miRTarBase - #MIRT528905


—
pre-miRNA Information
pre-miRNA hsa-mir-4281   
Genomic Coordinates chr5: 176629439 - 176629500
Description Homo sapiens miR-4281 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4281
Sequence 35| GGGUCCCGGGGAGGGGGG |52
Evidence Experimental
Experiments SOLiD
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs921488943 1 dbSNP
rs1040286402 3 dbSNP
rs1375541904 8 dbSNP
rs759166911 12 dbSNP
rs768735686 13 dbSNP
rs746495416 14 dbSNP
rs779751131 18 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol THBS2   
Synonyms TSP2
Description thrombospondin 2
Transcript NM_003247   
Expression
Putative miRNA Targets on THBS2
3'UTR of THBS2
(miRNA target sites are highlighted)		 
>THBS2|NM_003247|3'UTR
   1 ACAAGATTTGCTGCATTTCCGGCAATGCCCTGTGCATGCCATGGTCCCTAGACACCTCAGTTCATTGTGGTCCTTGTGGC
  81 TTCTCTCTCTAGCAGCACCTCCTGTCCCTTGACCTTAACTCTGATGGTTCTTCACCTCCTGCCAGCAACCCCAAACCCAA
 161 GTGCCTTCAGAGGATAAATATCAATGGAACTCAGAGATGAACATCTAACCCACTAGAGGAAACCAGTTTGGTGATATATG
 241 AGACTTTATGTGGAGTGAAAATTGGGCATGCCATTACATTGCTTTTTCTTGTTTGTTTAAAAAGAATGACGTTTACATAT
 321 AAAATGTAATTACTTATTGTATTTATGTGTATATGGAGTTGAAGGGAATACTGTGCATAAGCCATTATGATAAATTAAGC
 401 ATGAAAAATATTGCTGAACTACTTTTGGTGCTTAAAGTTGTCACTATTCTTGAATTAGAGTTGCTCTACAATGACACACA
 481 AATCCCATTAAATAAATTATAAACAAGGGTCAATTCAAATTTGAAGTAATGTTTTAGTAAGGAGAGATTAGAAGACAACA
 561 GGCATAGCAAATGACATAAGCTACCGATTAACTAATCGGAACATGTAAAACAGTTACAAAAATAAACGAACTCTCCTCTT
 641 GTCCTACAATGAAAGCCCTCATGTGCAGTAGAGATGCAGTTTCATCAAAGAACAAACATCCTTGCAAATGGGTGTGACGC
 721 GGTTCCAGATGTGGATTTGGCAAAACCTCATTTAAGTAAAAGGTTAGCAGAGCAAAGTGCGGTGCTTTAGCTGCTGCTTG
 801 TGCCGCTGTGGCGTCGGGGAGGCTCCTGCCTGAGCTTCCTTCCCCAGCTTTGCTGCCTGAGAGGAACCAGAGCAGACGCA
 881 CAGGCCGGAAAAGGCGCATCTAACGCGTATCTAGGCTTTGGTAACTGCGGACAAGTTGCTTTTACCTGATTTGATGATAC
 961 ATTTCATTAAGGTTCCAGTTATAAATATTTTGTTAATATTTATTAAGTGACTATAGAATGCAACTCCATTTACCAGTAAC
1041 TTATTTTAAATATGCCTAGTAACACATATGTAGTATAATTTCTAGAAACAAACATCTAATAAGTATATAATCCTGTGAAA
1121 ATATGAGGCTTGATAATATTAGGTTGTCACGATGAAGCATGCTAGAAGCTGTAACAGAATACATAGAGAATAATGAGGAG
1201 TTTATGATGGAACCTTAAATATATAATGTTGCCAGCGATTTTAGTTCAATATTTGTTACTGTTATCTATCTGCTGTATAT
1281 GGAATTCTTTTAATTCAAACGCTGAAAAGAATCAGCATTTAGTCTTGCCAGGCACACCCAATAATCAGTCATGTGTAATA
1361 TGCACAAGTTTGTTTTTGTTTTTGTTTTTTTTGTTGGTTGGTTTGTTTTTTTGCTTTAAGTTGCATGATCTTTCTGCAGG
1441 AAATAGTCACTCATCCCACTCCACATAAGGGGTTTAGTAAGAGAAGTCTGTCTGTCTGATGATGGATAGGGGGCAAATCT
1521 TTTTCCCCTTTCTGTTAATAGTCATCACATTTCTATGCCAAACAGGAACAATCCATAACTTTAGTCTTAATGTACACATT
1601 GCATTTTGATAAAATTAATTTTGTTGTTTCCTTTGAGGTTGATCGTTGTGTTGTTGTTTTGCTGCACTTTTTACTTTTTT
1681 GCGTGTGGAGCTGTATTCCCGAGACCAACGAAGCGTTGGGATACTTCATTAAATGTAGCGACTGTCAACAGCGTGCAGGT
1761 TTTCTGTTTCTGTGTTGTGGGGTCAACCGTACAATGGTGTGGGAGTGACGATGATGTGAATATTTAGAATGTACCATATT
1841 TTTTGTAAATTATTTATGTTTTTCTAAACAAATTTATCGTATAGGTTGATGAAACGTCATGTGTTTTGCCAAAGACTGTA
1921 AATATTTATTTATGTGTTCACATGGTCAAAATTTCACCACTGAAACCCTGCACTTAGCTAGAACCTCATTTTTAAAGATT
2001 AACAACAGGAAATAAATTGTAAAAAAGGTTTTCTATACATGAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' ggggggAGGGGCCCUGGg 5'
                |:|||| |||| 
Target 5' gctgtaTTCCCGAGACCa 3'
 1690 - 1707 124.00 -17.80
2 
miRNA  3' ggGGGGA-GGGGCCCUGGg 5'
            |:||| :|||  |||| 
Target 5' acCTCCTGTCCCTTGACCt 3'
 97 - 115 100.00 -23.90
3 
miRNA  3' gggggGAGGGGCCCUGgg 5'
               ||  :||| ||  
Target 5' attaaCTAATCGGAACat 3'
 587 - 604 93.00 -9.20
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31560221 7 COSMIC
COSN30135015 8 COSMIC
COSN26998503 35 COSMIC
COSN28582611 48 COSMIC
COSN31532368 59 COSMIC
COSN511123 59 COSMIC
COSN30191741 69 COSMIC
COSN31491657 70 COSMIC
COSN167942 77 COSMIC
COSN30489829 97 COSMIC
COSN30489673 98 COSMIC
COSN31523512 130 COSMIC
COSN30117814 141 COSMIC
COSN30516977 141 COSMIC
COSN31575551 170 COSMIC
COSN14715533 191 COSMIC
COSN30121954 222 COSMIC
COSN31662825 227 COSMIC
COSN8796047 300 COSMIC
COSN15662132 310 COSMIC
COSN32056948 311 COSMIC
COSN30540628 428 COSMIC
COSN2153844 638 COSMIC
COSN14846277 718 COSMIC
COSN31962724 720 COSMIC
COSN14743400 812 COSMIC
COSN17127736 815 COSMIC
COSN32058716 815 COSMIC
COSN17076504 816 COSMIC
COSN5626707 1037 COSMIC
COSN29993139 1063 COSMIC
COSN20103667 1217 COSMIC
COSN153214 1237 COSMIC
COSN20103662 1308 COSMIC
COSN32061249 1401 COSMIC
COSN20550711 1404 COSMIC
COSN14700170 1494 COSMIC
COSN14739222 1586 COSMIC
COSN20103660 1649 COSMIC
COSN15072031 1710 COSMIC
COSN14766631 1805 COSMIC
COSN31544720 1878 COSMIC
COSN24301703 1959 COSMIC
COSN31596160 1976 COSMIC
COSN31551429 2020 COSMIC
rs1040 1570 GWAS
rs3253 1805 GWAS
rs3252 1820 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1215621645 2 dbSNP
rs201197808 5 dbSNP
rs778445351 5 dbSNP
rs1357226464 8 dbSNP
rs1424432861 15 dbSNP
rs764178250 16 dbSNP
rs1225941106 18 dbSNP
rs763405590 20 dbSNP
rs182421013 21 dbSNP
rs765462074 26 dbSNP
rs73043837 28 dbSNP
rs776141152 30 dbSNP
rs371770967 34 dbSNP
rs760241678 36 dbSNP
rs772802073 37 dbSNP
rs771738977 38 dbSNP
rs1391952237 42 dbSNP
rs1301829818 45 dbSNP
rs1168927796 46 dbSNP
rs1379060890 48 dbSNP
rs1397215211 56 dbSNP
rs1418644031 66 dbSNP
rs1019992175 68 dbSNP
rs1316557700 76 dbSNP
rs536934623 76 dbSNP
rs12435 77 dbSNP
rs1259128979 81 dbSNP
rs1320370538 82 dbSNP
rs1262075770 83 dbSNP
rs1208324250 91 dbSNP
rs1237072385 91 dbSNP
rs376986145 92 dbSNP
rs1183642707 94 dbSNP
rs984111826 103 dbSNP
rs190347402 120 dbSNP
rs1477446915 124 dbSNP
rs952698920 126 dbSNP
rs1027559983 129 dbSNP
rs971951203 131 dbSNP
rs1359354600 135 dbSNP
rs71668022 141 dbSNP
rs1001019241 172 dbSNP
rs1295801431 175 dbSNP
rs577909429 178 dbSNP
rs1399940840 180 dbSNP
rs1217813426 181 dbSNP
rs1342800089 181 dbSNP
rs1466817198 182 dbSNP
rs1278236268 184 dbSNP
rs1312993038 189 dbSNP
rs8089 191 dbSNP
rs1283990661 193 dbSNP
rs1009696818 196 dbSNP
rs532292320 203 dbSNP
rs779685492 219 dbSNP
rs1194339742 231 dbSNP
rs894243592 242 dbSNP
rs565455667 255 dbSNP
rs1190377118 262 dbSNP
rs1425506935 265 dbSNP
rs1056531754 274 dbSNP
rs545567300 276 dbSNP
rs1156389673 277 dbSNP
rs1359384883 278 dbSNP
rs1419723515 285 dbSNP
rs866894604 286 dbSNP
rs904187065 299 dbSNP
rs1041365981 310 dbSNP
rs946289739 311 dbSNP
rs1274615366 315 dbSNP
rs1372386929 334 dbSNP
rs1368676973 336 dbSNP
rs1221158269 337 dbSNP
rs1303056748 337 dbSNP
rs901394742 339 dbSNP
rs1439158506 341 dbSNP
rs550430283 342 dbSNP
rs937970865 351 dbSNP
rs1387404967 356 dbSNP
rs1289733529 357 dbSNP
rs531995536 358 dbSNP
rs1217400231 359 dbSNP
rs1288119797 360 dbSNP
rs750276099 365 dbSNP
rs1449786091 367 dbSNP
rs1048942725 376 dbSNP
rs1453123476 382 dbSNP
rs1247076422 386 dbSNP
rs1489318706 388 dbSNP
rs1343554932 392 dbSNP
rs1379282763 395 dbSNP
rs1439818153 397 dbSNP
rs1159929090 399 dbSNP
rs1175639872 399 dbSNP
rs1410879551 405 dbSNP
rs561443774 406 dbSNP
rs1041237159 410 dbSNP
rs1455497499 415 dbSNP
rs1395628693 417 dbSNP
rs942846806 418 dbSNP
rs1192703287 429 dbSNP
rs930491015 431 dbSNP
rs1376395997 434 dbSNP
rs1241041588 444 dbSNP
rs1281334906 444 dbSNP
rs1354261339 446 dbSNP
rs919055883 447 dbSNP
rs1431297318 462 dbSNP
rs542958792 465 dbSNP
rs12208495 466 dbSNP
rs1205397405 469 dbSNP
rs1485357321 476 dbSNP
rs972842615 478 dbSNP
rs1290447820 482 dbSNP
rs961756468 486 dbSNP
rs10280 487 dbSNP
rs1132755 488 dbSNP
rs66847991 488 dbSNP
rs386708878 489 dbSNP
rs879522515 489 dbSNP
rs1180061314 494 dbSNP
rs1235247761 498 dbSNP
rs1472153886 500 dbSNP
rs139455322 505 dbSNP
rs1415127487 506 dbSNP
rs1463378935 507 dbSNP
rs1168970704 511 dbSNP
rs577752124 516 dbSNP
rs1280318681 526 dbSNP
rs918588908 531 dbSNP
rs1328615059 532 dbSNP
rs762191244 535 dbSNP
rs1447363947 536 dbSNP
rs565995027 538 dbSNP
rs972673523 541 dbSNP
rs1257205418 543 dbSNP
rs1001090919 545 dbSNP
rs1441386334 546 dbSNP
rs1187596173 549 dbSNP
rs1024618906 558 dbSNP
rs113919708 559 dbSNP
rs1314766786 573 dbSNP
rs1192053103 576 dbSNP
rs1423398309 576 dbSNP
rs1466425708 579 dbSNP
rs1169921234 586 dbSNP
rs1400298309 593 dbSNP
rs1334910234 596 dbSNP
rs1435423701 596 dbSNP
rs968216621 597 dbSNP
rs1398075086 598 dbSNP
rs1021502409 604 dbSNP
rs1172986813 610 dbSNP
rs1464328755 613 dbSNP
rs1009359581 616 dbSNP
rs1229310447 616 dbSNP
rs1281857720 617 dbSNP
rs185473673 617 dbSNP
rs1215118382 618 dbSNP
rs1263079992 627 dbSNP
rs576240703 628 dbSNP
rs999949151 638 dbSNP
rs1376196047 643 dbSNP
rs904240789 647 dbSNP
rs1173313074 649 dbSNP
rs191995205 656 dbSNP
rs1010295227 659 dbSNP
rs536590357 662 dbSNP
rs1260595783 663 dbSNP
rs1189436852 666 dbSNP
rs146272757 668 dbSNP
rs116741283 669 dbSNP
rs1199289989 671 dbSNP
rs1007090924 673 dbSNP
rs1342129132 675 dbSNP
rs1330237208 677 dbSNP
rs1233523482 692 dbSNP
rs1305114660 693 dbSNP
rs188677770 695 dbSNP
rs1238758158 699 dbSNP
rs538721622 705 dbSNP
rs1048503193 707 dbSNP
rs897699801 710 dbSNP
rs14219 718 dbSNP
rs1037011621 720 dbSNP
rs1194526826 721 dbSNP
rs550366892 723 dbSNP
rs940147422 726 dbSNP
rs1397094467 729 dbSNP
rs1437946818 735 dbSNP
rs949395046 737 dbSNP
rs1295420416 740 dbSNP
rs1345167661 741 dbSNP
rs370945450 746 dbSNP
rs76923194 748 dbSNP
rs993151707 760 dbSNP
rs958610375 761 dbSNP
rs1327554603 779 dbSNP
rs1311172849 781 dbSNP
rs986881610 783 dbSNP
rs537625161 791 dbSNP
rs927117746 804 dbSNP
rs114924628 805 dbSNP
rs9505892 806 dbSNP
rs386708877 807 dbSNP
rs1241849362 810 dbSNP
rs1132757 812 dbSNP
rs1421000697 813 dbSNP
rs968287420 815 dbSNP
rs1021158195 816 dbSNP
rs143381501 817 dbSNP
rs1178194548 818 dbSNP
rs545018994 824 dbSNP
rs1019906646 833 dbSNP
rs760969313 838 dbSNP
rs1035195727 845 dbSNP
rs1256148823 852 dbSNP
rs1367791647 855 dbSNP
rs1184812103 868 dbSNP
rs533225472 877 dbSNP
rs184070674 878 dbSNP
rs9393157 886 dbSNP
rs772540472 887 dbSNP
rs565500985 891 dbSNP
rs995610000 893 dbSNP
rs576148849 895 dbSNP
rs1311258131 896 dbSNP
rs554795485 899 dbSNP
rs1275247560 904 dbSNP
rs994746039 905 dbSNP
rs1198283954 906 dbSNP
rs774950340 907 dbSNP
rs1334469747 914 dbSNP
rs1282441653 916 dbSNP
rs1180191982 926 dbSNP
rs1255461272 927 dbSNP
rs371966970 928 dbSNP
rs1241276410 929 dbSNP
rs1421252604 938 dbSNP
rs1464866292 943 dbSNP
rs1170767563 947 dbSNP
rs1337453690 952 dbSNP
rs1355888152 956 dbSNP
rs1464162828 959 dbSNP
rs1329523980 960 dbSNP
rs542533889 962 dbSNP
rs1390580060 963 dbSNP
rs1415937659 967 dbSNP
rs897722197 968 dbSNP
rs917912773 969 dbSNP
rs1327708482 973 dbSNP
rs1218375779 977 dbSNP
rs1296646999 977 dbSNP
rs1055099281 981 dbSNP
rs1208217303 982 dbSNP
rs1255494593 995 dbSNP
rs1461598736 998 dbSNP
rs1486017693 999 dbSNP
rs1212966296 1001 dbSNP
rs1416737908 1005 dbSNP
rs1036223747 1007 dbSNP
rs927169959 1007 dbSNP
rs1160881839 1009 dbSNP
rs1421280273 1009 dbSNP
rs944557404 1009 dbSNP
rs572404610 1014 dbSNP
rs1174832392 1023 dbSNP
rs978614216 1031 dbSNP
rs191497961 1035 dbSNP
rs761859512 1043 dbSNP
rs1051625129 1066 dbSNP
rs538657444 1067 dbSNP
rs968525380 1069 dbSNP
rs913018015 1072 dbSNP
rs1289836681 1079 dbSNP
rs988966610 1096 dbSNP
rs932684441 1099 dbSNP
rs1255229429 1101 dbSNP
rs1302936675 1103 dbSNP
rs73238283 1107 dbSNP
rs979421184 1108 dbSNP
rs1019708117 1111 dbSNP
rs946982160 1113 dbSNP
rs148654134 1122 dbSNP
rs1487913547 1122 dbSNP
rs954313893 1133 dbSNP
rs1288067028 1135 dbSNP
rs200216944 1139 dbSNP
rs1190293155 1142 dbSNP
rs151019608 1142 dbSNP
rs199910573 1143 dbSNP
rs74763679 1144 dbSNP
rs1280034099 1146 dbSNP
rs961168385 1150 dbSNP
rs1035155319 1151 dbSNP
rs1379095253 1153 dbSNP
rs1015722974 1160 dbSNP
rs61324355 1162 dbSNP
rs769502453 1163 dbSNP
rs745491202 1165 dbSNP
rs1434738959 1166 dbSNP
rs549589288 1177 dbSNP
rs527948549 1179 dbSNP
rs781016288 1180 dbSNP
rs775656736 1184 dbSNP
rs994443262 1187 dbSNP
rs1307195191 1195 dbSNP
rs1401918247 1195 dbSNP
rs1352989349 1197 dbSNP
rs566848142 1205 dbSNP
rs937975225 1213 dbSNP
rs1286196214 1215 dbSNP
rs35848483 1220 dbSNP
rs397802294 1220 dbSNP
rs961714721 1223 dbSNP
rs1253307443 1226 dbSNP
rs1469548761 1236 dbSNP
rs73043835 1237 dbSNP
rs1237065560 1244 dbSNP
rs1470156193 1251 dbSNP
rs1159703578 1255 dbSNP
rs1410764032 1258 dbSNP
rs1404017518 1261 dbSNP
rs1438319537 1265 dbSNP
rs1397434061 1267 dbSNP
rs1194646850 1270 dbSNP
rs947240655 1272 dbSNP
rs1008783504 1278 dbSNP
rs1463214759 1280 dbSNP
rs1329508455 1283 dbSNP
rs751272350 1287 dbSNP
rs1050248794 1288 dbSNP
rs1281251594 1290 dbSNP
rs1442986733 1290 dbSNP
rs1245176306 1292 dbSNP
rs1376872841 1292 dbSNP
rs996968571 1300 dbSNP
rs200744135 1308 dbSNP
rs71861019 1308 dbSNP
rs56413144 1309 dbSNP
rs899905766 1309 dbSNP
rs1195647949 1312 dbSNP
rs1447833826 1313 dbSNP
rs533165388 1332 dbSNP
rs562584898 1337 dbSNP
rs182539309 1342 dbSNP
rs1257004958 1348 dbSNP
rs1437949348 1353 dbSNP
rs1283593486 1355 dbSNP
rs1214565215 1361 dbSNP
rs1351336242 1362 dbSNP
rs1472103172 1370 dbSNP
rs529918689 1374 dbSNP
rs913075273 1374 dbSNP
rs1282470979 1377 dbSNP
rs1419066080 1378 dbSNP
rs1234732806 1382 dbSNP
rs1168858103 1383 dbSNP
rs1395999999 1384 dbSNP
rs529415979 1384 dbSNP
rs1410664509 1385 dbSNP
rs988630242 1388 dbSNP
rs1357436849 1390 dbSNP
rs200734981 1393 dbSNP
rs943800009 1393 dbSNP
rs9505928 1396 dbSNP
rs1216539243 1397 dbSNP
rs1357191258 1397 dbSNP
rs1269301292 1402 dbSNP
rs912291326 1403 dbSNP
rs1485033332 1404 dbSNP
rs3209352 1404 dbSNP
rs554207996 1404 dbSNP
rs953702022 1406 dbSNP
rs398049010 1409 dbSNP
rs55724365 1409 dbSNP
rs1027228520 1410 dbSNP
rs1191947669 1413 dbSNP
rs1372810609 1413 dbSNP
rs1326669784 1419 dbSNP
rs974293446 1421 dbSNP
rs1417396462 1424 dbSNP
rs1043773506 1431 dbSNP
rs1377781036 1433 dbSNP
rs1169831531 1437 dbSNP
rs961573414 1442 dbSNP
rs752375978 1446 dbSNP
rs1313454480 1449 dbSNP
rs1377195628 1450 dbSNP
rs1397978958 1456 dbSNP
rs1434454834 1459 dbSNP
rs1326733492 1467 dbSNP
rs946719061 1468 dbSNP
rs1272667492 1470 dbSNP
rs1346587634 1471 dbSNP
rs913869604 1474 dbSNP
rs1281747391 1475 dbSNP
rs1003 1480 dbSNP
rs114403822 1484 dbSNP
rs1475833201 1485 dbSNP
rs1041 1490 dbSNP
rs1132782 1494 dbSNP
rs1191596908 1499 dbSNP
rs1261513591 1504 dbSNP
rs572342308 1505 dbSNP
rs903851809 1508 dbSNP
rs1211560515 1512 dbSNP
rs554109284 1514 dbSNP
rs947296486 1518 dbSNP
rs544978197 1522 dbSNP
rs1053382795 1525 dbSNP
rs1417790148 1525 dbSNP
rs943869021 1529 dbSNP
rs1321221499 1537 dbSNP
rs1383682939 1537 dbSNP
rs912330148 1539 dbSNP
rs1441077012 1540 dbSNP
rs1267860116 1541 dbSNP
rs1304998174 1541 dbSNP
rs969132008 1550 dbSNP
rs1397558316 1563 dbSNP
rs143959285 1566 dbSNP
rs973099678 1569 dbSNP
rs1040 1570 dbSNP
rs961622515 1572 dbSNP
rs779001664 1575 dbSNP
rs1172909909 1584 dbSNP
rs1042 1586 dbSNP
rs960895958 1588 dbSNP
rs1254993588 1599 dbSNP
rs1417342080 1621 dbSNP
rs1181058264 1626 dbSNP
rs1034217316 1635 dbSNP
rs1168862334 1638 dbSNP
rs954641754 1639 dbSNP
rs573698737 1643 dbSNP
rs1476210849 1644 dbSNP
rs1028860856 1645 dbSNP
rs1161227306 1646 dbSNP
rs559932298 1648 dbSNP
rs555656149 1649 dbSNP
rs1187325241 1651 dbSNP
rs1482847866 1652 dbSNP
rs56285391 1652 dbSNP
rs968092191 1653 dbSNP
rs1390284739 1654 dbSNP
rs200915200 1656 dbSNP
rs1241733888 1659 dbSNP
rs1307000094 1659 dbSNP
rs148174605 1659 dbSNP
rs35009372 1659 dbSNP
rs904327576 1664 dbSNP
rs574115858 1668 dbSNP
rs891732134 1681 dbSNP
rs1214574832 1682 dbSNP
rs149476079 1683 dbSNP
rs1008512788 1687 dbSNP
rs1256990591 1696 dbSNP
rs1010951644 1700 dbSNP
rs1420818599 1701 dbSNP
rs1049511768 1702 dbSNP
rs1416927011 1704 dbSNP
rs1293308474 1709 dbSNP
rs1227250509 1710 dbSNP
rs1166695288 1715 dbSNP
rs1377621523 1716 dbSNP
rs1461100661 1718 dbSNP
rs560804021 1720 dbSNP
rs932415819 1724 dbSNP
rs1393675216 1736 dbSNP
rs919653011 1738 dbSNP
rs9310 1739 dbSNP
rs1234248216 1740 dbSNP
rs1463155868 1752 dbSNP
rs188701483 1753 dbSNP
rs1251998711 1757 dbSNP
rs1481631144 1765 dbSNP
rs1208700502 1766 dbSNP
rs1256681082 1778 dbSNP
rs928200476 1781 dbSNP
rs767591813 1787 dbSNP
rs1164165395 1788 dbSNP
rs948238066 1789 dbSNP
rs1417059028 1793 dbSNP
rs1427564084 1804 dbSNP
rs3253 1805 dbSNP
rs183161171 1807 dbSNP
rs992419214 1809 dbSNP
rs1440269992 1810 dbSNP
rs1375367838 1812 dbSNP
rs961204884 1818 dbSNP
rs3252 1820 dbSNP
rs961820860 1827 dbSNP
rs980909410 1833 dbSNP
rs907567320 1839 dbSNP
rs1191783535 1840 dbSNP
rs1469481384 1848 dbSNP
rs1296536209 1852 dbSNP
rs779351794 1857 dbSNP
rs1273504002 1861 dbSNP
rs1309377358 1876 dbSNP
rs1232178552 1878 dbSNP
rs137970006 1879 dbSNP
rs1348527109 1882 dbSNP
rs562233108 1883 dbSNP
rs1212855807 1886 dbSNP
rs1220174271 1896 dbSNP
rs1485392257 1898 dbSNP
rs1186791302 1899 dbSNP
rs954811514 1903 dbSNP
rs1028934329 1908 dbSNP
rs1319453801 1908 dbSNP
rs1172460322 1909 dbSNP
rs548855380 1911 dbSNP
rs1309749593 1918 dbSNP
rs1435886272 1920 dbSNP
rs974622546 1924 dbSNP
rs1343854826 1929 dbSNP
rs1376844267 1934 dbSNP
rs769262210 1934 dbSNP
rs1022371297 1941 dbSNP
rs1289741099 1944 dbSNP
rs1367608761 1952 dbSNP
rs1438911854 1961 dbSNP
rs1302776250 1964 dbSNP
rs968541990 1968 dbSNP
rs1021465351 1970 dbSNP
rs527489275 1971 dbSNP
rs371991523 1972 dbSNP
rs1395476214 1976 dbSNP
rs956724812 1985 dbSNP
rs1293209182 1986 dbSNP
rs1216228995 1994 dbSNP
rs1031441694 2003 dbSNP
rs1262185198 2006 dbSNP
rs1456424877 2016 dbSNP
rs1346994638 2021 dbSNP
rs1192542765 2034 dbSNP
rs1003563664 2036 dbSNP
rs73043834 2038 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions hESCs (WA-09)
Disease 7058.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in SRR359787. RNA binding protein: AGO2. Condition:4-thiouridine ...

- Lipchina I; Elkabetz Y; Hafner M; Sheridan et al., 2011, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' ggggggaggggCCCUGGg 5'
                     |||||| 
Target 5' --------uugGGGACCa 3'
 		1 - 10
Article - Lipchina I; Elkabetz Y; Hafner M; Sheridan et al.
- Genes & development, 2011
MicroRNAs are important regulators in many cellular processes, including stem cell self-renewal. Recent studies demonstrated their function as pluripotency factors with the capacity for somatic cell reprogramming. However, their role in human embryonic stem (ES) cells (hESCs) remains poorly understood, partially due to the lack of genome-wide strategies to identify their targets. Here, we performed comprehensive microRNA profiling in hESCs and in purified neural and mesenchymal derivatives. Using a combination of AGO cross-linking and microRNA perturbation experiments, together with computational prediction, we identified the targets of the miR-302/367 cluster, the most abundant microRNAs in hESCs. Functional studies identified novel roles of miR-302/367 in maintaining pluripotency and regulating hESC differentiation. We show that in addition to its role in TGF-beta signaling, miR-302/367 promotes bone morphogenetic protein (BMP) signaling by targeting BMP inhibitors TOB2, DAZAP2, and SLAIN1. This study broadens our understanding of microRNA function in hESCs and is a valuable resource for future studies in this area.
LinkOut: [PMID: 22012620]
CLIP-seq Support 1 for dataset SRR359787
Method / RBP PAR-CLIP / AGO2
Cell line / Condition hESCs (WA-09) / 4-thiouridine, RNase T1
Location of target site ENST00000366787.3 | 3UTR | UUGGGGACCACGUGGGCAUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22012620 / SRX103431
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
29 hsa-miR-4281 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT218864 CDKN1A cyclin dependent kinase inhibitor 1A 2 4
MIRT248841 SESN2 sestrin 2 2 2
MIRT452803 PACS2 phosphofurin acidic cluster sorting protein 2 2 2
MIRT462825 BCL3 B-cell CLL/lymphoma 3 2 2
MIRT467812 SLC29A2 solute carrier family 29 member 2 2 2
MIRT477707 EFHD2 EF-hand domain family member D2 2 2
MIRT490047 PRRT2 proline rich transmembrane protein 2 2 2
MIRT491813 ZBTB7B zinc finger and BTB domain containing 7B 2 2
MIRT528905 THBS2 thrombospondin 2 2 2
MIRT534124 SNX33 sorting nexin 33 2 2
MIRT550881 IBA57 IBA57 homolog, iron-sulfur cluster assembly 2 2
MIRT551263 PSMG1 proteasome assembly chaperone 1 2 2
MIRT551984 UGT2B10 UDP glucuronosyltransferase family 2 member B10 2 2
MIRT608916 NCDN neurochondrin 2 6
MIRT637226 TMEM59 transmembrane protein 59 2 2
MIRT644445 ALDOC aldolase, fructose-bisphosphate C 2 2
MIRT657162 IP6K1 inositol hexakisphosphate kinase 1 2 2
MIRT658754 ELAVL3 ELAV like RNA binding protein 3 2 2
MIRT668304 FOSL2 FOS like 2, AP-1 transcription factor subunit 2 2
MIRT687548 MLEC malectin 2 2
MIRT690860 PLEKHG2 pleckstrin homology and RhoGEF domain containing G2 2 2
MIRT697063 PSMC4 proteasome 26S subunit, ATPase 4 2 2
MIRT700860 PER2 period circadian clock 2 2 2
MIRT705073 C4orf29 abhydrolase domain containing 18 2 2
MIRT713930 PIGR polymeric immunoglobulin receptor 2 2
MIRT715904 MFRP membrane frizzled-related protein 2 2
MIRT716060 SFTPB surfactant protein B 2 2
MIRT716729 APOL6 apolipoprotein L6 2 2
MIRT723382 NFAM1 NFAT activating protein with ITAM motif 1 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miR-4281 Ginsenoside Rh2 NULL 119307 Microarray NSCLC cell line A549 23152132 2013 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4281 Cisplatin 5460033 NSC119875 approved resistant High Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-4281 Platinum 23939 sensitive High Ovarian Cancer tissue
hsa-miR-4281 Vemurafenib 42611257 NSC761431 approved sensitive High Melanoma cell line (PLX4032, LM16)
hsa-miR-4281 Cisplatin 5460033 NSC119875 approved resistant High Pancreatic Cancer cell line (BxPC-3)
hsa-miR-4281 Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (A375)
hsa-miR-4281 Paclitaxel 36314 NSC125973 approved resistant High Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-4281 Paclitaxel 36314 NSC125973 approved resistant High Non-Small Cell Lung Cancer cell line (H460)
hsa-mir-4281 Dabrafenib 44462760 NSC764134 approved resistant cell line (A375)
hsa-mir-4281 Cisplatin 5460033 NSC119875 approved sensitive cell line
hsa-mir-4281 Doxorubicin 31703 NSC123127 approved resistant cell line (BAS)
hsa-mir-4281 Doxorubicin 31703 NSC123127 approved resistant cell line (HS578T)
hsa-mir-4281 Paclitaxel 36314 NSC125973 approved resistant cell line (W1)
hsa-mir-4281 Androstenedione+Letrozole sensitive cell line (MCF-7)
hsa-mir-4281 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-miR-4281 Temozolomide 5394 NSC362856 approved resistant cell line (U251)
hsa-miR-4281 Tamoxifen+Fulvestrant resistant cell line (LCC9)
hsa-miR-4281 Cisplatin 5460033 NSC119875 approved resistant cell line (CIS)
hsa-miR-4281 Cisplatin 5460033 NSC119875 approved resistant cell line (CP20)
hsa-miR-4281 Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-4281 Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-4281 Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM16)
hsa-miR-4281 Neoadjuvant chemotherapy sensitive tissue (breast cancer)
hsa-miR-4281 Cisplatin 5460033 NSC119875 approved sensitive cell line (TOV-112D)
hsa-miR-4281 Cisplatin 5460033 NSC119875 approved resistant cell line (OVSAHO)

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