
rs1250081426 3045 dbSNP
rs934924155 3051 dbSNP
rs1460160467 3052 dbSNP
rs1302954933 3059 dbSNP
rs1219350743 3063 dbSNP
rs1366262796 3066 dbSNP
rs1323253592 3072 dbSNP
rs1182990150 3089 dbSNP
rs17425876 3090 dbSNP
rs1389932596 3091 dbSNP
rs542099387 3092 dbSNP
rs1164901156 3100 dbSNP
rs914917462 3101 dbSNP
rs944390825 3106 dbSNP
rs1036549766 3109 dbSNP
rs919535031 3121 dbSNP
rs1044854647 3140 dbSNP
rs930794063 3141 dbSNP
rs12120834 3148 dbSNP
rs1248556858 3158 dbSNP
rs530899848 3161 dbSNP
rs550683577 3162 dbSNP
rs570950686 3166 dbSNP
rs1012963523 3178 dbSNP
rs1278264118 3179 dbSNP
rs750724022 3180 dbSNP
rs533262328 3183 dbSNP
rs897614369 3188 dbSNP
rs993436702 3190 dbSNP
rs1270421241 3192 dbSNP
rs1045857835 3194 dbSNP
rs887798512 3196 dbSNP
rs1203251874 3203 dbSNP
rs1244025193 3209 dbSNP
rs907173066 3225 dbSNP
rs546829203 3227 dbSNP
rs1030903406 3228 dbSNP
rs1017674236 3231 dbSNP
rs1465756632 3233 dbSNP
rs956635081 3236 dbSNP
rs1373787844 3246 dbSNP
rs775459519 3253 dbSNP
rs966148902 3256 dbSNP
rs1011146227 3269 dbSNP
rs566681109 3278 dbSNP
rs1159544762 3282 dbSNP
rs1426616782 3284 dbSNP
rs535746677 3285 dbSNP
rs555608868 3289 dbSNP
rs569437745 3291 dbSNP
rs1482731125 3294 dbSNP
rs956367414 3295 dbSNP
rs762342960 3304 dbSNP
rs537080365 3305 dbSNP
rs946387755 3313 dbSNP
rs763694572 3314 dbSNP
rs1395796016 3316 dbSNP
rs971733624 3329 dbSNP
rs556681725 3330 dbSNP
rs919502435 3331 dbSNP
rs930949421 3332 dbSNP
rs1370054108 3333 dbSNP
rs142266525 3334 dbSNP
rs773829671 3349 dbSNP
rs916045608 3353 dbSNP
rs545874700 3358 dbSNP
rs897671288 3359 dbSNP
rs1410967760 3363 dbSNP
rs929109726 3370 dbSNP
rs1048992185 3374 dbSNP
rs887685274 3377 dbSNP
rs948911735 3386 dbSNP
rs1483148616 3392 dbSNP
rs553208011 3395 dbSNP
rs1193499463 3401 dbSNP
rs1017553349 3402 dbSNP
rs901803861 3404 dbSNP
rs374781187 3405 dbSNP
rs1333126055 3408 dbSNP
rs761543114 3410 dbSNP
rs1347430084 3424 dbSNP
rs1410701452 3431 dbSNP
rs929326350 3437 dbSNP
rs956252590 3443 dbSNP
rs369086799 3444 dbSNP
rs1438535645 3446 dbSNP
rs1021914974 3448 dbSNP
rs893131938 3449 dbSNP
rs1182796808 3453 dbSNP
rs1472715311 3459 dbSNP
rs1362797460 3470 dbSNP
rs1179134815 3473 dbSNP
rs1452807038 3477 dbSNP
rs1253953726 3484 dbSNP
rs1268730415 3484 dbSNP
rs1010792641 3487 dbSNP
rs980310211 3493 dbSNP
rs926316093 3494 dbSNP
rs1377784017 3498 dbSNP
rs960621995 3501 dbSNP
rs767928690 3510 dbSNP
rs1165858579 3523 dbSNP
rs1395124370 3528 dbSNP
rs542160718 3534 dbSNP
rs1331731559 3535 dbSNP
rs918982446 3543 dbSNP
rs750814319 3552 dbSNP
rs888933640 3559 dbSNP
rs529824032 3562 dbSNP
rs1429886167 3563 dbSNP
rs1457559174 3567 dbSNP
rs77409791 3568 dbSNP
rs1018637505 3569 dbSNP
rs1038895997 3573 dbSNP
rs191912888 3574 dbSNP
rs901858776 3577 dbSNP
rs1453130768 3596 dbSNP
rs1250434250 3598 dbSNP
rs867322740 3600 dbSNP
rs1446751666 3602 dbSNP
rs1332987811 3609 dbSNP
rs1282479994 3617 dbSNP
rs971702680 3627 dbSNP
rs1345923648 3630 dbSNP
rs544640019 3633 dbSNP
rs1325281767 3637 dbSNP
rs951809824 3646 dbSNP
rs985030238 3647 dbSNP
rs891862609 3654 dbSNP
rs1389530205 3656 dbSNP
rs1342936615 3661 dbSNP
rs1207431475 3664 dbSNP
rs1315919883 3664 dbSNP
rs916166946 3666 dbSNP
rs1402402394 3673 dbSNP
rs1489842920 3674 dbSNP
rs1221374814 3675 dbSNP
rs1392612431 3699 dbSNP
rs1267783029 3700 dbSNP
rs534611777 3702 dbSNP
rs61819987 3711 dbSNP
rs151236820 3721 dbSNP
rs1372184494 3723 dbSNP
rs1443225114 3726 dbSNP
rs1449495990 3727 dbSNP
rs1279861238 3728 dbSNP
rs928695343 3729 dbSNP
rs12143423 3733 dbSNP
rs1036328059 3737 dbSNP
rs992220575 3743 dbSNP
rs1361110542 3746 dbSNP
rs58828153 3748 dbSNP
rs140498940 3749 dbSNP
rs1340770717 3756 dbSNP
rs1311868847 3758 dbSNP
rs950466178 3764 dbSNP
rs563345525 3765 dbSNP
rs1168621373 3766 dbSNP
rs1317871446 3768 dbSNP
rs1417920322 3770 dbSNP
rs909060591 3772 dbSNP
rs139473144 3774 dbSNP
rs200445704 3774 dbSNP
rs61710598 3777 dbSNP
rs183009669 3784 dbSNP
rs1252633890 3786 dbSNP
rs145675260 3790 dbSNP
rs923163449 3792 dbSNP
rs1358898731 3795 dbSNP
rs1243959717 3796 dbSNP
rs889060249 3797 dbSNP
rs138426889 3800 dbSNP
rs1018774104 3802 dbSNP
rs1351875613 3804 dbSNP
rs1308124505 3809 dbSNP
rs1246973142 3811 dbSNP
rs1465075933 3814 dbSNP
rs901686318 3818 dbSNP
rs34347167 3826 dbSNP
rs550560601 3829 dbSNP
rs1406412462 3831 dbSNP
rs1043133055 3832 dbSNP
rs1046941 3835 dbSNP
rs906047941 3845 dbSNP
rs1412962477 3846 dbSNP
rs1001684347 3847 dbSNP
rs1026496332 3852 dbSNP
rs1223701831 3861 dbSNP
rs1013290834 3865 dbSNP
rs951722412 3870 dbSNP
rs1272317795 3872 dbSNP
rs1231164451 3887 dbSNP
rs1370745383 3893 dbSNP
rs1026399987 3904 dbSNP
rs1307254983 3907 dbSNP
rs1222746632 3908 dbSNP
rs1046962 3910 dbSNP
rs1158377400 3915 dbSNP
rs1389568055 3921 dbSNP
rs1442292433 3928 dbSNP
rs1437540235 3929 dbSNP
rs1394316633 3938 dbSNP
rs1324371647 3939 dbSNP
rs1459156195 3941 dbSNP
rs1046970 3943 dbSNP
rs1245909552 3944 dbSNP
rs1158631443 3945 dbSNP
rs868721893 3954 dbSNP
rs1015945378 3955 dbSNP
rs964539124 3957 dbSNP
rs73074694 3958 dbSNP
rs572958352 3960 dbSNP
rs866888214 3963 dbSNP
rs1211658484 3964 dbSNP
rs933820044 3966 dbSNP
rs923248101 3969 dbSNP
rs1214674018 3984 dbSNP
rs886045826 3984 dbSNP
rs1314697075 3985 dbSNP
rs928756063 3988 dbSNP
rs988705722 3995 dbSNP
rs1234366453 4010 dbSNP
rs1236536615 4014 dbSNP
rs1371001865 4021 dbSNP
rs1301845019 4027 dbSNP
rs34464854 4029 dbSNP
rs1437790217 4032 dbSNP
rs934831190 4033 dbSNP
rs528128177 4042 dbSNP
rs1288612076 4043 dbSNP
rs1329695590 4043 dbSNP
rs914666969 4050 dbSNP
rs1240945575 4053 dbSNP
rs535674127 4056 dbSNP
rs1434178354 4057 dbSNP
rs1394445213 4058 dbSNP
rs1191644560 4063 dbSNP
rs555268205 4064 dbSNP
rs886045827 4065 dbSNP
rs1484722168 4066 dbSNP
rs575534035 4067 dbSNP
rs1211034227 4076 dbSNP
rs1057482561 4081 dbSNP
rs1346496422 4096 dbSNP
rs943251354 4097 dbSNP
rs1417869143 4098 dbSNP
rs1040275138 4100 dbSNP
rs895943317 4112 dbSNP
rs901655074 4118 dbSNP
rs993308638 4125 dbSNP
rs1295320140 4136 dbSNP
rs1025869387 4150 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions hESCs (WA-09)
Disease 5317.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in SRR359787. RNA binding protein: AGO2. Condition:4-thiouridine ...

- Lipchina I; Elkabetz Y; Hafner M; Sheridan et al., 2011, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' uuccaUCUUUCUCC-GGACu 5'
               ||:|: |||  ||| 
Target 5' cucagAGGAGUAGGAGCUGa 3'
 		2 - 21
Article - Lipchina I; Elkabetz Y; Hafner M; Sheridan et al.
- Genes & development, 2011
MicroRNAs are important regulators in many cellular processes, including stem cell self-renewal. Recent studies demonstrated their function as pluripotency factors with the capacity for somatic cell reprogramming. However, their role in human embryonic stem (ES) cells (hESCs) remains poorly understood, partially due to the lack of genome-wide strategies to identify their targets. Here, we performed comprehensive microRNA profiling in hESCs and in purified neural and mesenchymal derivatives. Using a combination of AGO cross-linking and microRNA perturbation experiments, together with computational prediction, we identified the targets of the miR-302/367 cluster, the most abundant microRNAs in hESCs. Functional studies identified novel roles of miR-302/367 in maintaining pluripotency and regulating hESC differentiation. We show that in addition to its role in TGF-beta signaling, miR-302/367 promotes bone morphogenetic protein (BMP) signaling by targeting BMP inhibitors TOB2, DAZAP2, and SLAIN1. This study broadens our understanding of microRNA function in hESCs and is a valuable resource for future studies in this area.
LinkOut: [PMID: 22012620]
CLIP-seq Support 1 for dataset SRR359787
Method / RBP PAR-CLIP / AGO2
Cell line / Condition hESCs (WA-09) / 4-thiouridine, RNase T1
Location of target site ENST00000367324.3 | 3UTR | GCUCAGAGGAGUAGGAGCUGAAAGAUGGUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22012620 / SRX103431
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
62 hsa-miR-4650-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT064263 KIAA1804 mitogen-activated protein kinase kinase kinase 21 2 2
MIRT082508 CALM3 calmodulin 3 2 10
MIRT456061 SLC25A28 solute carrier family 25 member 28 2 2
MIRT463521 ZBTB7B zinc finger and BTB domain containing 7B 2 2
MIRT465449 TP53 tumor protein p53 2 2
MIRT469517 RBFOX2 RNA binding protein, fox-1 homolog 2 2 8
MIRT470967 PKM pyruvate kinase, muscle 2 2
MIRT471902 NUAK2 NUAK family kinase 2 2 2
MIRT479924 CBX5 chromobox 5 2 2
MIRT483045 C15orf52 chromosome 15 open reading frame 52 2 13
MIRT493184 MKNK2 MAP kinase interacting serine/threonine kinase 2 2 2
MIRT496615 IKZF2 IKAROS family zinc finger 2 2 2
MIRT496980 DNAJC27 DnaJ heat shock protein family (Hsp40) member C27 2 2
MIRT522489 MFSD9 major facilitator superfamily domain containing 9 2 2
MIRT527859 SMOC1 SPARC related modular calcium binding 1 2 2
MIRT528540 TTC22 tetratricopeptide repeat domain 22 2 2
MIRT528860 PKP1 plakophilin 1 2 2
MIRT529389 NSFL1C NSFL1 cofactor 2 2
MIRT533523 TRIM13 tripartite motif containing 13 2 2
MIRT538056 DNAH3 dynein axonemal heavy chain 3 2 2
MIRT541480 ARF3 ADP ribosylation factor 3 2 6
MIRT576737 Wars tryptophanyl-tRNA synthetase 2 2
MIRT610462 SYNPO2L synaptopodin 2 like 2 4
MIRT614189 GGT7 gamma-glutamyltransferase 7 2 2
MIRT626341 PCSK7 proprotein convertase subtilisin/kexin type 7 2 2
MIRT627547 SNIP1 Smad nuclear interacting protein 1 2 2
MIRT628605 TMEM251 transmembrane protein 251 2 2
MIRT630827 YTHDC1 YTH domain containing 1 2 4
MIRT633419 TMEM120B transmembrane protein 120B 2 2
MIRT635354 CSMD2 CUB and Sushi multiple domains 2 2 2
MIRT636418 MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2 2
MIRT637031 SPTLC3 serine palmitoyltransferase long chain base subunit 3 2 2
MIRT638032 TMEM109 transmembrane protein 109 2 2
MIRT642847 ZBTB7C zinc finger and BTB domain containing 7C 2 2
MIRT644389 CD59 CD59 molecule (CD59 blood group) 2 2
MIRT645167 NOL9 nucleolar protein 9 2 2
MIRT645601 MRPS15 mitochondrial ribosomal protein S15 2 2
MIRT649169 IQSEC1 IQ motif and Sec7 domain 1 2 2
MIRT659166 DCTN5 dynactin subunit 5 2 4
MIRT660814 AHCY adenosylhomocysteinase 2 2
MIRT663640 HM13 histocompatibility minor 13 2 2
MIRT663848 TRIM72 tripartite motif containing 72 2 2
MIRT666535 RNF157 ring finger protein 157 2 2
MIRT667885 IP6K1 inositol hexakisphosphate kinase 1 2 2
MIRT671613 C6orf25 megakaryocyte and platelet inhibitory receptor G6b 2 2
MIRT673800 MALL mal, T-cell differentiation protein like 2 2
MIRT676281 ZNF260 zinc finger protein 260 2 2
MIRT687008 RPL35 ribosomal protein L35 2 2
MIRT689090 ACVR1 activin A receptor type 1 2 2
MIRT689259 WDR83OS WD repeat domain 83 opposite strand 2 2
MIRT697458 ZC3H4 zinc finger CCCH-type containing 4 2 2
MIRT699223 SLCO3A1 solute carrier organic anion transporter family member 3A1 2 2
MIRT710222 JMJD4 jumonji domain containing 4 2 2
MIRT710935 ING5 inhibitor of growth family member 5 2 2
MIRT715830 ZNF598 zinc finger protein 598 2 2
MIRT716134 THOC5 THO complex 5 2 2
MIRT717518 HRNR hornerin 2 2
MIRT717918 LRRC15 leucine rich repeat containing 15 2 2
MIRT718307 XPOT exportin for tRNA 2 2
MIRT721350 LIF LIF, interleukin 6 family cytokine 2 2
MIRT724503 MSMO1 methylsterol monooxygenase 1 2 2
MIRT724993 FSTL3 follistatin like 3 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4650 Gemcitabine 60750 NSC613327 approved resistant Low Pancreatic Cancer cell line (SW1990)
hsa-miR-4650 Gemcitabine 60750 NSC613327 approved sensitive High Pancreatic Cancer cell line (SW1990)
hsa-miR-4650-5p Gemcitabine 60750 NSC613327 approved resistant High Pancreatic Cancer cell line (SW1990)
hsa-miR-4650-5p Tripterygium wilfordii Hook F resistant tissue

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