miRTarBase - #MIRT529477


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pre-miRNA Information
pre-miRNA hsa-mir-548al   
Genomic Coordinates chr11: 74399237 - 74399333
Description Homo sapiens miR-548al stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-548al
Sequence 65| AACGGCAAUGACUUUUGUACCA |86
Evidence Experimental
Experiments Illumina
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 1 11 + 74399301 29233923 MiREDiBase
A-to-I 2 11 + 74399302 29233923 MiREDiBase
A-to-I 11 11 + 74399311 29233923 MiREDiBase
A-to-I 22 11 + 74399322 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1006612080 4 dbSNP
rs1228098884 7 dbSNP
rs515924 8 dbSNP
rs145394973 13 dbSNP
rs1339767076 14 dbSNP
rs1409875902 16 dbSNP
Putative Targets

Gene Information
Gene Symbol THUMPD3   
Synonyms -
Description THUMP domain containing 3
Transcript NM_001114092   
Other Transcripts NM_015453   
Expression
Putative miRNA Targets on THUMPD3
3'UTR of THUMPD3
(miRNA target sites are highlighted)		 
>THUMPD3|NM_001114092|3'UTR
   1 AGATGACTAATAGTACTTGTACTTCCCACCACTGGAAATGTTAGCATAAAAGAACTTGGAGAGGAAAAAAGTATTAACAA
  81 AACTGCAGTCTGCACTCTTTAAACCTGTTTAAGGCTCTTCATCCTGGTTAGCAAAAGGTGTGAATGTAATGTGATGGAAT
 161 TTAAAAGTTTTATGAGACCAGGCACAGTGGCTCACGACTGTAATTCCAGCAGTTTAGGAAGCCGAAGTGTGCAGATCACC
 241 TGAGGTCCGGAGACCAGCCTGGCCAACATGGTGAAACCCTGTCTCTACTAGAAATACAAAAATTAGCCAGGTGTGGTGGC
 321 GGGCGCCTGTAATCCCAACTACTCAGGAGGCTGAGGCTAGAGAATCACTTGAACCCAGCAGGCGGAGGTTGCGGTGAGTC
 401 GAGATCACGCCATTGCACTCCAGCCTGTGCGACAAGAGCGAAACTCTGTCTCAAAAAGATTTTATAAGAAAGCAGAGCTT
 481 TTCCTTGAAGCTCTTTTGAAGTGGTAGCTTAATTAGTATTTTGTTGAAAATACTTTAAAGATGCCTAGTGAAAAGCCTAC
 561 TAAAGTGCTGTGAGATTGGGGTTTAGAACATTTTATTTTCAGGCTTTATGGCCTATTTTCCATTGTGTCAAGTGCAAAAC
 641 TACCCTGGCCCAAAGGAAGGGCAGAGAACATAATTACATCTTAGGCCACATTTCATTCTTTGCAGCTTTGCTAATCCAGT
 721 TGCTCAAGTTCTTTACCTCAACCTGAAGGAATGAAGCATTATTACATTTTGTGAATGGTGTTCAGCCTATAAGACGAAGT
 801 CTCACAAGACCTATAGGAAAGTTTACCATCTGCCTTAAATATTAAAATATCCATCTGTTATTCACATTAATACACAGAAT
 881 GAAAATAGAGGTCTAGGAATTATCAAAGGTACTGCAAAAATACTGTATAGAACTTATTTGTAAATAGCACATACATTGAT
 961 AGATGGGGTGTGGGACCAACAAACCAAATTAAAAGAAATTGTTTTTCTTTCAGTACACTAAGGTGTGTGTTTTCAAAACC
1041 AAACACAAACCTGTCAAGAGTATTTGTTGGCTAGTTTCTTAAAAGGCCAAGAGAAAAAAAATGATATATCTTTGGAAAAC
1121 TTTTAATTTGGGAGTTATGTGAGTTGTTACTTTCTCCTGGATCACGATTCACATTTAATTGCTTTTCCAGTTGCAACAAG
1201 TCCTTCTTGAGAGTTTTGTGGAAAATGGTGCTTCCCTGGAACAAAGAGTAGTTGAGGTTTTTTTGTGGAACTCATCATAG
1281 TATTGTTTATTTTGGAGCCTCTGGCTGCAATCAGTATAGATTTTCAGTATCCTATTAGTATTATAATAGTACTCCTCTTA
1361 ATACTTTCTGATGTCTCCATTGAGAATAAAAGGACACAATACTTTTGAAAGAAGAGTTCACATTAGCAGCACAGCCAGCA
1441 ATCCTCATCTGGTTTCTCTGATCTCCTACCCCACACTTCATAATGAATGGGAAATAAGATGTTTATGAAGGTTTTATATC
1521 CTAGACTGGCCTTTTTACCACTATCAGAATTCACAGCTGCTTTGTTTATGGGCCGAACACAAAACTTTTCACCTGATGGG
1601 AGAAACCATTTAAACCTCAAATTAAGCAACCCACAGAACCAGGAAGTTCAAGGACCATGTCTGTTTTCACCACGATGTCT
1681 TTCCCCACCCCCCCACCCCCCACTCCACCCCCCACTAAGGGCAGGGTATTGTATCTGCCAGACTGGGTATTTGTTGAACA
1761 AGCGAGTATTTTCGCCTATTAGCTTAGTTTTTAAGGAAATCATTTTTTACTTGATTCATCATAGCTTTAATTCTATTACA
1841 TACTACAATAAAAATTTGACAAGACTGATACAAATATGTAGTGGGCAATAGTTTGCCGTCTTCTTCCCTAGTATGGTGTT
1921 TTTCAATCTGGTGACTAGAATAGGCAGTGGGCTATAAGCAGGATTCATAAGGCCTGGAGCTGAGTTATATGTGACACTGC
2001 CACCTATTCATTGTGTGACCTTGGTTTTAACCTTCAAAGTGGGTCTCCTGGACTAAAAGAATGTGAAAAGATGGGGAAAT
2081 AAATCTGTAATCTGAACATGGAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' acCAUGUUUUCAGUAACGGCAa 5'
            | :||| |||  ||||||| 
Target 5' gtGGGCAATAGT--TTGCCGTc 3'
 1881 - 1900 160.00 -16.10
2 
miRNA  3' accAUGUUUUCAGUAACGGCAa 5'
             ||| ||||    |||:|| 
Target 5' gccTACTAAAG----TGCTGTg 3'
 555 - 572 116.00 -6.80
3 
miRNA  3' acCAUGUUUUCAGUAACGGCaa 5'
            || |||:|||  |||::|  
Target 5' ctGT-CAAGAGTATTTGTTGgc 3'
 1051 - 1071 115.00 -10.60
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30122061 10 COSMIC
COSN30113962 38 COSMIC
COSN30156206 53 COSMIC
COSN26440805 80 COSMIC
COSN28866835 80 COSMIC
COSN30511840 100 COSMIC
COSN31506960 118 COSMIC
COSN31545152 197 COSMIC
COSN25520021 754 COSMIC
COSN9004695 866 COSMIC
COSN22372746 1332 COSMIC
COSN6784456 1808 COSMIC
COSN6784457 1818 COSMIC
rs2251361 1899 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs927404724 4 dbSNP
rs941932651 6 dbSNP
rs761877456 8 dbSNP
rs1456194716 10 dbSNP
rs200282991 11 dbSNP
rs374689491 12 dbSNP
rs1406674171 16 dbSNP
rs773439136 18 dbSNP
rs763062474 19 dbSNP
rs766366276 20 dbSNP
rs1436532855 23 dbSNP
rs571834814 24 dbSNP
rs532522615 26 dbSNP
rs752955264 28 dbSNP
rs1266334211 33 dbSNP
rs756623856 35 dbSNP
rs1203561873 37 dbSNP
rs1267640002 40 dbSNP
rs897667967 41 dbSNP
rs778182435 44 dbSNP
rs749788042 45 dbSNP
rs757958263 48 dbSNP
rs1421926862 52 dbSNP
rs779412206 53 dbSNP
rs1057447659 64 dbSNP
rs1167848780 65 dbSNP
rs551032386 69 dbSNP
rs994506637 71 dbSNP
rs1051562939 72 dbSNP
rs890203391 81 dbSNP
rs771845779 90 dbSNP
rs1017263946 92 dbSNP
rs1475177629 93 dbSNP
rs1435867110 95 dbSNP
rs1271948798 98 dbSNP
rs757258904 98 dbSNP
rs1346986608 101 dbSNP
rs776396095 106 dbSNP
rs1232897773 108 dbSNP
rs1017974907 117 dbSNP
rs1310997724 118 dbSNP
rs893453684 123 dbSNP
rs1353138116 124 dbSNP
rs147375457 131 dbSNP
rs1011170534 135 dbSNP
rs1021590915 143 dbSNP
rs1404945626 145 dbSNP
rs199760866 148 dbSNP
rs997846072 149 dbSNP
rs966906538 152 dbSNP
rs982684472 155 dbSNP
rs1468751836 158 dbSNP
rs954959695 163 dbSNP
rs1035100908 164 dbSNP
rs1343095714 165 dbSNP
rs536641743 167 dbSNP
rs1221742013 171 dbSNP
rs1287468962 171 dbSNP
rs990803570 174 dbSNP
rs909902326 180 dbSNP
rs139491942 186 dbSNP
rs1449187239 194 dbSNP
rs1271408510 196 dbSNP
rs567228403 197 dbSNP
rs1372629161 198 dbSNP
rs1231427007 199 dbSNP
rs1302629572 201 dbSNP
rs145005055 206 dbSNP
rs927383740 210 dbSNP
rs1407502219 216 dbSNP
rs552769127 219 dbSNP
rs937454074 220 dbSNP
rs1281807102 224 dbSNP
rs72624413 225 dbSNP
rs771001835 227 dbSNP
rs917257950 229 dbSNP
rs1264746992 235 dbSNP
rs1212999430 238 dbSNP
rs929857927 240 dbSNP
rs1290138120 241 dbSNP
rs1052021354 245 dbSNP
rs1229607041 248 dbSNP
rs890234415 249 dbSNP
rs888402304 250 dbSNP
rs1341647179 257 dbSNP
rs1290760129 262 dbSNP
rs1428706781 269 dbSNP
rs1344899150 272 dbSNP
rs1255107856 274 dbSNP
rs1467234298 281 dbSNP
rs796225186 282 dbSNP
rs751788772 286 dbSNP
rs549333195 288 dbSNP
rs762019130 289 dbSNP
rs776779066 290 dbSNP
rs1184321496 292 dbSNP
rs1485259955 294 dbSNP
rs1246719718 296 dbSNP
rs1223343345 304 dbSNP
rs1157205142 305 dbSNP
rs1233031007 307 dbSNP
rs567828446 307 dbSNP
rs893484521 310 dbSNP
rs147554544 312 dbSNP
rs1021246284 321 dbSNP
rs902755446 322 dbSNP
rs1392519291 323 dbSNP
rs1325036630 324 dbSNP
rs148693443 325 dbSNP
rs562180811 326 dbSNP
rs529638228 327 dbSNP
rs142195019 328 dbSNP
rs1425295132 333 dbSNP
rs1192397128 337 dbSNP
rs1452237728 340 dbSNP
rs1251973925 343 dbSNP
rs1016937716 345 dbSNP
rs1458498590 354 dbSNP
rs1253388385 359 dbSNP
rs1203066236 360 dbSNP
rs150735141 363 dbSNP
rs1228650310 369 dbSNP
rs1302122551 372 dbSNP
rs1236563396 381 dbSNP
rs560826051 382 dbSNP
rs1302950237 383 dbSNP
rs775851584 384 dbSNP
rs573592601 385 dbSNP
rs1296197170 391 dbSNP
rs764532101 392 dbSNP
rs540902100 393 dbSNP
rs565507891 394 dbSNP
rs1452028635 395 dbSNP
rs1440068320 397 dbSNP
rs943149711 398 dbSNP
rs554747780 401 dbSNP
rs958796689 403 dbSNP
rs914990880 407 dbSNP
rs1473360357 409 dbSNP
rs1167495329 410 dbSNP
rs532723822 414 dbSNP
rs1257088309 415 dbSNP
rs756654823 418 dbSNP
rs1345830523 420 dbSNP
rs917224828 423 dbSNP
rs929974106 430 dbSNP
rs1042433174 431 dbSNP
rs1304660382 432 dbSNP
rs1390588908 434 dbSNP
rs902787376 434 dbSNP
rs1379891168 435 dbSNP
rs1004220485 437 dbSNP
rs982768580 439 dbSNP
rs550836430 440 dbSNP
rs562999351 441 dbSNP
rs187182329 442 dbSNP
rs1361686162 444 dbSNP
rs1012368860 448 dbSNP
rs1418861821 453 dbSNP
rs1258582190 455 dbSNP
rs1190719639 460 dbSNP
rs1017010763 461 dbSNP
rs757812699 470 dbSNP
rs1294848165 486 dbSNP
rs191892733 490 dbSNP
rs994205145 494 dbSNP
rs1353180407 498 dbSNP
rs1259179462 506 dbSNP
rs1238517631 510 dbSNP
rs1322118415 515 dbSNP
rs1039515880 520 dbSNP
rs1412891551 528 dbSNP
rs1353812939 529 dbSNP
rs1232831525 530 dbSNP
rs1354709396 531 dbSNP
rs566497416 532 dbSNP
rs1383403780 534 dbSNP
rs1382419359 535 dbSNP
rs1157643166 541 dbSNP
rs77638650 549 dbSNP
rs1026085584 557 dbSNP
rs1341636863 559 dbSNP
rs1167507894 560 dbSNP
rs955373835 561 dbSNP
rs1474539210 563 dbSNP
rs182911041 565 dbSNP
rs1272959202 569 dbSNP
rs374632265 570 dbSNP
rs1190525248 571 dbSNP
rs1204798396 573 dbSNP
rs1488907350 574 dbSNP
rs1255762948 585 dbSNP
rs1475082109 601 dbSNP
rs1231205586 614 dbSNP
rs1334143619 619 dbSNP
rs892260986 624 dbSNP
rs1229438440 634 dbSNP
rs964578801 639 dbSNP
rs753399774 648 dbSNP
rs1324189386 650 dbSNP
rs1009218380 652 dbSNP
rs1387030321 657 dbSNP
rs1396190559 658 dbSNP
rs1328408704 659 dbSNP
rs974565344 661 dbSNP
rs377234212 665 dbSNP
rs1394118136 667 dbSNP
rs1169011269 668 dbSNP
rs915025343 669 dbSNP
rs1371438618 670 dbSNP
rs946440173 678 dbSNP
rs1192522962 682 dbSNP
rs140287082 691 dbSNP
rs923614059 696 dbSNP
rs1034485039 698 dbSNP
rs754238317 699 dbSNP
rs1467875042 703 dbSNP
rs150228946 715 dbSNP
rs538820925 719 dbSNP
rs895396429 722 dbSNP
rs1012401262 724 dbSNP
rs1337328159 724 dbSNP
rs1014461733 728 dbSNP
rs188914108 742 dbSNP
rs1413932397 746 dbSNP
rs898642434 758 dbSNP
rs994673473 759 dbSNP
rs193122029 762 dbSNP
rs1370746048 764 dbSNP
rs1439631366 764 dbSNP
rs1025694425 765 dbSNP
rs1412170678 766 dbSNP
rs1394942434 771 dbSNP
rs758234245 779 dbSNP
rs1435414945 785 dbSNP
rs754521122 790 dbSNP
rs1192004289 793 dbSNP
rs982716503 794 dbSNP
rs777580484 796 dbSNP
rs1018906261 797 dbSNP
rs1269607159 805 dbSNP
rs975742368 806 dbSNP
rs1349435518 808 dbSNP
rs921224055 814 dbSNP
rs964609469 815 dbSNP
rs575306849 817 dbSNP
rs1213722230 831 dbSNP
rs974596380 832 dbSNP
rs369762802 836 dbSNP
rs1278796459 852 dbSNP
rs1485577669 853 dbSNP
rs1217764751 854 dbSNP
rs1280558639 856 dbSNP
rs746719589 863 dbSNP
rs967876890 864 dbSNP
rs1444799401 868 dbSNP
rs1262030945 872 dbSNP
rs1334584192 874 dbSNP
rs1328780705 876 dbSNP
rs1448323048 876 dbSNP
rs1050969184 894 dbSNP
rs978250938 897 dbSNP
rs1190417776 898 dbSNP
rs1408962725 900 dbSNP
rs1371928766 912 dbSNP
rs1160149974 920 dbSNP
rs535931969 921 dbSNP
rs11547585 924 dbSNP
rs1188596875 934 dbSNP
rs991775508 938 dbSNP
rs1486588407 939 dbSNP
rs916856039 945 dbSNP
rs1254828393 946 dbSNP
rs1209500171 948 dbSNP
rs1393175254 951 dbSNP
rs1285912081 955 dbSNP
rs1433913938 956 dbSNP
rs1289178475 961 dbSNP
rs185803021 963 dbSNP
rs945121409 969 dbSNP
rs1357886121 970 dbSNP
rs377565531 971 dbSNP
rs1038561406 983 dbSNP
rs1320547478 990 dbSNP
rs1056444806 991 dbSNP
rs778281217 991 dbSNP
rs1317896635 993 dbSNP
rs1331810473 996 dbSNP
rs146810435 997 dbSNP
rs1186687060 999 dbSNP
rs373316869 1002 dbSNP
rs565568668 1012 dbSNP
rs1243288525 1017 dbSNP
rs1347740220 1018 dbSNP
rs761900517 1019 dbSNP
rs1241357527 1023 dbSNP
rs1267942740 1023 dbSNP
rs1337665007 1029 dbSNP
rs1014823339 1030 dbSNP
rs1024439330 1033 dbSNP
rs1291821453 1034 dbSNP
rs1047630903 1038 dbSNP
rs1228169251 1043 dbSNP
rs1362896515 1053 dbSNP
rs891203487 1054 dbSNP
rs1272188270 1056 dbSNP
rs1008261063 1057 dbSNP
rs1486645285 1058 dbSNP
rs540451991 1061 dbSNP
rs1203079866 1063 dbSNP
rs1260599500 1064 dbSNP
rs538437729 1068 dbSNP
rs189111050 1069 dbSNP
rs1462951410 1071 dbSNP
rs1468576377 1079 dbSNP
rs1194930062 1085 dbSNP
rs1251101007 1089 dbSNP
rs562903120 1091 dbSNP
rs1047825 1092 dbSNP
rs1047824 1094 dbSNP
rs1428947443 1094 dbSNP
rs746027553 1105 dbSNP
rs1184435077 1107 dbSNP
rs1022177331 1108 dbSNP
rs769731587 1110 dbSNP
rs1253092415 1111 dbSNP
rs1215097172 1115 dbSNP
rs962676936 1117 dbSNP
rs376812702 1120 dbSNP
rs1221258738 1125 dbSNP
rs71314346 1127 dbSNP
rs552445625 1132 dbSNP
rs1213041870 1136 dbSNP
rs1364462846 1136 dbSNP
rs1443235933 1139 dbSNP
rs1323915416 1140 dbSNP
rs548253284 1143 dbSNP
rs960427853 1151 dbSNP
rs1443269004 1154 dbSNP
rs955346074 1165 dbSNP
rs560148199 1166 dbSNP
rs191587463 1167 dbSNP
rs546535162 1173 dbSNP
rs370852085 1175 dbSNP
rs1356080058 1180 dbSNP
rs1315565921 1197 dbSNP
rs571521252 1198 dbSNP
rs1167801819 1200 dbSNP
rs1238755517 1203 dbSNP
rs1259827810 1206 dbSNP
rs947691055 1207 dbSNP
rs1194938626 1208 dbSNP
rs750488957 1209 dbSNP
rs1335035162 1213 dbSNP
rs768958533 1215 dbSNP
rs1481131084 1220 dbSNP
rs913757188 1227 dbSNP
rs974734024 1228 dbSNP
rs1341704892 1229 dbSNP
rs1270654227 1235 dbSNP
rs1236544984 1243 dbSNP
rs1345852088 1258 dbSNP
rs1391904395 1258 dbSNP
rs945070799 1258 dbSNP
rs532265392 1267 dbSNP
rs1375533566 1275 dbSNP
rs550765993 1277 dbSNP
rs920188098 1278 dbSNP
rs1409040984 1283 dbSNP
rs1375647416 1285 dbSNP
rs568930400 1290 dbSNP
rs1175161712 1296 dbSNP
rs1177766443 1300 dbSNP
rs1432272539 1302 dbSNP
rs1376589160 1304 dbSNP
rs1175895278 1308 dbSNP
rs1252550880 1309 dbSNP
rs1420200509 1309 dbSNP
rs1417121581 1310 dbSNP
rs774859370 1311 dbSNP
rs930170805 1314 dbSNP
rs1047214516 1315 dbSNP
rs1213315111 1317 dbSNP
rs1484697028 1321 dbSNP
rs891239933 1333 dbSNP
rs777747847 1337 dbSNP
rs1463158349 1339 dbSNP
rs536382741 1345 dbSNP
rs944121365 1349 dbSNP
rs937653898 1356 dbSNP
rs1318636327 1358 dbSNP
rs372820839 1361 dbSNP
rs1054826546 1365 dbSNP
rs1355879520 1366 dbSNP
rs1314269755 1367 dbSNP
rs369245900 1369 dbSNP
rs762024095 1371 dbSNP
rs1371775188 1380 dbSNP
rs1157625094 1381 dbSNP
rs1472438865 1385 dbSNP
rs1391213645 1391 dbSNP
rs1190605093 1396 dbSNP
rs1440901437 1398 dbSNP
rs1022670882 1408 dbSNP
rs1294243887 1412 dbSNP
rs1486909313 1413 dbSNP
rs533768055 1414 dbSNP
rs1208046030 1424 dbSNP
rs578209000 1426 dbSNP
rs1004371012 1428 dbSNP
rs1231287401 1429 dbSNP
rs1339485940 1436 dbSNP
rs1295897841 1437 dbSNP
rs1030853877 1439 dbSNP
rs746828537 1440 dbSNP
rs960501712 1448 dbSNP
rs991879262 1449 dbSNP
rs558543911 1450 dbSNP
rs1319057727 1451 dbSNP
rs1023303648 1460 dbSNP
rs1457177729 1460 dbSNP
rs1270866765 1461 dbSNP
rs1333575916 1470 dbSNP
rs1016971446 1472 dbSNP
rs1204567898 1482 dbSNP
rs1253035970 1486 dbSNP
rs1194198571 1492 dbSNP
rs1479589220 1494 dbSNP
rs1430322946 1495 dbSNP
rs898603920 1498 dbSNP
rs1188080790 1505 dbSNP
rs750887390 1512 dbSNP
rs973757478 1518 dbSNP
rs920200097 1524 dbSNP
rs1211554120 1540 dbSNP
rs1257883419 1541 dbSNP
rs1355414366 1543 dbSNP
rs951643369 1544 dbSNP
rs1186153006 1546 dbSNP
rs1229167937 1547 dbSNP
rs1296214465 1561 dbSNP
rs1324100580 1561 dbSNP
rs1441073866 1565 dbSNP
rs1417391734 1572 dbSNP
rs983414375 1573 dbSNP
rs1328561346 1575 dbSNP
rs759123038 1575 dbSNP
rs912747112 1576 dbSNP
rs1390484745 1579 dbSNP
rs377399875 1582 dbSNP
rs944152657 1590 dbSNP
rs1020768103 1597 dbSNP
rs966527364 1598 dbSNP
rs770585155 1599 dbSNP
rs1461872948 1603 dbSNP
rs370733037 1604 dbSNP
rs1314013966 1606 dbSNP
rs193208916 1607 dbSNP
rs1413296186 1623 dbSNP
rs1250971556 1624 dbSNP
rs1197402343 1625 dbSNP
rs1339613355 1635 dbSNP
rs921344262 1637 dbSNP
rs867797590 1641 dbSNP
rs1377937900 1643 dbSNP
rs1043045803 1644 dbSNP
rs1306200556 1649 dbSNP
rs1434952970 1650 dbSNP
rs1331104154 1662 dbSNP
rs1329948291 1668 dbSNP
rs1393549887 1668 dbSNP
rs1297023436 1671 dbSNP
rs879558551 1671 dbSNP
rs372720327 1674 dbSNP
rs71626921 1674 dbSNP
rs999463633 1675 dbSNP
rs1052272029 1677 dbSNP
rs896327567 1678 dbSNP
rs71626922 1679 dbSNP
rs1013371829 1681 dbSNP
rs1038532639 1683 dbSNP
rs1241791579 1683 dbSNP
rs1280940927 1684 dbSNP
rs1211175615 1685 dbSNP
rs1250554066 1685 dbSNP
rs1486329925 1686 dbSNP
rs1486558729 1687 dbSNP
rs1280687141 1688 dbSNP
rs1431430286 1688 dbSNP
rs2923022 1688 dbSNP
rs1241570856 1689 dbSNP
rs1349039444 1689 dbSNP
rs1208427366 1691 dbSNP
rs370948889 1692 dbSNP
rs1055587844 1693 dbSNP
rs1415630628 1693 dbSNP
rs1332254857 1694 dbSNP
rs1183834265 1695 dbSNP
rs1188376571 1695 dbSNP
rs1028705327 1696 dbSNP
rs986783281 1696 dbSNP
rs1410960798 1698 dbSNP
rs1417538899 1698 dbSNP
rs1188475539 1701 dbSNP
rs1475976755 1702 dbSNP
rs1427977553 1703 dbSNP
rs1174869859 1705 dbSNP
rs1447107191 1708 dbSNP
rs1397390944 1709 dbSNP
rs891138103 1711 dbSNP
rs1008269147 1713 dbSNP
rs1288105189 1714 dbSNP
rs1433280600 1714 dbSNP
rs1312599279 1715 dbSNP
rs1381580665 1715 dbSNP
rs1358231748 1720 dbSNP
rs1020882573 1724 dbSNP
rs1290264737 1725 dbSNP
rs1320131918 1726 dbSNP
rs1359327373 1726 dbSNP
rs184174800 1732 dbSNP
rs1462855081 1734 dbSNP
rs969097707 1738 dbSNP
rs1032192617 1742 dbSNP
rs959341088 1745 dbSNP
rs1349920455 1747 dbSNP
rs375111188 1753 dbSNP
rs553728688 1754 dbSNP
rs1186194931 1762 dbSNP
rs867229602 1764 dbSNP
rs116544611 1765 dbSNP
rs541959166 1768 dbSNP
rs1317753211 1774 dbSNP
rs560457885 1775 dbSNP
rs983102340 1776 dbSNP
rs983062451 1777 dbSNP
rs912778113 1779 dbSNP
rs940291294 1782 dbSNP
rs1038480009 1783 dbSNP
rs560207170 1788 dbSNP
rs768851137 1791 dbSNP
rs1364330945 1799 dbSNP
rs932695600 1801 dbSNP
rs1049830230 1802 dbSNP
rs1347914670 1806 dbSNP
rs891246951 1807 dbSNP
rs527730513 1811 dbSNP
rs1042423998 1814 dbSNP
rs1166145261 1815 dbSNP
rs1448386397 1817 dbSNP
rs1247899874 1820 dbSNP
rs1194821510 1834 dbSNP
rs1489634696 1836 dbSNP
rs1245342518 1838 dbSNP
rs145647826 1840 dbSNP
rs1409262033 1841 dbSNP
rs1000785466 1844 dbSNP
rs1341569357 1844 dbSNP
rs921376321 1857 dbSNP
rs1160902896 1859 dbSNP
rs1442717066 1862 dbSNP
rs959226980 1864 dbSNP
rs564288235 1867 dbSNP
rs1305825296 1870 dbSNP
rs138175642 1872 dbSNP
rs1043507244 1878 dbSNP
rs188700682 1882 dbSNP
rs1423742809 1885 dbSNP
rs1373121462 1886 dbSNP
rs1190947996 1888 dbSNP
rs1481183346 1890 dbSNP
rs879199295 1892 dbSNP
rs2251361 1899 dbSNP
rs781231244 1901 dbSNP
rs529906635 1904 dbSNP
rs974306283 1910 dbSNP
rs1013402501 1912 dbSNP
rs548352395 1913 dbSNP
rs1224086852 1915 dbSNP
rs1328690652 1917 dbSNP
rs745771650 1921 dbSNP
rs1214411306 1929 dbSNP
rs1286002323 1932 dbSNP
rs1044858305 1934 dbSNP
rs912617982 1936 dbSNP
rs1275055084 1937 dbSNP
rs767696922 1938 dbSNP
rs1304057072 1939 dbSNP
rs1375743984 1939 dbSNP
rs1357891686 1953 dbSNP
rs905000710 1953 dbSNP
rs944119812 1955 dbSNP
rs1042370956 1960 dbSNP
rs995280967 1963 dbSNP
rs374863429 1968 dbSNP
rs886777950 1973 dbSNP
rs1004280848 1980 dbSNP
rs533833669 1981 dbSNP
rs1482334043 1982 dbSNP
rs1255284277 1983 dbSNP
rs965604837 1984 dbSNP
rs1175810302 1985 dbSNP
rs1286216872 1985 dbSNP
rs74327255 1992 dbSNP
rs780311760 1993 dbSNP
rs1314472390 1998 dbSNP
rs1456329891 2001 dbSNP
rs1053705275 2006 dbSNP
rs1302710549 2008 dbSNP
rs1165020416 2012 dbSNP
rs1028510975 2028 dbSNP
rs895078825 2032 dbSNP
rs1391539806 2037 dbSNP
rs749312816 2042 dbSNP
rs769011505 2044 dbSNP
rs970427792 2045 dbSNP
rs1189898572 2052 dbSNP
rs1322853037 2055 dbSNP
rs570326439 2057 dbSNP
rs1187247944 2060 dbSNP
rs1255559500 2060 dbSNP
rs1466182164 2065 dbSNP
rs924687403 2068 dbSNP
rs1335263470 2071 dbSNP
rs1266784873 2072 dbSNP
rs1444135969 2073 dbSNP
rs571203047 2077 dbSNP
rs1320813458 2083 dbSNP
rs1350106255 2088 dbSNP
rs374424945 2090 dbSNP
rs1234203385 2096 dbSNP
rs1436703894 2102 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions hESCs (WA-09)
Disease 25917.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in SRR359787. RNA binding protein: AGO2. Condition:4-thiouridine ...

- Lipchina I; Elkabetz Y; Hafner M; Sheridan et al., 2011, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' accauguUUUCAGUAACGGCAa 5'
                 | |||  ||||||| 
Target 5' -------AUAGU--UUGCCGUc 3'
 		1 - 13
Article - Lipchina I; Elkabetz Y; Hafner M; Sheridan et al.
- Genes & development, 2011
MicroRNAs are important regulators in many cellular processes, including stem cell self-renewal. Recent studies demonstrated their function as pluripotency factors with the capacity for somatic cell reprogramming. However, their role in human embryonic stem (ES) cells (hESCs) remains poorly understood, partially due to the lack of genome-wide strategies to identify their targets. Here, we performed comprehensive microRNA profiling in hESCs and in purified neural and mesenchymal derivatives. Using a combination of AGO cross-linking and microRNA perturbation experiments, together with computational prediction, we identified the targets of the miR-302/367 cluster, the most abundant microRNAs in hESCs. Functional studies identified novel roles of miR-302/367 in maintaining pluripotency and regulating hESC differentiation. We show that in addition to its role in TGF-beta signaling, miR-302/367 promotes bone morphogenetic protein (BMP) signaling by targeting BMP inhibitors TOB2, DAZAP2, and SLAIN1. This study broadens our understanding of microRNA function in hESCs and is a valuable resource for future studies in this area.
LinkOut: [PMID: 22012620]
CLIP-seq Support 1 for dataset SRR359787
Method / RBP PAR-CLIP / AGO2
Cell line / Condition hESCs (WA-09) / 4-thiouridine, RNase T1
Location of target site ENST00000345094.3 | 3UTR | AUAGUUUGCCGUCUUCUUCC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22012620 / SRX103431
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
15 hsa-miR-548al Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT100248 MRPS18B mitochondrial ribosomal protein S18B 2 2
MIRT466864 STX6 syntaxin 6 2 2
MIRT472971 MSANTD3 Myb/SANT DNA binding domain containing 3 2 2
MIRT477531 EIF4G2 eukaryotic translation initiation factor 4 gamma 2 2 5
MIRT483200 PIP4K2A phosphatidylinositol-5-phosphate 4-kinase type 2 alpha 2 2
MIRT496727 NKD2 naked cuticle homolog 2 2 2
MIRT504947 ZNRF2 zinc and ring finger 2 2 6
MIRT529248 TRIM4 tripartite motif containing 4 2 2
MIRT529477 THUMPD3 THUMP domain containing 3 2 2
MIRT576335 Rapgefl1 Rap guanine nucleotide exchange factor (GEF)-like 1 2 5
MIRT607473 RAPGEFL1 Rap guanine nucleotide exchange factor like 1 2 7
MIRT629228 FAM186A family with sequence similarity 186 member A 2 2
MIRT651501 WT1 Wilms tumor 1 2 2
MIRT662296 SLC29A4 solute carrier family 29 member 4 2 2
MIRT688897 C1GALT1 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-54 Nicotine approved 89594 Microarray Caenorhabditis elegans 23765240 2013 up-regualted
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-548al Doxorubicin 31703 NSC123127 approved sensitive cell line (W1)
hsa-mir-548al Paclitaxel 36314 NSC125973 approved sensitive cell line (A2780)
hsa-mir-548al Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-miR-548al Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM17)
hsa-miR-548al Tamoxifen+Fulvestrant resistant cell line (LCC9)
hsa-miR-548al Paclitaxel 36314 NSC125973 approved sensitive cell line (A2780)
hsa-miR-548al Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-miR-548al Cisplatin 5460033 NSC119875 approved resistant cell line (MGC-803)
hsa-miR-548al Vemurafenib 42611257 NSC761431 approved resistant cell line (LM16)

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