miRTarBase - #MIRT529081


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pre-miRNA Information
pre-miRNA hsa-mir-6751   
Genomic Coordinates chr11: 65129916 - 65129978
Description Homo sapiens miR-6751 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6751-3p
Sequence 43| ACUGAGCCUCUCUCUCUCCAG |63
Evidence Experimental
Experiments Meta-analysis
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSM6795708 8 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs749989972 2 dbSNP
rs1266150108 3 dbSNP
rs1488089412 6 dbSNP
rs1259846893 8 dbSNP
rs3802937 10 dbSNP
rs371083440 12 dbSNP
rs1264909843 13 dbSNP
rs751042478 14 dbSNP
rs757551063 19 dbSNP
Putative Targets

Gene Information
Gene Symbol PATE2   
Synonyms C11orf38, PATE-M, UNQ3112
Description prostate and testis expressed 2
Transcript NM_212555   
Expression
Putative miRNA Targets on PATE2
3'UTR of PATE2
(miRNA target sites are highlighted)		 
>PATE2|NM_212555|3'UTR
   1 TTCTACGTCTCTCCTGGATTTTGGGTTCTTTTTCAACCACTACGCTCTTTTTCTCTTCCCTGAACCTGAATTTTGCTCTC
  81 CTCTTCTATGCATTGGTAGAGAGTGAGAAAGCCAGCTCATAGTGAAAAGACAAGCAGGCATAAGGAGACGCAGTGTGGAC
 161 AGCGGAGCCTATTGATGATGGAGCACTAGACTCACTCTTTGCACATCCCTGTCGCTAACAGGTGGGAGGGGTTTTGCTCT
 241 CCTTACGTGATACTGCCATGAATAAGCTCAGACTTGGTCATTTATTATCTCCTGTATGAAAATGTGAACACTTGGGCCAT
 321 AATAATCTCCAATTTGTACTGAGAATTCTGTGACTATCCTCTATCCTCATCTACACACACACTCCTCTCCGTTGGAATTC
 401 TCTTTGGATTAGCCCTGACACTTTCTGGCACTGTCCTTTTCTGCCCGTGGGTTCTGGAGAGGGCTAACCCCAGCTTCCCA
 481 GTGTGTTGGCAGCATGGGCCAAGTCTTTCTCTGATAGAGCTCTTGGGGGAACCTCAGGGCAGAAAAAAAAAAACTGAACA
 561 GACATAGGGATGAGCATCAAAGAAAACTTCAGGGGGCATTTCAACTGGTAAAAACTAAGATCTGAGAAATAACTTGCTGT
 641 GGGTGGAATTGGCTTGAATTATCATTGCCCTGGCTGGCCAGGCAGCCTTGGGCACATGGTTGAACTAGGTGATTGGATTG
 721 GGAACAGAGTGTTTTTTTAAGGATGGCTAGTCAGGTTCTTCTCATGGGACTGAGCAAACAAAATGCTGATAATGTGGCAG
 801 GTGGTGTAGTAGTTGAAGATAATAGGATGTAAATAGATACCATGAGGTAGTGTTCAAGTAACAGAGTGCCCTGTGTAAGA
 881 GGAAGTTATGAGTTTGCAGAAAGTGTGAGAAAGGTAGCATATATGGGTAACAGTGGTGGGAAGAGAAGAAGGAAGACACA
 961 GAAACAGATAGGAAGAGAAACTGAGTAGCATTGATGTTGGAGCACACCTGTGGCCAAGGTGGCACATTTTCCTTGGATAC
1041 ACACTAACCCTGGTGTTTCTGTCCTTATAAGGCTGACTGCACCCTAGATGACGGGTTGATGGGTGCAGCAAACCACCATG
1121 GCACATGTATACCTATGTAACAAACCTGCATGCTGCACTTTCTTTCATGTATCCCAGAACTTAAAGTAAAATAAAAAAAT
1201 AAATAAATAAATAAAGGCCAGAAAAATTGGCCAAAAAATCTGAATAGAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' gaccucucucucucCGAGUCa 5'
                        |||||| 
Target 5' actgccatgaataaGCTCAGa 3'
 252 - 272 120.00 -9.80
2 
miRNA  3' gacCUCUCUCUCU-----CCGAGUca 5'
             ||||| ||||      |||||  
Target 5' gtaGAGAGTGAGAAAGCCAGCTCAta 3'
 96 - 121 114.00 -15.34
3 
miRNA  3' gacCUCUCUC-----UCUCC---GAGUCa 5'
             || ||||     :|:||   ||||| 
Target 5' tctGATAGAGCTCTTGGGGGAACCTCAGg 3'
 510 - 538 110.00 -15.40
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN5853755 6 COSMIC
COSN6990810 7 COSMIC
COSN30179223 11 COSMIC
COSN30481969 13 COSMIC
COSN30145990 34 COSMIC
COSN509905 43 COSMIC
COSN26574492 44 COSMIC
COSN26987985 44 COSMIC
COSN26572975 49 COSMIC
COSN30186490 55 COSMIC
COSN30627407 69 COSMIC
COSN18735833 71 COSMIC
COSN30160874 71 COSMIC
COSN31496821 121 COSMIC
COSN30167131 134 COSMIC
COSN19698559 156 COSMIC
COSN20108966 543 COSMIC
COSN8736266 670 COSMIC
COSN21964120 1106 COSMIC
COSN8215343 1196 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs201863710 6 dbSNP
rs369378532 7 dbSNP
rs1239697962 8 dbSNP
rs1353986983 9 dbSNP
rs1334900487 11 dbSNP
rs775841392 14 dbSNP
rs772298341 23 dbSNP
rs759700450 25 dbSNP
rs1337709989 30 dbSNP
rs889229022 32 dbSNP
rs1286978506 37 dbSNP
rs1318014669 39 dbSNP
rs1353101741 39 dbSNP
rs1214463580 41 dbSNP
rs375017722 43 dbSNP
rs770957125 44 dbSNP
rs748102381 48 dbSNP
rs781216053 51 dbSNP
rs902920643 60 dbSNP
rs745477788 63 dbSNP
rs1418564004 71 dbSNP
rs764572866 78 dbSNP
rs1403704659 81 dbSNP
rs1036538173 88 dbSNP
rs1269679786 89 dbSNP
rs553418895 93 dbSNP
rs917410903 98 dbSNP
rs890376106 99 dbSNP
rs1328695529 101 dbSNP
rs1050271776 103 dbSNP
rs1338531350 104 dbSNP
rs1448653501 105 dbSNP
rs192343366 113 dbSNP
rs1376364793 118 dbSNP
rs567639118 127 dbSNP
rs142110610 129 dbSNP
rs926344136 138 dbSNP
rs899143090 149 dbSNP
rs75339386 150 dbSNP
rs548597 156 dbSNP
rs187170807 157 dbSNP
rs1179580516 163 dbSNP
rs1020636944 164 dbSNP
rs907948469 167 dbSNP
rs1176390208 171 dbSNP
rs1378899847 177 dbSNP
rs528277990 183 dbSNP
rs35787733 189 dbSNP
rs1046603303 191 dbSNP
rs988055246 200 dbSNP
rs1171945067 202 dbSNP
rs1417031384 204 dbSNP
rs965987196 207 dbSNP
rs1185415411 213 dbSNP
rs760077644 214 dbSNP
rs559317091 222 dbSNP
rs1243742102 227 dbSNP
rs774911870 230 dbSNP
rs545541938 231 dbSNP
rs1399275077 238 dbSNP
rs916845490 241 dbSNP
rs1018776912 246 dbSNP
rs1467827212 247 dbSNP
rs549040605 255 dbSNP
rs958512678 283 dbSNP
rs925672073 289 dbSNP
rs1456695042 295 dbSNP
rs529000807 304 dbSNP
rs562909124 310 dbSNP
rs1451704854 318 dbSNP
rs888972917 323 dbSNP
rs1375417957 326 dbSNP
rs1478802125 332 dbSNP
rs1028124663 333 dbSNP
rs1305981812 334 dbSNP
rs994938427 340 dbSNP
rs774365383 342 dbSNP
rs1422723523 346 dbSNP
rs967195739 349 dbSNP
rs897779749 350 dbSNP
rs1036358656 363 dbSNP
rs771443201 369 dbSNP
rs886770490 370 dbSNP
rs771014967 380 dbSNP
rs1440855538 382 dbSNP
rs1055869073 384 dbSNP
rs543017653 390 dbSNP
rs926153783 391 dbSNP
rs1247384200 392 dbSNP
rs749591360 412 dbSNP
rs768135022 414 dbSNP
rs1445100427 415 dbSNP
rs1392085137 421 dbSNP
rs1028886214 424 dbSNP
rs979553549 436 dbSNP
rs946528060 446 dbSNP
rs749561127 447 dbSNP
rs987834778 448 dbSNP
rs777922585 450 dbSNP
rs1476721838 451 dbSNP
rs899069112 452 dbSNP
rs1037746012 456 dbSNP
rs1457653005 457 dbSNP
rs532392612 465 dbSNP
rs1161647252 466 dbSNP
rs1400634270 468 dbSNP
rs1298149495 473 dbSNP
rs1339001635 492 dbSNP
rs577266294 498 dbSNP
rs1046486542 499 dbSNP
rs1243681521 511 dbSNP
rs1289085145 515 dbSNP
rs565229775 525 dbSNP
rs1216618051 527 dbSNP
rs1195255250 528 dbSNP
rs1484887201 529 dbSNP
rs1018849050 532 dbSNP
rs200124092 542 dbSNP
rs1232489025 543 dbSNP
rs80310828 544 dbSNP
rs1205534562 545 dbSNP
rs1185718927 548 dbSNP
rs1382357973 550 dbSNP
rs1439590196 551 dbSNP
rs1055288006 552 dbSNP
rs10715276 554 dbSNP
rs1358685380 554 dbSNP
rs1378934870 554 dbSNP
rs398017951 554 dbSNP
rs986078580 554 dbSNP
rs1394610848 559 dbSNP
rs867241690 564 dbSNP
rs936974814 565 dbSNP
rs1240406619 569 dbSNP
rs1284769567 570 dbSNP
rs7123350 575 dbSNP
rs1212211376 590 dbSNP
rs1183219277 591 dbSNP
rs978456370 596 dbSNP
rs967414290 599 dbSNP
rs912997866 615 dbSNP
rs995326215 619 dbSNP
rs1178227411 621 dbSNP
rs1373090600 630 dbSNP
rs897946573 644 dbSNP
rs1442501682 649 dbSNP
rs954444467 651 dbSNP
rs1014862151 652 dbSNP
rs1310536220 657 dbSNP
rs1014231504 660 dbSNP
rs1433623863 666 dbSNP
rs1395591023 671 dbSNP
rs1464872586 676 dbSNP
rs1175483197 677 dbSNP
rs1401480329 682 dbSNP
rs895835777 683 dbSNP
rs1056418779 684 dbSNP
rs1028815893 686 dbSNP
rs1370563444 691 dbSNP
rs1220411140 696 dbSNP
rs1407012372 700 dbSNP
rs34851255 700 dbSNP
rs1311475085 706 dbSNP
rs1221597776 708 dbSNP
rs1259825380 715 dbSNP
rs996409077 718 dbSNP
rs1198278584 739 dbSNP
rs963328102 739 dbSNP
rs1471284613 757 dbSNP
rs573365072 765 dbSNP
rs1255761049 768 dbSNP
rs76435292 775 dbSNP
rs1479782456 787 dbSNP
rs1173415705 788 dbSNP
rs536719909 793 dbSNP
rs946446925 794 dbSNP
rs1327799256 799 dbSNP
rs1283035053 800 dbSNP
rs929532950 802 dbSNP
rs1214302542 806 dbSNP
rs1352339025 812 dbSNP
rs1024960502 813 dbSNP
rs913677079 818 dbSNP
rs769384028 822 dbSNP
rs1013704534 827 dbSNP
rs987908058 835 dbSNP
rs541686451 840 dbSNP
rs1225899213 851 dbSNP
rs147719122 852 dbSNP
rs557343012 854 dbSNP
rs1279963779 856 dbSNP
rs1318375312 859 dbSNP
rs537437350 869 dbSNP
rs911567292 876 dbSNP
rs1323796578 885 dbSNP
rs1222586167 888 dbSNP
rs936798418 889 dbSNP
rs1489873032 890 dbSNP
rs986413304 908 dbSNP
rs904116070 909 dbSNP
rs1264472994 911 dbSNP
rs1477699862 914 dbSNP
rs953360244 920 dbSNP
rs920412925 927 dbSNP
rs1375556420 928 dbSNP
rs1043004883 935 dbSNP
rs1164995049 943 dbSNP
rs1451566344 952 dbSNP
rs1364435469 954 dbSNP
rs1402511257 956 dbSNP
rs973287766 957 dbSNP
rs571707296 967 dbSNP
rs945734883 981 dbSNP
rs484670 991 dbSNP
rs1014937037 997 dbSNP
rs868232864 1003 dbSNP
rs1159563146 1012 dbSNP
rs377292735 1022 dbSNP
rs780747586 1023 dbSNP
rs1289360493 1024 dbSNP
rs1357406951 1026 dbSNP
rs933109815 1031 dbSNP
rs1287383366 1033 dbSNP
rs1488282592 1035 dbSNP
rs1191655519 1051 dbSNP
rs921646780 1053 dbSNP
rs4937035 1054 dbSNP
rs1182118792 1055 dbSNP
rs1384149586 1060 dbSNP
rs963512754 1061 dbSNP
rs1159999006 1067 dbSNP
rs565839376 1068 dbSNP
rs866958180 1071 dbSNP
rs983796216 1079 dbSNP
rs950599417 1080 dbSNP
rs1342063352 1084 dbSNP
rs1025016111 1089 dbSNP
rs1002187920 1092 dbSNP
rs895236746 1093 dbSNP
rs904803195 1100 dbSNP
rs1034146980 1105 dbSNP
rs1001056678 1113 dbSNP
rs903998137 1114 dbSNP
rs1259716878 1116 dbSNP
rs1281301239 1117 dbSNP
rs1043599920 1128 dbSNP
rs1042543905 1132 dbSNP
rs1010387350 1135 dbSNP
rs891982241 1141 dbSNP
rs1052149621 1146 dbSNP
rs1442471974 1150 dbSNP
rs1180093372 1158 dbSNP
rs944441843 1161 dbSNP
rs1469136323 1163 dbSNP
rs879711980 1167 dbSNP
rs370335780 1173 dbSNP
rs1414835429 1179 dbSNP
rs931876904 1189 dbSNP
rs891374860 1193 dbSNP
rs1333201314 1194 dbSNP
rs182820065 1196 dbSNP
rs1332268912 1200 dbSNP
rs973745201 1200 dbSNP
rs1232325870 1204 dbSNP
rs932952622 1204 dbSNP
rs375709715 1211 dbSNP
rs921713017 1216 dbSNP
rs974875139 1216 dbSNP
rs1261709023 1221 dbSNP
rs555544132 1238 dbSNP
rs1238362725 1239 dbSNP
rs907718262 1240 dbSNP
rs569409352 1242 dbSNP
rs1380097155 1250 dbSNP
rs941770388 1254 dbSNP
rs992872595 1257 dbSNP
rs1175578194 1263 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions hESCs (WA-09)
Disease 399967.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in SRR359787. RNA binding protein: AGO2. Condition:4-thiouridine ...

- Lipchina I; Elkabetz Y; Hafner M; Sheridan et al., 2011, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' gaccucucucucucCGAGUCa 5'
                        |||||| 
Target 5' --------------GCUCAGa 3'
 		1 - 7
Article - Lipchina I; Elkabetz Y; Hafner M; Sheridan et al.
- Genes & development, 2011
MicroRNAs are important regulators in many cellular processes, including stem cell self-renewal. Recent studies demonstrated their function as pluripotency factors with the capacity for somatic cell reprogramming. However, their role in human embryonic stem (ES) cells (hESCs) remains poorly understood, partially due to the lack of genome-wide strategies to identify their targets. Here, we performed comprehensive microRNA profiling in hESCs and in purified neural and mesenchymal derivatives. Using a combination of AGO cross-linking and microRNA perturbation experiments, together with computational prediction, we identified the targets of the miR-302/367 cluster, the most abundant microRNAs in hESCs. Functional studies identified novel roles of miR-302/367 in maintaining pluripotency and regulating hESC differentiation. We show that in addition to its role in TGF-beta signaling, miR-302/367 promotes bone morphogenetic protein (BMP) signaling by targeting BMP inhibitors TOB2, DAZAP2, and SLAIN1. This study broadens our understanding of microRNA function in hESCs and is a valuable resource for future studies in this area.
LinkOut: [PMID: 22012620]
CLIP-seq Support 1 for dataset SRR359787
Method / RBP PAR-CLIP / AGO2
Cell line / Condition hESCs (WA-09) / 4-thiouridine, RNase T1
Location of target site ENST00000358524.3 | 3UTR | GCUCAGACUUGGUCAUUUA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22012620 / SRX103431
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
77 hsa-miR-6751-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT130738 GATAD2B GATA zinc finger domain containing 2B 2 4
MIRT134924 CCND2 cyclin D2 2 2
MIRT273034 ZBTB18 zinc finger and BTB domain containing 18 2 2
MIRT276645 KPNA3 karyopherin subunit alpha 3 2 6
MIRT446531 OAS2 2'-5'-oligoadenylate synthetase 2 2 2
MIRT456268 TDRKH tudor and KH domain containing 2 12
MIRT494454 BTG2 BTG anti-proliferation factor 2 2 2
MIRT494965 USP46 ubiquitin specific peptidase 46 2 2
MIRT496689 KREMEN1 kringle containing transmembrane protein 1 2 2
MIRT496697 RGS11 regulator of G protein signaling 11 2 2
MIRT504376 IRF4 interferon regulatory factor 4 2 6
MIRT510980 PFN2 profilin 2 2 6
MIRT512548 MFN2 mitofusin 2 2 6
MIRT513639 TP53INP2 tumor protein p53 inducible nuclear protein 2 2 2
MIRT514016 CAMSAP1 calmodulin regulated spectrin associated protein 1 2 4
MIRT514074 MTRNR2L6 MT-RNR2-like 6 2 2
MIRT515300 C15orf38-AP3S2 C15orf38-AP3S2 readthrough 2 4
MIRT517285 AP3S2 adaptor related protein complex 3 sigma 2 subunit 2 4
MIRT519075 KCNK6 potassium two pore domain channel subfamily K member 6 2 2
MIRT520779 TCF23 transcription factor 23 2 2
MIRT522485 MFSD9 major facilitator superfamily domain containing 9 2 2
MIRT528856 PKP1 plakophilin 1 2 2
MIRT529081 PATE2 prostate and testis expressed 2 2 2
MIRT531209 PLA2G4D phospholipase A2 group IVD 2 2
MIRT533988 TAB3 TGF-beta activated kinase 1 and MAP3K7 binding protein 3 2 2
MIRT537024 GRIN2B glutamate ionotropic receptor NMDA type subunit 2B 2 2
MIRT537498 FAM168B family with sequence similarity 168 member B 2 2
MIRT553125 UBE2Z ubiquitin conjugating enzyme E2 Z 2 2
MIRT555591 PIP5K1C phosphatidylinositol-4-phosphate 5-kinase type 1 gamma 2 2
MIRT556370 LUZP1 leucine zipper protein 1 2 2
MIRT569745 C2orf71 chromosome 2 open reading frame 71 2 2
MIRT570149 DNAJC10 DnaJ heat shock protein family (Hsp40) member C10 2 2
MIRT571243 FADS6 fatty acid desaturase 6 2 2
MIRT573065 TRIB1 tribbles pseudokinase 1 2 2
MIRT575533 Map4 microtubule-associated protein 4 2 2
MIRT575777 Tnfrsf10b tumor necrosis factor receptor superfamily, member 10b 2 2
MIRT616558 ZNF512B zinc finger protein 512B 2 2
MIRT624851 ABI2 abl interactor 2 2 2
MIRT630078 GRWD1 glutamate rich WD repeat containing 1 2 2
MIRT631479 KLHL21 kelch like family member 21 2 2
MIRT632173 CCL22 C-C motif chemokine ligand 22 2 2
MIRT638397 QSOX2 quiescin sulfhydryl oxidase 2 2 4
MIRT641192 ISG20L2 interferon stimulated exonuclease gene 20 like 2 2 2
MIRT642562 TEX9 testis expressed 9 2 2
MIRT642935 KRTAP5-9 keratin associated protein 5-9 2 2
MIRT649703 ZNF175 zinc finger protein 175 2 2
MIRT650437 CPXM2 carboxypeptidase X, M14 family member 2 2 2
MIRT652113 TRUB2 TruB pseudouridine synthase family member 2 2 2
MIRT652273 TOMM20 translocase of outer mitochondrial membrane 20 2 2
MIRT655215 PFKM phosphofructokinase, muscle 2 2
MIRT682778 ZNF852 zinc finger protein 852 2 2
MIRT683001 MUC20 mucin 20, cell surface associated 2 2
MIRT684320 GTF3C4 general transcription factor IIIC subunit 4 2 2
MIRT689435 CYB561 cytochrome b561 2 2
MIRT693847 ZNF107 zinc finger protein 107 2 2
MIRT696715 TAX1BP3 Tax1 binding protein 3 2 2
MIRT698597 TEX261 testis expressed 261 2 2
MIRT699973 RREB1 ras responsive element binding protein 1 2 2
MIRT703310 GFPT1 glutamine--fructose-6-phosphate transaminase 1 2 2
MIRT706796 RAI1 retinoic acid induced 1 2 2
MIRT709004 CD109 CD109 molecule 2 2
MIRT709181 TBC1D10B TBC1 domain family member 10B 2 2
MIRT709835 PAQR7 progestin and adipoQ receptor family member 7 2 2
MIRT711627 CORO1C coronin 1C 2 2
MIRT712634 RNF103-CHMP3 RNF103-CHMP3 readthrough 2 2
MIRT713694 CYB5R4 cytochrome b5 reductase 4 2 2
MIRT713752 SLC9A8 solute carrier family 9 member A8 2 2
MIRT714908 CHMP3 charged multivesicular body protein 3 2 2
MIRT716371 CBLL1 Cbl proto-oncogene like 1 2 2
MIRT718303 XPOT exportin for tRNA 2 2
MIRT718713 ANKRD18A ankyrin repeat domain 18A 2 2
MIRT718740 ATP9A ATPase phospholipid transporting 9A (putative) 2 2
MIRT719441 NPTX2 neuronal pentraxin 2 2 2
MIRT720896 OTUD4 OTU deubiquitinase 4 2 2
MIRT722448 RXFP4 relaxin/insulin like family peptide receptor 4 2 2
MIRT723882 VKORC1 vitamin K epoxide reductase complex subunit 1 2 2
MIRT724586 SYNJ2BP synaptojanin 2 binding protein 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-6751 Cisplatin 5460033 NSC119875 approved sensitive Low Ovarian Cancer cell line (A2780)
hsa-mir-6751 Triptolide 107985 NSC163062 sensitive Low Ovarian Cancer cell line (A2780)

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